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John Christodoulou

Research Profile

Procedures

Nuclear Magnetic Resonance, Biomolecular

Physiology

Protein Folding

Chemicals & Drugs

Concepts & Ideas

Anatomy

Ribosomes

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Disorders

Co-author Network

Publications

TOP 3
Mun Peak Nyon; John Kirkpatrick; Lisa D Cabrita; John Christodoulou; Bibek Gooptu
1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin.
Christopher Waudby; Lisa D Cabrita; Christopher M Dobson; Lynn F Gladden; Mick D Mantle; John Christodoulou
Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.
Edward P O'Brien; Michele Vendruscolo; John Christodoulou; Christopher M Dobson
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.

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All Publications

2012: Mun Peak Nyon; John Kirkpatrick; Lisa D Cabrita; John Christodoulou; Bibek Gooptu
1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin.
Biomolecular NMR assignments 2012;6(2):153-6.
2012: Christopher Waudby; Lisa D Cabrita; Christopher M Dobson; Lynn F Gladden; Mick D Mantle; John Christodoulou
Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.
Journal of the American Chemical Society 2012;134(28):11312-5.
2012: Edward P O'Brien; Michele Vendruscolo; John Christodoulou; Christopher M Dobson
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.
Journal of the American Chemical Society 2012;134(26):10920-32.
2012: Christopher Waudby; John Christodoulou
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2012;219():46-52.
2012: Mun Peak Nyon; Anathe O M Patschull; Benoit D Roussel; Lakshmi Segu; Konstantinos Thalassinos; Christopher Waudby; Tracey E Barrett; Lisa D Cabrita; John Christodoulou; Ugo I Ekeowa; Marian Hill; Noor Kalsheker; Richard Kerr; John Kirkpatrick; Géraldine R Lévy; David A Lomas; Bibek Gooptu
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
Structure (London, England : 1993) 2012;20(3):504-12.
2011: Andrew Baldwin; Paul D Barker; John Christodoulou; Glyn L Devlin; Spencer J Anthony-Cahill; Anthony Fitzpatrick; Sally L Gras; Tuomas P J Knowles; Sarah Meehan; Maria F Mossuto; Sarah Lucy Shammas; Gian Gaetano Tartaglia; Michele Vendruscolo; Christopher Waudby; Christopher M Dobson
Metastability of native proteins and the phenomenon of amyloid formation.
Journal of the American Chemical Society 2011;133(36):14160-3.
2011: Edward P O'Brien; Michele Vendruscolo; John Christodoulou; Christopher M Dobson
New scenarios of protein folding can occur on the ribosome.
Journal of the American Chemical Society 2011;133(3):513-26.
2010: Erwin J De Genst; Tim Guilliams; Joke Wellens; Elizabeth M O'Day; Christopher Waudby; Sarah Meehan; Mireille Dumoulin; Shang-Te Danny Hsu; Nunilo Cremades; Koen H G Verschueren; Els Pardon; Lode Wyns; Jan Steyaert; John Christodoulou; Christopher M Dobson
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
Journal of molecular biology 2010;402(2):326-43.
2010: Christine L Hagan; Russell J K Johnson; Anne Dhulesia; Mireille Dumoulin; Janice Dumont; Erwin De Genst; John Christodoulou; Carol V Robinson; Christopher M Dobson; Janet R Kumita
A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Protein engineering, design & selection : PEDS 2010;23(7):499-506.
2010: Christopher Waudby; Tuomas P J Knowles; Glyn L Devlin; Jeremy N Skepper; Heath Ecroyd; John A Carver; Mark E Welland; John Christodoulou; Christopher M Dobson; Sarah Meehan
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
Biophysical journal 2010;98(5):843-51.
2010: Lisa D Cabrita; Christopher M Dobson; John Christodoulou
Protein folding on the ribosome.
Current opinion in structural biology 2010;20(1):33-45.
2009: Lisa D Cabrita; Shang-Te Danny Hsu; Helene Launay; Christopher M Dobson; John Christodoulou
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22239-44.
2009: Cintia Roodveldt; CARLOS WALTER BERTONCINI; August Andersson; Annemieke T van der Goot; Shang-Te Danny Hsu; Rafael Fernández-Montesinos; Jannie de Jong; Tjakko J van Ham; Ellen A A Nollen; David Pozo Perez; John Christodoulou; Christopher M Dobson
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.
The EMBO journal 2009;28(23):3758-70.
2009: Anneleen Vuchelen; Elizabeth O'Day; Erwin De Genst; Els Pardon; Lode Wyns; Mireille Dumoulin; Christopher M Dobson; John Christodoulou; Shang-Te Danny Hsu
(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Biomolecular NMR assignments 2009;3(2):231-3.
2009: Christofer Lendel; CARLOS WALTER BERTONCINI; Nunilo Cremades; Christopher Waudby; Michele Vendruscolo; Christopher M Dobson; Dale Schenk; John Christodoulou; Gergely Toth
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.
Biochemistry 2009;48(35):8322-34.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; Paola Fucini; John Christodoulou; Christopher M Dobson
Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy.
Journal of the American Chemical Society 2009;131(24):8366-7.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; John Christodoulou; Christopher M Dobson
1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states.
Biomolecular NMR assignments 2009;3(1):29-31.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; Paola Fucini; Christopher M Dobson; John Christodoulou
Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum.
Journal of molecular biology 2009;388(4):865-79.
2008: Jie-Rong Huang; Shang-Te Danny Hsu; John Christodoulou; Sophie E Jackson
The extremely slow-exchanging core and acid-denatured state of green fluorescent protein.
HFSP journal 2008;2(6):378-87.
2008: Pak-Ho Chan; Els Pardon; Linda Menzer; Erwin De Genst; Janet R Kumita; John Christodoulou; Dirk Saerens; Alain Brans; Fabrice Bouillenne; David B Archer; Carol V Robinson; Serge Muyldermans; Alain Matagne; Christina Redfield; Lode Wyns; Christopher M Dobson; Mireille Dumoulin
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Biochemistry 2008;47(42):11041-54.
2008: Cintia Roodveldt; John Christodoulou; Christopher M Dobson
Immunological features of alpha-synuclein in Parkinson's disease.
Journal of cellular and molecular medicine 2008;12(5B):1820-9.
2008: Jörg Gsponer; John Christodoulou; Andrea Cavalli; Jennifer M Bui; Barbara Richter; Christopher M Dobson; Michele Vendruscolo
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Structure (London, England : 1993) 2008;16(5):736-46.
2008: Robert C Rivers; Janet R Kumita; Gian Gaetano Tartaglia; Matthew M. Dedmon; Amol P Pawar; Michele Vendruscolo; Christopher M Dobson; John Christodoulou
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.
Protein science : a publication of the Protein Society 2008;17(5):887-98.
2008: Andrew Baldwin; Spencer J Anthony-Cahill; Tuomas P J Knowles; Guy Lippens; John Christodoulou; Paul D Barker; Christopher M Dobson
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
Angewandte Chemie (International ed. in English) 2008;47(18):3385-7.
2007: Shang-Te Danny Hsu; Paola Fucini; Lisa D Cabrita; Hélène Launay; Christopher M Dobson; John Christodoulou
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16516-21.
2007: Andrew Baldwin; John Christodoulou; Paul D Barker; Christopher M Dobson; Guy Lippens
Contribution of rotational diffusion to pulsed field gradient diffusion measurements.
The Journal of chemical physics 2007;127(11):114505.
2007: Jie-rong Huang; Timothy D Craggs; John Christodoulou; Sophie E Jackson
Stable intermediate states and high energy barriers in the unfolding of GFP.
Journal of molecular biology 2007;370(2):356-71.
2006: Vidya Chandran; Elliott J Stollar; Kresten Lindorff-Larsen; Jeffrey F Harper; Walter J Chazin; Christopher M Dobson; Ben F Luisi; John Christodoulou
Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
Journal of molecular biology 2006;357(2):400-10.
2006: Andrew Baldwin; Reto Bader; John Christodoulou; Cait E MacPhee; Christopher M Dobson; Paul D Barker
Cytochrome display on amyloid fibrils.
Journal of the American Chemical Society 2006;128(7):2162-3.
2005: Catherine A Keetch; E H C Bromley; Margaret McCammon; Nan Wang; John Christodoulou; Carol V Robinson
L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.
The Journal of biological chemistry 2005;280(50):41667-74.
2005: Russell J K Johnson; John Christodoulou; Mireille Dumoulin; Gemma L Caddy; Marcos J C Alcocer; Gareth J Murtagh; Janet R Kumita; Göran Larsson; Carol V Robinson; David B Archer; Ben F Luisi; Christopher M Dobson
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.
Journal of molecular biology 2005;352(4):823-36.
2005: Matthew M. Dedmon; John Christodoulou; Mark R Wilson; Christopher M Dobson
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
The Journal of biological chemistry 2005;280(15):14733-40.
2005: Matthew M. Dedmon; Kresten Lindorff-Larsen; John Christodoulou; Michele Vendruscolo; Christopher M Dobson
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations.
Journal of the American Chemical Society 2005;127(2):476-7.
2004: John Christodoulou; Göran Larsson; Paola Fucini; Sean connell; Thelma A Pertinhez; Charlotte L Hanson; Christina Redfield; Knud H Nierhaus; Carol V Robinson; Jürgen Schleucher; Christopher M Dobson
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):10949-54.
2004: Caroline F Wright; John Christodoulou; Christopher M Dobson; Jane Clarke
The importance of loop length in the folding of an immunoglobulin domain.
Protein engineering, design & selection : PEDS 2004;17(5):443-53.