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Christine Clarke

Research Profile

Chemicals & Drugs

Disorders

Breast Neoplasms

Anatomy

Physiology

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Publications

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George E O Muscat; Mark A Ragan; Evan R Simpson; Wayne D Tilley; Karen Byth; Colin Clyne; Melissa J Davis; Natalie A Eriksson; Peter J Fuller; John W Funder; Dinny Graham; Shalini Jindal; Elizabeth Kuczek; Peter J Leedman; Sherene Loi; Christine L Clarke
Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer.
Matloob Khushi; Jane E Carpenter; Diego Alonso de Marcos; Georgina Edwards; J Dinny Graham; Christine L Clarke
Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information.
H N Hilton; Lily I Huschtscha; S Kantimm; Patricia A Mote; N Santucci; D Cloosterman; J Dinny Graham; Christine L Clarke
Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.

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All Publications

2013: George E O Muscat; Mark A Ragan; Evan R Simpson; Wayne D Tilley; Karen Byth; Colin Clyne; Melissa J Davis; Natalie A Eriksson; Peter J Fuller; John W Funder; Dinny Graham; Shalini Jindal; Elizabeth Kuczek; Peter J Leedman; Sherene Loi; Christine L Clarke
Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer.
Molecular endocrinology (Baltimore, Md.) 2013;27(2):350-65.
2013: Matloob Khushi; Jane E Carpenter; Diego Alonso de Marcos; Georgina Edwards; J Dinny Graham; Christine L Clarke
Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information.
Diagnostic pathology 2013;8():22.
2012: H N Hilton; Lily I Huschtscha; S Kantimm; Patricia A Mote; N Santucci; D Cloosterman; J Dinny Graham; Christine L Clarke
Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.
Molecular and cellular endocrinology 2012;361(1-2):191-201.
2012: Matloob Khushi; Rosemary L Balleine; Jane E Carpenter; Christine L Clarke
Development of a data entry auditing protocol and quality assurance for a tissue bank database.
Cell and tissue banking 2012;13(1):9-13.
2011: Catherine Emmanuel; Natalie Gava; Catherine Kennedy; Rosemary L Balleine; Raghwa Sharma; Gerard Wain; Alison Brand; Russell Hogg; Dariush Etemadmoghadam; Joshy George; Michael J Birrer; Christine L Clarke; Georgia Chenevix-Trench; David D L Bowtell; Paul R Harnett; Anna deFazio
Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.
PloS one 2011;6(3):e17617.
2010: Nirmala Pathmanathan; Elizabeth Salisbury; Pamela J Provan; A Michael Bilous; Karen Byth; Jane S Milliken; Christine L Clarke; Rosemary L Balleine
A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast.
Pathology 2010;42(1):28-36.
2009: J Dinny Graham; Patricia A Mote; Usha Salagame; Rosemary L Balleine; Lily I Huschtscha; Christine L Clarke
Hormone-responsive model of primary human breast epithelium.
Journal of mammary gland biology and neoplasia 2009;14(4):367-79.
2009: J Dinny Graham; Patricia A Mote; Usha Salagame; Jessica H van Dijk; Rosemary L Balleine; Lily I Huschtscha; Roger R Reddel; Christine L Clarke
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast.
Endocrinology 2009;150(7):3318-26.
2009: J Dinny Graham; Adrienne R Hanson; Amanda J Croft; Archa Fox; Christine L Clarke
Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):546-56.
2009: Katherine M Scarpin; J Dinny Graham; Patricia A Mote; Christine L Clarke
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
Nuclear receptor signaling 2009;7():e009.
2007: Howard Gurney; Mark Wong; Rosemary L Balleine; Laurent P Rivory; Andrew J McLachlan; Janelle Hoskins; Nicholas Wilcken; Christine L Clarke; Graham J Mann; Michael Collins; S-E Delforce; K Lynch; H Schran
Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype.
Clinical pharmacology and therapeutics 2007;82(1):33-40.
2007: Patricia A Mote; J Dinny Graham; Christine L Clarke
Progesterone receptor isoforms in normal and malignant breast.
Ernst Schering Foundation symposium proceedings 2007;(1):77-107.
2007: Rebecca L Arnett-Mansfield; J Dinny Graham; Adrienne R Hanson; Patricia A Mote; anne Gompel; Lyndee L Scurr; Natalie Gava; Anna de Fazio; Christine L Clarke
Focal subnuclear distribution of progesterone receptor is ligand dependent and associated with transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):14-29.
2006: L N Cowell; J Dinny Graham; A H Bouton; Christine L Clarke; Geraldine M O'Neill
Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.
Oncogene 2006;25(58):7597-607.
2006: Patricia A Mote; Rebecca L Arnett-Mansfield; Natalie Gava; Anna deFazio; Biserka Mulac-Jericevic; Orla M Conneely; Christine L Clarke
Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle.
Endocrinology 2006;147(12):5503-12.
2006: Mark Wong; Rosemary L Balleine; Elaine Y L Blair; Andrew J McLachlan; Stephen P Ackland; Madhu B Garg; Scott Evans; David Farlow; Michael Collins; Laurent P Rivory; Janelle Hoskins; Graham J Mann; Christine L Clarke; Howard Gurney
Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(16):2448-55.
2006: Graham J Mann; Heather Thorne; Rosemary L Balleine; Phyllis N Butow; Christine L Clarke; Edward Edkins; Gerda M Evans; Sián Fereday; Eric Haan; Michael Gattas; Graham G Giles; Jack Goldblatt; John L Hopper; Judy Kirk; Jennifer A Leary; Geoffrey J Lindeman; Eveline Niedermayr; Kelly-Anne Phillips; Sandra Picken; Gulietta M Pupo; Christobel Saunders; Clare L Scott; Amanda B Spurdle; Graeme Suthers; Katherine Tucker; Georgia Chenevix-Trench
Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource.
Breast cancer research : BCR 2006;8(1):R12.
2005: J Dinny Graham; Melissa L Yager; Hazel D Hill; Karen Byth; Geraldine M O'Neill; Christine L Clarke
Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2005;19(11):2713-35.
2005: Lucy R Webster; A Michael Bilous; L Willis; Karen Byth; F C Burgemeister; E L C Salisbury; Christine L Clarke; Rosemary L Balleine
Histopathologic indicators of breast cancer biology: insights from population mammographic screening.
British journal of cancer 2005;92(8):1366-71.
2005: Morteza Aghmesheh; Lyndal Edwards; Christine L Clarke; Karen Byth; Benita S Katzenellenbogen; Pamela J Russell; Michael Friedlander; Katherine M Tucker; Anna de Fazio
Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas.
Gynecologic oncology 2005;97(1):16-25.
2005: Marianne J van den Heuvel; Sirirak Chantakru; Xie Xuemei; Sharon S Evans; Francis Tekpetey; Patricia A Mote; Christine L Clarke; B Anne Croy
Trafficking of circulating pro-NK cells to the decidualizing uterus: regulatory mechanisms in the mouse and human.
Immunological investigations 2005;34(3):273-93.
2005: Mark Wong; Scott Evans; Laurent P Rivory; Janelle Hoskins; Graham J Mann; David Farlow; Christine L Clarke; Rosemary L Balleine; Howard Gurney
Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer.
Clinical pharmacology and therapeutics 2005;77(1):33-42.
2004: Natalie Gava; Christine L Clarke; Karen Byth; Rebecca L Arnett-Mansfield; Anna deFazio
Expression of progesterone receptors A and B in the mouse ovary during the estrous cycle.
Endocrinology 2004;145(7):3487-94.
2004: Mark Wong; Rosemary L Balleine; Michael Collins; Christopher Liddle; Christine L Clarke; Howard Gurney
CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy.
Clinical pharmacology and therapeutics 2004;75(6):529-38.
2004: Rosemary L Balleine; Peter J Earls; Lucy R Webster; Patricia A Mote; Anna deFazio; Paul R Harnett; Christine L Clarke
Expression of progesterone receptor A and B isoforms in low-grade endometrial stromal sarcoma.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2004;23(2):138-44.
2004: Rebecca L Arnett-Mansfield; Anna deFazio; Patricia A Mote; Christine L Clarke
Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium.
The Journal of clinical endocrinology and metabolism 2004;89(3):1429-42.
2004: Patricia A Mote; Jennifer A Leary; Kelly A Avery; Kerstin Sandelin; Georgia Chenevix-Trench; Judy A Kirk; Christine L Clarke
Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A.
Genes, chromosomes & cancer 2004;39(3):236-48.
2004: Eileen Mary McGowan; Sonia Saad; Linda Bendall; Kenneth F Bradstock; Christine L Clarke
Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts.
Breast cancer research and treatment 2004;83(3):211-20.
2003: Eileen Mary McGowan; Ron P Weinberger; J Dinny Graham; H D Hill; J A I Hughes; Geraldine M O'Neill; Christine L Clarke
Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels.
Journal of molecular endocrinology 2003;31(2):241-53.
2002: Catherine Kennedy; Karen Byth; Christine L Clarke; Anna deFazio
Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate.
Molecular cancer therapeutics 2002;1(12):1025-33.
2002: Patricia A Mote; S Bartow; N Tran; Christine L Clarke
Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis.
Breast cancer research and treatment 2002;72(2):163-72.
2002: J Dinny Graham; Christine L Clarke
Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells.
Breast cancer research : BCR 2002;4(5):187-90.
2001: Rosemary L Balleine; K E Humphrey; Christine L Clarke
Tumour banks: providing human tissue for cancer research.
The Medical journal of Australia 2001;175(6):293-4.
2001: Patricia A Mote; J F Johnston; Tommi Manninen; P Tuohimaa; Christine L Clarke
Detection of progesterone receptor forms A and B by immunohistochemical analysis.
Journal of clinical pathology 2001;54(8):624-30.
2001: Rebecca L Arnett-Mansfield; Anna deFazio; G V Wain; R C Jaworski; K Byth; Patricia A Mote; Christine L Clarke
Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium.
Cancer research 2001;61(11):4576-82.
2000: T Davis; C Kennedy; Yoke-Eng Chiew; Christine L Clarke; Anna deFazio
Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4334-42.
2000: Rosemary L Balleine; M S Fejzo; P Sathasivam; P Basset; Christine L Clarke; Jennifer A Byrne
The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma.
Genes, chromosomes & cancer 2000;29(1):48-57.
2000: Patricia A Mote; Rosemary L Balleine; Eileen Mary McGowan; Christine L Clarke
Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma.
Human reproduction (Oxford, England) 2000;15 Suppl 3():48-56.
1999: Eileen Mary McGowan; Christine L Clarke
Effect of overexpression of progesterone receptor A on endogenous progestin-sensitive endpoints in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 1999;13(10):1657-71.
1999: Patricia A Mote; Rosemary L Balleine; Eileen Mary McGowan; Christine L Clarke
Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle.
The Journal of clinical endocrinology and metabolism 1999;84(8):2963-71.
1999: SM Hunt; Christine L Clarke
Expression and hormonal regulation of the Sox4 gene in mouse female reproductive tissues.
Biology of reproduction 1999;61(2):476-81.
1999: J Dinny Graham; SM Hunt; N Tran; Christine L Clarke
Regulation of the expression and activity by progestins of a member of the SOX gene family of transcriptional modulators.
Journal of molecular endocrinology 1999;22(3):295-304.
1999: Rosemary L Balleine; Christine L Clarke
Expression of the oestrogen responsive protein pS2 in human breast cancer.
Histology and histopathology 1999;14(2):571-8.
1999: Rosemary L Balleine; SM Hunt; Christine L Clarke
Coexpression of alternatively spliced estrogen and progesterone receptor transcripts in human breast cancer.
The Journal of clinical endocrinology and metabolism 1999;84(4):1370-7.
1999: Rosemary L Balleine; M J Earl; M L Greenberg; Christine L Clarke
Absence of progesterone receptor associated with secondary breast cancer in postmenopausal women.
British journal of cancer 1999;79(9-10):1564-71.
1998: Patricia A Mote; Jennifer A Leary; Christine L Clarke
Immunohistochemical detection of progesterone receptors in archival breast cancer.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1998;73(3):117-27.
1998: E M Jarvis; Judy A Kirk; Christine L Clarke
Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype.
Cancer genetics and cytogenetics 1998;101(2):109-15.
1998: C Yeates; SM Hunt; Rosemary L Balleine; Christine L Clarke
Characterization of a truncated progesterone receptor protein in breast tumors.
The Journal of clinical endocrinology and metabolism 1998;83(2):460-7.
1997: J Dinny Graham; Rosemary L Balleine; J S Milliken; A Michael Bilous; Christine L Clarke
Expression of osteonectin mRNA in human breast tumours is inversely correlated with oestrogen receptor content.
European journal of cancer (Oxford, England : 1990) 1997;33(10):1654-60.
1997: J Dinny Graham; Christine L Clarke
Physiological action of progesterone in target tissues.
Endocrine reviews 1997;18(4):502-19.
1997: David R H Christie; Judy A Kirk; Christine L Clarke; J Boyages
Association of hereditary angioedema and hereditary breast cancer.
Cancer genetics and cytogenetics 1997;95(2):159-62.
1996: J Dinny Graham; C Yeates; Rosemary L Balleine; S S Harvey; J S Milliken; A M Bilous; Christine L Clarke
Progesterone receptor A and B protein expression in human breast cancer.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):93-8.
1995: J Dinny Graham; S D Roman; Eileen Mary McGowan; Robert L Sutherland; Christine L Clarke
Preferential stimulation of human progesterone receptor B expression by estrogen in T-47D human breast cancer cells.
The Journal of biological chemistry 1995;270(51):30693-700.
1995: J Dinny Graham; C Yeates; Rosemary L Balleine; S S Harvey; J S Milliken; A M Bilous; Christine L Clarke
Characterization of progesterone receptor A and B expression in human breast cancer.
Cancer research 1995;55(21):5063-8.
1993: S D Roman; Christopher J Ormandy; DL Manning; Roger W Blamey; Robert I Nicholson; Robert L Sutherland; Christine L Clarke
Estradiol induction of retinoic acid receptors in human breast cancer cells.
Cancer research 1993;53(24):5940-5.
1992: Christopher J Ormandy; J Graham; P A Kelly; Christine L Clarke; Robert L Sutherland
The effect of progestins on prolactin receptor gene transcription in human breast cancer cells.
DNA and cell biology 1992;11(10):721-6.
1992: S D Roman; Christine L Clarke; R E Hall; I E Alexander; Robert L Sutherland
Expression and regulation of retinoic acid receptors in human breast cancer cells.
Cancer research 1992;52(8):2236-42.
1992: Christopher J Ormandy; Christine L Clarke; P A Kelly; Robert L Sutherland
Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells.
International journal of cancer. Journal international du cancer 1992;50(5):777-82.
1991: Christine L Clarke; J Graham; S D Roman; Robert L Sutherland
Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D.
The Journal of biological chemistry 1991;266(28):18969-75.
1990: R E Hall; C S Lee; I E Alexander; John Shine; Christine L Clarke; Robert L Sutherland
Steroid hormone receptor gene expression in human breast cancer cells: inverse relationship between oestrogen and glucocorticoid receptor messenger RNA levels.
International journal of cancer. Journal international du cancer 1990;46(6):1081-7.
1990: Christine L Clarke; S D Roman; J Graham; M Koga; Robert L Sutherland
Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D.
The Journal of biological chemistry 1990;265(21):12694-700.
1990: Christopher J Ormandy; Christine L Clarke; Robert L Sutherland
Solubilization and characterization of a lactogenic receptor from human placental chorion membranes.
Journal of cellular biochemistry 1990;43(1):1-15.
1990: Christine L Clarke; Robert L Sutherland
Progestin regulation of cellular proliferation.
Endocrine reviews 1990;11(2):266-301.
1989: I E Alexander; Christine L Clarke; John Shine; Robert L Sutherland
Progestin inhibition of progesterone receptor gene expression in human breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1377-86.
1988: Robert L Sutherland; R E Hall; G Y Pang; Elizabeth A Musgrove; Christine L Clarke
Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells.
Cancer research 1988;48(18):5084-91.