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Yang-Sook Chun

Research Profile

Chemicals & Drugs

Physiology

Cell Hypoxia

Anatomy

Living Beings

Procedures

Reverse Transcriptase Polymerase Chain Reaction

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TOP 3
Kumsun Cho; Yang-Sook Chun; Tae-You Kim; Young-Im Kim; Chung-Hyun Cho; Hyun-Woo Shin; Jong-Wan Park
Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function.
Hyoung-Sook Park; Jong-Wan Park; Chang Won Choi; Byung Il Kim; Hye-Jin Kim; Hyun-Ju Lee; Yang-Sook Chun
Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway.
Hye-Jin Kim; Ji-Seon Kim; Sang Jeong Kim; Jong-Wan Park; Hyun-Woo Shin; Chung-Hyun Cho; Young-Suk Cho; Doo Hyun Chung; Yang-Sook Chun
Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation.

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All Publications

2013: Kumsun Cho; Yang-Sook Chun; Tae-You Kim; Young-Im Kim; Chung-Hyun Cho; Hyun-Woo Shin; Jong-Wan Park
Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function.
Free radical biology & medicine 2013;60():201-10.
2013: Hyoung-Sook Park; Jong-Wan Park; Chang Won Choi; Byung Il Kim; Hye-Jin Kim; Hyun-Ju Lee; Yang-Sook Chun
Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway.
American journal of respiratory cell and molecular biology 2013;48(1):105-13.
2013: Hye-Jin Kim; Ji-Seon Kim; Sang Jeong Kim; Jong-Wan Park; Hyun-Woo Shin; Chung-Hyun Cho; Young-Suk Cho; Doo Hyun Chung; Yang-Sook Chun
Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation.
Biochimica et biophysica acta 2013;1832(1):183-94.
2012: Jung-Soo Bae; Shan-Hua Li; Hyoung-Sook Park; Jong-Wan Park; Yang-Sook Chun
Red ginseng and 20(S)-Rg3 control testosterone-induced prostate hyperplasia by deregulating androgen receptor signaling.
Journal of natural medicines 2012;66(3):476-85.
2011: Chun Zi Jin; HS Kim; Yang-Sook Chun; Kyung Sun Park; Eun Yeong Seo; Dong Hoon Shin; Yin Hua Zhang; Sung Joon Kim
Exercise training increases inwardly rectifying K(+) current and augments K(+)-mediated vasodilatation in deep femoral artery of rats.
Cardiovascular research 2011;91(1):142-50.
2011: Shan Hua Li; Yang-Sook Chun; Ji-Hong Lim; L Eric Huang; Jong-Wan Park
von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase.
The international journal of biochemistry & cell biology 2011;43(5):795-804.
2011: Yoon-Mi Lee; Ji-Hong Lim; Haejin Yoon; Yang-Sook Chun; Jong-Wan Park
Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro.
Hepatology (Baltimore, Md.) 2011;53(1):171-80.
2010: Hyunsung Choi; Yang-Sook Chun; Tae-You Kim; Jong-Wan Park
HIF-2alpha enhances beta-catenin/TCF-driven transcription by interacting with beta-catenin.
Cancer research 2010;70(24):10101-11.
2010: Shan-Hua Li; Ji-Hye Ryu; Sook-Eun Park; Young-Suk Cho; Jong-Wan Park; Wang Jae Lee; Yang-Sook Chun
Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha.
The Journal of nutritional biochemistry 2010;21(9):801-8.
2010: Young-Joo Yun; Shan-Hua Li; Young-Suk Cho; Jong-Wan Park; Yang-Sook Chun
Survivin mediates prostate cell protection by HIF-1alpha against zinc toxicity.
The Prostate 2010;70(11):1179-88.
2010: Ji-Hong Lim; Yoon-Mi Lee; Yang-Sook Chun; Junjie Chen; Ja-Eun Kim; Jong-Wan Park
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
Molecular cell 2010;38(6):864-78.
2009: Yoon-Mi Lee; Ji-Hong Lim; Yang-Sook Chun; Hyo-Eun Moon; Myung Kyu Lee; L Eric Huang; Jong-Wan Park
Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha.
Carcinogenesis 2009;30(10):1768-75.
2009: Su Jung Park; Yang-Sook Chun; Kyung Sun Park; Sung Joon Kim; Si-On Choi; Hye-Lim Kim; Jong-Wan Park
Identification of subdomains in NADPH oxidase-4 critical for the oxygen-dependent regulation of TASK-1 K+ channels.
American journal of physiology. Cell physiology 2009;297(4):C855-64.
2009: Byung Yoon Choi; Andrew K Stewart; Katherine K Nishimura; Won Jae Cha; Moon-Woo Seong; Sung Sup Park; Seung Won Kim; Yang-Sook Chun; Jong Woo Chung; Shi-Nae Park; Sun O Chang; Chong-Sun Kim; Seth L Alper; Andrew J Griffith; Seung-Ha Oh
Efficient molecular genetic diagnosis of enlarged vestibular aqueducts in East Asians.
Genetic testing and molecular biomarkers 2009;13(5):679-87.
2009: Haifeng Zheng; Joo Hyun Nam; Bo Pang; Dong Hoon Shin; Ji Seon Kim; Yang-Sook Chun; Jong-Wan Park; Hyowon Bang; Woo Kyung Kim; Yung E Earm; Sung Joon Kim
Identification of the large-conductance background K+ channel in mouse B cells as TREK-2.
American journal of physiology. Cell physiology 2009;297(1):C188-97.
2009: Ji-Seon Kim; Haifeng Zheng; Sung Joon Kim; Jong-Wan Park; Kyong Soo Park; Won-Kyung Ho; Yang-Sook Chun
Role of aryl hydrocarbon receptor nuclear translocator in KATP channel-mediated insulin secretion in INS-1 insulinoma cells.
Biochemical and biophysical research communications 2009;379(4):1048-53.
2009: Hye-Lim Kim; Young-Suk Cho; Hong Choi; Yang-Sook Chun; Zang Hee Lee; Jong-Wan Park
Hypoxia-inducible factor 1alpha is deregulated by the serum of rats with adjuvant-induced arthritis.
Biochemical and biophysical research communications 2009;378(1):123-8.
2009: Dong Hoon Shin; Yang-Sook Chun; Kyoung-Hwa Lee; Hyun-Woo Shin; Jong-Wan Park
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.
PloS one 2009;4(10):e7451.
2008: Ji-Hong Lim; Yoon-Mi Lee; Yang-Sook Chun; Jong-Wan Park
Reactive oxygen species-mediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor.
Cancer science 2008;99(9):1798-805.
2008: Ji-Hong Lim; Yang-Sook Chun; Jong-Wan Park
Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin.
Cancer research 2008;68(13):5177-84.
2008: D H Shin; S H Li; Yang-Sook Chun; L Eric Huang; Myung-Suk Kim; Jong-Wan Park
CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition.
Oncogene 2008;27(13):1939-44.
2008: Dong Hoon Shin; Yang-Sook Chun; Dong Soon Lee; L Eric Huang; Jong-Wan Park
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.
Blood 2008;111(6):3131-6.
2008: Ji-Hye Ryu; Young-Suk Cho; Yang-Sook Chun; Jong-Wan Park
Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury.
Biochemical and biophysical research communications 2008;366(2):438-44.
2008: Young-Suk Cho; Jae-Moon Bae; Yang-Sook Chun; Jin-Ho Chung; Yoon-Kyung Jeon; In-San Kim; Myung-Suk Kim; Jong-Wan Park
HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1).
Biochimica et biophysica acta 2008;1783(2):323-33.
2008: Kyung-Eun Kim; Yu-Jung Jung; Shan Hua Li; Yang-Sook Chun; Curie Ahn; Jong-Wan Park
Cloning of miniature pig HIF-1alpha and its responses to immunosuppressive agents.
Immunopharmacology and immunotoxicology 2008;30(1):105-15.
2007: Sook-Eun Park; Jong-Wan Park; Young-Suk Cho; Ji-Hye Ryu; Jae-Seung Paick; Yang-Sook Chun
HIF-1alpha promotes survival of prostate cells at a high zinc environment.
The Prostate 2007;67(14):1514-23.
2007: Dong Hoon Shin; Jin-Ho Kim; Yu-Jung Jung; Kyung-Eun Kim; Jae Min Jeong; Yang-Sook Chun; Jong-Wan Park
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading.
Cancer letters 2007;255(1):107-16.
2007: Ji-Hong Lim; Jong-Wan Park; Sung Joon Kim; Myung-Suk Kim; Sang-Ki Park; Randall S Johnson; Yang-Sook Chun
ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.
Molecular pharmacology 2007;71(3):942-8.
2006: Ji-Hong Lim; Jong-Wan Park; Myung-Suk Kim; Sang-Ki Park; Randall S Johnson; Yang-Sook Chun
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.
Molecular pharmacology 2006;70(6):1856-65.
2006: Ji-Hong Lim; Jong-Wan Park; Yang-Sook Chun
Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation.
Cancer research 2006;66(22):10677-82.
2006: Hyunsung Choi; Yang-Sook Chun; Seung-Won Kim; Myung-Suk Kim; Jong-Wan Park
Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition.
Molecular pharmacology 2006;70(5):1664-71.
2006: Hye-Lim Kim; Eun-Jin Yeo; Yang-Sook Chun; Jong-Wan Park
A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent.
International journal of oncology 2006;29(1):255-60.
2006: Eun-Jin Yeo; Ji-Hye Ryu; Yang-Sook Chun; Young-Suk Cho; In-Jin Jang; HoSung Cho; Jinho Kim; Myung-Suk Kim; Jong-Wan Park
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Cancer research 2006;66(12):6345-52.
2006: Hong Choi; Sang-Hyun Kim; Yang-Sook Chun; Young-Suk Cho; Jong-Wan Park; Myung-Suk Kim
In vivo hyperoxic preconditioning prevents myocardial infarction by expressing bcl-2.
Experimental biology and medicine (Maywood, N.J.) 2006;231(4):463-72.
2006: Young-Mee Lee; Byung-Joo Kim; Yang-Sook Chun; Insuk So; Hyunsung Choi; Myung-Suk Kim; Jong-Wan Park
NOX4 as an oxygen sensor to regulate TASK-1 activity.
Cellular signalling 2006;18(4):499-507.
2006: Eun-Jin Yeo; Ji-Hye Ryu; Young-Suk Cho; Yang-Sook Chun; L Eric Huang; Myung-Suk Kim; Jong-Wan Park
Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.
Blood 2006;107(3):916-23.
2006: Kyoung-Hwa Lee; Eunjoo Choi; Yang-Sook Chun; Myung-Suk Kim; Jong-Wan Park
Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency.
Biochimie 2006;88(2):163-9.
2006: Kyung-Eun Kim; Yu-Jung Jung; Eun-Jin Yeo; Yang-Sook Chun; Jong-Wan Park
FK506: an immunosuppressive agent preserving HIF-1 activity.
Immunopharmacology and immunotoxicology 2006;28(4):609-20.
2005: Kyuheun Kim; Ji-Hye Ryu; Jong-Wan Park; Myung-Suk Kim; Yang-Sook Chun
Induction of a SSAT isoform in response to hypoxia or iron deficiency and its protective effects on cell death.
Biochemical and biophysical research communications 2005;331(1):78-85.
2004: Ji-Hong Lim; Eun-Seo Lee; Ho-Jin You; Jung Weon Lee; Jong-Wan Park; Yang-Sook Chun
Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion.
Oncogene 2004;23(58):9427-31.
2004: Yang-Sook Chun; Eun-Jin Yeo; Hwa-Jin Suh; Jong-Wan Park
Spontaneous generation of reactive oxygen species in the mixture of cyanide and glycerol.
Annals of the New York Academy of Sciences 2004;1030():43-51.
2004: Eun-Jin Yeo; Yang-Sook Chun; Jong-Wan Park
New anticancer strategies targeting HIF-1.
Biochemical pharmacology 2004;68(6):1061-9.
2004: Ju-Yeon Hyun; Yang-Sook Chun; Tae-You Kim; Hye-Lim Kim; Myung-Suk Kim; Jong-Wan Park
Hypoxia-inducible factor 1alpha- mediated resistance to phenolic anticancer.
Chemotherapy 2004;50(3):119-26.
2004: Yang-Sook Chun; Eun-Jin Yeo; Jong-Wan Park
Versatile pharmacological actions of YC-1: anti-platelet to anticancer.
Cancer letters 2004;207(1):1-7.
2004: Jong-Wan Park; Yang-Sook Chun; Myung-Suk Kim
Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.
Journal of pharmacological sciences 2004;94(3):221-32.
2004: Kyoung-Hwa Lee; Jong-Wan Park; Yang-Sook Chun
Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1alpha isoform.
Nucleic acids research 2004;32(18):5499-511.
2003: Yang-Sook Chun; Kyoung-Hwa Lee; Eunjoo Choi; Soo-Young Bae; Eun-Jin Yeo; L Eric Huang; Myung-Suk Kim; Jong-Wan Park
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion.
Cancer research 2003;63(24):8700-7.
2003: Gi-Tae Kim; Yang-Sook Chun; Jong-Wan Park; Myung-Suk Kim
Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion.
Biochemical and biophysical research communications 2003;309(3):619-24.
2003: Eun-Jin Yeo; Yang-Sook Chun; Young-Suk Cho; Jinho Kim; June-Chul Lee; Myung-Suk Kim; Jong-Wan Park
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Journal of the National Cancer Institute 2003;95(7):516-25.
2003: Yang-Sook Chun; Ju-Yeon Hyun; Yong-Geun Kwak; In-San Kim; Chan-Hyung Kim; Eunjoo Choi; Myung-Suk Kim; Jong-Wan Park
Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1.
The Biochemical journal 2003;370(Pt 1):149-57.
2003: Jung-Hyun Park; Tae-You Kim; Hyun-Soon Jong; Tae-You Kim; Yang-Sook Chun; Jong-Wan Park; Choon-Taek Lee; Hyun Chae Jung; Noe Kyeong Kim; Yung-Jue Bang
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):433-40.
2002: Yang-Sook Chun; Myung-Suk Kim; Jong-Wan Park
Oxygen-dependent and -independent regulation of HIF-1alpha.
Journal of Korean medical science 2002;17(5):581-8.
2002: Young-Hoon Kim; Yang-Sook Chun; Jong-Wan Park; Chan-Hyung Kim; Myung-Suk Kim
Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(5):R1450-8.
2002: Yang-Sook Chun; Eunjoo Choi; Tae-You Kim; Myung-Suk Kim; Jong-Wan Park
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene.
The Biochemical journal 2002;362(Pt 1):71-9.
2002: Chan-Hyung Kim; Young-Suk Cho; Yang-Sook Chun; Jong-Wan Park; Myung-Suk Kim
Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway.
Circulation research 2002;90(2):E25-33.
2001: Yang-Sook Chun; E J Yeo; E Choi; C M Teng; J M Bae; Myung-Suk Kim; Jong-Wan Park
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
Biochemical pharmacology 2001;61(8):947-54.
2000: Yang-Sook Chun; E Choi; G T Kim; H Choi; C H Kim; MJ Lee; Myung-Suk Kim; Jong-Wan Park
Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha.
European journal of biochemistry / FEBS 2000;267(13):4198-204.
2000: Yang-Sook Chun; E Choi; G T Kim; MJ Lee; M J Lee; S E Lee; Myung-Suk Kim; Jong-Wan Park
Zinc induces the accumulation of hypoxia-inducible factor (HIF)-1alpha, but inhibits the nuclear translocation of HIF-1beta, causing HIF-1 inactivation.
Biochemical and biophysical research communications 2000;268(2):652-6.