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Amanda Churchill

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Polymorphism, Single-Stranded Conformational

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Publications

TOP 3
Denize Atan; Jeff L Bidwell; Andrew D Dick; John V Forrester; Jarka Heissigerova; Aideen Hogan; Dara J Kilmartin; Lucia Kuffová; Amanda J Churchill
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis.
Denize Atan; Samantha Fraser-Bell; Jarka Heissigerova; Lucia Kuffová; Aideen Hogan; Adnan Tufail; Dara J Kilmartin; John V Forrester; Jeff L Bidwell; Andrew D Dick; Amanda J Churchill
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci.
J G Carter; J Cherry; K Williams; S Turner; David O Bates; Amanda J Churchill
Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease.

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All Publications

2013: Denize Atan; Jeff L Bidwell; Andrew D Dick; John V Forrester; Jarka Heissigerova; Aideen Hogan; Dara J Kilmartin; Lucia Kuffová; Amanda J Churchill
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis.
Molecular vision 2013;19():184-95.
2011: Denize Atan; Samantha Fraser-Bell; Jarka Heissigerova; Lucia Kuffová; Aideen Hogan; Adnan Tufail; Dara J Kilmartin; John V Forrester; Jeff L Bidwell; Andrew D Dick; Amanda J Churchill
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci.
Investigative ophthalmology & visual science 2011;52(6):3573-81.
2011: J G Carter; J Cherry; K Williams; S Turner; David O Bates; Amanda J Churchill
Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease.
Current eye research 2011;36(4):328-35.
2011: James G Carter; Amanda J Churchill
Analysis of SERPING1 and its association with age-related macular degeneration.
Acta ophthalmologica 2011;89(2):e212-3.
2010: James G Carter; Stephanie K West; Sally Painter; Richard J Haynes; Amanda J Churchill
β-Defensin 1 haplotype associated with postoperative endophthalmitis.
Acta ophthalmologica 2010;88(7):786-90.
2010: Denize Atan; Samantha Fraser-Bell; Jarka Heissigerova; Lucia Kuffova; Aideen Hogan; Adnan Tufail; Dara J Kilmartin; John V Forrester; Jeff Bidwell; Andrew D Dick; Amanda J Churchill
Cytokine polymorphism in noninfectious uveitis.
Investigative ophthalmology & visual science 2010;51(8):4133-42.
2010: Jing Hua; Christine Spee; Satoru Kase; Emma S Rennel; Anette L Magnussen; Yan Qiu; Alex Varey; Sandeep Dhayade; Amanda J Churchill; Steven J Harper; David O Bates; David R Hinton
Recombinant human VEGF165b inhibits experimental choroidal neovascularization.
Investigative ophthalmology & visual science 2010;51(8):4282-8.
2010: Anette L Magnussen; Emma S Rennel; Jing Hua; Heather S Bevan; Nicholas Beazley Long; Christina Lehrling; Melissa Gammons; Juergen Floege; Steven J Harper; Hansjürgen T Agostini; David O Bates; Amanda J Churchill
VEGF-A165b is cytoprotective and antiangiogenic in the retina.
Investigative ophthalmology & visual science 2010;51(8):4273-81.
2009: E S Rennel; Alex Varey; Amanda J Churchill; E R Wheatley; L Stewart; S Mather; David O Bates; Steven J Harper
VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo.
British journal of cancer 2009;101(7):1183-93.
2008: Dawid Nowak; Jeanette Woolard; Elianna Mohamed Amin; Olga Konopatskaya; Moin A Saleem; Amanda J Churchill; Michael R Ladomery; Steven J Harper; David O Bates
Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.
Journal of cell science 2008;121(Pt 20):3487-95.
2008: Amanda J Churchill; James G Carter; Conor Ramsden; Steven J Turner; Anna Yeung; Paul E C Brenchley; David W Ray
VEGF polymorphisms are associated with severity of diabetic retinopathy.
Investigative ophthalmology & visual science 2008;49(8):3611-6.
2007: James Carter; Amanda J Churchill; Chris Gorman; Richard Haynes
A case of bilateral endophthalmitis and carriage of beta-defensin 1 44CC genotype.
The British journal of ophthalmology 2007;91(9):1249-50.
2006: Amanda J Churchill; James G Carter; Helen C Lovell; Conor Ramsden; Steven J Turner; Anna Yeung; Julia Escardo; Denize Atan
VEGF polymorphisms are associated with neovascular age-related macular degeneration.
Human molecular genetics 2006;15(19):2955-61.
2006: O Konopatskaya; Amanda J Churchill; Steven J Harper; David O Bates; T A Gardiner
VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice.
Molecular vision 2006;12():626-32.
2005: Denize Atan; Steve J Turner; Dara J Kilmartin; John V Forrester; Jeff Bidwell; Andrew D Dick; Amanda J Churchill
Cytokine gene polymorphism in sympathetic ophthalmia.
Investigative ophthalmology & visual science 2005;46(11):4245-50.
2005: R M Perrin; O Konopatskaya; Y Qiu; S Harper; David O Bates; Amanda J Churchill
Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor.
Diabetologia 2005;48(11):2422-7.
2005: Amanda J Churchill; Anna Yeung
A compound heterozygous change found in Peters' anomaly.
Molecular vision 2005;11():66-70.
2003: Samantha L Free; Tejal N Mitchell; Kathleen A Williamson; Amanda J Churchill; Simon D Shorvon; Anthony T Moore; Veronica van Heyningen; Sanjay M Sisodiya
Quantitative MR image analysis in subjects with defects in the PAX6 gene.
NeuroImage 2003;20(4):2281-90.
2003: Brenda L Powell; Carmel Toomes; Shiela Scott; Anna Yeung; Nicola J Marchbank; Paul G D Spry; Rosemary Lumb; Chris F Inglehearn; Amanda J Churchill
Polymorphisms in OPA1 are associated with normal tension glaucoma.
Molecular vision 2003;9():460-4.
2003: Tejal N Mitchell; Samantha L Free; Kathleen A Williamson; John M Stevens; Amanda J Churchill; Isabel M Hanson; Simon D Shorvon; Anthony T Moore; Veronica van Heyningen; Sanjay M Sisodiya
Polymicrogyria and absence of pineal gland due to PAX6 mutation.
Annals of neurology 2003;53(5):658-63.
2002: N Patel; Amanda J Churchill; Carmel Toomes; Nicola J Marchbank; Chris F Inglehearn; N Foulds; A Moosavi; M Teimory
Importance of molecular testing in dominant optic atrophy.
The British journal of ophthalmology 2002;86(11):1314-5.
2002: Nicola J Marchbank; Jamie E Craig; Jack P Leek; Michael G Toohey; Amanda J Churchill; Alexander F Markham; David A Mackey; Carmel Toomes; Chris F Inglehearn
Deletion of the OPA1 gene in a dominant optic atrophy family: evidence that haploinsufficiency is the cause of disease.
Journal of medical genetics 2002;39(8):e47.
2001: Carmel Toomes; Nicola J Marchbank; David A Mackey; Jamie E Craig; R A Newbury-Ecob; C P Bennett; C J Vize; S P Desai; Graeme C M Black; N Patel; M Teimory; Alexander F Markham; Chris F Inglehearn; Amanda J Churchill
Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy.
Human molecular genetics 2001;10(13):1369-78.
2001: N J Murton; L French; Carmel Toomes; S S Joseph; I Rehman; B L Hopkins; Chris F Inglehearn; Amanda J Churchill
A high-density transcript map of the human dominant optic atrophy OPA1 gene locus and re-evaluation of evidence for a founder haplotype.
Cytogenetics and cell genetics 2001;92(1-2):97-102.
2000: Rahat Perveen; Christopher Lloyd; Jill Clayton-Smith; Amanda J Churchill; Veronica van Heyningen; Isabel M Hanson; D Taylor; Carole M E McKeown; Maurice Super; Bronwyn Kerr; R Winter; Graeme C M Black
Phenotypic variability and asymmetry of Rieger syndrome associated with PITX2 mutations.
Investigative ophthalmology & visual science 2000;41(9):2456-60.
2000: Adam P Booth; Rashida Anwar; H Chen; Amanda J Churchill; J Jay; J Polansky; T Nguyen; Alexander F Markham
Genetic screening in a large family with juvenile onset primary open angle glaucoma.
The British journal of ophthalmology 2000;84(7):722-6.
2000: N J Murton; I Rehman; Graeme C M Black; Chris F Inglehearn; Amanda J Churchill
A novel deletion (IVS11+3del4) identified in the human PAX6 gene in a patient with aniridia.
Human mutation 2000;15(6):582.
2000: Amanda J Churchill; Isabel M Hanson; Alexander F Markham
Prenatal diagnosis of aniridia.
Ophthalmology 2000;107(6):1153-6.
2000: Amanda J Churchill; C J Vize; OG Stewart; O Backhouse
What factors influence cataract waiting list time?
The British journal of ophthalmology 2000;84(4):429-31.
1999: Isabel M Hanson; Amanda J Churchill; J Love; RA Axton; T Moore; M Clarke; F Meire; Veronica van Heyningen
Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations.
Human molecular genetics 1999;8(2):165-72.
1998: Amanda J Churchill; W A Franks; D V Ash
An alternative and more cost effective method of delivery of radiotherapy in age related macular degeneration.
The British journal of ophthalmology 1998;82(4):373-5.
1998: Amanda J Churchill; Adam P Booth; Rashida Anwar; Alexander F Markham
PAX 6 is normal in most cases of Peters' anomaly.
Eye (London, England) 1998;12 ( Pt 2)():299-303.
1998: J Love; RA Axton; Amanda J Churchill; Veronica van Heyningen; Isabel M Hanson
A new set of primers for mutation analysis of the human PAX6 gene.
Human mutation 1998;12(2):128-34.
1997: A Booth; Amanda J Churchill; Rashida Anwar; M Menage; A Markham
The genetics of primary open angle glaucoma.
The British journal of ophthalmology 1997;81(5):409-14.