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Robert Clark

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Dennis W Simon; Giulio Zuccoli; Yong Sing Da Silva; Robert S B Clark
Acute encephalitis.
Patrick M Kochanek; C Edward Dixon; Ericka L Fink; Alicia K Au; Hülya Bayır; Michael J Bell; Rachel Pardes Berger; Robert S B Clark
The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care.
E Su; Elizabeth C Tyler-Kabara; Stephen R Wisniewski; H Bayir; P David Adelson; Michael J Bell; Robert S B Clark; Keri L Janesko-Feldman; Patrick M Kochanek; Rachel Pardes Berger
Increased CSF concentrations of myelin basic protein after TBI in infants and children: absence of significant effect of therapeutic hypothermia.

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All Publications

2013: Dennis W Simon; Giulio Zuccoli; Yong Sing Da Silva; Robert S B Clark
Acute encephalitis.
Critical care clinics 2013;29(2):259-77.
2013: Patrick M Kochanek; C Edward Dixon; Ericka L Fink; Alicia K Au; Hülya Bayır; Michael J Bell; Rachel Pardes Berger; Robert S B Clark
The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care.
Frontiers in neurology 2013;4():40.
2012: E Su; Elizabeth C Tyler-Kabara; Stephen R Wisniewski; H Bayir; P David Adelson; Michael J Bell; Robert S B Clark; Keri L Janesko-Feldman; Patrick M Kochanek; Rachel Pardes Berger
Increased CSF concentrations of myelin basic protein after TBI in infants and children: absence of significant effect of therapeutic hypothermia.
Neurocritical care 2012;17(3):401-7.
2012: Hao Liu; Mioara D Manole; Marie Rose; Syana M Sarnaik; Sunita N Shinde; Henry Alexander; Jie Chen; Yaming Chen; Robert S B Clark; Steven H Graham; Wenjin Li; Robert W Hickey
Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival.
Resuscitation 2012;83(12):1491-6.
2012: Jing Ji; Valerian E Kagan; Anthony E Kline; Patrick M Kochanek; Mioara D Manole; David O Okonkwo; Ava M Puccio; Alejandro K Samhan-Arias; Louis J Sparvero; Vladimir A Tyurin; Yulia Y Tyurina; Peter Wipf; Henry Alexander; Andrew A Amoscato; Jeffrey P Cheng; Robert S B Clark; Bruno Fink; Hülya Bayır
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury.
Nature neuroscience 2012;15(10):1407-13.
2012: Joseph N Hemerka; Keri L Janesko-Feldman; Larry W Jenkins; Hülya Bayır; Brian Blasiole; Robert S B Clark; C Edward Dixon; Jennifer L Exo; Robert H Garman; David K Shellington; Samuel A Tisherman; Vincent A Vagni; Stephen R Wisniewski; Xianren Wu; Mu Xu; Patrick M Kochanek
Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice.
Journal of neurotrauma 2012;29(12):2192-208.
2012: Alicia K Au; Hülya Bayir; Michael J Bell; P David Adelson; Rajesh K Aneja; Keri Feldman; Ericka L Fink; Patrick M Kochanek; Robert S B Clark
Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury.
Journal of neurotrauma 2012;29(11):2013-21.
2012: Michael Shoykhet; Daniel J Simons; Henry Alexander; Christina Hosler; Patrick M Kochanek; Robert S B Clark
Thalamocortical dysfunction and thalamic injury after asphyxial cardiac arrest in developing rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(14):4972-81.
2012: Jing Ji; Valerian E Kagan; Patrick M Kochanek; David F Meaney; Donna B Stolz; Minke Tang; Yulia Y Tyurina; Robert S B Clark; Weihong Feng; Hülya Bayır
Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids.
Journal of neurotrauma 2012;29(5):776-88.
2012: Mioara D Manole; Henry Alexander; Hülya Bayır; Lesley M Foley; Robert Garman; T Kevin Hitchens; Chien Ho; Carleton J C Hsia; Patrick M Kochanek; Li Ma; Robert S B Clark
Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(3):560-9.
2011: Amy K Wagner; Krutika B Amin; Hülya Bayir; Robert S B Clark; C Edward Dixon; Patrick M Kochanek; Emily H McCullough; Christian Niyonkuru; H Ozawa; Brett A Postal; Anthony Fabio
CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(9):1886-96.
2011: Alicia K Au; Joseph A Carcillo; Robert S B Clark; Michael J Bell
Brain injuries and neurological system failure are the most common proximate causes of death in children admitted to a pediatric intensive care unit.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2011;12(5):566-71.
2011: Jennifer Exo; Stephanie Greene; Patrick M Kochanek; Stephen R Wisniewski; P David Adelson; Hülya Bayir; Robert S B Clark; Michael J Bell
Intracranial pressure-monitoring systems in children with traumatic brain injury: combining therapeutic and diagnostic tools.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2011;12(5):560-5.
2011: Craig M Smith; Yaming Chen; Mara L Sullivan; Patrick M Kochanek; Robert S B Clark
Autophagy in acute brain injury: feast, famine, or folly?
Neurobiology of disease 2011;43(1):52-9.
2011: Craig M Smith; P David Adelson; Hülya Bayir; S Danielle Brown; Yue-Fang Chang; Robert S B Clark; Jessica Hinchberger; Patrick M Kochanek; Michael J Bell
Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2011;12(4):449-54.
2011: Robert H Garman; Edwin K Jackson; Larry W Jenkins; Valerian Kagan; Steven A Parks; David V Ritzel; Peter V Swauger; Robert C Switzer; Lawrence C Tong; Hülya Bayir; Richard A Bauman; Robert S B Clark; C Edward Dixon; Patrick M Kochanek
Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury.
Journal of neurotrauma 2011;28(6):947-59.
2011: David K Shellington; Lina Du; Xianren Wu; Jennifer Exo; Vincent A Vagni; Li Ma; Keri L Janesko-Feldman; Robert S B Clark; Hülya Bayir; C Edward Dixon; Larry W Jenkins; Carleton J C Hsia; Patrick M Kochanek
Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice.
Critical care medicine 2011;39(3):494-505.
2011: Karen H Walson; Minke Tang; Ashley Glumac; Henry Alexander; Mioara D Manole; Li Ma; Carleton J C Hsia; Robert S B Clark; Patrick M Kochanek; Valerian E Kagan; Hülya Bayr
Normoxic versus hyperoxic resuscitation in pediatric asphyxial cardiac arrest: effects on oxidative stress.
Critical care medicine 2011;39(2):335-43.
2011: Yi-Chen Lai; Margaret A Satchell; Rajesh K Aneja; Robert S B Clark
Detecting and quantifying pADPr in vivo.
Methods in molecular biology (Clifton, N.J.) 2011;780():117-34.
2011: Frank W Moler; Amy E Donaldson; Kathleen L Meert; Richard J Brilli; Vinay Nadkarni; Donald H Shaffner; Charles L Schleien; Robert S B Clark; Heidi J Dalton; Kimberly Statler; Kelly S Tieves; Richard Hackbarth; Robert K Pretzlaff; Elise W van der Jagt; Jose Pineda; Lynn Hernan; J Michael Dean
Multicenter cohort study of out-of-hospital pediatric cardiac arrest.
Critical care medicine 2011;39(1):141-9.
2010: Rosanne Salonia; Philip E Empey; Samuel M Poloyac; Stephen R Wisniewski; Megan Klamerus; H Ozawa; Amy K Wagner; Randall A Ruppel; Michael J Bell; Keri Feldman; P David Adelson; Robert S B Clark; Patrick M Kochanek
Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury.
Journal of neurotrauma 2010;27(10):1819-25.
2010: Alicia K Au; Hülya Bayir; Patrick M Kochanek; Robert S B Clark
Evaluation of autophagy using mouse models of brain injury.
Biochimica et biophysica acta 2010;1802(10):918-23.
2010: Ericka L Fink; Patrick M Kochanek; Robert S B Clark; Michael J Bell
How I cool children in neurocritical care.
Neurocritical care 2010;12(3):414-20.
2010: Ajit A Sarnaik; Yvette P Conley; David O Okonkwo; Taura L Barr; Ericka L Fink; Csaba Szabó; Patrick M Kochanek; Robert S B Clark
Influence of PARP-1 polymorphisms in patients after traumatic brain injury.
Journal of neurotrauma 2010;27(3):465-71.
2010: Erik Su; Michael J Bell; Stephen R Wisniewski; P David Adelson; Keri L Janesko-Feldman; Rosanne Salonia; Robert S B Clark; Patrick M Kochanek; Valerian E Kagan; Hülya Bayır
α-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia.
Developmental neuroscience 2010;32(5-6):385-95.
2010: Amit Mehta; Patrick M Kochanek; Elizabeth Tyler-Kabara; P David Adelson; Stephen R Wisniewski; Rachel Pardes Berger; Maria D Sidoni; Rachelle L Bell; Robert S B Clark; Michael J Bell
Relationship of intracranial pressure and cerebral perfusion pressure with outcome in young children after severe traumatic brain injury.
Developmental neuroscience 2010;32(5-6):413-9.
2010: Jerry Nolan; Robert W Neumar; Christophe Adrie; Mayuki Aibiki; Robert A Berg; Bernd W Bbttiger; Clifton Callaway; Robert S B Clark; Romergryko G Geocadin; Edward Jauch; Karl B Kern; Ivan Laurent; W T Longstreth; Raina M Merchant; Peter Morley; Laurie J Morrison; Vinay Nadkarni; Mary Ann Peberdy; Emanuel P Rivers; Antonio Rodriguez-Nunez; Frank W Sellke; Christian Spaulding; Kjetil Sunde; Terry Vanden Hoek
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication: a scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke (Part II).
International emergency nursing 2010;18(1):8-28.
2010: Ericka L Fink; Robert S B Clark; Patrick M Kochanek; Michael J Bell; R Scott Watson
A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2010;11(1):66-74.
2010: Minke Tang; Henry Alexander; Robert S B Clark; Patrick M Kochanek; Valerian E Kagan; Hülya Bayir
Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(1):119-29.
2009: Mioara D Manole; Patrick M Kochanek; Ericka L Fink; Robert S B Clark
Postcardiac arrest syndrome: focus on the brain.
Current opinion in pediatrics 2009;21(6):745-50.
2009: Jennifer L Exo; David K Shellington; Hülya Bayir; Vincent A Vagni; Keri Janesco-Feldman; Lil Ma; Carleton J Hsia; Robert S B Clark; Larry W Jenkins; C Edward Dixon; Patrick M Kochanek
Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice.
Journal of neurotrauma 2009;26(12):2403-8.
2009: Joan Sanchez de Toledo; P David Adelson; R Scott Watson; Barbara A Gaines; S Danielle Brown; Patrick M Kochanek; Stephen R Wisniewski; Ericka Fink; Hülya Bayir; Robert S B Clark; Michael J Bell
Relationship between increases in pancreatic enzymes and cerebral events in children after traumatic brain injury.
Neurocritical care 2009;11(3):322-9.
2009: Jerry Nolan; Robert W Neumar; Christophe Adrie; Mayuki Aibiki; Robert A Berg; Bernd W Bbttiger; Clifton Callaway; Robert S B Clark; Romergryko G Geocadin; Edward Jauch; Karl B Kern; Ivan Laurent; W T Longstreth; Raina M Merchant; Peter Morley; Laurie J Morrison; Vinay Nadkarni; Mary Ann Peberdy; Emanuel P Rivers; Antonio Rodriguez-Nunez; Frank W Sellke; Christian Spaulding; Kjetil Sunde; Terry Vanden Hoek
Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke (Part 1).
International emergency nursing 2009;17(4):203-25.
2009: Kathleen L Meert; Amy Donaldson; Vinay M Nadkarni; Kelly S Tieves; Charles L Schleien; Richard J Brilli; Robert S B Clark; Donald H Shaffner; Fiona Levy; Kimberly Statler; Heidi J Dalton; Elise W van der Jagt; Richard Hackbarth; Robert K Pretzlaff; Lynn Hernan; J Michael Dean; Frank W Moler
Multicenter cohort study of in-hospital pediatric cardiac arrest.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2009;10(5):544-53.
2009: Frank W Moler; Kathleen L Meert; Amy E Donaldson; Vinay Nadkarni; Richard J Brilli; Heidi J Dalton; Robert S B Clark; Donald H Shaffner; Charles L Schleien; Kimberly Statler; Kelly S Tieves; Richard Hackbarth; Robert K Pretzlaff; Elise W van der Jagt; Fiona Levy; Lynn Hernan; Faye S Silverstein; J Michael Dean
In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study.
Critical care medicine 2009;37(7):2259-67.
2009: Alia Marie Dennis; M Lee Haselkorn; Vincent A Vagni; Robert H Garman; Keri Janesko-Feldman; Hülya Bayir; Robert S B Clark; Larry W Jenkins; C Edward Dixon; Patrick M Kochanek
Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.
Journal of neurotrauma 2009;26(6):889-99.
2009: Patrick M Kochanek; Ericka L Fink; Michael J Bell; Hülya Bayir; Robert S B Clark
Therapeutic hypothermia: applications in pediatric cardiac arrest.
Journal of neurotrauma 2009;26(3):421-7.
2009: Lina Du; Robert W Hickey; Hülya Bayir; simon simon watkins; Vladimir A Tyurin; Fengli Guo; Patrick M Kochanek; Larry W Jenkins; Jin Ren; Greg Gibson; Charleen T Chu; Valerian E Kagan; Robert S B Clark
Starving neurons show sex difference in autophagy.
The Journal of biological chemistry 2009;284(4):2383-96.
2009: Charleen T Chu; Edward D Plowey; Ruben K Dagda; Robert W Hickey; Salvatore J Cherra; Robert S B Clark
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models.
Methods in enzymology 2009;453():217-49.
2009: Mioara D Manole; Lesley M Foley; T Kevin Hitchens; Patrick M Kochanek; Robert W Hickey; Hülya Bayir; Henry Alexander; Chien Ho; Robert S B Clark
Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(1):197-205.
2008: Robert W Neumar; Jerry Nolan; Christophe Adrie; Mayuki Aibiki; Robert A Berg; Bernd W Böttiger; Clifton Callaway; Robert S B Clark; Romergryko G Geocadin; Edward Jauch; Karl B Kern; Ivan Laurent; W T Longstreth; Raina M Merchant; Peter Morley; Laurie J Morrison; Vinay Nadkarni; Mary Ann Peberdy; Emanuel P Rivers; Antonio Rodriguez-Nunez; Frank W Sellke; Christian Spaulding; Kjetil Sunde; Terry Vanden Hoek
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council.
Circulation 2008;118(23):2452-83.
2008: Jerry Nolan; Robert W Neumar; Christophe Adrie; Mayuki Aibiki; Robert A Berg; Bernd W Böttiger; Clifton Callaway; Robert S B Clark; Romergryko G Geocadin; Edward Jauch; Karl B Kern; Ivan Laurent; W T Longstreth; Raina M Merchant; Peter Morley; Laurie J Morrison; Vinay Nadkarni; Mary Ann Peberdy; Emanuel P Rivers; Antonio Rodriguez-Nunez; Frank W Sellke; Christian Spaulding; Kjetil Sunde; Terry Vanden Hoek
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke.
Resuscitation 2008;79(3):350-79.
2008: Fei Han; Tomas Drabek; Jason Stezoski; Keri Janesko-Feldman; S William Stezoski; Robert S B Clark; Hülya Bayir; Samuel A Tisherman; Patrick M Kochanek
Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.
Resuscitation 2008;79(2):301-10.
2008: Ajit A Sarnaik; Yvette P Conley; Robert S B Clark
Susceptibility to meningococcal infection--nature versus nurture?
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2008;9(5):540-2.
2008: Ericka L Fink; Yichen Lai; Xiaopeng Zhang; Keri L Janesko-Feldman; P David Adelson; Csaba Szabó; Rachel Pardes Berger; Ajit A Sarnaik; Patrick M Kochanek; Robert S B Clark
Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(9):1523-9.
2008: Roya Tehranian; Marie E Rose; Vincent A Vagni; Alicia M Pickrell; Raymond P Griffith; Hao Liu; Robert S B Clark; C Edward Dixon; Patrick M Kochanek; Steven H Graham
Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury.
Journal of neurotrauma 2008;25(7):755-67.
2008: Mioara D Manole; Robert W Hickey; Robert S B Clark; Patrick M Kochanek
Current and future therapies of pediatric cardiopulmonary arrest.
Indian journal of pediatrics 2008;75(6):609-14.
2008: Patrick M Kochanek; Rachel Pardes Berger; Hülya Bayir; Amy K Wagner; Larry W Jenkins; Robert S B Clark
Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making.
Current opinion in critical care 2008;14(2):135-41.
2008: Yichen Lai; Yaming Chen; simon simon watkins; Paula D Nathaniel; Fengli Guo; Patrick M Kochanek; Larry W Jenkins; Csaba Szabó; Robert S B Clark
Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.
Journal of neurochemistry 2008;104(6):1700-11.
2008: Yichen Lai; Robert W Hickey; Yaming Chen; Hülya Bayir; Mara L Sullivan; Charleen T Chu; Patrick M Kochanek; C Edward Dixon; Larry W Jenkins; Steven H Graham; simon simon watkins; Robert S B Clark
Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):540-50.
2008: Kathleen T Sachse; Edwin K Jackson; Stephen R Wisniewski; Delbert G Gillespie; Ava M Puccio; Robert S B Clark; C Edward Dixon; Patrick M Kochanek
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):395-401.
2008: Robert S B Clark; Hülya Bayir; Charleen T Chu; Sean M Alber; Patrick M Kochanek; simon simon watkins
Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness.
Autophagy 2008;4(1):88-90.
2007: Sandra D W Buttram; Stephen R Wisniewski; Edwin K Jackson; P David Adelson; Keri Feldman; Hülya Bayir; Rachel Pardes Berger; Robert S B Clark; Patrick M Kochanek
Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia.
Journal of neurotrauma 2007;24(11):1707-17.
2007: Guodong Cao; Juan Xing; Xiao Xiao; Anthony K F Liou; Yanqin Gao; Xiao-Ming Yin; Robert S B Clark; Steven H Graham; Jun Chen
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9278-93.
2007: Robert S B Clark; Vincent A Vagni; Paula D Nathaniel; Larry W Jenkins; C Edward Dixon; Csaba Szabó
Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.
Journal of neurotrauma 2007;24(8):1399-405.
2007: Hülya Bayir; Vladimir A Tyurin; Yulia Y Tyurina; Rosa Viner; Vladimir B Ritov; Andrew A Amoscato; Qing Zhao; Xiaojing J Zhang; Keri L Janesko-Feldman; Henry Alexander; Liana V Basova; Robert S B Clark; Patrick M Kochanek; Valerian E Kagan
Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis.
Annals of neurology 2007;62(2):154-69.
2007: Steven T DeKosky; Eric Abrahamson; John R Ciallella; William R Paljug; Stephen R Wisniewski; Robert S B Clark; Milos D Ikonomovic
Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans.
Archives of neurology 2007;64(4):541-4.
2007: Hülya Bayir; Valerian E Kagan; Robert S B Clark; Keri L Janesko-Feldman; Ruslan Rafikov; Zhentai Huang; Xiaojing Zhang; Vincent A Vagni; Timothy R Billiar; Patrick M Kochanek
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Journal of neurochemistry 2007;101(1):168-81.
2007: Robert S B Clark; Paula D Nathaniel; Xiaopeng Zhang; C Edward Dixon; Sean Alber; simon simon watkins; John A Melick; Patrick M Kochanek; Steven H Graham
boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(2):316-26.
2007: Paul M Shore; Rachel P Berger; Sumeeta Varma; Keri L Janesko; Stephen R Wisniewski; Robert S B Clark; P David Adelson; Neal J Thomas; Yi-Chen Lai; Hülya Bayir; Patrick M Kochanek
Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury.
Journal of neurotrauma 2007;24(1):75-86.
2007: Wei-Min Gao; Mandeep S Chadha; Rachel Pardes Berger; Gilbert S Omenn; David L Allen; Michael Pisano; P David Adelson; Robert S B Clark; Larry W Jenkins; Patrick M Kochanek
A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury.
Journal of neurotrauma 2007;24(1):43-53.
2006: Xiaopeng Zhang; Sean Alber; simon simon watkins; Patrick M Kochanek; Donald W Marion; Steven H Graham; Robert S B Clark
Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.
Journal of neurotrauma 2006;23(11):1583-90.
2006: Mioara D Manole; Robert W Hickey; Nobuo Momoi; Kimimasa Tobita; Joseph P Tinney; Gabriel P Suciu; Michael J Johnnides; Robert S B Clark; Bradley B Keller
Preterminal gasping during hypoxic cardiac arrest increases cardiac function in immature rats.
Pediatric research 2006;60(2):174-9.
2006: Roya Tehranian; Marie E Rose; Vincent A Vagni; R P Griffith; Shasha Wu; Sara Maits; Xiaopeng Zhang; Robert S B Clark; C Edward Dixon; Patrick M Kochanek; Ora Bernard; Steven H Graham
Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury.
Brain research 2006;1101(1):126-35.
2006: Xiaopeng Zhang; Yaming Chen; Milos D Ikonomovic; Paula D Nathaniel; Patrick M Kochanek; Donald W Marion; Steven T DeKosky; Larry W Jenkins; Robert S B Clark
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(7):915-26.
2006: Patrick M Kochanek; Vincent A Vagni; Keri L Janesko; Christopher B Washington; Patricia K Crumrine; Robert H Garman; Larry W Jenkins; Robert S B Clark; Gregg E Homanics; C Edward Dixon; Jurgen Schnermann; Edwin K Jackson
Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(4):565-75.
2006: Kimberly D Statler; Henry Alexander; Vincent A Vagni; Richard Holubkov; C Edward Dixon; Robert S B Clark; Larry Jenkins; Patrick M Kochanek
Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury.
Brain research 2006;1076(1):216-24.
2006: Eric Abrahamson; Milos D Ikonomovic; John R Ciallella; Caroline E Hope; William R Paljug; Barbara A Isanski; Dorothy G Flood; Robert S B Clark; Steven T DeKosky
Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.
Experimental neurology 2006;197(2):437-50.
2006: Wei-Min Gao; Mandeep S Chadha; Anthony E Kline; Robert S B Clark; Patrick M Kochanek; C Edward Dixon; Larry W Jenkins
Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats.
Brain research 2006;1070(1):31-4.
2006: Ashley R Kochanek; Anthony E Kline; Wei-Min Gao; Mandeep S Chadha; Yichen Lai; Robert S B Clark; C Edward Dixon; Larry W Jenkins
Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact.
Developmental neuroscience 2006;28(4-5):410-9.
2006: J'mir L Cousar; Yichen Lai; Christina D Marco; Hülya Bayir; P David Adelson; Keri L Janesko-Feldman; Patrick M Kochanek; Robert S B Clark
Heme oxygenase 1 in cerebrospinal fluid from infants and children after severe traumatic brain injury.
Developmental neuroscience 2006;28(4-5):342-7.
2006: Yichen Lai; Christopher Stange; Stephen R Wisniewski; P David Adelson; Keri L Janesko-Feldman; Danielle S Brown; Patrick M Kochanek; Robert S B Clark
Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury.
Developmental neuroscience 2006;28(4-5):336-41.
2006: Kimberly D Statler; Henry Alexander; Vincent A Vagni; C Edward Dixon; Robert S B Clark; Larry Jenkins; Patrick M Kochanek
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Journal of neurotrauma 2006;23(1):97-108.
2006: Patrick M Kochanek; Robert S B Clark; Kimberly D Statler; Larry W Jenkins
Physiological assessment and control in studies evaluating central nervous system injury: should size matter?
Anesthesia and analgesia 2006;102(1):72-4.
2005: Yichen Lai; Keri L Feldman; Robert S B Clark
Enzyme-linked immunosorbent assays (ELISAs).
Critical care medicine 2005;33(12 Suppl):S433-4.
2005: Robert S B Clark; Hülya Bayir; Larry W Jenkins
Posttranslational protein modifications.
Critical care medicine 2005;33(12 Suppl):S407-9.
2005: Yong Y Han; Joseph A Carcillo; Shekhar T Venkataraman; Robert S B Clark; R Scott Watson; Trung C Nguyen; Hülya Bayir; Richard A Orr
Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system.
Pediatrics 2005;116(6):1506-12.
2005: Yichen Lai; Lina Du; Katherine E Dunsmore; Larry W Jenkins; Hector R Wong; Robert S B Clark
Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity.
Journal of neurochemistry 2005;94(2):360-6.
2005: Margaret A Satchell; Yichen Lai; Patrick M Kochanek; Stephen R Wisniewski; Ericka L Fink; Neal A Siedberg; Rachel Pardes Berger; Steven T DeKosky; P David Adelson; Robert S B Clark
Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(7):919-27.
2005: Kate A Felmet; Mark W Hall; Robert S B Clark; Ronald Jaffe; Joseph A Carcillo
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3765-72.
2005: Ericka L Fink; Christina D Marco; Holly A Donovan; Henry Alexander; C Edward Dixon; Larry W Jenkins; Christopher J Stange; Patrick M Kochanek; Robert S B Clark
Brief induced hypothermia improves outcome after asphyxial cardiopulmonary arrest in juvenile rats.
Developmental neuroscience 2005;27(2-4):191-9.
2005: Xiaopeng Zhang; Yaming Chen; Larry W Jenkins; Patrick M Kochanek; Robert S B Clark
Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury.
Critical care (London, England) 2005;9(1):66-75.
2004: Milos D Ikonomovic; Kunihiro Uryu; Eric Abrahamson; John R Ciallella; John Q Trojanowski; Virginia M-Y Lee; Robert S B Clark; Donald W Marion; Stephen R Wisniewski; Steven T DeKosky
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.
Experimental neurology 2004;190(1):192-203.
2004: Lina Du; Hülya Bayir; Yichen Lai; Xiaopeng Zhang; Patrick M Kochanek; simon simon watkins; Steven H Graham; Robert S B Clark
Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway.
The Journal of biological chemistry 2004;279(37):38563-70.
2004: Paul M Shore; Neal J Thomas; Robert S B Clark; P David Adelson; Stephen R Wisniewski; Keri L Janesko; Hülya Bayir; Edwin K Jackson; Patrick M Kochanek
Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers.
Journal of neurotrauma 2004;21(9):1113-22.
2004: Yichen Lai; Patrick M Kochanek; P David Adelson; Keri L Janesko; Randall A Ruppel; Robert S B Clark
Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.
Journal of neurotrauma 2004;21(3):229-37.
2004: Ericka L Fink; Robert S B Clark
Don't forget the "single chromosome polymorphism": a need for gender-stratification in pediatric patients?
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004;5(2):193-4.
2004: Paul M Shore; Edwin K Jackson; Stephen R Wisniewski; Robert S B Clark; P David Adelson; Patrick M Kochanek
Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and children.
Neurosurgery 2004;54(3):605-11; discussion 611-2.
2004: Ericka L Fink; Henry Alexander; Christina D Marco; C Edward Dixon; Patrick M Kochanek; Larry W Jenkins; Yichen Lai; Holly A Donovan; Robert W Hickey; Robert S B Clark
Experimental model of pediatric asphyxial cardiopulmonary arrest in rats.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004;5(2):139-44.
2004: Hülya Bayir; Donald W Marion; Ava M Puccio; Stephen R Wisniewski; Keri L Janesko; Robert S B Clark; Patrick M Kochanek
Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients.
Journal of neurotrauma 2004;21(1):1-8.
2003: Kimberly D Statler; Keri L Janesko; John A Melick; Robert S B Clark; Larry W Jenkins; Patrick M Kochanek
Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats.
Brain research 2003;994(1):37-43.
2003: Guodong Cao; Robert S B Clark; Wei Pei; Wei Yin; Feng Zhang; Feng-Yan Sun; Steven H Graham; Jun Chen
Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(10):1137-50.
2003: Hülya Bayir; Patrick M Kochanek; Robert S B Clark
Traumatic brain injury in infants and children: mechanisms of secondary damage and treatment in the intensive care unit.
Critical care clinics 2003;19(3):529-49.
2003: Xiaopeng Zhang; Steven H Graham; Patrick M Kochanek; Donald W Marion; Paula D Nathaniel; simon simon watkins; Robert S B Clark
Caspase-8 expression and proteolysis in human brain after severe head injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1367-9.
2003: Lina Du; Xiaopeng Zhang; Yong Y Han; Nancy A Burke; Patrick M Kochanek; simon simon watkins; Steven H Graham; Joseph A Carcillo; Csaba Szabó; Robert S B Clark
Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress.
The Journal of biological chemistry 2003;278(20):18426-33.
2003: Margaret A Satchell; Xiaopeng Zhang; Patrick M Kochanek; C Edward Dixon; Larry W Jenkins; John A Melick; Csaba Szabó; Robert S B Clark
A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma.
Journal of neurochemistry 2003;85(3):697-708.
2003: Anthony K F Liou; Robert S B Clark; David C Henshall; Xiao-Ming Yin; Jun Chen
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways.
Progress in neurobiology 2003;69(2):103-42.
2003: Neal A Seidberg; Robert S B Clark; Xiaopeng Zhang; Yichen Lai; Minzhi Chen; Steven H Graham; Patrick M Kochanek; simon simon watkins; Donald W Marion
Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury.
Journal of neurochemistry 2003;84(3):514-21.
2003: Hülya Bayir; Robert S B Clark; Patrick M Kochanek
Promising strategies to minimize secondary brain injury after head trauma.
Critical care medicine 2003;31(1 Suppl):S112-7.
2002: Lesley A Doughty; Robert S B Clark; Sandra S Kaplan; Howell Sasser; Joseph A Carcillo
sFas and sFas ligand and pediatric sepsis-induced multiple organ failure syndrome.
Pediatric research 2002;52(6):922-7.
2002: Manu R Varma; C Edward Dixon; Edwin K Jackson; Grant W Peters; John A Melick; Raymond P Griffith; Vincent A Vagni; Robert S B Clark; Larry W Jenkins; Patrick M Kochanek
Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology.
Brain research 2002;951(2):191-201.
2002: Robert S B Clark
Out of the frying pan and into the fire: neurodevelopmental outcome in pediatric intensive care unit survivors of serious brain injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2002;3(4):384-5.
2002: Xiaopeng Zhang; Jun Chen; Steven H Graham; Lina Du; Patrick M Kochanek; Romesh A Draviam; Fengli Guo; Paula D Nathaniel; Csaba Szabó; simon simon watkins; Robert S B Clark
Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite.
Journal of neurochemistry 2002;82(1):181-91.
2002: Hülya Bayir; Valerian E Kagan; Yulia Y Tyurina; Vladimir A Tyurin; Randall A Ruppel; P David Adelson; Steven H Graham; Keri L Janesko; Robert S B Clark; Patrick M Kochanek
Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children.
Pediatric research 2002;51(5):571-8.
2002: Randall A Ruppel; Robert S B Clark; Hülya Bayir; Margaret A Satchell; Patrick M Kochanek
Critical mechanisms of secondary damage after inflicted head injury in infants and children.
Neurosurgery clinics of North America 2002;13(2):169-82, v.
2002: Rachel Pardes Berger; Mary Clyde Pierce; Stephen R Wisniewski; P David Adelson; Robert S B Clark; Randall A Ruppel; Patrick M Kochanek
Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children.
Pediatrics 2002;109(2):E31.
2002: Wilhelm Behringer; Peter Safar; Rainer Kentner; Xianren Wu; Valerian E Kagan; Ann Radovsky; Robert S B Clark; Patrick M Kochanek; Murugan Subramanian; Vladimir A Tyurin; Yulia Y Tyurina; Samuel A Tisherman
Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):105-17.
2001: Courtney L Robertson; Michael J Bell; Patrick M Kochanek; P David Adelson; Randall A Ruppel; Joseph A Carcillo; Stephen R Wisniewski; Zaichuan Mi; Keri L Janesko; Robert S B Clark; Donald W Marion; Steven H Graham; Edwin K Jackson
Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity.
Critical care medicine 2001;29(12):2287-93.
2001: Kimberly D Statler; Larry W Jenkins; C Edward Dixon; Robert S B Clark; Donald W Marion; Patrick M Kochanek
The simple model versus the super model: translating experimental traumatic brain injury research to the bedside.
Journal of neurotrauma 2001;18(11):1195-206.
2001: Patrick M Kochanek; Robert S B Clark; Randall A Ruppel; C Edward Dixon
Cerebral resuscitation after traumatic brain injury and cardiopulmonary arrest in infants and children in the new millennium.
Pediatric clinics of North America 2001;48(3):661-81.
2001: Michael J Bell; Claudia S Robertson; Patrick M Kochanek; J Clay Goodman; Shankar Gopinath; Joseph A Carcillo; Robert S B Clark; Donald W Marion; Zaichuan Mi; Edwin K Jackson
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.
Critical care medicine 2001;29(2):399-404.
2001: Patrick M Kochanek; Keri L Janesko; Larry W Jenkins; Hong Qu Yan; Melina R Kibbe; P Robichaud; A C Wooditch; Robert S B Clark; C Edward Dixon; Donald W Marion; Timothy R Billiar
Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice.
Journal of neurotrauma 2001;18(1):73-82.
2001: Randall A Ruppel; Patrick M Kochanek; P David Adelson; Marie E Rose; Stephen R Wisniewski; Michael J Bell; Robert S B Clark; Donald W Marion; Steven H Graham
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.
The Journal of pediatrics 2001;138(1):18-25.
2000: Kimberly D Statler; Patrick M Kochanek; C Edward Dixon; Henry L Alexander; Warner David; Robert S B Clark; Stephen R Wisniewski; Steven H Graham; Larry W Jenkins; Donald W Marion; Peter Safar
Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats.
Journal of neurotrauma 2000;17(12):1179-89.
2000: Michael J Whalen; Timothy M Carlos; Stephen R Wisniewski; Robert S B Clark; J A Mellick; Donald W Marion; Patrick M Kochanek
Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats.
Critical care medicine 2000;28(11):3710-7.
2000: Steven H Graham; Jun Chen; Robert S B Clark
Bcl-2 family gene products in cerebral ischemia and traumatic brain injury.
Journal of neurotrauma 2000;17(10):831-41.
2000: Courtney L Robertson; Robert S B Clark; C Edward Dixon; Henry L Alexander; Steven H Graham; Stephen R Wisniewski; Donald W Marion; Peter Safar; Patrick M Kochanek
No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats.
Critical care medicine 2000;28(9):3218-23.
2000: Robert S B Clark; Patrick M Kochanek; P David Adelson; Michael J Bell; Joseph A Carcillo; M Chen; Stephen R Wisniewski; Keri L Janesko; Michael J Whalen; Steven H Graham
Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury.
The Journal of pediatrics 2000;137(2):197-204.
2000: David C Henshall; Robert S B Clark; P David Adelson; Minzhi Chen; simon simon watkins; Roger P. Simon
Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy.
Neurology 2000;55(2):250-7.
2000: Michael J Whalen; Timothy M Carlos; Patrick M Kochanek; Stephen R Wisniewski; Michael J Bell; Robert S B Clark; Steven T DeKosky; Donald W Marion; P David Adelson
Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury.
Critical care medicine 2000;28(4):929-34.
2000: Michael J Whalen; Timothy M Carlos; C Edward Dixon; P Robichaud; Robert S B Clark; Donald W Marion; Patrick M Kochanek
Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1.
Journal of leukocyte biology 2000;67(2):160-8.
2000: Robert S B Clark; Patrick M Kochanek; simon simon watkins; Minzhi Chen; C Edward Dixon; N A Seidberg; John A Melick; JE Loeffert; Paula D Nathaniel; KL Jin; Steven H Graham
Caspase-3 mediated neuronal death after traumatic brain injury in rats.
Journal of neurochemistry 2000;74(2):740-53.
2000: Michael J Whalen; Robert S B Clark; C Edward Dixon; P Robichaud; Donald W Marion; Vincent A Vagni; S Graham; Laszlo Virag; G Hasko; R Stachlewitz; Csaba Szabó; Patrick M Kochanek
Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.
Acta neurochirurgica. Supplement 2000;76():61-4.
1999: EH Sinz; Patrick M Kochanek; C Edward Dixon; Robert S B Clark; Joseph A Carcillo; Joanne K Schiding; Minzhi Chen; Stephen R Wisniewski; Timothy M Carlos; D Williams; Steven T DeKosky; simon simon watkins; Donald W Marion; Timothy R Billiar
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
The Journal of clinical investigation 1999;104(5):647-56.
1999: Michael J Whalen; Robert S B Clark; C Edward Dixon; P Robichaud; Donald W Marion; Vincent A Vagni; Steven H Graham; Laszlo Virag; G Hasko; R Stachlewitz; Csaba Szabó; Patrick M Kochanek
Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(8):835-42.
1999: Michael J Whalen; Timothy M Carlos; Patrick M Kochanek; Robert S B Clark; S Heineman; Joanne K Schiding; Darcy Franicola; F Memarzadeh; W Lo; Donald W Marion; Steven T DeKosky
Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats.
Journal of neurotrauma 1999;16(7):583-94.
1999: Michael J Whalen; Timothy M Carlos; Robert S B Clark; Patrick M Kochanek
An acute inflammatory response to the use of granulocyte colony-stimulating factor to prevent infections in patients with brain injury: what about the brain?
Critical care medicine 1999;27(5):1014-8.
1999: Robert S B Clark; Patrick M Kochanek; Minzhi Chen; simon simon watkins; D W Marion; Jun Chen; R L Hamilton; JE Loeffert; Steven H Graham
Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):813-21.
1999: Michael J Whalen; Timothy M Carlos; C Edward Dixon; Joanne K Schiding; Robert S B Clark; E Baum; Hong Qu Yan; Donald W Marion; Patrick M Kochanek
Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome.
Journal of neurotrauma 1999;16(4):299-309.
1999: Michael J Bell; Patrick M Kochanek; Melvyn P Heyes; Stephen R Wisniewski; EH Sinz; Robert S B Clark; Andrew R Blight; Donald W Marion; P David Adelson
Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury.
Critical care medicine 1999;27(3):493-7.
1998: Michael J Whalen; Timothy M Carlos; Patrick M Kochanek; Stephen R Wisniewski; Michael J Bell; Joseph A Carcillo; Robert S B Clark; Steven T DeKosky; P David Adelson
Soluble adhesion molecules in CSF are increased in children with severe head injury.
Journal of neurotrauma 1998;15(10):777-87.
1998: EH Sinz; Patrick M Kochanek; Melvyn P Heyes; Stephen R Wisniewski; Michael J Bell; Robert S B Clark; Steven T DeKosky; Andrew R Blight; Donald W Marion
Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(6):610-5.
1998: Minzhi Chen; Robert S B Clark; Patrick M Kochanek; Jun Chen; Joanne K Schiding; R Anne Stetler; Roger P. Simon; Steven H Graham
72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats.
Journal of neurotrauma 1998;15(3):171-81.
1998: Michael J Bell; Patrick M Kochanek; Joseph A Carcillo; Zaichuan Mi; Joanne K Schiding; Stephen R Wisniewski; Robert S B Clark; C Edward Dixon; Donald W Marion; E Jackson
Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat.
Journal of neurotrauma 1998;15(3):163-70.
1998: MICHAEL LEIGHTON FORBES; Robert S B Clark; C Edward Dixon; Steven H Graham; Donald W Marion; Steven T DeKosky; Joanne K Schiding; Patrick M Kochanek
Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.
Journal of neurosurgery 1998;88(3):549-56.
1997: Robert S B Clark; Joseph A Carcillo; Patrick M Kochanek; Walter Obrist; Edwin K Jackson; Zaichuan Mi; S R Wisneiwski; Michael J Bell; Donald W Marion
Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans.
Neurosurgery 1997;41(6):1284-92; discussion 1292-3.
1997: Robert S B Clark; Jun Chen; simon simon watkins; Patrick M Kochanek; Minzhi Chen; R Anne Stetler; JE Loeffert; Steven H Graham
Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(23):9172-82.
1997: Michael J Whalen; Timothy M Carlos; Robert S B Clark; Donald W Marion; Steven T DeKosky; S Heineman; Joanne K Schiding; F Memarzadeh; Patrick M Kochanek
The effect of brain temperature on acute inflammation after traumatic brain injury in rats.
Journal of neurotrauma 1997;14(8):561-72.
1997: Michael J Bell; Patrick M Kochanek; Lesley A Doughty; Joseph A Carcillo; P David Adelson; Robert S B Clark; Stephen R Wisniewski; Michael J Whalen; Steven T DeKosky
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
Journal of neurotrauma 1997;14(7):451-7.
1997: Robert S B Clark; Patrick M Kochanek; C Edward Dixon; Minzhi Chen; Donald W Marion; S Heineman; Steven T DeKosky; Steven H Graham
Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.
Journal of neurotrauma 1997;14(4):179-89.
1997: Timothy M Carlos; Robert S B Clark; D Franicola-Higgins; Joanne K Schiding; Patrick M Kochanek
Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats.
Journal of leukocyte biology 1997;61(3):279-85.
1997: Michael J Whalen; Timothy M Carlos; Robert S B Clark; Donald W Marion; M S DeKosky; S Heineman; Joanne K Schiding; F Memarzadeh; C Edward Dixon; Patrick M Kochanek
The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats.
Acta neurochirurgica. Supplement 1997;70():260-1.
1997: Patrick M Kochanek; Robert S B Clark; Walter Obrist; Joseph A Carcillo; Edwin K Jackson; Zaichuan Mi; Stephen R Wisniewski; Michael J Bell; Donald W Marion
The role of adenosine during the period of delayed cerebral swelling after severe traumatic brain injury in humans.
Acta neurochirurgica. Supplement 1997;70():109-11.
1997: Michael J Bell; Patrick M Kochanek; Lesley A Doughty; Joseph A Carcillo; P David Adelson; Robert S B Clark; Michael J Whalen; Steven T DeKosky
Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.
Acta neurochirurgica. Supplement 1997;70():96-7.
1996: Robert S B Clark; Patrick M Kochanek; Walter Obrist; H R Wong; Timothy R Billiar; Stephen R Wisniewski; Donald W Marion
Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans.
Critical care medicine 1996;24(7):1243-51.
1996: Robert S B Clark; Timothy M Carlos; Joanne K Schiding; M Bree; L A Fireman; Steven T DeKosky; Patrick M Kochanek
Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats.
Journal of neurotrauma 1996;13(6):333-41.
1996: Robert S B Clark; Patrick M Kochanek; M A Schwarz; Joanne K Schiding; D S Turner; M Chen; Timothy M Carlos; simon simon watkins
Inducible nitric oxide synthase expression in cerebrovascular smooth muscle and neutrophils after traumatic brain injury in immature rats.
Pediatric research 1996;39(5):784-90.
1996: Robert S B Clark; Patrick M Kochanek; Donald W Marion; Joanne K Schiding; M White; Alan Palmer; Steven T DeKosky
Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(2):253-61.
1995: Patrick M Kochanek; Donald W Marion; W Zhang; Joanne K Schiding; M White; Alan Palmer; Robert S B Clark; Mark E O'Malley; Scot D Styren; C Ho
Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume.
Journal of neurotrauma 1995;12(6):1015-25.
1994: Robert S B Clark; Joanne K Schiding; S L Kaczorowski; Donald W Marion; Patrick M Kochanek
Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models.
Journal of neurotrauma 1994;11(5):499-506.