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Lene Christiansen

Research Profile

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Denmark

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Physiology

Genes & Molecular Sequences

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Twins

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Polymerase Chain Reaction

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TOP 3
Marianne Nygaard; Stefan Schreiber; Mette Soerensen; Qihua Tan; Kaare Christensen; Friederike Flachsbart; Jonas Mengel-From; Almut Nebel; Lene Christiansen
AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
Rune Lindahl-Jacobsen; Jonas Mengel-From; Almut Nebel; Qihua Tan; Kaare Christensen; Lene Christiansen
Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

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All Publications

2013: Marianne Nygaard; Stefan Schreiber; Mette Soerensen; Qihua Tan; Kaare Christensen; Friederike Flachsbart; Jonas Mengel-From; Almut Nebel; Lene Christiansen
AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
European journal of human genetics : EJHG 2013;21(5):574-7.
2013: Rune Lindahl-Jacobsen; Jonas Mengel-From; Almut Nebel; Qihua Tan; Kaare Christensen; Lene Christiansen
Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
The journals of gerontology. Series A, Biological sciences and medical sciences 2013;68(4):389-94.
2013: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Age (Dordrecht, Netherlands) 2013;35(2):487-500.
2013: Axel Skytthe; Qihua Tan; James W Vaupel; Paul Bingley; Frans L Bødker; Lene Christiansen; Jacob v B Hjelmborg; Niels V Holm; Lars Hvidberg; Kirsten Ohm Kyvik; Matt McGue; Morten M F Nielsen; Inge Petersen; Kaare Christensen
The Danish Twin Registry: linking surveys, national registers, and biological information.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2013;16(1):104-11.
2012: Serena Dato; Vincenzo Lagani; Alberto Montesanto; Giuseppe Passarino; Mette Soerensen; Kaare Christensen; Lene Christiansen
UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.
Mechanisms of ageing and development 2012;133(8):530-7.
2012: Rudolf P Talens; Gonneke Willemsen; Dorret I Boomsma; Kaare Christensen; Lene Christiansen; Dennis Kremer; Hein Putter; P Eline Slagboom; H Eka D Suchiman; Bas Heijmans
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.
Aging cell 2012;11(4):694-703.
2012: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Experimental gerontology 2012;47(5):379-87.
2012: Mette Soerensen; Tinna Stevnsner; Qihua Tan; Mikael Thinggaard; Karen Andersen-Ranberg; Abraham Aviv; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Jacob v B Hjelmborg; Masayuki Kimura; Marianne Nygaard; Lene Christiansen
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.
Aging cell 2012;11(2):223-7.
2012: Helle R Andersen; Lene Christiansen; Christine Dalgård; Tina K Jensen; Katharina M Main; Katsuyuki Murata; Christine Nellemann; Niels E Skakkebaek; Christine Wohlfahrt-Veje; Philippe Grandjean
Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age.
PloS one 2012;7(5):e36830.
2011: Charlotte Brasch-Andersen; Kim Brøsen; Lene Christiansen; Malik U Møller; Marit Otto; Mikael Thinggaard; Søren H Sindrup
A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C).
European journal of clinical pharmacology 2011;67(11):1131-7.
2011: Jonas Mengel-From; Kaare Christensen; Matt McGue; Lene Christiansen
Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.
Neurobiology of aging 2011;32(3):554.e7-11.
2010: Mette Soerensen; Serena Dato; Kaare Christensen; Matt McGue; Tinna Stevnsner; Vilhelm A Bohr; Lene Christiansen
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.
Aging cell 2010;9(6):1010-7.
2010: Almuth Caliebe; Rabea Kleindorp; Hélène Blanché; Lene Christiansen; Annibale Alessandro Puca; I Maeve or Maeve Rea; Eline Slagboom; Friederike Flachsbart; Kaare Christensen; Gerald Rimbach; Stefan Schreiber; Almut Nebel
No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis.
Ageing research reviews 2010;9(3):238-44.
2010: Ann L Hasselbalch; Lars Angquist; Lene Christiansen; Berit L Heitmann; Kirsten O Kyvik; Thorkild I A Sørensen
A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake.
The Journal of nutrition 2010;140(4):831-4.
2010: Serena Dato; Karen S Krabbe; Mikael Thinggaard; Bente K Pedersen; Kaare Christensen; Helle Bruunsgaard; Lene Christiansen
Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(3):225-35.
2009: Mette Soerensen; Kaare Christensen; Tinna Stevnsner; Lene Christiansen
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.
Mechanisms of ageing and development 2009;130(5):308-14.
2007: Christine Dalgård; Lene Christiansen; Torbjørn Jonung; Michael I Mackness; Moniek P M de Maat; Mogens Hørder
No influence of increased intake of orange and blackcurrant juices and dietary amounts of vitamin E on paraoxonase-1 activity in patients with peripheral arterial disease.
European journal of nutrition 2007;46(6):354-63.
2007: Lise Bathum; Inge Petersen; Lene Christiansen; Agnieszka Konieczna; Thorkild I A Sørensen; Kirsten Ohm Kyvik
Genetic and environmental influences on plasma homocysteine: results from a Danish twin study.
Clinical chemistry 2007;53(5):971-9.
2007: Lise Bathum; Jacob von Bornemann Hjelmborg; Lene Christiansen; Matt McGue; Bernard Jeune; Kaare Christensen
Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(2):196-201.
2007: Lene Christiansen; Qihua Tan; Maria Iachina; Lise Bathum; Torben A Kruse; Matt McGue; Kaare Christensen
Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population.
Biological psychiatry 2007;61(2):223-30.
2007: Qihua Tan; Lene Christiansen; Charlotte Brasch-Andersen; Jing Hua Zhao; Shuxia Li; Torben A Kruse; Kaare Christensen
Retrospective analysis of main and interaction effects in genetic association studies of human complex traits.
BMC genetics 2007;8():70.
2006: Lene Christiansen; Charlotte Brasch-Andersen; Lise Bathum; Torben A Kruse; Kaare Christensen
A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival.
Mechanisms of ageing and development 2006;127(7):597-9.
2006: Lise Bathum; Lene Christiansen; Bernard Jeune; James W Vaupel; Matt McGue; Kaare Christensen
Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians.
Journal of the American Geriatrics Society 2006;54(4):654-8.
2006: Qihua Tan; Lene Christiansen; Lise Bathum; Shuxia Li; Torben A Kruse; Kaare Christensen
Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort.
Genetics 2006;172(3):1821-8.
2005: Qihua Tan; Lene Christiansen; Kaare Christensen; Lise Bathum; Shuxia Li; Jing Hua Zhao; Torben A Kruse
Haplotype association analysis of human disease traits using genotype data of unrelated individuals.
Genetical research 2005;86(3):223-31.
2005: Lise Bathum; Lene Christiansen; Qihua Tan; James W Vaupel; Bernard Jeune; Kaare Christensen
No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians.
European journal of human genetics : EJHG 2005;13(10):1154-8.
2005: Qihua Tan; Kaare Christensen; Lene Christiansen; Henrik Frederiksen; Lise Bathum; Jesper Dahlgaard; Torben A Kruse
Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins.
Human genetics 2005;117(2-3):267-74.
2005: Qihua Tan; Lene Christiansen; Lise Bathum; J H Zhao; W Vach; James W Vaupel; Kaare Christensen; Torben A Kruse
Haplotype effects on human survival: logistic regression models applied to unphased genotype data.
Annals of human genetics 2005;69(Pt 2):168-75.
2005: Lene Christiansen; J Brøns-Poulsen; Mogens Hørder; A Brock; Niels Erik Petersen
Expression and characterization of six clinically relevant uroporphyrinogen decarboxylase gene mutations.
Scandinavian journal of clinical and laboratory investigation 2005;65(3):227-35.
2005: J Brøns-Poulsen; Lene Christiansen; Niels Erik Petersen; Mogens Hørder; K Kristiansen
Characterization of two isoalleles and three mutations in both isoforms of purified recombinant human porphobilinogen deaminase.
Scandinavian journal of clinical and laboratory investigation 2005;65(2):93-105.
2005: Qihua Tan; Lene Christiansen; Lise Bathum; Jing Hua Zhao; Anatoliy Yashin; James W Vaupel; Kaare Christensen; Torben A Kruse
Estimating haplotype relative risks on human survival in population-based association studies.
Human heredity 2005;59(2):88-97.
2004: Lise Bathum; Corrado Fagnani; Lene Christiansen; Kaare Christensen
Heritability of biochemical kidney markers and relation to survival in the elderly--results from a Danish population-based twin study.
Clinica chimica acta; international journal of clinical chemistry 2004;349(1-2):143-50.
2004: Lene Christiansen; Lise Bathum; Henrik Frederiksen; Kaare Christensen
Paraoxonase 1 polymorphisms and survival.
European journal of human genetics : EJHG 2004;12(10):843-7.
2004: Lene Christiansen; Hans Christian Petersen; Lise Bathum; Henrik Frederiksen; Matt McGue; Kaare Christensen
The catalase -262C/T promoter polymorphism and aging phenotypes.
The journals of gerontology. Series A, Biological sciences and medical sciences 2004;59(9):B886-9.
2004: Charlotte Brasch-Andersen; Lene Christiansen; Qihua Tan; Annette Haagerup; Jørgen Vestbo; Torben A Kruse
Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers.
Human mutation 2004;24(3):208-14.
2004: Lise Bathum; Jacob von Bornemann Hjelmborg; Lene Christiansen; Jonna Skov Madsen; Axel Skytthe; Kaare Christensen
Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2004;15(8):659-64.
2004: Lene Christiansen; Lise Bathum; Karen Andersen-Ranberg; Bernard Jeune; Kaare Christensen
Modest implication of interleukin-6 promoter polymorphisms in longevity.
Mechanisms of ageing and development 2004;125(5):391-5.
2004: Nicole von Wurmb-Schwark; Thorsten Schwark; Lene Christiansen; Delia Lorenz; Manfred Oehmichen
The use of different multiplex PCRs for twin zygosity determination and its application in forensic trace analysis.
Legal medicine (Tokyo, Japan) 2004;6(2):125-30.
2004: Helle Bruunsgaard; Lene Christiansen; Agnes N Pedersen; Marianne Schroll; Torben Jørgensen; Bente Klarlund Pedersen
The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans.
Experimental gerontology 2004;39(2):255-61.
2004: Qihua Tan; Lene Christiansen; Kaare Christensen; Torben A Kruse; Lise Bathum
Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models.
European journal of epidemiology 2004;19(7):651-6.
2004: Qihua Tan; Giovanna De Benedictis; Anatoliy Yashin; Lise Bathum; Lene Christiansen; Jesper Dahlgaard; N Frizner; W Vach; James W Vaupel; Kaare Christensen; Torben A Kruse
Assessing genetic association with human survival at multi-allelic loci.
Biogerontology 2004;5(2):89-97.
2003: Qihua Tan; Lise Bathum; Lene Christiansen; Giovanna De Benedictis; Jesper Dahlgaard; N Frizner; W Vach; James W Vaupel; Anatoliy Yashin; Kaare Christensen; Torben A Kruse
Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity.
Annals of human genetics 2003;67(Pt 6):598-607.
2003: Lene Christiansen; Henrik Frederiksen; Karoline Schousboe; Axel Skytthe; Nicole von Wurmb-Schwark; Kaare Christensen; Kirsten Ohm Kyvik
Age- and sex-differences in the validity of questionnaire-based zygosity in twins.
Twin research : the official journal of the International Society for Twin Studies 2003;6(4):275-8.
2003: Anette Bygum; Lene Christiansen; Niels Erik Petersen; Mogens Hørder; Kristian Thomsen; Flemming Brandrup
Familial and sporadic porphyria cutanea tarda: clinical, biochemical and genetic features with emphasis on iron status.
Acta dermato-venereologica 2003;83(2):115-20.
2001: Lise Bathum; Lene Christiansen; Hanne Nybo; K A Ranberg; David Gaist; Bernard Jeune; Niels Erik Petersen; James W Vaupel; Kaare Christensen
Association of mutations in the hemochromatosis gene with shorter life expectancy.
Archives of internal medicine 2001;161(20):2441-4.
2001: Lene Christiansen; Anette Bygum; Marianne Käehne; A Jensen; Mogens Hørder; Niels Erik Petersen
Mutation screening of the entire coding region of the protoporphyrinogen oxidase gene using denaturing gradient gel electrophoresis and denaturing hplc.
Clinical chemistry 2001;47(6):1115-7.
2000: Lene Christiansen; Anette Bygum; A Jensen; Kristian Thomsen; Flemming Brandrup; Mogens Hørder; Niels Erik Petersen
Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
Human genetics 2000;107(6):612-4.
2000: Niels Erik Petersen; Marianne Käehne; Lene Christiansen; A Brock; Ole Hother-Nielsen; K Rasmussen
DGGE analysis of the coproporphyrinogen oxidase gene: two new mutations in DNA from Danish patients with hereditary coproporphyria.
Scandinavian journal of clinical and laboratory investigation 2000;60(7):617-25.
2000: Lene Christiansen; Anette Bygum; A Jensen; Flemming Brandrup; Kristian Thomsen; M Horder; Niels Erik Petersen
Uroporphyrinogen decarboxylase gene mutations in Danish patients with porphyria cutanea tarda.
Scandinavian journal of clinical and laboratory investigation 2000;60(7):611-5.
2000: Anette Bygum; Flemming Brandrup; Lene Christiansen; Niels Erik Petersen
[Porphyria cutanea tarda].
Ugeskrift for laeger 2000;162(14):2020-4.
1999: Lene Christiansen; Anette Bygum; Kristian Thomsen; Flemming Brandrup; Mogens Hørder; Niels Erik Petersen
Denaturing gradient gel electrophoresis analysis of the hemochromatosis (HFE) gene: impact of HFE gene mutations on the manifestation of porphyria cutanea tarda.
Clinical chemistry 1999;45(11):2025-6.
1999: Lene Christiansen; Cécile Ged; I Hombrados; J Brons-Poulsen; Antonio Fontanellas; Hubert de Verneuil; Mogens Hørder; Niels Erik Petersen
Screening for mutations in the uroporphyrinogen decarboxylase gene using denaturing gradient gel electrophoresis. Identification and characterization of six novel mutations associated with familial PCT.
Human mutation 1999;14(3):222-32.
1998: Lene Christiansen; Mogens Hørder
[It's about iron].
Ugeskrift for laeger 1998;160(3):289-90.