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Stephen Clarke

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Sang-Ryul Lee; Andrew J Monteith; Jose R Roques; Jennifer A Rutan; Stephen H Clarke; Shannon Z Jones; Sun Ah Kang; Michelle A Kilmon; Kristen N Krum; Nikki J Wagner; Barbara J Vilen
Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.
Ye Qian; Stephen H Clarke; Valeria Aoki; Gunter Hans-Filhio; Evandro A Rivitti; Luis A Diaz
Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus.
Trivikram Dasu; Vishal Sindhava; Stephen H Clarke; Subbarao Bondada
CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes.

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2012: Sang-Ryul Lee; Andrew J Monteith; Jose R Roques; Jennifer A Rutan; Stephen H Clarke; Shannon Z Jones; Sun Ah Kang; Michelle A Kilmon; Kristen N Krum; Nikki J Wagner; Barbara J Vilen
Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3859-68.
2009: Ye Qian; Stephen H Clarke; Valeria Aoki; Gunter Hans-Filhio; Evandro A Rivitti; Luis A Diaz
Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus.
The Journal of investigative dermatology 2009;129(12):2823-34.
2009: Trivikram Dasu; Vishal Sindhava; Stephen H Clarke; Subbarao Bondada
CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes.
Molecular immunology 2009;46(13):2655-65.
2008: Ramiro Diz; Suzanne K McCray; Stephen H Clarke
B cell receptor affinity and B cell subset identity integrate to define the effectiveness, affinity threshold, and mechanism of anergy.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):3834-40.
2008: Donna Bunch; Jonathan S Silver; Melanie C Majure; Pamela Sullivan; David A Alcorta; Hyunsook Chin; Susan L Hogan; Yoshi I Lindstrom; Stephen H Clarke; Ronald J Falk; Patrick H Nachman
Maintenance of tolerance by regulation of anti-myeloperoxidase B cells.
Journal of the American Society of Nephrology : JASN 2008;19(9):1763-73.
2008: Matilda W Nicholas; Mary Anne Dooley; Susan L Hogan; Jennifer H Anolik; John Looney; Iñaki Sanz; Stephen H Clarke
A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.
Clinical immunology (Orlando, Fla.) 2008;126(2):189-201.
2008: Stephen H Clarke
Anti-Sm B cell tolerance and tolerance loss in systemic lupus erythematosus.
Immunologic research 2008;41(3):203-16.
2007: Hongsheng Wang; Jianxun Feng; Chen-Feng Qi; Zhaoyang Li; Herbert C Morse; Stephen H Clarke
Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7544-52.
2007: Ye Qian; Luis A Diaz; Jian Ye; Stephen H Clarke
Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5982-90.
2007: Cristina M Contreras; Kristina E Halcomb; Lindsey Randle; Rochelle M Hinman; Toni Gutierrez; Stephen H Clarke; Anne B Satterthwaite
Btk regulates multiple stages in the development and survival of B-1 cells.
Molecular immunology 2007;44(10):2719-28.
2007: Hongsheng Wang; Stephen H Clarke
Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function.
Molecular immunology 2007;44(7):1765-74.
2007: Donna A Culton; Matilda W Nicholas; Donna Bunch; Quan Li Zhen; Thomas B Kepler; Mary Anne Dooley; Chandra Mohan; Patrick H Nachman; Stephen H Clarke
Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.
Journal of clinical immunology 2007;27(1):53-68.
2006: Hongsheng Wang; Matilda W Nicholas; Kara L Conway; Pradip Sen; Ramiro Diz; Roland Tisch; Stephen H Clarke
EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2793-802.
2006: Ye Qian; Kara L Conway; Xiangdong Lu; Heather M Seitz; Glenn K Matsushima; Stephen H Clarke
Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance.
Blood 2006;108(3):974-82.
2006: Donna A Culton; Brian P O'Conner; Kara L Conway; Ramiro Diz; Jennifer A Rutan; Barbara J Vilen; Stephen H Clarke
Early preplasma cells define a tolerance checkpoint for autoreactive B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):790-802.
2005: Michelle A Kilmon; Jennifer A Rutan; Stephen H Clarke; Barbara J Vilen
Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):37-41.
2005: Shannon M Pop; Carmen P Wong; Donna A Culton; Stephen H Clarke; Roland Tisch
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.
The Journal of experimental medicine 2005;201(8):1333-46.
2004: Hongsheng Wang; Stephen H Clarke
Regulation of B-cell development by antibody specificity.
Current opinion in immunology 2004;16(2):246-50.
2004: Hongsheng Wang; Stephen H Clarke
Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function.
Immunological reviews 2004;197():51-9.
2004: Ye Qian; Hongsheng Wang; Stephen H Clarke
Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):625-35.
2003: Hongsheng Wang; Stephen H Clarke
Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6381-8.
2002: Michelle Borrero; Stephen H Clarke
Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):13-21.
2001: GM Fischer; L A Solt; William D Hastings; K Yang; R M Gerstein; Barbara S Nikolajczyk; Stephen H Clarke; Thomas L Rothstein
Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells.
Cellular immunology 2001;213(1):62-71.
2001: Michael Schultz; Stephen H Clarke; LW Arnold; Ryan Sartor; Susan L Tonkonogy
Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice.
Immunology 2001;104(2):127-34.
2001: Hongsheng Wang; J Ye; LW Arnold; S K McCray; Stephen H Clarke
A VH12 transgenic mouse exhibits defects in pre-B cell development and is unable to make IgM+ B cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1254-62.
2001: S Santulli-Marotto; Ye Qian; S Ferguson; Stephen H Clarke
Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5292-9.
2001: Ye Qian; C Santiago; Michelle Borrero; T F Tedder; Stephen H Clarke
Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2412-9.
2000: Hitendra S Jethwa; Stephen H Clarke; Yoshie Itoh-Lindstrom; Ronald J Falk; John Jennette; Patrick H Nachman
Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3890-7.
2000: LW Arnold; S K McCray; C Tatu; Stephen H Clarke
Identification of a precursor to phosphatidyl choline-specific B-1 cells suggesting that B-1 cells differentiate from splenic conventional B cells in vivo: cyclosporin A blocks differentiation to B-1.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2924-30.
2000: C Tatu; Stephen H Clarke
Selective maturation of VH12 B cells in the spleen enriches for anti-phosphatidyl choline B cells: evidence for receptor editing.
Current topics in microbiology and immunology 2000;252():77-86.
2000: Thomas L Rothstein; GM Fischer; Debra Tanguay; S Pavlovic; Thomas P Colarusso; R M Gerstein; Stephen H Clarke; Thomas C Chiles
STAT3 activation, chemokine receptor expression, and cyclin-Cdk function in B-1 cells.
Current topics in microbiology and immunology 2000;252():121-30.
1999: C Tatu; J Ye; LW Arnold; Stephen H Clarke
Selection at multiple checkpoints focuses V(H)12 B cell differentiation toward a single B-1 cell specificity.
The Journal of experimental medicine 1999;190(7):903-14.
1999: S Shinde; Renelle J Gee; S Santulli-Marotto; Linda K Bockenstedt; Stephen H Clarke; Mark J Mamula
T cell autoimmunity in Ig transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7519-24.
1998: Stephen H Clarke; LW Arnold
B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation.
The Journal of experimental medicine 1998;187(8):1325-34.
1998: S Santulli-Marotto; M W Retter; Renelle J Gee; Mark J Mamula; Stephen H Clarke
Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens.
Immunity 1998;8(2):209-19.
1997: MK Wloch; Stephen H Clarke; Gary S Gilkeson
Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6083-90.
1996: Thomas B Kepler; M Borrero; B Rugerio; S K McCray; Stephen H Clarke
Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4451-7.
1996: J Ye; S K McCray; Stephen H Clarke
The transition of pre-BI to pre-BII cells is dependent on the VH structure of the mu/surrogate L chain receptor.
The EMBO journal 1996;15(7):1524-33.
1996: M W Retter; Philip L Cohen; Robert A Eisenberg; Stephen H Clarke
Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1296-306.
1995: J Ye; S K McCray; Stephen H Clarke
The majority of murine VH12-expressing B cells are excluded from the peripheral repertoire in adults.
European journal of immunology 1995;25(9):2511-21.
1995: M W Retter; Robert A Eisenberg; Philip L Cohen; Stephen H Clarke
Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):2248-57.
1995: Gary S Gilkeson; K Bernstein; Anne M Pippen; Stephen H Clarke; T Marion; David S Pisetsky; Phillip Ruiz; J B Lefkowith
The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.
Clinical immunology and immunopathology 1995;76(1 Pt 1):59-67.
1995: R C Rickert; M K Wloch; R L Hahn; Stephen H Clarke
Binding analysis of antibodies produced by precursor and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone. Parallel replacement mutations do not confer increased avidity for hemagglutinin.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2209-16.
1994: D D Bloom; E W St Clair; David S Pisetsky; Stephen H Clarke
The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage.
European journal of immunology 1994;24(6):1332-8.
1994: LW Arnold; C A Pennell; S K McCray; Stephen H Clarke
Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression.
The Journal of experimental medicine 1994;179(5):1585-95.
1993: Stephen H Clarke; S K McCray
VH CDR3-dependent positive selection of murine VH12-expressing B cells in the neonate.
European journal of immunology 1993;23(12):3327-34.
1993: LW Arnold; D H Spencer; Stephen H Clarke; G Haughton
Mechanisms that limit the diversity of antibody: three sequentially acting mechanisms that favor the spontaneous production of germline encoded anti-phosphatidyl choline.
International immunology 1993;5(11):1365-73.
1993: Gary S Gilkeson; D D Bloom; David S Pisetsky; Stephen H Clarke
Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1353-64.
1993: D D Bloom; J L Davignon; M W Retter; Mark J Shlomchik; David S Pisetsky; Philip L Cohen; Robert A Eisenberg; Stephen H Clarke
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1591-610.
1993: D D Bloom; J L Davignon; Philip L Cohen; Robert A Eisenberg; Stephen H Clarke
Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1579-90.
1993: G Haughton; LW Arnold; A C Whitmore; Stephen H Clarke
B-1 cells are made, not born.
Immunology today 1993;14(2):84-7; discussion 87-91.
1990: C A Pennell; E Maynard; LW Arnold; G Haughton; Stephen H Clarke
High frequency expression of S107 VH genes by peritoneal B cells of B10.H-2aH-4bP/WTS mice.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1592-7.
1990: Stephen H Clarke; L M Staudt; J Kavaler; D Schwartz; Walter Gerhard; Martin Weigert
V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2795-801.
1989: C A Pennell; K M Sheehan; Peter H Brodeur; Stephen H Clarke
Organization and expression of VH gene families preferentially expressed by Ly-1+ (CD5) B cells.
European journal of immunology 1989;19(11):2115-21.
1989: C A Pennell; T J Mercolino; T A Grdina; LW Arnold; G Haughton; Stephen H Clarke
Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection.
European journal of immunology 1989;19(7):1289-95.
1988: C A Pennell; LW Arnold; G Haughton; Stephen H Clarke
Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2788-96.
1988: A J Feeney; Stephen H Clarke; Donald E Mosier
Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(4):1267-72.
1985: Stephen H Clarke; K Huppi; D Ruezinsky; L Staudt; Walter Gerhard; Martin Weigert
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.
The Journal of experimental medicine 1985;161(4):687-704.
1984: Stephen H Clarke; S Rudikoff
Evidence for gene conversion among immunoglobulin heavy chain variable region genes.
The Journal of experimental medicine 1984;159(3):773-82.
1984: Stephen H Clarke; James J Kenny; D G Sieckmann; S Rudikoff
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(3):1544-9.
1983: Stephen H Clarke; J L Claflin; M Potter; S Rudikoff
Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.
The Journal of experimental medicine 1983;157(1):98-113.
1982: Stephen H Clarke; J L Claflin; S Rudikoff
Polymorphism in immunoglobulin heavy chains suggesting gene conversion.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(10):3280-4.