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James Clark
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Research Profile (preview)
Chemicals & Drugs
Concepts & Ideas
Anatomy
Living Beings
Genes & Molecular Sequences
Disorders
Procedures
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Network (preview)
10
Shen, Marina
9
McKew, John
8
Tam, Steve
5
Ramarao, Manjunath
5
Xu, Xin
4
Zhang, Wen
4
Nickerson-Nutter, Cheryl
4
Chen, Lihren
3
Kirincich, Steven
3
Lovering, Frank
3
Wang, Weiheng
2
Hegen, Martin
2
Joseph-McCarthy, Diane
2
Khor, Soo Peang
2
Sum, Fuk-Wah
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Publications
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Geonetwork of James Clark (preview)
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All Publications
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2009: Kirincich Steven J; Xiang Jason; Green Neal; Tam Steve; Yang Hui Y; Shim Jaechul; Shen Marina W H; Clark James D; McKew John C
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.
Bioorganic & medicinal chemistry 2009;17(13):4383-405.
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2009: Chen Lihren; Wang Weiheng; Lee Katherine L; Shen Marina W H; Murphy Elizabeth A; Zhang Wen; Xu Xin; Tam Steve; Nickerson-Nutter Cheryl; Goodwin Debra G; Clark James D; McKew John C
Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
Journal of medicinal chemistry 2009;52(4):1156-71.
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2008: Ramarao Manjunath K; Shen Marina W H; Murphy Elizabeth A; Duan Weili; Zhao Yajuan; McKew John; Lee Katherine L; Thakker Paresh; Behnke Mark L; Clark James D
Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
Analytical biochemistry 2008;383(2):217-25.
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2008: Marusic Suzana; Thakker Paresh; Pelker Jeffrey W; Stedman Nancy L; Lee Katherine L; McKew John C; Han Lixin; Xu Xin; Wolf Stan F; Borey Adam J; Cui Junqing; Shen Marina W H; Donahue Fran; Hassan-Zahraee Mina; Leach Michael W; Shimizu Takao; Clark James D
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
Journal of neuroimmunology 2008;204(1-2):29-37.
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2008: McKew John C; Lee Katherine L; Shen Marina W H; Thakker Paresh; Foley Megan A; Behnke Mark L; Hu Baihua; Sum Fuk-Wah; Tam Steve; Hu Yonghan; Chen Lihren; Kirincich Steven J; Michalak Ronald; Thomason Jennifer; Ipek Manus; Wu Kun; Wooder Lane; Ramarao Manjunath K; Murphy Elizabeth A; Goodwin Debra G; Albert Leo; Xu Xin; Donahue Frances; Ku M Sherry; Keith James; Nickerson-Nutter Cheryl L; Abraham William M; Williams Cara; Hegen Martin; Clark James D
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
Journal of medicinal chemistry 2008;51(12):3388-413.
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2008: Lee Katherine L; Behnke Mark L; Foley Megan A; Chen Lihren; Wang Weiheng; Vargas Richard; Nunez Jill; Tam Steve; Mollova Nevena; Xu Xin; Shen Marina W H; Ramarao Manjunath K; Goodwin Debra G; Nickerson-Nutter Cheryl L; Abraham William M; Williams Cara; Clark James D; McKew John C
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorganic & medicinal chemistry 2008;16(3):1345-58.
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2007: Hall J Perry; Kurdi Yahya; Hsu Sang; Cuozzo John; Liu Julie; Telliez Jean-Baptiste; Seidl Katherine J; Winkler Aaron; Hu Yonghan; Green Neal; Askew G Roger; Tam Steve; Clark James D; Lin Lih-Ling
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
The Journal of biological chemistry 2007;282(46):33295-304.
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2007: Lee Katherine L; Foley Megan A; Chen Lihren; Behnke Mark L; Lovering Frank E; Kirincich Steven J; Wang Weiheng; Shim Jaechul; Tam Steve; Shen Marina W H; Khor Soopeang; Xu Xin; Goodwin Debra G; Ramarao Manjunath K; Nickerson-Nutter Cheryl; Donahue Frances; Ku M Sherry; Clark James D; McKew John C
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Journal of medicinal chemistry 2007;50(6):1380-400.
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2006: Gopalsamy Ariamala; Yang Hui; Ellingboe John W; McKew John C; Tam Steve; Joseph-McCarthy Diane; Zhang Wen; Shen Marina; Clark James D
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):2978-81.
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2006: McKew John C; Foley Megan A; Thakker Paresh; Behnke Mark L; Lovering Frank E; Sum Fuk-Wah; Tam Steve; Wu Kun; Shen Marina W H; Zhang Wen; Gonzalez Mario; Liu Shanghao; Mahadevan Anu; Sard Howard; Khor Soo Peang; Clark James D
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
Journal of medicinal chemistry 2006;49(1):135-58.
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2005: Marusic Suzana; Leach Michael W; Pelker Jeffrey W; Azoitei Mihai L; Uozumi Naonori; Cui Junqing; Shen Marina W H; DeClercq Charlene M; Miyashiro Joy S; Carito Brenda A; Thakker Paresh; Simmons David L; Leonard John P; Shimizu Takao; Clark James D
Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2005;202(6):841-51.
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2005: Ramarao Manjunath K; Murphy Elizabeth A; Shen Marina W H; Wang Yuren; Bushell Kristen N; Huang Nelson; Pan Ning; Williams Cara; Clark James D
A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
Analytical biochemistry 2005;343(1):143-51.
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2003: McKew John C; Lovering Frank; Clark James D; Bemis Jean; Xiang YiBin; Shen Marina; Zhang Wen; Alvarez Juan C; Joseph-McCarthy Diane
Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.
Bioorganic & medicinal chemistry letters 2003;13(24):4501-4.
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2003: Hegen Martin; Sun Linhong; Uozumi Naonori; Kume Kazuhiko; Goad Mary E; Nickerson-Nutter Cheryl L; Shimizu Takao; Clark James D
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
The Journal of experimental medicine 2003;197(10):1297-302.
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