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Uwe Christians
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46
Sewing, KF
29
Benet, Leslie
23
Serkova, Natalie
19
Jacobsen, Wolfgang
17
morris, randall
16
Hausen, Bernard
16
Bleck, Jörg
14
Pichlmayr, Rudolf
14
Wonigeit, Kurt
13
Leibfritz, Dieter
12
Kohlhaw, Kay
12
Bendrick-Peart, Jamie
11
Bader, Augustinus
10
Haschke, Manuel
9
Winkler, Michael
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All Publications
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2009: Klawitter Jelena; Zhang Yan Ling; Klawitter Jost; Anderson Nora; Serkova Natalie J; Christians Uwe
Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.
Biomedical chromatography : BMC 2009;23(12):1251-8.
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2009: Clavijo Claudia; Strom Tobin; Moll Vanessa; Betts Ronald; Zhang Yan Ling; Christians Uwe; Bendrick-Peart Jamie
Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3506-14.
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2009: Marusyk Andriy; Casás-Selves Matias; Henry Curtis J; Zaberezhnyy Vadym; Klawitter Jelena; Christians Uwe; DeGregori James
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
Cancer research 2009;69(18):7262-9.
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2009: Klawitter Jelena; Kominsky Douglas J; Brown Jaimi L; Klawitter Jost; Christians Uwe; Leibfritz Dieter; Melo Junia V; Eckhardt S Gail; Serkova Natalie J
Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells.
British journal of pharmacology 2009;158(2):588-600.
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2009: Tissot van Patot Martha C; Serkova Natalie J; Haschke Manuel; Kominsky Douglas J; Roach Robert C; Christians Uwe; Henthorn Thomas K; Honigman Benjamin
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
Free radical biology & medicine 2009;46(11):1551-7.
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2009: Klawitter J; Anderson N; Klawitter J; Christians U; Leibfritz D; Eckhardt S G; Serkova N J
Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study.
British journal of cancer 2009;100(6):923-31.
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2009: Filler Guido; Bendrick-Peart Jamie; Strom Tobin; Zhang Yan Ling; Johnson Gillian; Christians Uwe
Characterization of sirolimus metabolites in pediatric solid organ transplant recipients.
Pediatric transplantation 2009;13(1):44-53.
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2009: Klawitter Jost; Bendrick-Peart Jamie; Rudolph Birgit; Beckey Virginia; Klawitter Jelena; Haschke Manuel; Rivard Christopher; Chan Laurence; Leibfritz Dieter; Christians Uwe; Schmitz Volker
Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.
Chemical research in toxicology 2009;22(1):118-28.
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2009: Schmitz Volker; Klawitter Jost; Bendrick-Peart Jamie; Schoening Wenzel; Puhl Gero; Haschke Manuel; Klawitter Jelena; Consoer Jeff; Rivard Christopher J; Chan Laurence; Tran Zung V; Leibfritz Dieter; Christians Uwe
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation.
Nephron. Experimental nephrology 2009;111(4):e80-91.
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2008: Ostojic Miodrag; Sagic Dragan; Jung Robert; Zhang Yan-Ling; Nedeljkovic Milan; Mangovski Ljupco; Stojkovic Sinisa; Debeljacki Dragan; Colic Mirko; Beleslin Branko; Milosavljevic Bratislav; Orlic Dejan; Topic Dragan; Karanovic Nevena; Paunovic Dragica; Christians Uwe;
The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2008;72(7):901-8.
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2008: Kupfer René; Swanson Leah; Chow Sylvia; Staub Richard E; Zhang Yan Ling; Cohen Isaac; Christians Uwe
Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2261-9.
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2008: Clavijo Claudia; Bendrick-Peart Jamie; Zhang Yan Ling; Johnson Gillian; Gasparic Antje; Christians Uwe
An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;874(1-2):33-41.
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2008: Christians Uwe; Schmitz Volker; Schöning Wenzel; Bendrick-Peart Jamie; Klawitter Jelena; Haschke Manuel; Klawitter Jost
Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges.
Therapeutic drug monitoring 2008;30(2):151-8.
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2008: Filler Guido; Bendrick-Peart Jamie; Christians Uwe
Pharmacokinetics of mycophenolate mofetil and sirolimus in children.
Therapeutic drug monitoring 2008;30(2):138-42.
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2008: Klawitter Jost; Rivard Christopher J; Brown Lewis M; Capasso Juan M; Almeida Nestor E; Maunsbach Arvid B; Pihakaski-Maunsbach Kaarina; Berl Tomas; Leibfritz Dieter; Christians Uwe; Chan Laurence
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity.
Nephron. Physiology 2008;109(1):p1-10.
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2007: Strom Tobin; Haschke Manuel; Boyd Jared; Roberts Mark; Arabshahi Lili; Marbach Peter; Christians Uwe
Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus.
Therapeutic drug monitoring 2007;29(6):743-9.
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2007: Strom Tobin; Haschke Manuel; Zhang Yan Ling; Bendrick-Peart Jamie; Boyd Jared; Roberts Mark; Arabshahi Lili; Marbach Peter; Christians Uwe
Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients.
Therapeutic drug monitoring 2007;29(5):592-9.
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2007: Laudi Sven; Trump Saskia; Schmitz Volker; West James; McMurtry Ivan F; Mutlak Haitham; Christians Uwe; Weimann Jörg; Kaisers Udo; Steudel Wolfgang
Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.
American journal of physiology. Lung cellular and molecular physiology 2007;293(3):L630-8.
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2007: Laudi Sven; Steudel Wolfgang; Jonscher Karen; Schöning Wenzel; Schniedewind Björn; Kaisers Udo; Christians Uwe; Trump Saskia
Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension.
Proteomics 2007;7(14):2469-78.
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2007: Boernsen K Olaf; Egge-Jacobsen Wolfgang; Inverardi Bruno; Strom Tobin; Streit Frank; Schiebel Hans-Martin; Benet Leslie Z; Christians Uwe
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
Journal of mass spectrometry : JMS 2007;42(6):793-802.
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2007: Klawitter Jost; Schmitz Volker; Klawitter Jelena; Leibfritz Dieter; Christians Uwe
Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS.
Analytical biochemistry 2007;365(2):230-9.
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2007: Perry Theodore W; Christians Uwe; Trotter James F; Bendrick-Peart Jamie
Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients.
Clinical transplantation 2007;21(3):413-6.
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2007: Laudi S; Weimann J; Haschke M; Trump S; Schmitz V; Christians U; Kaisers U; Steudel W
Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58(1):19-32.
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2007: Haschke Manuel; Zhang Yan Ling; Kahle Christine; Klawitter Jelena; Korecka Magdalena; Shaw Leslie M; Christians Uwe
HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma.
Clinical chemistry 2007;53(3):489-97.
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2007: Ng Ka-yun; Zhou Huiyu; Zhang Yan Ling; Hybertson Brooks; Randolph Theodore; Christians Uwe
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):188-98.
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2006: Christians Uwe; Strom Tobin; Zhang Yan Ling; Steudel Wolfgang; Schmitz Volker; Trump Saskia; Haschke Manuel
Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics.
Therapeutic drug monitoring 2006;28(1):39-44.
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2006: Schmitz Volker; Klawitter Jost; Bendrick-Peart Jamie; Haschke Manuel; Beckey Virginia E; Laudi Sven; Neumann Ulf; Schoening Wenzel; Neuhaus Peter; Christians Uwe; Puhl Gero
Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006;38(4):388-98.
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2006: Van Patot Martha C Tissot; Hill Ashley E; Dingmann Colleen; Gaul Lawrence; Fralick Kelly; Christians Uwe; Honigman Benjamin; Salman M D
Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m).
High altitude medicine & biology 2006;7(1):39-46.
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2005: Christians Uwe; Schmitz Volker; Haschke Manuel
Functional interactions between P-glycoprotein and CYP3A in drug metabolism.
Expert opinion on drug metabolism & toxicology 2005;1(4):641-54.
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2005: Serkova Natalie J; Christians Uwe
Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood.
Therapeutic drug monitoring 2005;27(6):733-7.
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2005: Zhang Yan Ling; Bendrick-Peart Jamie; Strom Tobin; Haschke Manuel; Christians Uwe
Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples.
Therapeutic drug monitoring 2005;27(6):770-8.
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2005: Zhou Huiyu; Zhang Yanling; Biggs Danielle L; Manning Mark C; Randolph Theodore W; Christians Uwe; Hybertson Brooks M; Ng Ka-yun
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):288-99.
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2005: Frassetto Lynda; Baluom Muhammad; Jacobsen Wolfgang; Christians Uwe; Roland Michelle E; Stock Peter G; Carlson Laurie; Benet Leslie Z
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Transplantation 2005;80(1):13-7.
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2005: Tissot van Patot Martha C; Leadbetter Guy; Keyes Linda E; Bendrick-Peart Jamie; Beckey Virginia E; Christians Uwe; Hackett Peter
Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(5):1626-9.
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2005: Lam Tuan T; Hausen Bernard; Hook Laurie; Lau Macy; Higgins John; Christians Uwe; Jacobsen Wolfgang; Baluom Muhammad; Duthaler Rudolf; Katopodis Andreas; Chavez Gilda; Cozzi Emanuele; Harrison Richard; Schuurman Henk-Jan; Borie Dominique; Morris Randall E
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.
Xenotransplantation 2005;12(1):20-9.
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2004: Egge-Jacobsen Wolfgang; Unger Matthias; Niemann Claus U; Baluom Muhammad; Hirai Sumiko; Benet Leslie Z; Christians Uwe
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
Therapeutic drug monitoring 2004;26(5):546-62.
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2004: Christians Uwe; Gottschalk Sven; Miljus Jelena; Hainz Carsten; Benet Leslie Z; Leibfritz Dieter; Serkova Natalie
Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.
British journal of pharmacology 2004;143(3):388-96.
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2004: Christians Uwe
Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A.
Therapeutic drug monitoring 2004;26(2):104-6.
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2004: Serkova Natalie J; Christians Uwe; Benet Leslie Z
Biochemical mechanisms of cyclosporine neurotoxicity.
Molecular interventions 2004;4(2):97-107.
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2004: Bîrsan Tudor; Dambrin Camille; Marsh Kennan C; Jacobsen Wolfgang; Djuric Stevan W; Mollison Karl W; Christians Uwe; Carter George W; Morris Randall E
Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(3):145-50.
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2004: Cummins Carolyn L; Jacobsen Wolfgang; Christians Uwe; Benet Leslie Z
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
The Journal of pharmacology and experimental therapeutics 2004;308(1):143-55.
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2003: Serkova Natalie; Christians Uwe
Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides.
Current opinion in investigational drugs (London, England : 2000) 2003;4(11):1287-96.
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2003: Wischmeyer Paul E; Jayakar David; Williams Ursula; Singleton Kristen D; Riehm Jacob; Bacha Emile A; Jeevanandam Valluvan; Christians Uwe; Serkova Natalie
Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
JPEN. Journal of parenteral and enteral nutrition 2003;27(6):396-403.
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2003: Wiseman A C; Kam I; Christians U; Jani A; Bak T; Wachs M; Chan L
Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience.
Transplantation proceedings 2003;35(3 Suppl):122S-124S.
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2003: Dambrin Camille; Klupp Jochen; Bîrsan Tudor; Luna Jorge; Suzuki Takeshi; Lam Tuan; Stähr Peter; Hausen Bernard; Christians Uwe; Fitzgerald Peter; Berry Gerald; Morris Randall
Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts.
Circulation 2003;107(18):2369-74.
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2003: Frassetto Lynda; Thai Thien; Aggarwal Anjana M; Bucher Patricia; Jacobsen Wolfgang; Christians Uwe; Benet Leslie Z; Floren Leslie C
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
Drug metabolism and pharmacokinetics 2003;18(2):114-20.
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2002: Niemann Claus U; Stabernack Caroline; Serkova Natalie; Jacobsen Wolfgang; Christians Uwe; Eger Edmond I
Cyclosporine can increase isoflurane MAC.
Anesthesia and analgesia 2002;95(4):930-4, table of contents.
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2002: Kirchner G; Mueller L; Winkler M; Loss M; Roechte F; Deters M; Christians U; Kaever V; Klempnauer J; Sewing K; Manns M
Long-term pharmacokinetics of the metabolites of everolimus and cyclosporine in renal transplant recipients.
Transplantation proceedings 2002;34(6):2233-4.
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2002: Niemann Claus U; Saeed Maythem; Akbari Haydar; Jacobsen Wolfgang; Benet Leslie Z; Christians Uwe; Serkova Natalie
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1123-8.
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2002: Cho Cheong-Weon; Liu Yang; Cobb Wesley N; Henthorn Thomas K; Lillehei Kevin; Christians Uwe; Ng Ka-Yun
Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells.
Pharmaceutical research 2002;19(8):1123-9.
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2002: Serkova Natalie; Donohoe Paul; Gottschalk Sven; Hainz Carsten; Niemann Claus U; Bickler Philip E; Litt Lawrence; Benet Leslie Z; Leibfritz Dieter; Christians Uwe
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(3):342-52.
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2002: Christians Uwe; Jacobsen Wolfgang; Benet Leslie Z; Lampen Alfonso
Mechanisms of clinically relevant drug interactions associated with tacrolimus.
Clinical pharmacokinetics 2002;41(11):813-51.
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2001: Liu Y; Lillehei K; Cobb W N; Christians U; Ng K Y
Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation.
Biochemical and biophysical research communications 2001;289(1):62-8.
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2001: Hausen B; Klupp J; Christians U; Higgins J P; Baumgartner R E; Hook L E; Friedrich S; Celnicker A; Morris R E
Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys.
Transplantation 2001;72(6):1128-37.
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2001: Serkova N; Jacobsen W; Niemann C U; Litt L; Benet L Z; Leibfritz D; Christians U
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
British journal of pharmacology 2001;133(6):875-85.
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2001: Kuhn B; Jacobsen W; Christians U; Benet L Z; Kollman P A
Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.
Journal of medicinal chemistry 2001;44(12):2027-34.
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2001: van Gelder T; Klupp J; Barten M J; Christians U; Morris R E
Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid.
Therapeutic drug monitoring 2001;23(2):119-28.
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2001: Kirchner G I; Jacobsen W; Deters M; Christians U; Nashan B; Winkler M; Vidal C; Kaever V; Sewing K; Manns M P
Fast quantification method for sirolimus and its major metabolites.
Transplantation proceedings 2001;33(1-2):1091-2.
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2001: Jacobsen W; Serkova N; Hausen B; Morris R E; Benet L Z; Christians U
Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.
Transplantation proceedings 2001;33(1-2):514-5.
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2001: Mancinelli L M; Frassetto L; Floren L C; Dressler D; Carrier S; Bekersky I; Benet L Z; Christians U
The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
Clinical pharmacology and therapeutics 2001;69(1):24-31.
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2000: Braun F; Christians U; Laabs S; Elias K; Shipkova M; Schütz E; Ringe B
An ex vivo model to study the intestinal biotransformation of immunosuppressives.
Transplantation proceedings 2000;32(7):2536.
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2000: Braun F; Christians U; Laabs S; Elias K; Shipkova M; Schütz E; Ringe B
An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs.
Transplantation proceedings 2000;32(7):1999.
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2000: Jacobsen W; Kuhn B; Soldner A; Kirchner G; Sewing K F; Kollman P A; Benet L Z; Christians U
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1369-78.
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2000: Jacobsen W; Christians U; Benet L Z
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1343-51.
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2000: Christians U; Jacobsen W; Serkova N; Benet L Z; Vidal C; Sewing K F; Manns M P; Kirchner G I
Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):41-53.
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2000: Ikonen T S; Gummert J F; Hayase M; Honda Y; Hausen B; Christians U; Berry G J; Yock P G; Morris R E
Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates.
Transplantation 2000;70(6):969-75.
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2000: Serkova N; Hausen B; Berry G J; Jacobsen W; Benet L Z; Morris R E; Christians U
Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
The Journal of pharmacology and experimental therapeutics 2000;294(1):323-32.
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2000: Christians U; First M R; Benet L Z
Recommendations for bioequivalence testing of cyclosporine generics revisited.
Therapeutic drug monitoring 2000;22(3):330-45.
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2000: Hausen B; Boeke K; Berry G J; Christians U; Schüler W; Morris R E
Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD.
The Annals of thoracic surgery 2000;69(3):904-9.
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2000: Soldner A; Benet L Z; Mutschler E; Christians U
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
British journal of pharmacology 2000;129(6):1235-43.
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2000: Serkova N; Litt L; Leibfritz D; Hausen B; Morris R E; James T L; Benet L Z; Christians U
The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
British journal of pharmacology 2000;129(3):485-92.
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2000: Hausen B; Gummert J; Berry G J; Christians U; Serkova N; Ikonen T; Hook L; Legay F; Schuler W; Schreier M H; Morris R E
Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin.
Transplantation 2000;69(4):488-96.
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2000: Hausen B; Ikonen T; Briffa N; Berry G J; Christians U; Robbins R C; Hook L; Serkova N; Benet L Z; Schuler W; Morris R E
Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.
Transplantation 2000;69(1):76-86.
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2000: Ikonen T S; Gummert J F; Serkova N; Hayase M; Honda Y; Kobayase Y; Hausen B; Yock P G; Christians U; Morris R E
Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening.
Transplant international : official journal of the European Society for Organ Transplantation 2000;13 Suppl 1():S314-20.
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1999: Jacobsen W; Kirchner G; Hallensleben K; Mancinelli L; Deters M; Hackbarth I; Baner K; Benet L Z; Sewing K F; Christians U
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
The Journal of pharmacology and experimental therapeutics 1999;291(1):131-9.
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1999: Hausen B; Berry G J; Dagum P; Ikonen T; Christians U; Briffa N; Hook L; Morris R E
The histology of subcutaneously implanted donor bronchial rings correlates with rejection scores of lung allografts in a primate lung transplant model.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(7):714-24.
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1999: Christians U
Generic immunosuppressants: the European perspective.
Transplantation proceedings 1999;31(3A Suppl):19S-22S.
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1999: Serkova N; Litt L; James T L; Sadée W; Leibfritz D; Benet L Z; Christians U
Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.
The Journal of pharmacology and experimental therapeutics 1999;289(2):800-6.
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1999: Soldner A; Christians U; Susanto M; Wacher V J; Silverman J A; Benet L Z
Grapefruit juice activates P-glycoprotein-mediated drug transport.
Pharmaceutical research 1999;16(4):478-85.
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1999: Hausen B; Boeke K; Berry G J; Segarra I; Benet L Z; Christians U; Morris R E
Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.
Transplantation 1999;67(7):956-62.
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1999: Hausen B; Boeke K; Berry G J; Segarra I T; Christians U; Morris R E
Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(2):150-9.
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1999: Hausen B; Boeke K; Berry G J; Gummert J F; Christians U; Morris R E
Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model.
Transplantation 1999;67(3):354-9.
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1999: Jacobsen W; Kirchner G; Hallensleben K; Mancinelli L; Deters M; Hackbarth I; Benet L Z; Sewing K F; Christians U
Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):173-9.
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1999: Gummert J F; Christians U; Barten M; Silva H; Morris R E
High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma.
Journal of chromatography. B, Biomedical sciences and applications 1999;721(2):321-6.
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1999: Kirchner G I; Vidal C; Jacobsen W; Franzke A; Hallensleben K; Christians U; Sewing K F
Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 1999;721(2):285-94.
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1998: Segarra I; Brazelton T R; Guterman N; Hausen B; Jacobsen W; Morris R E; Benet L Z; Christians U
Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
Journal of chromatography. B, Biomedical sciences and applications 1998;720(1-2):179-87.
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1998: Christians U; Jacobsen W; Floren L C
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?
Pharmacology & therapeutics 1998;80(1):1-34.
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1998: Lampen A; Zhang Y; Hackbarth I; Benet L Z; Sewing K F; Christians U
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1104-12.
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1997: Serkova N; Christians U; Flögel U; Pfeuffer J; Leibfritz D
Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy.
Chemical research in toxicology 1997;10(12):1359-63.
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1997: Braun F; Schütz E; Christians U; Lorf T; Schiffmann J H; Armstrong V W; Schröter W; Sewing K F; Oellerich M; Ringe B
Pitfalls in monitoring tacrolimus (FK 506).
Therapeutic drug monitoring 1997;19(6):628-31.
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1997: Olbricht C; Wanner C; Eisenhauer T; Kliem V; Doll R; Boddaert M; O'Grady P; Krekler M; Mangold B; Christians U
Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses.
Clinical pharmacology and therapeutics 1997;62(3):311-21.
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1996: Kliem V; Wanner C; Eisenhauer T; Olbricht C J; Doll R; Boddaert M; O'Grady P; Krekler M; Mangold B; Christians U
Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine.
Transplantation proceedings 1996;28(6):3126-8.
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1996: Winkler M; Christians U; Baumann J; Gonschior A K; Wonigeit K; Pichlmayr R
Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation.
Therapeutic drug monitoring 1996;18(6):640-6.
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1996: Serkova N; Brand A; Christians U; Leibfritz D
Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy.
Biochimica et biophysica acta 1996;1314(1-2):93-104.
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1996: Streit F; Christians U; Schiebel H M; Meyer A; Sewing K F
Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(11):1272-8.
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1996: Winkler M; Haller G; Oldhafer K; Bechstein W O; Kattner A; Maibücher A; Färber L; Ringe B; Christians U; Neuhaus P; Pichlmayr R
A new oral formulation of cyclosporine for early oral immunosuppressive therapy in liver transplant recipients.
Transplantation 1996;62(8):1063-8.
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1996: Gonschior A K; Christians U; Winkler M; Linck A; Baumann J; Sewing K F
Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients.
Clinical chemistry 1996;42(9):1426-32.
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1996: Streit F; Christians U; Schiebel H M; Napoli K L; Ernst L; Linck A; Kahan B D; Sewing K F
Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry.
Clinical chemistry 1996;42(9):1417-25.
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1996: Pethig K; Ruhparwar A; Korn A; Christians U; Wahlers T
Conversion from Sandimmune to Neoral in stable heart transplant recipients.
Transplantation proceedings 1996;28(4):2287-9.
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1996: Pethig K; Geiger M; Korn A; Grote M; Christians U; Wahlers T
Follow-up after conversion to Neoral in stable heart transplant recipients.
Transplantation proceedings 1996;28(4):2282-4.
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1996: Christians U; Bleck J S; Lampen A; Bader A; Thiesemann C; Kliem V; Repp H; Westhoff-Bleck M; Manns M; Sewing K F
Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?
Transplantation proceedings 1996;28(4):2159-61.
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1996: Bleck J S; Thiesemann C; Kliem V; Christians U; Hecker H; Repp H; Frei U; Westhoff-Bleck M; Manns M; Sewing K F
Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients.
British journal of clinical pharmacology 1996;41(6):551-6.
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1996: Lampen A; Christians U; Gonschior A K; Bader A; Hackbarth I; von Engelhardt W; Sewing K F
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber.
British journal of pharmacology 1996;117(8):1730-4.
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1996: Bader A; Knop E; Böker K H; Crome O; Frühauf N; Gonschior A K; Christians U; Esselmann H; Pichlmayr R; Sewing K F
Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(4):461-73.
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1996: Christians U; Schmidt G; Bader A; Lampen A; Schottmann R; Linck A; Sewing K F
Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes.
British journal of clinical pharmacology 1996;41(3):187-90.
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1996: Lampen A; Christians U; Bader A; Hackbarth I; Sewing K F
Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine.
Pharmacology 1996;52(3):159-68.
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1995: Lampen A; Christians U; Guengerich F P; Watkins P B; Kolars J C; Bader A; Gonschior A K; Dralle H; Hackbarth I; Sewing K F
Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1315-24.
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1995: Christians U; Sewing K F
Alternative cyclosporine metabolic pathways and toxicity.
Clinical biochemistry 1995;28(6):547-59.
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1995: Gonschior A K; Christians U; Winkler M; Schiebel H M; Linck A; Sewing K F
Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay.
Therapeutic drug monitoring 1995;17(5):504-10.
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1995: Christians U; Kohlhaw K; Sürig T; Bader A; Schottmann R; Linck A; Ringe B; Sewing K F
Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients.
Therapeutic drug monitoring 1995;17(5):487-98.
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1995: Bader A; Knop E; Frühauf N; Crome O; Böker K; Christians U; Oldhafer K; Ringe B; Pichlmayr R; Sewing K F
Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver.
Artificial organs 1995;19(9):941-50.
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1995: Winkler M; Wonigeit K; Undre N; Ringe B; Oldhafer K; Christians U; Pichlmayr R
Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring.
Transplantation proceedings 1995;27(1):822-5.
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1995: Bader A; Reimer P; Knop E; Böker K; Christians U; Weissleder R; Sewing K F
An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents.
Magnetic resonance imaging 1995;13(7):991-1002.
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1994: Gonschior A K; Christians U; Braun F; Winkler M; Linck A; Baumann J; Sewing K F
Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA).
British journal of clinical pharmacology 1994;38(6):567-71.
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1994: Christians U; Kohlhaw K; Esselmann H; Sürig T; Luy M; Kaltefleiter M; Beyrau R; Linck A; Ringe B; Oellerich M
The yin and yang of lidocaine and cyclosporine metabolism in liver graft recipients.
Transplantation proceedings 1994;26(5):2827-8.
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1994: Kohlhaw K; Christians U; Sürig T; Lamesch P; Hauss J; Sewing K F; Pichlmayr R
Cyclosporine and bilirubin metabolites compete for the hepatic excretory system.
Transplantation proceedings 1994;26(5):2798-9.
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1994: Bader A; Zech K; Crome O; Christians U; Ringe B; Pichlmayr R; Sewing K F
Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(7):623-33.
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1994: Winkler M; Christians U; Stoll K; Baumann J; Pichlmayr R
Comparison of different assays for the quantitation of FK 506 levels in blood or plasma.
Therapeutic drug monitoring 1994;16(3):281-6.
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1993: Christians U; Spiekermann K; Bader A; Schottmann R; Linck A; Wonigeit K; Sewing K F; Link H
Cyclosporine metabolite pattern in blood from patients with acute GVHD after BMT.
Bone marrow transplantation 1993;12(1):27-33.
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1993: Hoof T; Demmer A; Christians U; Tümmler B
Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin.
European journal of pharmacology 1993;246(1):53-8.
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1993: Christians U; Sewing K F
Cyclosporin metabolism in transplant patients.
Pharmacology & therapeutics 1993;57(2-3):291-345.
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1992: Christians U; Braun F; Schmidt M; Kosian N; Schiebel H M; Ernst L; Winkler M; Kruse C; Linck A; Sewing K F
Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients.
Clinical chemistry 1992;38(10):2025-32.
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1992: Sattler M; Guengerich F P; Yun C H; Christians U; Sewing K F
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):753-61.
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1992: Radeke H H; Christians U; Sewing K F; Resch K
The synergistic immunosuppressive potential of cyclosporin metabolite combinations.
International journal of immunopharmacology 1992;14(4):595-604.
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1992: Christians U; Sattler M; Schiebel H M; Kruse C; Radeke H H; Linck A; Sewing K F
Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):186-91.
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1991: Christians U; Braun F; Sattler M; Almeidal V M; Linck A; Sewing K F
Interactions of FK 506 and cyclosporine metabolism.
Transplantation proceedings 1991;23(6):2794-6.
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1991: Christians U; Braun F; Kosian N; Schmidt M; Schiebel H M; Ernst L; Kruse C; Winkler M; Holze I; Linck A
High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients.
Transplantation proceedings 1991;23(6):2741-4.
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1991: Christians U; Strohmeyer S; Kownatzki R; Schiebel H M; Bleck J; Kohlhaw K; Schottmann R; Sewing K F
Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(9):1199-210.
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1991: Christians U; Strohmeyer S; Kownatzki R; Schiebel H M; Bleck J; Greipel J; Kohlhaw K; Schottmann R; Sewing K F
Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile--isolation of 12 new cyclosporine metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(9):1185-98.
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1991: Radeke H H; Christians U; Bleck J S; Sewing K F; Resch K
Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells.
Kidney international 1991;39(6):1255-66.
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1991: Christians U; Radeke H H; Kownatzki R; Schiebel H M; Schottmann R; Sewing K F
Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations.
Clinical biochemistry 1991;24(3):271-5.
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1991: Schlitt H J; Christians U; Bleck J; Kohlhaw K; Ringe B; Bunzendahl H; Sewing K F; Wonigeit K; Pichlmayr R
Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction.
Transplant international : official journal of the European Society for Organ Transplantation 1991;4(1):38-44.
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1991: Christians U; Kruse C; Kownatzki R; Schiebel H M; Schwinzer R; Sattler M; Schottmann R; Linck A; Almeida V M; Braun F
Measurement of FK 506 by HPLC and isolation and characterization of its metabolites.
Transplantation proceedings 1991;23(1 Pt 2):940-1.
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1991: Christians U; Kohlhaw K; Budniak J; Bleck J S; Schottmann R; Schlitt H J; Almeida V M; Deters M; Wonigeit K; Pichlmayr R
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection.
European journal of clinical pharmacology 1991;41(4):291-6.
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1991: Christians U; Kohlhaw K; Budniak J; Bleck J S; Schottmann R; Schlitt H J; Almeida V M; Deters M; Wonigeit K; Pichlmayr R
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity.
European journal of clinical pharmacology 1991;41(4):285-90.
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1991: Bleck J S; Schlitt H J; Christians U; Schottmann R; Thiesemann C; Strohmeyer S; Kohlhaw K; Wonigeit K; Pichlmayr R; Sewing K F
Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function.
European journal of clinical pharmacology 1991;40(6):565-9.
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1990: Sewing K F; Christians U; Kohlhaw K; Radeke H; Strohmeyer S; Kownatzki R; Budniak J; Schottmann R; Bleck J S; Almeida V M
Biologic activity of cyclosporine metabolites.
Transplantation proceedings 1990;22(3):1129-34.
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1990: Bleck J S; Nashan B; Christians U; Schottmann R; Wonigeit K; Sewing K F
Single dose pharmacokinetics of ciclosporin and its main metabolites after oral ciclosporin as oily solution or capsule.
Arzneimittel-Forschung 1990;40(1):62-4.
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1989: Bleck J S; Schlitt H J; Christians U; Thiesemann C; Strohmeyer S; Schottmann R; Kohlhaw K; Wonigeit K; Sewing K F
Urinary excretion of ciclosporin and 17 of its metabolites in renal allograft recipients.
Pharmacology 1989;39(3):160-4.
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1988: Nashan B; Bleck J; Wonigeit K; Vogt P; Christians U; Sewing K F; Beveridge T; Pichlmayr R
Effect of the application form of cyclosporine on blood levels: comparison of oral solution and capsules.
Transplantation proceedings 1988;20(2 Suppl 2):637-9.
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1988: Christians U; Schlitt H J; Bleck J S; Schiebel H M; Kownatzki R; Maurer G; Strohmeyer S S; Schottmann R; Wonigeit K; Pichlmayr R
Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography.
Transplantation proceedings 1988;20(2 Suppl 2):609-13.
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1988: Sewing K F; Christians U; Bleck J S; Strohmeyer S; Beil W; Kohlhaw K; Wonigeit K
[Drug monitoring of cyclosporin by using high-performance liquid chromatography]
Deutsche medizinische Wochenschrift (1946) 1988;113(8):311-4.
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1988: Christians U; Zimmer K O; Wonigeit K; Maurer G; Sewing K F
Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile, and urine.
Clinical chemistry 1988;34(1):34-9.
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1988: Sewing K F; Christians U; Bleck J S; Schottmann R; Strohmeyer S S
Measurement and disposition of ciclosporin and its metabolites.
Bibliotheca cardiologica 1988;(43):63-72.
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1987: Schlitt H J; Christians U; Wonigeit K; Sewing K F; Pichlmayr R
Immunosuppressive activity of cyclosporine metabolites in vitro.
Transplantation proceedings 1987;19(5):4248-51.
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