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Valerie Clerin

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TOP 3
Lacramioara Ivanciu; Haein Kim; Jian-Hua Liu; Paris Margaritis; Giulia Pavani; Debra D Pittman; Rosalind Rose-Miranda; Alexander Schlachterman; Kathleen M Shields; James F Tobin; Raffaella Toso; Valder R Arruda; Valerie Clerin; David V Erbe; Rodney M Camire
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.
Adrian Huang; Alessandro Moretto; Kristin Janz; Michael Lowe; Patricia W Bedard; Steve Tam; Li Di; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Desiree H H Tsao; James Carl Keith; Gray D Shaw; Robert G Schaub; Qin Wang; Neelu Kaila
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Elaine Quinet; Michael D Basso; Anita R Halpern; David W Yates; Robert J Steffan; Valerie Clerin; Christine Resmini; James C Keith; Thomas J Berrodin; Irene Feingold; Wenyan Zhong; Helen B Hartman; Mark J Evans; Stephen J Gardell; Elizabeth DiBlasio-Smith; William M Mounts; Edward R LaVallie; Jay Wrobel; Ponnal Nambi; George P Vlasuk
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.

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All Publications

2011: Lacramioara Ivanciu; Haein Kim; Jian-Hua Liu; Paris Margaritis; Giulia Pavani; Debra D Pittman; Rosalind Rose-Miranda; Alexander Schlachterman; Kathleen M Shields; James F Tobin; Raffaella Toso; Valder R Arruda; Valerie Clerin; David V Erbe; Rodney M Camire
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.
Nature biotechnology 2011;29(11):1028-33.
2010: Adrian Huang; Alessandro Moretto; Kristin Janz; Michael Lowe; Patricia W Bedard; Steve Tam; Li Di; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Desiree H H Tsao; James Carl Keith; Gray D Shaw; Robert G Schaub; Qin Wang; Neelu Kaila
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Journal of medicinal chemistry 2010;53(16):6003-17.
2009: Elaine Quinet; Michael D Basso; Anita R Halpern; David W Yates; Robert J Steffan; Valerie Clerin; Christine Resmini; James C Keith; Thomas J Berrodin; Irene Feingold; Wenyan Zhong; Helen B Hartman; Mark J Evans; Stephen J Gardell; Elizabeth DiBlasio-Smith; William M Mounts; Edward R LaVallie; Jay Wrobel; Ponnal Nambi; George P Vlasuk
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.
Journal of lipid research 2009;50(12):2358-70.
2008: Patricia W Bedard; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Thomas Antrilli; Christine Resmini; James Carl Keith; James K Hennan; Neelu Kaila; Silvano DeBernardo; Kristin Janz; Qin Wang; David L Crandall; Robert G Schaub; Gray D Shaw; Laura L Carter
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
The Journal of pharmacology and experimental therapeutics 2008;324(2):497-506.
2007: Baihua Hu; James Jetter; David Kaufman; Robert Singhaus; Ronald C Bernotas; Rayomand J Unwalla; Elaine Quinet; Dawn A Savio; Anita Halpern; Michael Basso; James Carl Keith; Valerie Clerin; Liang Chen; Qiang-Yuan Liu; Irene Feingold; Christine Huselton; Farooq Azam; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Jay Wrobel
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.
Bioorganic & medicinal chemistry 2007;15(10):3321-33.
2007: Neelu Kaila; Kristin Janz; Adrian Huang; Alessandro Moretto; Silvano DeBernardo; Patricia W Bedard; Steve Tam; Valerie Clerin; James Carl Keith; Desirée H H Tsao; Natalia Sushkova; Gray D Shaw; Raymond T Camphausen; Robert G Schaub; Qin Wang
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Journal of medicinal chemistry 2007;50(1):40-64.
2006: Baihua Hu; Michael Collini; Rayomand J Unwalla; Christopher Miller; Robert Singhaus; Elaine Quinet; Dawn A Savio; Anita Halpern; Michael Basso; James Carl Keith; Valerie Clerin; Liang Chen; Christine Resmini; Qiang-Yuan Liu; Irene Feingold; Christine Huselton; Farooq Azam; Mathias Farnegardh; Cristofer Enroth; Tomas Bonn; Annika Goos-Nilsson; Anna Wilhelmsson; Ponnal Nambi; Jay Wrobel
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Journal of medicinal chemistry 2006;49(21):6151-4.
2003: Valerie Clerin; Jason W Nichol; Matus Petko; Richard J Myung; J William Gaynor; Keith J Gooch
Tissue engineering of arteries by directed remodeling of intact arterial segments.
Tissue engineering 2003;9(3):461-72.
2002: Valerie Clerin; Rebecca J Gusic; J O'Brien; Paul M Kirshbom; Richard J Myung; J William Gaynor; Keith J Gooch
Mechanical environment, donor age, and presence of endothelium interact to modulate porcine artery viability ex vivo.
Annals of biomedical engineering 2002;30(9):1117-27.