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Graham Christie

Research Profile

Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Disorders

Alzheimer's Disease

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

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Publications

TOP 3
James W A Ritchie; Yun-Bo Shi; Y Hayashi; Fiona E Baird; Ruth Muchekehu; Graham R Christie; Peter M Taylor
A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors.
Edward T Parkin; Alison Trew; Graham R Christie; Andrew Faller; Ruth Mayer; Anthony J Turner; Nigel M Hooper
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.
Graham R Christie; Eric Hajduch; Harinder S Hundal; Christopher G Proud; Peter M Taylor
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner.

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All Publications

2003: James W A Ritchie; Yun-Bo Shi; Y Hayashi; Fiona E Baird; Ruth Muchekehu; Graham R Christie; Peter M Taylor
A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):653-61.
2002: Edward T Parkin; Alison Trew; Graham R Christie; Andrew Faller; Ruth Mayer; Anthony J Turner; Nigel M Hooper
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.
Biochemistry 2002;41(15):4972-81.
2002: Graham R Christie; Eric Hajduch; Harinder S Hundal; Christopher G Proud; Peter M Taylor
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner.
The Journal of biological chemistry 2002;277(12):9952-7.
2001: Graham R Christie; Russell Hyde; Harinder S Hundal
Regulation of amino acid transporters by amino acid availability.
Current opinion in clinical nutrition and metabolic care 2001;4(5):425-31.
2001: David Riddell; Graham R Christie; Ishrut Hussain; Colin Dingwall
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.
Current biology : CB 2001;11(16):1288-93.
2001: Sophia N Karagiannis; J K Warrack; K H Jennings; PR Murdock; Graham R Christie; K Moulder; Brian J Sutton; Hannah J Gould
Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells.
Immunology 2001;103(3):319-31.
2001: Ishrut Hussain; Graham R Christie; Klaus Schneider; S Moore; Colin Dingwall
Prodomain processing of Asp1 (BACE2) is autocatalytic.
The Journal of biological chemistry 2001;276(26):23322-8.
2001: Russell Hyde; Graham R Christie; Gary J Litherland; Eric Hajduch; Peter M Taylor; Harinder S Hundal
Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes.
The Biochemical journal 2001;355(Pt 3):563-8.
2001: James W A Ritchie; Fiona E Baird; Graham R Christie; A Stewart; SY Low; Harinder S Hundal; Peter M Taylor
Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2001;11(5):259-70.
2000: Ishrut Hussain; David J Powell; David R Howlett; GA Chapman; L Gilmour; PR Murdock; David Tew; Thomas D Meek; C Chapman; Klaus Schneider; S J Ratcliffe; D Tattersall; TT Testa; Christopher Southan; D M Ryan; DL Simmons; Frank S Walsh; Colin Dingwall; Graham R Christie
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
Molecular and cellular neurosciences 2000;16(5):609-19.
2000: David R Howlett; DL Simmons; Colin Dingwall; Graham R Christie
In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase.
Trends in neurosciences 2000;23(11):565-70.
2000: GJ Peter; T B Panova; Graham R Christie; Peter M Taylor
Cysteine residues in the C-terminus of the neutral- and basic-amino-acid transporter heavy-chain subunit contribute to functional properties of the system b(0,+)-type amino acid transporter.
The Biochemical journal 2000;351 Pt 3():677-82.
2000: S R Tipnis; Nigel M Hooper; Ralph J Hyde; EH Karran; Graham R Christie; Anthony J Turner
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
The Journal of biological chemistry 2000;275(43):33238-43.
2000: RV Ward; K H Jennings; R Jepras; W Neville; Davina E Owen; J Hawkins; Graham R Christie; John B Davis; A George; EH Karran; David R Howlett
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide.
The Biochemical journal 2000;348 Pt 1():137-44.
2000: R C Gardner; Stephen J Assinder; Graham R Christie; Grant G F Mason; RE Markwell; H Wadsworth; M McLaughlin; R King; MC Chabot-Fletcher; JJ Breton; D Allsop; A Jennifer Rivett
Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells.
The Biochemical journal 2000;346 Pt 2():447-54.
2000: Rab Prinjha; S E Moore; Mary Vinson; S Blake; R Morrow; Graham R Christie; David Michalovich; DL Simmons; Frank S Walsh
Inhibitor of neurite outgrowth in humans.
Nature 2000;403(6768):383-4.
1999: Ishrut Hussain; D Powell; David R Howlett; David Tew; Thomas D Meek; C Chapman; IS Gloger; K E Murphy; Christopher Southan; D M Ryan; TS Smith; DL Simmons; Frank S Walsh; Colin Dingwall; Graham R Christie
Identification of a novel aspartic protease (Asp 2) as beta-secretase.
Molecular and cellular neurosciences 1999;14(6):419-27.
1999: Graham R Christie; RE Markwell; Carol W Gray; L Smith; F Godfrey; F Mansfield; H Wadsworth; R King; M McLaughlin; D G Cooper; RV Ward; David R Howlett; Tobias Hartmann; S F Lichtenthaler; Konrad Beyreuther; J Underwood; S K Gribble; Roberto Cappai; Colin L Masters; A Tamaoka; R L Gardner; A Jennifer Rivett; EH Karran; D Allsop
Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.
Journal of neurochemistry 1999;73(1):195-204.
1998: EH Karran; D Allsop; Graham R Christie; J Davis; C Gray; F Mansfield; RV Ward
Presenilins--in search of functionality.
Biochemical Society transactions 1998;26(3):491-6.
1998: D Allsop; David R Howlett; Graham R Christie; EH Karran
Fibrillogenesis of beta-amyloid.
Biochemical Society transactions 1998;26(3):459-63.
1998: A E Marolewski; DR Buckle; Graham R Christie; D L Earnshaw; PL Flamberg; Lisa A Marshall; DG Smith; RJ Mayer
CD23 (FcepsilonRII) release from cell membranes is mediated by a membrane-bound metalloprotease.
The Biochemical journal 1998;333 ( Pt 3)():573-9.
1997: Graham R Christie; A Barton; Brian J Bolognese; DR Buckle; RM Cook; Michael Hansbury; G P Harper; Lisa A Marshall; ME McCord; K Moulder; PR Murdock; S M Seal; V M Spackman; B J Weston; RJ Mayer
IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (Fc epsilonRII).
European journal of immunology 1997;27(12):3228-35.
1997: HE McDowell; T Walker; Eric Hajduch; Graham R Christie; Ian H Batty; C Peter Downes; Harinder S Hundal
Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells.
European journal of biochemistry / FEBS 1997;247(1):306-13.
1995: Graham R Christie; I Dacey; B J Weston
Identification of a soluble, high affinity human interleukin 4 binding protein in normal human urine.
Cytokine 1995;7(4):305-10.