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Tim Clausen

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Procedures

X Ray Crystallography

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Escherichia coli

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Publications

TOP 3
Francesca Malvezzi; Karl Mechtler; Alexander Schleiffer; Tim Clausen; Alexander Heuck; Gabriele Litos; Stefan Westermann
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
Linn Gazda; Doris Hellerschmied; Thorsten Hoppe; Thomas Löwe; Felix Mueller-Planitz; Wojciech Pokrzywa; Ignasi Forné; Tim Clausen
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
Martin Breuss; Jamel Chelly; Tim Clausen; Nicholas Justin Cowan; Pierre Gressens; Thomas Gstrein; Matilda Haas; Julian Ik-Tsen Heng; Xavier Hubert Jaglin; Marie-Laure Moutard; Linh Ngo; Sandrine Passemard; Karine Poirier; Zhengdong Qu; Deepa Selvi Rani; Kathryn J H Robson; Kumarasamy Thangaraj; Guoling Tian; Alain Verloes; Yunli Xie; Nadia Bahi-Buisson; Andreas Braun; David A Keays
Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.

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All Publications

2013: Francesca Malvezzi; Karl Mechtler; Alexander Schleiffer; Tim Clausen; Alexander Heuck; Gabriele Litos; Stefan Westermann
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
The EMBO journal 2013;32(3):409-23.
2013: Linn Gazda; Doris Hellerschmied; Thorsten Hoppe; Thomas Löwe; Felix Mueller-Planitz; Wojciech Pokrzywa; Ignasi Forné; Tim Clausen
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
Cell 2013;152(1-2):183-95.
2012: Martin Breuss; Jamel Chelly; Tim Clausen; Nicholas Justin Cowan; Pierre Gressens; Thomas Gstrein; Matilda Haas; Julian Ik-Tsen Heng; Xavier Hubert Jaglin; Marie-Laure Moutard; Linh Ngo; Sandrine Passemard; Karine Poirier; Zhengdong Qu; Deepa Selvi Rani; Kathryn J H Robson; Kumarasamy Thangaraj; Guoling Tian; Alain Verloes; Yunli Xie; Nadia Bahi-Buisson; Andreas Braun; David A Keays
Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Cell reports 2012;2(6):1554-62.
2012: Annette Tennstaedt; Anca Laura Tirniceriu; Linda Truebestein; Alfonso Baldi; Roland Brandt; Anke Brockmann; Tim Clausen; Leif Dehmelt; Rupert Egensperger; Patrick Hauske; Robert Huber; Inga Irle; Markus Kaiser; Hanna Ksiezak-Reding; Christof M Niemeyer; Simon Pöpsel; Barbara Sacca; Nina Schmidt; Michael Ehrmann
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
The Journal of biological chemistry 2012;287(25):20931-41.
2011: Justyna Sawa; Flavia Canellas; Michael Ehrmann; Tobias Krojer; Hélène Malet; Tim Clausen
Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
The Journal of biological chemistry 2011;286(35):30680-90.
2011: Juliane Kley; Bastian Schmidt; Boril Boyanov; Peggy C Stolt-Bergner; Rebecca Kirk; Michael Ehrmann; Ronit R Knopf; Leah Naveh; Zach Adam; Tim Clausen
Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure.
Nature structural & molecular biology 2011;18(6):728-31.
2011: Tim Clausen; Markus Kaiser; Robert Huber; Michael Ehrmann
HTRA proteases: regulated proteolysis in protein quality control.
Nature reviews. Molecular cell biology 2011;12(3):152-62.
2011: Linda Truebestein; Annette Tennstaedt; Timon Mönig; Tobias Krojer; Flavia Canellas; Markus Kaiser; Tim Clausen; Michael Ehrmann
Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nature structural & molecular biology 2011;18(3):386-8.
2011: Melisa Merdanovic; Tim Clausen; Robert Huber; Markus Kaiser; Michael Ehrmann
Protein quality control in the bacterial periplasm.
Annual review of microbiology 2011;65():149-68.
2010: Tobias Krojer; Justyna Sawa; Robert Huber; Tim Clausen
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.
Nature structural & molecular biology 2010;17(7):844-52.
2010: Sonja Hasenbein; Michael Meltzer; Patrick Hauske; Markus Kaiser; Robert Huber; Tim Clausen; Michael Ehrmann
Conversion of a regulatory into a degradative protease.
Journal of molecular biology 2010;397(4):957-66.
2010: Justyna Sawa; Alexander Heuck; Michael Ehrmann; Tim Clausen
Molecular transformers in the cell: lessons learned from the DegP protease-chaperone.
Current opinion in structural biology 2010;20(2):253-8.
2009: Michael Meltzer; Sonja Hasenbein; Nicolette Mamant; Melisa Merdanovic; Simon Poepsel; Patrick Hauske; Markus Kaiser; Robert Huber; Tobias Krojer; Tim Clausen; Michael Ehrmann
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Research in microbiology 2009;160(9):660-6.
2009: Constanze Breithaupt; Robert Kurzbauer; Florian Schaller; Annick Stintzi; Andreas Schaller; Robert Huber; Peter Macheroux; Tim Clausen
Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.
Journal of molecular biology 2009;392(5):1266-77.
2009: Patrick Hauske; Nicolette Mamant; Sonja Hasenbein; Sabrina Nickel; Christian Ottmann; Tim Clausen; Michael Ehrmann; Markus Kaiser
Peptidic small molecule activators of the stress sensor DegS.
Molecular bioSystems 2009;5(9):980-5.
2009: Jakob Fuhrmann; Andreas Schmidt; Silvia Spiess; Anita Lehner; Kürsad Turgay; Karl Mechtler; Emmanuelle Charpentier; Tim Clausen
McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR.
Science (New York, N.Y.) 2009;324(5932):1323-7.
2009: Patrick Hauske; Michael Meltzer; Christian Ottmann; Tobias Krojer; Tim Clausen; Michael Ehrmann; Markus Kaiser
Selectivity profiling of DegP substrates and inhibitors.
Bioorganic & medicinal chemistry 2009;17(7):2920-4.
2008: Tobias Krojer; Justyna Sawa; Eva Schäfer; Helen R Saibil; Michael Ehrmann; Tim Clausen
Structural basis for the regulated protease and chaperone function of DegP.
Nature 2008;453(7197):885-90.
2008: Tobias Krojer; Karen Pangerl; Juliane Kurt; Justyna Sawa; Christoph Stingl; Karl Mechtler; Robert Huber; Michael Ehrmann; Tim Clausen
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7702-7.
2008: Michael Meltzer; Sonja Hasenbein; Patrick Hauske; Nicolette Kucz; Melisa Merdanovic; Sandra Grau; Alexandra Beil; Dafydd Jones; Tobias Krojer; Tim Clausen; Michael Ehrmann; Markus Kaiser
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.
Angewandte Chemie (International ed. in English) 2008;47(7):1332-4.
2007: Hanna Hasselblatt; Robert Kurzbauer; Corinna Wilken; Tobias Krojer; Justyna Sawa; Juliane Kurt; Rebecca Kirk; Sonja Hasenbein; Michael Ehrmann; Tim Clausen
Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.
Genes & development 2007;21(20):2659-70.
2006: Constanze Breithaupt; Robert Kurzbauer; Hauke Lilie; Andreas Schaller; Jochen Strassner; Robert Huber; Peter Macheroux; Tim Clausen
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14337-42.
2005: Karina Kitzing; Teresa B Fitzpatrick; Corinna Wilken; Justyna Sawa; Gleb P Bourenkov; Peter Macheroux; Tim Clausen
The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes.
The Journal of biological chemistry 2005;280(30):27904-13.
2004: Teresa B Fitzpatrick; Sigrid Auweter; Karina Kitzing; Tim Clausen; Nikolaus Amrhein; Peter Macheroux
Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation.
Protein expression and purification 2004;36(2):280-91.
2004: Robert Kurzbauer; David Teis; Mariana E G de Araujo; Sebastian Maurer-Stroh; Frank Eisenhaber; Gleb P Bourenkov; Hans D Bartunik; Mirko Hekman; Ulf R Rapp; Lukas A Huber; Tim Clausen
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):10984-9.
2004: Corinna Wilken; Karina Kitzing; Robert Kurzbauer; Michael Ehrmann; Tim Clausen
Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.
Cell 2004;117(4):483-94.
2003: Albrecht Messerschmidt; Michael Worbs; Clemens Steegborn; Markus C Wahl; Robert Huber; Bernd Laber; Tim Clausen
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.
Biological chemistry 2003;384(3):373-86.
2003: Jens Thomas Kaiser; Stefano Bruno; Tim Clausen; Robert Huber; Francesca Schiaretti; Andrea Mozzarelli; Dorothea Kessler
Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state.
The Journal of biological chemistry 2003;278(1):357-65.
2002: Tim Clausen; Chris Southan; Michael Ehrmann
The HtrA family of proteases: implications for protein composition and cell fate.
Molecular cell 2002;10(3):443-55.
2002: Marta Garrido-Franco; Bernd Laber; Robert Huber; Tim Clausen
Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.
Journal of molecular biology 2002;321(4):601-12.
2002: Marta Garrido-Franco; Stephan Ehlert; Albrecht Messerschmidt; Snezan Marinkovic'; Robert Huber; Bernd Laber; Gleb P Bourenkov; Tim Clausen
Structure and function of threonine synthase from yeast.
The Journal of biological chemistry 2002;277(14):12396-405.
2002: Tobias Krojer; Marta Garrido-Franco; Robert Huber; Michael Ehrmann; Tim Clausen
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
Nature 2002;416(6879):455-9.
2001: Clemens Steegborn; O Danot; Robert Huber; Tim Clausen
Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization.
Structure (London, England : 1993) 2001;9(11):1051-60.
2001: Clemens Steegborn; Bernd Laber; Albrecht Messerschmidt; Robert Huber; Tim Clausen
Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
Journal of molecular biology 2001;311(4):789-801.
2001: U Breitinger; Tim Clausen; Stephan Ehlert; Robert Huber; Bernd Laber; F Schmidt; E Pohl; Albrecht Messerschmidt
The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity.
Plant physiology 2001;126(2):631-42.
2001: Constanze Breithaupt; Jochen Strassner; U Breitinger; Robert Huber; Peter Macheroux; Andreas Schaller; Tim Clausen
X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE.
Structure (London, England : 1993) 2001;9(5):419-29.
2001: M G Franco; Bernd Laber; Robert Huber; Tim Clausen
Structural basis for the function of pyridoxine 5'-phosphate synthase.
Structure (London, England : 1993) 2001;9(3):245-53.
2000: Marta Garrido-Franco; Robert Huber; F S Schmidt; Bernd Laber; Tim Clausen
Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1045-8.
2000: H I Krupka; Robert Huber; S C Holt; Tim Clausen
Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme.
The EMBO journal 2000;19(13):3168-78.
2000: Tim Clausen; Johannes Kaiser; Clemens Steegborn; Robert Huber; Dorothea Kessler
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3856-61.
2000: Johannes Kaiser; Tim Clausen; Gleb Bourenkow; Hans D Bartunik; Stefan Steinbacher; Robert Huber
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly.
Journal of molecular biology 2000;297(2):451-64.
2000: Tim Clausen; Anja Schlegel; Ralf Peist; E Schneider; Clemens Steegborn; Y S Chang; A Haase; Gleb P Bourenkov; Hans D Bartunik; Winfried Boos
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.
The EMBO journal 2000;19(5):831-42.
2000: Valérie Schreiber; Clemens Steegborn; Tim Clausen; Winfried Boos; Evelyne Richet
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.
Molecular microbiology 2000;35(4):765-76.
1999: Tim Clausen; Markus C Wahl; Albrecht Messerschmidt; Robert Huber; J C Fuhrmann; Bernd Laber; W Streber; Clemens Steegborn
Cloning, purification and characterisation of cystathionine gamma-synthase from Nicotiana tabacum.
Biological chemistry 1999;380(10):1237-42.
1999: Clemens Steegborn; Albrecht Messerschmidt; Bernd Laber; W Streber; Robert Huber; Tim Clausen
The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
Journal of molecular biology 1999;290(5):983-96.
1999: Bernd Laber; W Maurer; C Hanke; Susanna Gräfe; Stephan Ehlert; Albrecht Messerschmidt; Tim Clausen
Characterization of recombinant Arabidopsis thaliana threonine synthase.
European journal of biochemistry / FEBS 1999;263(1):212-21.
1999: Clemens Steegborn; Tim Clausen; Peter Sondermann; Uwe Jacob; Michael Worbs; S Marinkovic; Robert Huber; Markus C Wahl
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.
The Journal of biological chemistry 1999;274(18):12675-84.
1998: Tim Clausen; Robert Huber; L Prade; Markus C Wahl; Albrecht Messerschmidt
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.
The EMBO journal 1998;17(23):6827-38.
1997: Tim Clausen; Robert Huber; Albrecht Messerschmidt; H D Pohlenz; Bernd Laber
Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study.
Biochemistry 1997;36(41):12633-43.
1997: Markus C Wahl; Robert Huber; L Prade; S Marinkovic; Albrecht Messerschmidt; Tim Clausen
Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.
FEBS letters 1997;414(3):492-6.
1997: Uwe Jacob; M Mack; Tim Clausen; Robert Huber; Wolfgang Buckel; Albrecht Messerschmidt
Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases.
Structure (London, England : 1993) 1997;5(3):415-26.
1997: Tim Clausen; Bernd Laber; Albrecht Messerschmidt
Mode of action of cystathionine beta-lyase.
Biological chemistry 1997;378(3-4):321-6.
1996: Tim Clausen; Robert Huber; Bernd Laber; H D Pohlenz; Albrecht Messerschmidt
Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A.
Journal of molecular biology 1996;262(2):202-24.
1996: Bernd Laber; Tim Clausen; Robert Huber; Albrecht Messerschmidt; U Egner; A Müller-Fahrnow; H D Pohlenz
Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase.
FEBS letters 1996;379(1):94-6.