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RD Christen

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

Physiology

Disorders

Procedures

Drug Screening Assays, Antitumor

Co-author Network

Publications

TOP 3
H Niedner; RD Christen; Xinjian Lin; Akira Kondo; Stephen B Howell
Identification of genes that mediate sensitivity to cisplatin.
N Onoda; A Nehmi; D Weiner; S Mujumdar; RD Christen; Gerrit Los
Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents.
A Nehmé; P Varadarajan; G Sellakumar; M Gerhold; H Niedner; Q Zhang; Xinjian Lin; RD Christen
Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells.

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All Publications

2001: H Niedner; RD Christen; Xinjian Lin; Akira Kondo; Stephen B Howell
Identification of genes that mediate sensitivity to cisplatin.
Molecular pharmacology 2001;60(6):1153-60.
2001: N Onoda; A Nehmi; D Weiner; S Mujumdar; RD Christen; Gerrit Los
Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents.
Head & neck 2001;23(10):860-70.
2001: A Nehmé; P Varadarajan; G Sellakumar; M Gerhold; H Niedner; Q Zhang; Xinjian Lin; RD Christen
Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells.
British journal of cancer 2001;84(11):1571-6.
2001: B Cenni; Stefan Aebi; A Nehmé; RD Christen
Epidermal growth factor enhances cisplatin-induced apoptosis by a caspase 3 independent pathway.
Cancer chemotherapy and pharmacology 2001;47(5):397-403.
2001: Xinjian Lin; K Ramamurthi; Misako Mishima; Akira Kondo; RD Christen; Stephen B Howell
P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.
Cancer research 2001;61(4):1508-16.
2000: A Nehmé; B L Lee; R Baskaran; Q Zhang; Xinjian Lin; RD Christen
Effect of c-Abl tyrosine kinase on the cellular response to paclitaxel-induced microtubule damage.
British journal of cancer 2000;83(10):1360-6.
2000: Maida M de las Alas; RD Christen; DP Gately; D E Weiner; K Benbatoul; S Kirmani; H R D'Agostino; Steven C Plaxe; D Darrah; EF McClay; Stefan Aebi; Stephen B Howell; Gerrit Los
Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel.
Cancer chemotherapy and pharmacology 2000;45(5):381-8.
1999: Gerrit Los; K Benbatoul; DP Gately; R Barton; RD Christen; K T Robbins; D Vicario; S Kirmani; Lisa A Orloff; R Weisman; Stephen B Howell
Quantitation of the change in GADD153 messenger RNA level as a molecular marker of tumor response in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1610-8.
1999: B Cenni; H K Kim; G J Bubley; Stefan Aebi; D Fink; B A Teicher; Stephen B Howell; RD Christen
Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin.
British journal of cancer 1999;80(5-6):699-704.
1999: A Nehmé; R Baskaran; S Nebel; D Fink; Stephen B Howell; Jean Y J Wang; RD Christen
Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells.
British journal of cancer 1999;79(7-8):1104-10.
1999: Stefan Aebi; T W Schnider; Gerrit Los; D D Heath; D Darrah; S Kirmani; EF McClay; HB D'Agostino; Steven C Plaxe; D Fink; Maida M de las Alas; Stephen B Howell; RD Christen
A phase II/pharmacokinetic trial of high-dose progesterone in combination with paclitaxel.
Cancer chemotherapy and pharmacology 1999;44(3):259-65.
1997: Stefan Aebi; R Kröning; B Cenni; A Sharma; D Fink; Gerrit Los; R Weisman; Stephen B Howell; RD Christen
all-trans retinoic acid enhances cisplatin-induced apoptosis in human ovarian adenocarcinoma and in squamous head and neck cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2033-8.
1997: A Nehmé; R Baskaran; Stefan Aebi; D Fink; S Nebel; B Cenni; Jean Y J Wang; Stephen B Howell; RD Christen
Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.
Cancer research 1997;57(15):3253-7.
1997: Jeffrey Jones; K D Albright; RD Christen; Stephen B Howell; EF McClay
Synergy between tamoxifen and cisplatin in human melanoma cells is dependent on the presence of antiestrogen-binding sites.
Cancer research 1997;57(13):2657-60.
1997: D Fink; H Zheng; S Nebel; Paula S Norris; Stefan Aebi; T P Lin; A Nehmé; RD Christen; M Haas; Carol L MacLeod; Stephen B Howell
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair.
Cancer research 1997;57(10):1841-5.
1997: EF McClay; M E McClay; Jeffrey Jones; P J Winski; RD Christen; Stephen B Howell; Philip D Hall
A phase I and pharmacokinetic study of high dose tamoxifen and weekly cisplatin in patients with metastatic melanoma.
Cancer 1997;79(5):1037-43.
1997: D Fink; S Nebel; Stefan Aebi; H Zheng; HK Kim; RD Christen; Stephen B Howell
Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
British journal of cancer 1997;76(7):890-3.
1996: D Fink; S Nebel; Stefan Aebi; H Zheng; B Cenni; A Nehmé; RD Christen; Stephen B Howell
The role of DNA mismatch repair in platinum drug resistance.
Cancer research 1996;56(21):4881-6.
1996: EF McClay; Jeffrey Jones; P J Winski; K D Albright; RD Christen; Stephen B Howell
Determinants of tamoxifen sensitivity control the nature of the synergistic interaction between tamoxifen and cisplatin.
Cancer research 1996;56(17):3993-7.
1996: Stefan Aebi; Buran Kurdi-Haidar; R Gordon; B Cenni; H Zheng; D Fink; RD Christen; C Richard Boland; M Koi; R Fishel; Stephen B Howell
Loss of DNA mismatch repair in acquired resistance to cisplatin.
Cancer research 1996;56(13):3087-90.
1996: D P Gately; A Sharma; RD Christen; Stephen B Howell
Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153.
British journal of cancer 1996;73(1):18-23.
1995: R Kröning; Jeffrey Jones; D K Hom; C C Chuang; R Sanga; Gerrit Los; Stephen B Howell; RD Christen
Enhancement of drug sensitivity of human malignancies by epidermal growth factor.
British journal of cancer 1995;72(3):615-9.
1994: EF McClay; K D Albright; Jeffrey Jones; RD Christen; Stephen B Howell
Tamoxifen delays the development of resistance to cisplatin in human melanoma and ovarian cancer cell lines.
British journal of cancer 1994;70(3):449-52.
1994: RD Christen; Seiji Isonishi; Jeffrey Jones; Antti Jekunen; D K Hom; R Kröning; D P Gately; F B Thiebaut; Gerrit Los; Stephen B Howell
Signaling and drug sensitivity.
Cancer metastasis reviews 1994;13(2):175-89.
1994: Antti Jekunen; RD Christen; D R Shalinsky; Stephen B Howell
Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro.
British journal of cancer 1994;69(2):299-306.
1993: EF McClay; K D Albright; Jeffrey Jones; RD Christen; Stephen B Howell
Tamoxifen modulation of cisplatin cytotoxicity in human malignancies.
International journal of cancer. Journal international du cancer 1993;55(6):1018-22.
1993: RD Christen; EF McClay; Steven C Plaxe; Samuel S C Yen; S Kim; S Kirmani; L L Wilgus; D D Heath; D R Shalinsky; J L Freddo
Phase I/pharmacokinetic study of high-dose progesterone and doxorubicin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(12):2417-26.
1993: Steven C Plaxe; P S Braly; J L Freddo; EF McClay; RD Christen; S Kirmani; S Kim; D Heath; Stephen B Howell
Phase I and pharmacokinetic study of intraperitoneal ormaplatin.
Gynecologic oncology 1993;51(1):72-7.
1993: E F Mc Clay; M E Mc Clay; K D Albright; Jeffrey Jones; RD Christen; J Alcaraz; Stephen B Howell
Tamoxifen modulation of cisplatin resistance in patients with metastatic melanoma. A biologically important observation.
Cancer 1993;72(6):1914-8.
1993: RD Christen; Antti Jekunen; Jeffrey Jones; F Thiebaut; D R Shalinsky; Stephen B Howell
In vitro modulation of cisplatin accumulation in human ovarian carcinoma cells by pharmacologic alteration of microtubules.
The Journal of clinical investigation 1993;92(1):431-40.
1993: EF McClay; K D Albright; Jeffrey Jones; RD Christen; Stephen B Howell
Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells.
Cancer research 1993;53(7):1571-6.
1993: D R Shalinsky; Antti Jekunen; J E Alcaraz; RD Christen; S Kim; S Khatibi; Stephen B Howell
Regulation of initial vinblastine influx by P-glycoprotein.
British journal of cancer 1993;67(1):30-6.
1992: Seiji Isonishi; Antti Jekunen; D K Hom; A Eastman; P S Edelstein; F B Thiebaut; RD Christen; Stephen B Howell
Modulation of cisplatin sensitivity and growth rate of an ovarian carcinoma cell line by bombesin and tumor necrosis factor-alpha.
The Journal of clinical investigation 1992;90(4):1436-42.
1992: RD Christen; D R Shalinsky; Stephen B Howell
Enhancement of the loss of multiple drug resistance by hydroxyurea.
Seminars in oncology 1992;19(3 Suppl 9):94-100.
1991: Stephen B Howell; Seiji Isonishi; RD Christen; P A Andrews; S Mann
Cellular pharmacologic strategies for overcoming drug resistance: potential applications to regional therapy.
The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 1991;(561):45-8.
1990: RD Christen; D K Hom; D C Porter; P A Andrews; Carol L MacLeod; L Hafstrom; Stephen B Howell
Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin.
The Journal of clinical investigation 1990;86(5):1632-40.
1990: RD Christen; F J Wagenhäuser; K A Neftel
Heat induced radial segmentation of leukocyte nuclei in patients with polymyalgia rheumatica and other inflammatory diseases.
The Journal of rheumatology 1990;17(7):923-8.
1990: RD Christen; R Moser; P Schlup; K A Neftel
Fulminant group A streptococcal infections. Report of two cases.
Klinische Wochenschrift 1990;68(8):427-30.