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Ian Clark-Lewis

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Chemicals & Drugs

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Adrian Liston; Rachel E Kohler; Scott Townley; Sarah Haylock-Jacobs; Iain Comerford; Adriana C Caon; Julie Webster; Jodie M Harrison; Jeremy Swann; Ian Clark-Lewis; Heinrich Korner; Shaun R McColl
Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response.
Rachel E Kohler; Iain Comerford; Scott Townley; Sarah Haylock-Jacobs; Ian Clark-Lewis; Shaun R McColl
Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis.
Krishna Rajarathnam; Gregory N Prado; Harshica Fernando; Ian Clark-Lewis; Javier Navarro
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap.

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2009: Adrian Liston; Rachel E Kohler; Scott Townley; Sarah Haylock-Jacobs; Iain Comerford; Adriana C Caon; Julie Webster; Jodie M Harrison; Jeremy Swann; Ian Clark-Lewis; Heinrich Korner; Shaun R McColl
Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3121-30.
2008: Rachel E Kohler; Iain Comerford; Scott Townley; Sarah Haylock-Jacobs; Ian Clark-Lewis; Shaun R McColl
Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis.
Brain pathology (Zurich, Switzerland) 2008;18(4):504-16.
2006: Krishna Rajarathnam; Gregory N Prado; Harshica Fernando; Ian Clark-Lewis; Javier Navarro
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap.
Biochemistry 2006;45(25):7882-8.
2005: Christopher Arthur; Anna E Szafranska; Simon E Evans; Stuart C Findlow; Steven G Burston; Philip Owen; Ian Clark-Lewis; Thomas J Simpson; John Crosby; Matthew Crump
Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein.
Biochemistry 2005;44(46):15414-21.
2004: Themis R Kyriakides; Matt J Foster; Grant E Keeney; Annabel Tsai; Cecilia M Giachelli; Ian Clark-Lewis; Barrett J Rollins; Paul Bornstein
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
The American journal of pathology 2004;165(6):2157-66.
2004: Olivier L Fahy; Scott L Townley; Nicholas John Coates; Ian Clark-Lewis; Shaun R McColl
Control of Salmonella dissemination in vivo by macrophage inflammatory protein (MIP)-3alpha/CCL20.
Laboratory investigation; a journal of technical methods and pathology 2004;84(11):1501-11.
2004: Katherine R Pilkington; Ian Clark-Lewis; Shaun R McColl
Inhibition of generation of cytotoxic T lymphocyte activity by a CCL19/macrophage inflammatory protein (MIP)-3beta antagonist.
The Journal of biological chemistry 2004;279(39):40276-82.
2004: Valerie Booth; Ian Clark-Lewis; Brian D Sykes
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).
Protein science : a publication of the Protein Society 2004;13(8):2022-8.
2004: Jiang-Hong Gong; R Yan; J Douglas Waterfield; Ian Clark-Lewis
Post-onset inhibition of murine arthritis using combined chemokine antagonist therapy.
Rheumatology (Oxford, England) 2004;43(1):39-42.
2003: Kunyan Zhang; G Angus McQuibban; Claudia Silva; Georgina S Butler; James B Johnston; Janet Holden; Ian Clark-Lewis; Christopher M Overall; Christopher Power
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration.
Nature neuroscience 2003;6(10):1064-71.
2003: Louise M C Webb; Ian Clark-Lewis; Antonio Alcami
The gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.
Journal of virology 2003;77(15):8588-92.
2003: Patricia Ogilvie; Samantha Paoletti; Ian Clark-Lewis; Mariagrazia Uguccioni
Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes.
Blood 2003;102(3):789-94.
2003: Rachel E Kohler; Adriana C Caon; David O Willenborg; Ian Clark-Lewis; Shaun R McColl
A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6298-306.
2003: Marlene Wolf; Ian Clark-Lewis; C Buri; Hanno Langen; Maddalena Lis; Luca Mazzucchelli
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
The American journal of pathology 2003;162(4):1183-90.
2003: Hans R Lüttichau; Ian Clark-Lewis; Peter Østrup Jensen; Claus Moser; Jan Gerstoft; Thue W Schwartz
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
The Journal of biological chemistry 2003;278(13):10928-33.
2003: Valerie Booth; Carolyn Slupsky; Ian Clark-Lewis; Brian D Sykes
Unmasking ligand binding motifs: identification of a chemokine receptor motif by NMR studies of antagonist peptides.
Journal of molecular biology 2003;327(2):329-34.
2003: Amanda E I Proudfoot; Tracy M Handel; Zoë Johnson; Elaine K Lau; Patricia LiWang; Ian Clark-Lewis; Frédéric Borlat; Timothy Wells; Marie H Kosco-Vilbois
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1885-90.
2003: Ian Clark-Lewis; Ivan Mattioli; Jiang-Hong Gong; Pius Loetscher
Structure-function relationship between the human chemokine receptor CXCR3 and its ligands.
The Journal of biological chemistry 2003;278(1):289-95.
2002: J Cashman; Brad Dykstra; Ian Clark-Lewis; Allen Eaves; Connie Eaves
Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors.
The Journal of experimental medicine 2002;196(9):1141-9.
2002: Valerie Booth; David Keizer; Monique B Kamphuis; Ian Clark-Lewis; Brian D Sykes
The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Biochemistry 2002;41(33):10418-25.
2002: G Angus McQuibban; Jiang-Hong Gong; Julie P Wong; John L Wallace; Ian Clark-Lewis; Christopher M Overall
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.
Blood 2002;100(4):1160-7.
2002: Christopher M Overall; G Angus McQuibban; Ian Clark-Lewis
Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics.
Biological chemistry 2002;383(7-8):1059-66.
2002: Hanno Glimm; Patrick Tang; Ian Clark-Lewis; Christof von Kalle; Connie Eaves
Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice.
Blood 2002;99(9):3454-7.
2002: Charles W Frevert; Richard B Goodman; Michael G Kinsella; Osamu Kajikawa; Kimberly Ballman; Ian Clark-Lewis; Amanda E I Proudfoot; Timothy Wells; Thomas R Martin
Tissue-specific mechanisms control the retention of IL-8 in lungs and skin.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3550-6.
2002: Johanne Cashman; Ian Clark-Lewis; Allen Eaves; Connie Eaves
Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice.
Blood 2002;99(3):792-9.
2001: G Angus McQuibban; Georgina S Butler; Jiang-Hong Gong; Linda Bendall; Christopher Power; Ian Clark-Lewis; Christopher M Overall
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.
The Journal of biological chemistry 2001;276(47):43503-8.
2001: I Kurth; Katharina Willimann; Patrick Schaerli; T Hunziker; Ian Clark-Lewis; Bernhard Moser
Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development.
The Journal of experimental medicine 2001;194(6):855-61.
2001: Patricia Ogilvie; Giuseppe Bardi; Ian Clark-Lewis; Marco Baggiolini; Mariagrazia Uguccioni
Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.
Blood 2001;97(7):1920-4.
2001: MB Delgado; Ian Clark-Lewis; Pius Loetscher; Hanno Langen; M Thelen; Marco Baggiolini; Marlene Wolf
Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.
European journal of immunology 2001;31(3):699-707.
2001: Matthew Crump; EL Elisseeva; J Gong; Ian Clark-Lewis; Brian D Sykes
Structure/function of human herpesvirus-8 MIP-II (1-71) and the antagonist N-terminal segment (1-10).
FEBS letters 2001;489(2-3):171-5.
2001: Pius Loetscher; A Pellegrino; Jiang-Hong Gong; Ivan Mattioli; M Loetscher; Giuseppe Bardi; Marco Baggiolini; Ian Clark-Lewis
The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.
The Journal of biological chemistry 2001;276(5):2986-91.
2000: EL Elisseeva; Carolyn Slupsky; Matthew Crump; Ian Clark-Lewis; Brian D Sykes
NMR studies of active N-terminal peptides of stromal cell-derived factor-1. Structural basis for receptor binding.
The Journal of biological chemistry 2000;275(35):26799-805.
2000: G Angus McQuibban; Jiang-Hong Gong; Eric M Tam; Christopher A McCulloch; Ian Clark-Lewis; Christopher M Overall
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
Science (New York, N.Y.) 2000;289(5482):1202-6.
2000: B Tilton; L Ho; E Oberlin; Pius Loetscher; F Baleux; Ian Clark-Lewis; M Thelen
Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.
The Journal of experimental medicine 2000;192(3):313-24.
2000: David Keizer; Matthew Crump; T W Lee; Carolyn Slupsky; Ian Clark-Lewis; Brian D Sykes
Human CC chemokine I-309, structural consequences of the additional disulfide bond.
Biochemistry 2000;39(20):6053-9.
1999: Johanne Cashman; Ian Clark-Lewis; Allen Eaves; Connie J Eaves
Differentiation stage-specific regulation of primitive human hematopoietic progenitor cycling by exogenous and endogenous inhibitors in an in vivo model.
Blood 1999;94(11):3722-9.
1999: Matthew Crump; Leo Spyracopoulos; P Lavigne; K S Kim; Ian Clark-Lewis; Brian D Sykes
Backbone dynamics of the human CC chemokine eotaxin: fast motions, slow motions, and implications for receptor binding.
Protein science : a publication of the Protein Society 1999;8(10):2041-54.
1999: Shaun R McColl; Ian Clark-Lewis
Inhibition of murine neutrophil recruitment in vivo by CXC chemokine receptor antagonists.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2829-35.
1999: Krishna Rajarathnam; Brian D Sykes; B Dewald; Marco Baggiolini; Ian Clark-Lewis
Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function.
Biochemistry 1999;38(24):7653-8.
1999: Krishna Rajarathnam; Matthew Crump; Ian Clark-Lewis; Brian D Sykes
Spectroscopic characterization of chemokines: relevance for quality control and standardization.
Developments in biological standardization 1999;97():49-57.
1998: Matthew Crump; Krishna Rajarathnam; K S Kim; Ian Clark-Lewis; Brian D Sykes
Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.
The Journal of biological chemistry 1998;273(35):22471-9.
1998: Pius Loetscher; Jiang-Hong Gong; B Dewald; Marco Baggiolini; Ian Clark-Lewis
N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities.
The Journal of biological chemistry 1998;273(35):22279-83.
1998: Philippe A Tessier; Paul H Naccache; K R Diener; Ronald P Gladue; Kuldeep S Neote; Ian Clark-Lewis; Shaun R McColl
Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1204-11.
1998: Katharina Willimann; Daniel F Legler; M Loetscher; Regula Stuber Roos; MB Delgado; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7.
European journal of immunology 1998;28(6):2025-34.
1998: L Piali; C Weber; Greg La Rosa; CR Mackay; Timothy A Springer; Ian Clark-Lewis; Bernhard Moser
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
European journal of immunology 1998;28(3):961-72.
1998: Daniel F Legler; M Loetscher; Regula Stuber Roos; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.
The Journal of experimental medicine 1998;187(4):655-60.
1998: Marlene Wolf; MB Delgado; S A Jones; B Dewald; Ian Clark-Lewis; Marco Baggiolini
Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2.
European journal of immunology 1998;28(1):164-70.
1997: Matthew Crump; Jiang-Hong Gong; Pius Loetscher; Krishna Rajarathnam; Ali Amara; Fernando Arenzana-Seisdedos; Jean-Louis Virelizier; Marco Baggiolini; Brian D Sykes; Ian Clark-Lewis
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.
The EMBO journal 1997;16(23):6996-7007.
1997: AJ Hoogewerf; GS Kuschert; AE Proudfoot; Frédéric Borlat; Ian Clark-Lewis; CA Power; Timothy Wells
Glycosaminoglycans mediate cell surface oligomerization of chemokines.
Biochemistry 1997;36(44):13570-8.
1997: Philippe A Tessier; Paul H Naccache; Ian Clark-Lewis; Ronald P Gladue; Kuldeep S Neote; Shaun R McColl
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3595-602.
1997: Christine A Power; D J Church; A Meyer; Sami Alouani; Amanda E I Proudfoot; Ian Clark-Lewis; S Sozzani; A Mantovani; Timothy Wells
Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
The Journal of experimental medicine 1997;186(6):825-35.
1997: Thomas N Kledal; Mette M Rosenkilde; F Coulin; G Simmons; Anders H Johnsen; Sami Alouani; Christine A Power; Hans R Lüttichau; Jan Gerstoft; Paul R Clapham; Ian Clark-Lewis; Timothy Wells; Thue W Schwartz
A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.
Science (New York, N.Y.) 1997;277(5332):1656-9.
1997: F Coulin; Christine A Power; Sami Alouani; Manuel Peitsch; J M Schroeder; M Moshizuki; Ian Clark-Lewis; Timothy Wells
Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.
European journal of biochemistry / FEBS 1997;248(2):507-15.
1997: Regula Stuber Roos; M Loetscher; Daniel F Legler; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
Identification of CCR8, the receptor for the human CC chemokine I-309.
The Journal of biological chemistry 1997;272(28):17251-4.
1997: Jiang-Hong Gong; Leslie Ratkay; J Douglas Waterfield; Ian Clark-Lewis
An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model.
The Journal of experimental medicine 1997;186(1):131-7.
1997: M D'Apuzzo; A Rolink; M Loetscher; J A Hoxie; Ian Clark-Lewis; Fritz Melchers; Marco Baggiolini; Bernhard Moser
The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4.
European journal of immunology 1997;27(7):1788-93.
1997: S A Jones; B Dewald; Ian Clark-Lewis; Marco Baggiolini
Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2.
The Journal of biological chemistry 1997;272(26):16166-9.
1997: Alshad Lalani; K Graham; Karen Mossman; Krishna Rajarathnam; Ian Clark-Lewis; D Kelvin; Grant McFadden
The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines.
Journal of virology 1997;71(6):4356-63.
1997: Kathryn A Graham; Alshad Lalani; JL Macen; T L Ness; Michele Barry; L Y Liu; Alexandra Lucas; Ian Clark-Lewis; Richard W Moyer; Grant McFadden
The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues.
Virology 1997;229(1):12-24.
1997: Krishna Rajarathnam; Cyril M Kay; B Dewald; Marlene Wolf; Marco Baggiolini; Ian Clark-Lewis; Brian D Sykes
Neutrophil-activating peptide-2 and melanoma growth-stimulatory activity are functional as monomers for neutrophil activation.
The Journal of biological chemistry 1997;272(3):1725-9.
1997: Ian Clark-Lewis; L Vo; P Owen; J Anderson
Chemical synthesis, purification, and folding of C-X-C and C-C chemokines.
Methods in enzymology 1997;287():233-50.
1997: Krishna Rajarathnam; Cyril M Kay; Ian Clark-Lewis; Brian D Sykes
Characterization of quaternary structure of interleukin-8 and functional implications.
Methods in enzymology 1997;287():89-105.
1996: Krishna Rajarathnam; Ian Clark-Lewis; B Dewald; Marco Baggiolini; Brian D Sykes
1H NMR evidence that Glu-38 interacts with the N-terminal functional domain in interleukin-8.
FEBS letters 1996;399(1-2):43-6.
1996: K S Kim; Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.
FEBS letters 1996;395(2-3):277-82.
1996: M Loetscher; B Gerber; Pius Loetscher; S A Jones; L Piali; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
The Journal of experimental medicine 1996;184(3):963-9.
1996: E Oberlin; Ali Amara; Françoise Bachelerie; Christine Bessia; Jean-Louis Virelizier; Fernando Arenzana-Seisdedos; Olivier Schwartz; Jean Michel Heard; Ian Clark-Lewis; Daniel F Legler; M Loetscher; Marco Baggiolini; Bernhard Moser
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.
Nature 1996;382(6594):833-5.
1996: Jiang-Hong Gong; Mariagrazia Uguccioni; B Dewald; Marco Baggiolini; Ian Clark-Lewis
RANTES and MCP-3 antagonists bind multiple chemokine receptors.
The Journal of biological chemistry 1996;271(18):10521-7.
1996: Pius Loetscher; Michael Seitz; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):322-7.
1995: Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
1H NMR solution structure of an active monomeric interleukin-8.
Biochemistry 1995;34(40):12983-90.
1995: Ute Dechert; M Affolter; K W Harder; J Matthews; P Owen; Ian Clark-Lewis; M L Thomas; Ruedi Aebersold; Frank R Jirik
Comparison of the specificity of bacterially expressed cytoplasmic protein-tyrosine phosphatases SHP and SH-PTP2 towards synthetic phosphopeptide substrates.
European journal of biochemistry / FEBS 1995;231(3):673-81.
1995: Ian Clark-Lewis; K S Kim; Krishna Rajarathnam; Jiang-Hong Gong; B Dewald; Bernhard Moser; Marco Baggiolini; Brian D Sykes
Structure-activity relationships of chemokines.
Journal of leukocyte biology 1995;57(5):703-11.
1995: D H Ng; K W Harder; Ian Clark-Lewis; Frank R Jirik; Pauline Johnson
Non-radioactive method to measure CD45 protein tyrosine phosphatase activity isolated directly from cells.
Journal of immunological methods 1995;179(2):177-85.
1995: Douglas A Carlow; Jamey D Marth; Ian Clark-Lewis; Hung-Sia Teh
Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1724-34.
1995: Jiang-Hong Gong; Ian Clark-Lewis
Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues.
The Journal of experimental medicine 1995;181(2):631-40.
1994: K S Kim; Ian Clark-Lewis; Brian D Sykes
Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy.
The Journal of biological chemistry 1994;269(52):32909-15.
1994: Pius Loetscher; Michael Seitz; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(13):1055-60.
1994: Hermann J Ziltener; Ian Clark-Lewis; A T Jones; M Dy
Carbohydrate does not modulate the in vivo effects of injected interleukin-3.
Experimental hematology 1994;22(11):1070-5.
1994: Ian Clark-Lewis; B Dewald; M Loetscher; Bernhard Moser; Marco Baggiolini
Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids.
The Journal of biological chemistry 1994;269(23):16075-81.
1994: Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
1H NMR studies of interleukin 8 analogs: characterization of the domains essential for function.
Biochemistry 1994;33(21):6623-30.
1994: Krishna Rajarathnam; Brian D Sykes; Cyril M Kay; B Dewald; T Geiser; Marco Baggiolini; Ian Clark-Lewis
Neutrophil activation by monomeric interleukin-8.
Science (New York, N.Y.) 1994;264(5155):90-2.
1994: Pius Loetscher; Michael Seitz; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2.
FEBS letters 1994;341(2-3):187-92.
1994: K W Harder; P Owen; L K Wong; Ruedi Aebersold; Ian Clark-Lewis; Frank R Jirik
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides.
The Biochemical journal 1994;298 ( Pt 2)():395-401.
1994: Marco Baggiolini; Bernhard Moser; Ian Clark-Lewis
Interleukin-8 and related chemotactic cytokines. The Giles Filley Lecture.
Chest 1994;105(3 Suppl):95S-98S.
1994: Ute Dechert; M Adam; K W Harder; Ian Clark-Lewis; Frank R Jirik
Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains.
The Journal of biological chemistry 1994;269(8):5602-11.
1993: T Geiser; B Dewald; M U Ehrengruber; Ian Clark-Lewis; Marco Baggiolini
The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes.
The Journal of biological chemistry 1993;268(21):15419-24.
1993: B Federsppiel; I G Melhado; AM Duncan; A Delaney; K Schappert; Ian Clark-Lewis; Frank R Jirik
Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen.
Genomics 1993;16(3):707-12.
1993: Ian Clark-Lewis; B Dewald; T Geiser; Bernhard Moser; Marco Baggiolini
Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3574-7.
1993: Bernhard Moser; B Dewald; L Barella; C Schumacher; Marco Baggiolini; Ian Clark-Lewis
Interleukin-8 antagonists generated by N-terminal modification.
The Journal of biological chemistry 1993;268(10):7125-8.
1992: C Schumacher; Ian Clark-Lewis; Marco Baggiolini; Bernhard Moser
High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10542-6.
1992: Vincent Duronio; Ian Clark-Lewis; B Federsppiel; J S Wieler; John W Schrader
Tyrosine phosphorylation of receptor beta subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor.
The Journal of biological chemistry 1992;267(30):21856-63.
1992: Marco Baggiolini; Ian Clark-Lewis
Interleukin-8, a chemotactic and inflammatory cytokine.
FEBS letters 1992;307(1):97-101.
1992: L A Charlton; Jasbinder S Sanghera; Ian Clark-Lewis; Steven Pelech
Structure-function analysis of casein kinase 2 with synthetic peptides and anti-peptide antibodies.
The Journal of biological chemistry 1992;267(13):8840-5.
1992: Vincent Duronio; Ian Clark-Lewis; John W Schrader
Two polypeptides identified by interleukin 3 cross-linking represent distinct components of the interleukin 3 receptor.
Experimental hematology 1992;20(4):505-11.
1992: B Dewald; Bernhard Moser; L Barella; C Schumacher; Marco Baggiolini; Ian Clark-Lewis
IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties.
Immunology letters 1992;32(1):81-4.
1992: Julian D Watts; G M Wilson; E Ettenhadieh; Ian Clark-Lewis; C A Kubanek; Caroline R Astell; Jamey D Marth; Ruedi Aebersold
Purification and initial characterization of the lymphocyte-specific protein-tyrosyl kinase p56lck from a baculovirus expression system.
The Journal of biological chemistry 1992;267(2):901-7.
1991: Ian Clark-Lewis; C Schumacher; Marco Baggiolini; Bernhard Moser
Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.
The Journal of biological chemistry 1991;266(34):23128-34.
1991: Robert S Molday; Laurie L Molday; A Dosé; Ian Clark-Lewis; M Illing; N J Cook; E Eismann; U Benjamin Kaupp
The cGMP-gated channel of the rod photoreceptor cell characterization and orientation of the amino terminus.
The Journal of biological chemistry 1991;266(32):21917-22.
1991: A Walz; F Meloni; Ian Clark-Lewis; Vinzenz von Tscharner; Marco Baggiolini
[Ca2+]i changes and respiratory burst in human neutrophils and monocytes induced by NAP-1/interleukin-8, NAP-2, and gro/MGSA.
Journal of leukocyte biology 1991;50(3):279-86.
1991: Vincent Duronio; S R Granleese; Ian Clark-Lewis; John W Schrader; Hermann J Ziltener
Antibodies to interleukin 3 as probes for the interaction of interleukin 3 with its receptor.
Cytokine 1991;3(5):414-20.
1991: Ian Clark-Lewis; Jasbinder S Sanghera; Steven Pelech
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.
The Journal of biological chemistry 1991;266(23):15180-4.
1991: M Samiei; M Daya-Makin; Ian Clark-Lewis; Steven Pelech
Platelet-activating factor- and thrombin-induced stimulation of p34cdc2-cyclin histone H1 kinase activity in platelets.
The Journal of biological chemistry 1991;266(23):14889-92.
1991: Bernhard Moser; C Schumacher; Vinzenz von Tscharner; Ian Clark-Lewis; Marco Baggiolini
Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils.
The Journal of biological chemistry 1991;266(16):10666-71.
1991: Ian Clark-Lewis; Bernhard Moser; A Walz; Marco Baggiolini; G J Scott; Ruedi Aebersold
Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.
Biochemistry 1991;30(12):3128-35.
1991: M K Hockertz; Ian Clark-Lewis; E Peter M Candido
Studies of the small heat shock proteins of Caenorhabditis elegans using anti-peptide antibodies.
FEBS letters 1991;280(2):375-8.
1991: D E Yeung; G W Brown; P Tam; R H Russnak; G Wilson; Ian Clark-Lewis; Caroline R Astell
Monoclonal antibodies to the major nonstructural nuclear protein of minute virus of mice.
Virology 1991;181(1):35-45.
1990: Bernhard Moser; Ian Clark-Lewis; R Zwahlen; Marco Baggiolini
Neutrophil-activating properties of the melanoma growth-stimulatory activity.
The Journal of experimental medicine 1990;171(5):1797-802.
1988: John W Schrader; K B Leslie; Ian Clark-Lewis; Hermann J Ziltener; S Schrader
Growth factor-related mechanisms of leukemogenesis.
Advances in experimental medicine and biology 1988;241():265-71.