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Martin Citron

Research Profile

Chemicals & Drugs

Disorders

Alzheimer's Disease

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Living Beings

Physiology

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Molecular Sequence Data

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Publications

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Stephen Wood; Jianhua Zhang; Wenge Zhong; Li Zhu; Safura Babu-Khan; Kui Chen; Martin Citron; Thomas A Dineen; Joel Esmay; Dean Hickman; Stephen A Hitchcock; Matthew R Kaller; Y Luo; Roger Pham; Matthew M Weiss; Paul H Wen; Toni Williamson
Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors.
Xiyun Chai; Nicola Buckner; Claire V Cella; Peter Davies; Jenna Hanmer; Michael Hutton; Robert Kinley; Tracey K Murray; Michael J O'Neill; Helen Sims; Su Wu; Martin Citron
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
Martin Citron
Alzheimer's disease: strategies for disease modification.

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All Publications

2012: Stephen Wood; Jianhua Zhang; Wenge Zhong; Li Zhu; Safura Babu-Khan; Kui Chen; Martin Citron; Thomas A Dineen; Joel Esmay; Dean Hickman; Stephen A Hitchcock; Matthew R Kaller; Y Luo; Roger Pham; Matthew M Weiss; Paul H Wen; Toni Williamson
Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors.
The Journal of pharmacology and experimental therapeutics 2012;343(2):460-7.
2011: Xiyun Chai; Nicola Buckner; Claire V Cella; Peter Davies; Jenna Hanmer; Michael Hutton; Robert Kinley; Tracey K Murray; Michael J O'Neill; Helen Sims; Su Wu; Martin Citron
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
The Journal of biological chemistry 2011;286(39):34457-67.
2010: Martin Citron
Alzheimer's disease: strategies for disease modification.
Nature reviews. Drug discovery 2010;9(5):387-98.
2010: Carlo Sala Frigerio; Julia V Fadeeva; Aedín M Minogue; Martin Citron; Fred Van Leuven; Matthias Staufenbiel; Paolo Paganetti; Dennis J Selkoe; Dominic M Walsh
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
The FEBS journal 2010;277(6):1503-18.
2007: Huifang Ma; Sylvain Lesné; Linda Kotilinek; Jill V Steidl-Nichols; Mathew Sherman; Linda Younkin; Steven G Younkin; Colleen Forster; Nicolas Sergeant; André Delacourte; Robert Vassar; Martin Citron; Paulo Kofuji; Linda M Boland; Karen K. Hsiao Ashe
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8167-72.
2007: Jie Zhao; Yifan Fu; Marina Yasvoina; Peizhen Shao; Brian Hitt; Tracy O'Connor; Sreemathi Logan; Erika Maus; Martin Citron; Robert Berry; Lester Binder; Robert Vassar
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3639-49.
2007: MASUO OHNO; Sarah L Cole; Marina Yasvoina; Jie Zhao; Martin Citron; Robert Berry; John F Disterhoft; Robert Vassar
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Neurobiology of disease 2007;26(1):134-45.
2006: Michael Willem; Alistair Garratt; Bozidar Novak; Martin Citron; Steve Kaufmann; Andrea Rittger; Bart DeStrooper; Paul Saftig; Carmen Birchmeier; Christian Haass
Control of peripheral nerve myelination by the beta-secretase BACE1.
Science (New York, N.Y.) 2006;314(5799):664-6.
2006: MASUO OHNO; Lei Chang; Wilbur Tseng; Holly Oakley; Martin Citron; William L Klein; Robert Vassar; John F Disterhoft
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
The European journal of neuroscience 2006;23(1):251-60.
2005: Shinobu Kitazume; Kazuhiro Nakagawa; Ritsuko Oka; Yuriko Tachida; Kazuko Ogawa; Yi Luo; Martin Citron; Hiroshi Shitara; Choji Taya; Hiromichi Yonekawa; James C Paulson; Eiji Miyoshi; Naoyuki Taniguchi; Yasuhiro Hashimoto
In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
The Journal of biological chemistry 2005;280(9):8589-95.
2004: Martin Citron
Strategies for disease modification in Alzheimer's disease.
Nature reviews. Neuroscience 2004;5(9):677-85.
2004: Rena Li; Kristina Lindholm; Li-Bang Yang; Xu Yue; Martin Citron; Riqiang Yan; Thomas Beach; Lucia I Sue; Marwan Sabbagh; Huaibin Cai; Philip C Wong; Donald L Price; Yong Shen
Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3632-7.
2004: Martin Citron
Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge.
Trends in pharmacological sciences 2004;25(2):92-7.
2004: MASUO OHNO; Evgeny A Sametsky; Linda Younkin; Holly Oakley; Steven G Younkin; Martin Citron; Robert Vassar; John F Disterhoft
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Neuron 2004;41(1):27-33.
2003: Yi Luo; Brad Bolon; Michael A Damore; Dan Fitzpatrick; Hantao Liu; Jianhua Zhang; Qiao Yan; Robert Vassar; Martin Citron
BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time.
Neurobiology of disease 2003;14(1):81-8.
2003: Qiao Yan; Jianhua Zhang; Hantao Liu; Safura Babu-Khan; Robert Vassar; Anja Leona Biere; Martin Citron; Gary Landreth
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(20):7504-9.
2003: Sampathkumar Krishnan; Eva Y Chi; Stephen J Wood; Brent S Kendrick; Cynthia Li; William Garzon-Rodriguez; Jette Wypych; Theodore W Randolph; Linda O Narhi; Anja Leona Biere; Martin Citron; John F Carpenter
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Biochemistry 2003;42(3):829-37.
2003: Li-Bang Yang; Kristina Lindholm; Riqiang Yan; Martin Citron; Weiming Xia; Xiao-Li Yang; Thomas Beach; Lucia I Sue; Philip C Wong; Donald L Price; Rena Li; Yong Shen
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Nature medicine 2003;9(1):3-4.
2002: Martin Citron
Emerging Alzheimer's disease therapies: inhibition of beta-secretase.
Neurobiology of aging 2002;23(6):1017-22.
2002: Martin Citron
Alzheimer's disease: treatments in discovery and development.
Nature neuroscience 2002;5 Suppl():1055-7.
2002: Martin Citron
Beta-secretase as a target for the treatment of Alzheimer's disease.
Journal of neuroscience research 2002;70(3):373-9.
2002: Banghua Sun; Wei Fan; Aldona Balciunas; Jillian K Cooper; Huiyuan Li; Shirley Steavenson; Paul E Denis; Yunjen Young; Beverly Adler; Larry Daugherty; Raffi Manoukian; Gary Elliott; Wenyan Shen; Jane Talvenheimo; David B Teplow; Mitsuru Haniu; Raj Haldankar; Jette Wypych; Christopher A Ross; Martin Citron; William G Richards
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Neurobiology of disease 2002;11(1):111-22.
2001: Y Luo; Brad Bolon; S Kahn; BD Bennett; Safura Babu-Khan; Paul E Denis; W Fan; H Kha; J Zhang; Y Gong; L Martin; Jean-Claude Louis; Q Yan; William G Richards; Martin Citron; Robert Vassar
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Nature neuroscience 2001;4(3):231-2.
2000: BD Bennett; Paul E Denis; Mitsuru Haniu; David B Teplow; S Kahn; Jean-Claude Louis; Martin Citron; Robert Vassar
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.
The Journal of biological chemistry 2000;275(48):37712-7.
2000: Anja Leona Biere; Stephen J Wood; Jette Wypych; Shirley Steavenson; Y Jiang; D Anafi; F W Jacobsen; Mark Jarosinski; GM Wu; Jean-Claude Louis; F Martin; Linda O Narhi; Martin Citron
Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs.
The Journal of biological chemistry 2000;275(44):34574-9.
2000: Martin Citron
Secretases as targets for the treatment of Alzheimer's disease.
Molecular medicine today 2000;6(10):392-7.
2000: Robert Vassar; Martin Citron
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
Neuron 2000;27(3):419-22.
2000: Mitsuru Haniu; Paul E Denis; Yunjen Young; E A Mendiaz; J Fuller; JO Hui; BD Bennett; S Kahn; S Ross; TL Burgess; V Katta; Gary A Rogers; Robert Vassar; Martin Citron
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.
The Journal of biological chemistry 2000;275(28):21099-106.
2000: BD Bennett; Safura Babu-Khan; R Loeloff; Jean-Claude Louis; E Curran; Martin Citron; Robert Vassar
Expression analysis of BACE2 in brain and peripheral tissues.
The Journal of biological chemistry 2000;275(27):20647-51.
2000: G M Rishton; D M Retz; P A Tempest; J Novotny; S Kahn; James J S Treanor; Jack Lile; Martin Citron
Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.
Journal of medicinal chemistry 2000;43(12):2297-9.
2000: Martin Citron
β-Secretase : Tissue Culture Studies of Sequence Specificity, Inhibitors, and Candidate Enzymes.
Methods in molecular medicine 2000;32():229-38.
2000: Martin Citron
Identifying proteases that cleave APP.
Annals of the New York Academy of Sciences 2000;920():192-6.
1999: Harald Steiner; H Romig; B Pesold; U Philipp; Miriam Baader; Martin Citron; Hansruedi Loetscher; Helmut Jacobsen; Christian Haass
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
Biochemistry 1999;38(44):14600-5.
1999: Robert Vassar; BD Bennett; Safura Babu-Khan; S Kahn; E A Mendiaz; Paul E Denis; David B Teplow; S Ross; P Amarante; R Loeloff; Y Luo; S Fisher; J Fuller; S Edenson; Jack Lile; Mark Jarosinski; Anja Leona Biere; E Curran; TL Burgess; Jean-Claude Louis; F Collins; James J S Treanor; G Rogers; Martin Citron
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Science (New York, N.Y.) 1999;286(5440):735-41.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: Stephen J Wood; Jette Wypych; Shirley Steavenson; Jean-Claude Louis; Martin Citron; Anja Leona Biere
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.
The Journal of biological chemistry 1999;274(28):19509-12.
1999: Linda O Narhi; Stephen J Wood; Shirley Steavenson; Y Jiang; GM Wu; D Anafi; S A Kaufman; F Martin; K Sitney; Paul E Denis; Jean-Claude Louis; Jette Wypych; Anja Leona Biere; Martin Citron
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation.
The Journal of biological chemistry 1999;274(14):9843-6.
1999: Harald Steiner; H Romig; MG Grim; U Philipp; B Pesold; Martin Citron; Ralf Baumeister; Christian Haass
The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing.
The Journal of biological chemistry 1999;274(12):7615-8.
1998: Harald Steiner; Anja Capell; B Pesold; Martin Citron; P M Kloetzel; Dennis J Selkoe; H Romig; Klaus Mendla; Christian Haass
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
The Journal of biological chemistry 1998;273(48):32322-31.
1998: Martin Citron; Christopher B Eckman; Thekla S Diehl; C Corcoran; Beth L Ostaszewski; Weiming Xia; Georges Levesque; Peter St George-Hyslop; Steven G Younkin; Dennis J Selkoe
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: S L Ross; F Martin; L Simonet; F Jacobsen; R Deshpande; Robert Vassar; B Bennett; Y Luo; S Wooden; S Hu; Martin Citron; TL Burgess
Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells.
The Journal of biological chemistry 1998;273(25):15309-12.
1998: Anja Capell; J Grünberg; B Pesold; A Diehlmann; Martin Citron; Ralph A. Nixon; Konrad Beyreuther; Dennis J Selkoe; Christian Haass
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Michael S Wolfe; Martin Citron; Thekla S Diehl; Weiming Xia; Isaac O Donkor; Dennis J Selkoe
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Journal of medicinal chemistry 1998;41(1):6-9.
1997: Jochen Walter; J Grünberg; Anja Capell; B Pesold; A Schindzielorz; Martin Citron; Klaus Mendla; Peter St George-Hyslop; Gerd Multhaup; Dennis J Selkoe; Christian Haass
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: Weiming Xia; Jimin Zhang; Dora Kholodenko; Martin Citron; Marcia B Podlisny; David B Teplow; Christian Haass; Peter Seubert; Edward H Koo; Dennis J Selkoe
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
The Journal of biological chemistry 1997;272(12):7977-82.
1997: Marcia B Podlisny; Martin Citron; P Amarante; R Sherrington; Weiming Xia; Jimin Zhang; Thekla S Diehl; Georges Levesque; Paul E Fraser; Christian Haass; Edward H Koo; Peter Seubert; Peter St George-Hyslop; David B Teplow; Dennis J Selkoe
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1997: Martin Citron; David Westaway; Weiming Xia; G Carlson; Thekla S Diehl; Georges Levesque; Kelly Johnson-Wood; Mike Lee; Peter Seubert; A Davis; Dora Kholodenko; Ruth Motter; R Sherrington; B Perry; H Yao; R Strome; I Lieberburg; Johanna M Rommens; S Kim; Dale Schenk; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Nature medicine 1997;3(1):67-72.
1996: Martin Citron; Thekla S Diehl; G Gordon; Anja Leona Biere; Peter Seubert; Dennis J Selkoe
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13170-5.
1996: Donalyn Scheuner; Christopher B Eckman; M Jensen; X Song; Martin Citron; N Suzuki; Thomas D Bird; John Hardy; Michael Hutton; Walter A Kukull; Eric B Larson; Ephrat Levy-Lahad; Matti Viitanen; Elaine Peskind; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; Rudolph E Tanzi; Wilma Wasco; Lars Lannfelt; Dennis J Selkoe; Steven G Younkin
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Martin Citron; Thekla S Diehl; Anja Capell; Christian Haass; David B Teplow; Dennis J Selkoe
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Neuron 1996;17(1):171-9.
1996: Dennis J Selkoe; T Yamazaki; Martin Citron; Marcia B Podlisny; Edward H Koo; David B Teplow; Christian Haass
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.
Annals of the New York Academy of Sciences 1996;777():57-64.
1995: Christian Haass; Cynthia A Lemere; Anja Capell; Martin Citron; Peter Seubert; Dale Schenk; Lars Lannfelt; Dennis J Selkoe
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine 1995;1(12):1291-6.
1995: Christian Haass; Anja Capell; Martin Citron; David B Teplow; Dennis J Selkoe
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(11):6186-92.
1995: C Haas; A Y Hung; Martin Citron; David B Teplow; Dennis J Selkoe
beta-Amyloid, protein processing and Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):398-402.
1995: Martin Citron; David B Teplow; Dennis J Selkoe
Generation of amyloid beta protein from its precursor is sequence specific.
Neuron 1995;14(3):661-70.
1994: Martin Citron; C Vigo-Pelfrey; David B Teplow; C Miller; Dale Schenk; J Johnston; Bengt Winblad; N Venizelos; Lars Lannfelt; Dennis J Selkoe
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11993-7.
1993: A Y Hung; Christian Haass; Roger M Nitsch; Wei Qiao Qiu; Martin Citron; Richard Jay Wurtman; John H Growdon; Dennis J Selkoe
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
The Journal of biological chemistry 1993;268(31):22959-62.
1993: Martin Citron; Christian Haass; Dennis J Selkoe
Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Neurobiology of aging 1993;14(6):571-3.
1992: Martin Citron; Tilman Oltersdorf; Christian Haass; Lisa McConlogue; A Y Hung; Peter Seubert; C Vigo-Pelfrey; I Lieberburg; Dennis J Selkoe
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature 1992;360(6405):672-4.
1992: Anja Leona Biere; Martin Citron; H Schuster
Transcriptional control via translational repression by c4 antisense RNA of bacteriophages P1 and P7.
Genes & development 1992;6(12A):2409-16.