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Richard Clark

Research Profile

Chemicals & Drugs

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Protein Folding

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Nuclear Magnetic Resonance, Biomolecular

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Publications

TOP 3
Richard J Clark; Norelle L Daly; Quentin Kaas; Muharrem Akcan; David J Craik
Cyclization of conotoxins to improve their biopharmaceutical properties.
Reena Halai; Norelle L Daly; David J Adams; Brid P Callaghan; Richard J Clark; David J Craik
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.
Conan K L Wang; Richard J Clark; Peta J Harvey; Masa Cemazar; Johan Rosengren; David J Craik
The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant.

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All Publications

2012: Richard J Clark; Norelle L Daly; Quentin Kaas; Muharrem Akcan; David J Craik
Cyclization of conotoxins to improve their biopharmaceutical properties.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):446-55.
2011: Reena Halai; Norelle L Daly; David J Adams; Brid P Callaghan; Richard J Clark; David J Craik
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.
Journal of medicinal chemistry 2011;54(19):6984-92.
2011: Conan K L Wang; Richard J Clark; Peta J Harvey; Masa Cemazar; Johan Rosengren; David J Craik
The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant.
Biochemistry 2011;50(19):4077-86.
2011: Richard J Clark; Chia Chia Tan; Gloria C Preza; Elizabeta Nemeth; Tomas Ganz; David J Craik
Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.
Chemistry & biology 2011;18(3):336-43.
2011: Muharrem Akcan; Richard J Clark; David J Craik; Norelle L Daly; Stacey J Hansen; Mark R Stroud; James M Olson
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.
Journal of medicinal chemistry 2011;54(3):782-7.
2011: Erica Lovelace; Sunithi Gunasekera; Charlotta Alvarmo; Richard J Clark; Simon T Nevin; Anton A Grishin; David J Adams; David J Craik; Norelle L Daly
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization.
Antioxidants & redox signaling 2011;14(1):87-95.
2011: Teshome Leta Aboye; Richard J Clark; Robert Burman; Marta Bajona Roig; David J Craik; Ulf Göransson
Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides.
Antioxidants & redox signaling 2011;14(1):77-86.
2010: Sónia Troeira Henriques; Chia Chia Tan; David J Craik; Richard J Clark
Structural and functional analysis of human liver-expressed antimicrobial peptide 2.
Chembiochem : a European journal of chemical biology 2010;11(15):2148-57.
2010: David C Ireland; Richard J Clark; Norelle L Daly; David J Craik
Isolation, sequencing, and structure-activity relationships of cyclotides.
Journal of natural products 2010;73(9):1610-22.
2010: Richard J Clark; Jonas Jensen; Simon T Nevin; Brid P Callaghan; David J Adams; David J Craik
The engineering of an orally active conotoxin for the treatment of neuropathic pain.
Angewandte Chemie (International ed. in English) 2010;49(37):6545-8.
2010: Yen-Hua Huang; Michelle Colgrave; Richard J Clark; Andrew C Kotze; David J Craik
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity.
The Journal of biological chemistry 2010;285(14):10797-805.
2010: Richard J Clark; David J Craik
Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins.
Biopolymers 2010;94(4):414-22.
2010: Robert Burman; Erika Svedlund; Jenny Felth; Saadia Hassan; Anders Herrmann; Richard J Clark; David J Craik; Lars Bohlin; Per Claeson; Ulf Göransson; Joachim Gullbo
Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice.
Biopolymers 2010;94(5):626-34.
2009: Jane E Lattin; Kathryn P Greenwood; Norelle L Daly; Gregory Kelly; David A Zidar; Richard J Clark; Walter G Thomas; Stuart Kellie; David J Craik; David A Hume; Matthew J Sweet
Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival.
Molecular immunology 2009;47(2-3):340-7.
2009: Sunithi Gunasekera; Norelle L Daly; Richard J Clark; David J Craik
Dissecting the oxidative folding of circular cystine knot miniproteins.
Antioxidants & redox signaling 2009;11(5):971-80.
2009: Emma L Millard; Simon T Nevin; Marion L Loughnan; Annette Nicke; Richard J Clark; Paul F Alewood; Richard J Lewis; David J Adams; David J Craik; Norelle L Daly
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues.
The Journal of biological chemistry 2009;284(8):4944-51.
2008: Brid Callaghan; Alison Haythornthwaite; Géza Berecki; Richard J Clark; David J Craik; David J Adams
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(43):10943-51.
2008: Richard J Clark; Norelle L Daly; Reena Halai; Simon T Nevin; David J Adams; David J Craik
The three-dimensional structure of the analgesic alpha-conotoxin, RgIA.
FEBS letters 2008;582(5):597-602.
2008: Anders Herrmann; Robert Burman; Joshua S Mylne; Gustav Karlsson; Joachim Gullbo; David J Craik; Richard J Clark; Ulf Göransson
The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity.
Phytochemistry 2008;69(4):939-52.
2008: Teshome Leta Aboye; Richard J Clark; David J Craik; Ulf Göransson
Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2.
Chembiochem : a European journal of chemical biology 2008;9(1):103-13.
2008: Jan-Christoph Westermann; Richard J Clark; David J Craik
Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR.
Protein and peptide letters 2008;15(9):910-4.
2007: Simon T Nevin; Richard J Clark; H Klimis; MacDonald J Christie; David J Craik; David J Adams
Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?
Molecular pharmacology 2007;72(6):1406-10.
2007: Christian W Gruber; maja cemazar; Richard J Clark; Tomohisa Horibe; Rosemary F Renda; Marilyn A Anderson; David J Craik
A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins.
The Journal of biological chemistry 2007;282(28):20435-46.
2007: Manuel R Plan; Ulf Göransson; Richard J Clark; Norelle L Daly; Michelle Colgrave; David J Craik
The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.
Chembiochem : a European journal of chemical biology 2007;8(9):1001-11.
2007: David J Craik; Richard J Clark; Norelle L Daly
Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins.
Expert opinion on investigational drugs 2007;16(5):595-604.
2007: Ai-Hua Jin; Hemma Brandstaetter; Simon T Nevin; Chia Chia Tan; Richard J Clark; David J Adams; Paul F Alewood; David J Craik; Norelle L Daly
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics.
BMC structural biology 2007;7():28.
2006: Norelle L Daly; Yi-Kuang Chen; Fiona M Foley; Paramjit S Bansal; Rekha Bharathi; Richard J Clark; Christian P Sommerhoff; David J Craik
The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold.
The Journal of biological chemistry 2006;281(33):23668-75.
2006: Richard J Clark; Harald Fischer; Simon T Nevin; David J Adams; David J Craik
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.
The Journal of biological chemistry 2006;281(32):23254-63.
2006: Richard J Clark; Norelle L Daly; David J Craik
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.
The Biochemical journal 2006;394(Pt 1):85-93.
2006: Norelle L Daly; Richard J Clark; Manuel R Plan; David J Craik
Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.
The Biochemical journal 2006;393(Pt 3):619-26.
2005: Richard J Clark; Harald Fischer; Louise Dempster; Norelle L Daly; Johan Rosengren; Simon T Nevin; Frederic A Meunier; David J Adams; David J Craik
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13767-72.
2005: Michael L J Korsinczky; Richard J Clark; David J Craik
Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1.
Biochemistry 2005;44(4):1145-53.
2004: Julie L Dutton; Rosemary F Renda; Clement Waine; Richard J Clark; Norelle L Daly; Cameron V Jennings; Marilyn A Anderson; David J Craik
Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins.
The Journal of biological chemistry 2004;279(45):46858-67.
2003: Johan Rosengren; Richard J Clark; Norelle L Daly; Ulf Göransson; Alun Jones; David J Craik
Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.
Journal of the American Chemical Society 2003;125(41):12464-74.
2003: Daniel G Barry; Norelle L Daly; Richard J Clark; Lillian Sando; David J Craik
Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity.
Biochemistry 2003;42(22):6688-95.
2003: Norelle L Daly; Richard J Clark; David J Craik
Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides.
The Journal of biological chemistry 2003;278(8):6314-22.