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Rajiv Chopra

Research Profile

Chemicals & Drugs

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X Ray Crystallography

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Publications

TOP 3
Ping Zhou; Yanfang Li; Yi Fan; Zheng Wang; Rajiv Chopra; Andrea Olland; Yun Hu; Ronald L Magolda; Menelas Pangalos; Peter H Reinhart; M James Turner; Jonathan Bard; Michael S Malamas; Albert J Robichaud
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.
Michael S Malamas; Jim Erdei; Iwan Gunawan; Jim Turner; Yun Hu; Erik Wagner; Kristi Fan; Rajiv Chopra; Andrea Olland; Jonathan Bard; Steve Jacobsen; Ronald L Magolda; Menelas Pangalos; Albert J Robichaud
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
Michael S Malamas; Keith Barnes; Matthew Johnson; Yu Hui; Ping Zhou; Jim Turner; Yun Hu; Erik Wagner; Kristi Fan; Rajiv Chopra; Andrea Olland; Jonathan Bard; Menelas Pangalos; Peter Reinhart; Albert J Robichaud
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.

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All Publications

2010: Ping Zhou; Yanfang Li; Yi Fan; Zheng Wang; Rajiv Chopra; Andrea Olland; Yun Hu; Ronald L Magolda; Menelas Pangalos; Peter H Reinhart; M James Turner; Jonathan Bard; Michael S Malamas; Albert J Robichaud
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(7):2326-9.
2010: Michael S Malamas; Jim Erdei; Iwan Gunawan; Jim Turner; Yun Hu; Erik Wagner; Kristi Fan; Rajiv Chopra; Andrea Olland; Jonathan Bard; Steve Jacobsen; Ronald L Magolda; Menelas Pangalos; Albert J Robichaud
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
Journal of medicinal chemistry 2010;53(3):1146-58.
2010: Michael S Malamas; Keith Barnes; Matthew Johnson; Yu Hui; Ping Zhou; Jim Turner; Yun Hu; Erik Wagner; Kristi Fan; Rajiv Chopra; Andrea Olland; Jonathan Bard; Menelas Pangalos; Peter Reinhart; Albert J Robichaud
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.
Bioorganic & medicinal chemistry 2010;18(2):630-9.
2009: Andrea M Olland; James Strand; Eleonora Presman; Robert Czerwinski; Diane Joseph-McCarthy; Rustem Krykbaev; Gerhard Schlingmann; Rajiv Chopra; Laura Lin; Margaret Fleming; Ron Kriz; Mark Stahl; William Somers; Lori Fitz; Lidia Mosyak
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein science : a publication of the Protein Society 2009;18(3):569-78.
2008: Anita Y M Howe; Huiming Cheng; Stephen Johann; Stanley Mullen; Srinivas K Chunduru; Dorothy C Young; Joel Bard; Rajiv Chopra; Girija Krishnamurthy; Tarek Mansour; John O'Connell
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Antimicrobial agents and chemotherapy 2008;52(9):3327-38.
2008: Ariamala Gopalsamy; Mengxiao Shi; Jennifer M Golas; Erik Vogan; Jaison Jacob; Mark Johnson; Frederick Lee; Ramaswamy Nilakantan; Roseann Petersen; Kristine Svenson; Rajiv Chopra; May S Tam; Yingxia Wen; John W Ellingboe; Kim Arndt; Frank Boschelli
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Journal of medicinal chemistry 2008;51(3):373-5.
2008: Derek C Cole; Joseph R Stock; Rajiv Chopra; Rebecca Cowling; John W Ellingboe; Kristi Y Fan; Boyd L Harrison; Yun Hu; Steve Jacobsen; Lee D Jennings; Guixian Jin; Peter A Lohse; Michael S Malamas; Eric S Manas; William J Moore; Mary-Margaret O'Donnell; Andrea M Olland; Albert J Robichaud; Kristine Svenson; JunJun Wu; Eric Wagner; Jonathan Bard
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorganic & medicinal chemistry letters 2008;18(3):1063-6.
2008: Lee D Jennings; Derek C Cole; Joseph R Stock; Mohani N Sukhdeo; John W Ellingboe; Rebecca Cowling; Guixian Jin; Eric S Manas; Kristi Y Fan; Michael S Malamas; Boyd L Harrison; Steve Jacobsen; Rajiv Chopra; Peter A Lohse; William J Moore; Mary-Margaret O'Donnell; Yun Hu; Albert J Robichaud; M James Turner; Erik Wagner; Jonathan Bard
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Bioorganic & medicinal chemistry letters 2008;18(2):767-71.
2007: William F Fobare; William R Solvibile; Albert J Robichaud; Michael S Malamas; Eric S Manas; Jim Turner; Yun Hu; Erik Wagner; Rajiv Chopra; Rebecca Cowling; Guixian Jin; Jonathan Bard
Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(19):5353-6.
2007: Thomas Nittoli; Kevin Joseph Curran; Shabana Insaf; Martin J DiGrandi; Mark Orlowski; Rajiv Chopra; Atul Agarwal; Anita Y M Howe; Amar Prashad; M Brawner Floyd; Bernard Johnson; Alan Sutherland; Karen L Wheless; Boris Feld; John O'Connell; Tarek S Mansour; Jonathan Bloom
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Journal of medicinal chemistry 2007;50(9):2108-16.
2006: Anita Y M Howe; Huiming Cheng; Ian Thompson; Srinivas K Chunduru; Steve Herrmann; John O'Connell; Atul Agarwal; Rajiv Chopra; Alfred M Del Vecchio
Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.
Antimicrobial agents and chemotherapy 2006;50(12):4103-13.
2006: Derek C Cole; Eric S Manas; Joseph R Stock; Jeffrey S Condon; Lee D Jennings; Ann Aulabaugh; Rajiv Chopra; Rebecca Cowling; John W Ellingboe; Kristi Y Fan; Boyd L Harrison; Yun Hu; Steve Jacobsen; Guixian Jin; Laura Lin; Frank Lovering; Michael S Malamas; Mark L Stahl; James Strand; Mohani N Sukhdeo; Kristine Svenson; M James Turner; Erik Wagner; Junjun Wu; Ping Zhou; Jonathan Bard
Acylguanidines as small-molecule beta-secretase inhibitors.
Journal of medicinal chemistry 2006;49(21):6158-61.
2006: Kristie Bridges; Rajiv Chopra; Laura Lin; Kristine Svenson; Amy Tam; Guixian Jin; Rebecca Cowling; Frank Lovering; Tatos N Akopian; Elizabeth DiBlasio-Smith; Bethany Annis-Freeman; Tod H Marvell; Edward R LaVallie; Richard Zollner; Jonathan Bard; William S Somers; Mark L Stahl; Ron Kriz
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Peptides 2006;27(7):1877-85.
2006: Ariamala Gopalsamy; Rajiv Chopra; Kitae Lim; Gregory Ciszewski; Mengxiao Shi; Kevin Joseph Curran; Steven F Sukits; Kristine Svenson; Jonathan Bard; John W Ellingboe; Atul Agarwal; Girija Krishnamurthy; Anita Y M Howe; Mark Orlowski; Boris Feld; John O'Connell; Tarek S Mansour
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Journal of medicinal chemistry 2006;49(11):3052-5.
2006: Youjun Yang; Anatoly Severin; Rajiv Chopra; Girija Krishnamurthy; Guy Singh; William Hu; David Keeney; Kristine Svenson; Peter J Petersen; Pornpen Labthavikul; David M Shlaes; Beth A Rasmussen; Amedeo A Failli; Jay S Shumsky; Kristina M K Kutterer; Adam Gilbert; Tarek S Mansour
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
Antimicrobial agents and chemotherapy 2006;50(2):556-64.
2005: Andrew Fensome; Reinhold Bender; Rajiv Chopra; Jeff Cohen; Mark A Collins; Valerie Hudak; Karl Malakian; Susan Lockhead; Andrea M Olland; Kristine Svenson; Eugene A Terefenko; Rayomand J Unwalla; James M Wilhelm; Scott Wolfrom; Yuan Zhu; Zhiming Zhang; Puwen Zhang; Richard Winneker; Jay Wrobel
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Journal of medicinal chemistry 2005;48(16):5092-5.
2005: Zhiming Zhang; Andrea M Olland; Yuan Zhu; Jeff Cohen; Tom Berrodin; Susan Chippari; Chandrasekaran Appavu; Shen Li; James Wilhem; Rajiv Chopra; Andrew Fensome; Puwen Zhang; Jay Wrobel; Rayomand J Unwalla; C Richard Lyttle; Richard Winneker
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
The Journal of biological chemistry 2005;280(31):28468-75.
2004: Baihua Hu; Kristi Yi Fan; Kristie Bridges; Rajiv Chopra; Frank Lovering; Derek Cole; Ping Zhou; John W Ellingboe; Guixian Jin; Rebecca Cowling; Jonathan Bard
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(13):3457-60.
2004: Cuihua Liu; Rajiv Chopra; Stephen Swanberg; Stephane Olland; John O'Connell; Steve Herrmann
Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.
The Journal of biological chemistry 2004;279(11):10738-46.
2002: Andrea M Olland; Kathryn W Underwood; Robert Czerwinski; Mei-Chu Lo; Ann Aulabaugh; Jonathan Bard; Mark L Stahl; William S Somers; Francis X Sullivan; Rajiv Chopra
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
The Journal of biological chemistry 2002;277(5):3698-707.