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Holger Christiansen

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Jessica Theissen; Marc Boensch; Rüdiger Spitz; David Betts; Sabine Stegmaier; Holger Christiansen; Felix Niggli; Freimut Schilling; Manfred Schwab; Thorsten Simon; Frank Westermann; Frank Berthold; Barbara Hero
Heterogeneity of the MYCN oncogene in neuroblastoma.
Johannes H Schulte; Sebastian Horn; Stefanie Schlierf; Alexander Schramm; Lukas Heukamp; Holger Christiansen; Reinhard Buettner; Bernd Berwanger; Angelika Eggert
MicroRNAs in the pathogenesis of neuroblastoma.
Tobias Otto; Sebastian Horn; Markus Brockmann; Ursula Eilers; Lars Schüttrumpf; Nikita Popov; Anna Marie Kenney; Johannes H Schulte; Roderick L Beijersbergen; Holger Christiansen; Bernd Berwanger; Martin Eilers
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.

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All Publications

2009: Jessica Theissen; Marc Boensch; Rüdiger Spitz; David Betts; Sabine Stegmaier; Holger Christiansen; Felix Niggli; Freimut Schilling; Manfred Schwab; Thorsten Simon; Frank Westermann; Frank Berthold; Barbara Hero
Heterogeneity of the MYCN oncogene in neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):2085-90.
2009: Johannes H Schulte; Sebastian Horn; Stefanie Schlierf; Alexander Schramm; Lukas Heukamp; Holger Christiansen; Reinhard Buettner; Bernd Berwanger; Angelika Eggert
MicroRNAs in the pathogenesis of neuroblastoma.
Cancer letters 2009;274(1):10-5.
2009: Tobias Otto; Sebastian Horn; Markus Brockmann; Ursula Eilers; Lars Schüttrumpf; Nikita Popov; Anna Marie Kenney; Johannes H Schulte; Roderick L Beijersbergen; Holger Christiansen; Bernd Berwanger; Martin Eilers
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.
Cancer cell 2009;15(1):67-78.
2008: Johannes H Schulte; Sebastian Horn; Tobias Otto; Birgit Samans; Lukas Heukamp; Ursula-Christa Eilers; Michael Krause; Kathy Astrahantseff; Ludger Klein-Hitpass; Reinhard Buettner; Alexander Schramm; Holger Christiansen; Martin Eilers; Angelika Eggert; Bernd Berwanger
MYCN regulates oncogenic MicroRNAs in neuroblastoma.
International journal of cancer. Journal international du cancer 2008;122(3):699-704.
2006: Axel Weber; Sven Starke; Eckhard Bergmann; Holger Christiansen
The coamplification pattern of the MYCN amplicon is an invariable attribute of most MYCN-amplified human neuroblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7316-21.
2006: Simone Fulda; Christopher Poremba; Bernd Berwanger; Sabine Häcker; Martin Eilers; Holger Christiansen; Barbara Hero; Klaus-Michael Debatin
Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma.
Cancer research 2006;66(20):10016-23.
2006: Katrin Nowak; Kornelius Kerl; Daniel Fehr; Christoph Kramps; Christine Gessner; Katrin Killmer; Birgit Samans; Bernd Berwanger; Holger Christiansen; Werner Lutz
BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas.
Nucleic acids research 2006;34(6):1745-54.
2005: Alexander Schramm; Johannes H Schulte; Ludger Klein-Hitpass; Werner Havers; Hauke Sieverts; Bernd Berwanger; Holger Christiansen; Patrick Warnat; Benedikt Brors; Jürgen Eils; Roland Eils; Angelika Eggert
Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling.
Oncogene 2005;24(53):7902-12.
2005: Jo Vandesompele; Baudis Michael; Katleen De Preter; Nadine Van Roy; Peter F Ambros; Nick Bown; Christian Brinkschmidt; Holger Christiansen; Valérie Combaret; Maria Lastowska; James Nicholson; Anne O'Meara; Dominique Plantaz; Raymond L Stallings; Bénédicte Brichard; Caroline Van den Broecke; Sylvia De Bie; Anne De Paepe; Geneviève Laureys; Frank Speleman
Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(10):2280-99.
2005: Alexander Schramm; Volker von Schuetz; Holger Christiansen; Werner Havers; Maria Papoutsi; Jörg Wilting; Lothar Schweigerer
High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome.
Oncogene 2005;24(4):680-7.
2004: Axel Weber; Patricia Imisch; Eckhard Bergmann; Holger Christiansen
Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(13):2681-90.
2003: Axel Weber; Christine Huesken; Eckhard Bergmann; Wieland Kiess; Nina M Christiansen; Holger Christiansen
Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5683-92.
2002: Bernd Berwanger; Oliver Hartmann; Eckhard Bergmann; Sandra Bernard; Dirk Nielsen; Michael Krause; Ali Kartal; Daniel Flynn; Ruprecht Wiedemeyer; Manfred Schwab; Helmut Schäfer; Holger Christiansen; Martin Eilers
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
Cancer cell 2002;2(5):377-86.
2001: Christopher Poremba; B Hero; H G Goertz; Christina Scheel; Daniel Wai; Karl-Ludwig Schaefer; Holger Christiansen; F Berthold; Herbert Juergens; Werner Boecker; Barbara Dockhorn-Dworniczak
Traditional and emerging molecular markers in neuroblastoma prognosis: the good, the bad and the ugly.
Klinische Pädiatrie 2001;213(4):186-90.
2001: Eckhard Bergmann; Michael Wanzel; Axel Weber; I Shin; Holger Christiansen; Martin Eilers
Expression of P27(KIP1) is prognostic and independent of MYCN amplification in human neuroblastoma.
International journal of cancer. Journal international du cancer 2001;95(3):176-83.
2001: Jo Vandesompele; Frank Speleman; Nadine Van Roy; Geneviève Laureys; C Brinskchmidt; Holger Christiansen; F Lampert; Maria Lastowska; Nick Bown; A Pearson; JC Nicholson; F Ross; Valérie Combaret; O Delattre; Burt Feuerstein; Dominique Plantaz
Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: how many genetic subgroups are there?
Medical and pediatric oncology 2001;36(1):5-10.
2001: Christian Brinkschmidt; Holger Christiansen; Hans-Joachim Terpe; Ronald Simon; Fritz H Lampert; Werner Boecker; Barbara Dockhorn-Dworniczak
Distal chromosome 17 gains in neuroblastomas detected by comparative genomic hybridization (CGH) are associated with a poor clinical outcome.
Medical and pediatric oncology 2001;36(1):11-3.
2000: Christopher Poremba; B Hero; Bernhard Heine; Christina Scheel; Karl-Ludwig Schaefer; Holger Christiansen; F Berthold; Sören Kneif; Harald Stein; Herbert Juergens; Werner Boecker; Barbara Dockhorn-Dworniczak
Telomerase is a strong indicator for assessing the proneness to progression in neuroblastomas.
Medical and pediatric oncology 2000;35(6):651-5.
2000: Christopher Poremba; Christina Scheel; B Hero; Holger Christiansen; Karl-Ludwig Schaefer; J i Nakayama; F Berthold; Herbert Juergens; Werner Boecker; Barbara Dockhorn-Dworniczak
Telomerase activity and telomerase subunits gene expression patterns in neuroblastoma: a molecular and immunohistochemical study establishing prognostic tools for fresh-frozen and paraffin-embedded tissues.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(13):2582-92.
1999: M Theobald; Holger Christiansen; A Schmidt; B Melekian; N Wolkewitz; N M Christiansen; Christian Brinkschmidt; F Berthold; Fritz H Lampert
Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma.
Genes, chromosomes & cancer 1999;26(1):40-6.
1999: Nick Bown; Simon J Cotterill; Maria Lastowska; S O'Neill; Andrew D J Pearson; Dominique Plantaz; Mounira Meddeb; Gisèle Danglot; Christian Brinkschmidt; Holger Christiansen; Geneviève Laureys; Frank Speleman; James Nicholson; Alain BERNHEIM; D R Betts; Jo Vandesompele; Nadine Van Roy
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
The New England journal of medicine 1999;340(25):1954-61.
1999: Christopher Poremba; Holger Willenbring; B Hero; Holger Christiansen; Karl-Ludwig Schäfer; Christian Brinkschmidt; Heribert Jürgens; Werner Böcker; Barbara Dockhorn-Dworniczak
Telomerase activity distinguishes between neuroblastomas with good and poor prognosis.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(6):715-21.
1998: Rudolf Erttmann; T Tafese; Frank Berthold; R Kerbl; J Mann; L Parker; Freimut H Schilling; Peter F Ambros; Holger Christiansen; M Favrot; Hartmut Kabisch; Barbara Hero; T Philip
10 years' neuroblastoma screening in Europe: preliminary results of a clinical and biological review from the Study Group for Evaluation of Neuroblastoma Screening in Europe (SENSE).
European journal of cancer (Oxford, England : 1990) 1998;34(9):1391-7.
1998: Christian Brinkschmidt; Christopher Poremba; Holger Christiansen; Ronald Simon; Karl-Ludwig Schäfer; Hans-Joachim Terpe; Fritz H Lampert; Werner Boecker; Barbara Dockhorn-Dworniczak
Comparative genomic hybridization and telomerase activity analysis identify two biologically different groups of 4s neuroblastomas.
British journal of cancer 1998;77(12):2223-9.
1997: Rani E George; R Kenyon; AG McGuckin; N Kohl; P Kogner; Holger Christiansen; Andrew D J Pearson; John Lunec
Analysis of candidate gene co-amplification with MYCN in neuroblastoma.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2037-42.
1997: Wieland Kiess; G Koepf; Holger Christiansen; Werner F Blum
Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation.
Regulatory peptides 1997;72(1):19-29.
1997: Barbara Dockhorn-Dworniczak; Karl-Ludwig Schäfer; S Blasius; Holger Christiansen; E Koscielniak; J Ritter; Winfried Winkelmann; Heribert Jürgens; Werner Böcker
Assessment of molecular genetic detection of chromosome translocations in the differential diagnosis of pediatric sarcomas.
Klinische Pädiatrie 1997;209(4):156-64.
1997: Christian Brinkschmidt; Holger Christiansen; Hans-Joachim Terpe; Ronald Simon; Werner Boecker; Fritz H Lampert; S Stoerkel
Comparative genomic hybridization (CGH) analysis of neuroblastomas--an important methodological approach in paediatric tumour pathology.
The Journal of pathology 1997;181(4):394-400.
1997: Fritz H Lampert; Holger Christiansen; F Berner; Hans-Joachim Terpe; F Berthold
Disseminated neuroblastomas under 1 year of age: cell biology and prognosis.
Journal of neuro-oncology 1997;31(1-2):181-4.
1996: Christian Brinkschmidt; Holger Christiansen; Hans-Joachim Terpe; Ronald Simon; Fritz H Lampert; Werner Böcker; S Störkel
[Synopsis of unbalanced chromosome aberrations in neuroblastoma by comparative genomic hybridization].
Der Pathologe 1996;17(5):368-73.
1996: Frank Berthold; Barbara Hero; H Breu; Holger Christiansen; R Erttmann; A Gnekow; F Herrmann; Thomas Klingebiel; Fritz H Lampert; S Müller-Weihrich; Peter Weinel
The recurrence patterns of stages I, II and III neuroblastoma: experience with 77 relapsing patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(2):183-7.
1995: Holger Christiansen; Hans-Joachim Terpe; M Gonzales; S Wenderhold; Frank Berthold; Fritz H Lampert
[Expression of CD44-standard in 182 primary neuroblastomas].
Klinische Pädiatrie 1995;207(4):219-21.
1995: Hans-Joachim Terpe; Holger Christiansen; M Gonzalez; Frank Berthold; Fritz H Lampert
Differentiation and prognosis of neuroblastoma in correlation to the expression of CD44s.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):549-52.
1995: Holger Christiansen; K Sahin; Frank Berthold; Barbara Hero; Hans-Joachim Terpe; Fritz H Lampert
Comparison of DNA aneuploidy, chromosome 1 abnormalities, MYCN amplification and CD44 expression as prognostic factors in neuroblastoma.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):541-4.
1994: Hans-Joachim Terpe; Holger Christiansen; Frank Berthold; M Gonzalez; M Altmannsberger; A Schulz; Fritz H Lampert
Applied Sciences: Absence of CD44-standard in human neuroblastoma correlates with histological dedifferentiation, N-myc amplification and reduced survival probability.
Cell death and differentiation 1994;1(2):123-8.
1994: Holger Christiansen; O Delattre; S Fuchs; M Theobald; N M Christiansen; Frank Berthold; Fritz H Lampert
Loss of the putative tumor suppressor-gene locus 1p36 as investigated by a PCR-assay and N-myc amplification in 48 neuroblastomas: results of the German Neuroblastoma Study Group.
Progress in clinical and biological research 1994;385():19-25.
1992: Holger Christiansen; J Schestag; N M Christiansen; K H Grzeschik; Fritz H Lampert
Clinical impact of chromosome 1 aberrations in neuroblastoma: a metaphase and interphase cytogenetic study.
Genes, chromosomes & cancer 1992;5(2):141-9.
1991: Holger Christiansen; J Schestag; W Bielke; B Schütz; G Rust; R Engel; E Beniers; N M Christiansen; Fritz H Lampert
Chromosome 1 interphase-cytogenetics in 32 primary neuroblastomas of different clinical stages.
Progress in clinical and biological research 1991;366():99-105.
1990: Holger Christiansen; N M Christiansen; F Wagner; M Altmannsberger; Fritz H Lampert
Neuroblastoma: inverse relationship between expression of N-myc and NGF-r.
Oncogene 1990;5(3):437-40.
1989: Holger Christiansen; Fritz H Lampert
[Tumor cytogenetics and prognosis in neuroblastoma].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde 1989;137(10):666-71.
1988: Holger Christiansen; Fritz H Lampert
Tumour karyotype discriminates between good and bad prognostic outcome in neuroblastoma.
British journal of cancer 1988;57(1):121-6.
1988: L Longo; Holger Christiansen; N M Christiansen; P Cornaglia-Ferraris; Fritz H Lampert
N-myc amplification at chromosome band 1p32 in neuroblastoma cells as investigated by in situ hybridization.
Journal of cancer research and clinical oncology 1988;114(6):636-40.
1987: Fritz H Lampert; J Harbott; Holger Christiansen
[Specific chromosome aberrations in leukemias and tumors in childhood].
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde 1987;135(12):811-8.