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Stephen Chung
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Chemicals & Drugs
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Network (preview)
37
Chung, Sookja
14
Ko, Ben
9
Lo, Amy
6
Lam, Karen
4
Jiang, Zhirong
3
Ho, Hudson
3
Ho, Maggie
3
Fung, Maggie
3
Cao, Deliang
3
Cheung, Alvin
3
Lam, Amy
3
Tsang, Margaret
3
Tam, Sidney
3
Yang, James
3
Lee, Alan
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All Publications
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2009: Leung Justin W C; Chung Stephen S M; Chung Sookja K
Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion.
Brain research 2009;1266():121-9.
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2008: Chan Alfred W H; Ho Ye-shih; Chung Sookja K; Chung Stephen S M
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.
Experimental eye research 2008;87(5):454-61.
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2008: Qiu Longxin; Wu Xiaochun; Chau Jenny F L; Szeto Irene Y Y; Tam Wing Yip; Guo Zongsheng; Chung Sookja K; Oates Peter J; Chung Stephen S M; Yang James Y
Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis.
The Journal of biological chemistry 2008;283(25):17175-83.
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2008: Xu SongXiao; Wong Catherine C L; Tong Edith H Y; Chung Stephen S M; Yates John R; Yin YiBing; Ko Ben C B
Phosphorylation by casein kinase 1 regulates tonicity-induced osmotic response element-binding protein/tonicity enhancer-binding protein nucleocytoplasmic trafficking.
The Journal of biological chemistry 2008;283(25):17624-34.
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2007: Cheung Alvin K H; Lo Amy C Y; So Kwok Fai; Chung Stephen S M; Chung Sookja K
Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury.
Experimental eye research 2007;85(5):608-16.
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2007: Lo Amy C Y; Cheung Alvin K H; Hung Victor K L; Yeung Chung-Man; He Qing-Yu; Chiu Jen-Fu; Chung Stephen S M; Chung Sookja K
Deletion of aldose reductase leads to protection against cerebral ischemic injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(8):1496-509.
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2007: Ho H T B; Ko B C B; Cheung A K H; Lam A K M; Tam S; Chung S K; Chung S S M
Generation and characterization of sodium-dicarboxylate cotransporter-deficient mice.
Kidney international 2007;72(1):63-71.
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2007: Li Hongyan; Fung King-Leung; Jin Dong-Yan; Chung Stephen S M; Ching Yick-Pang; Ng Irene Oi-lin; Sze Kong-Hung; Ko Ben C B; Sun Hongzhe
Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2.
Proteins 2007;67(4):1154-66.
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2006: Huang Ping; Jiang Zhirong; Teng Shuzhi; Wong Y C; Frohman Michael A; Chung Sookja K; Chung Stephen S M
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress.
Experimental eye research 2006;83(4):939-48.
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2006: Tong Edith H Y; Guo Jin-Jun; Huang Ai-Long; Liu Han; Hu Chang-Deng; Chung Stephen S M; Ko Ben C B
Regulation of nucleocytoplasmic trafficking of transcription factor OREBP/TonEBP/NFAT5.
The Journal of biological chemistry 2006;281(33):23870-9.
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2006: Ho Eric C M; Lam Karen S L; Chen Yuk Shan; Yip Johnny C W; Arvindakshan Meena; Yamagishi Shin-Ichiro; Yagihashi Soroku; Oates Peter J; Ellery Craig A; Chung Stephen S M; Chung Sookja K
Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.
Diabetes 2006;55(7):1946-53.
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2006: Yang James Y; Tam W Y; Tam Sidney; Guo Hong; Wu Xiaochun; Li Guohua; Chau Jenny F L; Klein Janet D; Chung Sookja K; Sands Jeff M; Chung Stephen S M
Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism.
American journal of physiology. Renal physiology 2006;291(1):F186-95.
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2006: Li Gui-Rong; Deng Xiu-Ling; Sun Haiying; Chung Stephen S M; Tse Hung-Fat; Lau Chu-Pak
Ion channels in mesenchymal stem cells from rat bone marrow.
Stem cells (Dayton, Ohio) 2006;24(6):1519-28.
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2005: Cheung Alvin K H; Fung Maggie K L; Lo Amy C Y; Lam Terence T L; So Kwok Fai; Chung Stephen S M; Chung Sookja K
Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.
Diabetes 2005;54(11):3119-25.
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2005: Chen Yuk Shan; Chung Stephen S M; Chung Sookja K
Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice.
Diabetes 2005;54(11):3112-8.
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2005: Tsang Margaret C S; Lo Amy C Y; Chan Theobald S K; Chung Stephen S M; Chung Sookja K
Expression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinatal mouse brains.
The International journal of neuroscience 2005;115(11):1485-501.
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2005: Chau Jenny F L; Lee M K; Law Janice W S; Chung Sookja K; Chung Stephen S M
Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1887-9.
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2005: Wong Vincent K W; Chiu Pauline; Chung Stephen S M; Chow Larry M C; Zhao Yun-Zhe; Yang Burton B; Ko Ben C B
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):6002-11.
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2005: Lo Amy C Y; Chen Ann Y S; Hung Victor K L; Yaw Lai Ping; Fung Maggie K L; Ho Maggie C Y; Tsang Margaret C S; Chung Stephen S M; Chung Sookja K
Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(8):998-1011.
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2005: Chung S S M; Chung S K
Aldose reductase in diabetic microvascular complications.
Current drug targets 2005;6(4):475-86.
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2005: Wang Yu; Ko Ben C B; Yang James Y; Lam Terrence T L; Jiang Zhirong; Zhang Jinsong; Chung Sookja K; Chung Stephen S M
Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.
The Journal of biological chemistry 2005;280(20):19986-91.
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2004: Dan Qinghong; Wong Rachel; Chung Sookja K; Chung Stephen S M; Lam Karen S L
Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion.
Life sciences 2004;76(4):445-59.
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2004: Leung Justin W C; Ho Maggie C Y; Lo Amy C Y; Chung Stephen S M; Chung Sookja K
Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S293-300.
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2004: Lam Amy K M; Ko Ben C B; Tam Sidney; Morris Ryan; Yang James Y; Chung Sookja K; Chung Stephen S M
Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.
The Journal of biological chemistry 2004;279(46):48048-54.
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2004: Li Zhibin; Liao Chenzhong; Ko Ben C B; Shan Song; Tong Edith H Y; Yin Zihui; Pan Desi; Wong Vincent K W; Shi Leming; Ning Zhi-Qiang; Hu Weiming; Zhou Jiaju; Chung Stephen S M; Lu Xian-Ping
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.
Bioorganic & medicinal chemistry letters 2004;14(13):3507-11.
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2004: Lo Amy C Y; Fung Maggie K L; Au C L; Chan Theobald S K; Sauer Brian; Chung Stephen S M; Chung Sookja K
Transgenic mice over-expressing endothelin-1 in testis transactivated by a Cre/loxP system showed decreased testicular capillary blood flow.
Transgenic research 2004;13(2):119-34.
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2004: Dan Qinghong; Wong Rachel L C; Yin Shinan; Chung Sookja K; Chung Stephen S M; Lam Karen S L
Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression.
Nephron. Experimental nephrology 2004;98(3):e89-99.
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2003: Song Zhentao; Fu Douglas T W; Chan Ying-Shing; Leung Suetyi; Chung Stephen S M; Chung Sookja K
Transgenic mice overexpressing aldose reductase in Schwann cells show more severe nerve conduction velocity deficit and oxidative stress under hyperglycemic stress.
Molecular and cellular neurosciences 2003;23(4):638-47.
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2003: Chung Stephen S M; Ho Eric C M; Lam Karen S L; Chung Sookja K
Contribution of polyol pathway to diabetes-induced oxidative stress.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S233-6.
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2003: Chung S S M; Chung S K
Genetic analysis of aldose reductase in diabetic complications.
Current medicinal chemistry 2003;10(15):1375-87.
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2002: Ko Ben C B; Lam Amy K M; Kapus Andras; Fan Lingzhi; Chung Sookja K; Chung Stephen S M
Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).
The Journal of biological chemistry 2002;277(48):46085-92.
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2002: Liu Y F; Wat N M S; Chung S S M; Ko B C B; Lam K S L
Diabetic nephropathy is associated with the 5'-end dinucleotide repeat polymorphism of the aldose reductase gene in Chinese subjects with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(2):113-8.
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2001: Tsang M C; Lo A C; Cheung P T; Chung S S; Chung S K
Perinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells.
Neuroreport 2001;12(10):2265-70.
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2001: Ho M C; Lo A C; Kurihara H; Yu A C; Chung S S; Chung S K
Endothelin-1 protects astrocytes from hypoxic/ischemic injury.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):618-26.
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2001: Lee K W; Ko B C; Jiang Z; Cao D; Chung S S
Overexpression of aldose reductase in liver cancers may contribute to drug resistance.
Anti-cancer drugs 2001;12(2):129-32.
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2000: Ho H T; Chung S K; Law J W; Ko B C; Tam S C; Brooks H L; Knepper M A; Chung S S
Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.
Molecular and cellular biology 2000;20(16):5840-6.
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2000: Jiang Z; Chung S K; Zhou C; Cammarata P R; Chung S S
Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract.
Investigative ophthalmology & visual science 2000;41(6):1467-72.
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2000: Ko B C; Turck C W; Lee K W; Yang Y; Chung S S
Purification, identification, and characterization of an osmotic response element binding protein.
Biochemical and biophysical research communications 2000;270(1):52-61.
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1999: Yeung C M; Wong C K; Chung S K; Chung S S; Chow B K
Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining.
Molecular and cellular endocrinology 1999;154(1-2):161-70.
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1999: Ho H T; Jenkins N A; Copeland N G; Gilbert D J; Winkles J A; Louie H W; Lee F K; Chung S S; Chung S K
Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.
European journal of biochemistry / FEBS 1999;259(3):726-30.
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1999: Lee A Y; Chung S S
Contributions of polyol pathway to oxidative stress in diabetic cataract.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):23-30.
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1998: Ng T F; Lee F K; Song Z T; Calcutt N A; Lee A Y; Chung S S; Chung S K;
Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.
Diabetes 1998;47(6):961-6.
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1998: Cao D; Fan S T; Chung S S
Identification and characterization of a novel human aldose reductase-like gene.
The Journal of biological chemistry 1998;273(19):11429-35.
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1998: Lee A Y; Chung S S
Involvement of aldose reductase in naphthalene cataract.
Investigative ophthalmology & visual science 1998;39(1):193-7.
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1997: Lee F K; Chung S K; Chung S S
Aberrant mRNA splicing causes sorbitol dehydrogenase deficiency in C57BL/LiA mice.
Genomics 1997;46(1):86-92.
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1997: Ko B C; Ruepp B; Bohren K M; Gabbay K H; Chung S S
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.
The Journal of biological chemistry 1997;272(26):16431-7.
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1995: Chan T S; Lin C X; Chan W Y; Chung S S; Chung S K
Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development.
European journal of biochemistry / FEBS 1995;234(3):819-26.
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1995: Lau E T; Cao D; Lin C; Chung S K; Chung S S
Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.
The Biochemical journal 1995;312 ( Pt 2)():609-15.
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1995: Ko B C; Lam K S; Wat N M; Chung S S
An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients.
Diabetes 1995;44(7):727-32.
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1995: Lee F K; Lee A Y; Lin C X; Chung S S; Chung S K
Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA.
European journal of biochemistry / FEBS 1995;230(3):1059-65.
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1995: Lee A Y; Chung S K; Chung S S
Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2780-4.
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