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Gennaro Ciliberto

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Enrico Giarnieri; Maria Giovagnoli; Andrea Laurenzi; Salvatore Mariotta; Alessia Noto; Alberto Ricci; Giuseppe Roscilli; Giuseppe Russo; Gerardo Salerno; Pierdonato Bruno; Gennaro Ciliberto; Claudia De Vitis; Rita Mancini
EMT markers in lung adenocarcinoma pleural effusion spheroid cells.
Giuseppe Roscilli; Ottaviano Serlupi-Crescenzi; Ashraf Virmani; Luigi Aurisicchio; Arianna Di Napoli; Rita Mancini; Emanuele Marra; Federica Mori; Gennaro Ciliberto
Carnitines slow down tumor development of colon cancer in the DMH-chemical carcinogenesis mouse model.
Alberto Ricci; Salvatore Sciacchitano; Davide Scozzi; Alessandra Ulivieri; Armando Bartolazzi; Pierdonato Bruno; Emanuela Cherubini; Gennaro Ciliberto; Paolo Graziano; Luca Lavra; Rita Mancini; Salvatore Mariotta
Homeodomain-interacting protein kinase2 in human idiopathic pulmonary fibrosis.

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2013: Enrico Giarnieri; Maria Giovagnoli; Andrea Laurenzi; Salvatore Mariotta; Alessia Noto; Alberto Ricci; Giuseppe Roscilli; Giuseppe Russo; Gerardo Salerno; Pierdonato Bruno; Gennaro Ciliberto; Claudia De Vitis; Rita Mancini
EMT markers in lung adenocarcinoma pleural effusion spheroid cells.
Journal of cellular physiology 2013;228(8):1720-6.
2013: Giuseppe Roscilli; Ottaviano Serlupi-Crescenzi; Ashraf Virmani; Luigi Aurisicchio; Arianna Di Napoli; Rita Mancini; Emanuele Marra; Federica Mori; Gennaro Ciliberto
Carnitines slow down tumor development of colon cancer in the DMH-chemical carcinogenesis mouse model.
Journal of cellular biochemistry 2013;114(7):1665-73.
2013: Alberto Ricci; Salvatore Sciacchitano; Davide Scozzi; Alessandra Ulivieri; Armando Bartolazzi; Pierdonato Bruno; Emanuela Cherubini; Gennaro Ciliberto; Paolo Graziano; Luca Lavra; Rita Mancini; Salvatore Mariotta
Homeodomain-interacting protein kinase2 in human idiopathic pulmonary fibrosis.
Journal of cellular physiology 2013;228(1):235-41.
2012: Luigi Aurisicchio; Fabrizio Carlomosti; Maurizio Alimandi; Claudia De Vitis; Zeynep Gunes; Laura Luberto; Rita Mancini; Emanuele Marra; Giuseppe Mesiti; Alessia Noto; Giuseppe Roscilli; Gennaro Ciliberto
Novel anti-ErbB3 monoclonal antibodies show therapeutic efficacy in xenografted and spontaneous mouse tumors.
Journal of cellular physiology 2012;227(10):3381-8.
2012: Luigi Aurisicchio; Rita Mancini; Emanuele Marra; Giuseppe Roscilli; Gennaro Ciliberto
The promise of anti-ErbB3 monoclonals as new cancer therapeutics.
Oncotarget 2012;3(8):744-58.
2012: Francesca Belleudi; Luigi Aurisicchio; Luigi Fattore; Maria Giovagnoli; Rita Mancini; Emanuele Marra; Francesca Mazzetta; Maria Rosaria Torrisi; Gennaro Ciliberto
Monoclonal antibody-induced ErbB3 receptor internalization and degradation inhibits growth and migration of human melanoma cells.
Cell cycle (Georgetown, Tex.) 2012;11(7):1455-67.
2011: Rita Mancini; Salvatore Mariotta; Emanuele Marra; Giuseppe Mesiti; Alessia Noto; Lara Pisani; Erino A Rendina; Alberto Ricci; Giuseppe Roscilli; Luigi Ruco; Giuseppe Viglietto; Pietro Zoppoli; Andrea Affuso; Claudio Andreetti; Luigi Aurisicchio; Pasquale De Luca; Claudia De Vitis; Arianna Di Napoli; Enrico Giarnieri; Maria Giovagnoli; Carmelo Laudanna; Donatella Malanga; Gennaro Ciliberto
Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment.
PloS one 2011;6(7):e21320.
2011: Zeynep Gunes; Adriana Zucconi; Mario Cioce; Annalisa Meola; Monica Pezzanera; Stefano Acali; Immacolata Zampaglione; Valeria De Pratti; Luca Bova; Fabio Talamo; A Demartis; Paolo MONACI; Nicola La Monica; Gennaro Ciliberto; Alessandra Vitelli
Isolation of Fully Human Antagonistic RON Antibodies Showing Efficient Block of Downstream Signaling and Cell Migration.
Translational oncology 2011;4(1):38-46.
2010: Alberto Ricci; Salvatore Mariotta; Elena Pompili; Rita Mancini; Elena Bronzetti; Claudia De Vitis; Lara Pisani; Emanuela Cherubini; Pierdonato Bruno; Giorgetta Gencarelli; Maria Giovagnoli; Claudio Terzano; Gennaro Ciliberto; Enrico Giarnieri; Lorenzo Fumagalli
Neurotrophin system activation in pleural effusions.
Growth factors (Chur, Switzerland) 2010;28(4):221-31.
2010: Antonella Conforti; Barbara Cipriani; Daniela Peruzzi; Sridhar Dharmapuri; Ekambar R Kandimalla; Sudhir Agrawal; Federica Mori; Gennaro Ciliberto; Nicola La Monica; Luigi Aurisicchio
A TLR9 agonist enhances therapeutic effects of telomerase genetic vaccine.
Vaccine 2010;28(20):3522-30.
2009: Sridhar Dharmapuri; Daniela Peruzzi; Carmela Mennuni; Francesco Calvaruso; Saverio Giampaoli; Gaetano Barbato; Ekambar R Kandimalla; Sudhir Agrawal; Elisa Scarselli; Giuseppe Mesiti; Gennaro Ciliberto; Nicola La Monica; Luigi Aurisicchio
Coadministration of telomerase genetic vaccine and a novel TLR9 agonist in nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(10):1804-13.
2009: Sridhar Dharmapuri; Luigi Aurisicchio; Antonella Biondo; Natalie Welsh; Gennaro Ciliberto; Nicola La Monica
Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model.
Human gene therapy 2009;20(6):589-97.
2009: Luigi Aurisicchio; Daniela Peruzzi; Antonella Conforti; Sridhar Dharmapuri; Antonella Biondo; Saverio Giampaoli; Arthur Fridman; Ansu Bagchi; Christopher T Winkelmann; Raymond Gibson; Ekambar R Kandimalla; Sudhir Agrawal; Gennaro Ciliberto; Nicola La Monica
Treatment of mammary carcinomas in HER-2 transgenic mice through combination of genetic vaccine and an agonist of Toll-like receptor 9.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1575-84.
2009: Daniela Peruzzi; Sridhar Dharmapuri; Agostino Cirillo; Bruno Ercole Bruni; Alfredo Nicosia; Riccardo Cortese; Stefano Colloca; Gennaro Ciliberto; Nicola La Monica; Luigi Aurisicchio
A novel chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines.
Vaccine 2009;27(9):1293-300.
2009: Federica Mori; Patrizia Giannetti; Daniela Peruzzi; Domenico Lazzaro; Saverio Giampaoli; Howard Kaufman; Gennaro Ciliberto; Nicola La Monica; Luigi Aurisicchio
A therapeutic cancer vaccine targeting carcinoembryonic antigen in intestinal carcinomas.
Human gene therapy 2009;20(2):125-36.
2009: Helenia Ansuini; Annalisa Meola; Zeynep Gunes; Valentina Paradisi; Monica Pezzanera; Stefano Acali; Claudia Santini; Alessandra Luzzago; Federica Mori; Domenico Lazzaro; Gennaro Ciliberto; Alfredo Nicosia; Nicola La Monica; alessandra vitelli
Anti-EphA2 Antibodies with Distinct In Vitro Properties Have Equal In Vivo Efficacy in Pancreatic Cancer.
Journal of oncology 2009;2009():951917.
2008: Carmela Mennuni; Stefano Ugel; Federica Mori; Barbara Cipriani; Manuela Iezzi; Tania Pannellini; Lazzaro Domenico; Gennaro Ciliberto; Nicola La Monica; Paola Zanovello; Vincenzo Bronte; Elisa Scarselli
Preventive vaccination with telomerase controls tumor growth in genetically engineered and carcinogen-induced mouse models of cancer.
Cancer research 2008;68(23):9865-74.
2008: Pasquale Gallo; Michael V G Latronico; Paolo Gallo; Serena Grimaldi; Francesco Borgia; Matilde Todaro; Philip Jones; paola gallinari; Raffaele De Francesco; Gennaro Ciliberto; Christian Steinkühler; Giovanni Esposito; Gianluigi Condorelli
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure.
Cardiovascular research 2008;80(3):416-24.
2008: Mirko Arcuri; Manuela Cappelletti; Immacolata Zampaglione; Luigi Aurisicchio; Alfredo Nicosia; Gennaro Ciliberto; Elena Fattori
Synergistic effect of gene-electro transfer and adjuvant cytokines in increasing the potency of hepatitis C virus genetic vaccination.
The journal of gene medicine 2008;10(9):1048-54.
2008: Barbara Cipriani; Arthur Fridman; Claus Bendtsen; Sridhar Dharmapuri; Carmela Mennuni; Irene Pak; Giuseppe Mesiti; Guido Forni; Paolo MONACI; Ansu Bagchi; Gennaro Ciliberto; Nicola La Monica; Elisa Scarselli
Therapeutic vaccination halts disease progression in BALB-neuT mice: the amplitude of elicited immune response is predictive of vaccine efficacy.
Human gene therapy 2008;19(7):670-80.
2007: Andrea Facciabene; Luigi Aurisicchio; Leonardo Elia; Fabio Palombo; Carmela Mennuni; Gennaro Ciliberto; Nicola La Monica
Vectors encoding carcinoembryonic antigen fused to the B subunit of heat-labile enterotoxin elicit antigen-specific immune responses and antitumor effects.
Vaccine 2007;26(1):47-58.
2007: Stefania Lamartina; Monica Cimino; Giuseppe Roscilli; Ernesta Dammassa; Lazzaro Domenico; Rossella Rota; Gennaro Ciliberto; Carlo Toniatti
Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy.
The journal of gene medicine 2007;9(10):862-74.
2007: Luigi Aurisicchio; Carmela Mennuni; Patrizia Giannetti; FRANCESCO CALVARUSO; Maurizio Nuzzo; Barbara Cipriani; Fabio Palombo; Paolo MONACI; Gennaro Ciliberto; Nicola La Monica
Immunogenicity and safety of a DNA prime/adenovirus boost vaccine against rhesus CEA in nonhuman primates.
International journal of cancer. Journal international du cancer 2007;120(11):2290-300.
2007: Leonardo Elia; Luigi Aurisicchio; Andrea Facciabene; Patrizia Giannetti; Gennaro Ciliberto; Nicola La Monica; Fabio Palombo
CD4+CD25+ regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge.
Cancer gene therapy 2007;14(2):201-10.
2006: Stefania Capone; Immacolata Zampaglione; alessandra vitelli; Monica Pezzanera; Lisa S Kierstead; Janine Burns; lionello ruggeri; Mirko Arcuri; Manuela Cappelletti; Annalisa Meola; Bruno Bruni Ercole; Rosalba Tafi; Claudia Santini; Alessandra Luzzago; Tong-Ming Fu; Stefano Colloca; Gennaro Ciliberto; Riccardo Cortese; Alfredo Nicosia; Elena Fattori; Antonella Folgori
Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7462-71.
2006: Olaf Kinzel; Daniela Fattori; Ester Muraglia; paola gallinari; Maria Chiara Nardi; Chantal Paolini; Giuseppe Roscilli; Carlo Toniatti; Odalys Gonzalez Paz; Ralph Laufer; Armin Lahm; Anna Tramontano; Riccardo Cortese; Raffaele De Francesco; Gennaro Ciliberto; Uwe Koch
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.
Journal of medicinal chemistry 2006;49(18):5404-7.
2006: Leonardo Elia; Carmela Mennuni; marianna storto; Silvia Podda; FRANCESCO CALVARUSO; Valentina Salucci; Luigi Aurisicchio; Alessia Scarito; Gennaro Ciliberto; Nicola La Monica; Fabio Palombo
Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: initial identification of predictive biomarkers.
European journal of immunology 2006;36(5):1337-49.
2006: Andrea Facciabene; Luigi Aurisicchio; Leonardo Elia; Fabio Palombo; Carmela Mennuni; Gennaro Ciliberto; Nicola La Monica
DNA and adenoviral vectors encoding carcinoembryonic antigen fused to immunoenhancing sequences augment antigen-specific immune response and confer tumor protection.
Human gene therapy 2006;17(1):81-92.
2006: Valentina Salucci; Carmela Mennuni; FRANCESCO CALVARUSO; Raffaele Cerino; P Neuner; Gennaro Ciliberto; Nicola La Monica; Elisa Scarselli
CD8+ T-cell tolerance can be broken by an adenoviral vaccine while CD4+ T-cell tolerance is broken by additional co-administration of a Toll-like receptor ligand.
Scandinavian journal of immunology 2006;63(1):35-41.
2005: Carmela Mennuni; FRANCESCO CALVARUSO; Andrea Facciabene; Luigi Aurisicchio; marianna storto; Elisa Scarselli; Gennaro Ciliberto; Nicola La Monica
Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA.
International journal of cancer. Journal international du cancer 2005;117(3):444-55.
2005: Immacolata Zampaglione; Mirko Arcuri; Manuela Cappelletti; Gennaro Ciliberto; Gemma Perretta; Alfredo Nicosia; Nicola La Monica; Elena Fattori
In vivo DNA gene electro-transfer: a systematic analysis of different electrical parameters.
The journal of gene medicine 2005;7(11):1475-81.
2005: Valentina Salucci; A M Lena; Gennaro Ciliberto; Elisa Scarselli; Nicola La Monica
Adenovirus transduction and culture conditions affect the immunogenicity of murine dendritic cells.
Scandinavian journal of immunology 2005;62(3):206-17.
2005: paola gallinari; Armin Lahm; Uwe Koch; Chantal Paolini; Maria Chiara Nardi; Giuseppe Roscilli; Olaf Kinzel; Daniela Fattori; Ester Muraglia; Carlo Toniatti; Riccardo Cortese; Raffaele De Francesco; Gennaro Ciliberto
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.
Chemistry & biology 2005;12(8):883-93.
2005: Anna Maria Lena; Patrizia Giannetti; Elisabetta Sporeno; Gennaro Ciliberto; Rocco Savino
Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector.
The journal of gene medicine 2005;7(8):1086-96.
2005: Elisabetta Bianchi; Xiaoping Liang; Paolo Ingallinella; Marco Finotto; Michael A Chastain; Jiang Fan; Tong-Ming Fu; Hong Chang Song; Melanie S Horton; Daniel C Freed; Walter Manger; Emily Wen; Li Shi; Roxana Ionescu; Colleen Price; Marc Wenger; Emilio A Emini; Riccardo Cortese; Gennaro Ciliberto; John W Shiver; Antonello Pessi
Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor.
Journal of virology 2005;79(12):7380-8.
2005: Luigi Aurisicchio; Amedeo De Tomassi; Nicola La Monica; Gennaro Ciliberto; Cinzia Traboni; Fabio Palombo
Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector.
Journal of virology 2005;79(11):6772-80.
2005: Daniele Catalucci; Elisabetta Sporeno; Agostino Cirillo; Gennaro Ciliberto; Alfredo Nicosia; Stefano Colloca
An adenovirus type 5 (Ad5) amplicon-based packaging cell line for production of high-capacity helper-independent deltaE1-E2-E3-E4 Ad5 vectors.
Journal of virology 2005;79(10):6400-9.
2005: Elena Fattori; Manuela Cappelletti; Immacolata Zampaglione; Carmela Mennuni; FRANCESCO CALVARUSO; Mirko Arcuri; Gabriella Rizzuto; Patrizia Costa; Gemma Perretta; Gennaro Ciliberto; Nicola La Monica
Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates.
The journal of gene medicine 2005;7(2):228-36.
2005: Fumi Kinose; Giuseppe Roscilli; Stefania Lamartina; Kenneth C Anderson; Fabio Bonelli; Stan Spence; Gennaro Ciliberto; Thomas F Vogt; Daniel J Holder; Carlo Toniatti; Catherine J Thut
Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor.
Molecular vision 2005;11():366-73.
2004: Carlo Toniatti; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto
Gene therapy progress and prospects: transcription regulatory systems.
Gene therapy 2004;11(8):649-57.
2004: Z Wang; Philip J Troilo; X Wang; Thomas G Griffiths; Stephen J Pacchione; AB Barnum; LB Harper; Cindy J Pauley; Z Niu; L Denisova; T T Follmer; Gabriella Rizzuto; Gennaro Ciliberto; Elena Fattori; N L Monica; S Manam; Brian J Ledwith
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation.
Gene therapy 2004;11(8):711-21.
2003: Gaetano Barbato; Elisabetta Bianchi; Paolo Ingallinella; William H Hurni; Michael D Miller; Gennaro Ciliberto; Riccardo Cortese; Renzo Bazzo; John W Shiver; Antonello Pessi
Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion.
Journal of molecular biology 2003;330(5):1101-15.
2003: Manuela Cappelletti; Immacolata Zampaglione; Gabriella Rizzuto; Gennaro Ciliberto; Nicola La Monica; Elena Fattori
Gene electro-transfer improves transduction by modifying the fate of intramuscular DNA.
The journal of gene medicine 2003;5(4):324-32.
2003: Stefania Lamartina; Luisa Silvi; Giuseppe Roscilli; Danilo R Casimiro; Adam J Simon; Mary-Ellen Davies; John W Shiver; Cira Daniela Rinaudo; Immacolata Zampaglione; Elena Fattori; Stefano Colloca; Odalys Gonzalez Paz; Ralph Laufer; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto; Carlo Toniatti
Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):271-80.
2003: Patrizia Pignatti; Laura Ciapponi; Pia Galle; Morten B Hansen; Margherita Massa; Cristina Meazza; Giacomo Paonessa; D Novick; Gennaro Ciliberto; A Martini; de benedetti fabrizio
High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130.
Clinical and experimental immunology 2003;131(2):355-63.
2002: Maria Teresa Petrucci; Maria R Ricciardi; Chiara Gregorj; Laura Ciapponi; Rocco Savino; Gennaro Ciliberto; Agostino Tafuri
Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells.
Leukemia & lymphoma 2002;43(12):2369-75.
2002: Elena Fattori; Nicola La Monica; Gennaro Ciliberto; Carlo Toniatti
Electro-gene-transfer: a new approach for muscle gene delivery.
Somatic cell and molecular genetics 2002;27(1-6):75-83.
2002: Giuseppe Roscilli; Cira Daniela Rinaudo; Monica Cimino; Elisabetta Sporeno; Stefania Lamartina; Gennaro Ciliberto; Carlo Toniatti
Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):653-63.
2002: Valentina Salucci; Alessia Scarito; Luigi Aurisicchio; Stefania Lamartina; Giancarlo Nicolaus; Saverio Giampaoli; Odalys Gonzalez Paz; Carlo Toniatti; Hermann Bujard; Wolfgang Hillen; Gennaro Ciliberto; Fabio Palombo
Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.
Gene therapy 2002;9(21):1415-21.
2002: Carmela Mennuni; FRANCESCO CALVARUSO; Immacolata Zampaglione; Gabriella Rizzuto; Daniela Rinaudo; Ernesta Dammassa; Gennaro Ciliberto; Elena Fattori; Nicola La Monica
Hyaluronidase increases electrogene transfer efficiency in skeletal muscle.
Human gene therapy 2002;13(3):355-65.
2002: Stefania Lamartina; Giuseppe Roscilli; Cira Daniela Rinaudo; Elisabetta Sporeno; Luisa Silvi; Wolfgang Hillen; Hermann Bujard; Riccardo Cortese; Gennaro Ciliberto; Carlo Toniatti
Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators.
Human gene therapy 2002;13(2):199-210.
2001: Luigi Aurisicchio; Hermann Bujard; Wolfgang Hillen; Riccardo Cortese; Gennaro Ciliberto; Nicola La Monica; Fabio Palombo
Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector.
Gene therapy 2001;8(24):1817-25.
2001: Domenico Maione; Carlo Della Rocca; Patrizia Giannetti; R D'Arrigo; L Liberatoscioli; Laura L Franlin; V Sandig; Gennaro Ciliberto; Nicola La Monica; Rocco Savino
An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):5986-91.
2001: de benedetti fabrizio; Patrizia Pignatti; Marina Vivarelli; Cristina Meazza; Gennaro Ciliberto; Rocco Savino; Alberto Martini
In vivo neutralization of human IL-6 (hIL-6) achieved by immunization of hIL-6-transgenic mice with a hIL-6 receptor antagonist.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4334-40.
2001: Laura Santodonato; Maria Ferrantini; Fabio Palombo; Luigi Aurisicchio; Paola Delmastro; Nicola La Monica; S Di Marco; Gennaro Ciliberto; MX Du; Milton Taylor; Filippo Belardelli
Antitumor activity of recombinant adenoviral vectors expressing murine IFN-alpha in mice injected with metastatic IFN-resistant tumor cells.
Cancer gene therapy 2001;8(1):63-72.
2000: Stefania Lamartina; Gennaro Ciliberto; Carlo Toniatti
Selective cleavage of AAVS1 substrates by the adeno-associated virus type 2 rep68 protein is dependent on topological and sequence constraints.
Journal of virology 2000;74(19):8831-42.
2000: Gabriella Rizzuto; Manuela Cappelletti; Carmela Mennuni; M Wiznerowicz; A Demartis; Domenico Maione; Gennaro Ciliberto; Nicola La Monica; Elena Fattori
Gene electrotransfer results in a high-level transduction of rat skeletal muscle and corrects anemia of renal failure.
Human gene therapy 2000;11(13):1891-900.
2000: Annalise Di Marco; A Demartis; I Gloaguen; Lazzaro Domenico; Paola Delmastro; Gennaro Ciliberto; Ralph Laufer
Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin.
European journal of biochemistry / FEBS 2000;267(10):2939-44.
2000: Luigi Aurisicchio; Paola Delmastro; Valentina Salucci; O G Paz; P Rovere; Gennaro Ciliberto; Nicola La Monica; Fabio Palombo
Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis.
Journal of virology 2000;74(10):4816-23.
2000: Domenico Maione; M Wiznerowicz; Paola Delmastro; Riccardo Cortese; Gennaro Ciliberto; Nicola La Monica; Rocco Savino
Prolonged expression and effective readministration of erythropoietin delivered with a fully deleted adenoviral vector.
Human gene therapy 2000;11(6):859-68.
2000: Daniela Rinaudo; Stefania Lamartina; Giuseppe Roscilli; Gennaro Ciliberto; Carlo Toniatti
Conditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.
Journal of virology 2000;74(1):281-94.
1999: Gabriella Rizzuto; Manuela Cappelletti; Domenico Maione; Rocco Savino; Lazzaro Domenico; Patrizia Costa; Iacob Mathiesen; Riccardo Cortese; Gennaro Ciliberto; Ralph Laufer; Nicola La Monica; Elena Fattori
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6417-22.
1999: A Recchia; R J Parks; Stefania Lamartina; Carlo Toniatti; L Pieroni; Fabio Palombo; Gennaro Ciliberto; F L Graham; Riccardo Cortese; Nicola La Monica; Stefano Colloca
Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2615-20.
1999: Gabriella Rizzuto; Barbara Gorgoni; Manuela Cappelletti; Lazzaro Domenico; I Gloaguen; V Poli; Antonella Sgura; Daniela Cimini; Gennaro Ciliberto; Riccardo Cortese; Elena Fattori; Nicola La Monica
Development of animal models for adeno-associated virus site-specific integration.
Journal of virology 1999;73(3):2517-26.
1999: Maria Teresa Petrucci; Maria R Ricciardi; Cristina Ariola; Chiara Gregorj; Michela Ribersani; Rocco Savino; Gennaro Ciliberto; Agostino Tafuri
Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1.
Annals of hematology 1999;78(1):13-8.
1999: Robyn Catlett-Falcone; Terry Landowski; MM Oshiro; James Turkson; Alexander Levitzki; Rocco Savino; Gennaro Ciliberto; Lynn Moscinski; J L Fernández-Luna; G Nuñez; William S Dalton; Richard Jove
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.
Immunity 1999;10(1):105-15.
1999: Daniela Frasca; Gino Doria; Paola Barattini; F Guidi; A L Salvati; Carlo Toniatti; Gennaro Ciliberto
Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation.
European journal of immunology 1999;29(1):300-10.
1999: N Borsellino; B Bonavida; Gennaro Ciliberto; Carlo Toniatti; Salvatore Travali; Natale D'Alessandro
Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity.
Cancer 1999;85(1):134-44.
1998: Giovanna Liuzzo; Antonino Buffon; Luigi M Biasucci; JR Gallimore; giuseppina caligiuri; alessandra vitelli; Sergio Altamura; Gennaro Ciliberto; Antonio G Rebuzzi; Filippo Crea; M B Pepys; Attilio Maseri
Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina.
Circulation 1998;98(22):2370-6.
1998: Domenico Maione; E Di Carlo; W Li; P Musiani; A Modesti; M Peters; S Rose-John; Carlo Della Rocca; M Tripodi; Lazzaro Domenico; R Taub; Rocco Savino; Gennaro Ciliberto
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.
The EMBO journal 1998;17(19):5588-97.
1998: Peter Schirmacher; M Peters; Gennaro Ciliberto; Manfred Blessing; Johannes Lotz; Karl-Hermann Meyer zum Büschenfelde; Stefan Rose-John
Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.
The American journal of pathology 1998;153(2):639-48.
1998: Fabio Palombo; A Monciotti; A Recchia; Riccardo Cortese; Gennaro Ciliberto; Nicola La Monica
Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector.
Journal of virology 1998;72(6):5025-34.
1998: Heike Dahmen; U Horsten; Andrea Küster; Yannick Jacques; Stéphane Minvielle; Ian M Kerr; Gennaro Ciliberto; Giacomo Paonessa; Peter C Heinrich; Gerhard Müller-Newen
Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.
The Biochemical journal 1998;331 ( Pt 3)():695-702.
1998: Renate Burger; Frank Neipel; Bernhard Fleckenstein; Rocco Savino; Gennaro Ciliberto; Joachim R Kalden; Martin Gramatzki
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells.
Blood 1998;91(6):1858-63.
1998: Tonino Alonzi; Elena Fattori; Lazzaro Domenico; Patrizia Costa; L Probert; george kollias; de benedetti fabrizio; Valeria Poli; Gennaro Ciliberto
Interleukin 6 is required for the development of collagen-induced arthritis.
The Journal of experimental medicine 1998;187(4):461-8.
1998: Tonino Alonzi; Elena Fattori; Manuela Cappelletti; Gennaro Ciliberto; Valeria Poli
Impaired Stat3 activation following localized inflammatory stimulus in IL-6-deficient mice.
Cytokine 1998;10(1):13-8.
1997: Laura Ciapponi; Domenico Maione; A Scoumanne; Patrizia Costa; Morten B Hansen; Morten Svenson; Klaus Bendtzen; Tonino Alonzi; Giacomo Paonessa; Riccardo Cortese; Gennaro Ciliberto; Rocco Savino
Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.
Nature biotechnology 1997;15(10):997-1001.
1997: Giuseppe Lattanzio; C Libert; M Aquilina; Manuela Cappelletti; Gennaro Ciliberto; Piero Musiani; V Poli
Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice.
The American journal of pathology 1997;151(3):689-96.
1997: Isabella Saggio; Laura Ciapponi; Rocco Savino; Gennaro Ciliberto; Michel Perricaudet
Adenovirus-mediated gene transfer of a human IL-6 antagonist.
Gene therapy 1997;4(8):839-45.
1997: M Peters; M Odenthal; Peter Schirmacher; Manfred Blessing; Elena Fattori; Gennaro Ciliberto; K H Meyer zum Buschenfelde; Stefan Rose-John
Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1474-81.
1997: I Gloaguen; Patrizia Costa; A Demartis; Lazzaro Domenico; Annalise Di Marco; Rita Graziani; Giacomo Paonessa; F Chen; C I Rosenblum; L H Van der Ploeg; Riccardo Cortese; Gennaro Ciliberto; Ralph Laufer
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6456-61.
1997: M Romano; Marina Sironi; Carlo Toniatti; Nadia Polentarutti; P Fruscella; Pietro Ghezzi; R Faggioni; Walter Luini; V van Hinsbergh; Silvano Sozzani; Federico Bussolino; Valeria Poli; Gennaro Ciliberto; Alberto Mantovani
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.
Immunity 1997;6(3):315-25.
1997: M Peters; Peter Schirmacher; J Goldschmitt; M Odenthal; Christian Peschel; Elena Fattori; Gennaro Ciliberto; Hans P Dienes; Karl-Hermann Meyer zum Büschenfelde; Stefan Rose-John
Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice.
The Journal of experimental medicine 1997;185(4):755-66.
1997: de benedetti fabrizio; Tonino Alonzi; A Moretta; Lazzaro Domenico; P Costa; Valeria Poli; A Martini; Gennaro Ciliberto; Elena Fattori
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.
The Journal of clinical investigation 1997;99(4):643-50.
1996: Petra Neddermann; Rita Graziani; Gennaro Ciliberto; Giacomo Paonessa
Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.
The Journal of biological chemistry 1996;271(48):30986-91.
1996: E Di Santo; Tonino Alonzi; Elena Fattori; Valeria Poli; Gennaro Ciliberto; Marina Sironi; P Gnocchi; Paola Ricciardi-Castagnoli; Pietro Ghezzi
Overexpression of interleukin-6 in the central nervous system of transgenic mice increases central but not systemic proinflammatory cytokine production.
Brain research 1996;740(1-2):239-44.
1996: A Demartis; Francesca Bernassola; Rocco Savino; Gerry Melino; Gennaro Ciliberto
Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death.
Cancer research 1996;56(18):4213-8.
1996: Luigi M Biasucci; alessandra vitelli; Giovanna Liuzzo; Sergio Altamura; giuseppina caligiuri; C Monaco; Antonio G Rebuzzi; Gennaro Ciliberto; Attilio Maseri
Elevated levels of interleukin-6 in unstable angina.
Circulation 1996;94(5):874-7.
1996: Carlo Toniatti; A Cabibbo; E Sporena; A L Salvati; M Cerretani; S Serafini; Armin Lahm; Riccardo Cortese; Gennaro Ciliberto
Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.
The EMBO journal 1996;15(11):2726-37.
1996: E Sporeno; Rocco Savino; Laura Ciapponi; Giacomo Paonessa; A Cabibbo; Armin Lahm; K Pulkki; R X Sun; Carlo Toniatti; B Klein; Gennaro Ciliberto
Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells.
Blood 1996;87(11):4510-9.
1996: F Martin; Carlo Toniatti; A L Salvati; Gennaro Ciliberto; Riccardo Cortese; maurizio sollazzo
Coupling protein design and in vitro selection strategies: improving specificity and affinity of a designed beta-protein IL-6 antagonist.
Journal of molecular biology 1996;255(1):86-97.
1995: A Cabibbo; E Sporeno; Carlo Toniatti; Sergio Altamura; Rocco Savino; Giacomo Paonessa; Gennaro Ciliberto
Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix.
Gene 1995;167(1-2):41-7.
1995: Laura Ciapponi; Rita Graziani; Giacomo Paonessa; Armin Lahm; Gennaro Ciliberto; Rocco Savino
Definition of a composite binding site for gp130 in human interleukin-6.
The Journal of biological chemistry 1995;270(52):31249-54.
1995: A De Serio; Rita Graziani; Ralph Laufer; Gennaro Ciliberto; Giacomo Paonessa
In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex.
Journal of molecular biology 1995;254(5):795-800.
1995: Elena Fattori; Lazzaro Domenico; Piero Musiani; Andrea Modesti; Tonino Alonzi; Gennaro Ciliberto
IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage.
The European journal of neuroscience 1995;7(12):2441-9.
1995: Stefano Casola; Paola Ungaro; Paolo V Pedone; Lazzaro Domenico; Elena Fattori; Gennaro Ciliberto; Raffaele Zarrilli; Carmelo B Bruni; Andrea Riccio
Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.
Oncogene 1995;11(4):711-21.
1995: Armin Lahm; Rocco Savino; A L Salvati; A Cabibbo; Laura Ciapponi; A Demartis; Carlo Toniatti; Giacomo Paonessa; Sergio Altamura; Gennaro Ciliberto
The molecular design of human IL-6 receptor antagonists.
Annals of the New York Academy of Sciences 1995;762():136-50; discussion 150-1.
1995: A L Salvati; Armin Lahm; Giacomo Paonessa; Gennaro Ciliberto; Carlo Toniatti
Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.
The Journal of biological chemistry 1995;270(20):12242-9.
1995: Giacomo Paonessa; Rita Graziani; A De Serio; Rocco Savino; Laura Ciapponi; Armin Lahm; A L Salvati; Carlo Toniatti; Gennaro Ciliberto
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
The EMBO journal 1995;14(9):1942-51.
1994: Rocco Savino; Laura Ciapponi; Armin Lahm; A Demartis; A Cabibbo; Carlo Toniatti; P Delmastro; Sergio Altamura; Gennaro Ciliberto
Rational design of a receptor super-antagonist of human interleukin-6.
The EMBO journal 1994;13(24):5863-70.
1994: F Martin; Carlo Toniatti; A L Salvati; S Venturini; Gennaro Ciliberto; Riccardo Cortese; maurizio sollazzo
The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6.
The EMBO journal 1994;13(22):5303-9.
1994: E Sporeno; Giacomo Paonessa; A L Salvati; Rita Graziani; P Delmastro; Gennaro Ciliberto; Carlo Toniatti
Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors.
The Journal of biological chemistry 1994;269(15):10991-5.
1994: B Gregory; Rocco Savino; Gennaro Ciliberto
A fast and sensitive colorimetric assay for IL-6 in hepatoma cells based on the production of a secreted form of alkaline phosphatase (SEAP).
Journal of immunological methods 1994;170(1):47-56.
1994: Rocco Savino; Armin Lahm; A L Salvati; Laura Ciapponi; E Sporeno; Sergio Altamura; Giacomo Paonessa; Carlo Toniatti; Gennaro Ciliberto
Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
The EMBO journal 1994;13(6):1357-67.
1994: Valeria Poli; R Balena; Elena Fattori; A Markatos; M Yamamoto; H Tanaka; Gennaro Ciliberto; G A Rodan; F Costantini
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.
The EMBO journal 1994;13(5):1189-96.
1994: A Wallace; Sergio Altamura; Carlo Toniatti; alessandra vitelli; Elisabetta Bianchi; P Delmastro; Gennaro Ciliberto; Antonello Pessi
A Multimeric Synthetic Peptide Combinatorial Library.
Peptide research 1994;7(1):27-31.
1993: Rocco Savino; Armin Lahm; M Giorgio; A Cabibbo; A Tramontano; Gennaro Ciliberto
Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4067-71.
1993: Carlo Toniatti; Paolo MONACI; Alfredo Nicosia; Riccardo Cortese; Gennaro Ciliberto
A bipartite activation domain is responsible for the activity of transcription factor HNF1/LFB1 in cells of hepatic and nonhepatic origin.
DNA and cell biology 1993;12(3):199-208.
1993: D P Ramji; alessandra vitelli; F Tronche; Riccardo Cortese; Gennaro Ciliberto
The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms.
Nucleic acids research 1993;21(2):289-94.
1990: Carlo Toniatti; A Demartis; Paolo MONACI; Alfredo Nicosia; Gennaro Ciliberto
Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.
The EMBO journal 1990;9(13):4467-75.