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Kirill Alexandrov

Research Profile

Chemicals & Drugs

Physiology

Protein Prenylation

Concepts & Ideas

Phenomena

Protein Binding

Procedures

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Céline Deraeve; Raffaella DiLucrezia; Roger S Goody; Zhong Guo; Sascha Menninger; E Anouk Stigter; Herbert Waldmann; Stefan Wetzel; Alexander Wolf; Kirill Alexandrov; Wulf Blankenfeldt; Robin Bon; Axel Choidas; Yao-Wen Wu
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
Robin Bon; Zhong Guo; E Anouk Stigter; Stefan Wetzel; Sascha Menninger; Alexander Wolf; Axel Choidas; Kirill Alexandrov; Wulf Blankenfeldt; Roger S Goody; Herbert Waldmann
Structure-guided development of selective RabGGTase inhibitors.
Susanna Kushnir; Ion Cristian Cirstea; Lyudmyla Basiliya; Nataliya Lupilova; Reinhard Breitling; Kirill Alexandrov
Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.

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All Publications

2012: Céline Deraeve; Raffaella DiLucrezia; Roger S Goody; Zhong Guo; Sascha Menninger; E Anouk Stigter; Herbert Waldmann; Stefan Wetzel; Alexander Wolf; Kirill Alexandrov; Wulf Blankenfeldt; Robin Bon; Axel Choidas; Yao-Wen Wu
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
Journal of the American Chemical Society 2012;134(17):7384-91.
2011: Robin Bon; Zhong Guo; E Anouk Stigter; Stefan Wetzel; Sascha Menninger; Alexander Wolf; Axel Choidas; Kirill Alexandrov; Wulf Blankenfeldt; Roger S Goody; Herbert Waldmann
Structure-guided development of selective RabGGTase inhibitors.
Angewandte Chemie (International ed. in English) 2011;50(21):4957-61.
2011: Susanna Kushnir; Ion Cristian Cirstea; Lyudmyla Basiliya; Nataliya Lupilova; Reinhard Breitling; Kirill Alexandrov
Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.
Molecular and biochemical parasitology 2011;176(2):69-79.
2010: Emerich Mihai Gazdag; Ion Cristian Cirstea; Reinhard Breitling; Julius Lukes; Wulf Blankenfeldt; Kirill Alexandrov
Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 8):871-7.
2010: Yao-Wen Wu; Lena K Oesterlin; Kui-Thong Tan; Herbert Waldmann; Kirill Alexandrov; Roger S Goody
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes.
Nature chemical biology 2010;6(7):534-40.
2009: Kui-Thong Tan; Ester Guiu-Rozas; Robin Bon; Zhong Guo; Christine Delon; Stefan Wetzel; Sabine Arndt; Kirill Alexandrov; Herbert Waldmann; Roger S Goody; Yao-Wen Wu; Wulf Blankenfeldt
Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.
Journal of medicinal chemistry 2009;52(24):8025-37.
2009: Robert Rucktäschel; Sven Thoms; Vadim Sidorovitch; André Halbach; Markos Pechlivanis; Rudolf Volkmer; Kirill Alexandrov; Jürgen Kuhlmann; Hanspeter Rottensteiner; Ralf Erdmann
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.
The Journal of biological chemistry 2009;284(31):20885-96.
2009: Nathalie Bleimling; Kirill Alexandrov; Roger Goody; Aymelt Itzen
Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli.
Protein expression and purification 2009;65(2):190-5.
2009: Yao-Wen Wu; Roger S Goody; Ruben Abagyan; Kirill Alexandrov
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.
The Journal of biological chemistry 2009;284(19):13185-92.
2009: Uyen T T Nguyen; Zhong Guo; Christine Delon; Yaowen Wu; Celine Deraeve; Benjamin Fränzel; Robin Bon; Wulf Blankenfeldt; Roger S Goody; Herbert Waldmann; Dirk Wolters; Kirill Alexandrov
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.
Nature chemical biology 2009;5(4):227-35.
2009: Tim Bergbrede; Nam Chuky; Stefan Schoebel; Wulf Blankenfeldt; Matthias Geyer; Evelyn Fuchs; Roger S Goody; Francis Barr; Kirill Alexandrov
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains.
The Journal of biological chemistry 2009;284(5):2628-35.
2008: Zhong Guo; Yao-Wen Wu; Debapratim Das; Christine Delon; Janinna Cramer; Shen Yu; Sandra Thuns; Nataliya Lupilova; Herbert Waldmann; Luc Brunsveld; Roger S Goody; Kirill Alexandrov; Wulf Blankenfeldt
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal 2008;27(18):2444-56.
2008: Zhong Guo; Yao-Wen Wu; Kui-Thong Tan; Robin Bon; Ester Guiu-Rozas; Christine Delon; T Uyen Nguyen; Stefan Wetzel; Sabine Arndt; Roger S Goody; Wulf Blankenfeldt; Kirill Alexandrov; Herbert Waldmann
Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angewandte Chemie (International ed. in English) 2008;47(20):3747-50.
2007: Sergei Mureev; Susanna Kushnir; Alexander A Kolesnikov; Reinhard Breitling; Kirill Alexandrov
Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers.
Molecular and biochemical parasitology 2007;155(2):71-83.
2007: Yao-Wen Wu; Kui-Thong Tan; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12294-9.
2007: Uyen T T Nguyen; Janina Cramer; Joaquin Gomis; Reinhard Reents; Marta Gutierrez-Rodriguez; Roger S Goody; Kirill Alexandrov; Herbert Waldmann
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.
Chembiochem : a European journal of chemical biology 2007;8(4):408-23.
2007: Yao-Wen Wu; Kirill Alexandrov; Luc Brunsveld
Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase.
Nature protocols 2007;2(11):2704-11.
2006: Yao-Wen Wu; Herbert Waldmann; Reinhard Reents; Frank H Ebetino; Roger S Goody; Kirill Alexandrov
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase.
Chembiochem : a European journal of chemical biology 2006;7(12):1859-61.
2006: Yoann Marsac; Janina Cramer; Diana Olschewski; Kirill Alexandrov; Christian F W Becker
Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.
Bioconjugate chemistry 2006;17(6):1492-8.
2006: Luc Brunsveld; Jürgen Kuhlmann; Kirill Alexandrov; Alfred Wittinghofer; Roger S Goody; Herbert Waldmann
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
2006: Anja Watzke; Marta Gutierrez-Rodriguez; Maja Köhn; Ron Wacker; Hendrik Schroeder; Rolf Breinbauer; Jürgen Kuhlmann; Kirill Alexandrov; Christof M Niemeyer; Roger S Goody; Herbert Waldmann
A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Bioorganic & medicinal chemistry 2006;14(18):6288-306.
2006: Aline Dantas de Araújo; Jose M Palomo; Janina Cramer; Oliver Seitz; Kirill Alexandrov; Herbert Waldmann
Diels-Alder ligation of peptides and proteins.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(23):6095-109.
2006: Anca Niculae; Peter Bayer; Ion Cirstea; Tim Bergbrede; Regina Pietrucha; Mathias Gruen; Reinhard Breitling; Kirill Alexandrov
Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae.
Protein expression and purification 2006;48(2):167-72.
2006: Julius Lukes; Zdenek Paris; Sandesh Regmi; Reinhard Breitling; Sergey Mureev; Susanna Kushnir; Konstantin Pyatkov; Milan Jirků; Kirill Alexandrov
Translational initiation in Leishmania tarentolae and Phytomonas serpens (Kinetoplastida) is strongly influenced by pre-ATG triplet and its 5' sequence context.
Molecular and biochemical parasitology 2006;148(2):125-32.
2006: Christian F W Becker; Ralf Seidel; Michael Jahnz; Kirsten Bacia; Thomas Niederhausen; Kirill Alexandrov; Petra Schwille; Roger S Goody; Martin Engelhard
C-terminal fluorescence labeling of proteins for interaction studies on the single-molecule level.
Chembiochem : a European journal of chemical biology 2006;7(6):891-5.
2006: Susanna Kushnir; Yoann Marsac; Reinhard Breitling; Igor Granovsky; Vera Brok-Volchanskaya; Roger S Goody; Christian F W Becker; Kirill Alexandrov
Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation.
Bioconjugate chemistry 2006;17(3):610-7.
2006: Aymelt Itzen; Olena Pylypenko; Roger S Goody; Kirill Alexandrov; Alexey Rak
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.
The EMBO journal 2006;25(7):1445-55.
2006: Beatrice Dursina; Reinhard Reents; Christine Delon; Yaowen Wu; Mahesh Kulharia; Michael Thutewohl; Alexei Veligodsky; Alexandr Kalinin; Vladimir Evstifeev; Doina Ciobanu; Stefan E Szedlacsek; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.
Journal of the American Chemical Society 2006;128(9):2822-35.
2006: Anja Watzke; Maja Köhn; Marta Gutierrez-Rodriguez; Ron Wacker; Hendrik Schröder; Rolf Breinbauer; Jürgen Kuhlmann; Kirill Alexandrov; Christof M Niemeyer; Roger S Goody; Herbert Waldmann
Site-selective protein immobilization by Staudinger ligation.
Angewandte Chemie (International ed. in English) 2006;45(9):1408-12.
2006: Olena Pylypenko; Alexey Rak; Thomas Durek; Susanna Kushnir; Beatrice Dursina; Nicolas H Thomae; Alexandru-Tudor Constantinescu; Luc Brunsveld; Anja Watzke; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.
The EMBO journal 2006;25(1):13-23.
2005: Aline Dantas de Araújo; Jose M Palomo; Janina Cramer; Maja Köhn; Hendrik Schröder; Ron Wacker; Christof Niemeyer; Kirill Alexandrov; Herbert Waldmann
Diels-Alder ligation and surface immobilization of proteins.
Angewandte Chemie (International ed. in English) 2005;45(2):296-301.
2005: Tim Bergbrede; Olena Pylypenko; Alexey Rak; Kirill Alexandrov
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.
Journal of structural biology 2005;152(3):235-8.
2005: Roger S Goody; Alexey Rak; Kirill Alexandrov
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments.
Cellular and molecular life sciences : CMLS 2005;62(15):1657-70.
2005: Susanna Kushnir; Klaus Gase; Reinhard Breitling; Kirill Alexandrov
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae.
Protein expression and purification 2005;42(1):37-46.
2005: Luc Brunsveld; Anja Watzke; Thomas Durek; Kirill Alexandrov; Roger S Goody; Herbert Waldmann
Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(9):2756-72.
2005: Anja Watzke; Luc Brunsveld; Thomas Durek; Kirill Alexandrov; Alexey Rak; Roger S Goody; Herbert Waldmann
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.
Organic & biomolecular chemistry 2005;3(7):1157-64.
2005: Roger S Goody; Thomas Durek; Herbert Waldmann; Luc Brunsveld; Kirill Alexandrov
Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases.
Methods in enzymology 2005;403():29-42.
2005: Beatrice Dursina; Reinhard Reents; Anca Niculae; Alexei Veligodsky; Reinhard Breitling; Konstantin Pyatkov; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins.
Protein expression and purification 2005;39(1):71-81.
2004: Thomas Durek; Kirill Alexandrov; Roger S Goody; Alexandra Hildebrand; Ines Heinemann; Herbert Waldmann
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.
Journal of the American Chemical Society 2004;126(50):16368-78.
2004: Alexey Rak; Olena Pylypenko; Anca Niculae; Konstantin Pyatkov; Roger S Goody; Kirill Alexandrov
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Cell 2004;117(6):749-60.
2004: Thomas Durek; Roger S Goody; Kirill Alexandrov
In vitro semisynthesis and applications of C-terminally modified rab proteins.
Methods in molecular biology (Clifton, N.J.) 2004;283():233-44.
2003: Alexey Rak; Olena Pylypenko; Thomas Durek; Anja Watzke; Susanna Kushnir; Luc Brunsveld; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.
Science (New York, N.Y.) 2003;302(5645):646-50.
2003: Olena Pylypenko; Alexey Rak; Reinhard Reents; Anca Niculae; Vadim Sidorovitch; Maria Daniela Cioaca; Ekaterina Bessolitsyna; Nicolas H Thomä; Herbert Waldmann; Ilme Schlichting; Roger S Goody; Kirill Alexandrov
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell 2003;11(2):483-94.
2003: Alexey Rak; Olena Pylypenko; Anca Niculae; Roger S Goody; Kirill Alexandrov
Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1.
Journal of structural biology 2003;141(1):93-5.
2002: Vadim Sidorovitch; Anca Niculae; Natalia Kan; Alice-Corina Ceacareanu; Kirill Alexandrov
Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.
Protein expression and purification 2002;26(1):50-8.
2002: Reinhard Breitling; Susanne Klingner; Nico Callewaert; Regina Pietrucha; Anett Geyer; Gunter Ehrlich; Regina Hartung; Angelika Müller; Roland Contreras; Stephen M Beverley; Kirill Alexandrov
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production.
Protein expression and purification 2002;25(2):209-18.
2002: Alexey Rak; Anca Niculae; Alexandr Kalinin; Nicolas H Thomä; Vadim Sidorovitch; Roger S Goody; Kirill Alexandrov
In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex.
Protein expression and purification 2002;25(1):23-30.
2002: Beatrice Dursina; Nicolas H Thomä; Vadim Sidorovitch; Anca Niculae; Andrei Iakovenko; Alexey Rak; Stefan Albert; Alice-Corina Ceacareanu; Ralf Kölling; Christian Herrmann; Roger S Goody; Kirill Alexandrov
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.
Biochemistry 2002;41(21):6805-16.
2002: Kirill Alexandrov; Ines Heinemann; Thomas Durek; Vadim Sidorovitch; Roger S Goody; Herbert Waldmann
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.
Journal of the American Chemical Society 2002;124(20):5648-9.
2002: Roger S Goody; Kirill Alexandrov; Martin Engelhard
Combining chemical and biological techniques to produce modified proteins.
Chembiochem : a European journal of chemical biology 2002;3(5):399-403.
2002: Alexandru-Tudor Constantinescu; Alexey Rak; Kirill Alexandrov; Heike Esters; Roger S Goody; Axel J Scheidig
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.
Structure (London, England : 1993) 2002;10(4):569-79.
2001: Nicolas H Thomä; Andrei Iakovenko; Roger S Goody; Kirill Alexandrov
Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.
The Journal of biological chemistry 2001;276(52):48637-43.
2001: Nicolas H Thomä; Anca Niculae; Roger S Goody; Kirill Alexandrov
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.
The Journal of biological chemistry 2001;276(52):48631-6.
2001: Alexey Rak; Reinhard Reents; Olena Pylypenko; Anca Niculae; Vadim Sidorovitch; Nicolas H Thomä; Herbert Waldmann; Ilme Schlichting; Roger S Goody; Kirill Alexandrov
Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Journal of structural biology 2001;136(2):158-61.
2001: Heike Esters; Kirill Alexandrov; Andrei Iakovenko; T Ivanova; Nicolas H Thomä; Vladimir Rybin; Marino Zerial; Axel J Scheidig; Roger S Goody
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.
Journal of molecular biology 2001;310(1):141-56.
2001: Alexandr Kalinin; Nicolas H Thomä; Andrei Iakovenko; Ines Heinemann; E Rostkova; A T Constantinescu; Kirill Alexandrov
Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins.
Protein expression and purification 2001;22(1):84-91.
2001: EM Merzlyak; Vyacheslav Yurchenko; Alexander A Kolesnikov; Kirill Alexandrov; Sergei A Podlipaev; Dmitri A Maslov
Diversity and phylogeny of insect trypanosomatids based on small subunit rRNA genes: polyphyly of Leptomonas and Blastocrithidia.
The Journal of eukaryotic microbiology 2001;48(2):161-9.
2001: Nicolas H Thomä; Andrei Iakovenko; Alexandr Kalinin; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.
Biochemistry 2001;40(1):268-74.
2001: Kirill Alexandrov; Axel J Scheidig; Roger S Goody
Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase.
Methods in enzymology 2001;329():14-31.
2000: Nicolas H Thomä; Andrei Iakovenko; D Owen; A S Scheidig; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II.
Biochemistry 2000;39(39):12043-52.
2000: Alexey Rak; R Fedorov; Kirill Alexandrov; Stefan Albert; Roger S Goody; Dieter Gallwitz; Axel J Scheidig
Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
The EMBO journal 2000;19(19):5105-13.
2000: Heike Esters; Kirill Alexandrov; Alexandru-Tudor Constantinescu; Roger S Goody; Axel J Scheidig
High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.
Journal of molecular biology 2000;298(1):111-21.
2000: Andrei Iakovenko; E Rostkova; EM Merzlyak; A M Hillebrand; Nicolas H Thomä; Roger S Goody; Kirill Alexandrov
Semi-synthetic Rab proteins as tools for studying intermolecular interactions.
FEBS letters 2000;468(2-3):155-8.
1999: Kirill Alexandrov; I Simon; Vyacheslav Yurchenko; Andrei Iakovenko; E Rostkova; Axel J Scheidig; Roger S Goody
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.
European journal of biochemistry / FEBS 1999;265(1):160-70.
1998: Kirill Alexandrov; I Simon; Andrei Iakovenko; B Holz; Roger S Goody; Axel J Scheidig
Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates.
FEBS letters 1998;425(3):460-4.
1998: AT Jones; Ian Mills; Axel J Scheidig; Kirill Alexandrov; Michael J Clague
Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5.
Molecular biology of the cell 1998;9(2):323-32.