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Iain Clarke

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Iain J Clarke; Alain Caraty
Kisspeptin and seasonality of reproduction.
Julie-Ann P De Bond; Qun Li; Robert P Millar; Iain J Clarke; Jeremy T Smith
Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males.
Scott D Clarke; Roger G Evans; Iain J Clarke; Alexandra Rao; BA Henry
Differential effects of acute and chronic estrogen treatment on thermogenic and metabolic pathways in ovariectomized sheep.

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All Publications

2013: Iain J Clarke; Alain Caraty
Kisspeptin and seasonality of reproduction.
Advances in experimental medicine and biology 2013;784():411-30.
2013: Julie-Ann P De Bond; Qun Li; Robert P Millar; Iain J Clarke; Jeremy T Smith
Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males.
PloS one 2013;8(2):e57972.
2013: Scott D Clarke; Roger G Evans; Iain J Clarke; Alexandra Rao; BA Henry
Differential effects of acute and chronic estrogen treatment on thermogenic and metabolic pathways in ovariectomized sheep.
Endocrinology 2013;154(1):184-92.
2012: Scott D Clarke; Roger G Evans; Fahri Fahri; Zane B Andrews; Robert Bischof; Iain J Clarke; Kevin Lee; BA Henry
Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;303(10):R1071-9.
2012: Elaine S Adler; Iain J Clarke; DR Grattan; Jacob H Hollis; Brian J Oldfield
Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(45):15913-21.
2012: Jeremy T Smith; Johannes D Veldhuis; I Ross Young; Iain J Clarke
Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system.
Endocrinology 2012;153(7):3368-75.
2012: Qun Li; Alexandra Roa; Iain J Clarke; Jeremy T Smith
Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor.
Neuroendocrinology 2012;96(3):212-21.
2012: Iain J Clarke; Claude Fabre-Nys; Beng Ti Ang; Alain Caraty; Louiza Chan; Keefe Chng; BA Henry; Robert P Millar; Brian J Oldfield; Ika Puspita Sari; Jeremy T Smith; Aneta Stefanidis; Gregory S Fraley
Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding.
Neuroendocrinology 2012;95(4):305-16.
2011: Q Li; Alda Pereira; A Rao; Iain J Clarke; J T Smith
Kisspeptin cells in the ovine arcuate nucleus express prolactin receptor but not melatonin receptor.
Journal of neuroendocrinology 2011;23(10):871-82.
2011: Iain J Clarke
Control of GnRH secretion: one step back.
Frontiers in neuroendocrinology 2011;32(3):367-75.
2011: BA Henry; Alexandra Rao; Zane B Andrews; Iain J Clarke
Central leptin activates mitochondrial function and increases heat production in skeletal muscle.
Endocrinology 2011;152(7):2609-18.
2011: Jeremy T Smith; Qun Li; Kai Sing Yap; Muhammad Shahab; Antonia K Roseweir; robert p millar; Iain J Clarke
Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence.
Endocrinology 2011;152(3):1001-12.
2011: M M Papargiris; Elizabeth T A Rivalland; Iain J Clarke; J T Smith; Alda Pereira; Alan J Tilbrook
Evidence that RF-amide related peptide-3 is not a mediator of the inhibitory effects of psychosocial stress on gonadotrophin secretion in ovariectomised ewes.
Journal of neuroendocrinology 2011;23(3):208-15.
2010: Jeremy T Smith; Muhammad Shahab; Alda Pereira; K-Y Francis Pau; Iain J Clarke
Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate.
Biology of reproduction 2010;83(4):568-77.
2010: BA Henry; Dominique Blache; Alexandra Rao; Iain J Clarke; Shane K Maloney
Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(3):R907-17.
2010: Jeremy T Smith; Iain J Clarke
Seasonal breeding as a neuroendocrine model for puberty in sheep.
Molecular and cellular endocrinology 2010;324(1-2):102-9.
2010: Jeremy T Smith; Iain J Clarke
Gonadotropin inhibitory hormone function in mammals.
Trends in endocrinology and metabolism: TEM 2010;21(4):255-60.
2010: Iain J Clarke
Whatever way weight goes, inflammation shows.
Endocrinology 2010;151(3):846-8.
2010: Alda Pereira; John A Rawson; A Jakubowska; Iain J Clarke
Estradiol-17beta-responsive A1 and A2 noradrenergic cells of the brain stem project to the bed nucleus of the stria terminalis in the ewe brain: a possible route for regulation of gonadotropin releasing hormone cells.
Neuroscience 2010;165(3):758-73.
2010: Chantacha Anukulkitch; Alexandra Rao; Alda Pereira; John McEwan; Iain J Clarke
Expression of genes for appetite-regulating peptides in the hypothalamus of genetically selected lean and fat sheep.
Neuroendocrinology 2010;91(3):223-38.
2010: Kathryn Backholer; Marissa Bowden; Kevin Matthew Gamber; Christian Bjørbaek; Javed Iqbal; Iain J Clarke
Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes.
Neuroendocrinology 2010;91(1):27-40.
2010: Iain J Clarke; BA Henry
Targeting energy expenditure in muscle as a means of combating obesity.
Clinical and experimental pharmacology & physiology 2010;37(1):121-4.
2009: Kathryn Backholer; Jeremy Smith; Iain J Clarke
Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe.
Endocrinology 2009;150(12):5488-97.
2009: J T Smith; Q Li; Alda Pereira; Iain J Clarke
Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge.
Endocrinology 2009;150(12):5530-8.
2009: Ika P Sari; Alexandra Rao; Jeremy T Smith; Alan J Tilbrook; Iain J Clarke
Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes.
Endocrinology 2009;150(12):5549-56.
2009: Javed Iqbal; Olivier Latchoumanin; Ika P Sari; Richard J Lang; Harold A Coleman; Helena C Parkington; Iain J Clarke
Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release.
Endocrinology 2009;150(9):4213-20.
2009: Yue Qi; Brian J Oldfield; Iain J Clarke
Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction.
Journal of neuroendocrinology 2009;21(8):690-7.
2009: Iain J Clarke; Y Qi; I Puspita Sari; Jeremy T Smith
Evidence that RF-amide related peptides are inhibitors of reproduction in mammals.
Frontiers in neuroendocrinology 2009;30(3):371-8.
2009: B N Pierce; Iain J Clarke; Anne I Turner; Elizabeth T A Rivalland; Alan J Tilbrook
Cortisol disrupts the ability of estradiol-17beta to induce the LH surge in ovariectomized ewes.
Domestic animal endocrinology 2009;36(4):202-8.
2009: Chantacha Anukulkitch; Alexandra Rao; Frank R Dunshea; Iain J Clarke
A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals a close relationship between adiposity and melanin concentrating hormone expression.
Domestic animal endocrinology 2009;36(3):138-51.
2009: Jeremy T Smith; Sofie N H Saleh; Iain J Clarke
Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe.
Neuroendocrinology 2009;90(3):283-91.
2009: Yue Qi; M R Namavar; Javed Iqbal; Brian J Oldfield; Iain J Clarke
Characterization of the projections to the hypothalamic paraventricular and periventricular nuclei in the female sheep brain, using retrograde tracing and immunohistochemistry.
Neuroendocrinology 2009;90(1):31-53.
2009: Iain J Clarke; Jeremy T Smith; Alain Caraty; Robert L Goodman; Michael N Lehman
Kisspeptin and seasonality in sheep.
Peptides 2009;30(1):154-63.
2009: Amy E Oakley; Kellie M Breen; Iain J Clarke; Fred J Karsch; Elizabeth R Wagenmaker; Alan J Tilbrook
Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids.
Endocrinology 2009;150(1):341-9.
2009: B N Pierce; Catherine A Stackpole; Kellie M Breen; Iain J Clarke; Fred J Karsch; Elizabeth T A Rivalland; Anne I Turner; DJ Caddy; E R Wagenmaker; A E Oakley; Alan J Tilbrook
Estradiol enables cortisol to act directly upon the pituitary to suppress pituitary responsiveness to GnRH in sheep.
Neuroendocrinology 2009;89(1):86-97.
2008: Iain J Clarke; Ika P Sari; Yue Qi; Jeremy T Smith; Helena C Parkington; Takayoshi Ubuka; Javed Iqbal; Qun Li; Alan Tilbrook; Kevin Morgan; Adam J Pawson; Kazuyoshi Tsutsui; Robert P Millar; George E Bentley
Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.
Endocrinology 2008;149(11):5811-21.
2008: Jeremy T Smith; Lique M Coolen; Lance J Kriegsfeld; Ika P Sari; Mohammad R Jaafarzadehshirazi; Matthew Maltby; Katherine Bateman; Robert L Goodman; Alan J Tilbrook; Takayoshi Ubuka; George E Bentley; Iain J Clarke; Michael N Lehman
Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep.
Endocrinology 2008;149(11):5770-82.
2008: B N Pierce; PH Hemsworth; E T A Rivalland; E R Wagenmaker; A D Morrissey; M M Papargiris; Iain J Clarke; Fred J Karsch; Anne I Turner; Alan J Tilbrook
Psychosocial stress suppresses attractivity, proceptivity and pulsatile LH secretion in the ewe.
Hormones and behavior 2008;54(3):424-34.
2008: BA Henry; Iain J Clarke
Adipose tissue hormones and the regulation of food intake.
Journal of neuroendocrinology 2008;20(6):842-9.
2008: Christopher J Scott; Iain J Clarke; Alan J Tilbrook
The effect of testosterone and season on prodynorphin messenger RNA expression in the preoptic area-hypothalamus of the ram.
Domestic animal endocrinology 2008;34(4):440-50.
2008: Belinda A Henry; Frank R Dunshea; Merryn Gould; Iain J Clarke
Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration.
Endocrinology 2008;149(4):2019-26.
2008: J T Smith; Alexandra Rao; Alda Pereira; Alain Caraty; R P Millar; Iain J Clarke
Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo.
Endocrinology 2008;149(4):1951-9.
2008: Alan J Tilbrook; Elizabeth A T Rivalland; Anne I Turner; Gavin Lambert; Iain J Clarke
Responses of the hypothalamopituitary adrenal axis and the sympathoadrenal system to isolation/restraint stress in sheep of different adiposity.
Neuroendocrinology 2008;87(4):193-205.
2008: Iain J Clarke
Models of 'obesity' in large animals and birds.
Frontiers of hormone research 2008;36():107-17.
2008: Yue Qi; Javed Iqbal; Brian J Oldfield; Iain J Clarke
Neural connectivity in the mediobasal hypothalamus of the sheep brain.
Neuroendocrinology 2008;87(2):91-112.
2007: Robert L Goodman; Michael N Lehman; Jeremy T Smith; Lique M Coolen; Cleusa V R de Oliveira; Mohammad R Jafarzadehshirazi; Alda Pereira; Javed Iqbal; Alain Caraty; Philippe Ciofi; Iain J Clarke
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.
Endocrinology 2007;148(12):5752-60.
2007: Javed Iqbal; Olivier Latchoumanin; Iain J Clarke
Rapid in vivo effects of estradiol-17beta in ovine pituitary gonadotropes are displayed by phosphorylation of extracellularly regulated kinase, serine/threonine kinase, and 3',5'-cyclic adenosine 5'-monophosphate-responsive element-binding protein.
Endocrinology 2007;148(12):5794-802.
2007: L A Szymanski; Jill E Schneider; M I Friedman; H Ji; Y Kurose; Dominique Blache; Alexandra Rao; Frank R Dunshea; Iain J Clarke
Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes.
Journal of neuroendocrinology 2007;19(6):449-60.
2007: Elizabeth T A Rivalland; Iain J Clarke; Anne I Turner; Sueli Pompolo; Alan J Tilbrook
Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep.
Neuroscience 2007;145(3):1048-58.
2007: J T Smith; Iain J Clarke
Kisspeptin expression in the brain: catalyst for the initiation of puberty.
Reviews in endocrine & metabolic disorders 2007;8(1):1-9.
2007: Jeremy T Smith; Colin M Clay; Alain Caraty; Iain J Clarke
KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season.
Endocrinology 2007;148(3):1150-7.
2007: Chantacha Anukulkitch; Alexandra Rao; Frank R Dunshea; Dominique Blache; Gerald A Lincoln; Iain J Clarke
Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammal.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(1):R242-52.
2006: Catherine A Stackpole; Iain J Clarke; Kellie M Breen; Anne I Turner; Fred J Karsch; Alan J Tilbrook
Sex difference in the suppressive effect of cortisol on pulsatile secretion of luteinizing hormone in sheep.
Endocrinology 2006;147(12):5921-31.
2006: KM Estrada; C M Clay; Sueli Pompolo; J T Smith; Iain J Clarke
Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback.
Journal of neuroendocrinology 2006;18(10):806-9.
2006: Alan J Tilbrook; Iain J Clarke
Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress.
Frontiers in neuroendocrinology 2006;27(3):285-307.
2006: Alan J Tilbrook; Anne I Turner; M D Ibbott; Iain J Clarke
Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes: effect of the presence of the lamb and suckling.
Endocrinology 2006;147(7):3501-9.
2006: Iain J Clarke; Christopher J Scott; Alda Pereira; Sueli Pompolo
The role of noradrenaline in the generation of the preovulatory LH surge in the ewe.
Domestic animal endocrinology 2006;30(4):260-75.
2006: Sueli Pompolo; Alda Pereira; KM Estrada; Iain J Clarke
Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain.
Endocrinology 2006;147(2):804-10.
2006: Elizabeth T A Rivalland; Alan J Tilbrook; Anne I Turner; Javed Iqbal; Sueli Pompolo; Iain J Clarke
Projections to the preoptic area from the paraventricular nucleus, arcuate nucleus and the bed nucleus of the stria terminalis are unlikely to be involved in stress-induced suppression of GnRH secretion in sheep.
Neuroendocrinology 2006;84(1):1-13.
2006: Javed Iqbal; Yohei Kurose; Benedict J Canny; Iain J Clarke
Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep.
Endocrinology 2006;147(1):510-9.
2005: Jillian H Broadbear; B N Pierce; Iain J Clarke; Benedict J Canny
Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep.
Journal of neuroendocrinology 2005;17(12):804-10.
2005: Javed Iqbal; Tim R Manley; Philippe Ciofi; Iain J Clarke
Reduction in adiposity affects the extent of afferent projections to growth hormone-releasing hormone and somatostatin neurons and the degree of colocalization of neuropeptides in growth hormone-releasing hormone and somatostatin cells of the ovine hypothalamus.
Endocrinology 2005;146(11):4776-85.
2005: Iain J Clarke; Sueli Pompolo
Synthesis and secretion of GnRH.
Animal reproduction science 2005;88(1-2):29-55.
2005: Javed Iqbal; T R Manley; Yue Qi; M R Namavar; Iain J Clarke
Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep.
Journal of neuroendocrinology 2005;17(6):341-52.
2005: Yohei Kurose; Javed Iqbal; Alexandra Rao; Y Murata; Yoshihisa Hasegawa; Yoshiaki Terashima; Masayasu Kojima; Kenji Kangawa; Iain J Clarke
Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means.
Journal of neuroendocrinology 2005;17(6):331-40.
2005: Iain J Clarke; Vicky A Tobin; Sueli Pompolo; Alda Pereira
Effects of changing gonadotropin-releasing hormone pulse frequency and estrogen treatment on levels of estradiol receptor-alpha and induction of Fos and phosphorylated cyclic adenosine monophosphate response element binding protein in pituitary gonadotropes: studies in hypothalamo-pituitary disconnected ewes.
Endocrinology 2005;146(3):1128-37.
2005: Iain J Clarke; Kathryn Backholer; Alan J Tilbrook
Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but y1-receptor-selective agonist stimulates voluntary food intake.
Endocrinology 2005;146(2):769-75.
2005: Elizabeth T A Rivalland; Javed Iqbal; Iain J Clarke; Anne I Turner; Alan J Tilbrook
Co-localization and distribution of corticotrophin-releasing hormone, arginine vasopressin and enkephalin in the paraventricular nucleus of sheep: a sex comparison.
Neuroscience 2005;132(3):755-66.
2005: Sueli Pompolo; O Ischenko; Alda Pereira; Javed Iqbal; Iain J Clarke
Evidence that projections from the bed nucleus of the stria terminalis and from the lateral and medial regions of the preoptic area provide input to gonadotropin releasing hormone (GNRH) neurons in the female sheep brain.
Neuroscience 2005;132(2):421-36.
2004: Christopher J Scott; Iain J Clarke; A Rao; Alan J Tilbrook
Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe.
Journal of neuroendocrinology 2004;16(12):956-63.
2004: Jillian H Broadbear; Thao Nguyen; Iain J Clarke; Benedict J Canny
Antidepressants, sex steroids and pituitary-adrenal response in sheep.
Psychopharmacology 2004;175(2):247-55.
2004: Kellie M Breen; Catherine A Stackpole; Iain J Clarke; Andrew V Pytiak; Alan J Tilbrook; Elizabeth R Wagenmaker; Elizabeth A Young; Fred J Karsch
Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?
Endocrinology 2004;145(6):2739-46.
2004: BA Henry; JW Goding; Alan J Tilbrook; Frank R Dunshea; Dominique Blache; Iain J Clarke
Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation.
Journal of neuroendocrinology 2004;16(3):244-55.
2004: Jillian H Broadbear; Lisa C Hutton; Iain J Clarke; Benedict J Canny
Sex differences in the pituitary-adrenal response following acute antidepressant treatment in sheep.
Psychopharmacology 2004;171(4):450-7.
2003: Christopher J Scott; Michael Mariani; Iain J Clarke; Alan J Tilbrook
Effect of testosterone and season on proenkephalin messenger RNA expression in the preoptic area of the hypothalamus in the ram.
Biology of reproduction 2003;69(6):2015-21.
2003: KM Estrada; Sueli Pompolo; M J Morris; Alan J Tilbrook; Iain J Clarke
Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: further evidence that NPY has a predominant negative effect on LH secretion in the ewe.
Journal of neuroendocrinology 2003;15(11):1011-20.
2003: Sueli Pompolo; Alda Pereira; Christopher J Scott; Fumino Fujiyma; Iain J Clarke
Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2.
The Journal of comparative neurology 2003;465(1):136-44.
2003: Catherine A Stackpole; Anne I Turner; Iain J Clarke; Gavin Lambert; Alan J Tilbrook
Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes.
Biology of reproduction 2003;69(4):1158-64.
2003: Sueli Pompolo; Alda Pereira; T Kaneko; Iain J Clarke
Seasonal changes in the inputs to gonadotropin-releasing hormone neurones in the ewe brain: an assessment by conventional fluorescence and confocal microscopy.
Journal of neuroendocrinology 2003;15(5):538-45.
2003: Christopher J Scott; Iain J Clarke; Alan J Tilbrook
Neuronal inputs from the hypothalamus and brain stem to the medial preoptic area of the ram: neurochemical correlates and comparison to the ewe.
Biology of reproduction 2003;68(4):1119-33.
2003: Javed Iqbal; BA Henry; Sueli Pompolo; Alexandra Rao; Iain J Clarke
Long-term alteration in bodyweight and food restriction does not affect the gene expression of either preproorexin or prodynorphin in the sheep.
Neuroscience 2003;118(1):217-26.
2003: Iain J Clarke; Alexandra Rao; Yves Chilliard; Carole Delavaud; Gerald A Lincoln
Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(1):R101-15.
2002: Anne I Turner; Elizabeth T A Rivalland; Iain J Clarke; Gavin Lambert; Margaret J Morris; Alan J Tilbrook
Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes.
Neuroendocrinology 2002;76(6):373-80.
2002: Alan J Tilbrook; Anne I Turner; Iain J Clarke
Stress and reproduction: central mechanisms and sex differences in non-rodent species.
Stress (Amsterdam, Netherlands) 2002;5(2):83-100.
2002: Iain J Clarke
Multifarious effects of estrogen on the pituitary gonadotrope with special emphasis on studies in the ovine species.
Archives of physiology and biochemistry 2002;110(1-2):62-73.
2002: Anne I Turner; Benedict J Canny; R J Hobbs; J D Bond; Iain J Clarke; Alan J Tilbrook
Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors.
The Journal of endocrinology 2002;173(1):113-22.
2002: Sueli Pompolo; Christopher J Scott; Iain J Clarke
Selective regulation of glutamic decarboxylase isoform 65, but not isoform 67, in the bed nucleus of the stria terminalis and the preoptic area of the ewe brain across the estrous cycle.
Endocrinology 2002;143(2):544-50.
2002: Iain J Clarke
Two decades of measuring GnRH secretion.
Reproduction (Cambridge, England) Supplement 2002;59():1-13.
2001: Javed Iqbal; Sueli Pompolo; T Sakurai; Iain J Clarke
Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus.
Journal of neuroendocrinology 2001;13(12):1033-41.
2001: Javed Iqbal; Sueli Pompolo; T Murakami; E Grouzmann; T Sakurai; B Meister; Iain J Clarke
Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus.
Brain research 2001;920(1-2):55-64.
2001: BA Henry; Alexandra Rao; B A Ikenasio; Kathleen G Mountjoy; Alan J Tilbrook; Iain J Clarke
Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep.
Brain research 2001;918(1-2):40-50.
2001: Iain J Clarke; Sueli Pompolo; Christopher J Scott; John A Rawson; D Caddy; A E Jakubowska; AM Pereira
Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: a study using Fos immunohistochemistry.
Journal of neuroendocrinology 2001;13(11):934-41.
2001: V A Tobin; Sueli Pompolo; Iain J Clarke
The percentage of pituitary gonadotropes with immunoreactive oestradiol receptors increases in the follicular phase of the ovine oestrous cycle.
Journal of neuroendocrinology 2001;13(10):846-54.
2001: BA Henry; Alexandra Rao; Alan J Tilbrook; Iain J Clarke
Chronic food-restriction alters the expression of somatostatin and growth hormone-releasing hormone in the ovariectomised ewe.
The Journal of endocrinology 2001;170(1):R1-5.
2001: Sueli Pompolo; John A Rawson; Iain J Clarke
Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons.
Brain research 2001;904(1):1-12.
2001: Iain J Clarke; Alan J Tilbrook; Anne I Turner; BW Doughton; JW Goding
Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep.
Endocrinology 2001;142(6):2725-8.
2001: Christopher J Scott; AM Pereira; Alan J Tilbrook; John A Rawson; Iain J Clarke
Changes in preoptic and hypothalamic levels of progesterone receptor mRNA across the oestrous cycle of the ewe.
Journal of neuroendocrinology 2001;13(5):401-6.
2001: Anne I Turner; Alan J Tilbrook; Iain J Clarke; Christopher J Scott
Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH.
The Journal of endocrinology 2001;169(2):291-8.
2001: Alan J Tilbrook; Iain J Clarke
Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males.
Biology of reproduction 2001;64(3):735-42.
2001: John A Rawson; Christopher J Scott; Alda Pereira; A Jakubowska; Iain J Clarke
Noradrenergic projections from the A1 field to the preoptic area in the brain of the ewe and Fos responses to oestrogen in the A1 cells.
Journal of neuroendocrinology 2001;13(2):129-38.
2001: Alan J Tilbrook; David M de Kretser; Iain J Clarke
Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams.
Biology of reproduction 2001;64(2):473-81.
2001: Iain J Clarke
Sex and season are major determinants of voluntary food intake in sheep.
Reproduction, fertility, and development 2001;13(7-8):577-82.
2001: Javed Iqbal; Sueli Pompolo; Laurence M Dumont; Chia-Shan Jenny Wu; Kathleen G Mountjoy; BA Henry; Iain J Clarke
Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and -4 mRNA in the ovine hypothalamus.
Neuroscience 2001;105(4):931-40.
2001: JP Walsh; Alexandra Rao; R C Thompson; Iain J Clarke
Proenkephalin and opioid mu-receptor mRNA expression in ovine hypothalamus across the estrous cycle.
Neuroendocrinology 2001;73(1):26-36.
2001: Iain J Clarke; B Henry; J Iqbal; JW Goding
Leptin and the regulation of food intake and the neuroendocrine axis in sheep.
Clinical and experimental pharmacology & physiology 2001;28(1-2):106-7.
2001: BA Henry; JW Goding; Alan J Tilbrook; Frank R Dunshea; Iain J Clarke
Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight.
The Journal of endocrinology 2001;168(1):67-77.
2000: Javed Iqbal; Sueli Pompolo; T Murakami; Iain J Clarke
Localization of long-form leptin receptor in the somatostatin-containing neurons in the sheep hypothalamus.
Brain research 2000;887(1):1-6.
2000: Iain J Clarke; Christopher J Scott; Alexandra Rao; Sueli Pompolo; M L Barker-Gibb
Seasonal changes in the expression of neuropeptide Y and pro-opiomelanocortin mRNA in the arcuate nucleus of the ovariectomized ewe: relationship to the seasonal appetite and breeding cycles.
Journal of neuroendocrinology 2000;12(11):1105-11.
2000: Chen Chen; Ruwei Xu; Iain J Clarke; M Ruan; K Loneragan; Sang-Gun Roh
Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2+ or K channels in pituitary somatotropes.
Immunology and cell biology 2000;78(4):356-68.
2000: Christopher J Scott; Alan J Tilbrook; Donna M Simmons; John A Rawson; S Chu; P J Fuller; N H Ing; Iain J Clarke
The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females.
Endocrinology 2000;141(8):2951-62.
2000: Christopher J Scott; Alan J Tilbrook; John A Rawson; Iain J Clarke
Gonadal steroid receptors in the regulation of GnRH secretion in farm animals.
Animal reproduction science 2000;60-61():313-26.
2000: M L Barker-Gibb; Iain J Clarke
Effect of season on neuropeptide Y and galanin within the hypothalamus of the ewe in relation to plasma luteinizing hormone concentrations and the breeding season: an immunohistochemical analysis.
Journal of neuroendocrinology 2000;12(7):618-26.
2000: Christopher J Scott; AM Pereira; John A Rawson; Donna M Simmons; W G Rossmanith; N H Ing; Iain J Clarke
The distribution of progesterone receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe: upregulation of progesterone receptor mRNA in the mediobasal hypothalamus by oestrogen.
Journal of neuroendocrinology 2000;12(6):565-75.
2000: Alan J Tilbrook; Anne I Turner; Iain J Clarke
Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences.
Reviews of reproduction 2000;5(2):105-13.
2000: Javed Iqbal; Sueli Pompolo; R V Considine; Iain J Clarke
Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine anterior pituitary.
Endocrinology 2000;141(4):1515-20.
2000: BA Henry; Alan J Tilbrook; Frank R Dunshea; Alexandra Rao; Dominique Blache; Graeme B Martin; Iain J Clarke
Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes.
Endocrinology 2000;141(4):1506-14.
2000: Ruwei Xu; Iain J Clarke; S Chen; Chen Chen
Growth hormone-releasing hormone decreases voltage-gated potassium currents in GH4C1 cells.
Journal of neuroendocrinology 2000;12(2):147-57.
1999: Christopher J Scott; John A Rawson; AM Pereira; Iain J Clarke
Oestrogen receptors in the brainstem of the female sheep: relationship to noradrenergic cells and cells projecting to the medial preoptic area.
Journal of neuroendocrinology 1999;11(10):745-55.
1999: Alan J Tilbrook; Benedict J Canny; B J Stewart; M D Serapiglia; Iain J Clarke
Central administration of corticotrophin releasing hormone but not arginine vasopressin stimulates the secretion of luteinizing hormone in rams in the presence and absence of testosterone.
The Journal of endocrinology 1999;162(2):301-11.
1999: Benedict J Canny; K A O'Farrell; Iain J Clarke; Alan J Tilbrook
The influence of sex and gonadectomy on the hypothalamo-pituitary-adrenal axis of the sheep.
The Journal of endocrinology 1999;162(2):215-25.
1999: Iain J Clarke; Christopher J Scott; Alda Pereira; John A Rawson
Levels of dopamine beta hydroxylase immunoreactivity in the preoptic hypothalamus of the ovariectomised ewe following injection of oestrogen: evidence for increased noradrenaline release around the time of the oestrogen-induced surge in luteinizing hormone.
Journal of neuroendocrinology 1999;11(7):503-12.
1999: Alan J Tilbrook; David M de Kretser; Iain J Clarke
Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin.
The Journal of endocrinology 1999;161(2):219-29.
1999: Michael Alexander cowley; Chen Chen; Iain J Clarke
Estrogen transiently increases delayed rectifier, voltage-dependent potassium currents in ovine gonadotropes.
Neuroendocrinology 1999;69(4):254-60.
1999: Alan J Tilbrook; Benedict J Canny; M D Serapiglia; T J Ambrose; Iain J Clarke
Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids.
The Journal of endocrinology 1999;160(3):469-81.
1999: BA Henry; JW Goding; W S Alexander; Alan J Tilbrook; Benedict J Canny; Frank R Dunshea; Alexandra Rao; A Mansell; Iain J Clarke
Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function.
Endocrinology 1999;140(3):1175-82.
1999: Iain J Clarke; BA Henry
Leptin and reproduction.
Reviews of reproduction 1999;4(1):48-55.
1999: Alan J Tilbrook; David M de Kretser; Iain J Clarke
Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams.
The Journal of endocrinology 1999;160(1):155-67.
1998: S Roh; Iain J Clarke; Ruwei Xu; JW Goding; K Loneragan; Chen Chen
The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland.
Neuroendocrinology 1998;68(6):361-4.
1998: Michael Alexander cowley; A Rao; P J Wright; Nicola Illing; Robert P Millar; Iain J Clarke
Evidence for differential regulation of multiple transcripts of the gonadotropin releasing hormone receptor in the ovine pituitary gland; effect of estrogen.
Molecular and cellular endocrinology 1998;146(1-2):141-9.
1998: JP Walsh; Alexandra Rao; Donna M Simmons; Iain J Clarke
Proopiomelanocortin mRNA levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge.
Journal of neuroendocrinology 1998;10(10):803-8.
1998: Chen Chen; Paul G Farnworth; S Petersenn; IF Musgrave; B J Canny; Iain J Clarke
Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells.
Endocrine 1998;9(1):71-7.
1998: Chen Chen; M Pullar; K Loneragan; J Zhang; Iain J Clarke
Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing hormone (GHRH) on the the cAMP levels and GH release from cultured acromegalic tumours.
Journal of neuroendocrinology 1998;10(6):473-80.
1998: Benedict J Canny; K A O'Farrell; Iain J Clarke; Alan J Tilbrook
Angiotensin II- and phorbol ester-induced steroidogenesis by ovine adrenocortical cells: effect of sex and the gonadal status of the donor animal.
Clinical and experimental pharmacology & physiology 1998;25(6):401-4.
1998: Steven Thomas; M Takahashi; Jimmy Neill; Iain J Clarke
Components of the neuronal exocytotic machinery in the anterior pituitary of the ovariectomised ewe and the effects of oestrogen in gonadotropes as studied with confocal microscopy.
Neuroendocrinology 1998;67(4):244-59.
1998: Iain J Clarke; B W Brown; V V Tran; Christopher J Scott; R Fry; Robert P Millar; Alexandra Rao
Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood.
Endocrinology 1998;139(4):2007-14.
1998: JP Walsh; Iain J Clarke
Blockade of the oestrogen-induced luteinizing hormone surge in ovariectomized ewes by a highly selective opioid mu-receptor agonist: evidence for site of action.
Neuroendocrinology 1998;67(3):164-70.
1998: Christopher J Scott; John A Rawson; AM Pereira; Iain J Clarke
The distribution of estrogen receptors in the brainstem of female sheep.
Neuroscience letters 1998;241(1):29-32.
1997: D Wu; Iain J Clarke; Chen Chen
The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs.
The Journal of endocrinology 1997;154(2):219-30.
1997: Steven Thomas; Iain J Clarke
The positive feedback action of estrogen mobilizes LH-containing, but not FSH-containing secretory granules in ovine gonadotropes.
Endocrinology 1997;138(3):1347-50.
1996: M L Barker-Gibb; Iain J Clarke
Increased galanin and neuropeptide-Y immunoreactivity within the hypothalamus of ovariectomised ewes following a prolonged period of reduced body weight is associated with changes in plasma growth hormone but not gonadotropin levels.
Neuroendocrinology 1996;64(3):194-207.
1996: J P Walsh; Iain J Clarke
Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes.
Endocrinology 1996;137(9):3640-8.
1996: B Thom; Benedict J Canny; Michael Alexander cowley; P J Wright; Iain J Clarke
Changes in the binding characteristics of the mu, delta and kappa subtypes of the opioid receptor in the hypothalamus of the normal cyclic ewe and in the ovariectomised ewe following treatment with ovarian steroids.
The Journal of endocrinology 1996;149(3):509-18.
1996: Terry P Fletcher; G B Thomas; Iain J Clarke
Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6.
Domestic animal endocrinology 1996;13(3):251-8.
1996: Alan J Tilbrook; David M de Kretser; Frank R Dunshea; R Klein; D M Robertson; Iain J Clarke; S Maddocks
The testis is not the major source of circulating follistatin in the ram.
The Journal of endocrinology 1996;149(1):55-63.
1996: Chen Chen; D Wu; Iain J Clarke
Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs.
The Journal of endocrinology 1996;148(3):381-6.
1996: D Wu; Chen Chen; J Zhang; C Y Bowers; Iain J Clarke
The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs.
The Journal of endocrinology 1996;148(2):197-205.
1995: Phil Heyward; Iain J Clarke
A transient effect of estrogen on calcium currents and electrophysiological responses to gonadotropin-releasing hormone in ovine gonadotropes.
Neuroendocrinology 1995;62(6):543-52.
1995: Alan J Tilbrook; Iain J Clarke; David M de Kretser
Human recombinant follistatin-288 suppresses plasma concentrations of follicle-stimulating hormone but is not a significant regulator of luteinizing hormone in castrated rams.
Biology of reproduction 1995;53(6):1353-8.
1995: M L Barker-Gibb; Christopher J Scott; J H Boublik; Iain J Clarke
The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus.
The Journal of endocrinology 1995;147(3):565-79.
1995: Phil Heyward; Chen Chen; Iain J Clarke
Inward membrane currents and electrophysiological responses to GnRH in ovine gonadotropes.
Neuroendocrinology 1995;61(6):609-21.
1995: Iain J Clarke
Evidence that the switch from negative to positive feedback at the level of the pituitary gland is an important timing event for the onset of the preovulatory surge in LH in the ewe.
The Journal of endocrinology 1995;145(2):271-82.
1995: Chen Chen; Iain J Clarke
Effects of growth hormone-releasing peptide-2 (GHRP-2) on membrane Ca2+ permeability in cultured ovine somatotrophs.
Journal of neuroendocrinology 1995;7(3):179-86.
1995: Chen Chen; Iain J Clarke
Modulation of Ca2+ influx in the ovine somatotroph by growth hormone-releasing factor.
The American journal of physiology 1995;268(2 Pt 1):E204-12.
1995: Terry P Fletcher; G B Thomas; Frank R Dunshea; L G Moore; Iain J Clarke
IGF feedback effects on growth hormone secretion in ewes: evidence for action at the pituitary but not the hypothalamic level.
The Journal of endocrinology 1995;144(2):323-31.
1995: Alan J Tilbrook; Iain J Clarke
Negative feedback regulation of the secretion and actions of GnRH in male ruminants.
Journal of reproduction and fertility. Supplement 1995;49():297-306.
1994: Terry P Fletcher; G B Thomas; John O Willoughby; Iain J Clarke
Constitutive growth hormone secretion in sheep after hypothalamopituitary disconnection and the direct in vivo pituitary effect of growth hormone releasing peptide 6.
Neuroendocrinology 1994;60(1):76-86.
1994: J P Liu; Iain J Clarke; J W Funder; D Engler
Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa.
The Journal of clinical investigation 1994;93(4):1439-50.
1994: G B Thomas; Christopher J Scott; J T Cummins; Iain J Clarke
Adrenergic regulation of growth hormone secretion in the ewe.
Domestic animal endocrinology 1994;11(2):187-95.
1994: Terry P Fletcher; Iain J Clarke
Effects of hypothyroidism on the growth hormone axis in sheep.
The Journal of endocrinology 1994;140(3):495-502.
1994: D Wu; Chen Chen; K Katoh; J Zhang; Iain J Clarke
The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist.
The Journal of endocrinology 1994;140(2):R9-13.
1994: Chen Chen; Phil Heyward; J Zhang; D Wu; Iain J Clarke
Voltage-dependent potassium currents in ovine somatotrophs and their function in growth hormone secretion.
Neuroendocrinology 1994;59(1):1-9.
1993: Christopher J Scott; Iain J Clarke
Evidence that changes in the function of the subtypes of the receptors for gamma-amino butyric acid may be involved in the seasonal changes in the negative-feedback effects of estrogen on gonadotropin-releasing hormone secretion and plasma luteinizing hormone levels in the ewe.
Endocrinology 1993;133(6):2904-12.
1993: Phil Heyward; Chen Chen; Iain J Clarke
Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.
Neuroendocrinology 1993;58(6):646-54.
1993: Iain J Clarke; Christopher J Scott
Studies on the neuronal systems involved in the oestrogen-negative feedback effect on gonadotrophin releasing hormone neurons in the ewe.
Human reproduction (Oxford, England) 1993;8 Suppl 2():2-6.
1993: J E Mercer; D J Phillips; Iain J Clarke
Short-term regulation of gonadotropin subunit mRNA levels by estrogen: studies in the hypothalamo-pituitary intact and hypothalamo-pituitary disconnected ewe.
Journal of neuroendocrinology 1993;5(5):591-6.
1993: Iain J Clarke
Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewes.
Endocrinology 1993;133(4):1624-32.
1993: J J Merei; A Rao; Iain J Clarke; I Caroline McMillen
Proopiomelanocortin, prolactin and growth hormone messenger ribonucleic acid levels in the fetal sheep pituitary during late gestation.
Acta endocrinologica 1993;129(3):263-7.
1993: Iain J Clarke; Terry P Fletcher; C C Pomares; J H Holmes; Frank R Dunshea; G B Thomas; Alan J Tilbrook; Paul E Walton; D B Galloway
Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams.
The Journal of endocrinology 1993;138(3):421-7.
1993: Chen Chen; J Zhang; J M Israel; Iain J Clarke; J D Vincent
Mechanism of the prolactin rebound after dopamine withdrawal in rat pituitary cells.
The American journal of physiology 1993;265(1 Pt 1):E145-52.
1993: Christopher J Scott; Iain J Clarke
Inhibition of luteinizing hormone secretion in ovariectomized ewes during the breeding season by gamma-aminobutyric acid (GABA) is mediated by GABA-A receptors, but not GABA-B receptors.
Endocrinology 1993;132(4):1789-96.
1993: Alan J Tilbrook; D B Galloway; A H Williams; Iain J Clarke
Treatment of young rams with an agonist of GnRH delays reproductive development.
Hormones and behavior 1993;27(1):5-28.
1993: Chen Chen; J Zhang; P McNeill; M Pullar; J T Cummins; Iain J Clarke
Human growth hormone releasing factor (hGRF) modulates calcium currents in human growth hormone secreting adenoma cells.
Brain research 1993;604(1-2):345-8.
1993: Iain J Clarke; A Rao; P C Fallest; Margaret A Shupnik
Transcription rate of the follicle stimulating hormone (FSH) beta subunit gene is reduced by inhibin in sheep but this does not fully explain the decrease in mRNA.
Molecular and cellular endocrinology 1993;91(1-2):211-6.
1992: Alan J Tilbrook; David M de Kretser; Iain J Clarke
A role for inhibin in the regulation of the secretion of follicle stimulating hormone in male domestic animals.
Domestic animal endocrinology 1992;9(4):243-60.
1992: Alan J Tilbrook; R J Johnson; P J Eason; J D Walsh; Timothy Trigg; Iain J Clarke
Short-term reduction in egg production in laying hens treated with an agonist of GnRH.
British poultry science 1992;33(3):621-38.
1992: Alan J Tilbrook; Iain J Clarke
Evidence that Dopaminergic Neurons are not Involved in the Negative Feedback Effect of Testosterone on Luteinizing Hormone in Rams in the Non-Breeding Season.
Journal of neuroendocrinology 1992;4(3):365-74.
1992: Christopher J Scott; J T Cumminst; Iain J Clarke
Effects on plasma luteinizing hormone levels of microinjection of noradrenaline and adrenaline into the septo-preoptic area of the brain of the ovariectomized ewe: changes with season and chronic oestrogen treatment.
Journal of neuroendocrinology 1992;4(1):131-41.
1992: Iain J Clarke
What can we learn from sampling hypophysial portal blood?
Ciba Foundation symposium 1992;168():87-95; discussion 95-103.
1991: Alan J Tilbrook; D M de Kretser; J T Cummins; Iain J Clarke
The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram.
Endocrinology 1991;129(6):3080-92.
1991: Alan J Tilbrook; D M de Kretser; Iain J Clarke
Studies on the testicular source of inhibin and its route of secretion in rams: failure of the Leydig cell to secrete inhibin in response to a human chorionic gonadotrophin/LH stimulus.
The Journal of endocrinology 1991;130(1):107-14.
1991: J P Liu; Iain J Clarke; J W Funder; D Engler
Evidence that the central noradrenergic and adrenergic pathways activate the hypothalamic-pituitary-adrenal axis in the sheep.
Endocrinology 1991;129(1):200-9.
1991: G B Thomas; J T Cummins; H Francis; A W Sudbury; P I McCloud; Iain J Clarke
Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes.
Endocrinology 1991;128(2):1151-8.
1991: Iain J Clarke; Alan J Tilbrook; D B Galloway; C R Earl; Jock K Findlay; David M de Kretser
Inhibin in rams.
Journal of reproduction and fertility. Supplement 1991;43():163-70.
1991: Jock K Findlay; Iain J Clarke; M R Luck; Raymond Rodgers; L Shukovski; David M Robertson; R Klein; J F Murray; R J Scaramuzzi; B M Bindon
Peripheral and intragonadal actions of inhibin-related peptides.
Journal of reproduction and fertility. Supplement 1991;43():139-50.
1990: R J Horton; J Y Li; J T Cummins; A I Smith; P J Shen; Iain J Clarke
Morphine decreases LH secretion in ovariectomized ewes only after steroid priming and not by direct pituitary action.
Neuroendocrinology 1990;52(6):612-7.
1990: Iain J Clarke; L M Foulds; S Hayward; J T Cummins; David M Robertson
Analysis of the ratio of biological to immunological LH secreted during the oestrogen-induced LH surge in the ewe.
The Journal of endocrinology 1990;127(2):217-22.
1990: P J Shen; Iain J Clarke; Benedict J Canny; J W Funder; A I Smith
Arginine vasopressin and corticotropin releasing factor: binding to ovine anterior pituitary membranes.
Endocrinology 1990;127(5):2085-9.
1990: D Engler; T Pham; J P Liu; M J Fullerton; Iain J Clarke; J W Funder
Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. II. Evidence for in vivo ultradian hypersecretion of proopiomelanocortin peptides by the isolated anterior and intermediate pituitary.
Endocrinology 1990;127(4):1956-66.
1990: Iain J Clarke; R J Horton; B W Doughton
Investigation of the mechanism by which insulin-induced hypoglycemia decreases luteinizing hormone secretion in ovariectomized ewes.
Endocrinology 1990;127(3):1470-6.
1990: D J Phillips; Iain J Clarke
Effects of the synthetic glucocorticoid dexamethasone on reproductive function in the ewe.
The Journal of endocrinology 1990;126(2):289-95.
1990: G B Thomas; J E Mercer; T Karalis; Alexandra Rao; J T Cummins; Iain J Clarke
Effect of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messenger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariectomized ewes.
Endocrinology 1990;126(3):1361-7.
1990: B J Canny; Iain J Clarke; J W Funder
Adrenocorticotropin responses to endogenous and exogenous secretagogues in the sheep: specificity of glucocorticoid action.
Neuroendocrinology 1990;51(2):181-9.
1990: Jock K Findlay; Iain J Clarke; David M Robertson
Inhibin concentrations in ovarian and jugular venous plasma and the relationship of inhibin with follicle-stimulating hormone and luteinizing hormone during the ovine estrous cycle.
Endocrinology 1990;126(1):528-35.
1989: G B Thomas; J T Cummins; B W Doughton; N Griffin; G A Smythe; R M Gleeson; Iain J Clarke
Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep.
The Journal of endocrinology 1989;123(3):393-402.
1989: B J Canny; J W Funder; Iain J Clarke
Glucocorticoids regulate ovine hypophysial portal levels of corticotropin-releasing factor and arginine vasopressin in a stress-specific manner.
Endocrinology 1989;125(5):2532-9.
1989: G B Thomas; J T Cummins; B J Canny; S E Rundle; N Griffin; S Katsahambas; Iain J Clarke
The posterior pituitary regulates prolactin, but not adrenocorticotropin or gonadotropin, secretion in the sheep.
Endocrinology 1989;125(4):2204-11.
1989: J E Mercer; J A Clements; Iain J Clarke; J W Funder
Glucocorticoid regulation of proopiomelanocortin gene expression in the pituitary gland of hypothalamopituitary intact and hypothalamopituitary disconnected sheep.
Neuroendocrinology 1989;50(3):280-5.
1989: J E Mercer; J A Clements; J W Funder; Iain J Clarke
Regulation of follicle-stimulating hormone beta and common alpha-subunit messenger ribonucleic acid by gonadotropin-releasing hormone and estrogen in the sheep pituitary.
Neuroendocrinology 1989;50(3):321-6.
1989: R J Horton; H Francis; Iain J Clarke
Seasonal and steroid-dependent effects on the modulation of LH secretion in the ewe by intracerebroventricularly administered beta-endorphin or naloxone.
The Journal of endocrinology 1989;122(2):509-17.
1989: Iain J Clarke; J T Cummins; M Jenkin; D J Phillips
The oestrogen-induced surge of LH requires a 'signal' pattern of gonadotrophin-releasing hormone input to the pituitary gland in the ewe.
The Journal of endocrinology 1989;122(1):127-34.
1989: A I Smith; C A Wallace; Iain J Clarke; J W Funder
Dopaminergic agents differentially regulate both processing and content of alpha-N-acetylated endorphin and alpha-MSH in the ovine pituitary intermediate lobe.
Neuroendocrinology 1989;49(5):545-50.
1989: G B Thomas; J T Cummins; G A Smythe; R M Gleeson; R C Dow; George Fink; Iain J Clarke
Concentrations of dopamine and noradrenaline in hypophysial portal blood in the sheep and the rat.
The Journal of endocrinology 1989;121(1):141-7.
1989: D Engler; T Pham; M J Fullerton; G Ooi; J W Funder; Iain J Clarke
Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.
Neuroendocrinology 1989;49(4):367-81.
1989: D Engler; T Pham; M J Fullerton; Iain J Clarke; J W Funder
Evidence for an ultradian secretion of adrenocorticotropin, beta-endorphin and alpha-melanocyte-stimulating hormone by the ovine anterior and intermediate pituitary.
Neuroendocrinology 1989;49(4):349-60.
1989: Iain J Clarke; J T Cummins; M E Crowder; T M Nett
Long-term negative feedback effects of oestrogen and progesterone on the pituitary gland of the long-term ovariectomized ewe.
The Journal of endocrinology 1989;120(2):207-14.
1989: Iain J Clarke
The GNRH/gonadotropin axis in the ewe, cow and sow.
Domestic animal endocrinology 1989;6(1):1-14.
1988: D Engler; T Pham; M J Fullerton; J W Funder; Iain J Clarke
Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.
Neuroendocrinology 1988;48(5):551-60.
1988: R J Horton; Iain J Clarke
Lack of an effect of morphine or naloxone on the oestrogen-induced LH surge in anoestrous ewes.
The Journal of endocrinology 1988;119(1):89-93.
1988: G B Thomas; J T Cummins; B W Doughton; N Griffin; R P Millar; R C Milton; Iain J Clarke
Gonadotropin-releasing hormone associated peptide (GAP) and putative processed GAP peptides do not release luteinizing hormone or follicle-stimulating hormone or inhibit prolactin secretion in the sheep.
Neuroendocrinology 1988;48(4):342-50.
1988: Iain J Clarke; J T Cummins; M E Crowder; T M Nett
Pituitary receptors for gonadotropin-releasing hormone in relation to changes in pituitary and plasma gonadotropins in ovariectomized hypothalamo/pituitary-disconnected ewes. II. A marked rise in receptor number during the acute feedback effects of estradiol.
Biology of reproduction 1988;39(2):349-54.
1988: G B Thomas; J T Cummins; N Griffin; Iain J Clarke
Effect and site of action of hypothalamic neuropeptides on prolactin release in sheep.
Neuroendocrinology 1988;48(3):252-7.
1988: Iain J Clarke
Gonadotrophin-releasing hormone secretion (GnRH) in anoestrous ewes and the induction of GnRH surges by oestrogen.
The Journal of endocrinology 1988;117(3):355-60.
1988: J E Mercer; J A Clements; J W Funder; Iain J Clarke
Luteinizing hormone-beta mRNA levels are regulated primarily by gonadotropin-releasing hormone and not by negative estrogen feedback on the pituitary.
Neuroendocrinology 1988;47(6):563-6.
1988: G B Thomas; J T Cummins; B Yao; K Gordon; Iain J Clarke
Release of prolactin is independent of the secretion of thyrotrophin-releasing hormone into hypophysial portal blood of sheep.
The Journal of endocrinology 1988;117(1):115-22.
1988: G B Thomas; J T Cummins; Iain J Clarke
Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe.
Neuroscience letters 1988;85(1):143-6.
1987: G B Thomas; J T Cummins; Iain J Clarke
Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe.
Neuroscience letters 1987;83(3):323-6.
1987: Iain J Clarke; J T Cummins; M E Crowder; T M Nett
Pituitary receptors for gonadotropin-releasing hormone in relation to changes in pituitary and plasma luteinizing hormone in ovariectomized-hypothalamo pituitary disconnected ewes. I. Effect of changing frequency of gonadotropin-releasing hormone pulses.
Biology of reproduction 1987;37(4):749-54.
1987: J E Mercer; J A Clements; J W Funder; Iain J Clarke
Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin.
Molecular and cellular endocrinology 1987;53(3):251-4.
1987: R J Horton; J T Cummins; Iain J Clarke
Naloxone evokes large-amplitude GnRH pulses in luteal-phase ewes.
Journal of reproduction and fertility 1987;81(1):277-86.
1987: Jock K Findlay; David M Robertson; Iain J Clarke
Influence of dose and route of administration of bovine follicular fluid and the suppressive effect of purified bovine inhibin (Mr 31,000) on plasma FSH concentrations in ovariectomized ewes.
Journal of reproduction and fertility 1987;80(2):455-61.
1987: Iain J Clarke; G B Thomas; B Yao; J T Cummins
GnRH secretion throughout the ovine estrous cycle.
Neuroendocrinology 1987;46(1):82-8.
1987: A I Smith; D Engler; M J Fullerton; T Pham; C Wallace; F J Morgan; Iain J Clarke; J W Funder
Posttranslational processing of corticotropin-releasing factor in the ovine tuberoinfundibular system and pituitary.
Annals of the New York Academy of Sciences 1987;512():24-47.
1986: G B Thomas; J T Cummins; J M Hammond; R J Horton; Iain J Clarke
Prolonged secretion of prolactin in response to thyrotrophin-releasing hormone after hypothalamo-pituitary disconnection in the ewe.
The Journal of endocrinology 1986;111(3):433-8.
1986: Iain J Clarke; K J Burman; B W Doughton; J T Cummins
Effects of constant infusion of gonadotrophin-releasing hormone in ovariectomized ewes with hypothalamo-pituitary disconnection: further evidence for differential control of LH and FSH secretion and the lack of a priming effect.
The Journal of endocrinology 1986;111(1):43-9.
1984: Iain J Clarke; J T Cummins; Jock K Findlay; K J Burman; B W Doughton
Effects on plasma luteinizing hormone and follicle-stimulating hormone of varying the frequency and amplitude of gonadotropin-releasing hormone pulses in ovariectomized ewes with hypothalamo-pituitary disconnection.
Neuroendocrinology 1984;39(3):214-21.