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Alan Clarke

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Victoria Marsh; Geraint T Williams; Emma J Davies; Alan R Clarke
PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.
Madeleine Young; Liliana Ordonez; Alan R Clarke
What are the best routes to effectively model human colorectal cancer?
T Jardé; K L McQuillan; L Parry; B Alvares; Alan R Clarke; R J Evans; Gui-Jie Feng; T C Dale
In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.

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All Publications

2013: Victoria Marsh; Geraint T Williams; Emma J Davies; Alan R Clarke
PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.
The Journal of pathology 2013;230(2):165-73.
2013: Madeleine Young; Liliana Ordonez; Alan R Clarke
What are the best routes to effectively model human colorectal cancer?
Molecular oncology 2013;7(2):178-89.
2013: T Jardé; K L McQuillan; L Parry; B Alvares; Alan R Clarke; R J Evans; Gui-Jie Feng; T C Dale
In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.
Oncogene 2013;32(7):883-93.
2012: Gui Jie Feng; Thierry Jardé; Valerie Meniel; Oliver Poetz; Karen Reed; Xiao-Qing Wei; Geraint T Williams; Alan R Clarke; Welwyn Cotta; Rebecca Evans; Trevor C Dale
Conditional disruption of Axin1 leads to development of liver tumors in mice.
Gastroenterology 2012;143(6):1650-9.
2012: Karen R Reed; Simon J Tunster; Madeleine Young; Adam Carrico; Rosalind M John; Alan R Clarke
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
Gut 2012;61(10):1435-8.
2012: Lee Parry; Madeleine Young; Fatima El Marjou; Alan R Clarke
Evidence for a crucial role of paneth cells in mediating the intestinal response to injury.
Stem cells (Dayton, Ohio) 2012;31(4):776-85.
2011: P H S Shaw; T S Maughan; Alan R Clarke
Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apc(min/+) mouse.
British journal of cancer 2011;105(5):649-57.
2011: Lee Parry; Alan R Clarke
The Roles of the Methyl-CpG Binding Proteins in Cancer.
Genes & cancer 2011;2(6):618-30.
2011: Boris Y Shorning; Alan R Clarke
LKB1 loss of function studied in vivo.
FEBS letters 2011;585(7):958-66.
2011: Emma J Davies; Victoria Marsh; Alan R Clarke
Origin and maintenance of the intestinal cancer stem cell.
Molecular carcinogenesis 2011;50(4):254-63.
2011: Rhian S Thomas; Alan R Clarke; Victor C Duance; Emma J Blain
Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis.
Arthritis research & therapy 2011;13(6):R203.
2011: Boris Y Shorning; David Griffiths; Alan R Clarke
Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder.
PloS one 2011;6(1):e16209.
2010: Alicia M Cole; Rachel A Ridgway; Sahra E Derkits; Lee Parry; Nick Barker; Hans Clevers; Alan R Clarke; Owen J Sansom
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
EMBO molecular medicine 2010;2(11):472-86.
2010: Alicia M Cole; Kevin Myant; Karen R Reed; Rachel A Ridgway; Dimitris Athineos; Gijs R van den Brink; Vanesa Muncan; Hans Clevers; Alan R Clarke; Peter Sicinski; Owen J Sansom
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.
Cancer research 2010;70(20):8149-58.
2010: Gabrielle H Ashton; Jennifer P Morton; Kevin Myant; Toby J Phesse; Rachel A Ridgway; Victoria Marsh; Julie A Wilkins; Dimitris Athineos; Vanesa Muncan; Richard Kemp; Kristi Neufeld; Hans Clevers; Valerie G Brunton; Douglas J Winton; Xiaoyan Wang; Rosalie C Pelz; Alan R Clarke; Margaret C Frame; Owen J Sansom
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Developmental cell 2010;19(2):259-69.
2009: Trevor Hay; James R Matthews; Lucie Pietzka; Alan Lau; Aaron Cranston; Anders O H Nygren; Anthony Douglas-Jones; Graeme C M Smith; Niall M B Martin; Mark O'Connor; Alan R Clarke
Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.
Cancer research 2009;69(9):3850-5.
2009: K R Greenow; Alan R Clarke; R H Jones
Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation.
Oncogene 2009;28(11):1443-53.
2009: Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2009: T J Phesse; Alan R Clarke
Normal stem cells in cancer prone epithelial tissues.
British journal of cancer 2009;100(2):221-7.
2009: Boris Y Shorning; Joanna Zabkiewicz; Afshan McCarthy; Helen B Pearson; Douglas J Winton; Owen J Sansom; Alan Ashworth; Alan R Clarke
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.
PloS one 2009;4(1):e4264.
2009: Helen B Pearson; Toby J Phesse; Alan R Clarke
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Cancer research 2009;69(1):94-101.
2008: Karen R Reed; Dimitris Athineos; Valerie S Meniel; Julie A Wilkins; Rachel A Ridgway; Zoé D Burke; Vanesa Muncan; Alan R Clarke; Owen J Sansom
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18919-23.
2008: Victoria Marsh; Douglas J Winton; Geraint T Williams; Nicole Dubois; Andreas Trumpp; Owen J Sansom; Alan R Clarke
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.
Nature genetics 2008;40(12):1436-44.
2008: Toby J Phesse; Lee Parry; Karen R Reed; Kenneth B Ewan; Trevor C Dale; Owen J Sansom; Alan R Clarke
Deficiency of Mbd2 attenuates Wnt signaling.
Molecular and cellular biology 2008;28(19):6094-103.
2008: Alan R Clarke
Puma: mauling the intestinal crypt.
Cell stem cell 2008;2(6):517-8.
2008: Helen B Pearson; Afshan McCarthy; Christopher M P Collins; Alan Ashworth; Alan R Clarke
Lkb1 deficiency causes prostate neoplasia in the mouse.
Cancer research 2008;68(7):2223-32.
2008: Karen R Reed; Valerie Meniel; Victoria Marsh; Alicia Cole; Owen J Sansom; Alan R Clarke
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
BMC cancer 2008;8():162.
2007: Alan R Clarke
Cancer genetics: mouse models of intestinal cancer.
Biochemical Society transactions 2007;35(Pt 5):1338-41.
2007: Paul Shaw; Alan R Clarke
Murine models of intestinal cancer: recent advances.
DNA repair 2007;6(10):1403-12.
2007: Owen J Sansom; Fiona C Mansergh; Martin J Evans; Julie A Wilkins; Alan R Clarke
Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice.
Gut 2007;56(10):1410-4.
2007: Alan R Clarke; N Jones; F Pryde; Y Adachi; Owen J Sansom
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.
Oncogene 2007;26(43):6349-55.
2007: Owen J Sansom; Kathryn Maddison; Alan R Clarke
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer.
Nature clinical practice. Oncology 2007;4(5):305-15.
2007: Owen J Sansom; Valerie Meniel; Vanesa Muncan; Toby J Phesse; Julie A Wilkins; Karen R Reed; J Keith Vass; Dimitris Athineos; Hans Clevers; Alan R Clarke
Myc deletion rescues Apc deficiency in the small intestine.
Nature 2007;446(7136):676-9.
2007: James R Matthews; Susan M R Watson; Maxine C L Tevendale; Christine J Watson; Alan R Clarke
Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.
BMC cancer 2007;7():29.
2006: Alan R Clarke
Wnt signalling in the mouse intestine.
Oncogene 2006;25(57):7512-21.
2006: Vanesa Muncan; Owen J Sansom; Leon Tertoolen; Toby J Phesse; Harry Begthel; Elena Sancho; Alicia M Cole; Alex Gregorieff; Ignacio Moreno de Alboran; Hans Clevers; Alan R Clarke
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Molecular and cellular biology 2006;26(22):8418-26.
2006: Owen J Sansom; Valerie Meniel; Julie A Wilkins; Alicia M Cole; Karin A Oien; Victoria Marsh; Thomas J Jamieson; Carmen Guerra; Gabrielle H Ashton; Mariano Barbacid; Alan R Clarke
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14122-7.
2006: Alan R Clarke; Valerie Meniel
The intestinal stem cell niche studied through conditional transgenesis.
Ernst Schering Foundation symposium proceedings 2006;(5):99-108.
2006: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Jeffrey M Peters; Alan R Clarke
PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.
BMC cancer 2006;6():113.
2005: Owen J Sansom; David F R Griffiths; Karen R Reed; Douglas J Winton; Alan R Clarke
Apc deficiency predisposes to renal carcinoma in the mouse.
Oncogene 2005;24(55):8205-10.
2005: Trevor Hay; Helen Jenkins; Owen J Sansom; Niall M B Martin; Graeme C M Smith; Alan R Clarke
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Cancer research 2005;65(22):10145-8.
2005: Owen J Sansom; Karen R Reed; Marc van de Wetering; Vanesa Muncan; Douglas J Winton; Hans Clevers; Alan R Clarke
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.
The Journal of biological chemistry 2005;280(31):28463-7.
2005: Trevor Hay; Alan R Clarke
DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data.
Biochemical Society transactions 2005;33(Pt 4):715-7.
2005: Alan R Clarke
Studying the consequences of immediate loss of gene function in the intestine: APC.
Biochemical Society transactions 2005;33(Pt 4):665-6.
2005: Trevor Hay; Teresa Patrick; Douglas J Winton; Owen J Sansom; Alan R Clarke
Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.
Oncogene 2005;24(23):3842-6.
2005: James R Matthews; Alan R Clarke
p53 mediates a default programme of mammary gland involution in the absence of STAT3.
Oncogene 2005;24(19):3083-90.
2005: Owen J Sansom; Stefan M Bishop; Adrian Bird; Alan R Clarke
MBD2 deficiency does not accelerate p53 mediated lymphomagenesis.
Oncogene 2005;24(14):2430-2.
2005: Valérie Méniel; Trevor Hay; Anthony Douglas-Jones; Owen J Sansom; Alan R Clarke
Mutations in Apc and p53 synergize to promote mammary neoplasia.
Cancer research 2005;65(2):410-6.
2005: Kathryn Maddison; Alan R Clarke
New approaches for modelling cancer mechanisms in the mouse.
The Journal of pathology 2005;205(2):181-93.
2004: Joanna Zabkiewicz; Alan R Clarke
DNA damage-induced apoptosis: insights from the mouse.
Biochimica et biophysica acta 2004;1705(1):17-25.
2004: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Douglas J Winton; Jeffrey M Peters; Alan R Clarke
PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.
Oncogene 2004;23(55):8992-6.
2004: Owen J Sansom; Stefan M Bishop; Adrian Bird; Alan R Clarke
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.
Oncogene 2004;23(33):5693-6.
2004: Owen J Sansom; Karen R Reed; Anthony J Hayes; Heather Ireland; Hannah Brinkmann; Ian P Newton; Eduard Batlle; Patricia Simon-Assmann; Hans Clevers; Inke S Nathke; Alan R Clarke; Douglas J Winton
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Genes & development 2004;18(12):1385-90.
2004: Heather Ireland; Richard Kemp; Carol Houghton; Louise Howard; Alan R Clarke; Owen J Sansom; Douglas J Winton
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.
Gastroenterology 2004;126(5):1236-46.
2003: Owen J Sansom; Joanna Zabkiewicz; Stefan M Bishop; Jacky Guy; Adrian Bird; Alan R Clarke
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine.
Oncogene 2003;22(46):7130-6.
2003: Valerie Meniel; Alan R Clarke
Wnt-cadherin connections in normal and neoplastic mammary epithelium.
Journal of mammary gland biology and neoplasia 2003;8(4):435-47.
2003: Owen J Sansom; Stefan M Bishop; Helen Court; Sandra Dudley; R Michael Liskay; Alan R Clarke
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
DNA repair 2003;2(9):1029-39.
2003: Owen J Sansom; Jennifer Berger; Stefan M Bishop; Brian Hendrich; Adrian Bird; Alan R Clarke
Deficiency of Mbd2 suppresses intestinal tumorigenesis.
Nature genetics 2003;34(2):145-7.
2003: Robert A Screaton; Stephan Kiessling; Owen J Sansom; Catherine B Millar; Kathryn Maddison; Adrian Bird; Alan R Clarke; Steven M Frisch
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5211-6.
2003: Alan R Clarke; Owen J Sansom
Analyzing tumor suppressor activities in the murine small intestine.
Oncology research 2003;13(6-10):333-7.
2002: Christopher J Armit; Shirley O'Dea; Alan R Clarke; David J Harrison
Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.
BMC cell biology 2002;3():27.
2002: Ronald C J Gallagher; Trevor Hay; Valerie Meniel; Catherine Naughton; Thomas J Anderson; Hiroyuki Shibata; Masaki Ito; Hans Clevers; Tetsuo Noda; Owen J Sansom; John O Mason; Alan R Clarke
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.
Oncogene 2002;21(42):6446-57.
2002: Neil J Toft; Lucy J Curtis; Owen J Sansom; Andrea L Leitch; Andrew H Wyllie; Hein te Riele; Mark J Arends; Alan R Clarke
Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.
Oncogene 2002;21(41):6299-306.
2002: Catherine B Millar; Jacky Guy; Owen J Sansom; Jim Selfridge; Eilidh MacDougall; Brian Hendrich; Peter D Keightley; Stefan M Bishop; Alan R Clarke; Adrian Bird
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.
Science (New York, N.Y.) 2002;297(5580):403-5.
2002: Jonathan P Coe; Irfan Rahman; Nathalie Sphyris; Alan R Clarke; David J Harrison
Glutathione and p53 independently mediate responses against oxidative stress in ES cells.
Free radical biology & medicine 2002;32(2):187-96.
2001: Owen J Sansom; Lesley Stark; Malcolm G Dunlop; Alan R Clarke
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.
Cancer research 2001;61(19):7060-4.
2001: Owen J Sansom; Neil J Toft; Douglas J Winton; Alan R Clarke
Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.
Oncogene 2001;20(27):3580-4.
2000: RS Chapman; E K Duff; PC Lourenco; Elizabeth Tonner; David J Flint; Alan R Clarke; CJ Watson
A novel role for IRF-1 as a suppressor of apoptosis.
Oncogene 2000;19(54):6386-91.
2000: Owen J Sansom; Alan R Clarke
P53 null mice: damaging the hypothesis?
Mutation research 2000;452(2):149-62.
2000: Neil J Toft; Owen J Sansom; R A Brookes; Mark J Arends; M Wood; G P Margison; Douglas J Winton; Alan R Clarke
In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.
Carcinogenesis 2000;21(4):593-8.
2000: Alan R Clarke
Manipulating the germline: its impact on the study of carcinogenesis.
Carcinogenesis 2000;21(3):435-41.
2000: RS Chapman; PC Lourenco; Elizabeth Tonner; David J Flint; S Selbert; K Takeda; S Akira; Alan R Clarke; CJ Watson
The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3.
Advances in experimental medicine and biology 2000;480():129-38.
1999: R Kongkanuntn; Vivien J Bubb; Owen J Sansom; Andrew H Wyllie; David J Harrison; Alan R Clarke
Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.
Oncogene 1999;18(51):7219-25.
1999: RS Chapman; PC Lourenco; Elizabeth Tonner; David J Flint; S Selbert; K Takeda; S Akira; Alan R Clarke; CJ Watson
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.
Genes & development 1999;13(19):2604-16.
1999: Andrew H Wyllie; Christopher O C Bellamy; Vivien J Bubb; Alan R Clarke; S Corbet; L Curtis; David J Harrison; Martin L Hooper; Neil J Toft; S Webb; CC Bird
Apoptosis and carcinogenesis.
British journal of cancer 1999;80 Suppl 1():34-7.
1999: Neil J Toft; Douglas J Winton; J Kelly; L A Howard; M Dekker; Hein te Riele; Mark J Arends; Andrew H Wyllie; G P Margison; Alan R Clarke
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3911-5.
1999: S W Corbet; Alan R Clarke; S Gledhill; Andrew H Wyllie
P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells.
Oncogene 1999;18(8):1537-44.
1998: E K Duff; Alan R Clarke
Smad4 (DPC4)--a potent tumour suppressor?
British journal of cancer 1998;78(12):1615-9.
1998: Stefan Selbert; D J Bentley; David W Melton; Dominic Rannie; P Lourenço; C J Watson; Alan R Clarke
Efficient BLG-Cre mediated gene deletion in the mammary gland.
Transgenic research 1998;7(5):387-96.
1998: sandrine prost; Christopher O C Bellamy; Alan R Clarke; Andrew H Wyllie; David J Harrison
p53-independent DNA repair and cell cycle arrest in embryonic stem cells.
FEBS letters 1998;425(3):499-504.
1998: Neil J Toft; Mark J Arends; Andrew H Wyllie; Alan R Clarke
No female embryonic lethality in mice nullizygous for Msh2 and p53.
Nature genetics 1998;18(1):17.
1997: S Pells; M Divjak; P Romanowski; HL Impey; Nicholas Hawkins; Alan R Clarke; Martin L Hooper; D J Williamson
Developmentally-regulated expression of murine K-ras isoforms.
Oncogene 1997;15(15):1781-6.
1997: Christopher O C Bellamy; Alan R Clarke; Andrew H Wyllie; David J Harrison
p53 Deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(7):591-9.
1997: Alan R Clarke; L A Howard; David J Harrison; Douglas J Winton
p53, mutation frequency and apoptosis in the murine small intestine.
Oncogene 1997;14(17):2015-8.
1997: R D Malcomson; Alan R Clarke; A Peter; S B Coutts; S E Howie; David J Harrison
Apoptosis induced by gamma-irradiation, but not CD4 ligation, of peripheral T lymphocytes in vivo is p53-dependent.
The Journal of pathology 1997;181(2):166-71.
1997: E A Lovejoy; Alan R Clarke; David J Harrison
Animal models and the molecular pathology of cancer.
The Journal of pathology 1997;181(2):130-5.
1997: S K Lyons; Alan R Clarke
Apoptosis and carcinogenesis.
British medical bulletin 1997;53(3):554-69.
1996: H Wallace; Alan R Clarke; David J Harrison; M L Hooper; JO Bishop
Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.
Oncogene 1996;13(1):55-61.
1996: Alan R Clarke
The role of the tumor suppressor genes p53 and Rb-1 in development and cell death.
Birth defects original article series 1996;30(1):261-8.
1995: Alan R Clarke; M C Cummings; David J Harrison
Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.
Oncogene 1995;11(9):1913-20.
1995: J F Armstrong; M H Kaufman; David J Harrison; Alan R Clarke
High-frequency developmental abnormalities in p53-deficient mice.
Current biology : CB 1995;5(8):931-6.
1995: Alan R Clarke
Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53.
Cancer metastasis reviews 1995;14(2):125-48.
1995: David J Harrison; M L Hooper; J F Armstrong; Alan R Clarke
Effects of heterozygosity for the Rb-1t19neo allele in the mouse.
Oncogene 1995;10(8):1615-20.
1994: Alan R Clarke; S Gledhill; M L Hooper; CC Bird; Andrew H Wyllie
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.
Oncogene 1994;9(6):1767-73.
1994: Alan R Clarke
Murine genetic models of human disease.
Current opinion in genetics & development 1994;4(3):453-60.
1994: Andrew H Wyllie; P J Carder; Alan R Clarke; K J Cripps; S Gledhill; M F Greaves; S Griffiths; David J Harrison; M L Hooper; Richard G M Morris
Apoptosis in carcinogenesis: the role of p53.
Cold Spring Harbor symposia on quantitative biology 1994;59():403-9.
1993: K Samuel; Alan R Clarke; J D Ansell; M L Hooper
Age-dependent selection against hypoxanthine phosphoribosyl transferase-deficient cells in mouse haematopoiesis.
Development (Cambridge, England) 1993;118(3):859-63.
1993: Alan R Clarke; C A Purdie; David J Harrison; Richard G M Morris; CC Bird; M L Hooper; Andrew H Wyllie
Thymocyte apoptosis induced by p53-dependent and independent pathways.
Nature 1993;362(6423):849-52.
1992: Alan R Clarke; E R Maandag; M van Roon; N M van der Lugt; Martin van der Valk; M L Hooper; Anton Berns; Hein te Riele
Requirement for a functional Rb-1 gene in murine development.
Nature 1992;359(6393):328-30.
1992: Julia R Dorin; P Dickinson; Eric W F W Alton; Stephen N Smith; D M Geddes; B J Stevenson; W L Kimber; S Fleming; Alan R Clarke; M L Hooper
Cystic fibrosis in the mouse by targeted insertional mutagenesis.
Nature 1992;359(6392):211-5.
1992: Julia R Dorin; P Dickinson; E Emslie; Alan R Clarke; L Dobbie; M L Hooper; Stephanie Halford; B J Wainwright; David J Porteous
Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells.
Transgenic research 1992;1(2):101-5.
1991: D J Williamson; John Sharkey; Alan R Clarke; A Jamieson; Gordon W Arbuthnott; P Kelly; David W Melton; M L Hooper
Analysis of forebrain dopaminergic pathways in HPRT-mice.
Advances in experimental medicine and biology 1991;309B():269-72.
1989: S Thompson; Alan R Clarke; A M Pow; M L Hooper; David W Melton
Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.
Cell 1989;56(2):313-21.