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Michel Chrétien

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Chemicals & Drugs

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Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Francine Sirois; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.
Michel Chrétien
My road to Damascus: how I converted to the prohormone theory and the proprotein convertases.
Francine Sirois; KK Nkongolo; Michel Chrétien; Krista A Currie; Nadine Kaefer; Majambu Mbikay
Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample.

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All Publications

2013: Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Francine Sirois; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.
Lipids in health and disease 2013;12():70.
2012: Michel Chrétien
My road to Damascus: how I converted to the prohormone theory and the proprotein convertases.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2012;90(6):750-68.
2012: Francine Sirois; KK Nkongolo; Michel Chrétien; Krista A Currie; Nadine Kaefer; Majambu Mbikay
Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample.
Journal of community genetics 2012;3(4):319-22.
2011: Majambu Mbikay; Kabwe K Nkongolo; Francine Sirois; Ajoy Basak; Michel Chrétien
Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.
Molecular genetics and metabolism 2011;104(4):682-7.
2011: Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Nabil G Seidah; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.
Clinical chemistry 2011;57(10):1415-23.
2011: Nicholas Denis; Heather Palmer-Smith; Fred Elisma; Alia Busuttil; Theodore Glenn Wright; Maroun Bou Khalil; Annik Prat; Nabil G Seidah; Michel Chrétien; Janice Mayne; Daniel Figeys
Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells.
Journal of proteome research 2011;10(4):2011-26.
2011: Jeffrey Gagnon; Janice Mayne; Andrew Chen; Angela Raymond; John Woulfe; Majambu Mbikay; Michel Chrétien
PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.
Life sciences 2011;88(5-6):212-7.
2010: Younes Anini; J Mayne; J Gagnon; J Sherbafi; A Chen; N Kaefer; Michel Chrétien; Majambu Mbikay
Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain.
International journal of obesity (2005) 2010;34(11):1599-607.
2008: Michel Chrétien; Nabil G Seidah; Ajoy Basak; Majambu Mbikay
Proprotein convertases as therapeutic targets.
Expert opinion on therapeutic targets 2008;12(10):1289-300.
2008: Thilina Dewpura; Angela Raymond; Josée Hamelin; Nabil G Seidah; Majambu Mbikay; Michel Chrétien; Janice Mayne
PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.
The FEBS journal 2008;275(13):3480-93.
2008: Fumin Dong; Liming Ma; Michel Chrétien; Majambu Mbikay
Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model.
Methods in molecular biology (Clifton, N.J.) 2008;410():111-22.
2008: Janice Mayne; Thilina Dewpura; Angela Raymond; Marion Cousins; Anna Chaplin; Karen A Lahey; Stephen A Lahaye; Majambu Mbikay; Teik Chye Ooi; Michel Chrétien
Plasma PCSK9 levels are significantly modified by statins and fibrates in humans.
Lipids in health and disease 2008;7():22.
2007: Janice Mayne; Angela Raymond; Anna Chaplin; Marion Cousins; Nadine Kaefer; Charles Gyamera-Acheampong; Nabil G Seidah; Majambu Mbikay; Michel Chrétien; Teik Chye Ooi
Plasma PCSK9 levels correlate with cholesterol in men but not in women.
Biochemical and biophysical research communications 2007;361(2):451-6.
2007: Ajoy Basak; Abhijit Mitra; Sarmistha Basak; Carolyn Pasko; Michel Chrétien; Pamela Seaton
A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation.
Chembiochem : a European journal of chemical biology 2007;8(9):1029-37.
2007: Majambu Mbikay; Gilles Croissandeau; Francine Sirois; Younes Anini; Janice Mayne; Nabil G Seidah; Michel Chrétien
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.
Developmental biology 2007;306(2):584-98.
2007: Majambu Mbikay; Janice Mayne; Nabil G Seidah; Michel Chrétien
Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.
Medical hypotheses 2007;69(5):1010-7.
2006: Gilles Croissandeau; Flora Wahnon; Kiran Yashpal; Nabil G Seidah; Terence J Coderre; Michel Chrétien; Majambu Mbikay
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.
Neuroscience letters 2006;406(1-2):71-5.
2006: Gunther Schmidt; Francine Sirois; Younes Anini; Lisa M Kauri; Charles Gyamera-Acheampong; Eckart Fleck; Fraser W Scott; Michel Chrétien; Majambu Mbikay
Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).
Diabetes 2006;55(2):452-9.
2006: Rachid Essalmani; Josée Hamelin; Jadwiga Marcinkiewicz; Ann Chamberland; Majambu Mbikay; Michel Chrétien; Nabil G Seidah; Annik Prat
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.
Molecular and cellular biology 2006;26(1):354-61.
2005: Carly St Germain; Gilles Croissandeau; Janice Mayne; Jay M Baltz; Michel Chrétien; Majambu Mbikay
Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Molecular reproduction and development 2005;72(4):483-93.
2005: Philipp Stawowy; Heike Meyborg; Dietger Stibenz; Núbia Borges Pereira Stawowy; Mattias Roser; Usan Thanabalasingam; John P Veinot; Michel Chrétien; Nabil G Seidah; Eckart Fleck; Kristof Graf
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Circulation 2005;111(21):2820-7.
2005: Philipp Stawowy; Heike Kallisch; Núbia Borges Pereira Stawowy; Dietger Stibenz; John P Veinot; Michael Gräfe; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
Virchows Archiv : an international journal of pathology 2005;446(4):351-9.
2005: Eric Bergeron; Martin J Vincent; Louise Wickham; Josée Hamelin; Ajoy Basak; Stuart T Nichol; Michel Chrétien; Nabil G Seidah
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus.
Biochemical and biophysical research communications 2005;326(3):554-63.
2005: George N Tzimas; Eric Chevet; Sarah Jenna; Duc Thang Nguyên; Abdel-Majid Khatib; Victoria A Marcus; Yi Zhang; Michel Chrétien; Nabil G Seidah; Peter Metrakos
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.
BMC cancer 2005;5():149.
2004: Suzanne Benjannet; James A Cromlish; Karidia Diallo; Michel Chrétien; Nabil G Seidah
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Biochemical and biophysical research communications 2004;325(1):235-42.
2004: Suzanne Benjannet; David Rhainds; Rachid Essalmani; Janice Mayne; Louise Wickham; Weijun Jin; Marie-Claude Asselin; Josée Hamelin; Mathilde Varret; Delphine Allard; Mélanie Trillard; Marianne Abifadel; Angie Tebon; Alan D Attie; Daniel J Rader; catherine boileau; Louise Brissette; Michel Chrétien; Annik Prat; Nabil G Seidah
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
The Journal of biological chemistry 2004;279(47):48865-75.
2004: Philipp Stawowy; Heike Kallisch; Adam Kilimnik; Christian Margeta; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.
Biochemical and biophysical research communications 2004;321(3):531-8.
2004: Philipp Stawowy; Christian Margeta; Heike Kallisch; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase.
Cardiovascular research 2004;63(1):87-97.
2004: Philipp Stawowy; Heike Kallisch; John P Veinot; Adam Kilimnik; Wendy Prichett; Stephan Goetze; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.
Circulation 2004;109(6):770-6.
2003: Geraldine Siegfried; Ajoy Basak; James A Cromlish; Suzanne Benjannet; Jadwiga Marcinkiewicz; Michel Chrétien; Nabil G Seidah; Abdel-Majid Khatib
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
The Journal of clinical investigation 2003;111(11):1723-32.
2003: Geraldine Siegfried; Abdel-Majid Khatib; Suzanne Benjannet; Michel Chrétien; Nabil G Seidah
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
Cancer research 2003;63(7):1458-63.
2003: Philipp Stawowy; Kristof Graf; Stephan Goetze; Mattias Roser; Michel Chrétien; Nabil G Seidah; Eckart Fleck; Mieczyslaw Marcinkiewicz
Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.
Histochemistry and cell biology 2003;119(3):239-45.
2002: Majambu Mbikay; Marie-Laure Raffin-Sanson; Francine Sirois; Luaba Kalenga; Michel Chrétien; Nabil G Seidah
Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.
Brain research. Molecular brain research 2002;102(1-2):35-47.
2002: Gilles Croissandeau; Michel Chrétien; Majambu Mbikay
Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes.
The Biochemical journal 2002;364(Pt 3):739-46.
2002: Abdel-Majid Khatib; Geraldine Siegfried; Michel Chrétien; Peter Metrakos; Nabil G Seidah
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.
The American journal of pathology 2002;160(6):1921-35.
2002: Haidy Tadros; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(2):109-11.
2002: Gilles Croissandeau; Ajoy Basak; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.
Journal of cell science 2002;115(Pt 6):1203-11.
2002: Philipp Stawowy; Florian Blaschke; Adam Kilimnik; Stephan Goetze; Heike Kallisch; Michel Chrétien; Mieczyslaw Marcinkiewicz; Eckart Fleck; Kristof Graf
Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells.
Hypertension 2002;39(2 Pt 2):399-404.
2001: Abdel-Majid Khatib; Geraldine Siegfried; Annik Prat; J Luis; Michel Chrétien; Peter Metrakos; Nabil G Seidah
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.
The Journal of biological chemistry 2001;276(33):30686-93.
2001: Majambu Mbikay; Nabil G Seidah; Michel Chrétien
Neuroendocrine secretory protein 7B2: structure, expression and functions.
The Biochemical journal 2001;357(Pt 2):329-42.
2001: Suzanne Benjannet; A Elagoz; Louise Wickham; M Mamarbachi; JS Munzer; Ajoy Basak; Claude Lazure; James A Cromlish; Sangram S Sisodia; F Checler; Michel Chrétien; Nabil G Seidah
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
The Journal of biological chemistry 2001;276(14):10879-87.
2001: Philipp Stawowy; Jadwiga Marcinkiewicz; Kristof Graf; Nabil G Seidah; Michel Chrétien; E Fleck; Mieczyslaw Marcinkiewicz
Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(3):323-32.
2001: Ajoy Basak; M Zhong; JS Munzer; Michel Chrétien; Nabil G Seidah
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides.
The Biochemical journal 2001;353(Pt 3):537-45.
2001: Haidy Tadros; Michel Chrétien; Majambu Mbikay
The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary.
Journal of reproductive immunology 2001;49(2):133-52.
2000: C Rovère; J S Mort; Michel Chrétien; Nabil G Seidah
Cathepsin-B fusion proteins misroute secretory protein partners such as the proprotein convertase PC2-7B2 complex toward the lysosomal degradation pathways.
Biochemical and biophysical research communications 2000;276(2):594-9.
2000: Jean-Claude Lissitzky; José Luis; JS Munzer; Suzanne Benjannet; Fabrice Parat; Michel Chrétien; Jacques Marvaldi; Nabil G Seidah
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.
The Biochemical journal 2000;346 Pt 1():133-8.
2000: BB Touré; JS Munzer; Ajoy Basak; Suzanne Benjannet; J Rochemont; Claude Lazure; Michel Chrétien; Nabil G Seidah
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.
The Journal of biological chemistry 2000;275(4):2349-58.
1999: Nabil G Seidah; Michel Chrétien
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Brain research 1999;848(1-2):45-62.
1999: M Zhong; JS Munzer; Ajoy Basak; Suzanne Benjannet; SJ Mowla; jeff Keyser; Michel Chrétien; Nabil G Seidah
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.
The Journal of biological chemistry 1999;274(48):33913-20.
1999: Nabil G Seidah; Suzanne Benjannet; Josée Hamelin; Aida M Mamarbachi; Ajoy Basak; Jadwiga Marcinkiewicz; Majambu Mbikay; Michel Chrétien; Mieczyslaw Marcinkiewicz
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.
Annals of the New York Academy of Sciences 1999;885():57-74.
1999: Ajoy Basak; BB Touré; Claude Lazure; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Enzymic characterization in vitro of recombinant proprotein convertase PC4.
The Biochemical journal 1999;343 Pt 1():29-37.
1999: C Rovère; José Luis; Jean-Claude Lissitzky; Ajoy Basak; Jacques Marvaldi; Michel Chrétien; Nabil G Seidah
The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.
The Journal of biological chemistry 1999;274(18):12461-7.
1999: Nabil G Seidah; SJ Mowla; Josée Hamelin; Aida M Mamarbachi; Suzanne Benjannet; BB Touré; Ajoy Basak; JS Munzer; Jadwiga Marcinkiewicz; M Zhong; J C Barale; Claude Lazure; Richard A Murphy; Michel Chrétien; Mieczyslaw Marcinkiewicz
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1321-6.
1999: Ajoy Basak; S Cooper; A G Roberge; U K Banik; Michel Chrétien; Nabil G Seidah
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.
The Biochemical journal 1999;338 ( Pt 1)():107-13.
1999: Mieczyslaw Marcinkiewicz; Jadwiga Marcinkiewicz; A Chen; F Leclaire; Michel Chrétien; P Richardson
Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells.
The Journal of comparative neurology 1999;403(4):471-85.
1998: A Boudreault; Dany Gauthier; N Rondeau; D Savaria; Nabil G Seidah; Michel Chrétien; Claude Lazure
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells.
Protein expression and purification 1998;14(3):353-66.
1998: S E Girardin; Suzanne Benjannet; J C Barale; Michel Chrétien; Nabil G Seidah
The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells.
FEBS letters 1998;431(3):333-8.
1998: Suzanne Benjannet; Aida M Mamarbachi; Josée Hamelin; D Savaria; JS Munzer; Michel Chrétien; Nabil G Seidah
Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity.
FEBS letters 1998;428(1-2):37-42.
1998: Nabil G Seidah; R Day; Mieczyslaw Marcinkiewicz; Michel Chrétien
Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins.
Annals of the New York Academy of Sciences 1998;839():9-24.
1997: Suzanne Benjannet; D Savaria; Andrea Laslop; JS Munzer; Michel Chrétien; Mieczyslaw Marcinkiewicz; Nabil G Seidah
Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway.
The Journal of biological chemistry 1997;272(42):26210-8.
1997: Nabil G Seidah; Michel Chrétien
Eukaryotic protein processing: endoproteolysis of precursor proteins.
Current opinion in biotechnology 1997;8(5):602-7.
1997: J Lusson; Suzanne Benjannet; Josée Hamelin; D Savaria; Michel Chrétien; Nabil G Seidah
The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.
The Biochemical journal 1997;326 ( Pt 3)():737-44.
1997: JS Munzer; Ajoy Basak; M Zhong; Aida M Mamarbachi; Josée Hamelin; D Savaria; Claude Lazure; G N Hendy; Suzanne Benjannet; Michel Chrétien; Nabil G Seidah
In vitro characterization of the novel proprotein convertase PC7.
The Journal of biological chemistry 1997;272(32):19672-81.
1997: Majambu Mbikay; Haidy Tadros; N Ishida; Charles P Lerner; E De Lamirande; A Chen; Mohamed El-Alfy; Y Clermont; Nabil G Seidah; Michel Chrétien; C Gagnon; Elizabeth M Simpson
Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6842-6.
1997: Hooman F Farhadi; S Pareek; R Day; W Dong; Michel Chrétien; J J Bergeron; Nabil G Seidah; Richard A Murphy
Prohormone convertases in mouse submandibular gland: co-localization of furin and nerve growth factor.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(6):795-804.
1997: W Dong; B Seidel; M Marcinkiewicz; Michel Chrétien; Nabil G Seidah; Robert Day
Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):563-75.
1997: Majambu Mbikay; Francine Sirois; J Yao; Nabil G Seidah; Michel Chrétien
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
British journal of cancer 1997;75(10):1509-14.
1997: M Marcinkiewicz; T Nagao; R Day; Nabil G Seidah; Michel Chrétien; Massimo Avoli
Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression.
Neuroscience 1997;76(2):425-39.
1996: A Meyer; P Chrétien; G Massicotte; C Sargent; Michel Chrétien; Mieczyslaw Marcinkiewicz
Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus.
Brain research 1996;732(1-2):121-32.
1996: A Boudreault; V F Castellucci; Michel Chrétien; C Lazure
Identification, purification, and characterization of the molecular forms of Aplysia californica peptidylglycine alpha-amidating enzyme.
Journal of neurochemistry 1996;66(6):2596-605.
1996: Nabil G Seidah; Suzanne Benjannet; S Pareek; D Savaria; Josée Hamelin; B Goulet; J Laliberte; Claude Lazure; Michel Chrétien; R A Murphy
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
The Biochemical journal 1996;314 ( Pt 3)():951-60.
1996: F Vollenweider; Suzanne Benjannet; jeff Keyser; D Savaria; Claude Lazure; Gary Thomas; Michel Chrétien; Nabil G Seidah
Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.
The Biochemical journal 1996;314 ( Pt 2)():521-32.
1996: Nabil G Seidah; Suzanne Benjannet; S Pareek; Michel Chrétien; R A Murphy
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases.
FEBS letters 1996;379(3):247-50.
1996: Mieczyslaw Marcinkiewicz; Nabil G Seidah; Michel Chrétien
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues.
Acta neurobiologiae experimentalis 1996;56(1):287-98.
1995: Ajoy Basak; A Boudreault; A Chen; Michel Chrétien; Nabil G Seidah; Claude Lazure
Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(6):385-95.
1995: Ajoy Basak; C Schmidt; A A Ismail; Nabil G Seidah; Michel Chrétien; Claude Lazure
Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases.
International journal of peptide and protein research 1995;46(3-4):228-37.
1995: Majambu Mbikay; G Grondin; N Rondeau; Brian G Talbot; Michel Chrétien
A chimeric proinsulin-CD5 protein expressed in AtT-20 cells is directed to the cell surface via the constitutive pathway.
Experimental cell research 1995;220(1):79-91.
1995: Moise Bendayan; Daniela Malide; Ehud Ziv; E Levy; R Ben-Sasson; R Kalman; H Bar-On; Michel Chrétien; Nabil G Seidah
Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(8):771-84.
1995: Suzanne Benjannet; D Savaria; Michel Chrétien; Nabil G Seidah
7B2 is a specific intracellular binding protein of the prohormone convertase PC2.
Journal of neurochemistry 1995;64(5):2303-11.
1995: Suzanne Benjannet; J Lusson; Josée Hamelin; D Savaria; Michel Chrétien; Nabil G Seidah
Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex.
FEBS letters 1995;362(2):151-5.
1995: Michel Chrétien; Majambu Mbikay; L Gaspar; Nabil G Seidah
Proprotein convertases and the pathophysiology of human diseases: prospective considerations.
Proceedings of the Association of American Physicians 1995;107(1):47-66.
1995: Majambu Mbikay; Nabil G Seidah; Michel Chrétien; Elizabeth M Simpson
Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.
Genomics 1995;26(1):123-9.
1995: G Beaubien; M K Schäfer; E Weihe; W Dong; Michel Chrétien; Nabil G Seidah; R Day
The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates.
Cell and tissue research 1995;279(3):539-49.
1995: Daniela Malide; Nabil G Seidah; Michel Chrétien; Moise Bendayan
Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(1):11-9.
1994: Nabil G Seidah; J C Barale; Mieczyslaw Marcinkiewicz; M G Mattei; R Day; Michel Chrétien
The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.
DNA and cell biology 1994;13(12):1163-80.
1994: M Marcinkiewicz; D Ramla; Nabil G Seidah; Michel Chrétien
Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
Endocrinology 1994;135(4):1651-60.
1994: M Marcinkiewicz; P Touraine; Michel Chrétien
Pan-neuronal mRNA expression of the secretory polypeptide 7B2.
Neuroscience letters 1994;177(1-2):91-4.
1994: L Paquet; F Bergeron; A Boudreault; Nabil G Seidah; Michel Chrétien; Majambu Mbikay; Claude Lazure
The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.
The Journal of biological chemistry 1994;269(30):19279-85.
1994: N Ftouhi; R Day; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Gene organization of the mouse pro-hormone and pro-protein convertase PC1.
DNA and cell biology 1994;13(4):395-407.
1994: A Dupuy; Iris Lindberg; Y Zhou; Huda Akil; Claude Lazure; Michel Chrétien; Nabil G Seidah; R Day
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue.
FEBS letters 1994;337(1):60-5.
1994: Nabil G Seidah; Michel Chrétien
Pro-protein convertases of subtilisin/kexin family.
Methods in enzymology 1994;244():175-88.
1993: Suzanne Benjannet; N Rondeau; L Paquet; A Boudreault; Claude Lazure; Michel Chrétien; Nabil G Seidah
Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
The Biochemical journal 1993;294 ( Pt 3)():735-43.
1993: Nabil G Seidah; Robert Day; Michel Chrétien
The family of pro-hormone and pro-protein convertases.
Biochemical Society transactions 1993;21 ( Pt 3)(3):685-91.
1993: J Lusson; D Vieau; Josée Hamelin; R Day; Michel Chrétien; Nabil G Seidah
cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6691-5.
1993: M Marcinkiewicz; P Touraine; Majambu Mbikay; Michel Chrétien
Expression of neuroendocrine secretory protein 7B2 mRNA in the mouse and rat pituitary gland.
Neuroendocrinology 1993;58(1):86-93.
1993: F Jean; Ajoy Basak; N Rondeau; Suzanne Benjannet; Geoffrey N Hendy; Nabil G Seidah; Michel Chrétien; Claude Lazure
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.
The Biochemical journal 1993;292 ( Pt 3)():891-900.
1993: A Basak; X W Yuan; R Harris; Nabil G Seidah; Michel Chrétien
Synthesis of the segment (11-23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328-343) to high-molecular-mass kininogen.
Journal of chromatography 1993;615(2):251-64.
1993: M Marcinkiewicz; Robert Day; Nabil G Seidah; Michel Chrétien
Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4922-6.
1993: Ryno J Naudé; D Litthauer; Willem Oelofsen; Michel Chrétien; Claude Lazure
The production of the ostrich NH2-terminal POMC fragment requires cleavage at a unique signal peptidase site.
Peptides 1993;14(3):519-29.
1993: Ajoy Basak; A Boudreault; F Jean; Michel Chrétien; Claude Lazure
Radiolabeled biotinyl peptides as useful reagents for the study of proteolytic enzymes.
Analytical biochemistry 1993;209(2):306-14.
1992: Nabil G Seidah; H Fournier; Guy Boileau; Suzanne Benjannet; N Rondeau; Michel Chrétien
The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC.
FEBS letters 1992;310(3):235-9.
1992: A Basak; X W Yuan; Nabil G Seidah; Michel Chrétien; C Lazure
Affinity purification of proteinases by a combination of immobilized peptidyl aldehyde and semicarbazone.
Journal of chromatography 1992;581(1):17-29.
1992: Nabil G Seidah; R Day; J Hamelin; A Gaspar; M W Collard; Michel Chrétien
Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1559-70.
1992: Suzanne Benjannet; Timothy L Reudelhuber; C Mercure; N Rondeau; Michel Chrétien; Nabil G Seidah
Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.
The Journal of biological chemistry 1992;267(16):11417-23.
1992: Nabil G Seidah; Robert Day; Suzanne Benjannet; N Rondeau; A Boudreault; Timothy L Reudelhuber; M K Schafer; S J Watson; Michel Chrétien
The prohormone and proprotein processing enzymes PC1 and PC2: structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation.
NIDA research monograph 1992;126():132-50.
1991: L Paquet; N Rondeau; Nabil G Seidah; Claude Lazure; Michel Chrétien; Majambu Mbikay
Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2.
FEBS letters 1991;294(1-2):23-6.
1991: Claude Lazure; Suzanne Benjannet; Nabil G Seidah; Michel Chrétien
Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts.
International journal of peptide and protein research 1991;38(4):392-400.
1991: Nabil G Seidah; M G Mattei; L Gaspar; Suzanne Benjannet; Majambu Mbikay; Michel Chrétien
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Genomics 1991;11(1):103-7.
1991: S Nolet; Majambu Mbikay; Michel Chrétien
Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human.
Biochimica et biophysica acta 1991;1089(2):247-9.
1991: Suzanne Benjannet; N Rondeau; Robert Day; Michel Chrétien; Nabil G Seidah
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3564-8.
1991: F Jean; Ajoy Basak; Michel Chrétien; Claude Lazure
Detection of endopeptidase activity and analysis of cleavage specificity using a radiometric solid-phase enzymatic assay.
Analytical biochemistry 1991;194(2):399-406.
1991: N Sawyer; N Rondeau; Michel Chrétien; Nabil G Seidah
Expression and sorting of rat plasma kallikrein in POMC-producing AtT-20 cells.
DNA and cell biology 1991;10(4):259-69.
1991: S Nolet; D St-Louis; Majambu Mbikay; Michel Chrétien
Rapid evolution of prostatic protein PSP94 suggested by sequence divergence between rhesus monkey and human cDNAs.
Genomics 1991;9(4):775-7.
1991: G Beaubien; I Rosinski-Chupin; M G Mattei; Majambu Mbikay; Michel Chrétien; Nabil G Seidah
Gene structure and chromosomal localization of plasma kallikrein.
Biochemistry 1991;30(6):1628-35.
1991: L Paquet; Claude Lazure; Nabil G Seidah; Michel Chrétien; Majambu Mbikay
The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.
Biochemical and biophysical research communications 1991;174(1):156-62.
1991: Nabil G Seidah; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; L Gaspar; G Beaubien; M G Mattei; Claude Lazure; Majambu Mbikay; Michel Chrétien
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.
Molecular endocrinology (Baltimore, Md.) 1991;5(1):111-22.
1991: Nabil G Seidah; R Day; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; Michel Chrétien
Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases.
Enzyme 1991;45(5-6):271-84.
1990: Nabil G Seidah; L Gaspar; P Mion; Mieczyslaw Marcinkiewicz; Majambu Mbikay; Michel Chrétien
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
DNA and cell biology 1990;9(10):789.
1990: Nabil G Seidah; N Sawyer; Josée Hamelin; P Mion; G Beaubien; L Brachpapa; J Rochemont; Majambu Mbikay; Michel Chrétien
Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species.
DNA and cell biology 1990;9(10):737-48.
1990: Ajoy Basak; Y T Gong; J A Cromlish; J A Paquin; F Jean; Nabil G Seidah; Claude Lazure; Michel Chrétien
Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases.
International journal of peptide and protein research 1990;36(1):7-17.
1990: Nabil G Seidah; L Gaspar; P Mion; Mieczyslaw Marcinkiewicz; Majambu Mbikay; Michel Chrétien
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
DNA and cell biology 1990;9(6):415-24.
1990: Claude Lazure; L Paquet; D Litthauer; Ryno J Naudé; Willem Oelofsen; Michel Chrétien
The ostrich pituitary contains a major peptide homologous to mammalian chromogranin A(1-76).
Peptides 1990;11(1):79-87.
1990: P Touraine; Majambu Mbikay; N G Seidah; Michel Chrétien
[Prader-Willi-Labhart syndrome: relations with the hypothalamus and chromosome 15].
Annales d'endocrinologie 1990;51(5-6):202-8.
1989: J Paquin; Suzanne Benjannet; N Sawyer; Claude Lazure; Michel Chrétien; Nabil G Seidah
Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay.
Biochimica et biophysica acta 1989;999(2):103-10.
1989: Puttaswamy Manjunath; Yves L Marcel; J Uma; Nabil G Seidah; Michel Chrétien; A Chapdelaine
Apolipoprotein A-I binds to a family of bovine seminal plasma proteins.
The Journal of biological chemistry 1989;264(28):16853-7.
1989: N G Seidah; R Ladenheim; Majambu Mbikay; Josée Hamelin; G Lutfalla; F Rougeon; Claude Lazure; Michel Chrétien
The cDNA structure of rat plasma kallikrein.
DNA (Mary Ann Liebert, Inc.) 1989;8(8):563-74.
1989: F Gilbert; J S Chan; Suzanne Benjannet; Nabil G Seidah; P Nadeau; André Duranceau; E Lafontaine; R Beaulieu; Michel Chrétien
Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(5):285-91.
1989: L Gaspar; F Gilbert; J S Chan; Nabil G Seidah; Michel Chrétien
Urinary levels of immunoreactive NH2-terminal of pro-opiomelanocortin in patients with malignant pulmonary disease.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(4):241-6.
1989: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Peptides related to the N-terminus of pro-opiomelanocortin in the human adrenal medulla.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(2):90-8.
1989: Claude Lazure; H S Saayman; Ryno J Naudé; Willem Oelofsen; Michel Chrétien
Ostrich MSEL-neurophysin belongs to the class of two-domain "big" neurophysin as indicated by complete amino acid sequence of the neurophysin/copeptin.
International journal of peptide and protein research 1989;33(1):46-58.
1989: Majambu Mbikay; S G Grant; F Sirois; H Tadros; J Skowronski; C Lazure; Nabil G Seidah; Douglas Hanahan; Michel Chrétien
cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice.
International journal of peptide and protein research 1989;33(1):39-45.
1988: Mieczyslaw Marcinkiewicz; R Fischer-Colbrie; Jean-Pierre Falgueyret; Suzanne Benjannet; Nabil G Seidah; Claude Lazure; H Winkler; Michel Chrétien
Two-dimensional immunoblotting analysis and immunocytochemical localization of the secretory polypeptide 7B2 in adrenal medulla.
Neuroscience letters 1988;95(1-3):81-7.
1988: C Lazure; Huy Ong; Normand McNicoll; P Netchitailo; Michel Chrétien; André De Léan; H Vaudry
The amino acid sequences of frog heart atrial natriuretic-like peptide and mammalian ANF are closely related.
FEBS letters 1988;238(2):300-6.
1988: K M Metters; J Rossier; J Paquin; Michel Chrétien; Nabil G Seidah
Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein.
The Journal of biological chemistry 1988;263(25):12543-53.
1988: Mieczyslaw Marcinkiewicz; Suzanne Benjannet; Jean-Pierre Falgueyret; Nabil G Seidah; W Schürch; M Verdy; M Cantin; Michel Chrétien
Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma.
Endocrinology 1988;123(2):866-73.
1988: Suzanne Benjannet; Mieczyslaw Marcinkiewicz; Jean-Pierre Falgueyret; D E Johnson; Nabil G Seidah; Michel Chrétien
Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors.
Endocrinology 1988;123(2):874-84.
1988: A Brar; Majambu Mbikay; F Sirois; S Fournier; Nabil G Seidah; Michel Chrétien
Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate.
Journal of andrology 1988;9(4):253-60.
1987: Claude Lazure; H S Saayman; Ryno J Naudé; Willem Oelofsen; Michel Chrétien
Complete amino acid sequence of a VLDV-type neurophysin from ostrich differs markedly from known mammalian neurophysins.
International journal of peptide and protein research 1987;30(5):634-45.
1987: Jean-Pierre Falgueyret; Mieczyslaw Marcinkiewicz; Suzanne Benjannet; M Cantin; Nabil G Seidah; Michel Chrétien
Immunocytochemical localization of a novel pituitary polypeptide "7B2" in the gastro-intestinal tract of the rat.
Cell and tissue research 1987;249(3):707-9.
1987: F Gilbert; W Walop; J S Chan; Suzanne Benjannet; Nabil G Seidah; W O Spitzer; Michel Chrétien
The role of the NH2-terminal portion of pro-opiomelanocortin as a biomarker for human lung cancer.
Clinical and investigative medicine. Médecine clinique et experimentale 1987;10(5):372-6.
1987: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid.
The Journal of clinical endocrinology and metabolism 1987;65(1):198-202.
1987: Nabil G Seidah; Geoffrey N Hendy; Josée Hamelin; J Paquin; Claude Lazure; K M Metters; J Rossier; Michel Chrétien
Chromogranin A can act as a reversible processing enzyme inhibitor. Evidence from the inhibition of the IRCM-serine protease 1 cleavage of pro-enkephalin and ACTH at pairs of basic amino acids.
FEBS letters 1987;211(2):144-50.
1987: J A Cromlish; N G Seidah; M Marcinkiewicz; Josée Hamelin; D A Johnson; Michel Chrétien
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
The Journal of biological chemistry 1987;262(3):1363-73.
1985: W H Berrettini; J I Nurnberger; J S Chan; G P Chrousos; L Gaspar; P W Gold; Nabil G Seidah; S Simmons-Alling; L R Goldin; Michel Chrétien
Pro-opiomelanocortin-related peptides in cerebrospinal fluid: a study of manic-depressive disorder.
Psychiatry research 1985;16(4):287-302.
1985: Suzanne Benjannet; R Leduc; Claude Lazure; Nabil G Seidah; Mieczyslaw Marcinkiewicz; Michel Chrétien
GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.
Biochemical and biophysical research communications 1985;126(1):602-9.
1985: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Characterization of peptides derived from pro-opiomelanocortin in the biological fluids of a patient with Nelson's syndrome.
Clinical and investigative medicine. Médecine clinique et experimentale 1985;8(2):167-75.
1984: L Gaspar; J S Chan; Nabil G Seidah; Michel Chrétien
Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney.
The Journal of clinical endocrinology and metabolism 1984;59(4):614-21.
1984: D Pélaprat; N G Seidah; R A Sikstrom; P Lambelin; Josée Hamelin; Claude Lazure; J A Cromlish; Michel Chrétien
Subcellular fractionation of pituitary neurointermediate lobes: revelation of various basic proteases.
Endocrinology 1984;115(2):581-90.
1984: J S Chan; L Gaspar; H Iguchi; Nabil G Seidah; N Ling; Michel Chrétien
Synergistical effects of ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on the release of pro-opiomelanocortin (POMC) related peptides by pituitary adenoma of a patient with Nelson's syndrome in vitro.
Clinical and investigative medicine. Médecine clinique et experimentale 1984;7(4):205-8.
1983: Nabil G Seidah; K L Hsi; G De Serres; J Rochemont; Josée Hamelin; T Antakly; M Cantin; Michel Chrétien
Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus.
Archives of biochemistry and biophysics 1983;225(2):525-34.
1983: Nabil G Seidah; D Pélaprat; J Rochemont; P Lambelin; M Dennis; J S Chan; Josée Hamelin; Claude Lazure; Michel Chrétien
Enzymatic maturation of pro-opiomelanocortin by anterior pituitary granules. Methodological approach leading to definite characterization of cleavage sites by means of high-performance liquid chromatography and microsequencing.
Journal of chromatography 1983;266():213-24.
1983: Guy Boileau; F Gossard; Nabil G Seidah; Michel Chrétien
Cell-free synthesis of porcine proopiomelanocortin: two distinct primary translation products.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1983;61(6):333-9.
1982: K L Hsi; Nabil G Seidah; G De Serres; Michel Chrétien
Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.
FEBS letters 1982;147(2):261-6.
1982: Guy Boileau; N Larivière; K L Hsi; Nabil G Seidah; Michel Chrétien
Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide.
Biochemistry 1982;21(21):5341-6.
1982: Nabil G Seidah; N Larivière; Guy Boileau; F Gossard; K L Hsi; C L Lu; Michel Chrétien
Gene expression of peptides: the pro-opiomelanocortin model.
Advances in biochemical psychopharmacology 1982;33():19-26.
1981: K L Hsi; Nabil G Seidah; C L Lu; Michel Chrétien
Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands.
Biochemical and biophysical research communications 1981;103(4):1329-35.
1981: Nabil G Seidah; J Rochemont; Josée Hamelin; Suzanne Benjannet; Michel Chrétien
The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation.
Biochemical and biophysical research communications 1981;102(2):710-6.
1981: Nabil G Seidah; J Rochemont; Josée Hamelin; M Lis; Michel Chrétien
Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity.
The Journal of biological chemistry 1981;256(15):7977-84.
1980: N Larivière; Nabil G Seidah; G De Serres; J Rochemont; Michel Chrétien
Two glycosylation sites on the N-terminal segment of porcine pars distalis pro-opiomelanocortin.
FEBS letters 1980;122(2):279-82.
1980: Philippe Crine; Nabil G Seidah; R Routhier; F Gossard; Michel Chrétien
Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides.
European journal of biochemistry / FEBS 1980;110(2):387-96.
1980: Michel Chrétien; F Gossard; Philippe Crine; C Gianoulakis; Nabil G Seidah
New perspectives in neuropeptides. Biosynthesis from large precursors. The pro-opio-melanocortin model in the pars intermedia.
Acta psychiatrica Belgica 1980;80(5):699-713.
1980: Nabil G Seidah; Suzanne Benjannet; R Routhier; G De Serres; J Rochemont; M Lis; Michel Chrétien
Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence.
Biochemical and biophysical research communications 1980;95(4):1417-24.
1980: C Gianoulakis; Nabil G Seidah; R Routhier; Michel Chrétien
Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis. Further characterization.
International journal of peptide and protein research 1980;16(2):97-105.
1980: S Benjannet; Nabil G Seidah; R Routhier; Michel Chrétien
A novel human pituitary peptide containing the gamma-MSH sequence.
Nature 1980;285(5764):415-6.
1980: Nabil G Seidah; R Routhier; S Benjannet; N Larivière; F Gossard; Michel Chrétien
Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments.
Journal of chromatography 1980;193(2):291-9.
1980: F Gossard; Nabil G Seidah; Philippe Crine; R Routhier; Michel Chrétien
Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia.
Biochemical and biophysical research communications 1980;92(3):1042-51.
1980: Michel Chrétien; F Gossard; Philippe Crine; C Gianoulakis; Nabil G Seidah
Structure and maturation process of pro-opiomelanocortin: a model for other neuropeptides.
Advances in biochemical psychopharmacology 1980;22():153-66.
1980: Nabil G Seidah; F Gossard; Philippe Crine; C Gianoulakis; R Routhier; Michel Chrétien
Chemical characterization of rat alpha MSH/beta-endorphin precursor from pars intermedia.
Annals of the New York Academy of Sciences 1980;343():443-6.