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Premkumar Christadoss

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Ruksana Huda; Erdem Tüzün; Premkumar Christadoss
Complement C2 siRNA mediated therapy of myasthenia gravis in mice.
Weifan Yin; Windy Allman; Premkumar Christadoss; Jing Li; Yi Li; Song Ouyang; Huan Yang
The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis.
Bo Wu; Elzbieta Goluszko; Ruksana Huda; Erdem Tüzün; Premkumar Christadoss
Experimental autoimmune myasthenia gravis in the mouse.

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All Publications

2013: Ruksana Huda; Erdem Tüzün; Premkumar Christadoss
Complement C2 siRNA mediated therapy of myasthenia gravis in mice.
Journal of autoimmunity 2013;42():94-104.
2013: Weifan Yin; Windy Allman; Premkumar Christadoss; Jing Li; Yi Li; Song Ouyang; Huan Yang
The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis.
Journal of neuroimmunology 2013;256(1-2):49-54.
2013: Bo Wu; Elzbieta Goluszko; Ruksana Huda; Erdem Tüzün; Premkumar Christadoss
Experimental autoimmune myasthenia gravis in the mouse.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2013;Chapter 15():Unit 15.8..
2012: Erdem Tüzün; Canan Ulusoy; Huan Yang; Windy Allman; Premkumar Christadoss
Novel animal models of acetylcholine receptor antibody-related myasthenia gravis.
Annals of the New York Academy of Sciences 2012;1274():133-9.
2012: Windy Allman; Jing Li; Huibin Qi; Shamsher S Saini; Erdem Tuzun; Premkumar Christadoss
CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis.
Journal of neuroimmunology 2012;249(1-2):1-7.
2012: Xiaorong Wu; Tianlin Xiao; Windy Allman; Jing Li; Huibin Qi; Shamsher S Saini; Erdem Tuzun; Premkumar Christadoss
Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunization.
Muscle & nerve 2012;45(2):209-16.
2011: Bo Wu; Elzbieta Goluszko; Ruksana Huda; Erdem Tüzün; Premkumar Christadoss
Experimental autoimmune myasthenia gravis in the mouse.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2011;Chapter 15():Unit 15.23.
2011: Erdem Tüzün; Ruksana Huda; Premkumar Christadoss
Complement and cytokine based therapeutic strategies in myasthenia gravis.
Journal of autoimmunity 2011;37(2):136-43.
2011: Huibin Qi; Jing Li; Windy Allman; Shamsher S Saini; Erdem Tüzün; Xiaorong Wu; D Estes; Premkumar Christadoss
Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis.
Journal of neuroimmunology 2011;234(1-2):165-7.
2011: Windy Allman; Shamsher S Saini; Erdem Tuzun; Premkumar Christadoss
Characterization of peripheral blood acetylcholine receptor-binding B cells in experimental myasthenia gravis.
Cellular immunology 2011;271(2):292-8.
2010: Huan Yang; Yong Zhang; Minghua Wu; Jing Li; Wenbin Zhou; Guiyuan Li; Xiaoling Li; BO XIAO; Premkumar Christadoss
Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2010;59(3):197-205.
2009: Jing Li; Huibin Qi; Erdem Tüzün; Windy Allman; Vuslat Yilmaz; Shamsher Saini; Feza Deymeer; Güher Saruhan-Direskeneli; Premkumar Christadoss
Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis.
Journal of neuroimmunology 2009;208(1-2):40-5.
2009: Yong Zhang; Huan Yang; BO XIAO; Minghua Wu; Wenbing Zhou; Jing Li; Guiyuan Li; Premkumar Christadoss
Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis.
Molecular immunology 2009;46(4):657-67.
2008: Huibin Qi; Erdem Tüzün; Windy Allman; Shamsher Saini; Zurina R Penabad; Silvia Pierangeli; Premkumar Christadoss
C5a is not involved in experimental autoimmune myasthenia gravis pathogenesis.
Journal of neuroimmunology 2008;196(1-2):101-6.
2008: Jing Li; Erdem Tüzün; Xiong Rong Wu; Hui Bin Qi; Windy Allman; Shamsher Saini; Premkumar Christadoss
Inhibitory IgG receptor FcgammaRIIB fails to inhibit experimental autoimmune myasthenia gravis pathogenesis.
Journal of neuroimmunology 2008;194(1-2):44-53.
2008: Erdem Tüzün; Jing Li; Shamsher Saini; Huan Yang; Premkumar Christadoss
Targeting classical complement pathway to treat complement mediated autoimmune diseases.
Advances in experimental medicine and biology 2008;632():265-72.
2008: Premkumar Christadoss; Erdem Tüzün; Jing Li; Shamsher Saini; Huan Yang
Classical complement pathway in experimental autoimmune myasthenia gravis pathogenesis.
Annals of the New York Academy of Sciences 2008;1132():210-9.
2007: Huan Yang; bo wu; Erdem Tüzün; Shamsher Saini; Jing Li; Windy Allman; Stephen Higgs; Tian Lin Xiao; Premkumar Christadoss
A new mouse model of autoimmune ocular myasthenia gravis.
Investigative ophthalmology & visual science 2007;48(11):5101-11.
2007: Erdem Tüzün; Jing Li; Shamsher Saini; Huan Yang; Premkumar Christadoss
Pros and cons of treating murine myasthenia gravis with anti-C1q antibody.
Journal of neuroimmunology 2007;182(1-2):167-76.
2006: Erdem Tüzün; Shamsher Saini; B Paul Morgan; Premkumar Christadoss
Complement regulator CD59 deficiency fails to augment susceptibility to actively induced experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2006;181(1-2):29-33.
2006: Zeynep Aydin-Ozemir; Erdem Tüzün; Betül Baykan; Gülsen Akman-Demir; Nese Ozbey; Candan Gürses; Premkumar Christadoss; Ayşen Gökyiğit
Autoimmune thyroid encephalopathy presenting with epilepsia partialis continua.
Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS) 2006;37(3):204-9.
2006: Erdem Tüzün; Jing Li; Nanchaya Wanasen; Lynn Soong; Premkumar Christadoss
Immunization of mice with T cell-dependent antigens promotes IL-6 and TNF-alpha production in muscle cells.
Cytokine 2006;35(1-2):100-6.
2006: Erdem Tüzün; Shamsher Saini; Huan Yang; Dhivyaa Alagappan; Stephen Higgs; Premkumar Christadoss
Genetic evidence for the involvement of Fcgamma receptor III in experimental autoimmune myasthenia gravis pathogenesis.
Journal of neuroimmunology 2006;174(1-2):157-67.
2006: Erdem Tüzün; Shamsher Saini; Sidharth Ghosh; Julie Rowin; Matthew N Meriggioli; Premkumar Christadoss
Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis.
Neuromuscular disorders : NMD 2006;16(2):137-43.
2005: Ruolan Liu; Antonio La Cava; Xue-Feng Bai; Youngheun Jee; Mary Price; Denise I Campagnolo; Premkumar Christadoss; Timothy L Vollmer; Luc Van Kaer; Fu-Dong Shi
Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7898-904.
2005: Shamsher Saini; Erdem Tüzün; Premkumar Christadoss
The cDNA of mouse skeletal muscle transcribe for both isoforms 1 and 2 of acetylcholine receptor alpha subunit.
Journal of neuroimmunology 2005;169(1-2):177-9.
2005: Huan Yang; Erdem Tüzün; Dhivyaa Alagappan; Xiang Yu; Benjamin G Scott; Alexander Ischenko; Premkumar Christadoss
IL-1 receptor antagonist-mediated therapeutic effect in murine myasthenia gravis is associated with suppressed serum proinflammatory cytokines, C3, and anti-acetylcholine receptor IgG1.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):2018-25.
2005: Evangelos Karras; Huan Yang; Peggy Lymberi; Premkumar Christadoss
Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice.
Journal of autoimmunity 2005;24(4):291-6.
2005: Sandrine Poëa-Guyon; Premkumar Christadoss; Rozen Le Panse; Thierry Guyon; Marc H De Baets; Abdelilah Wakkach; Jocelyne Bidault; Socrates J Tzartos; Sonia Berrih-Aknin
Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):5941-9.
2005: Erdem Tüzün; Matthew N Meriggioli; Julie Rowin; Huan Yang; Premkumar Christadoss
Myasthenia gravis patients with low plasma IL-6 and IFN-gamma benefit from etanercept treatment.
Journal of autoimmunity 2005;24(3):261-8.
2005: Huan Yang; Mrinalini Kala; Benjamin G Scott; Elzbieta Goluszko; Harold A Chapman; Premkumar Christadoss
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1729-37.
2004: Julie Rowin; Matthew N Meriggioli; Erdem Tüzün; Sue Leurgans; Premkumar Christadoss
Etanercept treatment in corticosteroid-dependent myasthenia gravis.
Neurology 2004;63(12):2390-2.
2004: Benjamin G Scott; Huan Yang; Erdem Tüzün; Chen Dong; Richard A Flavell; Premkumar Christadoss
ICOS is essential for the development of experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2004;153(1-2):16-25.
2004: Erdem Tüzün; Benjamin G Scott; Huan Yang; bo wu; Elzbieta Goluszko; Michelle Guigneaux; Stephen Higgs; Premkumar Christadoss
Circulating immune complexes augment severity of antibody-mediated myasthenia gravis in hypogammaglobulinemic RIIIS/J mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5743-52.
2003: Erdem Tüzün; Benjamin G Scott; Elzbieta Goluszko; Stephen Higgs; Premkumar Christadoss
Genetic evidence for involvement of classical complement pathway in induction of experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3847-54.
2003: Huan Yang; Elzbieta Goluszko; Chella S David; David K Okita; Bianca M Conti-Fine; Teh-Sheng Chan; Mathilde A Poussin; Premkumar Christadoss
Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors.
Annals of the New York Academy of Sciences 2003;998():375-8.
2003: Caishu Deng; Bo Wu; Huan Yang; Rehana Z Hussain; Amy E Lovett-Racke; Premkumar Christadoss; Michael K Racke
Decreased expression of Src homology 2 domain-containing protein tyrosine phosphatase 1 reduces T cell activation threshold but not the severity of experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2003;138(1-2):76-82.
2003: Mathilde A Poussin; Erdem Tüzün; Elzbieta Goluszko; Benjamin G Scott; Huan Yang; Juan U Franco; Premkumar Christadoss
B7-1 costimulatory molecule is critical for the development of experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4389-96.
2003: Mathilde A Poussin; Claudette L Fuller; Elzbieta Goluszko; Victor E Reyes; Vivian L Braciale; Premkumar Christadoss
Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-gamma release by acetylcholine receptor-specific T cells.
Journal of neuroimmunology 2003;134(1-2):104-10.
2002: Caishu Deng; Elzbieta Goluszko; Erdem Tüzün; Huan Yang; Premkumar Christadoss
Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):1077-83.
2002: Mathilde A Poussin; Elzbieta Goluszko; Juan U Franco; Premkumar Christadoss
Role of IL-5 during primary and secondary immune response to acetylcholine receptor.
Journal of neuroimmunology 2002;125(1-2):51-8.
2002: Huan Yang; Elzbieta Goluszko; Chella S David; David K Okita; Bianca M Conti-Fine; Teh-Sheng Chan; Mathilde A Poussin; Premkumar Christadoss
Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice.
The Journal of clinical investigation 2002;109(8):1111-20.
2002: Premkumar Christadoss; Elzbieta Goluszko
Treatment of experimental autoimmune myasthenia gravis with recombinant human tumor necrosis factor receptor Fc protein.
Journal of neuroimmunology 2002;122(1-2):186-90.
2002: Elzbieta Goluszko; Caishu Deng; Mathilde A Poussin; Premkumar Christadoss
Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2002;122(1-2):85-93.
2001: Mathilde A Poussin; Elzbieta Goluszko; Chella S David; Juan U Franco; Premkumar Christadoss
HLA-DQ6 transgenic mice resistance to experimental autoimmune myasthenia gravis is linked to reduced acetylcholine receptor-specific IFN-gamma, IL-2 and IL-10 production.
Journal of autoimmunity 2001;17(3):175-80.
2001: bo wu; Elzbieta Goluszko; Premkumar Christadoss
Experimental autoimmune myasthenia gravis in the mouse.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 15():Unit 15.8.
2001: Caishu Deng; Elzbieta Goluszko; Premkumar Christadoss
Fas/Fas ligand pathway, apoptosis, and clonal anergy involved in systemic acetylcholine receptor T cell epitope tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3458-67.
2001: Elzbieta Goluszko; Peter Hjelmstrom; Caishu Deng; Mathilde A Poussin; Nancy H Ruddle; Premkumar Christadoss
Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2001;113(1):109-18.
2000: Mathilde A Poussin; Elzbieta Goluszko; Thomas K Hughes; S I Duchicella; Premkumar Christadoss
Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associated with reduced B cells and serum cytotoxicity on mouse cell line expressing AChR.
Journal of neuroimmunology 2000;111(1-2):152-60.
2000: Premkumar Christadoss; Mathilde A Poussin; Caishu Deng
Animal models of myasthenia gravis.
Clinical immunology (Orlando, Fla.) 2000;94(2):75-87.
1998: V Dedhia; Elzbieta Goluszko; bo wu; Caishu Deng; Premkumar Christadoss
The effect of B cell deficiency on the immune response to acetylcholine receptor and the development of experimental autoimmune myasthenia gravis.
Clinical immunology and immunopathology 1998;87(3):266-75.
1997: bo wu; Caishu Deng; Elzbieta Goluszko; Premkumar Christadoss
Tolerance to a dominant T cell epitope in the acetylcholine receptor molecule induces epitope spread and suppresses murine myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):3016-23.
1997: R Kaul; bo wu; Elzbieta Goluszko; Caishu Deng; V Dedhia; G H Nabozny; Chella S David; I J Rimm; Mohan Shenoy; T M Haqqi; Premkumar Christadoss
Experimental autoimmune myasthenia gravis in B10.BV8S2 transgenic mice: preferential usage of TCRAV1 gene by lymphocytes responding to acetylcholine receptor.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):6006-12.
1996: Caishu Deng; Elzbieta Goluszko; Samuel Baron; bo wu; Premkumar Christadoss
IFN-alpha therapy is effective in suppressing the clinical experimental myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5675-82.
1995: M Shenoy; Samuel Baron; bo wu; Elzbieta Goluszko; Premkumar Christadoss
IFN-alpha treatment suppresses the development of experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6203-8.
1995: bo wu; M Shenoy; Elzbieta Goluszko; R Kaul; Premkumar Christadoss
TCR gene usage in experimental autoimmune myasthenia gravis pathogenesis. Usage of multiple TCRBV genes in the H-2b strains.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3603-10.
1995: R Kaul; A Sharma; J R Lisse; Premkumar Christadoss
Human recombinant IL-2 augments immunoglobulin and induces rheumatoid factor production by rheumatoid arthritis lymphocytes engrafted into severe combined immunodeficient mice.
Clinical immunology and immunopathology 1995;74(3):271-82.
1995: Premkumar Christadoss; R Kaul; M Shenoy; Elzbieta Goluszko
Establishment of a mouse model of myasthenia gravis which mimics human myasthenia gravis pathogenesis for immune intervention.
Advances in experimental medicine and biology 1995;383():195-9.
1994: M Shenoy; R Kaul; Elzbieta Goluszko; Chella S David; Premkumar Christadoss
Effect of MHC class I and CD8 cell deficiency on experimental autoimmune myasthenia gravis pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5330-5.
1994: M Shenoy; Elzbieta Goluszko; Premkumar Christadoss
The pathogenic role of acetylcholine receptor alpha chain epitope within alpha 146-162 in the development of experimental autoimmune myasthenia gravis in C57BL6 mice.
Clinical immunology and immunopathology 1994;73(3):338-43.
1994: R Kaul; M Shenoy; Elzbieta Goluszko; Premkumar Christadoss
Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):3152-7.
1994: Premkumar Christadoss; M Shenoy; M Oshima; M Z Atassi
Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance.
Advances in experimental medicine and biology 1994;347():65-75.
1994: bo wu; M Shenoy; Premkumar Christadoss
T cell receptor gene regulation of experimental autoimmune myasthenia gravis.
Advances in neuroimmunology 1994;4(4):433-45.
1994: R Kaul; M Shenoy; Premkumar Christadoss
The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis.
Advances in neuroimmunology 1994;4(4):387-402.
1993: M Shenoy; Chella S David; M Oshima; M Z Atassi; Premkumar Christadoss
Molecular immunopathogenesis of myasthenia gravis using MHC class II mutant and transgenic mice.
Annals of the New York Academy of Sciences 1993;681():329-31.
1993: M Shenoy; Premkumar Christadoss
Induction of experimental autoimmune myasthenia gravis with acetylcholine receptors using a nonionic block copolymer as adjuvant.
Immunological investigations 1993;22(4):267-82.
1993: M Shenoy; M Oshima; M Z Atassi; Premkumar Christadoss
Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor.
Clinical immunology and immunopathology 1993;66(3):230-8.
1992: Premkumar Christadoss; M Shenoy
Molecular immunopathogenesis of experimental autoimmune myasthenia gravis.
Regional immunology 1992;4(5):314-20.
1992: M Shenoy; B MacPherson; Premkumar Christadoss
Suramin inhibits the mixed lymphocyte reaction by suppressing lymphokine production.
Journal of clinical immunology 1992;12(2):122-9.
1992: Premkumar Christadoss; Chella S David; S Keve
I-A alpha k transgene pairs with I-A beta b gene and protects C57BL10 mice from developing autoimmune myasthenia gravis.
Clinical immunology and immunopathology 1992;62(2):235-9.
1991: Premkumar Christadoss; R Henderson; S Keve
Daunomycin treatment prevents clinical expression of experimental autoimmune myasthenia gravis.
Clinical immunology and immunopathology 1991;59(2):246-55.
1990: Premkumar Christadoss; Chella S David; M Shenoy; S Keve
Ek alpha transgene in B10 mice suppresses the development of myasthenia gravis.
Immunogenetics 1990;31(4):241-4.
1989: Premkumar Christadoss
Immunogenetics of experimental autoimmune myasthenia gravis.
Critical reviews in immunology 1989;9(4):247-78.
1986: Premkumar Christadoss; J M Lindstrom; N Talal; C R Duvic; A Kalantri; M Shenoy
Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(6):1845-9.
1985: Premkumar Christadoss; J M Lindstrom; R W Melvold; N Talal
Mutation at I-A beta chain prevents experimental autoimmune myasthenia gravis.
Immunogenetics 1985;21(1):33-8.