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David Christianson

Research Profile

Procedures

X Ray Crystallography

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Chemicals & Drugs

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Publications

TOP 3
Juan A Faraldos; Veronica Gonzalez; Mustafa Köksal; Amang Li; Fanglei Yu; David W Christianson; Rudolf K Allemann
Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.
Edward L D'Antonio; Yang Hai; David W Christianson
Structure and function of non-native metal clusters in human arginase I.
Edward L D'Antonio; David W Christianson
Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I.

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All Publications

2012: Juan A Faraldos; Veronica Gonzalez; Mustafa Köksal; Amang Li; Fanglei Yu; David W Christianson; Rudolf K Allemann
Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.
Journal of the American Chemical Society 2012;134(51):20844-8.
2012: Edward L D'Antonio; Yang Hai; David W Christianson
Structure and function of non-native metal clusters in human arginase I.
Biochemistry 2012;51(42):8399-409.
2012: Edward L D'Antonio; David W Christianson
Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 8):889-93.
2012: Mo Chen; David W Christianson; Barry M Twenter; Jeffrey D Winkler; Adegoke O Adeniji; Trevor M Penning
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorganic & medicinal chemistry letters 2012;22(10):3492-7.
2012: Mustafa Köksal; David E Cane; Wayne K W Chou; David W Christianson
Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate.
Biochemistry 2012;51(14):3011-20.
2012: Mustafa Köksal; David E Cane; Wayne K W Chou; David W Christianson
Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification.
Biochemistry 2012;51(14):3003-10.
2011: Patrick M Lombardi; Kathryn E Cole; Daniel P Dowling; David W Christianson
Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.
Current opinion in structural biology 2011;21(6):735-43.
2011: Edward L D'Antonio; David W Christianson
Crystal structures of complexes with cobalt-reconstituted human arginase I.
Biochemistry 2011;50(37):8018-27.
2011: Kathryn E Cole; Daniel P Dowling; Andrew J Phillips; Matthew A Boone; David W Christianson
Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.
Journal of the American Chemical Society 2011;133(32):12474-7.
2011: Mustafa Köksal; Reuben J Peters; Robert M Coates; Huayou Hu; David W Christianson
Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase.
Nature chemical biology 2011;7(7):431-3.
2011: Patrick M Lombardi; Heather D Angell; Douglas A Whittington; Erin F Flynn; Kanagalaghatta R Rajashankar; David W Christianson
Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases.
Biochemistry 2011;50(11):1808-17.
2011: Kathryn E Cole; Carol A Fierke; Samuel G Gattis; Heather D Angell; David W Christianson
Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .
Biochemistry 2011;50(2):258-65.
2011: Mustafa Köksal; Yinghua Jin; Robert M Coates; Rodney Croteau; David W Christianson
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Nature 2011;469(7328):116-20.
2010: Mustafa Köksal; Ina Zimmer; Jörg-Peter Schnitzler; David W Christianson
Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission.
Journal of molecular biology 2010;402(2):363-73.
2010: Daniel P Dowling; Monica Ilies; Kellen L Olszewski; Silvia Portugal; Maria M Mota; Manuel Llinás; David W Christianson
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection .
Biochemistry 2010;49(26):5600-8.
2010: Amos B Smith; Hui Xiong; Adam K Charnley; Meinrad Brenner; Eugen F Mesaros; Craig S Kenesky; Luigi Di Costanzo; David W Christianson; Ralph Hirschmann
Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones.
Organic letters 2010;12(13):2994-7.
2010: Daniel P Dowling; Samuel G Gattis; Carol A Fierke; David W Christianson
Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .
Biochemistry 2010;49(24):5048-56.
2010: Monica Ilies; Luigi Di Costanzo; Michelle L North; Jeremy A Scott; David W Christianson
2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
Journal of medicinal chemistry 2010;53(10):4266-76.
2010: Luigi Di Costanzo; Monica Ilies; Katherine J Thorn; David W Christianson
Inhibition of human arginase I by substrate and product analogues.
Archives of biochemistry and biophysics 2010;496(2):101-8.
2010: Julie A Aaron; Xin Lin; David E Cane; David W Christianson
Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates.
Biochemistry 2010;49(8):1787-97.
2009: Jae Hyung Kim; Lukasz J Bugaj; Young Jun Oh; Trinity J Bivalacqua; Sungwoo Ryoo; Kevin G Soucy; Lakshmi Santhanam; Alanah Webb; Andre Camara; Gautam Sikka; Daniel Nyhan; Artin A Shoukas; Monica Ilies; David W Christianson; Hunter C Champion; Dan E Berkowitz
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;107(4):1249-57.
2009: Heather A Gennadios; Veronica Gonzalez; Luigi Di Costanzo; Amang Li; Fanglei Yu; David J Miller; Rudolf K Allemann; David W Christianson
Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis.
Biochemistry 2009;48(26):6175-83.
2009: Luigi Di Costanzo; Jason Drury; David W Christianson; Trevor M Penning
Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1).
Molecular and cellular endocrinology 2009;301(1-2):191-8.
2009: Luigi Di Costanzo; Trevor M Penning; David W Christianson
Aldo-keto reductases in which the conserved catalytic histidine is substituted.
Chemico-biological interactions 2009;178(1-3):127-33.
2009: Jennifer M Chambers; David W Christianson; Zhaohui Han; P Aru Hill; Nicholas N Kuzma; Julie A Aaron; Ivan J Dmochowski
Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase.
Journal of the American Chemical Society 2009;131(2):563-9.
2009: Ekaterina Y Shishova; David E Ash; Luigi Di Costanzo; Frances A Emig; David W Christianson
Probing the specificity determinants of amino acid recognition by arginase.
Biochemistry 2009;48(1):121-31.
2008: Christopher A Butts; Joe Swift; Seung-Gu Kang; Luigi Di Costanzo; David W Christianson; Jeffery G Saven; Ivan J Dmochowski
Directing noble metal ion chemistry within a designed ferritin protein.
Biochemistry 2008;47(48):12729-39.
2008: Tatiana Y Zakharian; Luigi Di Costanzo; David W Christianson
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.
Organic & biomolecular chemistry 2008;6(18):3240-3.
2008: D P Dowling; Heather A Gennadios; Luigi Di Costanzo; David W Christianson
Evolution of the arginase fold and functional diversity.
Cellular and molecular life sciences : CMLS 2008;65(13):2039-55.
2008: Luigi Di Costanzo; Jason Drury; Trevor M Penning; David W Christianson
Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis.
The Journal of biological chemistry 2008;283(24):16830-9.
2008: Julie A Aaron; Jennifer M Chambers; Luigi Di Costanzo; Ivan J Dmochowski; Kevin M Jude; David W Christianson
Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
Journal of the American Chemical Society 2008;130(22):6942-3.
2008: Ekaterina Y Shishova; Fanglei Yu; David J Miller; Juan A Faraldos; Yuxin Zhao; Robert M Coates; Rudolf K Allemann; David E Cane; David W Christianson
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis.
The Journal of biological chemistry 2008;283(22):15431-9.
2008: Sungwoo Ryoo; Gaurav Gupta; Alexandre Benjo; Hyun Kyo Lim; Andre Camara; Gautam Sikka; Hyun Kyo Lim; Jayson Sohi; Lakshmi Santhanam; Kevin G Soucy; Eric Tuday; Ezra Baraban; Monica Ilies; Gary Gerstenblith; Daniel Nyhan; Artin A Shoukas; David W Christianson; Nicholas J Alp; Hunter C Champion; David L Huso; Dan E Berkowitz
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
Circulation research 2008;102(8):923-32.
2008: David W Christianson
Unearthing the roots of the terpenome.
Current opinion in chemical biology 2008;12(2):141-50.
2008: L Sangeetha Vedula; Jiaoyang Jiang; Tatiana Zakharian; David E Cane; David W Christianson
Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.
Archives of biochemistry and biophysics 2008;469(2):184-94.
2007: L Sangeetha Vedula; Yuxin Zhao; Robert M Coates; Tanetoshi Koyama; David E Cane; David W Christianson
Exploring biosynthetic diversity with trichodiene synthase.
Archives of biochemistry and biophysics 2007;466(2):260-6.
2007: Lakshmi Santhanam; Hyun Kyo Lim; Hyun Kyoung Lim; Victor Miriel; Tashalee Brown; Meet Patel; Sarit Balanson; Sungwoo Ryoo; Mirinda Anderson; Kaikobad Irani; Firdous A Khanday; Luigi Di Costanzo; Daniel Nyhan; Joshua M Hare; David W Christianson; RICHARD RIVERS; Artin A Shoukas; Dan E Berkowitz
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.
Circulation research 2007;101(7):692-702.
2007: Luigi Di Costanzo; Michael Haertlein; Flora Meilleur; Martine Moulin; David W Christianson
Expression, purification, assay, and crystal structure of perdeuterated human arginase I.
Archives of biochemistry and biophysics 2007;465(1):82-9.
2007: Luigi Di Costanzo; Michael E Pique; David W Christianson
Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
Journal of the American Chemical Society 2007;129(20):6388-9.
2007: DK Srivastava; Abir L Banerjee; Manas K Haldar; Kevin M Jude; Joel Kooren; Sanku Mallik; Sumathra Manokaran; David W Christianson
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II.
Journal of the American Chemical Society 2007;129(17):5528-37.
2007: David W Christianson
Chemistry. Roots of biosynthetic diversity.
Science (New York, N.Y.) 2007;316(5821):60-1.
2007: Hyunshun Shin; Heather A Gennadios; Douglas A Whittington; David W Christianson
Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.
Bioorganic & medicinal chemistry 2007;15(7):2617-23.
2007: Ekaterina Y Shishova; Luigi Di Costanzo; David E Cane; David W Christianson
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.
Biochemistry 2007;46(7):1941-51.
2007: Luigi Di Costanzo; german gomez; David W Christianson
Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity.
Journal of molecular biology 2007;366(2):481-93.
2007: Marco De Vivo; Bernd Ensing; Matteo Dal Peraro; german gomez; David W Christianson; Michael L Klein
Proton shuttles and phosphatase activity in soluble epoxide hydrolase.
Journal of the American Chemical Society 2007;129(2):387-94.
2006: Heather A Gennadios; David W Christianson
Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding.
Biochemistry 2006;45(51):15216-23.
2006: Luigi Di Costanzo; Lloyd V Flores; David W Christianson
Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function.
Proteins 2006;65(3):637-42.
2006: David W Christianson
Structural biology and chemistry of the terpenoid cyclases.
Chemical reviews 2006;106(8):3412-42.
2006: Heather A Gennadios; Xuechen Li; Douglas A Whittington; Carol A Fierke; David W Christianson
Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
Biochemistry 2006;45(26):7940-8.
2006: David W Christianson
Biochemistry. Five golden rings.
Science (New York, N.Y.) 2006;311(5766):1382-3.
2006: Kevin M Jude; Sanku Mallik; Sumathra Manokaran; Bidhan Roy; DK Srivastava; Abir L Banerjee; Manas K Haldar; David W Christianson
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity.
Journal of the American Chemical Society 2006;128(9):3011-8.
2006: german gomez; Christophe Morisseau; Bruce D Hammock; David W Christianson
Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids.
Protein science : a publication of the Protein Society 2006;15(1):58-64.
2005: Diana M Colleluori; Robert S Reczkowski; Frances A Emig; Evis Cama Hursever; J David Cox; Laura R Scolnick; Kevin Compher; Kevin M Jude; Shoufa Han; Ronald E Viola; David W Christianson; David E Ash
Probing the role of the hyper-reactive histidine residue of arginase.
Archives of biochemistry and biophysics 2005;444(1):15-26.
2005: L Sangeetha Vedula; David E Cane; David W Christianson
Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase.
Biochemistry 2005;44(38):12719-27.
2005: Luigi Di Costanzo; Alfonso Mora; Augusto C Ochoa; Paulo C Rodriguez; Guadalupe Sabio; Francisco Centeno; David W Christianson
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13058-63.
2005: Marcy Hernick; Heather A Gennadios; Douglas A Whittington; Kristin M Rusche; David W Christianson; Carol A Fierke
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
The Journal of biological chemistry 2005;280(17):16969-78.
2005: L Sangeetha Vedula; Michael J Rynkiewicz; Hyung-Jung Pyun; Robert M Coates; David E Cane; David W Christianson
Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.
Biochemistry 2005;44(16):6153-63.
2005: David W Christianson
Arginase: structure, mechanism, and physiological role in male and female sexual arousal.
Accounts of chemical research 2005;38(3):191-201.
2004: Noel Kim; David W Christianson; Abdulmaged M Traish
Role of arginase in the male and female sexual arousal response.
The Journal of nutrition 2004;134(10 Suppl):2873S-2879S; discussion 2895S.
2004: Hyunshun Shin; Evis Cama Hursever; David W Christianson
Design of amino acid aldehydes as transition-state analogue inhibitors of arginase.
Journal of the American Chemical Society 2004;126(33):10278-84.
2004: Evis Cama Hursever; Stéphanie Pethe; Jean-Luc Boucher; Shoufa Han; Frances A Emig; David E Ash; Ronald E Viola; Daniel Mansuy; David W Christianson
Inhibitor coordination interactions in the binuclear manganese cluster of arginase.
Biochemistry 2004;43(28):8987-99.
2004: german gomez; Christophe Morisseau; Bruce D Hammock; David W Christianson
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.
Biochemistry 2004;43(16):4716-23.
2004: Douglas A Whittington; Jeffrey H Grubb; Abdul Waheed; Gul N Shah; William S Sly; David W Christianson
Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
The Journal of biological chemistry 2004;279(8):7223-8.
2003: Evis Cama Hursever; Hyunshun Shin; David W Christianson
Design of amino acid sulfonamides as transition-state analogue inhibitors of arginase.
Journal of the American Chemical Society 2003;125(43):13052-7.
2003: Lingyun Xu; Brendan Hilliard; Ruaidhrí J Carmody; Galit Tsabary; Hyunshun Shin; David W Christianson; Youhai H Chen
Arginase and autoimmune inflammation in the central nervous system.
Immunology 2003;110(1):141-8.
2003: Evis Cama Hursever; Diana M Colleluori; Frances A Emig; Hyunshun Shin; Soo Woong Kim; Noel Kim; Abdulmaged M Traish; David E Ash; David W Christianson
Human arginase II: crystal structure and physiological role in male and female sexual arousal.
Biochemistry 2003;42(28):8445-51.
2003: Douglas A Whittington; Kristin M Rusche; Hyunshun Shin; Carol A Fierke; David W Christianson
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8146-50.
2003: Evis Cama Hursever; Frances A Emig; David E Ash; David W Christianson
Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I.
Biochemistry 2003;42(25):7748-58.
2002: Douglas A Whittington; Mitchell L Wise; Marek Urbansky; Robert M Coates; Rodney B Croteau; David W Christianson
Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15375-80.
2002: Kevin M Jude; S Kirk Wright; Chingkuang Tu; David N Silverman; Ronald E Viola; David W Christianson
Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry 2002;41(8):2485-91.
2002: Chu-Young Kim; Douglas A Whittington; Jeanne S Chang; John Liao; Jesse A May; David W Christianson
Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
Journal of medicinal chemistry 2002;45(4):888-93.
2002: Michael J Rynkiewicz; David E Cane; David W Christianson
X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity.
Biochemistry 2002;41(6):1732-41.
2002: Ryan D Madder; Chu-Young Kim; Pooja P Chandra; Jeffrey B Doyon; Teaster A Baird; Carol A Fierke; David W Christianson; Judith G Voet; Ahamindra Jain
Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase.
The Journal of organic chemistry 2002;67(2):582-4.
2001: Michael J Rynkiewicz; David E Cane; David W Christianson
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13543-8.
2001: Chu-Young Kim; Pooja P Chandra; Ahamindra Jain; David W Christianson
Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
Journal of the American Chemical Society 2001;123(39):9620-7.
2001: Douglas A Whittington; Abdul Waheed; Barbara Ulmasov; Gul N Shah; Jeffrey H Grubb; William S Sly; David W Christianson
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9545-50.
2001: Lopeti T Lavulo; TM Sossong; Michael Brigham-Burke; Michael Doyle; J David Cox; David W Christianson; David E Ash
Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
The Journal of biological chemistry 2001;276(17):14242-8.
2001: J David Cox; Evis Cama Hursever; Diana M Colleluori; Stéphanie Pethe; Jean-Luc Boucher; Daniel Mansuy; David E Ash; David W Christianson
Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
Biochemistry 2001;40(9):2689-701.
2001: Noel Kim; J David Cox; RF Baggio; Frances A Emig; S K Mistry; Sandra L Harper; David W Speicher; Sidney Morris; David E Ash; Abdulmaged M Traish; David W Christianson
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
Biochemistry 2001;40(9):2678-88.
2000: J David Cox; J A Hunt; Kevin Compher; Carol A Fierke; David W Christianson
Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry 2000;39(45):13687-94.
2000: J M Caruthers; I Kang; Michael J Rynkiewicz; David E Cane; David W Christianson
Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.
The Journal of biological chemistry 2000;275(33):25533-9.
2000: T Yamada; Christophe Morisseau; J E Maxwell; MA Argiriadi; David W Christianson; Bruce D Hammock
Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase.
The Journal of biological chemistry 2000;275(30):23082-8.
2000: MA Argiriadi; Christophe Morisseau; Marvin H Goodrow; Deanna L Dowdy; Bruce D Hammock; David W Christianson
Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
The Journal of biological chemistry 2000;275(20):15265-70.
2000: Jeffrey B Doyon; E A Hansen; Chu-Young Kim; J S Chang; David W Christianson; R D Madder; Judith G Voet; T A Baird; Carol A Fierke; Ahamindra Jain
Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II.
Organic letters 2000;2(9):1189-92.
2000: J A Hunt; CA Lesburg; David W Christianson; Richard B Thompson; Carol A Fierke
Active-site engineering of carbonic anhydrase and its application to biosensors.
EXS 2000;(90):221-40.
2000: T Stams; David W Christianson
X-ray crystallographic studies of mammalian carbonic anhydrase isozymes.
EXS 2000;(90):159-74.
2000: David E Ash; J David Cox; David W Christianson
Arginase: a binuclear manganese metalloenzyme.
Metal ions in biological systems 2000;37():407-28.
1999: RF Baggio; J David Cox; Sandra L Harper; David W Speicher; David W Christianson
A new chromophoric assay for arginase activity.
Analytical biochemistry 1999;276(2):251-3.
1999: J David Cox; Noel Kim; Abdulmaged M Traish; David W Christianson
Arginase-boronic acid complex highlights a physiological role in erectile function.
Nature structural biology 1999;6(11):1043-7.
1999: MA Argiriadi; Christophe Morisseau; Bruce D Hammock; David W Christianson
Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10637-42.
1999: RF Baggio; Frances A Emig; David W Christianson; David E Ash; S Chakder; Satish Rattan
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1409-16.
1999: David W Christianson; J David Cox
Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes.
Annual review of biochemistry 1999;68():33-57.
1998: Somashekarappa Niranjanakumari; T Stams; Sharon M Crary; David W Christianson; Carol A Fierke
Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15212-7.
1998: CA Lesburg; J M Caruthers; C M Paschall; David W Christianson
Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism.
Current opinion in structural biology 1998;8(6):695-703.
1998: P A Boriack-Sjodin; S Zeitlin; Hwang-Hsing Chen; L Crenshaw; S Gross; Anura P Dantanarayana; Pete Delgado; Jesse A May; Tom R Dean; David W Christianson
Structural analysis of inhibitor binding to human carbonic anhydrase II.
Protein science : a publication of the Protein Society 1998;7(12):2483-9.
1998: David E Ash; Laura R Scolnick; Z F Kanyo; Jerry Vockley; Stephen D Cederbaum; David W Christianson
Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase.
Molecular genetics and metabolism 1998;64(4):243-9.
1998: T Stams; Somashekarappa Niranjanakumari; Carol A Fierke; David W Christianson
Ribonuclease P protein structure: evolutionary origins in the translational apparatus.
Science (New York, N.Y.) 1998;280(5364):752-5.
1998: C M Lukacs; Harvey Rubin; David W Christianson
Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry 1998;37(10):3297-304.
1998: T Stams; Y Chen; P A Boriack-Sjodin; JD Hurt; John Liao; Jesse A May; Tom R Dean; Philip J Laipis; David N Silverman; David W Christianson
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein science : a publication of the Protein Society 1998;7(3):556-63.
1997: CA Lesburg; C Huang; David W Christianson; Carol A Fierke
Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry 1997;36(50):15780-91.
1997: CA Lesburg; G Zhai; David E Cane; David W Christianson
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
Science (New York, N.Y.) 1997;277(5333):1820-4.
1997: Laura R Scolnick; Z F Kanyo; R C Cavalli; David E Ash; David W Christianson
Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
Biochemistry 1997;36(34):10558-65.
1997: David W Christianson
Structural chemistry and biology of manganese metalloenzymes.
Progress in biophysics and molecular biology 1997;67(2-3):217-52.
1996: L R Scolnick; David W Christianson
X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry 1996;35(51):16429-34.
1996: T Stams; Smita K Nair; T Okuyama; A Waheed; William S Sly; David W Christianson
Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13589-94.
1996: Z F Kanyo; L R Scolnick; David E Ash; David W Christianson
Structure of a unique binuclear manganese cluster in arginase.
Nature 1996;383(6600):554-7.
1996: C M Lukacs; J Q Zhong; M I Plotnick; Harvey Rubin; Barry S Cooperman; David W Christianson
Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement.
Nature structural biology 1996;3(10):888-93.
1996: R W Heck; P A Boriack-Sjodin; Minzhang Qian; Chingkuang Tu; David W Christianson; Philip J Laipis; David N Silverman
Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V.
Biochemistry 1996;35(36):11605-11.
1996: E S Stavridi; K O'Malley; C M Lukacs; WT Moore; John D Lambris; David W Christianson; Harvey Rubin; Barry S Cooperman
Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.
Biochemistry 1996;35(33):10608-15.
1996: C M Lukacs; David W Christianson
Is the binding of beta-amyloid protein to antichymotrypsin in Alzheimer plaques mediated by a beta-strand insertion?
Proteins 1996;25(4):420-4.
1996: C C Huang; CA Lesburg; L L Kiefer; Carol A Fierke; David W Christianson
Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry 1996;35(11):3439-46.
1996: Smita K Nair; D Elbaum; David W Christianson
Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor.
The Journal of biological chemistry 1996;271(2):1003-7.
1995: P A Boriack-Sjodin; R W Heck; Philip J Laipis; David N Silverman; David W Christianson
Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10949-53.
1995: CA Lesburg; M D Lloyd; David E Cane; David W Christianson
Crystallization and preliminary X-ray diffraction analysis of recombinant pentalenene synthase.
Protein science : a publication of the Protein Society 1995;4(11):2436-8.
1995: J A Ippolito; Smita K Nair; R S Alexander; L L Kiefer; Carol A Fierke; David W Christianson
Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site.
Protein engineering 1995;8(10):975-80.
1995: P A Boriack; David W Christianson; J Kingery-Wood; G M Whitesides
Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
Journal of medicinal chemistry 1995;38(13):2286-91.
1995: J A Ippolito; T T Baird; S A McGee; David W Christianson; Carol A Fierke
Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5017-21.
1995: Smita K Nair; J F Krebs; David W Christianson; Carol A Fierke
Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry 1995;34(12):3981-9.
1994: J A Ippolito; David W Christianson
Structural consequences of redesigning a protein-zinc binding site.
Biochemistry 1994;33(51):15241-9.
1994: D S Katz; S P White; W Huang; R Kumar; David W Christianson
Structure determination of aquomet porcine hemoglobin at 2.8 A resolution.
Journal of molecular biology 1994;244(5):541-53.
1994: A Jain; George M Whitesides; R S Alexander; David W Christianson
Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.
Journal of medicinal chemistry 1994;37(13):2100-5.
1994: A Wei; Harvey Rubin; Barry S Cooperman; David W Christianson
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop.
Nature structural biology 1994;1(4):251-8.
1994: G M Smith; R S Alexander; David W Christianson; Brian McKeever; G S Ponticello; J P Springer; W C Randall; JJ Baldwin; C N Habecker
Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
Protein science : a publication of the Protein Society 1994;3(1):118-25.
1993: J F Krebs; J A Ippolito; David W Christianson; Carol A Fierke
Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
The Journal of biological chemistry 1993;268(36):27458-66.
1993: D S Katz; A Wei; Q Zhong; Harvey Rubin; Barry S Cooperman; David W Christianson
Crystallization and atomic resolution X-ray diffraction analysis of antichymotrypsin variants.
Biochemical and biophysical research communications 1993;196(2):752-7.
1993: N B Tweedy; Smita K Nair; S A Paterno; Carol A Fierke; David W Christianson
Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.
Biochemistry 1993;32(41):10944-9.
1993: J A Ippolito; David W Christianson
Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.
Biochemistry 1993;32(38):9901-5.
1993: D S Katz; David W Christianson
Modeling the uncleaved serpin antichymotrypsin and its chymotrypsin complex.
Protein engineering 1993;6(7):701-9.
1993: M H Lee; H S Pankratz; S Wang; Robert A Scott; M G Finnegan; Michael K Johnson; J A Ippolito; David W Christianson; Robert P Hausinger
Purification and characterization of Klebsiella aerogenes UreE protein: a nickel-binding protein that functions in urease metallocenter assembly.
Protein science : a publication of the Protein Society 1993;2(6):1042-52.
1993: Smita K Nair; David W Christianson
Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.
Biochemistry 1993;32(17):4506-14.
1993: Smita K Nair; David W Christianson
Crystallographic studies of azide binding to human carbonic anhydrase II.
European journal of biochemistry / FEBS 1993;213(1):507-15.
1993: R S Alexander; L L Kiefer; Carol A Fierke; David W Christianson
Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.
Biochemistry 1993;32(6):1510-8.
1992: A M Cappalonga; R S Alexander; David W Christianson
Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes.
The Journal of biological chemistry 1992;267(27):19192-7.
1992: J A Ippolito; David W Christianson
The contribution of halogen atoms to protein-ligand interactions.
International journal of biological macromolecules 1992;14(4):193-7.
1992: A Wei; Harvey Rubin; Barry S Cooperman; N Schechter; David W Christianson
Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin.
Journal of molecular biology 1992;226(1):273-6.
1992: Z F Kanyo; C Y Chen; F Daghigh; David E Ash; David W Christianson
Crystallization and oligomeric structure of rat liver arginase.
Journal of molecular biology 1992;224(4):1175-7.
1991: Smita K Nair; David W Christianson
Structural properties of human carbonic anhydrase II at pH 9.5.
Biochemical and biophysical research communications 1991;181(2):579-84.
1991: R S Alexander; Smita K Nair; David W Christianson
Engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry 1991;30(46):11064-72.
1991: J F Krebs; Carol A Fierke; R S Alexander; David W Christianson
Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II.
Biochemistry 1991;30(38):9153-60.
1991: Smita K Nair; T L Calderone; David W Christianson; Carol A Fierke
Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
The Journal of biological chemistry 1991;266(26):17320-5.
1991: Z F Kanyo; David W Christianson
Biological recognition of phosphate and sulfate.
The Journal of biological chemistry 1991;266(7):4264-8.
1991: David W Christianson
Structural biology of zinc.
Advances in protein chemistry 1991;42():281-355.
1990: J A Ippolito; R S Alexander; David W Christianson
Hydrogen bond stereochemistry in protein structure and function.
Journal of molecular biology 1990;215(3):457-71.
1990: David W Christianson; R S Alexander
Another catalytic triad?
Nature 1990;346(6281):225.
1989: David W Christianson; S Mangani; Gil Shoham; William N Lipscomb
Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A.
The Journal of biological chemistry 1989;264(22):12849-53.
1988: Gil Shoham; David W Christianson; D A Oren
Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):684-8.