Philipp Christen

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Sharma Sandeep K; Goloubinoff Pierre; Christen Philipp
Heavy metal ions are potent inhibitors of protein folding.
Vacca Rosa A; Giannattasio Sergio; Capitani Guido; Marra Ersilia; Christen Philipp
Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.
Siegenthaler Rahel K; Christen Philipp
Tuning of DnaK chaperone action by nonnative protein sensor DnaJ and thermosensor GrpE.

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2008: Sharma Sandeep K; Goloubinoff Pierre; Christen Philipp
Heavy metal ions are potent inhibitors of protein folding.
Biochemical and biophysical research communications 2008;372(2):341-5.
2008: Vacca Rosa A; Giannattasio Sergio; Capitani Guido; Marra Ersilia; Christen Philipp
Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.
BMC biochemistry 2008;9():17.
2006: Siegenthaler Rahel K; Christen Philipp
Tuning of DnaK chaperone action by nonnative protein sensor DnaJ and thermosensor GrpE.
The Journal of biological chemistry 2006;281(45):34448-56.
2005: Grimshaw John P A; Siegenthaler Rahel K; Züger Sara; Schönfeld Hans-Joachim; Z'graggen Birgit Roth; Christen Philipp
The heat-sensitive Escherichia coli grpE280 phenotype: impaired interaction of GrpE(G122D) with DnaK.
Journal of molecular biology 2005;353(4):888-96.
2005: Siegenthaler Rahel K; Christen Philipp
The importance of having thermosensor control in the DnaK chaperone system.
The Journal of biological chemistry 2005;280(15):14395-401.
2004: Fernandez Francisco J; Vega M Cristina; Lehmann Frank; Sandmeier Erika; Gehring Heinz; Christen Philipp; Wilmanns Matthias
Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase.
The Journal of biological chemistry 2004;279(20):21478-88.
2004: Han Wanjiang; Christen Philipp
cis-Effect of DnaJ on DnaK in ternary complexes with chimeric DnaK/DnaJ-binding peptides.
FEBS letters 2004;563(1-3):146-50.
2004: Siegenthaler Rahel K; Grimshaw John P A; Christen Philipp
Immediate response of the DnaK molecular chaperone system to heat shock.
FEBS letters 2004;562(1-3):105-10.
2004: Koller Michael F; Mohajeri M Hasan; Huber Michael; Wollmer M Axel; Roth Z'graggen Birgit V; Sandmeier Erika; Moritz Eva; Tracy Jay; Nitsch Roger M; Christen Philipp
Active immunization of mice with an Abeta-Hsp70 vaccine.
Neuro-degenerative diseases 2004;1(1):20-8.
2003: Han Wanjiang; Christen Philipp
Mechanism of the targeting action of DnaJ in the DnaK molecular chaperone system.
The Journal of biological chemistry 2003;278(21):19038-43.
2003: Grimshaw John P A; Jelesarov Ilian; Siegenthaler Rahel K; Christen Philipp
Thermosensor action of GrpE. The DnaK chaperone system at heat shock temperatures.
The Journal of biological chemistry 2003;278(21):19048-53.
2003: Bischofberger Pius; Han Wanjiang; Feifel Bastian; Schönfeld Hans-Joachim; Christen Philipp
D-Peptides as inhibitors of the DnaK/DnaJ/GrpE chaperone system.
The Journal of biological chemistry 2003;278(21):19044-7.
2003: Han Wanjiang; Christen Philipp
Interdomain communication in the molecular chaperone DnaK.
The Biochemical journal 2003;369(Pt 3):627-34.
2002: Koller Michael F; Grau Thomas; Christen Philipp
Induction of antibodies against murine full-length prion protein in wild-type mice.
Journal of neuroimmunology 2002;132(1-2):113-6.
2002: Gramatikova Svetlana; Mouratou Barbara; Stetefeld Jörg; Mehta Perdeep K; Christen Philipp
Pyridoxal-5'-phosphate-dependent catalytic antibodies.
Journal of immunological methods 2002;269(1-2):99-110.
2002: Koller Michael F; Baici Antonio; Huber Michael; Christen Philipp
Detection of a very rapid first phase in complex formation of DnaK and peptide substrate.
FEBS letters 2002;520(1-3):25-9.
2001: Han W; Christen P
Mutations in the interdomain linker region of DnaK abolish the chaperone action of the DnaK/DnaJ/GrpE system.
FEBS letters 2001;497(1):55-8.
2001: Grimshaw J P; Jelesarov I; Schönfeld H J; Christen P
Reversible thermal transition in GrpE, the nucleotide exchange factor of the DnaK heat-shock system.
The Journal of biological chemistry 2001;276(9):6098-104.
2001: Christen P; Mehta P K
From cofactor to enzymes. The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.
Chemical record (New York, N.Y.) 2001;1(6):436-47.
2000: Mouratou B; Gramatikova S; Kunz B; Christen P
Amino acid sequences and hapten binding of catalytic and noncatalytic antibodies against N(alpha)-(5'-phosphopyridoxyl)-L-lysine.
Molecular immunology 2000;37(11):633-40.
2000: Kasper P; Christen P; Gehring H
Empirical calculation of the relative free energies of peptide binding to the molecular chaperone DnaK.
Proteins 2000;40(2):185-92.
2000: Manunta M; Kunz B; Sandmeier E; Christen P; Schindler H
Reported channel formation by prion protein fragment 106-126 in planar lipid bilayers cannot be reproduced.
FEBS letters 2000;474(2-3):255-6.
2000: Widmann M; Christen P
Comparison of folding rates of homologous prokaryotic and eukaryotic proteins.
The Journal of biological chemistry 2000;275(25):18619-22.
2000: Salzmann D; Christen P; Mehta P K; Sandmeier E
Rates of evolution of pyridoxal-5'-phosphate-dependent enzymes.
Biochemical and biophysical research communications 2000;270(2):576-80.
2000: Gramatikova S I; Christen P
Pyridoxal-5'-phosphate-dependent catalytic antibodies.
Applied biochemistry and biotechnology 2000;83(1-3):183-90; discussion 190-3, 297-313.
2000: Mehta P K; Christen P
The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.
Advances in enzymology and related areas of molecular biology 2000;74():129-84.
1999: Graber R; Kasper P; Malashkevich V N; Strop P; Gehring H; Jansonius J N; Christen P
Conversion of aspartate aminotransferase into an L-aspartate beta-decarboxylase by a triple active-site mutation.
The Journal of biological chemistry 1999;274(44):31203-8.
1999: Mahon M M; Graber R; Christen P; Malthouse J P
The aspartate aminotransferase-catalysed exchange of the alpha-protons of aspartate and glutamate: the effects of the R386A and R292V mutations on this exchange reaction.
Biochimica et biophysica acta 1999;1434(1):191-201.
1999: Kunz B; Sandmeier E; Christen P
Neurotoxicity of prion peptide 106-126 not confirmed.
FEBS letters 1999;458(1):65-8.
1999: Sandmeier E; Hunziker P; Kunz B; Sack R; Christen P
Spontaneous deamidation and isomerization of Asn108 in prion peptide 106-126 and in full-length prion protein.
Biochemical and biophysical research communications 1999;261(3):578-83.
1999: Mehta P K; Argos P; Barbour A D; Christen P
Recognizing very distant sequence relationships among proteins by family profile analysis.
Proteins 1999;35(4):387-400.
1999: Mouratou B; Kasper P; Gehring H; Christen P
Conversion of tyrosine phenol-lyase to dicarboxylic amino acid beta-lyase, an enzyme not found in nature.
The Journal of biological chemistry 1999;274(3):1320-5.
1998: Pierpaoli E V; Gisler S M; Christen P
Sequence-specific rates of interaction of target peptides with the molecular chaperones DnaK and DnaJ.
Biochemistry 1998;37(47):16741-8.
1998: Gisler S M; Pierpaoli E V; Christen P
Catapult mechanism renders the chaperone action of Hsp70 unidirectional.
Journal of molecular biology 1998;279(4):833-40.
1998: Mahon M M; Gramatikova S I; Christen P; Fitzpatrick T B; Malthouse J P
The pyridoxal-5'-phosphate-dependent catalytic antibody 15A9: its efficiency and stereospecificity in catalysing the exchange of the alpha-protons of glycine.
FEBS letters 1998;427(1):74-8.
1998: Feifel B; Schönfeld H J; Christen P
D-peptide ligands for the co-chaperone DnaJ.
The Journal of biological chemistry 1998;273(20):11999-2002.
1998: Pierpaoli E V; Sandmeier E; Schönfeld H J; Christen P
Control of the DnaK chaperone cycle by substoichiometric concentrations of the co-chaperones DnaJ and GrpE.
The Journal of biological chemistry 1998;273(12):6643-9.
1997: Vacca R A; Giannattasio S; Graber R; Sandmeier E; Marra E; Christen P
Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.
The Journal of biological chemistry 1997;272(35):21932-7.
1997: Pierpaoli E V; Sandmeier E; Baici A; Schönfeld H J; Gisler S; Christen P
The power stroke of the DnaK/DnaJ/GrpE molecular chaperone system.
Journal of molecular biology 1997;269(5):757-68.
1997: Gramatikova S I; Christen P
Monoclonal antibodies against Nalpha-(5'-phosphopyridoxyl)-L-lysine. Screening and spectrum of pyridoxal 5'-phosphate-dependent activities toward amino acids.
The Journal of biological chemistry 1997;272(15):9779-84.
1997: Chen M; Christen P
Removal of chromosomal DNA by Mg2+ in the lysis buffer: an improved lysis protocol for preparing Escherichia coli whole-cell lysates for sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Analytical biochemistry 1997;246(2):263-4.
1996: Gramatikova S I; Christen P
Pyridoxal 5'-phosphate-dependent catalytic antibody.
The Journal of biological chemistry 1996;271(48):30583-6.
1996: Kasper P; Sterk M; Christen P; Gehring H
Molecular-dynamics simulation of domain movements in aspartate aminotransferase.
European journal of biochemistry / FEBS 1996;240(3):751-5.
1996: Christen P; Kasper P; Gehring H; Sterk M
Stereochemical constraint in the evolution of pyridoxal-5'-phosphate-dependent enzymes. A hypothesis.
FEBS letters 1996;389(1):12-4.
1996: Feifel B; Sandmeier E; Schönfeld H J; Christen P
Potassium ions and the molecular-chaperone activity of DnaK.
European journal of biochemistry / FEBS 1996;237(1):318-21.
1996: Markovic-Housley Z; Schirmer T; Hohenester E; Khomutov A R; Khomutov R M; Karpeisky M Y; Sandmeier E; Christen P; Jansonius J N
Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
European journal of biochemistry / FEBS 1996;236(3):1025-32.
1995: Widmann M; Christen P
Differential effects of molecular chaperones on refolding of homologous proteins.
FEBS letters 1995;377(3):481-4.
1995: Graber R; Kasper P; Malashkevich V N; Sandmeier E; Berger P; Gehring H; Jansonius J N; Christen P
Changing the reaction specificity of a pyridoxal-5'-phosphate-dependent enzyme.
European journal of biochemistry / FEBS 1995;232(2):686-90.
1995: Vacca R A; Christen P; Malashkevich V N; Jansonius J N; Sandmeier E
Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity.
European journal of biochemistry / FEBS 1995;227(1-2):481-7.
1995: Malashkevich V N; Jäger J; Ziak M; Sauder U; Gehring H; Christen P; Jansonius J N
Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue.
Biochemistry 1995;34(2):405-14.
1994: Pan P; Jakob C A; Sandmeier E; Christen P; Gehring H
Modulation of the activity of mitochondrial aspartate aminotransferase H352C by the redox state of the engineered interdomain disulfide bond.
The Journal of biological chemistry 1994;269(41):25432-6.
1994: Sandmeier E; Hale T I; Christen P
Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.
European journal of biochemistry / FEBS 1994;221(3):997-1002.
1994: Pan P; Jaussi R; Gehring H; Giannattasio S; Christen P
Shift in pH-rate profile and enhanced discrimination between dicarboxylic and aromatic substrates in mitochondrial aspartate aminotransferase Y70H.
Biochemistry 1994;33(10):2757-60.
1994: Schmid D; Baici A; Gehring H; Christen P
Kinetics of molecular chaperone action.
Science (New York, N.Y.) 1994;263(5149):971-3.
1994: Alexander F W; Sandmeier E; Mehta P K; Christen P
Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families.
European journal of biochemistry / FEBS 1994;219(3):953-60.
1994: Mehta P K; Christen P
Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7-oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2-dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases.
Biochemical and biophysical research communications 1994;198(1):138-43.
1993: Hartmann C M; Gehring H; Christen P
The mature form of imported mitochondrial proteins undergoes conformational changes upon binding to isolated mitochondria.
European journal of biochemistry / FEBS 1993;218(3):905-10.
1993: Mehta P K; Christen P
A comment on: 'Homology of the NifS family of proteins to a new class of pyridoxal phosphate-dependent enzymes', by Christos Ouzounis and Chris Sander (1993) FEBS Lett. 322, 159-164.
FEBS letters 1993;330(2):241-2.
1993: Pan P; Schinzel R; Palm D; Christen P
Reaction of imidazole-citrate-deformed glycogen phosphorylase with amino acids.
European journal of biochemistry / FEBS 1993;215(3):761-6.
1993: Mehta P K; Hale T I; Christen P
Aminotransferases: demonstration of homology and division into evolutionary subgroups.
European journal of biochemistry / FEBS 1993;214(2):549-61.
1993: Gupta S; Hollenstein R; Kochhar S; Christen P
Paracatalytic self-inactivation of fructose-1,6-bisphosphate aldolase. Structure of the crosslink formed at the active site.
European journal of biochemistry / FEBS 1993;214(2):515-9.
1993: Ziak M; Jäger J; Malashkevich V N; Gehring H; Jaussi R; Jansonius J N; Christen P
Mutant aspartate aminotransferase (K258H) without pyridoxal-5'-phosphate-binding lysine residue. Structural and catalytic properties.
European journal of biochemistry / FEBS 1993;211(3):475-84.
1993: Mehta P K; Christen P
Homology of pyridoxal-5'-phosphate-dependent aminotransferases with the cobC (cobalamin synthesis), nifS (nitrogen fixation), pabC (p-aminobenzoate synthesis) and malY (abolishing endogenous induction of the maltose system) gene products.
European journal of biochemistry / FEBS 1993;211(1-2):373-6.
1992: Schmid D; Jaussi R; Christen P
Precursor of mitochondrial aspartate aminotransferase synthesized in Escherichia coli is complexed with heat-shock protein DnaK.
European journal of biochemistry / FEBS 1992;208(3):699-704.
1992: Kochhar S; Christen P
Mechanism of racemization of amino acids by aspartate aminotransferase.
European journal of biochemistry / FEBS 1992;203(3):563-9.
1991: Picot D; Sandmeier E; Thaller C; Vincent M G; Christen P; Jansonius J N
The open/closed conformational equilibrium of aspartate aminotransferase. Studies in the crystalline state and with a fluorescent probe in solution.
European journal of biochemistry / FEBS 1991;196(2):329-41.
1991: Hartmann C M; Lindenmann J M; Christen P; Jaussi R
The precursor of mitochondrial aspartate aminotransferase is imported into mitochondria faster than the homologous cytosolic isoenzyme with the same presequence attached.
Biochemical and biophysical research communications 1991;174(3):1232-8.
1990: Juretic N; Mattes U; Ziak M; Christen P; Jaussi R
Structure of the genes of two homologous intracellularly heterotopic isoenzymes. Cytosolic and mitochondrial aspartate aminotransferase of chicken.
European journal of biochemistry / FEBS 1990;192(1):119-26.
1990: Ziak M; Jaussi R; Gehring H; Christen P
Aspartate aminotransferase with the pyridoxal-5'-phosphate-binding lysine residue replaced by histidine retains partial catalytic competence.
European journal of biochemistry / FEBS 1990;187(2):329-33.
1990: Christen P; Jaussi R; Juretic N; Mehta P K; Hale T I; Ziak M
Evolutionary and biosynthetic aspects of aspartate aminotransferase isoenzymes and other aminotransferases.
Annals of the New York Academy of Sciences 1990;585():331-8.
1989: Mehta P K; Hale T I; Christen P
Evolutionary relationships among aminotransferases. Tyrosine aminotransferase, histidinol-phosphate aminotransferase, and aspartate aminotransferase are homologous proteins.
European journal of biochemistry / FEBS 1989;186(1-2):249-53.
1989: Kochhar S; Mehta P K; Christen P
Assay for aliphatic amino acid decarboxylases by high-performance liquid chromatography.
Analytical biochemistry 1989;179(1):182-5.
1989: Kochhar S; Christen P
Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide.
Analytical biochemistry 1989;178(1):17-21.
1989: Mattes U; Jaussi R; Ziak M; Juretic N; Lindenmann J M; Christen P
Structure of cDNA of cytosolic aspartate aminotransferase of chicken and its expression in E. coli.
Biochimie 1989;71(4):411-6.
1988: Kochhar S; Christen P
The enantiomeric error frequency of aspartate aminotransferase.
European journal of biochemistry / FEBS 1988;175(2):433-8.
1988: Flückiger J; Christen P
Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts.
The Journal of biological chemistry 1988;263(9):4131-8.
1987: Juretic N; Jaussi R; Mattes U; Christen P
Genes of nuclear encoded mitochondrial proteins: evidence for a variant of the 3' splice-site consensus sequence.
Nucleic acids research 1987;15(24):10083-6.
1987: Jaussi R; Behra R; Giannattasio S; Flura T; Christen P
Expression of cDNAs encoding the precursor and the mature form of chicken mitochondrial aspartate aminotransferase in Escherichia coli.
The Journal of biological chemistry 1987;262(26):12434-7.
1985: Jaussi R; Cotton B; Juretic N; Christen P; Schümperli D
The primary structure of the precursor of chicken mitochondrial aspartate aminotransferase. Cloning and sequence analysis of cDNA.
The Journal of biological chemistry 1985;260(30):16060-3.
1985: Pfister K; Sandmeier E; Berchtold W; Christen P
Conformational changes in aspartate aminotransferase. Effect of active site ligands on peptide hydrogen-deuterium exchange.
The Journal of biological chemistry 1985;260(21):11414-21.
1984: Christen P; Gehring H; Sandmeier E; Kirsten H; Pfister K; Jansonius J N
Correlation of structure and catalysis by aspartate aminotransferase isoenzymes.
Biochemical Society transactions 1984;12(3):427-30.
1984: Jansonius J N; Eichele G; Ford G C; Kirsch J F; Picot D; Thaller C; Vincent M G; Gehring H; Christen P
Three-dimensional structure of mitochondrial aspartate aminotransferase and some functional derivatives: implications for its mode of action.
Biochemical Society transactions 1984;12(3):424-7.
1984: Kirsch J F; Eichele G; Ford G C; Vincent M G; Jansonius J N; Gehring H; Christen P
Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure.
Journal of molecular biology 1984;174(3):497-525.
1984: Jaussi R; Flückiger J; Behra R; Christen P
Inhibitors of maturation and degradation of the precursor of mitochondrial aspartate aminotransferase.
Progress in clinical and biological research 1984;144B():27-32.
1984: Vincent M G; Picot D; Eichele G; Jansonius J N; Kirsten H; Christen P
Linear dichroism measurements on single crystals of mitochondrial aspartate aminotransferase.
Progress in clinical and biological research 1984;144B():233-43.
1984: Gehring H; Sandmeier E; Kirsten H; Carrassi R; Christen P; Jansonius J N
Aspartate aminotransferase: studies on conformational adaptions and 3H-transfer during transamination.
Progress in clinical and biological research 1984;144B():223-31.
1984: Jansonius J N; Eichele G; Ford G C; Kirsch J F; Picot D; Thaller C; Vincent M G; Gehring H; Christen P
Crystallographic studies on the mechanism of action of mitochondrial aspartate aminotransferase.
Progress in clinical and biological research 1984;144B():195-203.
1984: Christen P; Jaussi R; Sonderegger P; Gehring H; Graf-Hausner U; Behra R; Flückiger J; Skoda R C
Biosynthesis of aspartate aminotransferases.
Progress in clinical and biological research 1984;144B():17-25.
1983: Kirsten H; Gehring H; Christen P
Crystalline aspartate aminotransferase: lattice-induced functional asymmetry of the two subunits.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(7):1807-10.
1982: Jaussi R; Sonderegger P; Flückiger J; Christen P
Biosynthesis and topogenesis of aspartate aminotransferase isoenzymes in chicken embryo fibroblasts. The precursor of the mitochondrial isoenzyme is either imported into mitochondria or degraded in the cytosol.
The Journal of biological chemistry 1982;257(22):13334-40.
1982: Sonderegger P; Jaussi R; Christen P; Gehring H
Biosynthesis of aspartate aminotransferases. Both the higher molecular weight precursor of mitochondrial aspartate aminotransferase and the cytosolic isoenzyme are synthesized on free polysomes.
The Journal of biological chemistry 1982;257(6):3339-45.
1981: Wacker H; Jaussi R; Sonderegger P; Dokow M; Ghersa P; Hauri H P; Christen P; Semenza G
Cell-free synthesis of the one-chain precursor of a major intrinsic protein complex of the small-intestinal brush border membrane (pro-sucrase-isomaltase).
FEBS letters 1981;136(2):329-32.
1981: Behra R; Christen P; Sonderegger P
Independent quantitation of the mitochondrial and the cytosolic isoenzyme of aspartate aminotransferase in chicken tissues by radioimmunoassays.
The Journal of biological chemistry 1981;256(7):3381-4.
1980: Sonderegger P; Jaussi R; Christen P
Cell-free synthesis of a putative precursor of mitochondrial aspartate aminotransferase with higher molecular weight.
Biochemical and biophysical research communications 1980;94(4):1256-60.

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