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John Clark

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TOP 3
John I Clark
Self-assembly of protein aggregates in ageing disorders: the lens and cataract model.
Tyler J W Clark; Scott A Houck; John I Clark
Hemoglobin interactions with αB crystallin: a direct test of sensitivity to protein instability.
Scott A Houck; Andrew Landsbury; John I Clark; Roy A Quinlan
Multiple sites in αB-crystallin modulate its interactions with desmin filaments assembled in vitro.

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All Publications

2013: John I Clark
Self-assembly of protein aggregates in ageing disorders: the lens and cataract model.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1617):20120104.
2012: Tyler J W Clark; Scott A Houck; John I Clark
Hemoglobin interactions with αB crystallin: a direct test of sensitivity to protein instability.
PloS one 2012;7(7):e40486.
2011: Scott A Houck; Andrew Landsbury; John I Clark; Roy A Quinlan
Multiple sites in αB-crystallin modulate its interactions with desmin filaments assembled in vitro.
PloS one 2011;6(11):e25859.
2009: Teri Seeberger Greiling; John I Clark
Early lens development in the zebrafish: a three-dimensional time-lapse analysis.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(9):2254-65.
2009: Teri Seeberger Greiling; Brad Stone; John I Clark
Absence of SPARC leads to impaired lens circulation.
Experimental eye research 2009;89(3):416-25.
2008: Jenny Yuen; Yi Li; Linda Shapiro; John I Clark; Ernest Arnett; E Helene Sage; James F Brinkley
Automated, computerized, feature-based phenotype analysis of slit lamp images of the mouse lens.
Experimental eye research 2008;86(4):562-75.
2008: Teri Seeberger Greiling; John I Clark
The transparent lens and cornea in the mouse and zebra fish eye.
Seminars in cell & developmental biology 2008;19(2):94-9.
2008: Paul J Muchowski; Richard Ramsden; QuangVu Nguyen; Ernest E Arnett; Teri Seeberger Greiling; Susan K Anderson; John I Clark
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.
The Journal of biological chemistry 2008;283(10):6330-6.
2008: Joy Ghosh; Scott A Houck; John I Clark
Interactive sequences in the molecular chaperone, human alphaB crystallin modulate the fibrillation of amyloidogenic proteins.
The international journal of biochemistry & cell biology 2008;40(5):954-67.
2007: Norihito Gotoh; Nikole Perdue; Hiroyuki Matsushima; E Helene Sage; Qi Yan; John I Clark
An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.
Investigative ophthalmology & visual science 2007;48(10):4679-87.
2007: Joy Ghosh; Ananth K Shenoy; John I Clark
Interactions between important regulatory proteins and human alphaB crystallin.
Biochemistry 2007;46(21):6308-17.
2007: Joy Ghosh; Scott A Houck; John I Clark
Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments.
The international journal of biochemistry & cell biology 2007;39(10):1804-15.
2007: Joy Ghosh; Scott A Houck; John I Clark
Interactive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassembly.
PloS one 2007;2(6):e498.
2006: Joy Ghosh; Scott A Houck; Catalin E Doneanu; John I Clark
The beta4-beta8 groove is an ATP-interactive site in the alpha crystallin core domain of the small heat shock protein, human alphaB crystallin.
Journal of molecular biology 2006;364(3):364-75.
2006: Joy Ghosh; Ananth K Shenoy; John I Clark
N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates.
Biochemistry 2006;45(46):13847-54.
2006: Joy Ghosh; Marcus R Estrada; John I Clark
Structure-based analysis of the beta8 interactive sequence of human alphaB crystallin.
Biochemistry 2006;45(32):9878-86.
2006: Ryan O Emerson; E Helene Sage; Joy Ghosh; John I Clark
Chaperone-like activity revealed in the matricellular protein SPARC.
Journal of cellular biochemistry 2006;98(4):701-5.
2006: Lingyun Liu; Joy Ghosh; John I Clark; Shaoyi Jiang
Studies of alphaB crystallin subunit dynamics by surface plasmon resonance.
Analytical biochemistry 2006;350(2):186-95.
2006: Joy Ghosh; Marcus R Estrada; Scott A Houck; John I Clark
The function of the beta3 interactive domain in the small heat shock protein and molecular chaperone, human alphaB crystallin.
Cell stress & chaperones 2006;11(2):187-97.
2005: Joy Ghosh; Marcus R Estrada; John I Clark
Interactive domains for chaperone activity in the small heat shock protein, human alphaB crystallin.
Biochemistry 2005;44(45):14854-69.
2005: Joy Ghosh; John I Clark
Insights into the domains required for dimerization and assembly of human alphaB crystallin.
Protein science : a publication of the Protein Society 2005;14(3):684-95.
2004: Vesna Zderic; John I Clark; Roy W Martin; Shahram Vaezy
Ultrasound-enhanced transcorneal drug delivery.
Cornea 2004;23(8):804-11.
2004: Vesna Zderic; John I Clark; Shahram Vaezy
Drug delivery into the eye with the use of ultrasound.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2004;23(10):1349-59.
2004: John I Clark
Order and disorder in the transparent media of the eye.
Experimental eye research 2004;78(3):427-32.
2002: Vesna Zderic; Shahram Vaezy; Roy W Martin; John I Clark
Ocular drug delivery using 20-kHz ultrasound.
Ultrasound in medicine & biology 2002;28(6):823-9.
2002: Arpenik Avakian; Robert E Kalina; E Helene Sage; Avni H Rambhia; Katherine E Elliott; Elaine L Chuang; John I Clark; Jenq-Neng Hwang; Patricia Parsons-Wingerter
Fractal analysis of region-based vascular change in the normal and non-proliferative diabetic retina.
Current eye research 2002;24(4):274-80.
2002: Melissa M Valdez; John I Clark; Gabrielle J S Wu; Paul J Muchowski
Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human alphaB-crystallin.
European journal of biochemistry / FEBS 2002;269(7):1806-13.
2001: Barry K Derham; Martinus A M van Boekel; Paul J Muchowski; John I Clark; J Horwitz; HW Hepburne-Scott; Wilfried W de Jong; M James C Crabbe; John J Harding
Chaperone function of mutant versions of alpha A- and alpha B-crystallin prepared to pinpoint chaperone binding sites.
European journal of biochemistry / FEBS 2001;268(3):713-21.
2000: Kazumi Norose; Woo-Kuen Lo; John I Clark; E Helene Sage; CC Howe
Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface.
Experimental eye research 2000;71(3):295-307.
2000: Patricia Parsons-Wingerter; Katherine E Elliott; John I Clark; Andrew G Farr
Fibroblast growth factor-2 selectively stimulates angiogenesis of small vessels in arterial tree.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(5):1250-6.
2000: Patricia Parsons-Wingerter; Katherine E Elliott; Andrew G Farr; K Radhakrishnan; John I Clark; E Helene Sage
Generational analysis reveals that TGF-beta1 inhibits the rate of angiogenesis in vivo by selective decrease in the number of new vessels.
Microvascular research 2000;59(2):221-32.
2000: John I Clark; Paul J Muchowski
Small heat-shock proteins and their potential role in human disease.
Current opinion in structural biology 2000;10(1):52-9.
2000: John I Clark; JM Clark
Lens cytoplasmic phase separation.
International review of cytology 2000;192():171-87.
1999: Ming Der Perng; Paul J Muchowski; Paul van den IJssel; Gabrielle J S Wu; Aileen M Hutcheson; John I Clark; Roy A Quinlan
The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro.
The Journal of biological chemistry 1999;274(47):33235-43.
1999: Paul J Muchowski; L G Hays; J R Yates; John I Clark
ATP and the core "alpha-Crystallin" domain of the small heat-shock protein alphaB-crystallin.
The Journal of biological chemistry 1999;274(42):30190-5.
1999: Paul J Muchowski; Gabrielle J S Wu; J J Liang; Elinor T Adman; John I Clark
Site-directed mutations within the core "alpha-crystallin" domain of the small heat-shock protein, human alphaB-crystallin, decrease molecular chaperone functions.
Journal of molecular biology 1999;289(2):397-411.
1999: John I Clark; H Matsushima; Larry L David; J M Clark
Lens cytoskeleton and transparency: a model.
Eye (London, England) 1999;13 ( Pt 3b)():417-24.
1999: Paul J Muchowski; M M Valdez; John I Clark
AlphaB-crystallin selectively targets intermediate filament proteins during thermal stress.
Investigative ophthalmology & visual science 1999;40(5):951-8.
1999: James A Bassuk; Ted A Birkebak; Justin D Rothmier; JM Clark; Amy D Bradshaw; Paul J Muchowski; CC Howe; John I Clark; E Helene Sage
Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation.
Experimental eye research 1999;68(3):321-31.
1998: Kazumi Norose; John I Clark; N A Syed; A Basu; Ellen Heber-Katz; E Helene Sage; CC Howe
SPARC deficiency leads to early-onset cataractogenesis.
Investigative ophthalmology & visual science 1998;39(13):2674-80.
1998: Patricia Parsons-Wingerter; B Lwai; M C Yang; Katherine E Elliott; A Milaninia; A Redlitz; John I Clark; E Helene Sage
A novel assay of angiogenesis in the quail chorioallantoic membrane: stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection.
Microvascular research 1998;55(3):201-14.
1998: Paul J Muchowski; John I Clark
ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1004-9.
1997: H Matsushima; Elaine Peskind; JM Clark; James B Leverenz; Charles William Wilkinson; John I Clark
Protein changes during aging and the effects of long-term cortisol treatment in macaque monkey lens.
Optometry and vision science : official publication of the American Academy of Optometry 1997;74(4):190-7.
1997: H Matsushima; Larry L David; T Hiraoka; John I Clark
Loss of cytoskeletal proteins and lens cell opacification in the selenite cataract model.
Experimental eye research 1997;64(3):387-95.
1997: Paul J Muchowski; James A Bassuk; N H Lubsen; John I Clark
Human alphaB-crystallin. Small heat shock protein and molecular chaperone.
The Journal of biological chemistry 1997;272(4):2578-82.
1996: John I Clark; Q L Huang
Modulation of the chaperone-like activity of bovine alpha-crystallin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15185-9.
1996: John I Clark; John Livesey; J E Steele
Delay or inhibition of rat lens opacification using pantethine and WR-77913.
Experimental eye research 1996;62(1):75-84.
1996: T Hiraoka; John I Clark; X Y LI; George M Thurston
Effect of selected anti-cataract agents on opacification in the selenite cataract model.
Experimental eye research 1996;62(1):11-9.
1995: T Hiraoka; John I Clark
Inhibition of lens opacification during the early stages of cataract formation.
Investigative ophthalmology & visual science 1995;36(12):2550-5.
1995: Shahram Vaezy; L T Smith; A Milaninia; John I Clark
Two-dimensional fourier analysis of electron micrographs of human skin for quantification of the collagen fiber organization in the dermis.
Journal of electron microscopy 1995;44(5):358-64.
1995: Shahram Vaezy; John I Clark
Characterization of the cellular microstructure of ocular lens using 2D power law analysis.
Annals of biomedical engineering 1995;23(4):482-90.
1995: Shahram Vaezy; John I Clark; J M Clark
Quantitative analysis of the lens cell microstructure in selenite cataract using a two-dimensional Fourier analysis.
Experimental eye research 1995;60(3):245-55.
1994: Shahram Vaezy; John I Clark
Quantitative analysis of the microstructure of the human cornea and sclera using 2-D Fourier methods.
Journal of microscopy 1994;175(Pt 2):93-9.
1994: John I Clark
Lens cytoplasmic protein solutions: analysis of a biologically occurring aqueous phase separation.
Methods in enzymology 1994;228():525-37.
1993: John I Clark; John Livesey; J E Steele
Phase separation inhibitors and lens transparency.
Optometry and vision science : official publication of the American Academy of Optometry 1993;70(11):873-9.
1992: B Brewitt; David C Teller; John I Clark
Periods of oscillatory growth in developing ocular lens correspond with cell cycle times.
Journal of cellular physiology 1992;150(3):586-92.
1992: John I Clark; J E Steele
Phase-separation inhibitors and prevention of selenite cataract.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1720-4.
1991: M Gisselberg; John I Clark; Shahram Vaezy; T B Osgood
A quantitative evaluation of Fourier components in transparent and opaque calf cornea.
The American journal of anatomy 1991;191(4):408-18.
1991: Shahram Vaezy; John I Clark
A quantitative analysis of transparency in the human sclera and cornea using Fourier methods.
Journal of microscopy 1991;163(Pt 1):85-94.
1990: C F Beaulieu; John I Clark
31P nuclear magnetic resonance and laser spectroscopic analyses of lens transparency during calcium-induced opacification.
Investigative ophthalmology & visual science 1990;31(7):1339-47.
1990: B Brewitt; John I Clark
A new method for study of normal lens development in vitro using pulsatile delivery of PDGF or EGF in HL-1 serum-free medium.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(3 Pt 1):305-14.
1989: C F Beaulieu; R D Brown; John I Clark; M Spiller; S H Koenig
Relaxometry of lens homogenates. II. Temperature dependence and comparison with other proteins.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1989;10(3):362-72.
1989: Venkat N Reddy; H Ikebe; Frank J Giblin; John I Clark; John Livesey
Effect of radioprotective agents on X-ray cataracts.
Lens and eye toxicity research 1989;6(4):573-88.
1989: John I Clark; C F Beaulieu
From E.M. microprobe analysis to NMRD studies of the lens.
Lens and eye toxicity research 1989;6(4):523-39.
1988: B Brewitt; John I Clark
Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF.
Science (New York, N.Y.) 1988;242(4879):777-9.
1988: John I Clark; M E Danford-Kaplan; M Delaye
Calcium decreases transparency of homogenate from lens cortex and has no effect on nucleus.
Experimental eye research 1988;47(3):447-55.
1988: C F Beaulieu; John I Clark; R D Brown; M Spiller; S H Koenig
Relaxometry of calf lens homogenates, including cross-relaxation by crystallin NH groups.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1988;8(1):45-57.
1987: John I Clark; T B Osgood; S J Trask
Inhibition of phase separation by reagents that prevent X-irradiation cataract in vivo.
Experimental eye research 1987;45(6):961-7.
1987: M Delaye; M E Danford-Kaplan; John I Clark; B Krop; T Gulik-Krzywicki; A Tardieu
Effect of calcium on the calf lens cytoplasm.
Experimental eye research 1987;44(5):601-16.
1986: T B Osgood; T W Menard; John I Clark; Kenneth A Krohn
Inhibition of lens opacification in x-irradiated rats treated with WR-77913.
Investigative ophthalmology & visual science 1986;27(12):1780-4.
1986: T W Menard; T B Osgood; John I Clark; Alexander M Spence; J E Steele; Kenneth A Krohn; John Livesey
Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats.
International journal of radiation oncology, biology, physics 1986;12(8):1483-6.
1985: J R Neuringer; John I Clark; George B. Benedek
A quantitative microprobe analysis of elements in cortical and nuclear cells of the calf lens.
The Anatomical record 1985;211(3):329-37.
1984: I Nishio; J N Weiss; T Tanaka; John I Clark; Frank J Giblin; V N Reddy; George B. Benedek
In vivo observation of lens protein diffusivity in normal and X-irradiated rabbit lenses.
Experimental eye research 1984;39(1):61-8.
1982: John I Clark; Frank J Giblin; V N Reddy; George B. Benedek
Phase separation of X-irradiated lenses of rabbit.
Investigative ophthalmology & visual science 1982;22(2):186-90.
1981: M Delaye; John I Clark; George B. Benedek
Coexistence curves for the phase separation in the calf lens cytoplasm.
Biochemical and biophysical research communications 1981;100(2):908-14.
1981: John I Clark; M Delaye; P Hammer; L Mengel
Preparation and characterization of native lens cell cytoplasm.
Current eye research 1981;1(12):695-704.
1980: John I Clark; L Mengel; A Bagg; George B. Benedek
Cortical opacity, calcium concentration and fiber membrane structure in the calf lens.
Experimental eye research 1980;31(4):399-410.
1980: John I Clark; George B. Benedek
Phase diagram for cell cytoplasm from the calf lens.
Biochemical and biophysical research communications 1980;95(1):482-9.
1980: John I Clark; George B. Benedek
The effects of glycols, aldehydes, and acrylamide on phase separation and opacification in the calf lens.
Investigative ophthalmology & visual science 1980;19(7):771-6.