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Leena Alhonen

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Mervi T Hyvönen; Alex R Khomutov; Jouko Vepsäläinen; Janne Weisell; Leena Alhonen; Tuomo A Keinänen
Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.
Olga A Smirnova; Vera L Tunitskaya; Jouko Vepsalainen; Tuomo Keinanen; Sergey N Kochetkov; Leena Alhonen; Mervi T Hyvonen; Maria G Isaguliants; Alexander V Ivanov
Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.
Marc Cerrada-Gimenez; M Moya; Eija Pirinen; M Tusa; F Bosch; A Casellas; Leena Alhonen
Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism.

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2013: Mervi T Hyvönen; Alex R Khomutov; Jouko Vepsäläinen; Janne Weisell; Leena Alhonen; Tuomo A Keinänen
Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):30-2.
2012: Olga A Smirnova; Vera L Tunitskaya; Jouko Vepsalainen; Tuomo Keinanen; Sergey N Kochetkov; Leena Alhonen; Mervi T Hyvonen; Maria G Isaguliants; Alexander V Ivanov
Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.
Biochimie 2012;94(9):1876-83.
2012: Marc Cerrada-Gimenez; M Moya; Eija Pirinen; M Tusa; F Bosch; A Casellas; Leena Alhonen
Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism.
Transgenic research 2012;21(4):843-53.
2012: Jan Van den Bossche; Eva Van Overmeire; Lars Vereecke; Leena Alhonen; Lea Brys; Patrick De Baetselier; Jan M C Geuns; Eleonore S Koehler; Wouter H Lamers; Yannick Morias; Sini Pirnes-Karhu; Anne Uimari; Jo A Van Ginderachter
Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.
Journal of leukocyte biology 2012;91(5):685-99.
2012: Mervi T Hyvönen; Tuomo A Keinänen; Maxim Khomutov; Alex R Khomutov; Jong Hwan Park; Alina Simonian; Jouko Vepsäläinen; Leena Alhonen; Myung Hee Park
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
Amino acids 2012;42(2-3):685-95.
2012: Irina Nayvelt; Rajesh Patel; Akira Shirahata; Thresia Thomas; Leena Alhonen; Gokul Das; Hui-Chen Hsu; Mervi T Hyvönen; Shali John; Tuomo A Keinänen; Wensheng Liu; Pingar Yang; T J Thomas
A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.
Amino acids 2012;42(2-3):899-911.
2012: Marc Cerrada-Gimenez; Merja R Häkkinen; Leena Alhonen; Seppo Auriola; Jouko Vepsäläinen; Tuomo A Keinänen
Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS.
Amino acids 2012;42(2-3):451-60.
2012: Taina Koponen; Leena Alhonen; Marc Cerrada-Gimenez; Sami Heikkinen; Esa Hohtola; Jussi Paananen; Eija Pirinen; Sini Pirnes-Karhu; Maija Tusa; Anne Uimari; Antti Virkamäki; Susanna Vuohelainen; Markku Laakso
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.
Amino acids 2012;42(2-3):427-40.
2012: Anne Uimari; Mari Merentie; Sirpa Peräniemi; Sini Pirnes-Karhu; Reijo Sironen; Leena Alhonen
Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse.
Amino acids 2012;42(2-3):461-71.
2012: Sini Pirnes-Karhu; Reijo Sironen; Leena Alhonen; Anne Uimari
Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.
Amino acids 2012;42(2-3):473-84.
2012: Mervi T Hyvönen; Tuomo A Keinänen; Alex R Khomutov; Anne Uimari; Jouko Vepsäläinen; Leena Alhonen
Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.
Amino acids 2012;42(2-3):485-93.
2012: Marko Pietilä; Anita Lampinen; Riikka Pellinen; Leena Alhonen
Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer.
Amino acids 2012;42(2-3):559-64.
2011: Marc Cerrada-Gimenez; Myung Hee Park; Mervi T Hyvönen; Jouko Vepsäläinen; Janne Weisell; Leena Alhonen; Tuomo A Keinänen
Complex N-acetylation of triethylenetetramine.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2242-9.
2011: György Biczó; Sándor Dósa; Anna S Gukovskaya; Péter Hegyi; Zsuzsanna Hracsko; Béla Iványi; Katalin Jármay; Zoltán Kukor; Natalia Shalbuyeva; Riitta Sinervirta; Andrea Siska; Tamás Takács; Ilona S Varga; Viktória Venglovecz; Tibor Wittmann; Leena Alhonen; Sándor Berczi; Zoltán Rakonczay
The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis.
Antioxidants & redox signaling 2011;15(10):2669-81.
2011: Mervi T Hyvönen; Tuomo A Keinänen; Leena Alhonen; Maxim Khomutov; Sergey N Kochetkov; Alina Simonian; Jouko Vepsäläinen; Janne Weisell; Alex R Khomutov
The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.
Journal of medicinal chemistry 2011;54(13):4611-8.
2011: Marc Cerrada-Gimenez; Marko Pietilä; Suvikki Loimas; Eija Pirinen; Mervi T Hyvönen; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Transgenic research 2011;20(2):387-96.
2011: Hai-Tao Jin; Alex R Khomutov; Teemu Lämsä; Isto Nordback; Panu H Nordback; Ilkka Pörsti; Sari Räty; Leena Alhonen; Nikolay Grigorenko; Mervi T Hyvönen; Juhani Sand
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
Pharmacological reports : PR 2011;63(4):999-1008.
2011: Hai-Tao Jin; Teemu Lämsä; Isto Nordback; Panu H Nordback; Sari Räty; Leena Alhonen; Karl-Heinz Herzig; Mervi T Hyvönen; Juhani Sand
Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2011;11(2):83-91.
2011: Alex R Khomutov; Janne Weisell; Maxim A Khomutov; Nikolay A Grigorenko; Alina R Simonian; Merja R Häkkinen; Tuomo A Keinänen; Mervi T Hyvönen; Leena Alhonen; Sergey N Kochetkov; Jouko Vepsäläinen
Methylated polyamines as research tools.
Methods in molecular biology (Clifton, N.J.) 2011;720():449-61.
2011: Anne Uimari; Mervi T Hyvönen; Eija Pirinen; Leena Alhonen
Transgenic rodents with altered SSAT expression as models of pancreatitis and altered glucose and lipid metabolism.
Methods in molecular biology (Clifton, N.J.) 2011;720():143-58.
2010: Maija Bry; Riikka Kivelä; Tanja Holopainen; Andrey Anisimov; Tuomas Tammela; Jarkko Soronen; Johanna Silvola; Antti Saraste; Michael Jeltsch; Petra Korpisalo; Peter Carmeliet; Karl B Lemström; Masabumi Shibuya; Seppo Ylä-Herttuala; Leena Alhonen; Eero Mervaala; Leif C Andersson; Juhani Knuuti; Kari Alitalo
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.
Circulation 2010;122(17):1725-33.
2010: György Biczó; Péter Hegyi; Riitta Sinervirta; Sándor Berczi; Sándor Dósa; Andrea Siska; Béla Iványi; Viktória Venglovecz; Tamás Takács; Leena Alhonen; Zoltán Rakonczay
Characterization of polyamine homeostasis in l-ornithine-induced acute pancreatitis in rats.
Pancreas 2010;39(7):1047-56.
2010: Yuval Ramot; Marko Pietilä; giammaria giuliani; Fabio Rinaldi; Leena Alhonen; Ralf Paus
Polyamines and hair: a couple in search of perfection.
Experimental dermatology 2010;19(9):784-90.
2010: Janne Weisell; Mervi T Hyvönen; Merja R Häkkinen; Nikolay A Grigorenko; Marko Pietilä; Anita Lampinen; Sergey N Kochetkov; Leena Alhonen; Jouko Vepsäläinen; Tuomo A Keinänen; Alex R Khomutov
Synthesis and biological characterization of novel charge-deficient spermine analogues.
Journal of medicinal chemistry 2010;53(15):5738-48.
2010: Kamyar Zahedi; Sharon Barone; Debora L Kramer; Hassane Amlal; Leena Alhonen; Juhani Jänne; Carl W Porter; Manoocher Soleimani
The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.
American journal of physiology. Cell physiology 2010;299(1):C164-74.
2010: Susanna Vuohelainen; Eija Pirinen; Marc Cerrada-Gimenez; Tuomo A Keinänen; Anne Uimari; Marko Pietilä; Alex R Khomutov; Juhani Jänne; Leena Alhonen
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine 2010;14(6B):1683-92.
2010: K A Mäkelä; Henna-Kaisa Wigren; J C Zant; T Sakurai; Leena Alhonen; A Kostin; T Porkka-Heiskanen; K-H Herzig
Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin.
Acta physiologica (Oxford, England) 2010;198(3):237-49.
2010: Marc Cerrada-Gimenez; Jukka Häyrinen; Sisko Juutinen; Tuula Reponen; Juhani Jänne; Leena Alhonen
Proteomic analysis of livers from a transgenic mouse line with activated polyamine catabolism.
Amino acids 2010;38(2):613-22.
2010: Merja R Häkkinen; Mervi T Hyvönen; Seppo Auriola; Robert A Casero; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Tuomo A Keinänen
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.
Amino acids 2010;38(2):369-81.
2010: Eija Pirinen; Helena Gylling; Paula Itkonen; Nagendra Yaluri; Sami Heikkinen; Marko Pietilä; Teemu Kuulasmaa; Maija Tusa; Marc Cerrada-Gimenez; Jussi Pihlajamäki; Leena Alhonen; Juhani Jänne; Tatu A Miettinen; Markku Laakso
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.
Amino acids 2010;38(2):549-60.
2010: Mervi T Hyvönen; Riitta Sinervirta; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Tuomo A Keinänen; Leena Alhonen
alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage.
Amino acids 2010;38(2):575-81.
2010: Tekele Markos Fashe; Tuomo A Keinänen; Nikolay Grigorenko; Alex R Khomutov; Juhani Jänne; Leena Alhonen; Marko Pietilä
Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.
Amino acids 2010;38(2):583-90.
2010: Janne Weisell; Mervi T Hyvönen; Jouko Vepsäläinen; Leena Alhonen; Tuomo A Keinänen; Alex R Khomutov; Pasi Soininen
Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.
Amino acids 2010;38(2):501-7.
2010: Irina Nayvelt; Mervi T Hyvönen; Leena Alhonen; Ipsit Pandya; Thresia Thomas; Alex R Khomutov; Jouko Vepsäläinen; Rajesh Patel; Tuomo A Keinänen; Thekkumkat John Thomas
DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.
Biomacromolecules 2010;11(1):97-105.
2010: Mervi T Hyvönen; Riitta Sinervirta; Tuomo A Keinänen; Tekele Markos Fashe; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Leena Alhonen
Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2010;10(2-3):208-21.
2010: Wanda Carolina Leon; Fabio Canneva; Vanessa Partridge; Simon Allard; Maria Teresa Ferretti; Arald DeWilde; Freya Vercauteren; Ramtin Atifeh; Adriana Ducatenzeiler; William L Klein; Moshe Szyf; Leena Alhonen; A Claudio Cuello
A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.
Journal of Alzheimer's disease : JAD 2010;20(1):113-26.
2009: Mervi T Hyvönen; Michael T Howard; Christine B Anderson; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Leena Alhonen; Juhani Jänne; Tuomo A Keinänen
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.
The Biochemical journal 2009;422(2):321-8.
2009: Anne Uimari; Tuomo A Keinänen; Anne Karppinen; Patrick M Woster; Pekka Uimari; Juhani Jänne; Leena Alhonen
Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.
The Biochemical journal 2009;422(1):101-9.
2009: Kamyar Zahedi; Alex B Lentsch; Tomohisa Okaya; Sharon Barone; Nozomu Sakai; David P Witte; Lois J Arend; Leena Alhonen; Jason Jell; Juhani Jänne; Carl W Porter; Manoocher Soleimani
Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G899-909.
2009: Leena Alhonen; Anne Uimari; Marko Pietilä; Mervi T Hyvönen; Eija Pirinen; Tuomo A Keinänen
Transgenic animals modelling polyamine metabolism-related diseases.
Essays in biochemistry 2009;46():125-44.
2009: Hai-Tao Jin; Sari Räty; Minna Minkkinen; Satu Järvinen; Juhani Sand; Leena Alhonen; Isto Nordback
Changes in blood polyamine levels in human acute pancreatitis.
Scandinavian journal of gastroenterology 2009;44(8):1004-11.
2008: Merja R Häkkinen; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Juhani Jänne; Seppo Auriola
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.
Journal of pharmaceutical and biomedical analysis 2008;48(2):414-21.
2008: S Oikari; T Ahtialansaari; A Huotari; Karlheinz Kiehne; Ulrich R Fölsch; S Wolffram; Juhani Jänne; Leena Alhonen; Karl-Heinz Herzig
Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats.
Acta physiologica (Oxford, England) 2008;194(1):57-65.
2008: Hai-Tao Jin; Teemu Lämsä; Mervi T Hyvönen; Juhani Sand; Sari Räty; Nikolay Grigorenko; Alex R Khomutov; Karl-Heinz Herzig; Leena Alhonen; Isto Nordback
A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.
Surgery 2008;144(1):49-56.
2008: Sanna Oikari; Tiia Ahtialansaari; Miika V Heinonen; Timo Mauriala; Seppo Auriola; Karlheinz Kiehne; Ulrich R Fölsch; Juhani Jänne; Leena Alhonen; Karl-Heinz Herzig
Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.
Pflügers Archiv : European journal of physiology 2008;456(2):369-77.
2008: Hai-Tao Jin; Teemu Lamsa; Mari Merentie; Mervi T Hyvonen; Juhani Sand; Sari Raty; Karl-Heinz Herzig; Leena Alhonen; Isto Nordback
Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2008;8(1):15-24.
2007: Merja R Häkkinen; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Juhani Jänne; Seppo Auriola
Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2007;45(4):625-34.
2007: Mervi T Hyvönen; Tuomo A Keinänen; Marc Cerrada-Gimenez; Riitta Sinervirta; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Leena Alhonen; Juhani Jänne
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
The Journal of biological chemistry 2007;282(48):34700-6.
2007: Tuomo A Keinänen; Aki Järvinen; Anne Uimari; Jouko Vepsäläinen; Alex R Khomutov; Nikolay Grigorenko; Mervi T Hyvönen; Marc Cerrada-Gimenez; Leena Alhonen; Juhani Jänne
Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.
Mini reviews in medicinal chemistry 2007;7(8):813-20.
2007: M Merentie; Anne Uimari; Marko Pietilä; Riitta Sinervirta; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Nikolay Grigorenko; Karl-Heinz Herzig; Juhani Jänne; Leena Alhonen
Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.
Amino acids 2007;33(2):323-30.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Mervi T Hyvönen; M Merentie; Anne Uimari; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Mechanisms of polyamine catabolism-induced acute pancreatitis.
Biochemical Society transactions 2007;35(Pt 2):326-30.
2007: Olivier Raisky; Antti I Nykänen; Rainer Krebs; Maria Hollmén; Mikko A I Keränen; Jussi M Tikkanen; Roope K Sihvola; Leena Alhonen; Petri Salven; Yan Wu; Daniel J Hicklin; Kari Alitalo; Petri K Koskinen; Karl B Lemström
VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):819-25.
2007: Jason Jell; Salim Merali; Mary L Hensen; richard mazurchuk; Joseph Spernyak; Paula Diegelman; Nicholas Kisiel; Carlos Barrero; Kristin K Deeb; Leena Alhonen; Mulchand S Patel; Carl W Porter
Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.
The Journal of biological chemistry 2007;282(11):8404-13.
2007: Hanna Siiskonen; Sanna Oikari; Veli-Pekka Korhonen; Asla Pitkänen; Vootele Voikar; Mikko I Kettunen; Juhana M Hakumäki; Tiina Wahlfors; Raimo Pussinen; Markku Penttonen; Karlheinz Kiehne; Selma K Kaasinen; Leena Alhonen; Juhani Jänne; Karl-Heinz Herzig
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning.
Molecular and cellular neurosciences 2007;34(2):199-208.
2007: Alina Simonian; Alex R Khomutov; Tapani Hyvonen; Nikolay Grigorenko; Tuomo Keinanen; Jouko Vepsalainen; Leena Alhonen; Juhani Janne
Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1245-8.
2006: Kirsi Niiranen; Tuomo A Keinänen; Eija Pirinen; Sami Heikkinen; Maija Tusa; Szabolcs Fatrai; Suvikki Suppola; Marko Pietilä; Anne Uimari; Markku Laakso; Leena Alhonen; Juhani Jänne
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Anne Höytö; A-P Sihvonen; Leena Alhonen; Jukka Juutilainen; Jonne Naarala
Modest increase in temperature affects ODC activity in L929 cells: Low-level radiofrequency radiation does not.
Radiation and environmental biophysics 2006;45(3):231-5.
2006: Mervi T Hyvönen; Anne Uimari; Tuomo A Keinänen; Sami Heikkinen; Riikka Pellinen; Tiina Wahlfors; Arja Korhonen; Ale Närvänen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.
RNA (New York, N.Y.) 2006;12(8):1569-82.
2006: Tiina Wahlfors; Anne Karppinen; Juhani Jänne; Leena Alhonen; Jarmo Wahlfors
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
International journal of oncology 2006;28(6):1515-22.
2006: Tiina Wahlfors; Tanja Hakkarainen; Juhani Jänne; Leena Alhonen; Jarmo Wahlfors
In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.
International journal of cancer. Journal international du cancer 2006;118(11):2907-10.
2006: Aki Järvinen; Tuomo A Keinänen; Nikolay Grigorenko; Alex R Khomutov; Anne Uimari; Jouko Vepsäläinen; Ale Närvänen; Leena Alhonen; Juhani Jänne
Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.
The Journal of biological chemistry 2006;281(8):4589-95.
2006: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen; Anne Uimari; Mervi T Hyvönen; Eija Pirinen; Aki Järvinen
Genetic manipulation of polyamine catabolism in rodents.
Journal of biochemistry 2006;139(2):155-60.
2006: Aki Järvinen; Marc Cerrada-Gimenez; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Riitta Sinervirta; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.
Journal of medicinal chemistry 2006;49(1):399-406.
2006: Pia Leppänen; Ivana Kholová; Anssi J Mähönen; Kari J Airenne; Suvi Koota; Hannu Mansukoski; Johanna Närväinen; Maria Wirzenius; Leena Alhonen; Juhani Jänne; Kari Alitalo; Seppo Ylä-Herttuala
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2006: Mervi T Hyvönen; Karl-Heinz Herzig; Riitta Sinervirta; Elke Albrecht; Isto Nordback; Juhani Sand; Tuomo A Keinänen; Jouko Vepsäläinen; Nikolay Grigorenko; Alex R Khomutov; Burkhard Krüger; Juhani Jänne; Leena Alhonen
activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.
The American journal of pathology 2006;168(1):115-22.
2005: Juhani Jänne; Leena Alhonen; Tuomo A Keinänen; Marko Pietilä; Anne Uimari; Eija Pirinen; Mervi T Hyvönen; Aki Järvinen
Animal disease models generated by genetic engineering of polyamine metabolism.
Journal of cellular and molecular medicine 2005;9(4):865-82.
2005: Rikke Christensen; Leena Alhonen; Jarmo Wahlfors; Maria Jakobsen; Thomas G Jensen
Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin.
Experimental dermatology 2005;14(7):535-42.
2005: Jody M Tucker; John T Murphy; Nicholas Kisiel; Paula Diegelman; Karen W Barbour; Celestia Davis; Moussumi Medda; Leena Alhonen; Juhani Jänne; Debora L Kramer; Carl W Porter; Franklin G Berger
Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.
Cancer research 2005;65(12):5390-8.
2005: Alex R Khomutov; Alina Simonian; J Vespalainen; Tuomo Keinanen; Leena Alhonen; Juhani Janne
[New oxaanalogues of spermine].
Bioorganicheskaia khimiia 2005;31(2):206-12.
2005: Nikolay Grigorenko; Jouko Vepsalainen; A Jarvinen; Tuomo Keinanen; Leena Alhonen; Juhani Janne; Alex R Khomutov
[New syntheses of alpha-methyl- and alpha,alpha'-dimethylspermine].
Bioorganicheskaia khimiia 2005;31(2):200-5.
2005: Marko Pietilä; Eija Pirinen; Salla Keskitalo; Sisko Juutinen; Sanna Pasonen-Seppänen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
The Journal of investigative dermatology 2005;124(3):596-601.
2005: Aki Järvinen; Nikolay Grigorenko; Alex R Khomutov; Mervi T Hyvönen; Anne Uimari; Jouko Vepsäläinen; Riitta Sinervirta; Tuomo A Keinänen; Slavoljub Vujcic; Leena Alhonen; Carl W Porter; Juhani Jänne
Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.
The Journal of biological chemistry 2005;280(8):6595-601.
2005: Karl-Heinz Herzig; Juhani Jänne; Leena Alhonen
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
Scandinavian journal of gastroenterology 2005;40(1):120-1.
2004: Freya Vercauteren; Stefan Clerens; Line Roy; Nathalie Hamel; Lutgarde Arckens; Frans Vandesand; Leena Alhonen; Juhani Janne; Moshe Szyf; A Claudio Cuello
Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1.
Brain research. Molecular brain research 2004;132(2):241-59.
2004: Nikolay Grigorenko; Jouko Vepsalainen; A Jarvinen; Tuomo Keinanen; Leena Alhonen; Juhani Janne; A M Kritsyn; Alex R Khomutov
[A new synthesis of alpha-methylspermidine].
Bioorganicheskaia khimiia 2004;30(4):441-5.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; Leena Alhonen; Juhani Janne; Susan M Grant; Francisco Wandosell; Andres Muro; Francisco Baralle; Hongshan Li; karen duff; Moshe Szyf; A Claudio Cuello
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
Journal of Alzheimer's disease : JAD 2004;6(3):209-19.
2004: Selma K Kaasinen; Mari Oksman; Leena Alhonen; Heikki Tanila; Juhani Jänne
Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment.
Pharmacology, biochemistry, and behavior 2004;78(1):35-45.
2004: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen
Genetic approaches to the cellular functions of polyamines in mammals.
European journal of biochemistry / FEBS 2004;271(5):877-94.
2004: Rinnat M Porat; Myriam Grunewald; Anat Globerman; Ahuva Itin; Gregory Barshtein; Leena Alhonen; Kari Alitalo; Eli Keshet
Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies.
Circulation research 2004;94(3):394-401.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; E Dowd; J Jänne; Susan M Grant; Moshe Szyf; Francisco Wandosell; Jesús Avila; H Grimm; Stephen B Dunnett; Tobias Hartmann; Leena Alhonen; A Claudio Cuello
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.
Neuroscience 2004;129(3):583-92.
2003: Selma K Kaasinen; Olli H J Gröhn; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Experimental neurology 2003;183(2):645-52.
2003: T L Räsänen; Leena Alhonen; Riitta Sinervirta; Anne Uimari; K Kaasinen; Tuomo A Keinänen; Karl-Heinz Herzig; Juhani Jänne
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
Scandinavian journal of gastroenterology 2003;38(7):787-93.
2003: Tiina Wahlfors; Anne Karppinen; Leena Alhonen; Juhani Jänne; Jarmo Wahlfors
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
International journal of cancer. Journal international du cancer 2003;104(3):380-8.
2003: Päivi Heikkinen; Veli-Matti Kosma; Leena Alhonen; Hannele Huuskonen; Hannu Komulainen; Timo Heikki Kumlin; Jarmo T Laitinen; S Lang; Lauri Puranen; Jukka Juutilainen
Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice.
International journal of radiation biology 2003;79(4):221-33.
2002: Tiina-Liisa Rasanen; Leena Alhonen; Riitta Sinervirta; Tuomo Keinanen; Karl-Heinz Herzig; Suvikki Suppola; Alex R Khomutov; Jouko Vepsalainen; Juhani Janne
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
The Journal of biological chemistry 2002;277(42):39867-72.
2002: Giorgio Gimelli; Sabrina Giglio; Orsetta Zuffardi; Leena Alhonen; Suvikki Suppola; Roberto Cusano; Cristiana Lo Nigro; Rosanna Gatti; Roberto Ravazzolo; Marco Seri
Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD).
Human genetics 2002;111(3):235-41.
2002: Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
The Journal of biological chemistry 2002;277(28):25323-8.
2002: Selma K Kaasinen; Gundars Goldsteins; Leena Alhonen; Juhani Jänne; Jari Koistinaho
Induction and activation of protein kinase C delta in hippocampus and cortex after kainic acid treatment.
Experimental neurology 2002;176(1):203-12.
2002: Timo Heikki Kumlin; Päivi Heikkinen; Veli-Matti Kosma; Leena Alhonen; Juhani Jänne; Jukka Juutilainen
p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields.
Radiation and environmental biophysics 2002;41(2):155-8.
2002: Leena Alhonen; Tiina-Liisa Räsänen; Riitta Sinervirta; Jyrki Parkkinen; Veli-Pekka Korhonen; Marko Pietilä; Juhani Jänne
Polyamines are required for the initiation of rat liver regeneration.
The Biochemical journal 2002;362(Pt 1):149-53.
2002: Seok-Hong Min; Rosalia C M Simmen; Leena Alhonen; Maria Halmekyto; Carl W Porter; Juhani Janne; Frank A Simmen
Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT).
The Journal of biological chemistry 2002;277(5):3647-57.
2001: Suvikki Suppola; Sami Heikkinen; Jyrki Parkkinen; Mikko Uusi-Oukari; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.
The Biochemical journal 2001;358(Pt 2):343-8.
2001: Marko Pietilä; Jyrki Parkkinen; Leena Alhonen; Juhani Jänne
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
The Journal of investigative dermatology 2001;116(5):801-5.
2001: Veli-Pekka Korhonen; Kirsi Niiranen; Maria Halmekytö; Marko Pietilä; Paula Diegelman; Jyrki Parkkinen; T Eloranta; Carl W Porter; Leena Alhonen; Juhani Jänne
Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.
Molecular pharmacology 2001;59(2):231-8.
2000: Tommi Saarelainen; Raimo Pussinen; Eija Koponen; Leena Alhonen; Garry Wong; Jouni Sirviö; Eero Castrén
Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP.
Synapse (New York, N.Y.) 2000;38(1):102-4.
2000: Tommi Saarelainen; Jouko Lukkarinen; Susanna Koponen; Olli H J Gröhn; Jukka Jolkkonen; Eija Koponen; Annakaisa Haapasalo; Leena Alhonen; Garry Wong; Jari Koistinaho; Risto A Kauppinen; Eero Castrén
Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia.
Molecular and cellular neurosciences 2000;16(2):87-96.
2000: Leena Alhonen; Jyrki Parkkinen; Tuomo Keinanen; Riitta Sinervirta; Karl-Heinz Herzig; Juhani Jänne
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8290-5.
2000: K Kaasinen; Jari Koistinaho; Leena Alhonen; Juhani Jänne
Overexpression of spermidine/spermine N-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity.
The European journal of neuroscience 2000;12(2):540-8.
1999: Jouko Lukkarinen; Olli H J Gröhn; Leena Alhonen; Juhani Jänne; Risto A Kauppinen
Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
Brain research 1999;826(2):325-9.
1999: Leena Alhonen; Marko Pietilä; Maria Halmekytö; Debora L Kramer; Juhani Jänne; Carl W Porter
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
Molecular pharmacology 1999;55(4):693-8.
1999: Suvikki Suppola; Marko Pietilä; Jyrki Parkkinen; Veli-Pekka Korhonen; Leena Alhonen; Maria Halmekytö; Carl W Porter; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
The Biochemical journal 1999;338 ( Pt 2)():311-6.
1998: Jouko Lukkarinen; Risto A Kauppinen; Olli H J Gröhn; JM Oja; Riitta Sinervirta; Aki Järvinen; Leena Alhonen; Juhani Jänne
Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats.
The European journal of neuroscience 1998;10(6):2046-55.
1998: Raimo Pussinen; Jouni Sirviö; Leena Alhonen; John Larson; Maria Halmekytö; Esa H Koivisto; Juhani Jänne
Preserved induction of long-term potentiation in the stratum radiatum in the CA1 field of hippocampal slices from transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Synapse (New York, N.Y.) 1998;28(4):288-93.
1998: Leena Alhonen; Anne Karppinen; Mikko Uusi-Oukari; Slavoljub Vujcic; Veli-Pekka Korhonen; Maria Halmekytö; Debora L Kramer; R Hines; Juhani Jänne; Carl W Porter
Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1998;273(4):1964-9.
1998: Juhani Jänne; Leena Alhonen; Juha Hyttinen; T Peura; M Tolvanen; Veli-Pekka Korhonen
Transgenic bioreactors.
Biotechnology annual review 1998;4():55-74.
1998: Timo Heikki Kumlin; Leena Alhonen; Juhani Jänne; S Lang; Veli-Matti Kosma; Jukka Juutilainen
Epidermal ornithine decarboxylase and polyamines in mice exposed to 50 Hz magnetic fields and UV radiation.
Bioelectromagnetics 1998;19(6):388-91.
1998: Timo Heikki Kumlin; Veli-Matti Kosma; Leena Alhonen; Juhani Jänne; Hannu Komulainen; S Lang; Tapio Rytömaa; Kristina Servomaa; Jukka Juutilainen
Effects of 50 Hz magnetic fields on UV-induced skin tumourigenesis in ODC-transgenic and non-transgenic mice.
International journal of radiation biology 1998;73(1):113-21.
1997: Marko Pietilä; Leena Alhonen; Maria Halmekytö; P Kanter; Juhani Jänne; Carl W Porter
Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1997;272(30):18746-51.
1997: Ritva Heljasvaara; I Veress; Maria Halmekytö; Leena Alhonen; Juhani Jänne; P Laajala; Antti Pajunen
Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues.
The Biochemical journal 1997;323 ( Pt 2)():457-62.
1997: Veli-Pekka Korhonen; M Tolvanen; Juha Hyttinen; Mikko Uusi-Oukari; Riitta Sinervirta; Leena Alhonen; M Jauhiainen; Olli A Jänne; Juhani Jänne
Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits.
European journal of biochemistry / FEBS 1997;245(2):482-9.
1997: Mikko O Hiltunen; Leena Alhonen; J Koistinaho; S Myöhänen; Matti Pääkkönen; S Marin; Veli-Matti Kosma; Juhani Jänne
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.
International journal of cancer. Journal international du cancer 1997;70(6):644-8.
1997: Jouko Lukkarinen; Olli H J Gröhn; Riitta Sinervirta; Aki Järvinen; Risto A Kauppinen; Juhani Jänne; Leena Alhonen
Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion.
Stroke; a journal of cerebral circulation 1997;28(3):639-45.
1997: Mikko O Hiltunen; J Koistinaho; Leena Alhonen; S Myöhänen; S Marin; Veli-Matti Kosma; Matti Pääkkönen; Juhani Jänne
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer.
British journal of cancer 1997;76(9):1124-30.
1996: Mati Reeben; J Arbatova; J Palgi; Riitta Miettinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; PJ Riekkinen; Mart Saarma
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Journal of neuroscience research 1996;45(5):542-8.
1996: Leena Alhonen; Sami Heikkinen; Riitta Sinervirta; Maria Halmekytö; P Alakuijala; Juhani Jänne
Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter.
The Biochemical journal 1996;314 ( Pt 2)():405-8.
1995: Risto A Kauppinen; Leena Alhonen
Transgenic animals as models in the study of the neurobiological role of polyamines.
Progress in neurobiology 1995;47(6):545-63.
1995: Leena Alhonen; Maria Halmekytö; Veli-Matti Kosma; Jarmo Wahlfors; Risto A Kauppinen; Juhani Jänne
Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration.
International journal of cancer. Journal international du cancer 1995;63(3):402-4.
1995: Veli-Pekka Korhonen; Maria Halmekytö; L Kauppinen; S Myöhänen; Jarmo Wahlfors; T Keinänen; T Hyvönen; Leena Alhonen; T Eloranta; Juhani Jänne
Molecular cloning of a cDNA encoding human spermine synthase.
DNA and cell biology 1995;14(10):841-7.
1995: J Korhonen; I Lahtinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; Daniel J Dumont; Kari Alitalo
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1995: Jarmo Wahlfors; S Myöhänen; Veli-Pekka Korhonen; Leena Alhonen; Juhani Jänne
Long-term reduction of amplified ornithine decarboxylase sequences in human myeloma cells.
The Biochemical journal 1995;310 ( Pt 1)():299-303.
1994: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö
Transgenic bioreactors.
The International journal of biochemistry 1994;26(7):859-70.
1994: Juha Hyttinen; T Peura; M Tolvanen; J Aalto; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö; S Myöhänen; Juhani Jänne
Generation of transgenic dairy cattle from transgene-analyzed and sexed embryos produced in vitro.
Bio/technology (Nature Publishing Company) 1994;12(6):606-8.
1994: S Myöhänen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Nucleotide sequence of mouse spermidine synthase cDNA.
DNA sequence : the journal of DNA sequencing and mapping 1994;4(5):343-6.
1993: H Hakovirta; A Keiski; Jorma Toppari; Maria Halmekytö; Leena Alhonen; J Jänne; Martti Parvinen
Polyamines and regulation of spermatogenesis: selective stimulation of late spermatogonia in transgenic mice overexpressing the human ornithine decarboxylase gene.
Molecular endocrinology (Baltimore, Md.) 1993;7(11):1430-6.
1993: Toivo Halonen; Juhani Sivenius; Riitta Miettinen; Maria Halmekytö; Risto A Kauppinen; Riitta Sinervirta; L Alakuijala; Leena Alhonen; E MacDonald; Juhani Jänne
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
The European journal of neuroscience 1993;5(9):1233-9.
1993: L Kauppinen; S Myöhänen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Transgenic mice over-expressing the human spermidine synthase gene.
The Biochemical journal 1993;293 ( Pt 2)():513-6.
1993: Maria Halmekytö; Juha Hyttinen; Riitta Sinervirta; Pia Leppänen; Juhani Jänne; Leena Alhonen
Regulation of the expression of human ornithine decarboxylase gene and ornithine decarboxylase promoter-driven reporter gene in transgenic mice.
The Biochemical journal 1993;292 ( Pt 3)():927-32.
1993: Mati Reeben; Maria Halmekytö; Leena Alhonen; Riitta Sinervirta; Mart Saarma; Juhani Jänne
Tissue-specific expression of rat light neurofilament promoter-driven reporter gene in transgenic mice.
Biochemical and biophysical research communications 1993;192(2):465-70.
1993: Maria Halmekytö; Leena Alhonen; L Alakuijala; Juhani Jänne
Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines.
The Biochemical journal 1993;291 ( Pt 2)():505-8.
1993: Robert Winqvist; Leena Alhonen; K H Grzeschik; J Jänne; T O Eloranta
Mapping of the human spermidine synthase gene (SRM) to 1p36 and a probable pseudogene (SRML2) to region 3p14-->q21.
Cytogenetics and cell genetics 1993;64(1):64-8.
1993: Helmut Mett; J Stanek; J A Lopez-Ballester; Juhani Jänne; Leena Alhonen; Riitta Sinervirta; Joerg Frei; U Regenass
Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues.
Cancer chemotherapy and pharmacology 1993;32(1):39-45.
1992: Jarmo Wahlfors; H Hiltunen; Kirsti Heinonen; Esa Hämäläinen; Leena Alhonen; Juhani Jänne
Genomic hypomethylation in human chronic lymphocytic leukemia.
Blood 1992;80(8):2074-80.
1992: Maria Halmekytö; Kari Syrjänen; Juhani Jänne; Leena Alhonen
Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene.
Biochemical and biophysical research communications 1992;187(1):493-7.
1992: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Maria Halmekytö
Transgenic animals as bioproducers of therapeutic proteins.
Annals of medicine 1992;24(4):273-80.
1992: Risto A Kauppinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Nuclear magnetic resonance spectroscopy study on energy metabolism, intracellular pH, and free Mg2+ concentration in the brain of transgenic mice overexpressing human ornithine decarboxylase gene.
Journal of neurochemistry 1992;58(3):831-6.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; Olli A Jänne; Juhani Jänne
Position-independent, aberrant expression of the human ornithine decarboxylase gene in transgenic mice.
Biochemical and biophysical research communications 1991;180(1):262-7.
1991: Maria Halmekytö; Juha Hyttinen; Riitta Sinervirta; M Utriainen; S Myöhänen; H M Voipio; Jarmo Wahlfors; S Syrjänen; Kari Syrjänen; Leena Alhonen
Transgenic mice aberrantly expressing human ornithine decarboxylase gene.
The Journal of biological chemistry 1991;266(29):19746-51.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; T Eloranta; Juhani Jänne
Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene.
The Biochemical journal 1991;278 ( Pt 3)():895-8.
1991: I M Hyttinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Levels of ornithine decarboxylase genomic sequences, heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine.
The Biochemical journal 1991;278 ( Pt 3)():871-4.
1991: Juhani Jänne; Leena Alhonen; P Leinonen
Polyamines: from molecular biology to clinical applications.
Annals of medicine 1991;23(3):241-59.
1991: S Myöhänen; L Kauppinen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Human spermidine synthase gene: structure and chromosomal localization.
DNA and cell biology 1991;10(6):467-74.
1991: M Kolmer; T Ord; Leena Alhonen; Juha Hyttinen; Mart Saarma; R Villems; Juhani Jänne
Assignment of human prochymosin pseudogene to chromosome 1.
Genomics 1991;10(2):496-8.
1990: Noreen J Hickok; Jarmo Wahlfors; A Crozat; Maria Halmekytö; Leena Alhonen; J Jänne; Olli A Jänne
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.
Gene 1990;93(2):257-63.
1990: Jarmo Wahlfors; Leena Alhonen; L Kauppinen; T Hyvönen; Juhani Jänne; T O Eloranta
Human spermidine synthase: cloning and primary structure.
DNA and cell biology 1990;9(2):103-10.
1989: Erkki Hölttä; A Hirvonen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne; A Kallio
Human ornithine decarboxylase(ODC)-encoding gene: cloning and expression in ODC-deficient CHO cells.
Gene 1989;83(1):125-35.
1989: Maria Halmekytö; A Hirvonen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Methylation of human ornithine decarboxylase gene before transfection abolishes its transient expression in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1989;162(1):528-34.
1989: A Hirvonen; T Eloranta; T Hyvönen; Leena Alhonen; Juhani Jänne
Characterization of difluoromethylornithine-resistant mouse and human tumour cell lines.
The Biochemical journal 1989;258(3):709-13.
1989: Juhani Jänne; Leena Alhonen; A Hirvonen; Jarmo Wahlfors
Molecular genetics of ornithine decarboxylase in human tumor cells.
Advances in enzyme regulation 1989;28():81-91.
1988: V Lipsanen; P Leinonen; Leena Alhonen; Juhani Jänne
Hypomethylation of ornithine decarboxylase gene and erb-A1 oncogene in human chronic lymphatic leukemia.
Blood 1988;72(6):2042-4.
1988: K Polvinen; Riitta Sinervirta; Leena Alhonen; Juhani Jänne
Overproduction of ornithine decarboxylase confers an apparent growth advantage to mouse tumor cells.
Biochemical and biophysical research communications 1988;155(1):373-8.
1988: T Eloranta; O Kajander; L Kauppinen; T Hyvönen; Annikka Linnala-Kankkunen; N Kalkkinen; M Kulomaa; Leena Alhonen; Juhani Jänne
Approaching the structures of mammalian propylamine transferases and their genes.
Advances in experimental medicine and biology 1988;250():117-26.
1988: Juhani Jänne; Leena Alhonen; A Hirvonen; Jarmo Wahlfors; Riitta Sinervirta; T Eloranta; Erkki Hölttä; A Kallio
Structure, amplification and methylation of ornithine decarboxylase genes in human malignant cells.
Advances in experimental medicine and biology 1988;250():253-60.