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Denise Chung

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Chemicals & Drugs

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Publications

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Mecheal Kanovsky; Josef Michl; Georgia Botzolaki; Joseph Morin; Cecilia Kovac; Denise L Chung; Lyndon Chie; Fred Friedman; Matthew R Pincus
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Denise Way; Steven Smith; Sharmila Sivendran; Lyndon Chie; Mecheal Kanovsky; Paul W Brandt-Rauf; Denise L Chung; Josef Michl; Matthew R Pincus
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Cecilia Kovac; L Clie; J Morin; Fred Friedman; Richard Robinson; Denise L Chung; Mecheal Kanovsky; J Flom; Paul W Brandt-Rauf; Ziro Yamaizumi; Josef Michl; Matthew R Pincus
Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation.

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All Publications

2003: Mecheal Kanovsky; Josef Michl; Georgia Botzolaki; Joseph Morin; Cecilia Kovac; Denise L Chung; Lyndon Chie; Fred Friedman; Matthew R Pincus
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Cancer chemotherapy and pharmacology 2003;52(3):202-8.
2002: Denise Way; Steven Smith; Sharmila Sivendran; Lyndon Chie; Mecheal Kanovsky; Paul W Brandt-Rauf; Denise L Chung; Josef Michl; Matthew R Pincus
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Cancer chemotherapy and pharmacology 2002;49(6):429-37.
2001: Cecilia Kovac; L Clie; J Morin; Fred Friedman; Richard Robinson; Denise L Chung; Mecheal Kanovsky; J Flom; Paul W Brandt-Rauf; Ziro Yamaizumi; Josef Michl; Matthew R Pincus
Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation.
Cancer chemotherapy and pharmacology 2001;48(1):9-14.
2000: Lyndon Chie; S Amar; Hsiang-Fu Kung; M C Lin; H Chen; Denise L Chung; Victor Adler; Ze'ev Ronai; Fred Friedman; Richard C Robinson; Cecilia Kovac; Paul W Brandt-Rauf; Ziro Yamaizumi; Josef Michl; Matthew R Pincus
Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.
Cancer chemotherapy and pharmacology 2000;45(6):441-9.
2000: A Villafania; K Anwar; S Amar; Lyndon Chie; D Way; Denise L Chung; Victor Adler; Ze'ev Ronai; Paul W Brandt-Rauf; Z Yamaizumii; Hsiang-Fu Kung; Matthew R Pincus
Glutathione-S-Transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase.
Annals of clinical and laboratory science 2000;30(1):57-64.
1999: Lyndon Chie; James M Chen; Fred Friedman; Denise L Chung; S Amar; Josef Michl; Ziro Yamaizumi; Paul W Brandt-Rauf; Matthew R Pincus
Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain.
Journal of protein chemistry 1999;18(8):881-4.
1999: Lyndon Chie; James M Chen; Fred Friedman; Denise L Chung; S Amar; Josef Michl; Ziro Yamaizumi; Paul W Brandt-Rauf; Matthew R Pincus
Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21.
Journal of protein chemistry 1999;18(8):875-9.
1992: Denise L Chung; A Joran; F Friedman; R Robinson; Paul W Brandt-Rauf; I Bernard Weinstein; Ze'ev Ronai; L Baskin; D C Dykes; R B Murphy
Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms.
Experimental cell research 1992;203(2):329-35.
1992: Denise L Chung; Paul W Brandt-Rauf; I Bernard Weinstein; S Nishimura; Ziro Yamaizumi; R B Murphy; Matthew R Pincus
Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1993-6.
1991: Denise L Chung; Paul W Brandt-Rauf; R B Murphy; S Nishimura; Ziro Yamaizumi; I Bernard Weinstein; Matthew R Pincus
A peptide from the GAP-binding domain of the ras-p21 protein as well as azatyrosine block ras-induced maturation of Xenopus oocytes.
Biochemical and biophysical research communications 1991;181(3):1378-84.
1991: Denise L Chung; Paul W Brandt-Rauf; R B Murphy; S Nishimura; Ziro Yamaizumi; I Bernard Weinstein; Matthew R Pincus
A peptide from the GAP-binding domain of the ras-p21 protein and azatyrosine block ras-induced maturation of Xenopus oocytes.
Anticancer research 1991;11(4):1373-8.