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Uwe Christians

Research Profile

Chemicals & Drugs

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TOP 3
Jacek Klepacki; Volker Schmitz; Nina Brunner; Uwe Christians; Jelena Klawitter; Jost Klawitter
Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma.
Rahul Bohra; Jelena Klawitter; Jost Klawitter; Jacek Klepacki; Joshua M Thurman; Uwe Christians
Proteomics and metabolomics in renal transplantation-quo vadis?
Margaret E Macy; Aru Narendren; Katherine Rolla; Tanya Trippett; James Whitlock; Robert J Arceci; Rochelle Bagatell; Jessica Boklan; Uwe Christians; Tracey Duncan; Lia Gore; Cynthia Herzog; Stephen P Hunger; S Percy Ivy
A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors.

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2013: Jacek Klepacki; Volker Schmitz; Nina Brunner; Uwe Christians; Jelena Klawitter; Jost Klawitter
Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma.
Clinica chimica acta; international journal of clinical chemistry 2013;421():91-7.
2013: Rahul Bohra; Jelena Klawitter; Jost Klawitter; Jacek Klepacki; Joshua M Thurman; Uwe Christians
Proteomics and metabolomics in renal transplantation-quo vadis?
Transplant international : official journal of the European Society for Organ Transplantation 2013;26(3):225-41.
2013: Margaret E Macy; Aru Narendren; Katherine Rolla; Tanya Trippett; James Whitlock; Robert J Arceci; Rochelle Bagatell; Jessica Boklan; Uwe Christians; Tracey Duncan; Lia Gore; Cynthia Herzog; Stephen P Hunger; S Percy Ivy
A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors.
Pediatric blood & cancer 2013;60(2):230-6.
2013: Hamid Razzaghi; Stephanie A Santorico; Touraj Shokati; Anna Tempczyk-Russell; Uwe Christians; Kurt Haubold; Mair E A Churchill
Genetic and structure-function studies of missense mutations in human endothelial lipase.
PloS one 2013;8(3):e55716.
2013: Jelena Klawitter; Jost Klawitter; Dieter Leibfritz; Brian D Lowes; Erika Agardi; Uwe Christians; Kyler Corby; Tamas Seres
Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.
Cardiovascular research 2013;97(1):66-76.
2012: Jost Klawitter; Jost Klawitter; Dieter Leibfritz; Volker Schmitz; Joshua M Thurman; Jamie Bendrick-Peart; Nina Brunner; Kyler Corby; Amanda Crunk; Charles L Edelstein; Uwe Christians
Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism.
Journal of proteome research 2012;11(11):5135-44.
2012: Christina L Aquilante; Uwe Christians; Elizabeth B Daily; Keith L Hoffman; Charles W Hopley; Jennifer J Kiser; Lisa A Kosmiski; Julie A Predhomme; Bjorn Schniedewind; Peter L Anderson; Maha S Sidhom
Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.
Journal of clinical pharmacology 2012;52(11):1725-38.
2012: Jacek Klepacki; Bjorn Schniedewind; Touraj Shokati; Jelena Klawitter; Jamie Bendrick-Peart; Uwe Christians; Svenja Heischmann; Jost Klawitter
A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;883-884():113-9.
2012: Stefanie Niederlechner; Christine Baird; Uwe Christians; Alyssa R Kallweit; Jost Klawitter; Paul E Wischmeyer
Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury.
PloS one 2012;7(11):e50185.
2012: Rahul Bohra; Nina Brunner; Uwe Christians; Jost Klawitter; Ryan Lawrence; Volker Schmitz; Björn Schniedewind; Wenzel Schöning; Touraj Shokati; Maria Fernanda Arbelaez; Jost Klawitter
Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat.
PloS one 2012;7(10):e48063.
2011: Jelena Klawitter; Jost Klawitter; Linda Quattrochi; Emma Shtivelman; Mary Tagliaferri; Isaac Cohen; Kyler Corby; Sylvia Fong; Jennifer Gurshtein; Uwe Christians
Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study.
International journal of cancer. Journal international du cancer 2011;129(12):2945-57.
2011: Tobin Strom; Keith Hoffman; Jost Klawitter; Jelena Klawitter; Hans-Martin Schiebel; Touraj Shokati; Uwe Christians
Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.
Journal of mass spectrometry : JMS 2011;46(7):615-24.
2011: Claudia F Clavijo; Keith L Hoffman; James J Thomas; Brendan Carvalho; Larry F Chu; David R Drover; Gregory B Hammer; Uwe Christians; Jeffrey L Galinkin
A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry 2011;400(3):715-28.
2011: Miodrag C Ostojic; Zoran Perisic; Dragan Sagic; Robert Jung; Yan-Ling Zhang; Jamie Bendrick-Peart; Ronald Betts; Uwe Christians
The pharmacokinetics of Biolimus A9 after elution from the BioMatrix II stent in patients with coronary artery disease: the Stealth PK Study.
European journal of clinical pharmacology 2011;67(4):389-98.
2011: Jost Klawitter; Manuel Haschke; Touraj Shokati; Jost Klawitter; Uwe Christians
Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared.
Rapid communications in mass spectrometry : RCM 2011;25(4):463-8.
2011: Uwe Christians; Jost Klawitter; Jelena Klawitter; Nina Brunner; Volker Schmitz
Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions.
Expert opinion on drug metabolism & toxicology 2011;7(2):175-200.
2011: Sven Gottschalk; Carolyn L Cummins; Dieter Leibfritz; Uwe Christians; Leslie Z Benet; Natalie J Serkova
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
Neurotoxicology 2011;32(1):50-7.
2011: Wolfgang Steudel; Colleen Dingmann; Yan-Ling Zhang; Jamie Bendrick-Peart; Claudia Clavijo; John Shulze; Ronald Betts; Uwe Christians
Randomized, double-blind, placebo-controlled, single intravenous dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of the novel coronary smooth muscle cell proliferation inhibitor Biolimus A9 in healthy individuals.
Journal of clinical pharmacology 2011;51(1):29-39.
2010: Martin S Angst; Nicholas G Phillips; David R Drover; Martha Tingle; Jeffrey L Galinkin; Uwe Christians; Gary E Swan; Laura C Lazzeroni; J David Clark
Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2010;13(5):412-25.
2010: Jost Klawitter; Manuel Haschke; Christine Kahle; Colleen Dingmann; Jelena Klawitter; Dieter Leibfritz; Uwe Christians
Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose.
British journal of clinical pharmacology 2010;70(2):241-51.
2010: Jelena Klawitter; Sven Gottschalk; Carsten Hainz; Dieter Leibfritz; Uwe Christians; Natalie J Serkova
Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism.
Chemical research in toxicology 2010;23(3):608-19.
2010: Uwe Christians; Jelena Klawitter; Claudia F Clavijo
Bioequivalence testing of immunosuppressants: concepts and misconceptions.
Kidney international. Supplement 2010;(115):S1-7.
2010: Jost Klawitter; Jelena Klawitter; Erich Kushner; Karen Jonscher; Jamie Bendrick-Peart; Dieter Leibfritz; Uwe Christians; Volker Schmitz
Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study.
Journal of proteome research 2010;9(2):865-75.
2010: Jost Klawitter; Touraj Shokati; Vanessa Moll; Uwe Christians; Jost Klawitter
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.
Breast cancer research : BCR 2010;12(2):R16.
2009: Jost Klawitter; Yan Ling Zhang; Jost Klawitter; Nora Anderson; Natalie J Serkova; Uwe Christians
Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.
Biomedical chromatography : BMC 2009;23(12):1251-8.
2009: Claudia Clavijo; Tobin Strom; Vanessa Moll; Ronald Betts; Yan Ling Zhang; Uwe Christians; Jamie Bendrick-Peart
Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3506-14.
2009: Andriy Marusyk; Matias Casás-Selves; Curtis J Henry; Vadym Zaberezhnyy; Jelena Klawitter; Uwe Christians; James DeGregori
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
Cancer research 2009;69(18):7262-9.
2009: Jost Klawitter; Douglas J Kominsky; Jaimi L Brown; Jost Klawitter; Uwe Christians; Dieter Leibfritz; Junia V Melo; S Gail Eckhardt; Natalie J Serkova
Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells.
British journal of pharmacology 2009;158(2):588-600.
2009: Martha C Tissot van Patot; Natalie J Serkova; Manuel Haschke; Douglas J Kominsky; Robert Roach; Uwe Christians; Thomas K Henthorn; Benjamin Honigman
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
Free radical biology & medicine 2009;46(11):1551-7.
2009: J Klawitter; N Anderson; J Klawitter; Uwe Christians; Dieter Leibfritz; S Gail Eckhardt; Natalie J Serkova
Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study.
British journal of cancer 2009;100(6):923-31.
2009: Guido Filler; Jamie Bendrick-Peart; Tobin Strom; Yan Ling Zhang; Gillian Johnson; Uwe Christians
Characterization of sirolimus metabolites in pediatric solid organ transplant recipients.
Pediatric transplantation 2009;13(1):44-53.
2009: Volker Schmitz; Jost Klawitter; Jamie Bendrick-Peart; Wenzel Schoening; Gero Puhl; Manuel Haschke; Jelena Klawitter; Jeff Consoer; Christopher J Rivard; L Chan; Zung Tran; Dieter Leibfritz; Uwe Christians
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation.
Nephron. Experimental nephrology 2009;111(4):e80-91.
2009: Jost Klawitter; Jamie Bendrick-Peart; Birgit Rudolph; Virginia Beckey; Jelena Klawitter; Manuel Haschke; Christopher Rivard; L Chan; Dieter Leibfritz; Uwe Christians; Volker Schmitz
Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.
Chemical research in toxicology 2009;22(1):118-28.
2008: Miodrag Ostojic; Dragan Sagic; Robert Jung; Yan-Ling Zhang; Milan Nedeljkovic; Ljupco Mangovski; Sinisa Stojkovic; Dragan Debeljacki; Mirko Colic; Branko Beleslin; Bratislav Milosavljevic; Dejan Orlic; Dragan Topic; Nevena Karanovic; Dragica Paunovic; Uwe Christians
The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2008;72(7):901-8.
2008: René Kupfer; Leah Swanson; Sylvia Chow; Richard E Staub; Yan Ling Zhang; Isaac Cohen; Uwe Christians
Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2261-9.
2008: Claudia Clavijo; Jamie Bendrick-Peart; Yan Ling Zhang; Gillian Johnson; Antje Gasparic; Uwe Christians
An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;874(1-2):33-41.
2008: Uwe Christians; Volker Schmitz; Wenzel Schöning; Jamie Bendrick-Peart; Jelena Klawitter; Manuel Haschke; Jost Klawitter
Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges.
Therapeutic drug monitoring 2008;30(2):151-8.
2008: Guido Filler; Jamie Bendrick-Peart; Uwe Christians
Pharmacokinetics of mycophenolate mofetil and sirolimus in children.
Therapeutic drug monitoring 2008;30(2):138-42.
2008: Jost Klawitter; Christopher J Rivard; Lewis M Brown; Juan M Capasso; Nestor Almeida; Arvid B Maunsbach; Kaarina Pihakaski-Maunsbach; Tomas Berl; Dieter Leibfritz; Uwe Christians; L Chan
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity.
Nephron. Physiology 2008;109(1):p1-10.
2007: Tobin Strom; Manuel Haschke; Jared Boyd; Mark Roberts; Lili Arabshahi; Peter Marbach; Uwe Christians
Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus.
Therapeutic drug monitoring 2007;29(6):743-9.
2007: Tobin Strom; Manuel Haschke; Yan Ling Zhang; Jamie Bendrick-Peart; Jared Boyd; Mark Roberts; Lili Arabshahi; Peter Marbach; Uwe Christians
Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients.
Therapeutic drug monitoring 2007;29(5):592-9.
2007: Sven Laudi; Saskia Trump; Volker Schmitz; James West; Ivan F McMurtry; Haitham Mutlak; Uwe Christians; Jörg Weimann; Udo Kaisers; Wolfgang Steudel
Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.
American journal of physiology. Lung cellular and molecular physiology 2007;293(3):L630-8.
2007: Sven Laudi; Wolfgang Steudel; Karen Jonscher; Wenzel Schöning; Björn Schniedewind; Udo Kaisers; Uwe Christians; Saskia Trump
Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension.
Proteomics 2007;7(14):2469-78.
2007: Jost Klawitter; Volker Schmitz; Jelena Klawitter; Dieter Leibfritz; Uwe Christians
Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS.
Analytical biochemistry 2007;365(2):230-9.
2007: Klaus Olaf Boernsen; Wolfgang Egge-Jacobsen; Bruno Inverardi; Tobin Strom; Frank Streit; Hans-Martin Schiebel; Leslie Z Benet; Uwe Christians
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
Journal of mass spectrometry : JMS 2007;42(6):793-802.
2007: Theodore W Perry; Uwe Christians; James F Trotter; Jamie Bendrick-Peart
Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients.
Clinical transplantation 2007;21(3):413-6.
2007: Sven Laudi; Jörg Weimann; Manuel Haschke; Saskia Trump; Volker Schmitz; Uwe Christians; U Kaisers; Wolfgang Steudel
Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58(1):19-32.
2007: Manuel Haschke; Yan Ling Zhang; Christine Kahle; Jost Klawitter; Magdalena Korecka; Leslie M Shaw; Uwe Christians
HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma.
Clinical chemistry 2007;53(3):489-97.
2007: Ka-yun Ng; Huiyu Zhou; Yan Ling Zhang; Brooks M Hybertson; Theodore Randolph; Uwe Christians
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):188-98.
2006: Uwe Christians; Tobin Strom; Yan Ling Zhang; Wolfgang Steudel; Volker Schmitz; Saskia Trump; Manuel Haschke
Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics.
Therapeutic drug monitoring 2006;28(1):39-44.
2006: Volker Schmitz; Jost Klawitter; Jamie Bendrick-Peart; Manuel Haschke; Virginia E Beckey; Sven Laudi; Ulf Neumann; Wenzel Schoening; Peter Neuhaus; Uwe Christians; Gero Puhl
Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2006;38(4):388-98.
2006: Martha C Tissot Van Patot; Ashley E Hill; Colleen Dingmann; Lawrence Gaul; Kelly Fralick; Uwe Christians; Benjamin Honigman; M D Salman
Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m).
High altitude medicine & biology 2006;7(1):39-46.
2005: Uwe Christians; Volker Schmitz; Manuel Haschke
Functional interactions between P-glycoprotein and CYP3A in drug metabolism.
Expert opinion on drug metabolism & toxicology 2005;1(4):641-54.
2005: Natalie J Serkova; Uwe Christians
Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood.
Therapeutic drug monitoring 2005;27(6):733-7.
2005: Yan Ling Zhang; Jamie Bendrick-Peart; Tobin Strom; Manuel Haschke; Uwe Christians
Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples.
Therapeutic drug monitoring 2005;27(6):770-8.
2005: Huiyu Zhou; Yanling Zhang; Danielle L Biggs; Mark C Manning; Theodore W Randolph; Uwe Christians; Brooks M Hybertson; Ka-yun Ng
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):288-99.
2005: Lynda Frassetto; Muhammad Baluom; Wolfgang Jacobsen; Uwe Christians; Michelle E Roland; Peter G Stock; Laurie Carlson; Leslie Z Benet
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Transplantation 2005;80(1):13-7.
2005: Martha C Tissot van Patot; Guy Leadbetter; Linda E Keyes; Jamie Bendrick-Peart; Virginia E Beckey; Uwe Christians; Peter H Hackett
Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(5):1626-9.
2005: Tuan T Lam; Bernard Hausen; Laurie Hook; Macy Lau; John Higgins; Uwe Christians; Wolfgang Jacobsen; Muhammad Baluom; Rudolf O Duthaler; Andreas G Katopodis; Gilberto Chavez; Emanuele Cozzi; Richard Harrison; Henk-Jan Schuurman; Dominic C Borie; randall morris
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.
Xenotransplantation 2005;12(1):20-9.
2004: Wolfgang Egge-Jacobsen; Matthias Unger; Claus U Niemann; Muhammad Baluom; Sumiko Hirai; Leslie Z Benet; Uwe Christians
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
Therapeutic drug monitoring 2004;26(5):546-62.
2004: Uwe Christians; Sven Gottschalk; Jelena Miljus; Carsten Hainz; Leslie Z Benet; Dieter Leibfritz; Natalie J Serkova
Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.
British journal of pharmacology 2004;143(3):388-96.
2004: Uwe Christians
Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A.
Therapeutic drug monitoring 2004;26(2):104-6.
2004: Natalie J Serkova; Uwe Christians; Leslie Z Benet
Biochemical mechanisms of cyclosporine neurotoxicity.
Molecular interventions 2004;4(2):97-107.
2004: Tudor Bîrsan; Camille Dambrin; Kennan Marsh; Wolfgang Jacobsen; Stevan W Djuric; Karl W Mollison; Uwe Christians; George W Carter; randall morris
Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(3):145-50.
2004: Carolyn L Cummins; Wolfgang Jacobsen; Uwe Christians; Leslie Z Benet
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
The Journal of pharmacology and experimental therapeutics 2004;308(1):143-55.
2003: Natalie J Serkova; Uwe Christians
Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides.
Current opinion in investigational drugs (London, England : 2000) 2003;4(11):1287-96.
2003: Paul E Wischmeyer; David Jayakar; Ursula Williams; Kristen D Singleton; Jacob Riehm; Emile A Bacha; Valluvan Jeevanandam; Uwe Christians; Natalie J Serkova
Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
JPEN. Journal of parenteral and enteral nutrition 2003;27(6):396-403.
2003: Camille Dambrin; Jochen Klupp; Tudor Bîrsan; Jorge Luna; Takeshi Suzuki; Tuan Lam; Peter Stähr; Bernard Hausen; Uwe Christians; Peter Fitzgerald; Gerald Berry; Randall Morris
Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts.
Circulation 2003;107(18):2369-74.
2003: Alexander C Wiseman; Igal Kam; Uwe Christians; Alkesh Jani; Thomas Bak; Michael Wachs; L Chan
Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience.
Transplantation proceedings 2003;35(3 Suppl):122S-124S.
2003: Lynda Frassetto; Thien Thai; Anjana M Aggarwal; Patricia Bucher; Wolfgang Jacobsen; Uwe Christians; Leslie Z Benet; Leslie Carstensen Floren
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
Drug metabolism and pharmacokinetics 2003;18(2):114-20.
2002: Claus U Niemann; Caroline R Stabernack; Natalie J Serkova; Wolfgang Jacobsen; Uwe Christians; Edmond I Eger
Cyclosporine can increase isoflurane MAC.
Anesthesia and analgesia 2002;95(4):930-4, table of contents.
2002: Gabriele I Kirchner; L Mueller; M Winkler; M Loss; F Roechte; Michael Deters; Uwe Christians; Volkhard Kaever; Jürgen Klempnauer; KF Sewing; Michael P Manns
Long-term pharmacokinetics of the metabolites of everolimus and cyclosporine in renal transplant recipients.
Transplantation proceedings 2002;34(6):2233-4.
2002: Claus U Niemann; Maythem Saeed; Haydar Akbari; Wolfgang Jacobsen; Leslie Z Benet; Uwe Christians; Natalie J Serkova
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1123-8.
2002: Cheong-Weon Cho; Yang Liu; Wesley N Cobb; Thomas K Henthorn; Kevin O Lillehei; Uwe Christians; Ka-yun Ng
Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells.
Pharmaceutical research 2002;19(8):1123-9.
2002: Natalie J Serkova; Paul H Donohoe; Sven Gottschalk; Carsten Hainz; Claus U Niemann; Philip E Bickler; Lawrence Litt; Leslie Z Benet; Dieter Leibfritz; Uwe Christians
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(3):342-52.
2002: Uwe Christians; Wolfgang Jacobsen; Leslie Z Benet; Alfonso Lampen
Mechanisms of clinically relevant drug interactions associated with tacrolimus.
Clinical pharmacokinetics 2002;41(11):813-51.
2001: Yang Liu; Kevin O Lillehei; Wesley N Cobb; Uwe Christians; Ka-yun Ng
Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation.
Biochemical and biophysical research communications 2001;289(1):62-8.
2001: Bernard Hausen; Jochen Klupp; Uwe Christians; John P Higgins; R E Baumgartner; Laurie Hook; S Friedrich; A Celnicker; randall morris
Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys.
Transplantation 2001;72(6):1128-37.
2001: Natalie J Serkova; Wolfgang Jacobsen; Claus U Niemann; Lawrence Litt; Leslie Z Benet; Dieter Leibfritz; Uwe Christians
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
British journal of pharmacology 2001;133(6):875-85.
2001: Bernd Kuhn; Wolfgang Jacobsen; Uwe Christians; Leslie Z Benet; Peter A Kollman
Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.
Journal of medicinal chemistry 2001;44(12):2027-34.
2001: Teun van Gelder; Jochen Klupp; Markus J Barten; Uwe Christians; randall morris
Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid.
Therapeutic drug monitoring 2001;23(2):119-28.
2001: Gabriele I Kirchner; Wolfgang Jacobsen; Michael Deters; Uwe Christians; Björn Nashan; M Winkler; Christian Vidal; Volkhard Kaever; KF Sewing; Michael P Manns
Fast quantification method for sirolimus and its major metabolites.
Transplantation proceedings 2001;33(1-2):1091-2.
2001: Wolfgang Jacobsen; Natalie J Serkova; Bernard Hausen; randall morris; Leslie Z Benet; Uwe Christians
Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.
Transplantation proceedings 2001;33(1-2):514-5.
2001: LM Mancinelli; Lynda Frassetto; Leslie Carstensen Floren; D Dressler; S Carrier; Ihor Bekersky; Leslie Z Benet; Uwe Christians
The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
Clinical pharmacology and therapeutics 2001;69(1):24-31.
2000: Felix Braun; Uwe Christians; SO Laabs; K Elias; Maria Shipkova; Ekkehard Schütz; Burckhardt Ringe
An ex vivo model to study the intestinal biotransformation of immunosuppressives.
Transplantation proceedings 2000;32(7):2536.
2000: Felix Braun; Uwe Christians; SO Laabs; K Elias; Maria Shipkova; Ekkehard Schütz; Burckhardt Ringe
An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs.
Transplantation proceedings 2000;32(7):1999.
2000: Wolfgang Jacobsen; Bernd Kuhn; A Soldner; Gabriele I Kirchner; KF Sewing; Peter A Kollman; Leslie Z Benet; Uwe Christians
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1369-78.
2000: Wolfgang Jacobsen; Uwe Christians; Leslie Z Benet
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1343-51.
2000: Uwe Christians; Wolfgang Jacobsen; Natalie J Serkova; Leslie Z Benet; Christian Vidal; KF Sewing; M P Manns; Gabriele I Kirchner
Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):41-53.
2000: Tuija Ikonen; Jan F Gummert; Motoya Hayase; Yasuhiro Honda; Bernard Hausen; Uwe Christians; Gerald J Berry; Paul G Yock; randall morris
Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates.
Transplantation 2000;70(6):969-75.
2000: Natalie J Serkova; Bernard Hausen; G J Berry; Wolfgang Jacobsen; Leslie Z Benet; randall morris; Uwe Christians
Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
The Journal of pharmacology and experimental therapeutics 2000;294(1):323-32.
2000: Uwe Christians; M R First; Leslie Z Benet
Recommendations for bioequivalence testing of cyclosporine generics revisited.
Therapeutic drug monitoring 2000;22(3):330-45.
2000: Bernard Hausen; Katrin Boeke; Gerald J Berry; Uwe Christians; W Schüler; randall morris
Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD.
The Annals of thoracic surgery 2000;69(3):904-9.
2000: A Soldner; Leslie Z Benet; Ernst Mutschler; Uwe Christians
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
British journal of pharmacology 2000;129(6):1235-43.
2000: Bernard Hausen; Jan F Gummert; Gerald J Berry; Uwe Christians; Natalie J Serkova; Tuija Ikonen; Laurie Hook; F Legay; Walter Schuler; MH Schreier; randall morris
Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin.
Transplantation 2000;69(4):488-96.
2000: Natalie J Serkova; Lawrence Litt; Dieter Leibfritz; Bernard Hausen; R E Morris; Tom L James; Leslie Z Benet; Uwe Christians
The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
British journal of pharmacology 2000;129(3):485-92.
2000: Bernard Hausen; Tuija Ikonen; Norman P Briffa; Gerald J Berry; Uwe Christians; Robert C Robbins; Laurie Hook; Natalie J Serkova; Leslie Z Benet; Walter Schuler; randall morris
Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.
Transplantation 2000;69(1):76-86.
2000: Tuija Ikonen; Jan F Gummert; Natalie J Serkova; Motoya Hayase; Y Honda; Y Kobayase; Bernard Hausen; P G Yock; Uwe Christians; randall morris
Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening.
Transplant international : official journal of the European Society for Organ Transplantation 2000;13 Suppl 1():S314-20.
1999: Wolfgang Jacobsen; Gabriele I Kirchner; K Hallensleben; LM Mancinelli; Michael Deters; I Hackbarth; K Baner; Leslie Z Benet; KF Sewing; Uwe Christians
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
The Journal of pharmacology and experimental therapeutics 1999;291(1):131-9.
1999: Bernard Hausen; Gerald J Berry; P Dagum; Tuija Ikonen; Uwe Christians; Norman P Briffa; Laurie Hook; randall morris
The histology of subcutaneously implanted donor bronchial rings correlates with rejection scores of lung allografts in a primate lung transplant model.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(7):714-24.
1999: Uwe Christians
Generic immunosuppressants: the European perspective.
Transplantation proceedings 1999;31(3A Suppl):19S-22S.
1999: Natalie J Serkova; Lawrence Litt; Tom L James; Wolfgang Sadée; Dieter Leibfritz; Leslie Z Benet; Uwe Christians
Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.
The Journal of pharmacology and experimental therapeutics 1999;289(2):800-6.
1999: Bernard Hausen; Katrin Boeke; Gerald J Berry; Ignacio Segarra; Leslie Z Benet; Uwe Christians; randall morris
Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.
Transplantation 1999;67(7):956-62.
1999: A Soldner; Uwe Christians; Miki Susanto; Vincent J Wacher; Jeffrey A Silverman; Leslie Z Benet
Grapefruit juice activates P-glycoprotein-mediated drug transport.
Pharmaceutical research 1999;16(4):478-85.
1999: Bernard Hausen; Katrin Boeke; Gerald J Berry; Jan F Gummert; Uwe Christians; randall morris
Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model.
Transplantation 1999;67(3):354-9.
1999: Bernard Hausen; Katrin Boeke; Gerald J Berry; Ignacio Segarra; Uwe Christians; randall morris
Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1999;18(2):150-9.
1999: Wolfgang Jacobsen; Gabriele I Kirchner; K Hallensleben; LM Mancinelli; Michael Deters; I Hackbarth; Leslie Z Benet; KF Sewing; Uwe Christians
Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):173-9.
1999: Jan F Gummert; Uwe Christians; Markus J Barten; H Silva; randall morris
High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma.
Journal of chromatography. B, Biomedical sciences and applications 1999;721(2):321-6.
1999: Gabriele I Kirchner; Christian Vidal; Wolfgang Jacobsen; Anke Franzke; K Hallensleben; Uwe Christians; KF Sewing
Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 1999;721(2):285-94.
1998: Ignacio Segarra; T R Brazelton; N Guterman; Bernard Hausen; Wolfgang Jacobsen; randall morris; Leslie Z Benet; Uwe Christians
Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
Journal of chromatography. B, Biomedical sciences and applications 1998;720(1-2):179-87.
1998: Uwe Christians; Wolfgang Jacobsen; Leslie Carstensen Floren
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?
Pharmacology & therapeutics 1998;80(1):1-34.
1998: Alfonso Lampen; Y Zhang; I Hackbarth; Leslie Z Benet; KF Sewing; Uwe Christians
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1104-12.
1997: Natalie J Serkova; Uwe Christians; U Flögel; J Pfeuffer; Dieter Leibfritz
Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy.
Chemical research in toxicology 1997;10(12):1359-63.
1997: F Braun; Ekkehard Schütz; Uwe Christians; T Lorf; holger schiffmann; Victor W Armstrong; W Schröter; KF Sewing; Michael Oellerich; B Ringe
Pitfalls in monitoring tacrolimus (FK 506).
Therapeutic drug monitoring 1997;19(6):628-31.
1997: Christoph J Olbricht; C Wanner; T Eisenhauer; Volker Kliem; R Doll; M Boddaert; P O'Grady; M Krekler; B Mangold; Uwe Christians
Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses.
Clinical pharmacology and therapeutics 1997;62(3):311-21.
1996: Volker Kliem; C Wanner; T Eisenhauer; C J Olbricht; R Doll; M Boddaert; P O'Grady; M Krekler; B Mangold; Uwe Christians
Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine.
Transplantation proceedings 1996;28(6):3126-8.
1996: Michael Winkler; Uwe Christians; J Baumann; A K Gonschior; Kurt Wonigeit; Rudolf Pichlmayr
Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation.
Therapeutic drug monitoring 1996;18(6):640-6.
1996: Natalie J Serkova; A Brand; Uwe Christians; Dieter Leibfritz
Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy.
Biochimica et biophysica acta 1996;1314(1-2):93-104.
1996: F Streit; Uwe Christians; H M Schiebel; A Meyer; KF Sewing
Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(11):1272-8.
1996: Michael Winkler; GW Haller; Karl J Oldhafer; Wolf Bechstein; A Kattner; A Maibücher; L Färber; B Ringe; Uwe Christians; Peter Neuhaus; Rudolf Pichlmayr
A new oral formulation of cyclosporine for early oral immunosuppressive therapy in liver transplant recipients.
Transplantation 1996;62(8):1063-8.
1996: A K Gonschior; Uwe Christians; Michael Winkler; A Linck; J Baumann; KF Sewing
Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients.
Clinical chemistry 1996;42(9):1426-32.
1996: F Streit; Uwe Christians; H M Schiebel; K L Napoli; L Ernst; A Linck; B D Kahan; KF Sewing
Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry.
Clinical chemistry 1996;42(9):1417-25.
1996: Klaus Pethig; A Ruhparwar; A Korn; Uwe Christians; Thorsten Wahlers
Conversion from Sandimmune to Neoral in stable heart transplant recipients.
Transplantation proceedings 1996;28(4):2287-9.
1996: Klaus Pethig; M Geiger; A Korn; M Grote; Uwe Christians; Thorsten Wahlers
Follow-up after conversion to Neoral in stable heart transplant recipients.
Transplantation proceedings 1996;28(4):2282-4.
1996: Uwe Christians; Jörg S Bleck; Alfonso Lampen; Augustinus Bader; C Thiesemann; Volker Kliem; H Repp; Mechthild Westhoff-Bleck; Michael P Manns; KF Sewing
Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?
Transplantation proceedings 1996;28(4):2159-61.
1996: Jörg S Bleck; C Thiesemann; Volker Kliem; Uwe Christians; H Hecker; H Repp; U Frei; Mechthild Westhoff-Bleck; Michael P Manns; KF Sewing
Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients.
British journal of clinical pharmacology 1996;41(6):551-6.
1996: Alfonso Lampen; Uwe Christians; A K Gonschior; Augustinus Bader; I Hackbarth; Wolfgang Von Engelhardt; KF Sewing
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber.
British journal of pharmacology 1996;117(8):1730-4.
1996: Augustinus Bader; E Knop; Klaus H W Böker; O Crome; Nils R Frühauf; A K Gonschior; Uwe Christians; H Esselmann; Rudolf Pichlmayr; KF Sewing
Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(4):461-73.
1996: Uwe Christians; G Schmidt; Augustinus Bader; Alfonso Lampen; R Schottmann; A Linck; KF Sewing
Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes.
British journal of clinical pharmacology 1996;41(3):187-90.
1996: Alfonso Lampen; Uwe Christians; Augustinus Bader; I Hackbarth; KF Sewing
Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine.
Pharmacology 1996;52(3):159-68.
1995: Alfonso Lampen; Uwe Christians; F P Guengerich; Paul B Watkins; Joseph C Kolars; Augustinus Bader; A K Gonschior; H Dralle; I Hackbarth; KF Sewing
Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1315-24.
1995: Uwe Christians; KF Sewing
Alternative cyclosporine metabolic pathways and toxicity.
Clinical biochemistry 1995;28(6):547-59.
1995: A K Gonschior; Uwe Christians; Michael Winkler; H M Schiebel; A Linck; KF Sewing
Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay.
Therapeutic drug monitoring 1995;17(5):504-10.
1995: Uwe Christians; Kay Kohlhaw; T Sürig; Augustinus Bader; R Schottmann; A Linck; B Ringe; KF Sewing
Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients.
Therapeutic drug monitoring 1995;17(5):487-98.
1995: Augustinus Bader; E Knop; Nils R Frühauf; O Crome; Klaus H W Böker; Uwe Christians; Karl J Oldhafer; B Ringe; Rudolf Pichlmayr; KF Sewing
Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver.
Artificial organs 1995;19(9):941-50.
1995: Michael Winkler; Kurt Wonigeit; N Undre; B Ringe; Karl J Oldhafer; Uwe Christians; Rudolf Pichlmayr
Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring.
Transplantation proceedings 1995;27(1):822-5.
1995: Augustinus Bader; P Reimer; E Knop; Klaus H W Böker; Uwe Christians; R Weissleder; KF Sewing
An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents.
Magnetic resonance imaging 1995;13(7):991-1002.
1994: A K Gonschior; Uwe Christians; F Braun; Michael Winkler; A Linck; J Baumann; KF Sewing
Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA).
British journal of clinical pharmacology 1994;38(6):567-71.
1994: Uwe Christians; Kay Kohlhaw; H Esselmann; T Sürig; M Luy; M Kaltefleiter; R Beyrau; A Linck; B Ringe; Michael Oellerich
The yin and yang of lidocaine and cyclosporine metabolism in liver graft recipients.
Transplantation proceedings 1994;26(5):2827-8.
1994: Kay Kohlhaw; Uwe Christians; T Sürig; Peter Lamesch; Johann Hauss; KF Sewing; R Pichlmayr
Cyclosporine and bilirubin metabolites compete for the hepatic excretory system.
Transplantation proceedings 1994;26(5):2798-9.
1994: Augustinus Bader; K Zech; O Crome; Uwe Christians; B Ringe; Rudolf Pichlmayr; KF Sewing
Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(7):623-33.
1994: Michael Winkler; Uwe Christians; K Stoll; J Baumann; Rudolf Pichlmayr
Comparison of different assays for the quantitation of FK 506 levels in blood or plasma.
Therapeutic drug monitoring 1994;16(3):281-6.
1993: Uwe Christians; Karsten Spiekermann; Augustinus Bader; R Schottmann; A Linck; Kurt Wonigeit; KF Sewing; H Link
Cyclosporine metabolite pattern in blood from patients with acute GVHD after BMT.
Bone marrow transplantation 1993;12(1):27-33.
1993: T Hoof; A Demmer; Uwe Christians; Burkhard Tümmler
Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin.
European journal of pharmacology 1993;246(1):53-8.
1993: Uwe Christians; K F Sewing
Cyclosporin metabolism in transplant patients.
Pharmacology & therapeutics 1993;57(2-3):291-345.
1992: Uwe Christians; F Braun; M Schmidt; N Kosian; H M Schiebel; L Ernst; Michael Winkler; C Kruse; A Linck; KF Sewing
Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients.
Clinical chemistry 1992;38(10):2025-32.
1992: M Sattler; F P Guengerich; C H Yun; Uwe Christians; KF Sewing
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):753-61.
1992: Heinfried Radeke; Uwe Christians; K F Sewing; Klaus Resch
The synergistic immunosuppressive potential of cyclosporin metabolite combinations.
International journal of immunopharmacology 1992;14(4):595-604.
1992: Uwe Christians; M Sattler; H M Schiebel; C Kruse; Heinfried Radeke; A Linck; KF Sewing
Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):186-91.
1991: Uwe Christians; F Braun; M Sattler; V M Almeidal; A Linck; KF Sewing
Interactions of FK 506 and cyclosporine metabolism.
Transplantation proceedings 1991;23(6):2794-6.
1991: Uwe Christians; F Braun; N Kosian; M Schmidt; H M Schiebel; L Ernst; C Kruse; Michael Winkler; I Holze; A Linck
High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients.
Transplantation proceedings 1991;23(6):2741-4.
1991: Uwe Christians; S Strohmeyer; R Kownatzki; H M Schiebel; Jörg S Bleck; Kay Kohlhaw; R Schottmann; KF Sewing
Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(9):1199-210.
1991: Uwe Christians; S Strohmeyer; R Kownatzki; H M Schiebel; Jörg S Bleck; J Greipel; Kay Kohlhaw; R Schottmann; KF Sewing
Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile--isolation of 12 new cyclosporine metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(9):1185-98.
1991: Heinfried Radeke; Uwe Christians; Jörg S Bleck; KF Sewing; Klaus Resch
Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells.
Kidney international 1991;39(6):1255-66.
1991: Uwe Christians; Heinfried Radeke; R Kownatzki; H M Schiebel; R Schottmann; KF Sewing
Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations.
Clinical biochemistry 1991;24(3):271-5.
1991: Hans J Schlitt; Uwe Christians; Jörg S Bleck; Kay Kohlhaw; B Ringe; Hartwig Bunzendahl; KF Sewing; Kurt Wonigeit; Rudolf Pichlmayr
Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction.
Transplant international : official journal of the European Society for Organ Transplantation 1991;4(1):38-44.
1991: Uwe Christians; C Kruse; R Kownatzki; H M Schiebel; Reinhard Schwinzer; M Sattler; R Schottmann; A Linck; V M Almeida; F Braun
Measurement of FK 506 by HPLC and isolation and characterization of its metabolites.
Transplantation proceedings 1991;23(1 Pt 2):940-1.
1991: Uwe Christians; Kay Kohlhaw; J Budniak; Jörg S Bleck; R Schottmann; Hans J Schlitt; V M Almeida; Michael Deters; Kurt Wonigeit; Rudolf Pichlmayr
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection.
European journal of clinical pharmacology 1991;41(4):291-6.
1991: Uwe Christians; Kay Kohlhaw; J Budniak; Jörg S Bleck; R Schottmann; Hans J Schlitt; V M Almeida; Michael Deters; Kurt Wonigeit; Rudolf Pichlmayr
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity.
European journal of clinical pharmacology 1991;41(4):285-90.
1991: Jörg S Bleck; Hans J Schlitt; Uwe Christians; R Schottmann; C Thiesemann; S Strohmeyer; Kay Kohlhaw; Kurt Wonigeit; Rudolf Pichlmayr; KF Sewing
Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function.
European journal of clinical pharmacology 1991;40(6):565-9.
1990: KF Sewing; Uwe Christians; Kay Kohlhaw; Heinfried Radeke; S Strohmeyer; R Kownatzki; J Budniak; R Schottmann; Jörg S Bleck; V M Almeida
Biologic activity of cyclosporine metabolites.
Transplantation proceedings 1990;22(3):1129-34.
1990: Jörg S Bleck; B Nashan; Uwe Christians; R Schottmann; Kurt Wonigeit; KF Sewing
Single dose pharmacokinetics of ciclosporin and its main metabolites after oral ciclosporin as oily solution or capsule.
Arzneimittel-Forschung 1990;40(1):62-4.
1989: Jörg S Bleck; Hans J Schlitt; Uwe Christians; C Thiesemann; S Strohmeyer; R Schottmann; Kay Kohlhaw; Kurt Wonigeit; KF Sewing
Urinary excretion of ciclosporin and 17 of its metabolites in renal allograft recipients.
Pharmacology 1989;39(3):160-4.
1988: B Nashan; Jörg S Bleck; Kurt Wonigeit; P Vogt; Uwe Christians; KF Sewing; T Beveridge; Rudolf Pichlmayr
Effect of the application form of cyclosporine on blood levels: comparison of oral solution and capsules.
Transplantation proceedings 1988;20(2 Suppl 2):637-9.
1988: Uwe Christians; Hans J Schlitt; Jörg S Bleck; H M Schiebel; R Kownatzki; G Maurer; S S Strohmeyer; R Schottmann; Kurt Wonigeit; Rudolf Pichlmayr
Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography.
Transplantation proceedings 1988;20(2 Suppl 2):609-13.
1988: KF Sewing; Uwe Christians; Jörg S Bleck; S Strohmeyer; Winfried Beil; Kay Kohlhaw; Kurt Wonigeit
[Drug monitoring of cyclosporin by using high-performance liquid chromatography].
Deutsche medizinische Wochenschrift (1946) 1988;113(8):311-4.
1988: Uwe Christians; K O Zimmer; Kurt Wonigeit; G Maurer; KF Sewing
Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile, and urine.
Clinical chemistry 1988;34(1):34-9.
1988: KF Sewing; Uwe Christians; Jörg S Bleck; R Schottmann; S S Strohmeyer
Measurement and disposition of ciclosporin and its metabolites.
Bibliotheca cardiologica 1988;(43):63-72.
1987: Hans J Schlitt; Uwe Christians; Kurt Wonigeit; KF Sewing; Rudolf Pichlmayr
Immunosuppressive activity of cyclosporine metabolites in vitro.
Transplantation proceedings 1987;19(5):4248-51.