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Leo Chylack

Research Profile

Disorders

Cataract

Anatomy

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Leo T Chylack; Lori J Chappell; Alan H Feiveson; Dale S Hardy; Lisa J Marak; Leif Peterson; William H Tung; Mary L Wear; Francis A Cucinotta
NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity.
Leo T Chylack; Leif Peterson; Alan H Feiveson; Mary L Wear; F Keith Manuel; William H Tung; Dale S Hardy; Lisa J Marak; Francis A Cucinotta
NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.
Shuhua Song; Mark J Hanson; Bing-Fen Liu; Leo T Chylack; Jack J-N Liang
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching.

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2012: Leo T Chylack; Lori J Chappell; Alan H Feiveson; Dale S Hardy; Lisa J Marak; Leif Peterson; William H Tung; Mary L Wear; Francis A Cucinotta
NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity.
Radiation research 2012;178(1):25-32.
2009: Leo T Chylack; Leif Peterson; Alan H Feiveson; Mary L Wear; F Keith Manuel; William H Tung; Dale S Hardy; Lisa J Marak; Francis A Cucinotta
NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.
Radiation research 2009;172(1):10-20.
2008: Shuhua Song; Mark J Hanson; Bing-Fen Liu; Leo T Chylack; Jack J-N Liang
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching.
Molecular vision 2008;14():1282-7.
2007: Martha Savaria Morris; Paul F Jacques; Leo T Chylack; Susan E Hankinson; Walter C Willett; Larry D Hubbard; Allen Taylor
Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions.
Ophthalmic epidemiology 2007;14(5):288-98.
2007: Minyi Lu; Allen Taylor; Leo T Chylack; Gail Rogers; Susan E Hankinson; Walter C Willett; Paul F Jacques
Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density.
Journal of the American College of Nutrition 2007;26(2):133-40.
2006: David C Herman; Mae O Gordon; Julia A Beiser; Leo T Chylack; Kathleen A Lamping; Oliver D Schein; Joern B Soltau; Michael A Kass
Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study.
American journal of ophthalmology 2006;142(5):800-10.
2006: Chung-Jung Chiu; Larry D Hubbard; Jane Armstrong; Gail Rogers; Paul F Jacques; Leo T Chylack; Susan E Hankinson; Walter C Willett; Allen Taylor
Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration.
The American journal of clinical nutrition 2006;83(4):880-6.
2006: Dhirendra P Singh; Eri Kubo; Yoshihiro Takamura; Toshimichi Shinohara; A Kumar; Leo T Chylack; Nigar Fatma
DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF.
Journal of molecular biology 2006;355(3):379-94.
2005: Chung-Jung Chiu; Martha Savaria Morris; Gail Rogers; Paul F Jacques; Leo T Chylack; William Tung; Susan E Hankinson; Walter C Willett; Allen Taylor
Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities.
The American journal of clinical nutrition 2005;81(6):1411-6.
2005: Paul F Jacques; Allen Taylor; Suzen M Moeller; Susan E Hankinson; Gail Rogers; William Tung; José Ludovico; Walter C Willett; Leo T Chylack
Long-term nutrient intake and 5-year change in nuclear lens opacities.
Archives of ophthalmology 2005;123(4):517-26.
2005: Minyi Lu; Allen Taylor; Leo T Chylack; Gail Rogers; Susan E Hankinson; Walter C Willett; Paul F Jacques
Dietary fat intake and early age-related lens opacities.
The American journal of clinical nutrition 2005;81(4):773-9.
2004: Leo T Chylack; Ling Fu; Ronald Mancini; Matthew D Martin-Rehrmann; Aleister J Saunders; Genevieve Konopka; Di Tian; E Tessa Hedley-Whyte; Rebecca D Folkerth; Lee E Goldstein
Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.
Experimental eye research 2004;79(6):941-8.
2004: Nigar Fatma; Eri Kubo; Leo T Chylack; Toshimichi Shinohara; Yoshio Akagi; Dhirendra P Singh
LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.
American journal of physiology. Cell physiology 2004;287(2):C508-16.
2004: Suzen M Moeller; Allen Taylor; Katherine L Tucker; Marjorie L McCullough; Leo T Chylack; Susan E Hankinson; Walter C Willett; Paul F Jacques
Overall adherence to the dietary guidelines for americans is associated with reduced prevalence of early age-related nuclear lens opacities in women.
The Journal of nutrition 2004;134(7):1812-9.
2004: Martha Savaria Morris; Paul F Jacques; Susan E Hankinson; Leo T Chylack; Walter C Willett; Allen Taylor
Moderate alcoholic beverage intake and early nuclear and cortical lens opacities.
Ophthalmic epidemiology 2004;11(1):53-65.
2003: Paul F Jacques; Suzen M Moeller; Susan E Hankinson; Leo T Chylack; Gail Rogers; William Tung; John K Wolfe; Walter C Willett; Allen Taylor
Weight status, abdominal adiposity, diabetes, and early age-related lens opacities.
The American journal of clinical nutrition 2003;78(3):400-5.
2003: preeti sharma; Nigar Fatma; Eri Kubo; Toshimichi Shinohara; Leo T Chylack; Dhirendra P Singh
Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells.
The Journal of biological chemistry 2003;278(22):20037-46.
2003: Lee E Goldstein; Julien A Muffat; Robert A Cherny; Robert D. Moir; Maria H Ericsson; Xudong Huang; Christine Mavros; Jennifer A Coccia; Kyle Y Faget; Karlotta A Fitch; Colin L Masters; Rudolph E Tanzi; Leo T Chylack; Ashley I Bush
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet 2003;361(9365):1258-65.
2003: Eri Kubo; Dhirendra P Singh; Nigar Fatma; Toshimichi Shinohara; Peggy Zelenka; Venkat N Reddy; Leo T Chylack
Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells.
Histochemistry and cell biology 2003;119(4):289-99.
2003: Wolfgang Schalch; Leo T Chylack
[Antioxidant micronutrients and cataract. Review and comparison of the AREDS and REACT cataract studies].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 2003;100(3):181-9.
2003: James A Davison; Leo T Chylack
Clinical application of the lens opacities classification system III in the performance of phacoemulsification.
Journal of cataract and refractive surgery 2003;29(1):138-45.
2002: Eri Kubo; Nigar Fatma; preeti sharma; Toshimichi Shinohara; Leo T Chylack; Y Akagi; Dhirendra P Singh
Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF).
Journal of molecular biology 2002;320(5):1053-63.
2002: June Weintraub; Allen Taylor; Paul Jacques; Walter C Willett; Bernard Rosner; GRaham Colditz; Leo T Chylack; Susan E Hankinson
Postmenopausal hormone use and lens opacities.
Ophthalmic epidemiology 2002;9(3):179-90.
2002: Allen Taylor; Paul F Jacques; Leo T Chylack; Susan E Hankinson; Patricia M Khu; Gail Rogers; Judith Friend; William Tung; John K Wolfe; Nita Padhye; Walter C Willett
Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities.
The American journal of clinical nutrition 2002;75(3):540-9.
2002: Leo T Chylack; Nicholas P Brown; Anthony Bron; Mark Hurst; Wolfgang Köpcke; Uta Thien; Wolfgang Schalch
The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract.
Ophthalmic epidemiology 2002;9(1):49-80.
2001: Nigar Fatma; Dhirendra P Singh; Toshimichi Shinohara; Leo T Chylack
Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress.
The Journal of biological chemistry 2001;276(52):48899-907.
2001: Paul F Jacques; Leo T Chylack; Susan E Hankinson; P M Khu; Gail Rogers; Judith Friend; William Tung; John K Wolfe; N Padhye; Walter C Willett; Allen Taylor
Long-term nutrient intake and early age-related nuclear lens opacities.
Archives of ophthalmology 2001;119(7):1009-19.
2001: Dhirendra P Singh; Nigar Fatma; A Kimura; Leo T Chylack; Toshimichi Shinohara
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes.
Biochemical and biophysical research communications 2001;283(4):943-55.
2001: S Machida; P Chaudhry; T Shinohara; Dhirendra P Singh; Venkat N Reddy; Leo T Chylack; Paul Sieving; Ronald A Bush
Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats.
Investigative ophthalmology & visual science 2001;42(5):1087-95.
2000: preeti sharma; Dhirendra P Singh; Nigar Fatma; Leo T Chylack; Toshimichi Shinohara
Activation of LEDGF gene by thermal-and oxidative-stresses.
Biochemical and biophysical research communications 2000;276(3):1320-4.
2000: Nigar Fatma; Dhirendra P Singh; Toshimichi Shinohara; Leo T Chylack
Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus.
Investigative ophthalmology & visual science 2000;41(9):2648-57.
2000: Lee E Goldstein; M C Leopold; Xudong Huang; Craig S Atwood; Aleister J Saunders; Mariana A Hartshorn; JT Lim; K Y Faget; J A Muffat; RC Scarpa; Leo T Chylack; E F Bowden; Rudolph E Tanzi; Ashley I Bush
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Biochemistry 2000;39(24):7266-75.
2000: Toshimichi Shinohara; Dhirendra P Singh; Leo T Chylack
Review: Age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF).
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2000;16(2):181-91.
2000: M Nakamura; Dhirendra P Singh; Eri Kubo; Leo T Chylack; Toshimichi Shinohara
LEDGF: survival of embryonic chick retinal photoreceptor cells.
Investigative ophthalmology & visual science 2000;41(5):1168-75.
2000: M Balaram; W H Tung; J R Kuszak; Masahiko Ayaki; Toshimichi Shinohara; Leo T Chylack
Noncontact specular microscopy of human lens epithelium.
Investigative ophthalmology & visual science 2000;41(2):474-81.
2000: Dhirendra P Singh; N Ohguro; T Kikuchi; T Sueno; Venkat N Reddy; K Yuge; Leo T Chylack; Toshimichi Shinohara
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts.
Biochemical and biophysical research communications 2000;267(1):373-81.
1999: Masahiko Ayaki; T Sueno; Dhirendra P Singh; Leo T Chylack; Toshimichi Shinohara
Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture.
Experimental eye research 1999;69(1):139-42.
1999: Dhirendra P Singh; N Ohguro; Leo T Chylack; Toshimichi Shinohara
Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses.
Investigative ophthalmology & visual science 1999;40(7):1444-51.
1999: Marjorie F Lou; J E Dickerson; William Tung; John K Wolfe; Leo T Chylack
Correlation of nuclear color and opalescence with protein S-thiolation in human lenses.
Experimental eye research 1999;68(5):547-52.
1999: Dhirendra P Singh; T Sueno; T Kikuchi; S C Guru; S Yu; J Horwitz; Leo T Chylack; Toshimichi Shinohara
Antibodies to a microbial peptide sharing sequence homology with betaA3-crystallin damage lens epithelial cells in vitro and in vivo.
Autoimmunity 1999;29(4):311-22.
1998: BK Das; TX Sun; NJ Akhtar; Leo T Chylack; Jack J-N Liang
Fluorescence and immunochemical studies of advanced glycation-related lens pigments.
Investigative ophthalmology & visual science 1998;39(11):2058-66.
1998: M Cristina Leske; Leo T Chylack; Q He; Suh-Yuh Wu; Elinor Randi Schoenfeld; Judith Friend; J Wolfe
Antioxidant vitamins and nuclear opacities: the longitudinal study of cataract.
Ophthalmology 1998;105(5):831-6.
1998: M Cristina Leske; Leo T Chylack; Q He; Suh-Yuh Wu; Elinor Randi Schoenfeld; J Friend; J Wolfe
Risk factors for nuclear opalescence in a longitudinal study. LSC Group. Longitudinal Study of Cataract.
American journal of epidemiology 1998;147(1):36-41.
1997: M Cristina Leske; Leo T Chylack; Q He; Suh-Yuh Wu; Elinor Randi Schoenfeld; Judith Friend; J Wolfe
Incidence and progression of cortical and posterior subcapsular opacities: the Longitudinal Study of Cataract. The LSC Group.
Ophthalmology 1997;104(12):1987-93.
1997: Masahiko Ayaki; William Tung; John K Wolfe; Toshimichi Shinohara; Nobuhiro Ibaraki; Hideaki Oharazawa; K Ohara; Leo T Chylack
New non-contact specular microscope for lens epithelial cell visualization.
Experimental eye research 1997;65(1):143-6.
1997: T Sueno; E Inoue; Dhirendra P Singh; T Awata; Leo T Chylack; Toshimichi Shinohara
Oral administration of lens homogenate suppresses antibody production in mice injected with beta-crystallin emulsified in CFA.
Experimental eye research 1997;64(3):379-85.
1997: Nobuhiro Ibaraki; Li-Ren Lin; Loan Dang; Venkat N Reddy; Dhirendra P Singh; T Sueno; Leo T Chylack; Toshimichi Shinohara
Anti-beta-crystallin antibodies (mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture.
Experimental eye research 1997;64(2):229-38.
1996: M Cristina Leske; Leo T Chylack; Suh-Yuh Wu; Elinor Randi Schoenfeld; Q He; Judith Friend; J Wolfe
Incidence and progression of nuclear opacities in the Longitudinal Study of Cataract.
Ophthalmology 1996;103(5):705-12.
1995: Leo T Chylack; John K Wolfe; Judith Friend; W Tung; D M Singer; N P Brown; M A Hurst; W Köpcke; W Schalch
Validation of methods for the assessment of cataract progression in the Roche European-American Anticataract Trial (REACT)
Ophthalmic epidemiology 1995;2(2):59-75.
1993: M Karbassi; P C Magnante; John K Wolfe; Leo T Chylack
Objective line spread function measurements, Snellen acuity, and LOCS II classification in patients with cataract.
Optometry and vision science : official publication of the American Academy of Optometry 1993;70(11):956-62.
1993: Leo T Chylack; G Mantell; John K Wolfe; Judith Friend; B Rosner
Lovastatin and the human lens; results of a two year study. The MSDRL Study Group.
Optometry and vision science : official publication of the American Academy of Optometry 1993;70(11):937-43.
1993: M Karbassi; P M Khu; D M Singer; Leo T Chylack
Evaluation of lens opacities classification system III applied at the slitlamp.
Optometry and vision science : official publication of the American Academy of Optometry 1993;70(11):923-8.
1993: Leo T Chylack; John K Wolfe; Judith Friend; P M Khu; D M Singer; D McCarthy; J del Carmen; B Rosner
Quantitating cataract and nuclear brunescence, the Harvard and LOCS systems.
Optometry and vision science : official publication of the American Academy of Optometry 1993;70(11):886-95.
1993: Leo T Chylack; John K Wolfe; D M Singer; M Cristina Leske; Mark A Bullimore; I L Bailey; Judith Friend; D McCarthy; Suh-Yuh Wu
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Archives of ophthalmology 1993;111(6):831-6.
1993: Leo T Chylack; G Jakubicz; B Rosner; P Khu; J Libman; John K Wolfe; N Padhye; Judith Friend
Contrast sensitivity and visual acuity in patients with early cataracts.
Journal of cataract and refractive surgery 1993;19(3):399-404.
1993: Leo T Chylack; N Padhye; P M Khu; C Wehner; J Wolfe; D McCarthy; B Rosner; Judith Friend
Loss of contrast sensitivity in diabetic patients with LOCS II classified cataracts.
The British journal of ophthalmology 1993;77(1):7-11.
1992: J H Seland; Leo T Chylack; John K Wolfe
Indirect spectral transmission ratio measurements of the aging crystalline lens nucleus.
Acta ophthalmologica 1992;70(3):376-82.
1990: Leo T Chylack; J Friend
Intermediary metabolism of the lens: a historical perspective 1928-1989.
Experimental eye research 1990;50(6):575-82.
1990: John K Wolfe; Leo T Chylack
Objective measurement of cortical and subcapsular opacification in retroillumination photographs.
Ophthalmic research 1990;22 Suppl 1():62-7.
1989: Leo T Chylack; M Cristina Leske; D McCarthy; P Khu; T Kashiwagi; Robert D Sperduto
Lens opacities classification system II (LOCS II)
Archives of ophthalmology 1989;107(7):991-7.
1989: W K Clair; Leo T Chylack; E F Cook; L Goldman
Allopurinol use and the risk of cataract formation.
The British journal of ophthalmology 1989;73(3):173-6.
1989: Leo T Chylack; M Cristina Leske; P Khu; D McCarthy; Suh-Yuh Wu
Strategies for measuring the rate of age-related cataract formation in vivo.
Lens and eye toxicity research 1989;6(4):515-22.
1989: C V Harding; Nalin J Unakar; Mihir Bagchi; Leo T Chylack; Robert S Jampel; W F Bobrowski; Loan Dang; J Y Tsui; D Harding
Elemental and structural studies of the rat galactose cataract.
Lens and eye toxicity research 1989;6(3):477-501.
1988: Hong-ming Cheng; R Gilberto González; I von Saltza; Leo T Chylack; N J Hutson
Glucose flux and the redox state of pyridine dinucleotides in the rat lens.
Experimental eye research 1988;46(6):947-52.
1988: Leo T Chylack; B Rosner; O White; W H Tung; L D Sher
Standardization and analysis of digitized photographic data in the longitudinal documentation of cataractous growth.
Current eye research 1988;7(3):223-35.
1988: Leo T Chylack; M Cristina Leske; Robert D Sperduto; P Khu; D McCarthy
Lens Opacities Classification System.
Archives of ophthalmology 1988;106(3):330-4.
1988: M Cristina Leske; Leo T Chylack; Robert D Sperduto; P Khu; Suh-Yuh Wu; D McCarthy
Evaluation of a Lens Opacities Classification System.
Archives of ophthalmology 1988;106(3):327-9.
1987: George B. Benedek; Leo T Chylack; T Libondi; P Magnante; M Pennett
Quantitative detection of the molecular changes associated with early cataractogenesis in the living human lens using quasielastic light scattering.
Current eye research 1987;6(12):1421-32.
1987: Leo T Chylack; B Rosner; Hong-ming Cheng; D McCarthy; M Pennett
Sources of variance in the objective documentation of human cataractous change with Topcon SL-45 and Neitz-CTR retroillumination photography and computerized image analysis.
Current eye research 1987;6(12):1381-90.
1986: John K Wolfe; Leo T Chylack
Glucose metabolism by human cataracts in culture.
Experimental eye research 1986;43(2):243-9.
1986: T Libondi; P Magnante; Leo T Chylack; George B. Benedek
In vivo measurement of the aging rabbit lens using quasielastic light scattering.
Current eye research 1986;5(6):411-9.
1985: John K Wolfe; M K Gillis; Leo T Chylack
Glucose metabolism in the calf lens.
Experimental eye research 1985;40(4):629-41.
1985: Hong-ming Cheng; R G González; P A Barnett; J B Aguayo; J Wolfe; Leo T Chylack
Sorbitol/fructose metabolism in the lens.
Experimental eye research 1985;40(2):223-9.
1984: R Gilberto González; P Barnett; Hong-ming Cheng; Leo T Chylack
Altered phosphate metabolism in the intact rabbit lens under high glucose conditions and its prevention by an aldose reductase inhibitor.
Experimental eye research 1984;39(5):553-62.
1984: R Gilberto González; P Barnett; J Aguayo; Hong-ming Cheng; Leo T Chylack
Direct measurement of polyol pathway activity in the ocular lens.
Diabetes 1984;33(2):196-9.
1983: C V Harding; Leo T Chylack; S R Susan; Woo-Kuen Lo; W F Bobrowski
Calcium-containing opacities in the human lens.
Investigative ophthalmology & visual science 1983;24(9):1194-202.
1982: C V Harding; Leo T Chylack; S R Susan; Woo-Kuen Lo; W F Bobrowski
Elemental and ultrastructural analysis of specific human lens opacities.
Investigative ophthalmology & visual science 1982;23(1):1-13.
1982: R Gilberto González; J Willis; J Aguayo; P Campbell; Leo T Chylack; T Schleich
13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens.
Investigative ophthalmology & visual science 1982;22(6):808-11.
1982: John K Wolfe; B D Peczon; Leo T Chylack
Kinetics of calf lens phosphofructokinase activity at physiological substrate concentrations.
Experimental eye research 1982;34(6):945-52.
1981: Hong-ming Cheng; Leo T Chylack; I von Saltza
Supplementing glucose metabolism in human senile cataracts.
Investigative ophthalmology & visual science 1981;21(6):812-8.
1981: John K Wolfe; B D Peczon; Leo T Chylack
Calf lens phosphofructokinase: purification by single-step affinity chromatography and partial characterization.
Experimental eye research 1981;32(5):553-62.