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Jacques Chollet

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Chemicals & Drugs

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Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Susan A Charman; Sarah Arbe-Barnes; Ian C Bathurst; Reto Brun; Michael Campbell; William N Charman; Francis C K Chiu; Jacques Chollet; J Carl Craft; Darren J Creek; Yuxiang Dong; Hugues Matile; Melanie Maurer; Julia Morizzi; Tien Nguyen; Petros Papastogiannidis; Christian Scheurer; David M Shackleford; Kamaraj Sriraghavan; Lukas Stingelin; Yuanqing Tang; Heinrich Urwyler; Xiaofang Wang; Karen L White; Sergio Wittlin; Lin Zhou; Jonathan L Vennerstrom
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Yuxiang Dong; Kevin J McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L Vennerstrom
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.

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All Publications

2013: Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Journal of medicinal chemistry 2013;56(6):2547-55.
2011: Susan A Charman; Sarah Arbe-Barnes; Ian C Bathurst; Reto Brun; Michael Campbell; William N Charman; Francis C K Chiu; Jacques Chollet; J Carl Craft; Darren J Creek; Yuxiang Dong; Hugues Matile; Melanie Maurer; Julia Morizzi; Tien Nguyen; Petros Papastogiannidis; Christian Scheurer; David M Shackleford; Kamaraj Sriraghavan; Lukas Stingelin; Yuanqing Tang; Heinrich Urwyler; Xiaofang Wang; Karen L White; Sergio Wittlin; Lin Zhou; Jonathan L Vennerstrom
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4400-5.
2010: Yuxiang Dong; Kevin J McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L Vennerstrom
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
Bioorganic & medicinal chemistry letters 2010;20(22):6359-61.
2010: Yuxiang Dong; Jacques Chollet; Mireille Vargas; Nuha R Mansour; Quentin Bickle; Yazen Alnouti; Jiangeng Huang; Jennifer Keiser; Jonathan L Vennerstrom
Praziquantel analogs with activity against juvenile Schistosoma mansoni.
Bioorganic & medicinal chemistry letters 2010;20(8):2481-4.
2010: Yuanqing Tang; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; Julia Morizzi; Lisa M Johnson; Josefina Santo Tomas; Christian Scheurer; Chistopher Snyder; Lin Zhou; Yuxiang Dong; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Jonathan L Vennerstrom
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorganic & medicinal chemistry letters 2010;20(2):563-6.
2010: Yuxiang Dong; Sergio Wittlin; Kamaraj Sriraghavan; Jacques Chollet; Susan A Charman; William N Charman; Christian Scheurer; Heinrich Urwyler; Josefina Santo Tomas; Christopher Snyder; Darren J Creek; Julia Morizzi; Maria Koltun; Hugues Matile; Xiaofang Wang; Maniyan Padmanilayam; Yuanqing Tang; Arnulf Dorn; Reto Brun; Jonathan L Vennerstrom
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Journal of medicinal chemistry 2010;53(1):481-91.
2009: Shu-Hua Xiao; Jacques Chollet; Jürg Utzinger; Jin-Yan Mei; Pei-ying Jiao; Jennifer Keiser; Marcel Tanner
Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice.
Parasitology research 2009;105(3):853-61.
2009: Xiaofang Wang; Darren J Creek; Charles E Schiaffo; Yuxiang Dong; Jacques Chollet; Christian Scheurer; Sergio Wittlin; Susan A Charman; Patrick H Dussault; James K Wood; Jonathan L Vennerstrom
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorganic & medicinal chemistry letters 2009;19(16):4542-5.
2009: Chao-Wei Zhang; Shu-Hua Xiao; Jürg Utzinger; Jacques Chollet; Jennifer Keiser; Marcel Tanner
Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine.
Parasitology research 2009;104(6):1407-16.
2007: Xiaofang Wang; Yuxiang Dong; Sergio Wittlin; Darren J Creek; Jacques Chollet; Susan A Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jonathan L Vennerstrom
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Journal of medicinal chemistry 2007;50(23):5840-7.
2007: Yuxiang Dong; Darren J Creek; Jacques Chollet; Hugues Matile; Susan A Charman; Sergio Wittlin; James K Wood; Jonathan L Vennerstrom
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
Antimicrobial agents and chemotherapy 2007;51(8):3033-5.
2007: Shu-Hua Xiao; Jennifer Keiser; Jacques Chollet; Jürg Utzinger; Yuxiang Dong; Yvette Endriss; Jonathan L Vennerstrom; Marcel Tanner
In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species.
Antimicrobial agents and chemotherapy 2007;51(4):1440-5.
2007: Jennifer Keiser; Xiao Shu-Hua; Jacques Chollet; Marcel Tanner; Jürg Utzinger
Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini.
Antimicrobial agents and chemotherapy 2007;51(3):1096-8.
2007: Yuanqing Tang; Yuxiang Dong; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Saroj Bajpai; Xiaofang Wang; Maniyan Padmanilayam; Jean M Karle; Reto Brun; Jonathan L Vennerstrom
Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.
Bioorganic & medicinal chemistry letters 2007;17(5):1260-5.
2007: Christopher Snyder; Jacques Chollet; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
Experimental parasitology 2007;115(3):296-300.
2006: Shu-Hua Xiao; Marcel Tanner; Binggui G Shen; Jürg Utzinger; Jacques Chollet
Effect of artemether on the tegument of adult Schistosoma haematobium recovered from mice.
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 2006;24(6):425-32.
2006: Maniyan Padmanilayam; Bernard Scorneaux; Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Darren J Creek; William N Charman; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.
Bioorganic & medicinal chemistry letters 2006;16(21):5542-5.
2006: Shu-ua Xiao; Jürg Utzinger; Binggui G Shen; Marcel Tanner; Jacques Chollet
Ultrastructural alterations of adult schistosoma haematobium harbored in mice following artemether administration.
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 2006;24(5):321-8.
2006: Yuxiang Dong; Yuanqing Tang; Jacques Chollet; Hugues Matile; Sergio Wittlin; Susan A Charman; William N Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Bernard Scorneaux; Saroj Bajpai; Scott A Alexander; Xiaofang Wang; Maniyan Padmanilayam; Srinivasa R Cheruku; Reto Brun; Jonathan L Vennerstrom
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Bioorganic & medicinal chemistry 2006;14(18):6368-82.
2006: Jennifer Keiser; Nadia Abou El Ela; Engy El Komy; Naglaa El-Lakkany; Tarek Diab; Jacques Chollet; Jürg Utzinger; Rashida Barakat
Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
The American journal of tropical medicine and hygiene 2006;75(2):287-91.
2006: Xiao Shu-Hua; Jürg Utzinger; Jacques Chollet; Marcel Tanner
Effect of artemether administered alone or in combination with praziquantel to mice infected with Plasmodium berghei or Schistosoma mansoni or both.
International journal for parasitology 2006;36(8):957-64.
2005: Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Journal of medicinal chemistry 2005;48(15):4953-61.
2004: Robert Bergquist; Jürg Utzinger; Jacques Chollet; Xiao Shu-Hua; Niklaus A Weiss; Marcel Tanner
Triggering of high-level resistance against Schistosoma mansoni reinfection by artemether in the mouse model.
The American journal of tropical medicine and hygiene 2004;71(6):774-7.
2004: Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature 2004;430(7002):900-4.
2004: Shu-Hua Xiao; Jian Guo; Jacques Chollet; Jia-tong Wu; Marcel Tanner; Jürg Utzinger
Effect of artemether on Schistosoma mansoni: dose-efficacy relationship, and changes in worm morphology and histopathology.
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 2004;22(3):148-53.
2004: Shu-Hua Xiao; Jun-Min Yao; Jürg Utzinger; Yue Cai; Jacques Chollet; Marcel Tanner
Selection and reversal of Plasmodium berghei resistance in the mouse model following repeated high doses of artemether.
Parasitology research 2004;92(3):215-9.
2003: Shu-Hua Xiao; Yu-Lin Wu; Marcel Tanner; Wen-Min Wu; Jürg Utzinger; Jin-Yan Mei; Bernard Scorneaux; Jacques Chollet; Zili Zhai
Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media.
Parasitology research 2003;89(6):459-66.
2003: Eliézer K N'Goran; Jürg Utzinger; Henri N Gnaka; Ahoua Yapi; Nicaise A N'Guessan; Silué D Kigbafori; Christian Lengeler; Jacques Chollet; Xiao Shuhua; Marcel Tanner
Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.
The American journal of tropical medicine and hygiene 2003;68(1):24-32.
2002: Shu-Hua Xiao; Ji-Qing You; Hui-Fang Gao; Jin-Yan Mei; Pei-ying Jiao; Jacques Chollet; Marcel Tanner; Jürg Utzinger
Schistosoma japonicum: effect of artemether on glutathione S-transferase and superoxide dismutase.
Experimental parasitology 2002;102(1):38-45.
2002: Shuhua Xiao; Binggui Shen; Jürg Utzinger; Jacques Chollet; Marcel Tanner
Ultrastructural alterations in adult Schistosoma mansoni caused by artemether.
Memórias do Instituto Oswaldo Cruz 2002;97(5):717-24.
2002: Jürg Utzinger; Jacques Chollet; Zuwu Tu; Shuhua Xiao; Marcel Tanner
Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(3):318-23.
2002: Shuhua Xiao; Marcel Tanner; Eliézer K N'Goran; Jürg Utzinger; Jacques Chollet; Robert Bergquist; Minggang Chen; Jiang Zheng
Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia.
Acta tropica 2002;82(2):175-81.
2002: Shuhua Xiao; Binggui G Shen; Jürg Utzinger; Jacques Chollet; Marcel Tanner
Transmission electron microscopic observations on ultrastructural damage in juvenile Schistosoma mansoni caused by artemether.
Acta tropica 2002;81(1):53-61.
2001: Shuhua Xiao; Binggui Shen; Jacques Chollet; Jürg Utzinger; Marcel Tanner
Tegumental alterations in juvenile Schistosoma haematobium harboured in hamsters following artemether treatment.
Parasitology international 2001;50(3):175-83.
2001: Yuanqing Yang; Shuhua Xiao; Marcel Tanner; Jürg Utzinger; Jacques Chollet; J Wu; J Guo
Histopathological changes in juvenile Schistosoma haematobium harboured in hamsters treated with artemether.
Acta tropica 2001;79(2):135-41.
2001: Shuhua Xiao; Jacques Chollet; Jürg Utzinger; Hugues Matile; Jinying Mei; Marcel Tanner
Artemether administered together with haemin damages schistosomes in vitro.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(1):67-71.
2000: Shuhua Xiao; Binggui Shen; Jacques Chollet; Jürg Utzinger; Marcel Tanner
Tegumental changes in adult Schistosoma mansoni harbored in mice treated with artemether.
The Journal of parasitology 2000;86(5):1125-32.
2000: Xiao Shuhua; S Binggui; Jacques Chollet; Marcel Tanner
Tegumental changes in adult Schistosoma mansoni harboured in mice treated with praziquantel enantiomers.
Acta tropica 2000;76(2):107-17.
2000: Shuhua Xiao; Jürg Utzinger; Jacques Chollet; Y Endriss; Eliézer K N'Goran; Marcel Tanner
Effect of artemether against Schistosoma haematobium in experimentally infected hamsters.
International journal for parasitology 2000;30(9):1001-6.
2000: Shuhua Xiao; S Binggui; Jacques Chollet; Marcel Tanner
Tegumental changes in 21-day-old Schistosoma mansoni harboured in mice treated with artemether.
Acta tropica 2000;75(3):341-8.
2000: Xiao Shuhua; Jacques Chollet; Niklaus A Weiss; Robert Bergquist; Marcel Tanner
Preventive effect of artemether in experimental animals infected with Schistosoma mansoni.
Parasitology international 2000;49(1):19-24.
2000: J Alzeer; Jacques Chollet; I Heinze-Krauss; Christian Hubschwerlen; Hugues Matile; RG Ridley
Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore.
Journal of medicinal chemistry 2000;43(4):560-8.
1999: Shuhua Xiao; Jacques Chollet; M Booth; Niklaus A Weiss; Marcel Tanner
Therapeutic effect of praziquantel enantiomers in mice infected with Schistosoma mansoni.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93(3):324-5.
1999: Yuxiang Dong; Hugues Matile; Jacques Chollet; R Kaminsky; James K Wood; Jonathan L Vennerstrom
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
Journal of medicinal chemistry 1999;42(8):1477-80.