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Oana Ciofu

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TOP 3
Oana Ciofu; Christine R Hansen; Niels Høiby
Respiratory bacterial infections in cystic fibrosis.
Wang Hengzhuang; Oana Ciofu; Antonio Oliver; Zhijun Song; Hong Wu; Liang Yang; Niels Høiby
High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms.
Anders Folkesson; Niels Høiby; Lars Jelsbak; Helle Krogh Johansen; Oana Ciofu; Lei Yang; Søren Molin
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective.

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All Publications

2013: Oana Ciofu; Christine R Hansen; Niels Høiby
Respiratory bacterial infections in cystic fibrosis.
Current opinion in pulmonary medicine 2013;19(3):251-8.
2013: Wang Hengzhuang; Oana Ciofu; Antonio Oliver; Zhijun Song; Hong Wu; Liang Yang; Niels Høiby
High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2013;57(1):196-204.
2012: Anders Folkesson; Niels Høiby; Lars Jelsbak; Helle Krogh Johansen; Oana Ciofu; Lei Yang; Søren Molin
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective.
Nature reviews. Microbiology 2012;10(12):841-51.
2012: Oana Ciofu; Lotte F Mandsberg; Hengzhuang Wang; Niels Høiby
Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections.
FEMS immunology and medical microbiology 2012;65(2):215-25.
2012: Wang Hengzhuang; Zhijun Song; Hong Wu; Oana Ciofu; Niels Høiby
In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection.
Antimicrobial agents and chemotherapy 2012;56(5):2683-90.
2012: Robert Sautter; Lisa Schneper; Tina Wassermann; Søren Molin; Dennis E Ohman; Damaris Ramos; Oana Ciofu; Caroline A Devries; Morten Hentzer; Arne Heydorn; Niels Høiby; Arsalan Kharazmi; Chong-Lek Koh; Kalai Mathee
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.
Gene 2012;498(2):242-53.
2012: Peter Østrup Jensen; Jens Lykkesfeldt; Thomas Bjarnsholt; Niels Høiby; Hans Petter Hougen; Oana Ciofu
Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigs.
Basic & clinical pharmacology & toxicology 2012;110(4):353-8.
2011: Lotte Frigaard Mandsberg; Antonio Oliver; Niels Høiby; Nikolai Kirkby; Maria D Maciá; Morten Alhede; Kirsten R Bergmann; Lasse E Christiansen; Oana Ciofu
Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).
FEMS microbiology letters 2011;324(1):28-37.
2011: Wang Hengzhuang; Zhijun Song; Hong Wu; Oana Ciofu; Niels Høiby
Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2011;55(9):4469-74.
2011: Lei Yang; Lars Jelsbak; Rasmus Lykke Marvig; Søren Damkiær; Christopher T Workman; Martin Holm Rau; Susse Kirkelund Hansen; Anders Folkesson; Helle Krogh Johansen; Oana Ciofu; Niels Høiby; Morten O A Sommer; Søren Molin
Evolutionary dynamics of bacteria in a human host environment.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7481-6.
2011: Baoleri Lee; Charlotte K Schjerling; Nikolai Kirkby; Nadine Hoffmann; Rehannah Borup; Søren Molin; Niels Høiby; Oana Ciofu
Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2011;119(4-5):263-74.
2011: Niels Høiby; Peter Østrup Jensen; Helle Krogh Johansen; Søren Molin; Claus Moser; Zhi-jun Song; Tim Tolker-Nielsen; Oana Ciofu; Michael Givskov; Thomas Bjarnsholt
The clinical impact of bacterial biofilms.
International journal of oral science 2011;3(2):55-65.
2010: Niels Høiby; Oana Ciofu; Thomas Bjarnsholt
Pseudomonas aeruginosa biofilms in cystic fibrosis.
Future microbiology 2010;5(11):1663-74.
2010: Niels Høiby; Thomas Bjarnsholt; Michael Givskov; Søren Molin; Oana Ciofu
Antibiotic resistance of bacterial biofilms.
International journal of antimicrobial agents 2010;35(4):322-32.
2010: Oana Ciofu; Lotte F Mandsberg; Thomas Bjarnsholt; Tina Wassermann; Niels Høiby
Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants.
Microbiology (Reading, England) 2010;156(Pt 4):1108-19.
2010: Thomas Bjarnsholt; Peter Østrup Jensen; Tim Holm Jakobsen; Richard Phipps; Anne Kirstine Nielsen; Morten Theil Rybtke; Tim Tolker-Nielsen; Michael Givskov; Niels Høiby; Oana Ciofu
Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.
PloS one 2010;5(4):e10115.
2010: M Kolpen; C R Hansen; Thomas Bjarnsholt; Claus Moser; Lisa D Christensen; M van Gennip; Oana Ciofu; L Mandsberg; Arsalan Kharazmi; Gerd Döring; Michael Givskov; Niels Høiby; Peter Østrup Jensen
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis.
Thorax 2010;65(1):57-62.
2009: Maria van Gennip; Claus Moser; Louise D Christensen; Thomas Bjarnsholt; Henrik Calum; Peter Østrup Jensen; Lars Christophersen; Hans Petter Hougen; Oana Ciofu; Søren Molin; Michael Givskov; Niels Høiby
Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2009;64(6):1241-50.
2009: L F Mandsberg; Oana Ciofu; Nikolai Kirkby; L E Christiansen; Henrik E Poulsen; Niels Høiby
Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.
Antimicrobial agents and chemotherapy 2009;53(6):2483-91.
2008: K R Philipsen; L E Christiansen; L F Mandsberg; Oana Ciofu; Henrik Madsen
Maximum Likelihood based comparison of the specific growth rates for P. aeruginosa and four mutator strains.
Journal of microbiological methods 2008;75(3):551-7.
2008: Helle Krogh Johansen; Samuel M Moskowitz; Oana Ciofu; Tacjana Pressler; Niels Høiby
Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2008;7(5):391-7.
2008: Oana Ciofu; Baoleri Lee; Marie Johannesson; Nils Olav Hermansen; Peter Meyer; Niels Høiby
Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants.
Microbiology (Reading, England) 2008;154(Pt 1):103-13.
2007: Niels Høiby; Helle Krogh Johansen; Oana Ciofu; Peter Østrup Jensen; Thomas Bjarnsholt; Michael Givskov
[Foreign body infections--biofilms and quorum sensing].
Ugeskrift for laeger 2007;169(48):4163-6.
2007: Lars Jelsbak; Helle Krogh Johansen; Anne-Louise Frost; Regitze Thøgersen; Line E Thomsen; Oana Ciofu; Lei Yang; Janus A J Haagensen; Niels Høiby; Søren Molin
Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients.
Infection and immunity 2007;75(5):2214-24.
2005: Baoleri Lee; Janus A J Haagensen; Oana Ciofu; Jens Bo Andersen; Niels Høiby; Søren Molin
Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Journal of clinical microbiology 2005;43(10):5247-55.
2005: Oana Ciofu; Bente Riis; Tacjana Pressler; Henrik E Poulsen; Niels Høiby
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.
Antimicrobial agents and chemotherapy 2005;49(6):2276-82.
2005: Anne Malfroot; Georgios Adam; Oana Ciofu; Gerd Döring; Christiane Knoop; Aloïs B Lang; Pierre Van Damme; Isidoor Dab; Andrew Bush
Immunisation in the current management of cystic fibrosis patients.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2005;4(2):77-87.
2005: Nadine Hoffmann; Thomas Bovbjerg Rasmussen; Peter Østrup Jensen; Charlotte Stub; Morten Hentzer; Søren Molin; Oana Ciofu; Michael Givskov; Helle Krogh Johansen; Niels Høiby
Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.
Infection and immunity 2005;73(4):2504-14.
2004: Niels Bagge; Martin Schuster; Morten Hentzer; Oana Ciofu; Michael Givskov; Everett Peter Greenberg; Niels Høiby
Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Antimicrobial agents and chemotherapy 2004;48(4):1175-87.
2004: Niels Bagge; Morten Hentzer; Jens Bo Andersen; Oana Ciofu; Michael Givskov; Niels Høiby
Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2004;48(4):1168-74.
2003: Zhijun Song; Hong Wu; Oana Ciofu; Kok-Fai Kong; Niels Høiby; Jørgen Rygaard; Arsalan Kharazmi; Kalai Mathee
Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection.
Journal of medical microbiology 2003;52(Pt 9):731-40.
2003: Oana Ciofu
Pseudomonas aeruginosa chromosomal beta-lactamase in patients with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response.
APMIS. Supplementum 2003;(116):1-47.
2002: Oana Ciofu; Niels Bagge; Niels Høiby
Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(12):881-91.
2002: Niels Bagge; Oana Ciofu; Morten Hentzer; Joan I A Campbell; Michael Givskov; Niels Høiby
Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
Antimicrobial agents and chemotherapy 2002;46(11):3406-11.
2001: Oana Ciofu; V Fussing; Niels Bagge; C Koch; Niels Høiby
Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and RiboPrinting.
The Journal of antimicrobial chemotherapy 2001;48(3):391-6.
2001: Niels Høiby; H Krogh Johansen; C Moser; Z Song; Oana Ciofu; A Kharazmi
Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.
Microbes and infection / Institut Pasteur 2001;3(1):23-35.
2000: Niels Bagge; Oana Ciofu; L T Skovgaard; Niels Høiby
Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal beta-lactamase.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2000;108(9):589-600.
2000: Oana Ciofu; Terry J Beveridge; JL Kadurugamuwa; J Walther-Rasmussen; Niels Høiby
Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2000;45(1):9-13.
1999: Kalai Mathee; Oana Ciofu; Claus Sternberg; PW Lindum; Joan I A Campbell; P Jensen; A H Johnsen; Michael Givskov; Dennis Ohman; Søren Molin; Niels Høiby; Arsalan Kharazmi
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.
Microbiology (Reading, England) 1999;145 ( Pt 6)():1349-57.
1999: Oana Ciofu; T D Petersen; P Jensen; Niels Høiby
Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.
Thorax 1999;54(2):141-4.
1997: Marina Ulanova; T D Petersen; Oana Ciofu; P Jensen; Mirjana Hahn-Zoric; Lars A Hanson; Niels Høiby
The clonal antibody response to Pseudomonas aeruginosa heat shock protein is highly diverse in cystic fibrosis patients.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(6):449-56.
1997: Joan I A Campbell; Oana Ciofu; Niels Høiby
Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.
Antimicrobial agents and chemotherapy 1997;41(6):1380-4.
1997: Oana Ciofu; Tacjana Pressler; Janardan P Pandey; Niels Høiby
The influence of allotypes on the IgG subclass response to chromosomal beta-lactamase of Pseudomonas aeruginosa in cystic fibrosis patients.
Clinical and experimental immunology 1997;108(1):88-94.
1996: Niels Høiby; Oana Ciofu; T Jensen; Tacjana Pressler; Helle Krogh Johansen; C Koch
Use of carbapenems and other antibiotics for pulmonary infections in patients with cystic fibrosis.
The Pediatric infectious disease journal 1996;15(8):738-43.
1996: T D Petersen; Oana Ciofu; Tacjana Pressler; B Giwercman; S S Pedersen; Niels Høiby
Quantitative analysis of the IgG and IgG subclass immune responses to chromosomal Pseudomonas aeruginosa beta-lactamase in serum from patients with cystic fibrosis by western blotting and laser scanning densitometry.
Thorax 1996;51(7):733-8.
1995: Oana Ciofu; B Giwercman; J Walter-Rasmussen; Tacjana Pressler; S S Pedersen; Niels Høiby
Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams.
The Journal of antimicrobial chemotherapy 1995;35(2):295-304.
1994: Oana Ciofu; B Giwercman; S S Pedersen; Niels Høiby
Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1994;102(9):674-80.