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Dennis Christensen

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Chemicals & Drugs

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Publications

TOP 3
Pall Thor Ingvarsson; Niels Bent Larsen; Hanne Mørck Nielsen; Jukka Rantanen; Signe Tandrup Schmidt; Mingshi Yang; Peter Andersen; Dennis Christensen; Wouter Leonardus Joseph Hinrichs; Camilla Foged
Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01.
Mette Hamborg; Lene Jorgensen; Anders Riber Bojsen; Dennis Christensen; Camilla Foged
Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics.
Dennis Christensen; Jan P Christensen; Malou Henriksen-Lacey; Arun T Kamath; Karen Smith Korsholm; Paul-Henri Lambert; Thomas Lindenstrøm; Yvonne Perrie; Anne-Francoise Rochat; Claire-Anne Siegrist; Peter Andersen; Else Marie Agger
A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog.

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All Publications

2013: Pall Thor Ingvarsson; Niels Bent Larsen; Hanne Mørck Nielsen; Jukka Rantanen; Signe Tandrup Schmidt; Mingshi Yang; Peter Andersen; Dennis Christensen; Wouter Leonardus Joseph Hinrichs; Camilla Foged
Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01.
Journal of controlled release : official journal of the Controlled Release Society 2013;167(3):256-64.
2013: Mette Hamborg; Lene Jorgensen; Anders Riber Bojsen; Dennis Christensen; Camilla Foged
Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics.
Pharmaceutical research 2013;30(1):140-55.
2012: Dennis Christensen; Jan P Christensen; Malou Henriksen-Lacey; Arun T Kamath; Karen Smith Korsholm; Paul-Henri Lambert; Thomas Lindenstrøm; Yvonne Perrie; Anne-Francoise Rochat; Claire-Anne Siegrist; Peter Andersen; Else Marie Agger
A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(3):468-76.
2012: Karen Smith Korsholm; Peter Lawætz Andersen; Dennis Christensen
Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status.
Expert review of vaccines 2012;11(5):561-77.
2012: Anne-Marie Carola Andersson; Dennis Christensen; Kjell O Håkansson; Benjamin Anderschou Holbech Jensen; Allan Randrup Thomsen; Peter Andersen; Jan Pravsgaard Christensen
Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein.
PloS one 2012;7(10):e46395.
2011: Sagida Bibi; Dennis Christensen; Malou Henriksen-Lacey; Randip Kaur; Eric Lattmann; Sarah E McNeil; Afzal R Mohammed; Jitinder Wilkhu; Yvonne Perrie
Microscopy imaging of liposomes: from coverslips to environmental SEM.
International journal of pharmaceutics 2011;417(1-2):138-50.
2011: Dennis Christensen; Karen Smith Korsholm; Peter Andersen; Else Marie Agger
Cationic liposomes as vaccine adjuvants.
Expert review of vaccines 2011;10(4):513-21.
2011: Malou Henriksen-Lacey; Karen Smith Korsholm; Peter Andersen; Yvonne Perrie; Dennis Christensen
Liposomal vaccine delivery systems.
Expert opinion on drug delivery 2011;8(4):505-19.
2011: Pernille Nordly; Fabrice Rose; Dennis Christensen; Hanne Mørck Nielsen; Peter Andersen; Else Marie Agger; Camilla Foged
Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method.
Journal of controlled release : official journal of the Controlled Release Society 2011;150(3):307-17.
2011: Malou Henriksen-Lacey; Dennis Christensen; Vincent W Bramwell; Thomas Lindenstrøm; Else Marie Agger; Peter Andersen; Yvonne Perrie
Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N',N'-Dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses.
Molecular pharmaceutics 2011;8(1):153-61.
2011: Cyril Jean-Marie Martel; Lars Peter Nielsen; Julie Juul Poulsen; Else Marie Agger; Peter Andersen; Lars Andresen; Merete Blixenkrone-Møller; Dennis Christensen; Trine Hammer Jensen; Bent Aasted
CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets.
PloS one 2011;6(8):e22891.
2010: Malou Henriksen-Lacey; Dennis Christensen; Vincent W Bramwell; Thomas Lindenstrøm; Else Marie Agger; Peter Andersen; Yvonne Perrie
Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response.
Journal of controlled release : official journal of the Controlled Release Society 2010;145(2):102-8.
2010: Dennis Christensen; Camilla Foged; Ida Rosenkrands; Carina Vingsbo Lundberg; Peter Andersen; Else Marie Agger; Hanne Mørck Nielsen
CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations.
International journal of pharmaceutics 2010;390(1):19-24.
2010: Malou Henriksen-Lacey; Vincent W Bramwell; Dennis Christensen; Else Marie Agger; Peter Andersen; Yvonne Perrie
Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):180-6.
2010: Dennis Christensen; Thomas Lindenstrøm; Gijsbert van de Wijdeven; Peter Andersen; Else Marie Agger
Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.
PloS one 2010;5(11):e15043.
2010: Anja Weinreich Olsen; Michael Theisen; Dennis Christensen; Frank Follmann; Peter Andersen
Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model.
PloS one 2010;5(5):e10768.
2009: Claire A Swetman Andersen; Ida Rosenkrands; Anja W Olsen; Pernille Nordly; Dennis Christensen; Roland Lang; Carsten Kirschning; Jessica M Gomes; Veemal Bhowruth; David E Minnikin; Gurdyal S Besra; Frank Follmann; Peter Andersen; Else Marie Agger
Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2294-302.
2008: Dennis Christensen; Morten Allesø; Ida Rosenkrands; Jukka Rantanen; Camilla Foged; Else Marie Agger; Peter Andersen; Hanne Mørck Nielsen
NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(3):914-20.
2008: Dennis Christensen; Daniel Kirby; Camilla Foged; Else Marie Agger; Peter Andersen; Yvonne Perrie; Hanne Mørck Nielsen
alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying.
Biochimica et biophysica acta 2008;1778(5):1365-73.
2008: Else Marie Agger; Ida Rosenkrands; Jon Hansen; Karima Brahimi; Brian S Vandahl; Claus Aagaard; Kerstin Werninghaus; Carsten Kirschning; Roland Lang; Dennis Christensen; Michael Theisen; Frank Follmann; Peter Andersen
Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements.
PloS one 2008;3(9):e3116.
2007: Dennis Christensen; Karen Smith Korsholm; Ida Rosenkrands; Thomas Lindenstrøm; Peter Andersen; Else Marie Agger
Cationic liposomes as vaccine adjuvants.
Expert review of vaccines 2007;6(5):785-96.
2007: Dennis Christensen; Camilla Foged; Ida Rosenkrands; Hanne Mørck Nielsen; Peter Andersen; Else Marie Agger
Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying.
Biochimica et biophysica acta 2007;1768(9):2120-9.
2007: Karen Smith Korsholm; Else Marie Agger; Camilla Foged; Dennis Christensen; Jes Dietrich; Claire Swetman Andersen; Carsten Geisler; Peter Andersen
The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes.
Immunology 2007;121(2):216-26.
2007: Anil Vangala; Vincent W Bramwell; Sarah E McNeil; Dennis Christensen; Else Marie Agger; Yvonne Perrie
Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(1):102-10.
2005: Jesper Davidsen; Ida Rosenkrands; Dennis Christensen; Anil Vangala; Daniel Kirby; Yvonne Perrie; Else Marie Agger; Peter Andersen
Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses.
Biochimica et biophysica acta 2005;1718(1-2):22-31.