Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
NetworkView
Tomas Cihlar
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles
free of charge to researchers worldwide.
Research Profile (preview)
Chemicals & Drugs
Physiology
Anatomy
Genes & Molecular Sequences
Living Beings
Sign-in to see full Profile
Network (preview)
8
Boojamra, Constantine
8
Mackman, Richard
8
Ray, Adrian
7
Swaminathan, Swami
7
Fuller, Michael
6
Birkus, Gabriel
6
Mulato, Andrew
6
Vela, Jennifer
5
Kim, Choung
5
Ho, Edmund
4
Hui, Hon
4
Laflamme, Genevieve
4
Lin, DC
4
Cherrington, Julie
3
Douglas, Janet
Sign-in to see all Coauthors
Publications
Sign-in to see all Publications
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
Geonetwork of Tomas Cihlar (preview)
Cities where this author has publications
Cities where co-authors of this author have publications
Sign-in to see more
All Publications
-
2009: Boojamra Constantine G; Parrish Jay P; Sperandio David; Gao Ying; Petrakovsky Oleg V; Lee Sharon K; Markevitch David Y; Vela Jennifer E; Laflamme Genevieve; Chen James M; Ray Adrian S; Barron Abraham C; Sparacino Mark L; Desai Manoj C; Kim Choung U; Cihlar Tomas; Mackman Richard L
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2009;17(4):1739-46.
-
2008: Greene Warner C; Debyser Zeger; Ikeda Yasuhiro; Freed Eric O; Stephens Edward; Yonemoto Wes; Buckheit Robert W; Esté José A; Cihlar Tomas
Novel targets for HIV therapy.
Antiviral research 2008;80(3):251-65.
-
2008: Van Rompay Koen K A; Durand-Gasselin Lucie; Brignolo Laurie L; Ray Adrian S; Abel Kristina; Cihlar Tomas; Spinner Abigail; Jerome Christopher; Moore Joseph; Kearney Brian P; Marthas Marta L; Reiser Hans; Bischofberger Norbert
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
Antimicrobial agents and chemotherapy 2008;52(9):3144-60.
-
2008: Birkus Gabriel; Kutty Nilima; He Gong-Xin; Mulato Andrew; Lee William; McDermott Martin; Cihlar Tomas
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
Molecular pharmacology 2008;74(1):92-100.
-
2008: Reiser Hans; Wang Jianying; Chong Lee; Watkins William J; Ray Adrian S; Shibata Riri; Birkus Gabriel; Cihlar Tomas; Wu Sylvia; Li Bei; Liu Xiaohong; Henne Ilana N; Wolfgang Grushenka H I; Desai Manoj; Rhodes Gerald R; Fridland Arnold; Lee William A; Plunkett William; Vail David; Thamm Douglas H; Jeraj Robert; Tumas Daniel B
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2824-32.
-
2008: Boojamra Constantine G; Mackman Richard L; Markevitch David Y; Prasad Vidya; Ray Adrian S; Douglas Janet; Grant Deborah; Kim Choung U; Cihlar Tomas
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
Bioorganic & medicinal chemistry letters 2008;18(3):1120-3.
-
2008: Mackman Richard L; Lin Kuei-Ying; Boojamra Constantine G; Hui Hon; Douglas Janet; Grant Deborah; Petrakovsky Oleg; Prasad Vidya; Ray Adrian S; Cihlar Tomas
Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
Bioorganic & medicinal chemistry letters 2008;18(3):1116-9.
-
2008: Cihlar Tomas; Ray Adrian S; Boojamra Constantine G; Zhang Lijun; Hui Hon; Laflamme Genevieve; Vela Jennifer E; Grant Deborah; Chen James; Myrick Florence; White Kirsten L; Gao Ying; Lin Kuei-Ying; Douglas Janet L; Parkin Neil T; Carey Anne; Pakdaman Rowchanak; Mackman Richard L
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Antimicrobial agents and chemotherapy 2008;52(2):655-65.
-
2008: Ray Adrian S; Vela Jennifer E; Boojamra Constantine G; Zhang Lijun; Hui Hon; Callebaut Christian; Stray Kirsten; Lin Kuei-Ying; Gao Ying; Mackman Richard L; Cihlar Tomas
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Antimicrobial agents and chemotherapy 2008;52(2):648-54.
-
2007: Mackman Richard L; Boojamra Constantine G; Prasad Vidya; Zhang Lijun; Lin Kuei-Ying; Petrakovsky Oleg; Babusis Darius; Chen James; Douglas Janet; Grant Deborah; Hui Hon C; Kim Choung U; Markevitch David Y; Vela Jennifer; Ray Adrian; Cihlar Tomas
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
Bioorganic & medicinal chemistry letters 2007;17(24):6785-9.
-
2007: Mackman Richard L; Zhang Lijun; Prasad Vidya; Boojamra Constantine G; Douglas Janet; Grant Deborah; Hui Hon; Kim Choung U; Laflamme Genevieve; Parrish Jay; Stoycheva Antitsa D; Swaminathan Swami; Wang Keyu; Cihlar Tomas
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
Bioorganic & medicinal chemistry 2007;15(16):5519-28.
-
2007: Ray Adrian S; Cihlar Tomas
Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.
The Journal of infectious diseases 2007;195(9):1389-90; author reply 1390-1.
-
2007: Birkus Gabriel; Wang Ruth; Liu Xiaohong; Kutty Nilima; MacArthur Holly; Cihlar Tomas; Gibbs Craig; Swaminathan Swami; Lee William; McDermott Martin
Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Antimicrobial agents and chemotherapy 2007;51(2):543-50.
-
2007: Mackman Richard L; Zhang Lijun; Prasad Vidya; Boojamra Constantine G; Chen James; Douglas Janet; Grant Deborah; Laflamme Genevieve; Hui Hon; Kim Choung U; Parrish Jay; Stoycheva Antitsa D; Swaminathan Swami; Wang KeYu; Cihlar Tomas
Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: a comparison of phosphonates and corresponding nucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):573-7.
-
2007: Cihlar Tomas; Ray Adrian S; Laflamme Genevieve; Vela Jennifer E; Tong Leah; Fuller Michael D; Roy Anupma; Rhodes Gerald R
Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors.
Antiviral therapy 2007;12(2):267-72.
-
2006: Vidal Francesc; Domingo Joan Carles; Guallar Jordi; Saumoy Maria; Cordobilla Begoña; Sánchez de la Rosa Rainel; Giralt Marta; Alvarez Maria Luisa; López-Dupla Miguel; Torres Ferran; Villarroya Francesc; Cihlar Tomas; Domingo Pere
In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.
Antimicrobial agents and chemotherapy 2006;50(11):3824-32.
-
2006: Ray Adrian S; Cihlar Tomas; Robinson Kelly L; Tong Leah; Vela Jennifer E; Fuller Michael D; Wieman Lani M; Eisenberg Eugene J; Rhodes Gerry R
Mechanism of active renal tubular efflux of tenofovir.
Antimicrobial agents and chemotherapy 2006;50(10):3297-304.
-
2006: Cihlar Tomas; He Gong-Xin; Liu Xiaohong; Chen James M; Hatada Marcos; Swaminathan Swami; McDermott Martin J; Yang Zheng-Yu; Mulato Andrew S; Chen Xiaowu; Leavitt Stephanie A; Stray Kirsten M; Lee William A
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
Journal of molecular biology 2006;363(3):635-47.
-
2006: Cihlar Tomas
Nucleotide HIV reverse transcriptase inhibitors: tenofovir and beyond.
Current opinion in HIV and AIDS 2006;1(5):373-9.
-
2005: Douglas Janet L; Panis Marites L; Ho Edmund; Lin Kuei-Ying; Krawczyk Steve H; Grant Deborah M; Cai Ruby; Swaminathan Swami; Chen Xiaowu; Cihlar Tomas
Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms.
Antimicrobial agents and chemotherapy 2005;49(6):2460-6.
-
2005: Lee William A; He Gong-Xin; Eisenberg Eugene; Cihlar Tomas; Swaminathan Swami; Mulato Andrew; Cundy Kenneth C
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Antimicrobial agents and chemotherapy 2005;49(5):1898-906.
-
2004: Rengelshausen Jens; Lindenmaier Heike; Cihlar Tomas; Walter-Sack Ingeborg; Haefeli Walter Emil; Weiss Johanna
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
Biochemical and biophysical research communications 2004;320(1):90-4.
-
2003: Douglas Janet L; Panis Marites L; Ho Edmund; Lin Kuei-Ying; Krawczyk Steve H; Grant Deborah M; Cai Ruby; Swaminathan Swami; Cihlar Tomas
Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein.
Journal of virology 2003;77(9):5054-64.
-
2003: Birkus G; Gibbs C S; Cihlar T
Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.
Journal of viral hepatitis 2003;10(1):50-4.
-
2002: Cihlar Tomas; Birkus Gabriel; Greenwalt Dale E; Hitchcock Michael J M
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.
Antiviral research 2002;54(1):37-45.
-
2002: Birkus Gabriel; Hitchcock Michael J M; Cihlar Tomas
Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy 2002;46(3):716-23.
-
2002: Hill George; Cihlar Tomas; Oo Charles; Ho Edmund S; Prior Ken; Wiltshire Hugh; Barrett Jo; Liu Baulian; Ward Penny
The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):13-9.
-
2001: Seo S K; Regan A; Cihlar T; Lin D C; Boulad F; George D; Prasad V K; Kiehn T E; Polsky B
Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(9):e105-8.
-
2001: Wang Z M; Tong L L; Grant D; Cihlar T
Expression and characterization of soluble human parainfluenza virus type 1 hemagglutinin-neuraminidase glycoprotein.
Journal of virological methods 2001;98(1):53-61.
-
2001: Cihlar T; Ho E S; Lin D C; Mulato A S
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):641-8.
-
2000: Mulato A S; Ho E S; Cihlar T
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
The Journal of pharmacology and experimental therapeutics 2000;295(1):10-5.
-
2000: Cihlar T; Ho E S
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.
Analytical biochemistry 2000;283(1):49-55.
-
2000: Ho E S; Lin D C; Mendel D B; Cihlar T
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.
Journal of the American Society of Nephrology : JASN 2000;11(3):383-93.
-
1999: Cihlar T; Lin D C; Pritchard J B; Fuller M D; Mendel D B; Sweet D H
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
Molecular pharmacology 1999;56(3):570-80.
-
1998: Cihlar T; Fuller M D; Mulato A S; Cherrington J M
A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture.
Virology 1998;248(2):382-93.
-
1998: Miller M D; Lamy P D; Fuller M D; Mulato A S; Margot N A; Cihlar T; Cherrington J M
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity.
Molecular pharmacology 1998;54(2):291-7.
-
1998: Cihlar T; Fuller M D; Cherrington J M
Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments.
Journal of virology 1998;72(7):5927-36.
-
1997: Cihlar T; Fuller M D; Cherrington J M
Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system.
Protein expression and purification 1997;11(2):209-18.
-
1997: Mendel D B; Cihlar T; Moon K; Chen M S
Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase.
Antimicrobial agents and chemotherapy 1997;41(3):641-6.
Sign-in to see more
