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Kirill Alexandrov
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Research Profile (preview)
Chemicals & Drugs
Physiology
Phenomena
Concepts & Ideas
Procedures
Genes & Molecular Sequences
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Network (preview)
44
Goody, Roger
24
Waldmann, Herbert
14
Rak, Alexey
11
Thomä, Nicolas
10
Niculae, Anca
9
Iakovenko, Andrei
8
Brunsveld, Luc
8
Durek, Thomas
8
Scheidig, Axel
8
Pylypenko, Olena
7
Sidorovitch, Vadim
7
Breitling, Reinhard
6
Kushnir, Susanna
6
Watzke, Anja
6
Wu, Yao-Wen
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Geonetwork of Kirill Alexandrov (preview)
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All Publications
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2009: Rucktäschel Robert; Thoms Sven; Sidorovitch Vadim; Halbach Andre; Pechlivanis Markos; Volkmer Rudolf; Alexandrov Kirill; Kuhlmann Jürgen; Rottensteiner Hanspeter; Erdmann Ralf
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.
The Journal of biological chemistry 2009;284(31):20885-96.
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2009: Bleimling Nathalie; Alexandrov Kirill; Goody Roger; Itzen Aymelt
Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli.
Protein expression and purification 2009;65(2):190-5.
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2009: Wu Yao-Wen; Goody Roger S; Abagyan Ruben; Alexandrov Kirill
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.
The Journal of biological chemistry 2009;284(19):13185-92.
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2009: Nguyen Uyen T T; Guo Zhong; Delon Christine; Wu Yaowen; Deraeve Celine; Fränzel Benjamin; Bon Robin S; Blankenfeldt Wulf; Goody Roger S; Waldmann Herbert; Wolters Dirk; Alexandrov Kirill
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.
Nature chemical biology 2009;5(4):227-35.
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2009: Bergbrede Tim; Chuky Nam; Schoebel Stefan; Blankenfeldt Wulf; Geyer Matthias; Fuchs Evelyn; Goody Roger S; Barr Francis; Alexandrov Kirill
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains.
The Journal of biological chemistry 2009;284(5):2628-35.
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2008: Guo Zhong; Wu Yao-Wen; Das Debapratim; Delon Christine; Cramer Janinna; Yu Shen; Thuns Sandra; Lupilova Nataliya; Waldmann Herbert; Brunsveld Luc; Goody Roger S; Alexandrov Kirill; Blankenfeldt Wulf
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal 2008;27(18):2444-56.
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2008: Guo Zhong; Wu Yao-Wen; Tan Kui-Thong; Bon Robin S; Guiu-Rozas Ester; Delon Christine; Nguyen T Uyen; Wetzel Stefan; Arndt Sabine; Goody Roger S; Blankenfeldt Wulf; Alexandrov Kirill; Waldmann Herbert
Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angewandte Chemie (International ed. in English) 2008;47(20):3747-50.
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2007: Mureev Sergei; Kushnir Susanna; Kolesnikov Alexander A; Breitling Reinhard; Alexandrov Kirill
Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers.
Molecular and biochemical parasitology 2007;155(2):71-83.
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2007: Wu Yao-Wen; Tan Kui-Thong; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12294-9.
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2007: Nguyen Uyen T T; Cramer Janina; Gomis Joaquin; Reents Reinhard; Gutierrez-Rodriguez Marta; Goody Roger S; Alexandrov Kirill; Waldmann Herbert
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.
Chembiochem : a European journal of chemical biology 2007;8(4):408-23.
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2007: Wu Yao-Wen; Alexandrov Kirill; Brunsveld Luc
Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase.
Nature protocols 2007;2(11):2704-11.
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2006: Wu Yao-Wen; Waldmann Herbert; Reents Reinhard; Ebetino Frank H; Goody Roger S; Alexandrov Kirill
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase.
Chembiochem : a European journal of chemical biology 2006;7(12):1859-61.
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2006: Marsac Yoann; Cramer Janina; Olschewski Diana; Alexandrov Kirill; Becker Christian F W
Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.
Bioconjugate chemistry 2006;17(6):1492-8.
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2006: Brunsveld Luc; Kuhlmann Jürgen; Alexandrov Kirill; Wittinghofer Alfred; Goody Roger S; Waldmann Herbert
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
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2006: Watzke Anja; Gutierrez-Rodriguez Marta; Köhn Maja; Wacker Ron; Schroeder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Bioorganic & medicinal chemistry 2006;14(18):6288-306.
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2006: de Araújo Aline Dantas; Palomo Jose M; Cramer Janina; Seitz Oliver; Alexandrov Kirill; Waldmann Herbert
Diels-Alder ligation of peptides and proteins.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(23):6095-109.
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2006: Niculae Anca; Bayer Peter; Cirstea Ion; Bergbrede Tim; Pietrucha Regina; Gruen Mathias; Breitling Reinhard; Alexandrov Kirill
Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae.
Protein expression and purification 2006;48(2):167-72.
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2006: Lukes Julius; Paris Zdenek; Regmi Sandesh; Breitling Reinhard; Mureev Sergey; Kushnir Susanna; Pyatkov Konstantin; Jirku Milan; Alexandrov Kirill A
Translational initiation in Leishmania tarentolae and Phytomonas serpens (Kinetoplastida) is strongly influenced by pre-ATG triplet and its 5' sequence context.
Molecular and biochemical parasitology 2006;148(2):125-32.
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2006: Becker Christian F W; Seidel Ralf; Jahnz Michael; Bacia Kirsten; Niederhausen Thomas; Alexandrov Kirill; Schwille Petra; Goody Roger S; Engelhard Martin
C-terminal fluorescence labeling of proteins for interaction studies on the single-molecule level.
Chembiochem : a European journal of chemical biology 2006;7(6):891-5.
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2006: Kushnir Susanna; Marsac Yoann; Breitling Reinhard; Granovsky Igor; Brok-Volchanskaya Vera; Goody Roger S; Becker Christian F W; Alexandrov Kirill
Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation.
Bioconjugate chemistry 2006;17(3):610-7.
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2006: Itzen Aymelt; Pylypenko Olena; Goody Roger S; Alexandrov Kirill; Rak Alexey
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.
The EMBO journal 2006;25(7):1445-55.
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2006: Dursina Beatrice; Reents Reinhard; Delon Christine; Wu Yaowen; Kulharia Mahesh; Thutewohl Michael; Veligodsky Alexei; Kalinin Alexandr; Evstifeev Vladimir; Ciobanu Doina; Szedlacsek Stefan E; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.
Journal of the American Chemical Society 2006;128(9):2822-35.
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2006: Watzke Anja; Köhn Maja; Gutierrez-Rodriguez Marta; Wacker Ron; Schröder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
Site-selective protein immobilization by Staudinger ligation.
Angewandte Chemie (International ed. in English) 2006;45(9):1408-12.
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2006: Pylypenko Olena; Rak Alexey; Durek Thomas; Kushnir Susanna; Dursina Beatrice E; Thomae Nicolas H; Constantinescu Alexandru T; Brunsveld Luc; Watzke Anja; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.
The EMBO journal 2006;25(1):13-23.
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2005: Bergbrede Tim; Pylypenko Olena; Rak Alexey; Alexandrov Kirill
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.
Journal of structural biology 2005;152(3):235-8.
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2005: de Araújo Aline Dantas; Palomo Jose M; Cramer Janina; Köhn Maja; Schröder Hendrik; Wacker Ron; Niemeyer Christof; Alexandrov Kirill; Waldmann Herbert
Diels-Alder ligation and surface immobilization of proteins.
Angewandte Chemie (International ed. in English) 2005;45(2):296-301.
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2005: Goody R S; Rak A; Alexandrov K
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments.
Cellular and molecular life sciences : CMLS 2005;62(15):1657-70.
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2005: Kushnir Susanna; Gase Klaus; Breitling Reinhard; Alexandrov Kirill
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae.
Protein expression and purification 2005;42(1):37-46.
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2005: Watzke Anja; Brunsveld Luc; Durek Thomas; Alexandrov Kirill; Rak Alexey; Goody Roger S; Waldmann Herbert
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.
Organic & biomolecular chemistry 2005;3(7):1157-64.
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2005: Brunsveld Luc; Watzke Anja; Durek Thomas; Alexandrov Kirill; Goody Roger S; Waldmann Herbert
Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(9):2756-72.
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2005: Dursina Beatrice-Elena; Reents Reinhard; Niculae Anca; Veligodsky Alexei; Breitling Reinhard; Pyatkov Konstantin; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins.
Protein expression and purification 2005;39(1):71-81.
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2005: Goody Roger S; Durek Thomas; Waldmann Herbert; Brunsveld Lucas; Alexandrov Kirill
Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases.
Methods in enzymology 2005;403():29-42.
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2004: Durek Thomas; Alexandrov Kirill; Goody Roger S; Hildebrand Alexandra; Heinemann Ines; Waldmann Herbert
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.
Journal of the American Chemical Society 2004;126(50):16368-78.
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2004: Rak Alexey; Pylypenko Olena; Niculae Anca; Pyatkov Konstantin; Goody Roger S; Alexandrov Kirill
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Cell 2004;117(6):749-60.
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2004: Durek Thomas; Goody Roger S; Alexandrov Kirill
In vitro semisynthesis and applications of C-terminally modified rab proteins.
Methods in molecular biology (Clifton, N.J.) 2004;283():233-44.
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2003: Rak Alexey; Pylypenko Olena; Durek Thomas; Watzke Anja; Kushnir Susanna; Brunsveld Lucas; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.
Science (New York, N.Y.) 2003;302(5645):646-50.
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2003: Pylypenko Olena; Rak Alexey; Reents Reinhard; Niculae Anca; Sidorovitch Vadim; Cioaca Maria Daniela; Bessolitsyna Ekaterina; Thomä Nicolas H; Waldmann Herbert; Schlichting Ilme; Goody Roger S; Alexandrov Kirill
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell 2003;11(2):483-94.
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2003: Rak Alexey; Pylypenko Olena; Niculae Anca; Goody Roger S; Alexandrov Kirill
Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1.
Journal of structural biology 2003;141(1):93-5.
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2002: Sidorovitch Vadim; Niculae Anca; Kan Natalia; Ceacareanu Alice-Corina; Alexandrov Kirill
Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.
Protein expression and purification 2002;26(1):50-8.
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2002: Breitling Reinhard; Klingner Susanne; Callewaert Nico; Pietrucha Regina; Geyer Anett; Ehrlich Gunter; Hartung Regina; Müller Angelika; Contreras Roland; Beverley Stephen M; Alexandrov Kirill
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production.
Protein expression and purification 2002;25(2):209-18.
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2002: Rak Alexey; Niculae Anca; Kalinin Alexandr; Thomä Nicolas H; Sidorovitch Vadim; Goody Roger S; Alexandrov Kirill
In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex.
Protein expression and purification 2002;25(1):23-30.
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2002: Dursina Beatrice; Thomä Nicolas H; Sidorovitch Vadim; Niculae Anca; Iakovenko Andrei; Rak Alexy; Albert Stefan; Ceacareanu Alice-Corina; Kölling Ralf; Herrmann Christian; Goody Roger S; Alexandrov Kirill
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.
Biochemistry 2002;41(21):6805-16.
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2002: Alexandrov Kirill; Heinemann Ines; Durek Thomas; Sidorovitch Vadim; Goody Roger S; Waldmann Herbert
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.
Journal of the American Chemical Society 2002;124(20):5648-9.
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2002: Goody Roger S; Alexandrov Kirill; Engelhard Martin
Combining chemical and biological techniques to produce modified proteins.
Chembiochem : a European journal of chemical biology 2002;3(5):399-403.
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2002: Constantinescu Alexandru-Tudor; Rak Alexey; Alexandrov Kirill; Esters Heike; Goody Roger S; Scheidig Axel J
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.
Structure (London, England : 1993) 2002;10(4):569-79.
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2001: Thomä N H; Iakovenko A; Goody R S; Alexandrov K
Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.
The Journal of biological chemistry 2001;276(52):48637-43.
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2001: Thomä N H; Niculae A; Goody R S; Alexandrov K
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.
The Journal of biological chemistry 2001;276(52):48631-6.
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2001: Rak A; Reents R; Pylypenko O; Niculae A; Sidorovitch V; Thomä N H; Waldmann H; Schlichting I; Goody R S; Alexandrov K
Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Journal of structural biology 2001;136(2):158-61.
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2001: Esters H; Alexandrov K; Iakovenko A; Ivanova T; Thomä N; Rybin V; Zerial M; Scheidig A J; Goody R S
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.
Journal of molecular biology 2001;310(1):141-56.
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2001: Kalinin A; Thomä N H; Iakovenko A; Heinemann I; Rostkova E; Constantinescu A T; Alexandrov K
Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins.
Protein expression and purification 2001;22(1):84-91.
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2001: Merzlyak E; Yurchenko V; Kolesnikov A A; Alexandrov K; Podlipaev S A; Maslov D A
Diversity and phylogeny of insect trypanosomatids based on small subunit rRNA genes: polyphyly of Leptomonas and Blastocrithidia.
The Journal of eukaryotic microbiology 2001;48(2):161-9.
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2001: Thomä N H; Iakovenko A; Kalinin A; Waldmann H; Goody R S; Alexandrov K
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.
Biochemistry 2001;40(1):268-74.
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2001: Alexandrov K; Scheidig A J; Goody R S
Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase.
Methods in enzymology 2001;329():14-31.
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2000: Rak A; Fedorov R; Alexandrov K; Albert S; Goody R S; Gallwitz D; Scheidig A J
Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
The EMBO journal 2000;19(19):5105-13.
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2000: Thomä N H; Iakovenko A; Owen D; Scheidig A S; Waldmann H; Goody R S; Alexandrov K
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II.
Biochemistry 2000;39(39):12043-52.
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2000: Esters H; Alexandrov K; Constantinescu A T; Goody R S; Scheidig A J
High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.
Journal of molecular biology 2000;298(1):111-21.
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2000: Iakovenko A; Rostkova E; Merzlyak E; Hillebrand A M; Thomä N H; Goody R S; Alexandrov K
Semi-synthetic Rab proteins as tools for studying intermolecular interactions.
FEBS letters 2000;468(2-3):155-8.
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1999: Alexandrov K; Simon I; Yurchenko V; Iakovenko A; Rostkova E; Scheidig A J; Goody R S
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.
European journal of biochemistry / FEBS 1999;265(1):160-70.
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1998: Alexandrov K; Simon I; Iakovenko A; Holz B; Goody R S; Scheidig A J
Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates.
FEBS letters 1998;425(3):460-4.
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1998: Jones A T; Mills I G; Scheidig A J; Alexandrov K; Clague M J
Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5.
Molecular biology of the cell 1998;9(2):323-32.
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