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Georg Alfthan

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P P Söderholm; Herman Adlercreutz; Georg Alfthan; A H Koskela; Matti J Tikkanen
The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals.
P P Söderholm; Matti J Tikkanen; Georg Alfthan; Herman Adlercreutz
Rye bread intake improves oxidation resistance of LDL in healthy humans.
M Prasad; H-M Takkinen; J Nevalainen; M-L Ovaskainen; Georg Alfthan; Liisa Uusitalo; Mike Kenward; Riitta Veijola; Olli Simell; Jorma Ilonen; Mikael Knip; Suvi M Virtanen
Are serum α- and β-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes?

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All Publications

2012: P P Söderholm; Herman Adlercreutz; Georg Alfthan; A H Koskela; Matti J Tikkanen
The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2012;22(7):575-82.
2012: P P Söderholm; Matti J Tikkanen; Georg Alfthan; Herman Adlercreutz
Rye bread intake improves oxidation resistance of LDL in healthy humans.
Atherosclerosis 2012;221(2):583-6.
2011: M Prasad; H-M Takkinen; J Nevalainen; M-L Ovaskainen; Georg Alfthan; Liisa Uusitalo; Mike Kenward; Riitta Veijola; Olli Simell; Jorma Ilonen; Mikael Knip; Suvi M Virtanen
Are serum α- and β-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes?
Diabetes & metabolism 2011;37(2):162-7.
2010: Hannu Päivä; Mika Kähönen; Terho Lehtimäki; Georg Alfthan; Jorma Viikari; Reijo Laaksonen; Nina Hutri-Kähönen; Tomi Laitinen; Leena Taittonen; Olli T Raitakari; Markus Juonala
Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis 2010;212(2):512-5.
2010: Raika Koli; Iris Erlund; Antti Jula; Jukka Marniemi; Pirjo Mattila; Georg Alfthan
Bioavailability of various polyphenols from a diet containing moderate amounts of berries.
Journal of agricultural and food chemistry 2010;58(7):3927-32.
2010: Pirjo Valtonen; Kari Punnonen; Heli Saarelainen; Nonna Heiskanen; Olli T Raitakari; Markus Juonala; Jorma S A Viikari; Georg Alfthan; Mika Kähönen; Reijo Laaksonen; Tiina Lyyra-Laitinen; Tomi Laitinen; Seppo Heinonen
ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study.
European journal of endocrinology / European Federation of Endocrine Societies 2010;162(2):259-65.
2009: Kati Hyvärinen; Anita M Tuomainen; Saara Laitinen; Igor L Bykov; Liisa Törmäkangas; Kai Lindros; Reijo Kakela; Georg Alfthan; Irma Salminen; Matti Jauhiainen; Petri T Kovanen; Maija Leinonen; Pekka Saikku; Pirkko J Pussinen
Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Infection and immunity 2009;77(8):3442-9.
2009: Laura Lakio; JP Antinheimo; Susanna Paju; Kåre Buhlin; Pirkko J Pussinen; Georg Alfthan
Tracking of plasma antibodies against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis during 15 years.
Journal of oral microbiology 2009;1():.
2008: Jouko Sundvall; Tiina Laatikainen; Samu Hakala; Jaana Leiviskä; Georg Alfthan
Systematic error of serum triglyceride measurements during three decades and the effect of fasting on serum triglycerides in population studies.
Clinica chimica acta; international journal of clinical chemistry 2008;397(1-2):55-9.
2008: Hannu Päivä; Mika Kähönen; Terho Lehtimäki; Olli T Raitakari; Antti Jula; Jorma Viikari; Georg Alfthan; Markus Juonala; Reijo Laaksonen; Nina Hutri-Kähönen
Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.
American journal of hypertension 2008;21(8):873-8.
2008: Irma Salminen; Georg Alfthan
Plasma ascorbic acid preparation and storage for epidemiological studies using TCA precipitation.
Clinical biochemistry 2008;41(9):723-7.
2008: Liisa Uusitalo; Juha Nevalainen; S Niinistö; Georg Alfthan; Jouko Sundvall; T Korhonen; Mike Kenward; H Oja; Riitta Veijola; Olli Simell; Jorma Ilonen; Mikael Knip; Suvi M Virtanen
Serum alpha- and gamma-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus.
Diabetologia 2008;51(5):773-80.
2008: Iris Erlund; Raika Koli; Georg Alfthan; Jukka Marniemi; Pauli Puukka; Pirjo Mustonen; Pirjo Mattila; Antti Jula
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol.
The American journal of clinical nutrition 2008;87(2):323-31.
2007: Marja-Leena Silaste; Georg Alfthan; Antti Aro; Y Antero Kesäniemi; Sohvi Hörkkö
Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation.
The British journal of nutrition 2007;98(6):1251-8.
2007: Pirkko J Pussinen; Georg Alfthan; Pekka Jousilahti; Susanna Paju; Jaakko Tuomilehto
Systemic exposure to Porphyromonas gingivalis predicts incident stroke.
Atherosclerosis 2007;193(1):222-8.
2007: Jouko Sundvall; Jaana Leiviskä; Georg Alfthan; Erkki Vartiainen
Serum cholesterol during 27 years: assessment of systematic error and affecting factors and their role in interpreting population trends.
Clinica chimica acta; international journal of clinical chemistry 2007;378(1-2):93-8.
2007: Sari Voutilainen; Tomi-Pekka Tuomainen; Maarit Korhonen; Jaakko Mursu; Jyrki K Virtanen; Pertti Happonen; Georg Alfthan; Iris Erlund; Kari E North; MJ Mosher; Jussi Kauhanen; Jari Tiihonen; George A Kaplan; Jukka T Salonen
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.
PloS one 2007;2(1):e181.
2006: Anna Nurmi; Jaakko Mursu; Tarja Nurmi; Kristiina Nyyssönen; Georg Alfthan; Raimo Hiltunen; Jari Kaikkonen; Jukka T Salonen; Sari Voutilainen
Consumption of juice fortified with oregano extract markedly increases excretion of phenolic acids but lacks short- and long-term effects on lipid peroxidation in healthy nonsmoking men.
Journal of agricultural and food chemistry 2006;54(16):5790-6.
2006: Annamari Kilkkinen; Iris Erlund; Mikko J Virtanen; Georg Alfthan; Kari Ariniemi; Jarmo Virtamo
Serum enterolactone concentration and the risk of coronary heart disease in a case-cohort study of Finnish male smokers.
American journal of epidemiology 2006;163(8):687-93.
2006: Iris Erlund; Riitta Freese; Jukka Marniemi; Paula Hakala; Georg Alfthan
Bioavailability of quercetin from berries and the diet.
Nutrition and cancer 2006;54(1):13-7.
2006: Ursula S Schwab; A Riitta Törrönen; Esa Meririnne; Markku Saarinen; Georg Alfthan; Antti Aro; Matti Uusitupa
Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans.
The Journal of nutrition 2006;136(1):34-8.
2005: Liisa Uusitalo; Mikael Knip; Mike Kenward; Georg Alfthan; Jouko Sundvall; Antti Aro; Antti Reunanen; Hans K Akerblom; Suvi M Virtanen
Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.
Journal of pediatric endocrinology & metabolism : JPEM 2005;18(12):1409-16.
2005: Jyrki K Virtanen; Sari Voutilainen; Pertti Happonen; Georg Alfthan; Jari Kaikkonen; Jaakko Mursu; Tiina H Rissanen; George A Kaplan; Maarit Korhonen; Juhani Sivenius; Jukka T Salonen
Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2005;12(4):369-75.
2005: Pirkko J Pussinen; Kristiina Nyyssönen; Georg Alfthan; Riitta Salonen; Jari A Laukkanen; Jukka T Salonen
Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):833-8.
2005: Jyrki K Virtanen; Sari Voutilainen; Georg Alfthan; Maarit Korhonen; Tiina H Rissanen; Jaakko Mursu; George A Kaplan; Jukka T Salonen
Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.
Journal of internal medicine 2005;257(3):255-62.
2005: Jaakko Mursu; Sari Voutilainen; Tarja Nurmi; Georg Alfthan; Jyrki K Virtanen; Tiina H Rissanen; Pertti Happonen; Kristiina Nyyssönen; Jari Kaikkonen; Riitta Salonen; Jukka T Salonen
The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial.
Free radical biology & medicine 2005;38(4):527-34.
2004: Tommi Tolmunen; Jukka Hintikka; Sari Voutilainen; Anu Ruusunen; Georg Alfthan; Kristiina Nyyssönen; Heimo Viinamäki; George A Kaplan; Jukka T Salonen
Association between depressive symptoms and serum concentrations of homocysteine in men: a population study.
The American journal of clinical nutrition 2004;80(6):1574-8.
2004: Pirkko J Pussinen; Tiina Vilkuna-Rautiainen; Georg Alfthan; Timo Palosuo; Matti Jauhiainen; Jouko Sundvall; Marja Vesanen; Kari Mattila; Sirkka Asikainen
Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):2174-80.
2004: Pirkko J Pussinen; Georg Alfthan; Jaakko Tuomilehto; Sirkka Asikainen; Pekka Jousilahti
High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2004;11(5):408-11.
2004: Georg Alfthan; Kaisa Tapani; Katja Nissinen; Janna Saarela; Antti Aro
The effect of low doses of betaine on plasma homocysteine in healthy volunteers.
The British journal of nutrition 2004;92(4):665-9.
2004: Pirkko J Pussinen; Georg Alfthan; Harri Rissanen; Antti Reunanen; Sirkka Asikainen; Paul Knekt
Antibodies to periodontal pathogens and stroke risk.
Stroke; a journal of cerebral circulation 2004;35(9):2020-3.
2004: Sari Voutilainen; Jyrki K Virtanen; Tiina H Rissanen; Georg Alfthan; Jari A Laukkanen; Kristiina Nyyssönen; Jaakko Mursu; Veli-Pekka Valkonen; Tomi-Pekka Tuomainen; George A Kaplan; Jukka T Salonen
Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.
The American journal of clinical nutrition 2004;80(2):317-23.
2004: Peter Møller; Steffen Loft; Georg Alfthan; Riitta Freese
Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink.
Mutation research 2004;551(1-2):119-26.
2004: Georg Alfthan
Lowering risk factors for heart diseases by dietary approaches.
Ukrainskiĭ biokhimicheskiĭ zhurnal 2004;76(4):82-5.
2004: Marja-Leena Silaste; Maire Rantala; Georg Alfthan; Antti Aro; Joseph L Witztum; Y Antero Kesäniemi; Sohvi Hörkkö
Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a).
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):498-503.
2004: Pirkko J Pussinen; Matti Jauhiainen; Tiina Vilkuna-Rautiainen; Jouko Sundvall; Marja Vesanen; Kari Mattila; Timo Palosuo; Georg Alfthan; Sirkka Asikainen
Periodontitis decreases the antiatherogenic potency of high density lipoprotein.
Journal of lipid research 2004;45(1):139-47.
2003: Marjaana Lahti-Koski; Liisa M Valsta; Georg Alfthan; Heli Tapanainen; Antti Aro
Iron status of adults in the capital area of Finland.
European journal of nutrition 2003;42(5):287-92.
2003: Pirkko J Pussinen; Tiina Laatikainen; Georg Alfthan; Sirkka Asikainen; Pekka Jousilahti
Periodontitis is associated with a low concentration of vitamin C in plasma.
Clinical and diagnostic laboratory immunology 2003;10(5):897-902.
2003: Laura Lakio; Susanna Paju; Georg Alfthan; Terttu Tiirola; Sirkka Asikainen; Pirkko J Pussinen
Actinobacillus actinomycetemcomitans serotype d-specific antigen contains the O antigen of lipopolysaccharide.
Infection and immunity 2003;71(9):5005-11.
2003: Pirkko J Pussinen; Pekka Jousilahti; Georg Alfthan; Timo Palosuo; Sirkka Asikainen; Veikko Salomaa
Antibodies to periodontal pathogens are associated with coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1250-4.
2003: Katriina Ylönen; Georg Alfthan; Leif Groop; Carola Saloranta; Antti Aro; Suvi M Virtanen
Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study.
The American journal of clinical nutrition 2003;77(6):1434-41.
2003: Marja-Leena Silaste; Maire Rantala; Georg Alfthan; Antti Aro; Y Antero Kesäniemi
Plasma homocysteine concentration is decreased by dietary intervention.
The British journal of nutrition 2003;89(3):295-301.
2003: Georg Alfthan; M S Laurinen; Liisa M Valsta; T Pastinen; A Aro
Folate intake, plasma folate and homocysteine status in a random Finnish population.
European journal of clinical nutrition 2003;57(1):81-8.
2003: Iris Erlund; Jukka Marniemi; Paula Hakala; Georg Alfthan; Esa Meririnne; Antti Aro
Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.
European journal of clinical nutrition 2003;57(1):37-42.
2002: Ursula S Schwab; A Riitta Törrönen; Leena Toppinen; Georg Alfthan; Markku Saarinen; Antti Aro; Matti Uusitupa
Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects.
The American journal of clinical nutrition 2002;76(5):961-7.
2002: Riitta Freese; Georg Alfthan; Matti Jauhiainen; Samar Basu; Iris Erlund; Irma Salminen; Antti Aro; Marja Mutanen
High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects.
The American journal of clinical nutrition 2002;76(5):950-60.
2002: Maire Rantala; Marja-Leena Silaste; Anu Tuominen; Jari Kaikkonen; Jukka T Salonen; Georg Alfthan; Antti Aro; Y Antero Kesäniemi
Dietary modifications and gene polymorphisms alter serum paraoxonase activity in healthy women.
The Journal of nutrition 2002;132(10):3012-7.
2002: Iris Erlund; Marja-Leena Silaste; Georg Alfthan; M Rantala; Y Antero Kesäniemi; Antti Aro
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.
European journal of clinical nutrition 2002;56(9):891-8.
2002: Paivi Kleemola; Riitta Freese; Matti Jauhiainen; Raija Pahlman; Georg Alfthan; Marja Mutanen
Dietary determinants of serum paraoxonase activity in healthy humans.
Atherosclerosis 2002;160(2):425-32.
2002: Pirkko J Pussinen; Tiina Vilkuna-Rautiainen; Georg Alfthan; Kari Mattila; Sirkka Asikainen
Multiserotype enzyme-linked immunosorbent assay as a diagnostic aid for periodontitis in large-scale studies.
Journal of clinical microbiology 2002;40(2):512-8.
2001: Marja-Leena Silaste; Maire Rantala; M Sämpi; Georg Alfthan; Antti Aro; Y Antero Kesäniemi
Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women.
The Journal of nutrition 2001;131(10):2643-7.
2001: Iris Erlund; Georg Alfthan; Jukka Mäenpää; Antti Aro
Tea and coronary heart disease: the flavonoid quercetin is more bioavailable from rutin in women than in men.
Archives of internal medicine 2001;161(15):1919-20.
2001: Paul Knekt; Antti Reunanen; Georg Alfthan; Markku Heliövaara; Harri Rissanen; Jukka Marniemi; Arpo Aromaa
Hyperhomocystinemia: a risk factor or a consequence of coronary heart disease?
Archives of internal medicine 2001;161(13):1589-94.
2001: Paul Knekt; Georg Alfthan; Arpo Aromaa; M Heliövaara; Jukka Marniemi; Harri Rissanen; Antti Reunanen
Homocysteine and major coronary events: a prospective population study amongst women.
Journal of internal medicine 2001;249(5):461-5.
2001: Iris Erlund; Esa Meririnne; Georg Alfthan; Antti Aro
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.
The Journal of nutrition 2001;131(2):235-41.
2000: Iris Erlund; T Kosonen; Georg Alfthan; Jukka Mäenpää; Kristiina Perttunen; J Kenraali; J Parantainen; Antti Aro
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.
European journal of clinical pharmacology 2000;56(8):545-53.
2000: Erkki Vartiainen; Pekka Jousilahti; Georg Alfthan; Jouko Sundvall; P Pietinen; P Puska
Cardiovascular risk factor changes in Finland, 1972-1997.
International journal of epidemiology 2000;29(1):49-56.
1999: Sari Voutilainen; J D Morrow; L J Roberts; Georg Alfthan; H Alho; Kristiina Nyyssönen; Jukka T Salonen
Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1263-6.
1999: Iris Erlund; Georg Alfthan; H Siren; Kari Ariniemi; Antti Aro
Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;727(1-2):179-89.
1998: KE Liede; Georg Alfthan; Jarkko Hietanen; Jari Haukka; L M Saxen; OP Heinonen
Beta-carotene concentration in buccal mucosal cells with and without dysplastic oral leukoplakia after long-term beta-carotene supplementation in male smokers.
European journal of clinical nutrition 1998;52(12):872-6.
1998: Sari Voutilainen; Georg Alfthan; Kristiina Nyyssönen; Riitta Salonen; Jukka T Salonen
Association between elevated plasma total homocysteine and increased common carotid artery wall thickness.
Annals of medicine 1998;30(3):300-6.
1998: Päivi Kurttio; Juha Pekkanen; Georg Alfthan; Mikko Paunio; J J Jaakkola; O P Heinonen
Increased mercury exposure in inhabitants living in the vicinity of a hazardous waste incinerator: a 10-year follow-up.
Archives of environmental health 1998;53(2):129-37.
1996: M Anttolainen; L M Valsta; Georg Alfthan; P Kleemola; Irma Salminen; M Tamminen
Effect of extreme fish consumption on dietary and plasma antioxidant levels and fatty acid composition.
European journal of clinical nutrition 1996;50(11):741-6.
1995: Anu M Turpeinen; Georg Alfthan; L Valsta; E Hietanen; Jukka T Salonen; H Schunk; Kristiina Nyyssönen; Marja Mutanen
Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets.
Lipids 1995;30(6):485-92.
1995: Antti Aro; Georg Alfthan; P Varo
Effects of supplementation of fertilizers on human selenium status in Finland.
The Analyst 1995;120(3):841-3.
1994: Georg Alfthan; J Pekkanen; M Jauhiainen; Janne Pitkäniemi; M Karvonen; J Tuomilehto; Jukka T Salonen; C Ehnholm
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study.
Atherosclerosis 1994;106(1):9-19.
1991: Jukka T Salonen; Riitta Salonen; K Seppänen; S Rinta-Kiikka; M Kuukka; H Korpela; Georg Alfthan; M Kantola; W Schalch
Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status.
The American journal of clinical nutrition 1991;53(5):1222-9.
1988: P Varo; Georg Alfthan; P Ekholm; Antti Aro; P Koivistoinen
Selenium intake and serum selenium in Finland: effects of soil fertilization with selenium.
The American journal of clinical nutrition 1988;48(2):324-9.
1988: Jukka T Salonen; Riitta Salonen; K Seppänen; M Kantola; Markku Parviainen; Georg Alfthan; Pekka H Mäenpää; E Taskinen; Rainer Rauramaa
Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish men.
Atherosclerosis 1988;70(1-2):155-60.
1987: Aila Rissanen; Sirpa Sarlio-Lähteenkorva; Georg Alfthan; C G Gref; L Keso; M Salaspuro
Employed problem drinkers: a nutritional risk group?
The American journal of clinical nutrition 1987;45(2):456-61.
1983: Orville A Levander; Georg Alfthan; H Arvilommi; C G Gref; J K Huttunen; M Kataja; P Koivistoinen; J Pikkarainen
Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters.
The American journal of clinical nutrition 1983;37(6):887-97.