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Charleen Chu

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TOP 3
Jared E Knickelbein; Jessica Kovarik; Deepinder K Dhaliwal; Charleen T Chu
Acanthamoeba keratitis: A clinicopathologic case report and review of the literature.
Elizabeth A Oczypok; Tim D Oury; Charleen T Chu
It's a cell-eat-cell world: autophagy and phagocytosis.
Salvatore J Cherra; Aaron M Gusdon; Kirill Kiselyov; Erin Steer; Charleen T Chu
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.

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All Publications

2013: Jared E Knickelbein; Jessica Kovarik; Deepinder K Dhaliwal; Charleen T Chu
Acanthamoeba keratitis: A clinicopathologic case report and review of the literature.
Human pathology 2013;44(5):918-22.
2013: Elizabeth A Oczypok; Tim D Oury; Charleen T Chu
It's a cell-eat-cell world: autophagy and phagocytosis.
The American journal of pathology 2013;182(3):612-22.
2013: Salvatore J Cherra; Aaron M Gusdon; Kirill Kiselyov; Erin Steer; Charleen T Chu
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
The American journal of pathology 2013;182(2):474-84.
2012: Vivek P Patel; Donald B DeFranco; Charleen T Chu
Altered transcription factor trafficking in oxidatively-stressed neuronal cells.
Biochimica et biophysica acta 2012;1822(11):1773-82.
2012: Aaron M Gusdon; Bennett Van Houten; Jianhui Zhu; Charleen T Chu
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy.
Neurobiology of disease 2012;45(3):962-72.
2012: Jian-Hui Zhu; H Cimen; A M Gusdon; E Koc; B Van Houten; Charleen T Chu
Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2.
Cell death & disease 2012;3():e312.
2011: Ruben K Dagda; S Green; A M Gusdon; C Li; I Pien; Stefan Strack; B Van Houten; S J Cherra; Charleen T Chu
Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease.
Cell death and differentiation 2011;18(12):1914-23.
2011: Daniel J Klionsky; Guido Kroemer; Beth Levine; Thomas J Melia; Noboru Mizushima; David C Rubinsztein; Anne Simonsen; Andrew Thorburn; Michael Thumm; Eric H Baehrecke; John H Brumell; Charleen T Chu; Patrice Codogno; Ana Maria Cuervo; Jayanta Debnath; Vojo Deretic; Zvulun Elazar; Eeva-Liisa Eskelinen; Steven Finkbeiner; Juan Fueyo-Margareto; David Gewirtz; Marja Jäättelä; Sharon A Tooze
A comprehensive glossary of autophagy-related molecules and processes (2nd edition).
Autophagy 2011;7(11):1273-94.
2011: Charleen T Chu
Autophagy in different flavors: dysregulated protein degradation in neurological diseases.
Neurobiology of disease 2011;43(1):1-3.
2011: Edward D Plowey; Charleen T Chu
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?
Neurobiology of disease 2011;43(1):60-7.
2011: Aaron M Gusdon; Charleen T Chu
To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease.
Antioxidants & redox signaling 2011;14(10):1979-87.
2011: Vivek P Patel; Charleen T Chu
Nuclear transport, oxidative stress, and neurodegeneration.
International journal of clinical and experimental pathology 2011;4(3):215-29.
2011: Victor S Van Laar; Beth Arnold; Steven J Cassady; Charleen T Chu; Edward A Burton; SB Berman
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.
Human molecular genetics 2011;20(5):927-40.
2011: Xiaoming Hu; Zhongfang Weng; Charleen T Chu; Lili Zhang; Guodong Cao; Yanqin Gao; Armando Signore; Jianhui Zhu; Teresa G Hastings; J Timothy Greenamyre; Jun Chen
Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(1):247-61.
2011: David K Simon; Charleen T Chu; Russell H Swerdlow
Mitochondria and Parkinson's disease.
Parkinson's disease 2011;2011():261791.
2011: Jianhui Zhu; Ruben K Dagda; Charleen T Chu
Monitoring mitophagy in neuronal cell cultures.
Methods in molecular biology (Clifton, N.J.) 2011;793():325-39.
2011: Charleen T Chu
Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.
Parkinson's disease 2011;2011():789431.
2010: Salvatore J Cherra; Scott M Kulich; Guy Uechi; Manimalha Balasubramani; John Mountzouris; Billy W Day; Charleen T Chu
Regulation of the autophagy protein LC3 by phosphorylation.
The Journal of cell biology 2010;190(4):533-9.
2010: Charleen T Chu
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.
Human molecular genetics 2010;19(R1):R28-37.
2010: S J Cherra; Ruben K Dagda; Charleen T Chu
Review: autophagy and neurodegeneration: survival at a cost?
Neuropathology and applied neurobiology 2010;36(2):125-32.
2010: David M Bear; Ashley Williams; Charleen T Chu; Christian H Coyle; Constance R Chu
Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(4):546-52.
2010: Constance R Chu; Christian H Coyle; Charleen T Chu; Michal Szczodry; Venkat Seshadri; John C Karpie; Kristina M Cieslak; Elise K Pringle
In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage.
The Journal of bone and joint surgery. American volume 2010;92(3):599-608.
2010: Jianhui Zhu; Charleen T Chu
Mitochondrial dysfunction in Parkinson's disease.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S325-34.
2010: Charleen T Chu
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism.
Biochimica et biophysica acta 2010;1802(1):20-8.
2009: Ruben K Dagda; Charleen T Chu
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.
Journal of bioenergetics and biomembranes 2009;41(6):473-9.
2009: Salvatore J Cherra; Ruben K Dagda; Anurag Tandon; Charleen T Chu
Mitochondrial autophagy as a compensatory response to PINK1 deficiency.
Autophagy 2009;5(8):1213-4.
2009: Ruben K Dagda; Jianhui Zhu; Charleen T Chu
Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models.
Mitochondrion 2009;9(5):289-98.
2009: Craig Horbinski; Sanja Dacic; Roger E McLendon; Kathleen Cieply; Michael Datto; Daniel J Brat; Charleen T Chu
Chordoid glioma: a case report and molecular characterization of five cases.
Brain pathology (Zurich, Switzerland) 2009;19(3):439-48.
2009: Hülya Bayir; Alexandr A Kapralov; Janfei Jiang; Zhentai Huang; Yulia Y Tyurina; Vladimir A Tyurin; Qing Zhao; Natalia A Belikova; Irina I Vlasova; Akihiro Maeda; Jianhui Zhu; Hye-Mee Na; Pier-Giorgio Mastroberardino; Louis J Sparvero; Andrew A Amoscato; Charleen T Chu; J Timothy Greenamyre; Valerian E Kagan
Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease.
The Journal of biological chemistry 2009;284(23):15951-69.
2009: Pier Giorgio Mastroberardino; Eric K Hoffman; Maxx P Horowitz; Ranjita Betarbet; Georgia Taylor; Dongmei Cheng; Hye Mee Na; Claire-Anne Gutekunst; Marla Gearing; John Q Trojanowski; Marjorie Anderson; Charleen T Chu; Junmin Peng; J Timothy Greenamyre
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
Neurobiology of disease 2009;34(3):417-31.
2009: Ruben K Dagda; Salvatore J Cherra; Scott M Kulich; Anurag Tandon; David Park; Charleen T Chu
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
The Journal of biological chemistry 2009;284(20):13843-55.
2009: Lina Du; Robert W Hickey; Hülya Bayir; simon simon watkins; Vladimir A Tyurin; Fengli Guo; Patrick M Kochanek; Larry W Jenkins; Jin Ren; Greg Gibson; Charleen T Chu; Valerian E Kagan; Robert S B Clark
Starving neurons show sex difference in autophagy.
The Journal of biological chemistry 2009;284(4):2383-96.
2009: Laura M Voeghtly; Ida B Thøgersen; Zuzana Valnickova; Kristian W Sanggaard; Charleen T Chu; Tim D Oury; Jan J Enghild
Potential clinical importance of the activation peptide of prostate-specific antigen.
International journal of clinical and experimental pathology 2009;2(6):588-98.
2009: Charleen T Chu; Edward D Plowey; Ruben K Dagda; Robert W Hickey; Salvatore J Cherra; Robert S B Clark
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models.
Methods in enzymology 2009;453():217-49.
2008: Ruben K Dagda; Jianhui Zhu; Scott M Kulich; Charleen T Chu
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease.
Autophagy 2008;4(6):770-82.
2008: Edward D Plowey; Salvatore J Cherra; Yong-Jian Liu; Charleen T Chu
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.
Journal of neurochemistry 2008;105(3):1048-56.
2008: Yichen Lai; Robert W Hickey; Yaming Chen; Hülya Bayir; Mara L Sullivan; Charleen T Chu; Patrick M Kochanek; C Edward Dixon; Larry W Jenkins; Steven H Graham; simon simon watkins; Robert S B Clark
Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):540-50.
2008: Charleen T Chu
Eaten alive: autophagy and neuronal cell death after hypoxia-ischemia.
The American journal of pathology 2008;172(2):284-7.
2008: Robert S B Clark; Hülya Bayir; Charleen T Chu; Sean M Alber; Patrick M Kochanek; simon simon watkins
Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness.
Autophagy 2008;4(1):88-90.
2007: Charleen T Chu; Jianhui Zhu; Ruben Dagda
Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death.
Autophagy 2007;3(6):663-6.
2007: Charleen T Chu; Edward D Plowey; Ying Wang; Vivek Patel; Kelly L Jordan-Sciutto
Location, location, location: altered transcription factor trafficking in neurodegeneration.
Journal of neuropathology and experimental neurology 2007;66(10):873-83.
2007: Scott M Kulich; Craig Horbinski; Manisha Patel; Charleen T Chu
6-Hydroxydopamine induces mitochondrial ERK activation.
Free radical biology & medicine 2007;43(3):372-83.
2007: Kazuya Onuma; Charleen T Chu; David J Dabbs
Asymptomatic giant-cell (temporal) arteritis involving the bilateral adnexa: case report and literature review.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007;26(3):352-5.
2007: Kirill Kiselyov; John J Jennigs; Youssef Rbaibi; Charleen T Chu
Autophagy, mitochondria and cell death in lysosomal storage diseases.
Autophagy 2007;3(3):259-62.
2007: Daoying Hu; Peng Cao; Edda Thiels; Charleen T Chu; Gang-Yi Wu; Tim D Oury; Eric Klann
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase.
Neurobiology of learning and memory 2007;87(3):372-84.
2007: Chenere P Ramsey; Charles A Glass; Marshall B Montgomery; Kathryn A Lindl; Gillian P Ritson; Luis A Chia; Ronald L Hamilton; Charleen T Chu; Kelly L Jordan-Sciutto
Expression of Nrf2 in neurodegenerative diseases.
Journal of neuropathology and experimental neurology 2007;66(1):75-85.
2007: Jian-Hui Zhu; Craig Horbinski; Fengli Guo; Simon Watkins; Yasuo Uchiyama; Charleen T Chu
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death.
The American journal of pathology 2007;170(1):75-86.
2006: John J Jennings; Jian-Hui Zhu; Youssef Rbaibi; Xiang Luo; Charleen T Chu; Kirill Kiselyov
Mitochondrial aberrations in mucolipidosis Type IV.
The Journal of biological chemistry 2006;281(51):39041-50.
2006: Charleen T Chu; D Craig Hooper
Reactive oxygen/nitrogen species at the fulcrum of life-death decisions: a commentary on "peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons".
Free radical biology & medicine 2006;41(11):1629-31.
2006: Valerian E Kagan; Yulia Y Tyurina; Hülya Bayir; Charleen T Chu; Alexandr A Kapralov; Irina I Vlasova; Natalia A Belikova; Vladimir A Tyurin; Andrew A Amoscato; Michael W Epperly; Joel S Greenberger; Steven T DeKosky; Anna A Shvedova; Jianfei Jiang
The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.
Chemico-biological interactions 2006;163(1-2):15-28.
2006: Elisabeth M Chalovich; Jian-Hui Zhu; John Caltagarone; Robert Bowser; Charleen T Chu
Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells.
The Journal of biological chemistry 2006;281(26):17870-81.
2006: Charleen T Chu
Autophagic stress in neuronal injury and disease.
Journal of neuropathology and experimental neurology 2006;65(5):423-32.
2005: Charleen T Chu; Jian-Hui Zhu; Guodong Cao; Armando P Signore; Suping Wang; Jun Chen
Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells.
Journal of neurochemistry 2005;94(6):1685-95.
2005: Jason Callio; Tim D Oury; Charleen T Chu
Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains.
The Journal of biological chemistry 2005;280(18):18536-42.
2005: Craig Horbinski; Charleen T Chu
Kinase signaling cascades in the mitochondrion: a matter of life or death.
Free radical biology & medicine 2005;38(1):2-11.
2004: Charleen T Chu; David J Levinthal; Scott M Kulich; Elisabeth M Chalovich; Donald B DeFranco
Oxidative neuronal injury. The dark side of ERK1/2.
European journal of biochemistry / FEBS 2004;271(11):2060-6.
2004: Maria L Florez-McClure; Daniel A Linseman; Charleen T Chu; Phil A Barker; Ron J Bouchard; Shoshona S Le; Tracey A Laessig; Kim A Heidenreich
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4498-509.
2004: Constance R Chu; Diana Lin; Jessica L Geisler; Charleen T Chu; Freddie H Fu; Yingtian Pan
Arthroscopic microscopy of articular cartilage using optical coherence tomography.
The American journal of sports medicine 2004;32(3):699-709.
2003: Caroline E Hope; Joseph M Mettenburg; Steven L Gonias; Steven T DeKosky; M Ilyas Kamboh; Charleen T Chu
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion.
Neurobiology of disease 2003;14(3):504-12.
2003: Marie E Beckner; John Y K Lee; Sydney S Schochet; Charleen T Chu
Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma: a case report.
Acta neuropathologica 2003;106(6):584-7.
2003: Jian-Hui Zhu; Fengli Guo; John Shelburne; simon simon watkins; Charleen T Chu
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases.
Brain pathology (Zurich, Switzerland) 2003;13(4):473-81.
2003: John A Ozolek; Charleen T Chu
Pseudogout of the craniocervical junction.
Archives of pathology & laboratory medicine 2003;127(7):895.
2003: Scott M Kulich; Charleen T Chu
Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity.
Journal of biosciences 2003;28(1):83-9.
2002: Jian-Hui Zhu; Scott M Kulich; Tim D Oury; Charleen T Chu
Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases.
The American journal of pathology 2002;161(6):2087-98.
2001: Alan M Scarrow; Elad I Levy; Peter C Gerszten; Scott M Kulich; Charleen T Chu; William C Welch
Epidermoid cyst of the thoracic spine: case history.
Clinical neurology and neurosurgery 2001;103(4):220-2.
2001: Cheryl L Fattman; Charleen T Chu; Scott M Kulich; Jan J Enghild; Tim D Oury
Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment.
Free radical biology & medicine 2001;31(10):1198-207.
2001: Scott M Kulich; Charleen T Chu
Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease.
Journal of neurochemistry 2001;77(4):1058-66.
2000: Edda Thiels; Nathaniel Urban; Guillermo Gonzalez-Burgos; Beatriz I Kanterewicz; German Barrionuevo; Charleen T Chu; Tim D Oury; Eric Klann
Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(20):7631-9.
2000: Charleen T Chu; J L Caruso; Thomas J Cummings; John F Ervin; C Rosenberg; Christine M Hulette
Ubiquitin immunochemistry as a diagnostic aid for community pathologists evaluating patients who have dementia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2000;13(4):420-6.
1999: Charleen T Chu; David N Howell; J C Morgenlander; C M Hulette; R E McLendon; S E Miller
Electron microscopic diagnosis of human flavivirus encephalitis: use of confocal microscopy as an aid.
The American journal of surgical pathology 1999;23(10):1217-26.
1999: Thomas J Cummings; Christine M Hulette; DC Longee; Krystal Bottom; Roger E McLendon; Charleen T Chu
Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis.
Clinical neuropathology 1999;18(4):190-7.
1999: L B Goldstein; Charleen T Chu; L Gray; C M Hulette
Angiographically defined primary angiitis of the CNS: is it really benign?
Neurology 1999;52(6):1302; author reply 1302-3.
1999: Thomas J Cummings; Charleen T Chu; C M Hulette
December 1998--16 year old female with headaches, lethargy and a sellar/suprasellar mass.
Brain pathology (Zurich, Switzerland) 1999;9(2):425-6.
1998: Charleen T Chu; L Gray; L B Goldstein; Christine M Hulette
Diagnosis of intracranial vasculitis: a multi-disciplinary approach.
Journal of neuropathology and experimental neurology 1998;57(1):30-8.
1997: Charleen T Chu; K D Everiss; Carol J Wikstrand; Surinder Batra; Hsing-Jien Kung; D D Bigner
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
The Biochemical journal 1997;324 ( Pt 3)():855-61.
1996: Zuzana Valnickova; IB Thogersen; S Christensen; Charleen T Chu; Salvatore V Pizzo; Jan J Enghild
Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.
The Journal of biological chemistry 1996;271(22):12937-43.
1996: W D Bradford; D Anthony; Charleen T Chu; Salvatore V Pizzo
Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990.
Academic medicine : journal of the Association of American Medical Colleges 1996;71(5):484-7.
1995: Xiang-dong D Ren; Alister W Dodds; Jan J Enghild; Charleen T Chu; S K Alex Law
The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3.
FEBS letters 1995;368(1):87-91.
1994: Charleen T Chu; Salvatore V Pizzo
alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation.
Laboratory investigation; a journal of technical methods and pathology 1994;71(6):792-812.
1994: Charleen T Chu; G C Howard; Uma Kant Misra; Salvatore V Pizzo
Alpha 2-macroglobulin: a sensor for proteolysis.
Annals of the New York Academy of Sciences 1994;737():291-307.
1994: Uma Kant Misra; Charleen T Chu; Govind Gawdi; Salvatore V Pizzo
The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.
The Journal of biological chemistry 1994;269(28):18303-6.
1994: Uma Kant Misra; Charleen T Chu; Govind Gawdi; Salvatore V Pizzo
Evidence for a second alpha 2-macroglobulin receptor.
The Journal of biological chemistry 1994;269(17):12541-7.
1994: Charleen T Chu; Tim D Oury; Jan J Enghild; Salvatore V Pizzo
Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1538-45.
1993: Uma Kant Misra; Charleen T Chu; David S Rubenstein; Govind Gawdi; Salvatore V Pizzo
Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.
The Biochemical journal 1993;290 ( Pt 3)():885-91.
1993: Charleen T Chu; Salvatore V Pizzo
Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):48-58.
1991: Charleen T Chu; David S Rubenstein; Jan J Enghild; Salvatore V Pizzo
Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding.
Biochemistry 1991;30(6):1551-60.