Hans Clevers

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Mahmoudi Tokameh; Li Vivian S W; Ng Ser Sue; Taouatas Nadia; Vries Robert G J; Mohammed Shabaz; Heck Albert J; Clevers Hans
The kinase TNIK is an essential activator of Wnt target genes.
Clevers Hans
Eyeing up new Wnt pathway players.
Chen Gang; Korfhagen Thomas R; Xu Yan; Kitzmiller Joseph; Wert Susan E; Maeda Yutaka; Gregorieff Alexander; Clevers Hans; Whitsett Jeffrey A
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

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All Publications

2009: Mahmoudi Tokameh; Li Vivian S W; Ng Ser Sue; Taouatas Nadia; Vries Robert G J; Mohammed Shabaz; Heck Albert J; Clevers Hans
The kinase TNIK is an essential activator of Wnt target genes.
The EMBO journal 2009;28(21):3329-40.
2009: Clevers Hans
Eyeing up new Wnt pathway players.
Cell 2009;139(2):227-9.
2009: Chen Gang; Korfhagen Thomas R; Xu Yan; Kitzmiller Joseph; Wert Susan E; Maeda Yutaka; Gregorieff Alexander; Clevers Hans; Whitsett Jeffrey A
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
The Journal of clinical investigation 2009;119(10):2914-24.
2009: Begus-Nahrmann Yvonne; Lechel André; Obenauf Anna C; Nalapareddy Kodandaramireddy; Peit Elvira; Hoffmann Eva; Schlaudraff Falk; Liss Birgit; Schirmacher Peter; Kestler Hans; Danenberg Esther; Barker Nick; Clevers Hans; Speicher Michael R; Rudolph K Lenhard
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
Nature genetics 2009;41(10):1138-43.
2009: Gregorieff Alex; Stange Daniel E; Kujala Pekka; Begthel Harry; van den Born Maaike; Korving Jeroen; Peters Peter J; Clevers Hans
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gastroenterology 2009;137(4):1333-45.e1-3.
2009: Fu Hui; Cai Jun; Clevers Hans; Fast Eva; Gray Susan; Greenberg Rachel; Jain Mukesh K; Ma Qiufu; Qiu Mengsheng; Rowitch David H; Taylor Christopher M; Stiles Charles D
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11399-408.
2009: Jansen Marnix; Ten Klooster Jean Paul; Offerhaus G Johan; Clevers Hans
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
Physiological reviews 2009;89(3):777-98.
2009: Ye Feng; Chen Ying; Hoang ThaoNguyen; Montgomery Rusty L; Zhao Xian-hui; Bu Hong; Hu Tom; Taketo Makoto M; van Es Johan H; Clevers Hans; Hsieh Jenny; Bassel-Duby Rhonda; Olson Eric N; Lu Q Richard
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Nature neuroscience 2009;12(7):829-38.
2009: van der Flier Laurens G; Haegebarth Andrea; Stange Daniel E; van de Wetering Marc; Clevers Hans
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
Gastroenterology 2009;137(1):15-7.
2009: Snippert Hugo J; van Es Johan H; van den Born Maaike; Begthel Harry; Stange Daniel E; Barker Nick; Clevers Hans
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Gastroenterology 2009;136(7):2187-2194.e1.
2009: Sato Toshiro; Vries Robert G; Snippert Hugo J; van de Wetering Marc; Barker Nick; Stange Daniel E; van Es Johan H; Abo Arie; Kujala Pekka; Peters Peter J; Clevers Hans
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature 2009;459(7244):262-5.
2009: ten Klooster Jean Paul; Jansen Marnix; Yuan Jin; Oorschot Viola; Begthel Harry; Di Giacomo Valeria; Colland Frédéric; de Koning John; Maurice Madelon M; Hornbeck Peter; Clevers Hans
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
Developmental cell 2009;16(4):551-62.
2009: Faro Ana; Boj Sylvia F; Ambrósio Raquel; van den Broek Olaf; Korving Jeroen; Clevers Hans
T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.
Zebrafish 2009;6(1):59-68.
2009: van der Flier Laurens G; van Gijn Marielle E; Hatzis Pantelis; Kujala Pekka; Haegebarth Andrea; Stange Daniel E; Begthel Harry; van den Born Maaike; Guryev Victor; Oving Irma; van Es Johan H; Barker Nick; Peters Peter J; van de Wetering Marc; Clevers Hans
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell 2009;136(5):903-12.
2009: Haegebarth Andrea; Clevers Hans
Wnt signaling, lgr5, and stem cells in the intestine and skin.
The American journal of pathology 2009;174(3):715-21.
2009: Clevers Hans
Inflammatory bowel disease, stress, and the endoplasmic reticulum.
The New England journal of medicine 2009;360(7):726-7.
2009: Barker Nick; Ridgway Rachel A; van Es Johan H; van de Wetering Marc; Begthel Harry; van den Born Maaike; Danenberg Esther; Clarke Alan R; Sansom Owen J; Clevers Hans
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2009: van der Flier Laurens G; Clevers Hans
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
Annual review of physiology 2009;71():241-60.
2008: Offerhaus G J A; Milne A N A; Oving I M; van Gijn M E; Hruban R H; Clevers H
A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling.
Gut 2008;57(12):1739-40.
2008: Jaks Viljar; Barker Nick; Kasper Maria; van Es Johan H; Snippert Hugo J; Clevers Hans; Toftgård Rune
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Nature genetics 2008;40(11):1291-9.
2008: Goessling Wolfram; North Trista E; Lord Allegra M; Ceol Craig; Lee Sang; Weidinger Gilbert; Bourque Caitlin; Strijbosch Robbert; Haramis Anna-Pavlina; Puder Mark; Clevers Hans; Moon Randall T; Zon Leonard I
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.
Developmental biology 2008;320(1):161-74.
2008: Barker Nick; van de Wetering Marc; Clevers Hans
The intestinal stem cell.
Genes & development 2008;22(14):1856-64.
2008: Burns Carole J; Zhang Jianmin; Brown Erinn C; Van Bibber Alyssa M; Van Es Johan; Clevers Hans; Ishikawa Tomo-o; Taketo M Mark; Vetter Monica L; Fuhrmann Sabine
Investigation of Frizzled-5 during embryonic neural development in mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(6):1614-26.
2008: Riccio Orbicia; van Gijn Marielle E; Bezdek April C; Pellegrinet Luca; van Es Johan H; Zimber-Strobl Ursula; Strobl Lothar J; Honjo Tasuku; Clevers Hans; Radtke Freddy
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
EMBO reports 2008;9(4):377-83.
2008: Hatzis Pantelis; van der Flier Laurens G; van Driel Marc A; Guryev Victor; Nielsen Fiona; Denissov Sergei; Nijman Isaäc J; Koster Jan; Santo Evan E; Welboren Willem; Versteeg Rogier; Cuppen Edwin; van de Wetering Marc; Clevers Hans; Stunnenberg Hendrik G
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
Molecular and cellular biology 2008;28(8):2732-44.
2008: Barker N; van Es J H; Jaks V; Kasper M; Snippert H; Toftgård R; Clevers H
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():351-6.
2007: Sabates-Bellver Jacob; Van der Flier Laurens G; de Palo Mariagrazia; Cattaneo Elisa; Maake Caroline; Rehrauer Hubert; Laczko Endre; Kurowski Michal A; Bujnicki Janusz M; Menigatti Mirco; Luz Judith; Ranalli Teresa V; Gomes Vito; Pastorelli Alfredo; Faggiani Roberto; Anti Marcello; Jiricny Josef; Clevers Hans; Marra Giancarlo
Transcriptome profile of human colorectal adenomas.
Molecular cancer research : MCR 2007;5(12):1263-75.
2007: Barker Nick; Clevers Hans
Tracking down the stem cells of the intestine: strategies to identify adult stem cells.
Gastroenterology 2007;133(6):1755-60.
2007: Kessler Benedikt M; Fortunati Elisabetta; Melis Monique; Pals Cornelieke E G M; Clevers Hans; Maurice Madelon M
Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.
Journal of proteome research 2007;6(11):4163-72.
2007: Barker Nick; van Es Johan H; Kuipers Jeroen; Kujala Pekka; van den Born Maaike; Cozijnsen Miranda; Haegebarth Andrea; Korving Jeroen; Begthel Harry; Peters Peter J; Clevers Hans
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Nature 2007;449(7165):1003-7.
2007: van Noort Mascha; Weerkamp Floor; Clevers Hans C; Staal Frank J T
Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools.
Blood 2007;110(7):2778-9.
2007: Muncan Vanesa; Faro Ana; Haramis Anna-Pavlina G; Hurlstone Adam F L; Wienholds Erno; van Es Johan; Korving Jeroen; Begthel Harry; Zivkovic Danica; Clevers Hans
T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.
EMBO reports 2007;8(10):966-73.
2007: Gregorieff Alex; Clevers Hans
Giving APCmin tumours a SPARC.
Gut 2007;56(10):1341-3.
2007: Wehkamp Jan; Wang Guoxing; Kübler Irmgard; Nuding Sabine; Gregorieff Alex; Schnabel Anke; Kays Robert J; Fellermann Klaus; Burk Oliver; Schwab Matthias; Clevers Hans; Bevins Charles L; Stange Eduard F
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3109-18.
2007: Brugmann Samantha A; Goodnough L Henry; Gregorieff Alex; Leucht Philipp; ten Berge Derk; Fuerer Christophe; Clevers Hans; Nusse Roel; Helms Jill A
Wnt signaling mediates regional specification in the vertebrate face.
Development (Cambridge, England) 2007;134(18):3283-95.
2007: Mori-Akiyama Yuko; van den Born Maaike; van Es Johan H; Hamilton Stanley R; Adams Henry P; Zhang Jiexin; Clevers Hans; de Crombrugghe Benoit
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.
Gastroenterology 2007;133(2):539-46.
2007: Kojima Yasushi; Miyoshi Hiroyuki; Clevers Hans C; Oshima Masanobu; Aoki Masahiro; Taketo Makoto M
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
The Journal of biological chemistry 2007;282(32):23532-40.
2007: Sansom Owen J; Meniel Valerie S; Muncan Vanesa; Phesse Toby J; Wilkins Julie A; Reed Karen R; Vass J Keith; Athineos Dimitris; Clevers Hans; Clarke Alan R
Myc deletion rescues Apc deficiency in the small intestine.
Nature 2007;446(7136):676-9.
2007: Malaterre Jordane; Carpinelli Marina; Ernst Matthias; Alexander Warren; Cooke Michael; Sutton Susan; Dworkin Sebastian; Heath Joan K; Frampton Jon; McArthur Grant; Clevers Hans; Hilton Douglas; Mantamadiotis Theo; Ramsay Robert G
c-Myb is required for progenitor cell homeostasis in colonic crypts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3829-34.
2007: Van der Flier Laurens G; Sabates-Bellver Jacob; Oving Irma; Haegebarth Andrea; De Palo Mariagrazia; Anti Marcello; Van Gijn Marielle E; Suijkerbuijk Saskia; Van de Wetering Marc; Marra Giancarlo; Clevers Hans
The Intestinal Wnt/TCF Signature.
Gastroenterology 2007;132(2):628-32.
2007: Vooijs Marc; Ong Chin-Tong; Hadland Brandon; Huppert Stacey; Liu Zhenyi; Korving Jeroen; van den Born Maaike; Stappenbeck Thaddeus; Wu Yumei; Clevers Hans; Kopan Raphael
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
Development (Cambridge, England) 2007;134(3):535-44.
2007: de Lau Wim; Barker Nick; Clevers Hans
WNT signaling in the normal intestine and colorectal cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():471-91.
2006: Barker Nick; Clevers Hans
Mining the Wnt pathway for cancer therapeutics.
Nature reviews. Drug discovery 2006;5(12):997-1014.
2006: Clevers Hans
Wnt/beta-catenin signaling in development and disease.
Cell 2006;127(3):469-80.
2006: Muncan Vanesa; Sansom Owen J; Tertoolen Leon; Phesse Toby J; Begthel Harry; Sancho Elena; Cole Alicia M; Gregorieff Alex; de Alboran Ignacio Moreno; Clevers Hans; Clarke Alan R
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Molecular and cellular biology 2006;26(22):8418-26.
2006: Markiewicz Ewa; Tilgner Katarzyna; Barker Nick; van de Wetering Mark; Clevers Hans; Dorobek Margareth; Hausmanowa-Petrusewicz Irena; Ramaekers Frans C S; Broers Jos L V; Blankesteijn W Matthijs; Salpingidou Georgia; Wilson Robert G; Ellis Juliet A; Hutchison Christopher J
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
The EMBO journal 2006;25(14):3275-85.
2006: Thiele Andrea; Nagamine Yoshikuni; Hauschildt Sunna; Clevers Hans
AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability.
Experimental cell research 2006;312(12):2367-78.
2006: Radtke Freddy; Clevers Hans; Riccio Orbicia
From gut homeostasis to cancer.
Current molecular medicine 2006;6(3):275-89.
2006: Giles R H; Lolkema M P; Snijckers C M; Belderbos M; van der Groep P; Mans D A; van Beest M; van Noort M; Goldschmeding R; van Diest P J; Clevers H; Voest E E
Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis.
Oncogene 2006;25(21):3065-70.
2006: Huang Zhaofeng; Xie Huimin; Ioannidis Vassilio; Held Werner; Clevers Hans; Sadim Maureen S; Sun Zuoming
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4880-7.
2006: Haramis Anna-Pavlina G; Hurlstone Adam; van der Velden Yme; Begthel Harry; van den Born Maaike; Offerhaus G Johan A; Clevers Hans C
Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.
EMBO reports 2006;7(4):444-9.
2006: Clevers Hans
Colon cancer--understanding how NSAIDs work.
The New England journal of medicine 2006;354(7):761-3.
2006: Holstege Frank C P; Clevers Hans
Transcription factor target practice.
Cell 2006;124(1):21-3.
2006: Clevers Hans; Batlle Eduard
EphB/EphrinB receptors and Wnt signaling in colorectal cancer.
Cancer research 2006;66(1):2-5.
2006: Malliri Angeliki; Rygiel Tomasz P; van der Kammen Rob A; Song Ji-Ying; Engers Rainer; Hurlstone Adam F L; Clevers Hans; Collard John G
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
The Journal of biological chemistry 2006;281(1):543-8.
2005: Wilson Maria E; Yang Katherine Y; Kalousova Anna; Lau Janet; Kosaka Yasuhiro; Lynn Francis C; Wang Juehu; Mrejen Caroline; Episkopou Vasso; Clevers Hans C; German Michael S
The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
Diabetes 2005;54(12):3402-9.
2005: van Es Johan H; Clevers Hans
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.
Trends in molecular medicine 2005;11(11):496-502.
2005: Clevers Hans
Stem cells, asymmetric division and cancer.
Nature genetics 2005;37(10):1027-8.
2005: Gregorieff Alex; Pinto Daniel; Begthel Harry; Destrée Olivier; Kielman Menno; Clevers Hans
Expression pattern of Wnt signaling components in the adult intestine.
Gastroenterology 2005;129(2):626-38.
2005: Sansom Owen J; Reed Karen R; van de Wetering Marc; Muncan Vanesa; Winton Douglas J; Clevers Hans; Clarke Alan R
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.
The Journal of biological chemistry 2005;280(31):28463-7.
2005: Riedl Jurgen A; Brandt Dominique T; Batlle Eduard; Price Leo S; Clevers Hans; Bos Johannes L
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.
The Biochemical journal 2005;389(Pt 2):465-9.
2005: Batlle Eduard; Bacani Julinor; Begthel Harry; Jonkheer Suzanne; Gregorieff Alexander; van de Born Maaike; Malats Núria; Sancho Elena; Boon Elles; Pawson Tony; Gallinger Steven; Pals Steven; Clevers Hans
EphB receptor activity suppresses colorectal cancer progression.
Nature 2005;435(7045):1126-30.
2005: van Es Johan H; van Gijn Marielle E; Riccio Orbicia; van den Born Maaike; Vooijs Marc; Begthel Harry; Cozijnsen Miranda; Robine Sylvie; Winton Doug J; Radtke Freddy; Clevers Hans
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Nature 2005;435(7044):959-63.
2005: Pinto Daniel; Clevers Hans
Wnt control of stem cells and differentiation in the intestinal epithelium.
Experimental cell research 2005;306(2):357-63.
2005: Glass Donald A; Bialek Peter; Ahn Jong Deok; Starbuck Michael; Patel Millan S; Clevers Hans; Taketo Mark M; Long Fanxin; McMahon Andrew P; Lang Richard A; Karsenty Gerard
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Developmental cell 2005;8(5):751-64.
2005: Forcet Christelle; Etienne-Manneville Sandrine; Gaude Hélène; Fournier Laurence; Debilly Sébastien; Salmi Marko; Baas Annette; Olschwang Sylviane; Clevers Hans; Billaud Marc
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
Human molecular genetics 2005;14(10):1283-92.
2005: Gregorieff Alex; Clevers Hans
Wnt signaling in the intestinal epithelium: from endoderm to cancer.
Genes & development 2005;19(8):877-90.
2005: Reya Tannishtha; Clevers Hans
Wnt signalling in stem cells and cancer.
Nature 2005;434(7035):843-50.
2005: van Es Johan H; Jay Philippe; Gregorieff Alex; van Gijn Marielle E; Jonkheer Suzanne; Hatzis Pantelis; Thiele Andrea; van den Born Maaike; Begthel Harry; Brabletz Thomas; Taketo Makoto M; Clevers Hans
Wnt signalling induces maturation of Paneth cells in intestinal crypts.
Nature cell biology 2005;7(4):381-6.
2005: Radtke Freddy; Clevers Hans
Self-renewal and cancer of the gut: two sides of a coin.
Science (New York, N.Y.) 2005;307(5717):1904-9.
2005: Pinto Daniel; Clevers Hans
Wnt, stem cells and cancer in the intestine.
Biology of the cell / under the auspices of the European Cell Biology Organization 2005;97(3):185-96.
2005: Laoukili Jamila; Kooistra Matthijs R H; Brás Alexandra; Kauw Jos; Kerkhoven Ron M; Morrison Ashby; Clevers Hans; Medema René H
FoxM1 is required for execution of the mitotic programme and chromosome stability.
Nature cell biology 2005;7(2):126-36.
2005: Staal Frank J T; Clevers Hans C
WNT signalling and haematopoiesis: a WNT-WNT situation.
Nature reviews. Immunology 2005;5(1):21-30.
2004: Clevers Hans
At the crossroads of inflammation and cancer.
Cell 2004;118(6):671-4.
2004: Clevers Hans
Signaling mucins in the (S)limelight.
Developmental cell 2004;7(2):150-1.
2004: Boersma-Vreugdenhil Gienke R; Kuipers Jeroen; Van Stralen Esther; Peeters Ton; Michaux Lucienne; Hagemeijer Anne; Pearson Peter L; Clevers Hans C; Bast Bert J E G
The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint.
British journal of haematology 2004;126(3):355-63.
2004: Blache Philippe; van de Wetering Marc; Duluc Isabelle; Domon Claire; Berta Philippe; Freund Jean-Noël; Clevers Hans; Jay Philippe
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.
The Journal of cell biology 2004;166(1):37-47.
2004: Sansom Owen J; Reed Karen R; Hayes Anthony J; Ireland Heather; Brinkmann Hannah; Newton Ian P; Batlle Eduard; Simon-Assmann Patricia; Clevers Hans; Nathke Inke S; Clarke Alan R; Winton Douglas J
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Genes & development 2004;18(12):1385-90.
2004: Baas Annette F; Smit Linda; Clevers Hans
LKB1 tumor suppressor protein: PARtaker in cell polarity.
Trends in cell biology 2004;14(6):312-9.
2004: Clevers Hans
Wnt signaling: Ig-norrin the dogma.
Current biology : CB 2004;14(11):R436-7.
2004: Le Ngoc Hang; van der Bent Paola; Huls Gerwin; van de Wetering Marc; Loghman-Adham Mahmoud; Ong Albert C M; Calvet James P; Clevers Hans; Breuning Martijn H; van Dam Hans; Peters Dorien J M
Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected.
The Journal of biological chemistry 2004;279(26):27472-81.
2004: Derksen Patrick W B; Tjin Esther; Meijer Helen P; Klok Melanie D; MacGillavry Harold D; van Oers Marinus H J; Lokhorst Henk M; Bloem Andries C; Clevers Hans; Nusse Roel; van der Neut Ronald; Spaargaren Marcel; Pals Steven T
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6122-7.
2004: Gregorieff Alex; Grosschedl Rudolf; Clevers Hans
Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.
The EMBO journal 2004;23(8):1825-33.
2004: Smit Linda; Baas Annette; Kuipers Jeroen; Korswagen Hendrik; van de Wetering Marc; Clevers Hans
Wnt activates the Tak1/Nemo-like kinase pathway.
The Journal of biological chemistry 2004;279(17):17232-40.
2004: Haramis Anna-Pavlina G; Begthel Harry; van den Born Maaike; van Es Johan; Jonkheer Suzanne; Offerhaus G Johan A; Clevers Hans
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.
Science (New York, N.Y.) 2004;303(5664):1684-6.
2004: Baas Annette F; Kuipers Jeroen; van der Wel Nicole N; Batlle Eduard; Koerten Henk K; Peters Peter J; Clevers Hans C
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.
Cell 2004;116(3):457-66.
2004: Clevers Hans
Wnt breakers in colon cancer.
Cancer cell 2004;5(1):5-6.
2004: Sancho Elena; Batlle Eduard; Clevers Hans
Signaling pathways in intestinal development and cancer.
Annual review of cell and developmental biology 2004;20():695-723.
2003: Sancho Elena; Batlle Eduard; Clevers Hans
Live and let die in the intestinal epithelium.
Current opinion in cell biology 2003;15(6):763-70.
2003: Morkel Markus; Huelsken Joerg; Wakamiya Maki; Ding Jixiang; van de Wetering Marc; Clevers Hans; Taketo Makoto M; Behringer Richard R; Shen Michael M; Birchmeier Walter
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Development (Cambridge, England) 2003;130(25):6283-94.
2003: Verbrugge Annelies; Ruiter Td Talitha de; Clevers Hans; Meyaard Linde
Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.
International immunology 2003;15(11):1349-58.
2003: Brinkmeier Michelle L; Potok Mary Anne; Cha Kelly B; Gridley Thomas; Stifani Stefano; Meeldijk Jan; Clevers Hans; Camper Sally A
TCF and Groucho-related genes influence pituitary growth and development.
Molecular endocrinology (Baltimore, Md.) 2003;17(11):2152-61.
2003: Hurlstone Adam F L; Haramis Anna-Pavlina G; Wienholds Erno; Begthel Harry; Korving Jeroen; Van Eeden Fredericus; Cuppen Edwin; Zivkovic Danica; Plasterk Ronald H A; Clevers Hans
The Wnt/beta-catenin pathway regulates cardiac valve formation.
Nature 2003;425(6958):633-7.
2003: Meyaard L; van der Vuurst de Vries A-R; de Ruiter T; Lanier L L; Phillips J H; Clevers H
Retraction.
The Journal of experimental medicine 2003;198(7):1129.
2003: Boudeau Jérôme; Baas Annette F; Deak Maria; Morrice Nick A; Kieloch Agnieszka; Schutkowski Mike; Prescott Alan R; Clevers Hans C; Alessi Dario R
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
The EMBO journal 2003;22(19):5102-14.
2003: Clevers Hans
Thymocyte development: drama without Brahma.
Immunity 2003;19(2):157-8.
2003: Kim Paul J; Plescia Janet; Clevers Hans; Fearon Eric R; Altieri Dario C
Survivin and molecular pathogenesis of colorectal cancer.
Lancet 2003;362(9379):205-9.
2003: Pinto Daniel; Gregorieff Alex; Begthel Harry; Clevers Hans
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.
Genes & development 2003;17(14):1709-13.
2003: Baas A F; Boudeau J; Sapkota G P; Smit L; Medema R; Morrice N A; Alessi D R; Clevers H C
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
The EMBO journal 2003;22(12):3062-72.
2003: Giles Rachel H; van Es Johan H; Clevers Hans
Caught up in a Wnt storm: Wnt signaling in cancer.
Biochimica et biophysica acta 2003;1653(1):1-24.
2003: van de Wetering Marc; Oving Irma; Muncan Vanesa; Pon Fong Menno Tjon; Brantjes Helen; van Leenen Dik; Holstege Frank C P; Brummelkamp Thijn R; Agami Reuven; Clevers Hans
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
EMBO reports 2003;4(6):609-15.
2003: Held Werner; Clevers Hans; Grosschedl Rudolf
Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition.
European journal of immunology 2003;33(5):1393-8.
2003: Staal Frank J T; Clevers Hans C
Wnt signaling in the thymus.
Current opinion in immunology 2003;15(2):204-8.
2003: Bienz Mariann; Clevers Hans
Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?
Nature cell biology 2003;5(3):179-82.
2003: Nicolas Michael; Wolfer Anita; Raj Kenneth; Kummer J Alain; Mill Pleasantine; van Noort Mascha; Hui Chi-chung; Clevers Hans; Dotto G Paolo; Radtke Freddy
Notch1 functions as a tumor suppressor in mouse skin.
Nature genetics 2003;33(3):416-21.
2003: van Es Johan H; Barker Nick; Clevers Hans
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.
Current opinion in genetics & development 2003;13(1):28-33.
2002: Clevers Hans
Inflating cell numbers by Wnt.
Molecular cell 2002;10(6):1260-1.
2002: Batlle Eduard; Henderson Jeffrey T; Beghtel Harry; van den Born Maaike M W; Sancho Elena; Huls Gerwin; Meeldijk Jan; Robertson Jennifer; van de Wetering Marc; Pawson Tony; Clevers Hans
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Cell 2002;111(2):251-63.
2002: van de Wetering Marc; Sancho Elena; Verweij Cornelis; de Lau Wim; Oving Irma; Hurlstone Adam; van der Horn Karin; Batlle Eduard; Coudreuse Damien; Haramis Anna Pavlina; Tjon-Pon-Fong Menno; Moerer Petra; van den Born Maaike; Soete Gwen; Pals Steven; Eilers Martin; Medema Rene; Clevers Hans
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Cell 2002;111(2):241-50.
2002: Boon Elles M J; van der Neut Ronald; van de Wetering Marc; Clevers Hans; Pals Steven T
Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer.
Cancer research 2002;62(18):5126-8.
2002: Gallagher Ronald C J; Hay Trevor; Meniel Valerie; Naughton Catherine; Anderson Thomas J; Shibata Hiroyuki; Ito Masaki; Clevers Hans; Noda Tetsuo; Sansom Owen J; Mason John O; Clarke Alan R
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.
Oncogene 2002;21(42):6446-57.
2002: Oving Irma M; Clevers Hans C
Molecular causes of colon cancer.
European journal of clinical investigation 2002;32(6):448-57.
2002: van Noort Mascha; van de Wetering Marc; Clevers Hans
Identification of two novel regulated serines in the N terminus of beta-catenin.
Experimental cell research 2002;276(2):264-72.
2002: Korswagen Hendrik C; Coudreuse Damien Y M; Betist Marco C; van de Water Sandra; Zivkovic Danica; Clevers Hans C
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
Genes & development 2002;16(10):1291-302.
2002: Hurlstone Adam; Clevers Hans
T-cell factors: turn-ons and turn-offs.
The EMBO journal 2002;21(10):2303-11.
2002: Hurlstone Adam F L; Olave Ivan A; Barker Nick; van Noort Mascha; Clevers Hans
Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.
The Biochemical journal 2002;364(Pt 1):255-64.
2002: Cheon Sophia S; Cheah Alexander Y L; Turley Stefanie; Nadesan Puviindran; Poon Raymond; Clevers Hans; Alman Benjamin A
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6973-8.
2002: van Noort Mascha; Meeldijk Jan; van der Zee Ruurd; Destree Olivier; Clevers Hans
Wnt signaling controls the phosphorylation status of beta-catenin.
The Journal of biological chemistry 2002;277(20):17901-5.
2002: van de Wetering Marc; de Lau Wim; Clevers Hans
WNT signaling and lymphocyte development.
Cell 2002;109 Suppl():S13-9.
2002: van Noort Mascha; Clevers Hans
TCF transcription factors, mediators of Wnt-signaling in development and cancer.
Developmental biology 2002;244(1):1-8.
2002: Brantjes Helen; Barker Nick; van Es Johan; Clevers Hans
TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.
Biological chemistry 2002;383(2):255-61.
2002: Lustig Barbara; Jerchow Boris; Sachs Martin; Weiler Sigrid; Pietsch Torsten; Karsten Uwe; van de Wetering Marc; Clevers Hans; Schlag Peter M; Birchmeier Walter; Behrens Jürgen
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Molecular and cellular biology 2002;22(4):1184-93.
2002: Staal Frank J T; Noort Mv Mascha van; Strous Ger J; Clevers Hans C
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
EMBO reports 2002;3(1):63-8.
2001: Fodde R; Smits R; Clevers H
APC, signal transduction and genetic instability in colorectal cancer.
Nature reviews. Cancer 2001;1(1):55-67.
2001: van de Water S; van de Wetering M; Joore J; Esseling J; Bink R; Clevers H; Zivkovic D
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.
Development (Cambridge, England) 2001;128(20):3877-88.
2001: Barker N; Hurlstone A; Musisi H; Miles A; Bienz M; Clevers H
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.
The EMBO journal 2001;20(17):4935-43.
2001: Ioannidis V; Beermann F; Clevers H; Held W
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
Nature immunology 2001;2(8):691-7.
2001: Meyaard L; van der Vuurst de Vries A R; de Ruiter T; Lanier L L; Phillips J H; Clevers H
The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).
The Journal of experimental medicine 2001;194(1):107-12.
2001: Fodde R; Kuipers J; Rosenberg C; Smits R; Kielman M; Gaspar C; van Es J H; Breukel C; Wiegant J; Giles R H; Clevers H
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Nature cell biology 2001;3(4):433-8.
2001: Brantjes H; Roose J; van De Wetering M; Clevers H
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
Nucleic acids research 2001;29(7):1410-9.
2001: van Es J H; Giles R H; Clevers H C
The many faces of the tumor suppressor gene APC.
Experimental cell research 2001;264(1):126-34.
2001: Staal F J; Clevers H C
Regulation of lineage commitment during lymphocyte development.
International reviews of immunology 2001;20(1):45-64.
2001: Staal F J; Meeldijk J; Moerer P; Jay P; van de Weerdt B C; Vainio S; Nolan G P; Clevers H
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.
European journal of immunology 2001;31(1):285-93.
2001: van de Wetering M; Barker N; Harkes I C; van der Heyden M; Dijk N J; Hollestelle A; Klijn J G; Clevers H; Schutte M
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
Cancer research 2001;61(1):278-84.
2001: Staal F J; Weerkamp F; Langerak A W; Hendriks R W; Clevers H C
Transcriptional control of t lymphocyte differentiation.
Stem cells (Dayton, Ohio) 2001;19(3):165-79.
2000: Barker N; Clevers H
Catenins, Wnt signaling and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(11):961-5.
2000: Lickert H; Domon C; Huls G; Wehrle C; Duluc I; Clevers H; Meyer B I; Freund J N; Kemler R
Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.
Development (Cambridge, England) 2000;127(17):3805-13.
2000: Yang X; van Beest M; Clevers H; Jones T; Hursh D A; Mortin M A
decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm.
Development (Cambridge, England) 2000;127(17):3695-702.
2000: van Beest M; Dooijes D; van De Wetering M; Kjaerulff S; Bonvin A; Nielsen O; Clevers H
Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.
The Journal of biological chemistry 2000;275(35):27266-73.
2000: Korswagen H C; Herman M A; Clevers H C
Distinct beta-catenins mediate adhesion and signalling functions in C. elegans.
Nature 2000;406(6795):527-32.
2000: Molenaar M; Brian E; Roose J; Clevers H; Destrée O
Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis.
Mechanisms of development 2000;91(1-2):311-5.
2000: Barker N; Morin P J; Clevers H
The Yin-Yang of TCF/beta-catenin signaling.
Advances in cancer research 2000;77():1-24.
1999: Held W; Kunz B; Lowin-Kropf B; van de Wetering M; Clevers H
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
Immunity 1999;11(4):433-42.
1999: van der Vuurst de Vries A R; Clevers H; Logtenberg T; Meyaard L
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.
European journal of immunology 1999;29(10):3160-7.
1999: Roose J; Clevers H
TCF transcription factors: molecular switches in carcinogenesis.
Biochimica et biophysica acta 1999;1424(2-3):M23-37.
1999: Roose J; Huls G; van Beest M; Moerer P; van der Horn K; Goldschmeding R; Logtenberg T; Clevers H
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science (New York, N.Y.) 1999;285(5435):1923-6.
1999: Meyaard L; Hurenkamp J; Clevers H; Lanier L L; Phillips J H
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5800-4.
1999: Roose J; Korver W; de Boer R; Kuipers J; Hurenkamp J; Clevers H
The Sox-13 gene: structure, promoter characterization, and chromosomal localization.
Genomics 1999;57(2):301-5.
1999: Staal F J; Burgering B M; van de Wetering M; Clevers H C
Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.
International immunology 1999;11(3):317-23.
1999: Kuipers J; Vaandrager J W; Weghuis D O; Pearson P L; Scheres J; Lokhorst H M; Clevers H; Bast B J
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
Cancer genetics and cytogenetics 1999;109(2):99-107.
1999: Wielenga V J; Smits R; Korinek V; Smit L; Kielman M; Fodde R; Clevers H; Pals S T
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.
The American journal of pathology 1999;154(2):515-23.
1999: van Es J H; Kirkpatrick C; van de Wetering M; Molenaar M; Miles A; Kuipers J; Destrée O; Peifer M; Clevers H
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Current biology : CB 1999;9(2):105-8.
1999: Barker N; Huls G; Korinek V; Clevers H
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.
The American journal of pathology 1999;154(1):29-35.
1999: Korswagen H C; Clevers H C
Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors.
Cold Spring Harbor symposia on quantitative biology 1999;64():141-7.
1998: Korver W; Schilham M W; Moerer P; van den Hoff M J; Dam K; Lamers W H; Medema R H; Clevers H
Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident.
Current biology : CB 1998;8(24):1327-30.
1998: Ya J; Schilham M W; de Boer P A; Moorman A F; Clevers H; Lamers W H
Sox4-deficiency syndrome in mice is an animal model for common trunk.
Circulation research 1998;83(10):986-94.
1998: Roose J; Molenaar M; Peterson J; Hurenkamp J; Brantjes H; Moerer P; van de Wetering M; Destrée O; Clevers H
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.
Nature 1998;395(6702):608-12.
1998: Cavallo R A; Cox R T; Moline M M; Roose J; Polevoy G A; Clevers H; Peifer M; Bejsovec A
Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
Nature 1998;395(6702):604-8.
1998: Schilham M W; Wilson A; Moerer P; Benaissa-Trouw B J; Cumano A; Clevers H C
Critical involvement of Tcf-1 in expansion of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3984-91.
1998: van Beest M; Mortin M; Clevers H
Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF.
Nucleic acids research 1998;26(19):4471-5.
1998: Korinek V; Barker N; Moerer P; van Donselaar E; Huls G; Peters P J; Clevers H
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Nature genetics 1998;19(4):379-83.
1998: Molenaar M; Roose J; Peterson J; Venanzi S; Clevers H; Destrée O
Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development.
Mechanisms of development 1998;75(1-2):151-4.
1998: Schilham M W; Clevers H
HMG box containing transcription factors in lymphocyte differentiation.
Seminars in immunology 1998;10(2):127-32.
1998: Dooijes D; van Beest M; van de Wetering M; Boulanger G; Jones T; Clevers H; Mortin M A
Genomic organization of the segment polarity gene pan in Drosophila melanogaster.
Molecular & general genetics : MGG 1998;258(1-2):45-52.
1998: Clevers H; Ferrier P
Transcriptional control during T-cell development.
Current opinion in immunology 1998;10(2):166-71.
1998: Korinek V; Barker N; Willert K; Molenaar M; Roose J; Wagenaar G; Markman M; Lamers W; Destree O; Clevers H
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.
Molecular and cellular biology 1998;18(3):1248-56.
1998: de Lau W B; Kuipers J; Peters P J; Lokhorst H M; Clevers H; Bast B J
Putative myeloma precursor cells expressing 2,6 sialic acid-modified antigens actually belong to the erythroid lineage.
Leukemia research 1998;22(2):163-73.
1998: Roose J; Korver W; Oving E; Wilson A; Wagenaar G; Markman M; Lamers W; Clevers H
High expression of the HMG box factor sox-13 in arterial walls during embryonic development.
Nucleic acids research 1998;26(2):469-76.
1997: Korver W; Roose J; Wilson A; Clevers H
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
Immunobiology 1997;198(1-3):157-61.
1997: Korver W; Roose J; Heinen K; Weghuis D O; de Bruijn D; van Kessel A G; Clevers H
The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.
Genomics 1997;46(3):435-42.
1997: Clevers H; van de Wetering M
TCF/LEF factor earn their wings.
Trends in genetics : TIG 1997;13(12):485-9.
1997: Ya J; Schilham M W; Clevers H; Moorman A F; Lamers W H
Animal models of congenital defects in the ventriculoarterial connection of the heart.
Journal of molecular medicine (Berlin, Germany) 1997;75(8):551-66.
1997: Kjaerulff S; Dooijes D; Clevers H; Nielsen O
Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.
The EMBO journal 1997;16(13):4021-33.
1997: Dooijes D; Clevers H
Control of gene expression during lymphoid development: targeted gene disruption provides new clues.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(5):337-44.
1997: Schilham M W; Moerer P; Cumano A; Clevers H C
Sox-4 facilitates thymocyte differentiation.
European journal of immunology 1997;27(5):1292-5.
1997: Korver W; Roose J; Clevers H
The winged-helix transcription factor Trident is expressed in cycling cells.
Nucleic acids research 1997;25(9):1715-9.
1997: van de Wetering M; Cavallo R; Dooijes D; van Beest M; van Es J; Loureiro J; Ypma A; Hursh D; Jones T; Bejsovec A; Peifer M; Mortin M; Clevers H
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
Cell 1997;88(6):789-99.
1997: Morin P J; Sparks A B; Korinek V; Barker N; Clevers H; Vogelstein B; Kinzler K W
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Science (New York, N.Y.) 1997;275(5307):1787-90.
1997: Korinek V; Barker N; Morin P J; van Wichen D; de Weger R; Kinzler K W; Vogelstein B; Clevers H
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Science (New York, N.Y.) 1997;275(5307):1784-7.
1996: Santos M; Schilham M W; Rademakers L H; Marx J J; de Sousa M; Clevers H
Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.
The Journal of experimental medicine 1996;184(5):1975-85.
1996: Petersen E J; Rozenberg-Arska M; Dekker A W; Clevers H C; Verdonck L F
Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia.
Bone marrow transplantation 1996;18(4):813-5.
1996: Molenaar M; van de Wetering M; Oosterwegel M; Peterson-Maduro J; Godsave S; Korinek V; Roose J; Destrée O; Clevers H
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
Cell 1996;86(3):391-9.
1996: Schilham M W; Oosterwegel M A; Moerer P; Ya J; de Boer P A; van de Wetering M; Verbeek S; Lamers W H; Kruisbeek A M; Cumano A; Clevers H
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4.
Nature 1996;380(6576):711-4.
1996: Van de Wetering M; Castrop J; Korinek V; Clevers H
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.
Molecular and cellular biology 1996;16(3):745-52.
1996: Ohteki T; Wilson A; Verbeek S; MacDonald H R; Clevers H
Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice.
European journal of immunology 1996;26(2):351-5.
1995: van Houte L P; Chuprina V P; van der Wetering M; Boelens R; Kaptein R; Clevers H
Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4.
The Journal of biological chemistry 1995;270(51):30516-24.
1995: Castrop J; van Wichen D; Koomans-Bitter M; van de Wetering M; de Weger R; van Dongen J; Clevers H
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.
Blood 1995;86(8):3050-9.
1995: Mayer K; Wolff E; Clevers H; Ballhausen W G
The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.
Biochimica et biophysica acta 1995;1263(2):169-72.
1995: Toye P G; Metzelaar M J; Wijngaard P L; Nene V; Iams K; Roose J; Nyanjui J K; Gobright E; Musoke A J; Clevers H C
Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1370-81.
1995: Castrop J; Verbeek S; Hofhuis F; Clevers H
Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.
Immunobiology 1995;193(2-4):281-7.
1995: Scheffer G L; Wijngaard P L; Flens M J; Izquierdo M A; Slovak M L; Pinedo H M; Meijer C J; Clevers H C; Scheper R J
The drug resistance-related protein LRP is the human major vault protein.
Nature medicine 1995;1(6):578-82.
1995: Verbeek S; Izon D; Hofhuis F; Robanus-Maandag E; te Riele H; van de Wetering M; Oosterwegel M; Wilson A; MacDonald H R; Clevers H
An HMG-box-containing T-cell factor required for thymocyte differentiation.
Nature 1995;374(6517):70-4.
1994: Walker I D; Glew M D; O'Keeffe M A; Metcalfe S A; Clevers H C; Wijngaard P L; Adams T E; Hein W R
A novel multi-gene family of sheep gamma delta T cells.
Immunology 1994;83(4):517-23.
1994: Wijngaard P L; MacHugh N D; Metzelaar M J; Romberg S; Bensaid A; Pepin L; Davis W C; Clevers H C
Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3476-82.
1993: Dooijes D; van de Wetering M; Knippels L; Clevers H
The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.
The Journal of biological chemistry 1993;268(33):24813-7.
1993: MacHugh N D; Wijngaard P L; Clevers H C; Davis W C
Clustering of monoclonal antibodies recognizing different members of the WC1 gene family.
Veterinary immunology and immunopathology 1993;39(1-3):155-60.
1993: van de Wetering M; Oosterwegel M; van Norren K; Clevers H
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.
The EMBO journal 1993;12(10):3847-54.
1993: Oosterwegel M; van de Wetering M; Clevers H
HMG box proteins in early T-cell differentiation.
Thymus 1993;22(2):67-81.
1993: van Houte L; van Oers A; van de Wetering M; Dooijes D; Kaptein R; Clevers H
The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution.
The Journal of biological chemistry 1993;268(24):18083-7.
1993: De Lau W B; Kuipers J; Voshol H; Clevers H; Bast B J
HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):4911-9.
1993: Oosterwegel M; van de Wetering M; Timmerman J; Kruisbeek A; Destree O; Meijlink F; Clevers H
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis.
Development (Cambridge, England) 1993;118(2):439-48.
1993: Schilham M W; van Eijk M; van de Wetering M; Clevers H C
The murine Sox-4 protein is encoded on a single exon.
Nucleic acids research 1993;21(8):2009.
1993: van de Wetering M; Clevers H
Sox 15, a novel member of the murine Sox family of HMG box transcription factors.
Nucleic acids research 1993;21(7):1669.
1992: Wijngaard P L; Metzelaar M J; MacHugh N D; Morrison W I; Clevers H C
Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3273-7.
1992: Metzelaar M J; Clevers H C
Lysosomal membrane glycoproteins in platelets.
Thrombosis and haemostasis 1992;68(4):378-82.
1992: De Lau W B; Boom S E; Heije K; Griffioen A W; Braakman E; Bolhuis R L; Tax W J; Clevers H; Bast B J
Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):1840-6.
1992: van de Wetering M; Clevers H
Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.
The EMBO journal 1992;11(8):3039-44.
1992: Gastrop J; Hoevenagel R; Young J R; Clevers H C
A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF-1 expressed in chicken T cells.
European journal of immunology 1992;22(5):1327-30.
1992: van de Wetering M; Oosterwegel M; Holstege F; Dooyes D; Suijkerbuijk R; Geurts van Kessel A; Clevers H
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
The Journal of biological chemistry 1992;267(12):8530-6.
1992: Castrop J; van Norren K; Clevers H
A gene family of HMG-box transcription factors with homology to TCF-1.
Nucleic acids research 1992;20(3):611.
1992: Bensaid A; Kaushal A; Young J R; Baldwin C L; Clevers H; Teale A J
[Physical mapping of the major histocompatibility complex of cattle]
Annales de recherches vétérinaires. Annals of veterinary research 1992;23(3):256-8.
1992: Oosterwegel M; Timmerman J; Leiden J; Clevers H
Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis.
Developmental immunology 1992;3(1):1-11.
1991: Horst E; Wijngaard P L; Metzelaar M; Bast E J; Clevers H C
A method for cDNA cloning in COS cells irrespective of subcellular site of expression.
Nucleic acids research 1991;19(16):4556.
1991: Oosterwegel M; van de Wetering M; Dooijes D; Klomp L; Winoto A; Georgopoulos K; Meijlink F; Clevers H
Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
The Journal of experimental medicine 1991;173(5):1133-42.
1991: Metzelaar M J; Wijngaard P L; Peters P J; Sixma J J; Nieuwenhuis H K; Clevers H C
CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.
The Journal of biological chemistry 1991;266(5):3239-45.
1991: van de Wetering M; Oosterwegel M; Dooijes D; Clevers H
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.
The EMBO journal 1991;10(1):123-32.
1991: Bensaid A; Kaushal A; Baldwin C L; Clevers H; Young J R; Kemp S J; MacHugh N D; Toye P G; Teale A J
Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage.
Immunogenetics 1991;33(4):247-54.
1990: Clevers H; MacHugh N D; Bensaid A; Dunlap S; Baldwin C L; Kaushal A; Iams K; Howard C J; Morrison W I
Identification of a bovine surface antigen uniquely expressed on CD4-CD8- T cell receptor gamma/delta+ T lymphocytes.
European journal of immunology 1990;20(4):809-17.
1989: Clevers H; Lonberg N; Dunlap S; Lacy E; Terhorst C
An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter.
The EMBO journal 1989;8(9):2527-35.
1989: Peters P J; Geuze H J; Van der Donk H A; Slot J W; Griffith J M; Stam N J; Clevers H C; Borst J
Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes.
European journal of immunology 1989;19(8):1469-75.
1988: Clevers H; Dunlap S; Saito H; Georgopoulos K; Wileman T; Terhorst C
Characterization and expression of the murine CD3-epsilon gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8623-7.
1988: Clevers H; Dunlap S; Terhorst C
The transmembrane orientation of the epsilon chain of the TcR/CD3 complex.
European journal of immunology 1988;18(5):705-10.
1988: Clevers H; Alarcon B; Wileman T; Terhorst C
The T cell receptor/CD3 complex: a dynamic protein ensemble.
Annual review of immunology 1988;6():629-62.
1987: Saito H; Koyama T; Georgopoulos K; Clevers H; Haser W G; LeBien T; Tonegawa S; Terhorst C
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9131-4.
1987: Gold D P; Clevers H; Alarcon B; Dunlap S; Novotny J; Williams A F; Terhorst C
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7649-53.

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