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James Clark

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Paresh Thakker; Stanley Wolf; Andrew Wood; James D Clark; Mary Collins; Samuel J Goldman; Vijay K Kuchroo; Michael W Leach; Katherine L Lee; Suzana Marusic; John C McKew; Nancy L Stedman; Mina Hassan-Zahraee
Cytosolic phospholipase A2α blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Cheryl L Nickerson-Nutter; Debra Goodwin; Marina W H Shen; Christy Damphousse; Weili Duan; Tarek A Samad; John C McKew; Katherine L Lee; Margaret M Zaleska; Nevena Mollova; James D Clark
The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.
Tsung H Lin; Martin Hegen; Elizabeth Quadros; Cheryl L Nickerson-Nutter; Kenneth C Appell; Andrew G Cole; Yuefei Shao; Steve Tam; Michael Ohlmeyer; Bojing Wang; Debra G Goodwin; Earl F Kimble; Jorge Quintero; Min Gao; Peter Symanowicz; Christopher Wrocklage; Jennifer Lussier; Scott H Schelling; Amha G Hewet; Dejun Xuan; Rustem Krykbaev; Jenny Togias; Xin Xu; Richard Harrison; Tarek Mansour; Mary Collins; James D Clark; Maria L Webb; Katherine J Seidl
Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.

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All Publications

2011: Paresh Thakker; Stanley Wolf; Andrew Wood; James D Clark; Mary Collins; Samuel J Goldman; Vijay K Kuchroo; Michael W Leach; Katherine L Lee; Suzana Marusic; John C McKew; Nancy L Stedman; Mina Hassan-Zahraee
Cytosolic phospholipase A2α blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1986-97.
2011: Cheryl L Nickerson-Nutter; Debra Goodwin; Marina W H Shen; Christy Damphousse; Weili Duan; Tarek A Samad; John C McKew; Katherine L Lee; Margaret M Zaleska; Nevena Mollova; James D Clark
The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.
Neuropharmacology 2011;60(4):633-41.
2010: Tsung H Lin; Martin Hegen; Elizabeth Quadros; Cheryl L Nickerson-Nutter; Kenneth C Appell; Andrew G Cole; Yuefei Shao; Steve Tam; Michael Ohlmeyer; Bojing Wang; Debra G Goodwin; Earl F Kimble; Jorge Quintero; Min Gao; Peter Symanowicz; Christopher Wrocklage; Jennifer Lussier; Scott H Schelling; Amha G Hewet; Dejun Xuan; Rustem Krykbaev; Jenny Togias; Xin Xu; Richard Harrison; Tarek Mansour; Mary Collins; James D Clark; Maria L Webb; Katherine J Seidl
Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
Arthritis and rheumatism 2010;62(8):2283-93.
2009: Steven J Kirincich; Jason Xiang; Neal Green; Steve Tam; Hui Y Yang; Jaechul Shim; Marina W H Shen; James D Clark; John C McKew
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.
Bioorganic & medicinal chemistry 2009;17(13):4383-405.
2009: Lihren Chen; Weiheng Wang; Katherine L Lee; Marina W H Shen; Elizabeth A Murphy; Wen Zhang; Xin Xu; Steve Tam; Cheryl Nickerson-Nutter; Debra G Goodwin; James D Clark; John C McKew
Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
Journal of medicinal chemistry 2009;52(4):1156-71.
2008: Manjunath K Ramarao; Marina W H Shen; Elizabeth A Murphy; Weili Duan; Yajuan Zhao; John McKew; Katherine L Lee; Paresh Thakker; Mark L Behnke; James D Clark
Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
Analytical biochemistry 2008;383(2):217-25.
2008: Suzana Marusic; Paresh Thakker; Jeffrey W Pelker; Nancy L Stedman; Katherine L Lee; John C McKew; Lixin Han; Xin Xu; Stanley Wolf; Adam J Borey; Junqing Cui; Marina W H Shen; Fran Donahue; Mina Hassan-Zahraee; Michael W Leach; Takao Shimizu; James D Clark
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
Journal of neuroimmunology 2008;204(1-2):29-37.
2008: John C McKew; Katherine L Lee; Marina W H Shen; Paresh Thakker; Megan A Foley; Mark L Behnke; B Hu; Fuk-Wah Sum; Steve Tam; Yonghan Hu; Lihren Chen; Steven J Kirincich; Ronald Michalak; Jennifer Thomason; Manus Ipek; Kun Wu; Lane Wooder; Manjunath K Ramarao; Elizabeth A Murphy; Debra G Goodwin; Leo Albert; Xin Xu; Frances Donahue; M Sherry Ku; James Carl Keith; Cheryl L Nickerson-Nutter; William W Abraham; Cara Williams; Martin Hegen; James D Clark
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
Journal of medicinal chemistry 2008;51(12):3388-413.
2008: Katherine L Lee; Mark L Behnke; Megan A Foley; Lihren Chen; Weiheng Wang; Richard Vargas; Jill Nunez; Steve Tam; Nevena Mollova; Xin Xu; Marina W H Shen; Manjunath K Ramarao; Debra G Goodwin; Cheryl Nickerson-Nutter; William W Abraham; Cara Williams; James D Clark; John C McKew
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorganic & medicinal chemistry 2008;16(3):1345-58.
2007: J Perry Hall; Yahya Kurdi; Sang Hsu; John W Cuozzo; Julie Liu; Jean-Baptiste Telliez; Katherine J Seidl; Aaron Winkler; Yonghan Hu; Neal Green; G Roger Askew; Steve Tam; James D Clark; Lih-Ling Lin
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
The Journal of biological chemistry 2007;282(46):33295-304.
2007: Katherine L Lee; Megan A Foley; Lihren Chen; Mark L Behnke; Frank Lovering; Steven J Kirincich; Weiheng Wang; Jaechul Shim; Steve Tam; Marina W H Shen; Soo Peang Khor; Xin Xu; Debra G Goodwin; Manjunath K Ramarao; Cheryl Nickerson-Nutter; Frances Donahue; M Sherry Ku; James D Clark; John C McKew
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Journal of medicinal chemistry 2007;50(6):1380-400.
2006: Ariamala Gopalsamy; Hui Yang; John W Ellingboe; John C McKew; Steve Tam; Diane Joseph-McCarthy; Wen Zhang; Marina Shen; James D Clark
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):2978-81.
2006: John C McKew; Megan A Foley; Paresh Thakker; Mark L Behnke; Frank Lovering; Fuk-Wah Sum; Steve Tam; Kun Wu; Marina W H Shen; Wen Zhang; Mario Gonzalez; Shanghao Liu; Anu Mahadevan; Howard Sard; Soo Peang Khor; James D Clark
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
Journal of medicinal chemistry 2006;49(1):135-58.
2005: Suzana Marusic; Michael W Leach; Jeffrey W Pelker; Mihai L Azoitei; Naonori Uozumi; Junqing Cui; Marina W H Shen; Charlene M DeClercq; Joy S Miyashiro; Brenda A Carito; Paresh Thakker; David L Simmons; John P Leonard; Takao Shimizu; James D Clark
Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2005;202(6):841-51.
2005: Manjunath K Ramarao; Elizabeth A Murphy; Marina W H Shen; Yuren Wang; Kristen N Bushell; Nelson Huang; Ning Pan; Cara Williams; James D Clark
A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
Analytical biochemistry 2005;343(1):143-51.
2003: John C McKew; Frank Lovering; James D Clark; Jean Bemis; YiBin Xiang; Marina Shen; Wen Zhang; Juan Alvarez; Diane Joseph-McCarthy
Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.
Bioorganic & medicinal chemistry letters 2003;13(24):4501-4.
2003: Martin Hegen; Linhong Sun; Naonori Uozumi; Kazuhiko Kume; Mary E Goad; Cheryl Nickerson-Nutter; Takao Shimizu; James D Clark
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
The Journal of experimental medicine 2003;197(10):1297-302.