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Anthony Clarke

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Ordu Emel B; Cameron Gus; Clarke Anthony R; Karagüler Nevin Gül
Kinetic and thermodynamic properties of the folding and assembly of formate dehydrogenase.
Hart Tanya; Hosszu Laszlo L P; Trevitt Clare R; Jackson Graham S; Waltho Jonathan P; Collinge John; Clarke Anthony R
Folding kinetics of the human prion protein probed by temperature jump.
Robson Alice; Gold Vicki A M; Hodson Skye; Clarke Anthony R; Collinson Ian
Energy transduction in protein transport and the ATP hydrolytic cycle of SecA.

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All Publications

2009: Ordu Emel B; Cameron Gus; Clarke Anthony R; Karagüler Nevin Gül
Kinetic and thermodynamic properties of the folding and assembly of formate dehydrogenase.
FEBS letters 2009;583(17):2887-92.
2009: Hart Tanya; Hosszu Laszlo L P; Trevitt Clare R; Jackson Graham S; Waltho Jonathan P; Collinge John; Clarke Anthony R
Folding kinetics of the human prion protein probed by temperature jump.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5651-6.
2009: Robson Alice; Gold Vicki A M; Hodson Skye; Clarke Anthony R; Collinson Ian
Energy transduction in protein transport and the ATP hydrolytic cycle of SecA.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5111-6.
2009: Edgeworth Julie Ann; Jackson Graham S; Clarke Anthony R; Weissmann Charles; Collinge John
Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3479-83.
2009: Cliff Matthew J; Craven C Jeremy; Marston James P; Hounslow Andrea M; Clarke Anthony R; Waltho Jonathan P
The denatured state of N-PGK is compact and predominantly disordered.
Journal of molecular biology 2009;385(1):266-77.
2008: Clarke Anthony R
The importance of presentation.
Nature structural & molecular biology 2008;15(12):1234-5.
2008: Cronier Sabrina; Gros Nathalie; Tattum M Howard; Jackson Graham S; Clarke Anthony R; Collinge John; Wadsworth Jonathan D F
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin.
The Biochemical journal 2008;416(2):297-305.
2008: Conners Rebecca; Hill Darryl J; Borodina Elena; Agnew Christopher; Daniell Sarah J; Burton Nicholas M; Sessions Richard B; Clarke Anthony R; Catto Lucy E; Lammie Donna; Wess Timothy; Brady R Leo; Virji Mumtaz
The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil.
The EMBO journal 2008;27(12):1779-89.
2008: Bigotti Maria Giulia; Clarke Anthony R
Chaperonins: The hunt for the Group II mechanism.
Archives of biochemistry and biophysics 2008;474(2):331-9.
2007: Karagüler N G; Sessions R B; Binay B; Ordu E B; Clarke A R
Protein engineering applications of industrially exploitable enzymes: Geobacillus stearothermophilus LDH and Candida methylica FDH.
Biochemical Society transactions 2007;35(Pt 6):1610-5.
2007: Robson Alice; Booth Antonia E G; Gold Vicki A M; Clarke Anthony R; Collinson Ian
A large conformational change couples the ATP binding site of SecA to the SecY protein channel.
Journal of molecular biology 2007;374(4):965-76.
2007: Collinge John; Clarke Anthony R
A general model of prion strains and their pathogenicity.
Science (New York, N.Y.) 2007;318(5852):930-6.
2007: Khalili-Shirazi Azadeh; Kaisar Maria; Mallinson Gary; Jones Samantha; Bhelt Daljit; Fraser Carol; Clarke Anthony R; Hawke Simon H; Jackson Graham S; Collinge John
Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc.
Biochimica et biophysica acta 2007;1774(11):1438-50.
2007: Karagüler Nevin Gül; Sessions Richard B; Clarke Anthony R
Effects of disulphide bridges on the activity and stability of the formate dehydrogenase from Candida methylica.
Biotechnology letters 2007;29(9):1375-80.
2007: Tyka Michael D; Sessions Richard B; Clarke Anthony R
Absolute free-energy calculations of liquids using a harmonic reference state.
The journal of physical chemistry. B 2007;111(32):9571-80.
2007: Shoemark Deborah K; Cliff Matthew J; Sessions Richard B; Clarke Anthony R
Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum.
The FEBS journal 2007;274(11):2738-48.
2007: Gold Vicki A M; Robson Alice; Clarke Anthony R; Collinson Ian
Allosteric regulation of SecA: magnesium-mediated control of conformation and activity.
The Journal of biological chemistry 2007;282(24):17424-32.
2007: Kristiansen Mark; Deriziotis Pelagia; Dimcheff Derek E; Jackson Graham S; Ovaa Huib; Naumann Heike; Clarke Anthony R; van Leeuwen Fijs W B; Menéndez-Benito Victoria; Dantuma Nico P; Portis John L; Collinge John; Tabrizi Sarah J
Disease-associated prion protein oligomers inhibit the 26S proteasome.
Molecular cell 2007;26(2):175-88.
2007: Stone Lisa A; Jackson Graham S; Collinge John; Wadsworth Jonathan D F; Clarke Anthony R
Inhibition of proteinase K activity by copper(II) ions.
Biochemistry 2007;46(1):245-52.
2006: Wells Mark A; Jelinska Clare; Hosszu Laszlo L P; Craven C Jeremy; Clarke Anthony R; Collinge John; Waltho Jonathan P; Jackson Graham S
Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4.
The Biochemical journal 2006;400(3):501-10.
2006: Wells Mark A; Jackson Graham S; Jones Samantha; Hosszu Laszlo L P; Craven C Jeremy; Clarke Anthony R; Collinge John; Waltho Jonathan P
A reassessment of copper(II) binding in the full-length prion protein.
The Biochemical journal 2006;399(3):435-44.
2006: Clarke Anthony R
Cytosolic chaperonins: a question of promiscuity.
Molecular cell 2006;24(2):165-7.
2006: Bigotti Maria Giulia; Bellamy Stuart R W; Clarke Anthony R
The asymmetric ATPase cycle of the thermosome: elucidation of the binding, hydrolysis and product-release steps.
Journal of molecular biology 2006;362(4):835-43.
2006: Tyka Michael D; Clarke Anthony R; Sessions Richard B
An efficient, path-independent method for free-energy calculations.
The journal of physical chemistry. B 2006;110(34):17212-20.
2006: Lewis Patrick A; Tattum M Howard; Jones Samantha; Bhelt Daljit; Batchelor Mark; Clarke Anthony R; Collinge John; Jackson Graham S
Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.
The Journal of general virology 2006;87(Pt 8):2443-9.
2006: Cliff Matthew J; Limpkin Claire; Cameron Angus; Burston Steven G; Clarke Anthony R
Elucidation of steps in the capture of a protein substrate for efficient encapsulation by GroE.
The Journal of biological chemistry 2006;281(30):21266-75.
2006: Soufi Abdenour; Smith Corinne; Clarke Anthony R; Gaston Kevin; Jayaraman Padma-Sheela
Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.
Journal of molecular biology 2006;358(4):943-62.
2006: Lewis Patrick A; Properzi Francesca; Prodromidou Kanella; Clarke Anthony R; Collinge John; Jackson Graham S
Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.
The Biochemical journal 2006;395(2):443-8.
2006: Tattum M Howard; Cohen-Krausz Sara; Thumanu Kanjana; Wharton Christopher W; Khalili-Shirazi Azadeh; Jackson Graham S; Orlova Elena V; Collinge John; Clarke Anthony R; Saibil Helen R
Elongated oligomers assemble into mammalian PrP amyloid fibrils.
Journal of molecular biology 2006;357(3):975-85.
2006: Reed Michelle A C; Jelinska Clare; Syson Karl; Cliff Matthew J; Splevins Andrew; Alizadeh Tooba; Hounslow Andrea M; Staniforth Rosemary A; Clarke Anthony R; Craven C Jeremy; Waltho Jonathan P
The denatured state under native conditions: a non-native-like collapsed state of N-PGK.
Journal of molecular biology 2006;357(2):365-72.
2006: Conners Rebecca; Hooley Elizabeth; Clarke Anthony R; Thomas Siân; Brady R Leo
Recognition of oxidatively modified bases within the biotin-binding site of avidin.
Journal of molecular biology 2006;357(1):263-74.
2006: Hooley Elizabeth; Fairweather Victoria; Clarke Anthony R; Gaston Kevin; Brady R Leo
The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.
Nucleic acids research 2006;34(14):3897-908.
2005: Hosszu Laszlo L P; Wells Mark A; Jackson Graham S; Jones Samantha; Batchelor Mark; Clarke Anthony R; Craven C Jeremy; Waltho Jonathan P; Collinge John
Definable equilibrium states in the folding of human prion protein.
Biochemistry 2005;44(50):16649-57.
2005: Mason Jody M; Cliff Matthew J; Sessions Richard B; Clarke Anthony R
Low energy pathways and non-native interactions: the influence of artificial disulfide bridges on the mechanism of folding.
The Journal of biological chemistry 2005;280(49):40494-9.
2005: Jones Samantha; Batchelor Mark; Bhelt Daljit; Clarke Anthony R; Collinge John; Jackson Graham S
Recombinant prion protein does not possess SOD-1 activity.
The Biochemical journal 2005;392(Pt 2):309-12.
2005: Bigotti Maria Giulia; Clarke Anthony R
Cooperativity in the thermosome.
Journal of molecular biology 2005;348(1):13-26.
2005: Khalili-Shirazi Azadeh; Quaratino Sonia; Londei Marco; Summers Linda; Tayebi Mourad; Clarke Anthony R; Hawke Simon H; Jackson Graham S; Collinge John
Protein conformation significantly influences immune responses to prion protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3256-63.
2005: Jackson Graham S; McKintosh Edward; Flechsig Eckhard; Prodromidou Kanella; Hirsch Petra; Linehan Jackie; Brandner Sebastian; Clarke Anthony R; Weissmann Charles; Collinge John
An enzyme-detergent method for effective prion decontamination of surgical steel.
The Journal of general virology 2005;86(Pt 3):869-78.
2004: Poso Daniel; Clarke Anthony R; Burston Steven G
Identification of a major inter-ring coupling step in the GroEL reaction cycle.
The Journal of biological chemistry 2004;279(37):38111-7.
2004: Beringue Vincent; Vilette Didier; Mallinson Gary; Archer Fabienne; Kaisar Maria; Tayebi Mourad; Jackson Graham S; Clarke Anthony R; Laude Hubert; Collinge John; Hawke Simon
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines.
The Journal of biological chemistry 2004;279(38):39671-6.
2004: Karagüler Nevin Gül; Sessions Richard B; Moreton Kathleen M; Clarke Anthony R; Holbrook J John
Estimating the energetic contribution of hydrogen bonding to the stability of Candida methylica formate dehydrogenase by using double mutant cycle.
Biotechnology letters 2004;26(14):1137-40.
2004: Hosszu Laszlo L P; Jackson Graham S; Trevitt Clare R; Jones Samantha; Batchelor Mark; Bhelt Daljit; Prodromidou Kanella; Clarke Anthony R; Waltho Jonathan P; Collinge John
The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.
The Journal of biological chemistry 2004;279(27):28515-21.
2004: Poso Daniel; Clarke Anthony R; Burston Steven G
A kinetic analysis of the nucleotide-induced allosteric transitions in a single-ring mutant of GroEL.
Journal of molecular biology 2004;338(5):969-77.
2004: Cliff Matthew J; Higgins Lee D; Sessions Richard B; Waltho Jon P; Clarke Anthony R
Beyond the EX1 limit: probing the structure of high-energy states in protein unfolding.
Journal of molecular biology 2004;336(2):497-508.
2003: Reed Michelle A C; Hounslow Andrea M; Sze K H; Barsukov Igor G; Hosszu Laszlo L P; Clarke Anthony R; Craven C Jeremy; Waltho Jonathan P
Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.
Journal of molecular biology 2003;330(5):1189-201.
2003: Hawrani Ayman; Dempsey Christopher E; Banfield Mark J; Scott David J; Clarke Anthony R; Kenny Brendan
Effect of protein kinase A-mediated phosphorylation on the structure and association properties of the enteropathogenic Escherichia coli Tir virulence protein.
The Journal of biological chemistry 2003;278(28):25839-46.
2002: Mason Jody M; Gibbs Nicholas; Sessions Richard B; Clarke Anthony R
The influence of intramolecular bridges on the dynamics of a protein folding reaction.
Biochemistry 2002;41(40):12093-9.
2002: Simm Alan M; Higgins Catherine S; Carenbauer Anne L; Crowder Michael W; Bateson John H; Bennett Peter M; Clarke Anthony R; Halford Stephen E; Walsh Timothy R
Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysis.
The Journal of biological chemistry 2002;277(27):24744-52.
2002: Lesieur Claire; Cliff Matthew J; Carter Rachel; James Roger F L; Clarke Anthony R; Hirst Timothy R
A kinetic model of intermediate formation during assembly of cholera toxin B-subunit pentamers.
The Journal of biological chemistry 2002;277(19):16697-704.
2002: Naylor Ruth L; Robertson Alan G S; Allen Shelley J; Sessions Richard B; Clarke Anthony R; Mason Grant G F; Burston Judy J; Tyler Sue J; Wilcock Gordon K; Dawbarn David
A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
Biochemical and biophysical research communications 2002;291(3):501-7.
2002: Alexander Lucille G; Sessions Richard B; Clarke Anthony R; Tatham Arthur S; Shewry Peter R; Napier Johnathan A
Characterization and modelling of the hydrophobic domain of a sunflower oleosin.
Planta 2002;214(4):546-51.
2001: Spencer J; Clarke A R; Walsh T R
Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.
The Journal of biological chemistry 2001;276(36):33638-44.
2001: Townley H E; Sessions R B; Clarke A R; Dafforn T R; Griffiths W T
Protochlorophyllide oxidoreductase: a homology model examined by site-directed mutagenesis.
Proteins 2001;44(3):329-35.
2001: Jackson G S; Murray I; Hosszu L L; Gibbs N; Waltho J P; Clarke A R; Collinge J
Location and properties of metal-binding sites on the human prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8531-5.
2001: Kedzierski P; Moreton K; Clarke A R; Holbrook J J
The A245K mutation exposes another stage of the bacterial L-lactate dehydrogenase reaction mechanism.
Biochemistry 2001;40(24):7247-52.
2001: Gibbs N; Clarke A R; Sessions R B
Ab initio protein structure prediction using physicochemical potentials and a simplified off-lattice model.
Proteins 2001;43(2):186-202.
2001: Robertson A G; Banfield M J; Allen S J; Dando J A; Mason G G; Tyler S J; Bennett G S; Brain S D; Clarke A R; Naylor R L; Wilcock G K; Brady R L; Dawbarn D
Identification and structure of the nerve growth factor binding site on TrkA.
Biochemical and biophysical research communications 2001;282(1):131-41.
2001: Clarke A R; Jackson G S; Collinge J
The molecular biology of prion propagation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):185-95.
2000: Poso D; Sessions R B; Lorch M; Clarke A R
Progressive stabilization of intermediate and transition states in protein folding reactions by introducing surface hydrophobic residues.
The Journal of biological chemistry 2000;275(46):35723-6.
2000: Staniforth R A; Dean J L; Zhong Q; Zerovnik E; Clarke A R; Waltho J P
The major transition state in folding need not involve the immobilization of side chains.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5790-5.
2000: Lorch M; Mason J M; Sessions R B; Clarke A R
Effects of mutations on the thermodynamics of a protein folding reaction: implications for the mechanism of formation of the intermediate and transition states.
Biochemistry 2000;39(12):3480-5.
2000: Pandya M J; Sessions R B; Williams P B; Dempsey C E; Tatham A S; Shewry P R; Clarke A R
Structural characterization of a methionine-rich, emulsifying protein from sunflower seed.
Proteins 2000;38(3):341-9.
2000: Jackson G S; Clarke A R
Mammalian prion proteins.
Current opinion in structural biology 2000;10(1):69-74.
2000: Webster K; Parish J; Pandya M; Stern P L; Clarke A R; Gaston K
The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.
The Journal of biological chemistry 2000;275(1):87-94.
1999: Cliff M J; Kad N M; Hay N; Lund P A; Webb M R; Burston S G; Clarke A R
A kinetic analysis of the nucleotide-induced allosteric transitions of GroEL.
Journal of molecular biology 1999;293(3):667-84.
1999: Pandya M J; Williams P B; Dempsey C E; Shewry P R; Clarke A R
Direct kinetic evidence for folding via a highly compact, misfolded state.
The Journal of biological chemistry 1999;274(38):26828-37.
1999: Hosszu L L; Baxter N J; Jackson G S; Power A; Clarke A R; Waltho J P; Craven C J; Collinge J
Structural mobility of the human prion protein probed by backbone hydrogen exchange.
Nature structural biology 1999;6(8):740-3.
1999: Luckett S; Garcia R S; Barker J J; Konarev A V; Shewry P R; Clarke A R; Brady R L
High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds.
Journal of molecular biology 1999;290(2):525-33.
1999: Hewitt C O; Eszes C M; Sessions R B; Moreton K M; Dafforn T R; Takei J; Dempsey C E; Clarke A R; Holbrook J J
A general method for relieving substrate inhibition in lactate dehydrogenases.
Protein engineering 1999;12(6):491-6.
1999: Wadsworth J D; Hill A F; Joiner S; Jackson G S; Clarke A R; Collinge J
Strain-specific prion-protein conformation determined by metal ions.
Nature cell biology 1999;1(1):55-9.
1999: Jackson G S; Hill A F; Joseph C; Hosszu L; Power A; Waltho J P; Clarke A R; Collinge J
Multiple folding pathways for heterologously expressed human prion protein.
Biochimica et biophysica acta 1999;1431(1):1-13.
1999: Jackson G S; Hosszu L L; Power A; Hill A F; Kenney J; Saibil H; Craven C J; Waltho J P; Clarke A R; Collinge J
Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.
Science (New York, N.Y.) 1999;283(5409):1935-7.
1999: Chapman A D; Cortés A; Dafforn T R; Clarke A R; Brady R L
Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD.
Journal of molecular biology 1999;285(2):703-12.
1999: Lorch M; Mason J M; Clarke A R; Parker M J
Effects of core mutations on the folding of a beta-sheet protein: implications for backbone organization in the I-state.
Biochemistry 1999;38(4):1377-85.
1999: Hayes M V; Sessions R B; Brady R L; Clarke A R
Engineered assembly of intertwined oligomers of an immunoglobulin chain.
Journal of molecular biology 1999;285(4):1857-67.
1999: Sessions R B; Hayes M V; Murray A J; Clarke A R; Brady R L
One sequence, four folds: transitions between an ensemble of metastable folds for the N-terminal domain of CD2.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 1999;():566-77.
1998: Kad N M; Ranson N A; Cliff M J; Clarke A R
Asymmetry, commitment and inhibition in the GroE ATPase cycle impose alternating functions on the two GroEL rings.
Journal of molecular biology 1998;278(1):267-78.
1998: Takei J; Reményi A; Clarke A R; Dempsey C E
Self-association of disulfide-dimerized melittin analogues.
Biochemistry 1998;37(16):5699-708.
1998: Parker M J; Dempsey C E; Hosszu L L; Waltho J P; Clarke A R
Topology, sequence evolution and folding dynamics of an immunoglobulin domain.
Nature structural biology 1998;5(3):194-8.
1998: Parker M J; Lorch M; Sessions R B; Clarke A R
Thermodynamic properties of transient intermediates and transition states in the folding of two contrasting protein structures.
Biochemistry 1998;37(8):2538-45.
1997: Sanchez-Perez A M; Soriano S; Clarke A R; Gaston K
Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis.
The Journal of general virology 1997;78 ( Pt 11)():3009-18.
1997: Parker M J; Dempsey C E; Lorch M; Clarke A R
Acquisition of native beta-strand topology during the rapid collapse phase of protein folding.
Biochemistry 1997;36(43):13396-405.
1997: Hosszu L L; Craven C J; Parker M J; Lorch M; Spencer J; Clarke A R; Waltho J P
Structure of a kinetic protein folding intermediate by equilibrium amide exchange.
Nature structural biology 1997;4(10):801-4.
1997: Clarke A R; Waltho J P
Protein folding and intermediates.
Current opinion in biotechnology 1997;8(4):400-10.
1997: Holden P H; Asopa V; Robertson A G; Clarke A R; Tyler S; Bennett G S; Brain S D; Wilcock G K; Allen S J; Smith S K; Dawbarn D
Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
Nature biotechnology 1997;15(7):668-72.
1997: Stephens D J; Crump C M; Clarke A R; Banting G
Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex.
The Journal of biological chemistry 1997;272(22):14104-9.
1997: Parker M J; Clarke A R
Amide backbone and water-related H/D isotope effects on the dynamics of a protein folding reaction.
Biochemistry 1997;36(19):5786-94.
1997: Sessions R B; Dewar V; Clarke A R; Holbrook J J
A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.
Protein engineering 1997;10(4):301-6.
1997: Ranson N A; Burston S G; Clarke A R
Binding, encapsulation and ejection: substrate dynamics during a chaperonin-assisted folding reaction.
Journal of molecular biology 1997;266(4):656-64.
1997: Thain A; Webster K; Emery D; Clarke A R; Gaston K
DNA binding and bending by the human papillomavirus type 16 E2 protein. Recognition of an extended binding site.
The Journal of biological chemistry 1997;272(13):8236-42.
1997: Hosszu L L; Craven C J; Spencer J; Parker M J; Clarke A R; Kelly M; Waltho J P
Is the structure of the N-domain of phosphoglycerate kinase affected by isolation from the intact molecule?
Biochemistry 1997;36(2):333-40.
1996: Eszes C M; Sessions R B; Clarke A R; Moreton K M; Holbrook J J
Removal of substrate inhibition in a lactate dehydrogenase from human muscle by a single residue change.
FEBS letters 1996;399(3):193-7.
1996: Parker M J; Spencer J; Jackson G S; Burston S G; Hosszu L L; Craven C J; Waltho J P; Clarke A R
Domain behavior during the folding of a thermostable phosphoglycerate kinase.
Biochemistry 1996;35(49):15740-52.
1996: Thain A; Jenkins O; Clarke A R; Gaston K
CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences.
Journal of virology 1996;70(10):7233-5.
1996: Thain A; Gaston K; Jenkins O; Clarke A R
A method for the separation of GST fusion proteins from co-purifying GroEL.
Trends in genetics : TIG 1996;12(6):209-10.
1996: Trejo F; Costa M; Gelpí J L; Busquets M; Clarke A R; Holbrook J J; Cortés A
Cloning, sequencing and functional expression of a DNA encoding pig cytosolic malate dehydrogenase: purification and characterization of the recombinant enzyme.
Gene 1996;172(2):303-8.
1996: Clarke A R
Molecular chaperones in protein folding and translocation.
Current opinion in structural biology 1996;6(1):43-50.
1996: Parker M J; Sessions R B; Badcoe I G; Clarke A R
The development of tertiary interactions during the folding of a large protein.
Folding & design 1996;1(2):145-56.
1995: Taylor L S; York P; Williams A C; Edwards H G; Mehta V; Jackson G S; Badcoe I G; Clarke A R
Sucrose reduces the efficiency of protein denaturation by a chaotropic agent.
Biochimica et biophysica acta 1995;1253(1):39-46.
1995: Parker M J; Spencer J; Clarke A R
An integrated kinetic analysis of intermediates and transition states in protein folding reactions.
Journal of molecular biology 1995;253(5):771-86.
1995: Ranson N A; Dunster N J; Burston S G; Clarke A R
Chaperonins can catalyse the reversal of early aggregation steps when a protein misfolds.
Journal of molecular biology 1995;250(5):581-6.
1995: Burston S G; Ranson N A; Clarke A R
The origins and consequences of asymmetry in the chaperonin reaction cycle.
Journal of molecular biology 1995;249(1):138-52.
1995: Burston S G; Clarke A R
Molecular chaperones: physical and mechanistic properties.
Essays in biochemistry 1995;29():125-36.
1994: Chen S; Roseman A M; Hunter A S; Wood S P; Burston S G; Ranson N A; Clarke A R; Saibil H R
Location of a folding protein and shape changes in GroEL-GroES complexes imaged by cryo-electron microscopy.
Nature 1994;371(6494):261-4.
1994: Collinge J; Whittington M A; Sidle K C; Smith C J; Palmer M S; Clarke A R; Jefferys J G
Prion protein is necessary for normal synaptic function.
Nature 1994;370(6487):295-7.
1994: Staniforth R A; Burston S G; Atkinson T; Clarke A R
Affinity of chaperonin-60 for a protein substrate and its modulation by nucleotides and chaperonin-10.
The Biochemical journal 1994;300 ( Pt 3)():651-8.
1994: Staniforth R A; Cortés A; Burston S G; Atkinson T; Holbrook J J; Clarke A R
The stability and hydrophobicity of cytosolic and mitochondrial malate dehydrogenases and their relation to chaperonin-assisted folding.
FEBS letters 1994;344(2-3):129-35.
1994: el Hawrani A S; Moreton K M; Sessions R B; Clarke A R; Holbrook J J
Engineering surface loops of proteins--a preferred strategy for obtaining new enzyme function.
Trends in biotechnology 1994;12(5):207-11.
1993: Staniforth R A; Burston S G; Smith C J; Jackson G S; Badcoe I G; Atkinson T; Holbrook J J; Clarke A R
The energetics and cooperativity of protein folding: a simple experimental analysis based upon the solvation of internal residues.
Biochemistry 1993;32(15):3842-51.
1993: Jackson G S; Staniforth R A; Halsall D J; Atkinson T; Holbrook J J; Clarke A R; Burston S G
Binding and hydrolysis of nucleotides in the chaperonin catalytic cycle: implications for the mechanism of assisted protein folding.
Biochemistry 1993;32(10):2554-63.
1992: Wilks H M; Cortes A; Emery D C; Halsall D J; Clarke A R; Holbrook J J
Opportunities and limits in creating new enzymes. Experiences with the NAD-dependent lactate dehydrogenase frameworks of humans and bacteria.
Annals of the New York Academy of Sciences 1992;672():80-93.
1992: Burston S G; Sleigh R; Halsall D J; Smith C J; Holbrook J J; Clarke A R
The influence of chaperonins on protein folding. A mechanism for increasing the yield of the native form.
Annals of the New York Academy of Sciences 1992;672():1-9.
1992: Wilks H M; Moreton K M; Halsall D J; Hart K W; Sessions R D; Clarke A R; Holbrook J J
Design of a specific phenyllactate dehydrogenase by peptide loop exchange on the Bacillus stearothermophilus lactate dehydrogenase framework.
Biochemistry 1992;31(34):7802-6.
1992: Cortes A; Emery D C; Halsall D J; Jackson R M; Clarke A R; Holbrook J J
Charge balance in the alpha-hydroxyacid dehydrogenase vacuole: an acid test.
Protein science : a publication of the Protein Society 1992;1(7):892-901.
1992: Hsu R Y; Glynias M J; Satterlee J; Feeney R; Clarke A R; Emery D C; Roe B A; Wilson R K; Goodridge A G; Holbrook J J
Duck liver 'malic' enzyme. Expression in Escherichia coli and characterization of the wild-type enzyme and site-directed mutants.
The Biochemical journal 1992;284 ( Pt 3)():869-76.
1991: Taylor J D; Badcoe I G; Clarke A R; Halford S E
EcoRV restriction endonuclease binds all DNA sequences with equal affinity.
Biochemistry 1991;30(36):8743-53.
1991: Badcoe I G; Smith C J; Wood S; Halsall D J; Holbrook J J; Lund P; Clarke A R
Binding of a chaperonin to the folding intermediates of lactate dehydrogenase.
Biochemistry 1991;30(38):9195-200.
1991: Clarke A R; Colebrook S; Cortes A; Emery D C; Halsall D J; Hart K W; Jackson R M; Wilks H M; Holbrook J J
Towards the construction of a universal NAD(P)(+)-dependent dehydrogenase: comparative and evolutionary considerations.
Biochemical Society transactions 1991;19(3):576-81.
1991: Dunn C R; Wilks H M; Halsall D J; Atkinson T; Clarke A R; Muirhead H; Holbrook J J
Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1991;332(1263):177-84.
1991: Smith C J; Clarke A R; Chia W N; Irons L I; Atkinson T; Holbrook J J
Detection and characterization of intermediates in the folding of large proteins by the use of genetically inserted tryptophan probes.
Biochemistry 1991;30(4):1028-36.
1990: Wilks H M; Halsall D J; Atkinson T; Chia W N; Clarke A R; Holbrook J J
Designs for a broad substrate specificity keto acid dehydrogenase.
Biochemistry 1990;29(37):8587-91.
1990: Barstow D A; Black G W; Sharman A F; Scawen M D; Atkinson T; Li S S; Chia W N; Clarke A R; Holbrook J J
Expression of the copy DNA for human A4 and B4 L-lactate dehydrogenases in Escherichia coli.
Biochimica et biophysica acta 1990;1087(1):73-9.
1990: Feeney R; Clarke A R; Holbrook J J
A single amino acid substitution in lactate dehydrogenase improves the catalytic efficiency with an alternative coenzyme.
Biochemical and biophysical research communications 1990;166(2):667-72.
1988: Wilks H M; Hart K W; Feeney R; Dunn C R; Muirhead H; Chia W N; Barstow D A; Atkinson T; Clarke A R; Holbrook J J
A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework.
Science (New York, N.Y.) 1988;242(4885):1541-4.
1988: Clarke A R; Wilks H M; Barstow D A; Atkinson T; Chia W N; Holbrook J J
An investigation of the contribution made by the carboxylate group of an active site histidine-aspartate couple to binding and catalysis in lactate dehydrogenase.
Biochemistry 1988;27(5):1617-22.
1988: Waldman A D; Hart K W; Clarke A R; Wigley D B; Barstow D A; Atkinson T; Chia W N; Holbrook J J
The use of genetically engineered tryptophan to identify the movement of a domain of B. stearothermophilus lactate dehydrogenase with the process which limits the steady-state turnover of the enzyme.
Biochemical and biophysical research communications 1988;150(2):752-9.
1987: Wigley D B; Clarke A R; Dunn C R; Barstow D A; Atkinson T; Chia W N; Muirhead H; Holbrook J J
The engineering of a more thermally stable lactate dehydrogenase by reduction of the area of a water-accessible hydrophobic surface.
Biochimica et biophysica acta 1987;916(1):145-8.
1987: Atkinson T; Barstow D A; Chia W N; Clarke A R; Hart K W; Waldman A D; Wigley D B; Wilks H; Holbrook J J
Mapping motion in large proteins by single tryptophan probes inserted by site-directed mutagenesis: lactate dehydrogenase.
Biochemical Society transactions 1987;15(5):991-3.
1987: Clarke A R; Smith C J; Hart K W; Wilks H M; Chia W N; Lee T V; Birktoft J J; Banaszak L J; Barstow D A; Atkinson T
Rational construction of a 2-hydroxyacid dehydrogenase with new substrate specificity.
Biochemical and biophysical research communications 1987;148(1):15-23.
1987: Hart K W; Clarke A R; Wigley D B; Waldman A D; Chia W N; Barstow D A; Atkinson T; Jones J B; Holbrook J J
A strong carboxylate-arginine interaction is important in substrate orientation and recognition in lactate dehydrogenase.
Biochimica et biophysica acta 1987;914(3):294-8.
1987: Hart K W; Clarke A R; Wigley D B; Chia W N; Barstow D A; Atkinson T; Holbrook J J
The importance of arginine 171 in substrate binding by Bacillus stearothermophilus lactate dehydrogenase.
Biochemical and biophysical research communications 1987;146(1):346-53.
1987: Barstow D A; Murphy J P; Sharman A F; Clarke A R; Holbrook J J; Atkinson T
Amino acid sequence of the L-lactate dehydrogenase of Bacillus caldotenax deduced from the nucleotide sequence of the cloned gene.
European journal of biochemistry / FEBS 1987;165(3):581-6.
1987: Clarke A R; Wigley D B; Barstow D A; Chia W N; Atkinson T; Holbrook J J
A single amino acid substitution deregulates a bacterial lactate dehydrogenase and stabilizes its tetrameric structure.
Biochimica et biophysica acta 1987;913(1):72-80.
1987: Waldman A D; Clarke A R; Wigley D B; Hart K W; Chia W N; Barstow D; Atkinson T; Munro I; Holbrook J J
The use of site-directed mutagenesis and time-resolved fluorescence spectroscopy to assign the fluorescence contributions of individual tryptophan residues in Bacillus stearothermophilus lactate dehydrogenase.
Biochimica et biophysica acta 1987;913(1):66-71.
1986: Clarke A R; Wigley D B; Chia W N; Barstow D; Atkinson T; Holbrook J J
Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis.
Nature 1986;324(6098):699-702.
1986: Barstow D A; Clarke A R; Chia W N; Wigley D; Sharman A F; Holbrook J J; Atkinson T; Minton N P
Cloning, expression and complete nucleotide sequence of the Bacillus stearothermophilus L-lactate dehydrogenase gene.
Gene 1986;46(1):47-55.
1985: Clarke A R; Waldman A D; Hart K W; Holbrook J J
The rates of defined changes in protein structure during the catalytic cycle of lactate dehydrogenase.
Biochimica et biophysica acta 1985;829(3):397-407.
1985: Clarke A R; Waldman A D; Munro I; Holbrook J J
Changes in the state of subunit association of lactate dehydrogenase from Bacillus stearothermophilus.
Biochimica et biophysica acta 1985;828(3):375-9.

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