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Hans Clevers

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Sophia Bardehle; Ingo Bechmann; Felix Buggenthin; Hans Clevers; Leda Dimou; Martin Krüger; Melanie Meyer-Luehmann; Jovica Ninkovic; Julia Schwausch; Hugo J Snippert; Fabian J Theis; Magdalena Götz
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
Jarom Heijmans; Daniël W Hommes; Liudmila L Kodach; Bon-Kyoung Koo; Amy S Lee; A Mieke Mommaas; Vanesa Muncan; Jos J M Onderwater; Adrienne W Paton; James C Paton; Sanne L Rosekrans; Marc van de Wetering; Hans Clevers; Marc Ferrante; James C H Hardwick; Jooske F van Lidth de Jeude; Mattheus C B Wielenga; Gijs R van den Brink
ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
Jinhua Lu; Haruo Nakano; Lianju Shen; David G Simmons; Zhaowei Tu; Johan H van Es; Bingyan Wang; Hongmei Wang; Hans Clevers; James C Cross; Shuangbo Kong; Gustavo Leone; Qiang Wang; Shumin Wang; Weixiang Wang; Yanling Wang; Shuang Zhang; Haibin Wang
A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta.

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All Publications

2013: Sophia Bardehle; Ingo Bechmann; Felix Buggenthin; Hans Clevers; Leda Dimou; Martin Krüger; Melanie Meyer-Luehmann; Jovica Ninkovic; Julia Schwausch; Hugo J Snippert; Fabian J Theis; Magdalena Götz
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
Nature neuroscience 2013;16(5):580-6.
2013: Jarom Heijmans; Daniël W Hommes; Liudmila L Kodach; Bon-Kyoung Koo; Amy S Lee; A Mieke Mommaas; Vanesa Muncan; Jos J M Onderwater; Adrienne W Paton; James C Paton; Sanne L Rosekrans; Marc van de Wetering; Hans Clevers; Marc Ferrante; James C H Hardwick; Jooske F van Lidth de Jeude; Mattheus C B Wielenga; Gijs R van den Brink
ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
Cell reports 2013;3(4):1128-39.
2013: Jinhua Lu; Haruo Nakano; Lianju Shen; David G Simmons; Zhaowei Tu; Johan H van Es; Bingyan Wang; Hongmei Wang; Hans Clevers; James C Cross; Shuangbo Kong; Gustavo Leone; Qiang Wang; Shumin Wang; Weixiang Wang; Yanling Wang; Shuang Zhang; Haibin Wang
A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta.
PLoS biology 2013;11(4):e1001536.
2013: Hans Clevers
Stem Cells: A unifying theory for the crypt.
Nature 2013;495(7439):53-4.
2013: Hans Clevers; Eduard Batlle
SnapShot: the intestinal crypt.
Cell 2013;152(5):1198-1198.e2.
2013: Meritxell Huch; Vivian S W Li; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Johan H van Es; Robert G J Vries; Craig Dorrell; Milton J Finegold; Markus Grompe; Annelise Haft; Karien Hamer; Sylvia F Boj; Hans Clevers
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature 2013;494(7436):247-50.
2013: Vivian S W Li; Hans Clevers
Intestinal regeneration: YAP-tumor suppressor and oncoprotein?
Current biology : CB 2013;23(3):R110-2.
2013: Alice Boilève; Maria Castedo; Hans Clevers; Lorenzo Galluzzi; Delphine Lissa; Isabelle Martins; Didier Métivier; Laura Senovilla; Stieneke van den Brink; Ilio Vitale; Guido Kroemer
Immunosurveillance against tetraploidization-induced colon tumorigenesis.
Cell cycle (Georgetown, Tex.) 2013;12(3):473-9.
2013: Lin Wang; Dagmar Zeuschner; Rui Benedito; M Gabriele Bixel; Georg Breier; Hans Clevers; Jody J Haigh; Friedemann Kiefer; Lars Sävendahl; Hugo Snippert; Martin Stehling; Ralf H Adams
Identification of a clonally expanding haematopoietic compartment in bone marrow.
The EMBO journal 2013;32(2):219-30.
2013: Sarah Schwitalla; Makoto M Taketo; Gijs R van den Brink; Paul K Ziegler; Melek C Arkan; Nick Barker; Patrizia Cammareri; Ozge Canli; Hans Clevers; Alexander A Fingerle; Markus Gerhard; Serkan I Göktuna; Jarom Heijmans; David J Huels; Thomas Kirchner; Roland Lang; Guenievre Moreaux; Tim Nebelsiek; Jens Neumann; Rudolf A Rupec; Owen J Sansom; Roland Schmid; Florian R Greten
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Cell 2013;152(1-2):25-38.
2013: Toshiro Sato; Hans Clevers
Primary mouse small intestinal epithelial cell cultures.
Methods in molecular biology (Clifton, N.J.) 2013;945():319-28.
2012: Sylvia F Boj; Pierre Chambon; Edwin Cuppen; Yuval Dor; Cristina Fillat; Andrea Haegebarth; Pantelis Hatzis; Meritxell Huch; Anabel José; Vivian S W Li; Michal Mokry; Maaike van den Born; Johan H van Es; Peter Voshol; Hans Clevers
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell 2012;151(7):1595-607.
2012: Henner F Farin; Johan H van Es; Hans Clevers
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
Gastroenterology 2012;143(6):1518-1529.e7.
2012: Frank J T Staal; Hans Clevers
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.
Immunity 2012;37(5):761-3.
2012: Kristel Kemper; Hans Clevers; Wim De Lau; Pramudita R Prasetyanti; Hans M Rodermond; Jan Paul Medema
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells.
Stem cells (Dayton, Ohio) 2012;30(11):2378-86.
2012: Karin E de Visser; Cheei-Sing Hau; Nick Barker; Metamia Ciampricotti; Hans Clevers; Ewa M Michalak; Ewoud N Speksnijder; David Wei-Min Tan; Jos Jonkers
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland.
The Journal of pathology 2012;228(3):300-9.
2012: Guoqiang Hua; Tin Htwe Thin; Hans Clevers; Regina Feldman; Zvi Fuks; Adriana Haimovitz-Friedman; Richard Kolesnick
Crypt base columnar stem cells in small intestines of mice are radioresistant.
Gastroenterology 2012;143(5):1266-76.
2012: Nick Barker; Alexander van Oudenaarden; Hans Clevers
Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
Cell stem cell 2012;11(4):452-60.
2012: Johan H van Es; Alexander van Oudenaarden; Laura Zeinstra; Annie Ng Yee Nee; Nick Barker; Alex Gregorieff; Jeroen Korving; Anna Lyubimova; Anton C M Martens; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Maaike van den Born; Hans Clevers
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Nature cell biology 2012;14(10):1099-104.
2012: Nick Barker; Meritxell Huch; Pekka Kujala; Marc Leushacke; Annie Ng; Peter J Peters; Richard Poulsom; Maarten B Rookmaaker; Hugo Snippert; Shawna Tan; Marc van de Wetering; Johan H van Es; Marianne C Verhaar; Hans Clevers
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Cell reports 2012;2(3):540-52.
2012: Arie Abo; Hans Clevers
Modulating WNT receptor turnover for tissue repair.
Nature biotechnology 2012;30(9):835-6.
2012: Wim de Lau; Rodney P DeKoter; Frans Hofhuis; Pekka Kujala; Vivian S W Li; Anton Martens; Sabine Middendorp; Edward Nieuwenhuis; Peter J Peters; Kerstin Schneeberger; Nick Barker; Hans Clevers
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Molecular and cellular biology 2012;32(18):3639-47.
2012: Peter Buske; Hans Clevers; Markus Loeffler; Jens Przybilla; Norman Sachs; Toshiro Sato; Joerg Galle
On the biomechanics of stem cell niche formation in the gut--modelling growing organoids.
The FEBS journal 2012;279(18):3475-87.
2012: Bon-Kyoung Koo; Teck Y Low; Madelon M Maurice; shabaz mohammed; Maureen Spit; Daniel E Stange; Marc van de Wetering; Johan H van Es; Albert J R Heck; Ingrid Jordens; Hans Clevers
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Nature 2012;488(7413):665-9.
2012: Helena Shaked; Steve Shenouda; Koji Taniguchi; Jin Wang; Yinsheng Wang; Alena Chumanevich; Alexander A Chumanevich; Hans Clevers; Monica Guma; Curtis C Harris; Lorne J Hofseth; Michael Karin
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14007-12.
2012: Lawrence Lum; Hans Clevers
Cell biology. The unusual case of Porcupine.
Science (New York, N.Y.) 2012;337(6097):922-3.
2012: Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Marc van de Wetering; Maaike van den Born; Johan H van Es; Hans Clevers
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.
Science (New York, N.Y.) 2012;337(6095):730-5.
2012: Martijn Gloerich; Thijs Koorman; Jean Paul ten Klooster; Marjolein J Vliem; Fried J Zwartkruis; Hans Clevers; Johannes L Bos
Rap2A links intestinal cell polarity to brush border formation.
Nature cell biology 2012;14(8):793-801.
2012: Tatsuo Hashimoto; Hiroaki Ishiguro; Keiji Kuba; Simone Lipinski; Magdalena Paolino; Simone M R Camargo; Hans Clevers; Akiyoshi Fukamizu; Reiko Hanada; Toshikatsu Hanada; Thomas Perlot; Ateequr Rehman; Andreas Richter; Philip Rosenstiel; Stefan Schreiber; Verena Sigl; Dustin Singer; Jean Trichereau; Francois Verrey; Birgit Wild; Josef M Penninger
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Nature 2012;487(7408):477-81.
2012: Javier Muñoz; Kevin Myant; Sorina Radulescu; Owen J Sansom; Arnout G Schepers; Daniel E Stange; Marc van de Wetering; Johan H van Es; Alexander van Oudenaarden; Rogier Versteeg; Richard Volckmann; Albert J R Heck; Shalev Itzkovitz; Bon-Kyoung Koo; Jan Koster; Kevin S Kung; shabaz mohammed; Nick Barker; Hans Clevers
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
The EMBO journal 2012;31(14):3079-91.
2012: Vivian S W Li; Hans Clevers
In vitro expansion and transplantation of intestinal crypt stem cells.
Gastroenterology 2012;143(1):30-4.
2012: Jurian Schuijers; Hans Clevers
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.
The EMBO journal 2012;31(12):2685-96.
2012: Vivian S W Li; Teck Y Low; Tokameh Mahmoudi; Madelon M Maurice; shabaz mohammed; Ser Sue Ng; Paul J Boersema; Jan P Gerlach; Albert J R Heck; Wouter R Karthaus; Hans Clevers
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Cell 2012;149(6):1245-56.
2012: Hans Clevers; Roel Nusse
Wnt/β-catenin signaling and disease.
Cell 2012;149(6):1192-205.
2012: Johan H van Es; Alexander van Oudenaarden; Sylvia F Boj; Andrea Haegebarth; Shalev Itzkovitz; Bon-Kyoung Koo; Jeroen Korving; Pekka Kujala; Sylvie Robine; Maaike van den Born; Hans Clevers
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
Molecular and cellular biology 2012;32(10):1918-27.
2012: Daniele Guardavaccaro; Hans Clevers
Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.
Science signaling 2012;5(219):pe15.
2012: Arnout Schepers; Hans Clevers
Wnt signaling, stem cells, and cancer of the gastrointestinal tract.
Cold Spring Harbor perspectives in biology 2012;4(4):a007989.
2012: Shiro Yui; Xiu Zheng; Hans Clevers; Shizuko Ichinose; Tomohiro Mizutani; Takashi Nagaishi; Tetsuya Nakamura; Yasuhiro Nemoto; Ryuichi Okamoto; Toshiro Sato; Kiichiro Tsuchiya; Mamoru Watanabe
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.
Nature medicine 2012;18(4):618-23.
2012: Vivian W Y Wong; Nicholas A Wright; Simon Buczacki; Hans Clevers; Satoshi Itami; Mahalia E Page; Richard Poulsom; Daniel E Stange; Matthew W B Trotter; Marc van de Wetering; Agnieszka Wabik; Fiona M Watt; Douglas J Winton; Kim B Jensen
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Nature cell biology 2012;14(4):401-8.
2012: Richard B M Schasfoort; Alex van der Kooi; Wim de Lau; Hans Clevers; Gerard H M Engbers
Method for estimating the single molecular affinity.
Analytical biochemistry 2012;421(2):794-6.
2012: Shalev Itzkovitz; Tyler Jacks; Irene C Blat; Hans Clevers; Alexander van Oudenaarden
Optimality in the development of intestinal crypts.
Cell 2012;148(3):608-19.
2012: Machteld M Tiemessen; Jacques J M van Dongen; Miranda R M Baert; Martijn Brugman; Hans Clevers; Farbod Famili; Jules P P Meijerink; Ugur Ozbek; Daniela C F Salvatori; Tom Schonewille; Frank J T Staal
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
PLoS biology 2012;10(11):e1001430.
2012: Arthur D Lander; Didier Montarras; Andreas Trumpp; Margaret Buckingham; Anne L Calof; Hans Clevers; Elaine Fuchs; Judith Kimble; Thordur Oskarsson
What does the concept of the stem cell niche really mean today?
BMC biology 2012;10():19.
2011: Winan J van Houdt; André Verheem; Robert G J Vries; T V Pham; Sander R Piersma; A Pronk; I H M Borel Rinkes; Hans Clevers; B L Emmink; S A Fratantoni; Connie R Jimenez; Onno Kranenburg
Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target.
Molecular & cellular proteomics : MCP 2011;10(12):M111.011353.
2011: Benjamin D Simons; Hans Clevers
Stem cell self-renewal in intestinal crypt.
Experimental cell research 2011;317(19):2719-24.
2011: Toshiro Sato; Peter D Siersema; Daniel E Stange; Stieneke van den Brink; Johan H van Es; Joost Van Gorp; Winan J van Houdt; Robert G J Vries; Marc Ferrante; Apollo Pronk; Hans Clevers
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.
Gastroenterology 2011;141(5):1762-72.
2011: Peter Jung; Anna Merlos-Suárez; David Rossell; Elena Sancho; Toshiro Sato; Maria A Blasco; Hans Clevers; Mercedes Gallardo; Mar Iglesias; Herbert Auer; Francisco M Barriga; Eduard Batlle
Isolation and in vitro expansion of human colonic stem cells.
Nature medicine 2011;17(10):1225-7.
2011: Fieke E M Froeling; Ian R Hart; Charles E Mein; David A Tuveson; Claude Chelala; Hans Clevers; Richard Dobson; Christine Feig; Hemant M Kocher
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.
Gastroenterology 2011;141(4):1486-97, 1497.e1-14.
2011: Wim de Lau; Daniele Guardavaccaro; Andrea Haegebarth; Albert J R Heck; Bon-Kyoung Koo; Pekka Kujala; Vivian S W Li; Teck Y Low; shabaz mohammed; Yasuaki Mohri; Katsuhiko Nishimori; Peter J Peters; Richard B M Schasfoort; Daniel E Stange; Hans Teunissen; Marc van de Wetering; Johan E van Es; Nick Barker; Hans Clevers
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature 2011;476(7360):293-7.
2011: Serena Di Palma; Albert J R Heck; Daniel Stange; Marc van de Wetering; Hans Clevers; shabaz mohammed
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.
Journal of proteome research 2011;10(8):3814-9.
2011: Hugo J Snippert; Gabriele Delconte; Arnout G Schepers; Peter D Siersema; Hans Clevers
Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment.
Nature protocols 2011;6(8):1221-8.
2011: Benjamin L Emmink; Klaas M Govaert; Frederik J H Hoogwater; Connie R Jimenez; Maarten W Nijkamp; Ernst J A Steller; Winan J van Houdt; André Verheem; Robert G Vries; Inne H M Borel Rinkes; Hans Clevers; Onno Kranenburg
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.
Gastroenterology 2011;141(1):269-78.
2011: Michael S Samuel; Owen J Sansom; Ewald Schröder; David Strachan; Paul Timpson; Valerie M Weaver; Jing Zhou; Kurt I Anderson; Nick Barker; Valerie G Brunton; Hans Clevers; Daniel R Croft; Jose I Lopez; Ewan J McGhee; June Munro; Michael F Olson
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Cancer cell 2011;19(6):776-91.
2011: Benjamin D Simons; Hans Clevers
Strategies for homeostatic stem cell self-renewal in adult tissues.
Cell 2011;145(6):851-62.
2011: Anna Merlos-Suárez; Francisco M Barriga; Peter Jung; Mar Iglesias; María Virtudes Céspedes; David Rossell; Marta Sevillano; Xavier Hernando-Momblona; Victoria da Silva-Diz; Purificación Muñoz; Hans Clevers; Elena Sancho; Bafalluy Mangues; Eduard Batlle
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.
Cell stem cell 2011;8(5):511-24.
2011: Arnout G Schepers; Robert G J Vries; Maaike van den Born; Marc van de Wetering; Hans Clevers
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.
The EMBO journal 2011;30(6):1104-9.
2011: Yme U van der Velden; Liqin Wang; John Zevenhoven; Ellen van Rooijen; Maarten van Lohuizen; Rachel H Giles; Hans Clevers; Anna-Pavlina G Haramis
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4358-63.
2011: François Gerbe; Johan H van Es; Leila Makrini; Bénédicte Brulin; Georg Mellitzer; Sylvie Robine; Béatrice Romagnolo; Noah F Shroyer; Jean-François Bourgaux; Christine Pignodel; Hans Clevers; Philippe Jay
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
The Journal of cell biology 2011;192(5):767-80.
2011: Hans Clevers
The cancer stem cell: premises, promises and challenges.
Nature medicine 2011;17(3):313-9.
2011: Hugo J Snippert; Hans Clevers
Tracking adult stem cells.
EMBO reports 2011;12(2):113-22.
2011: Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature 2011;469(7330):415-8.
2011: Marc Sylva; Maaike van den Born; Saskia van der Velden; Johan H van Es; Anita A M Buffing; Hans Clevers; Quinn Gunst; Jan Harm Koolstra; Vivian S W Li; Antoon F M Moorman; Maurice J B Van Den Hoff
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.
PloS one 2011;6(8):e22616.
2011: Peter Buske; Jörg Galle; Nick Barker; Gabriela Aust; Hans Clevers; Markus Loeffler
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.
PLoS computational biology 2011;7(1):e1001045.
2011: Meritxell Huch; Hans Clevers
Sox9 marks adult organ progenitors.
Nature genetics 2011;43(1):9-10.
2011: Maud D Demarque; Karim Nacerddine; Hélène Neyret-Kahn; Alexandra Andrieux; Esther Danenberg; Grégory Jouvion; Perrine Bomme; Ghislaine Hamard; Béatrice Romagnolo; Benoît Terris; Ana Cumano; Nick Barker; Hans Clevers; Anne Dejean
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.
Gastroenterology 2011;140(1):286-96.
2010: Nick Barker; Sina Bartfeld; Hans Clevers
Tissue-resident adult stem cell populations of rapidly self-renewing organs.
Cell stem cell 2010;7(6):656-70.
2010: Wei Qiu; Xinwei Wang; Brian Leibowitz; Hongtao Liu; Nick Barker; Hitoshi Okada; Naohide Oue; Wataru Yasui; Hans Clevers; Robert E Schoen; Jian Yu; Lin Zhang
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20027-32.
2010: Gerold Bongers; David Maussang; Luciana R Muniz; Vanessa M Noriega; Alberto Fraile-Ramos; Nick Barker; Federica Marchesi; Nanthakumar Thirunarayanan; Henry F Vischer; Lihui Qin; Lloyd Mayer; Noam Harpaz; Rob Leurs; Glaucia C Furtado; Hans Clevers; Domenico Tortorella; Martine J Smit; Sergio A Lira
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.
The Journal of clinical investigation 2010;120(11):3969-78.
2010: Alicia M Cole; Rachel A Ridgway; Sahra E Derkits; Lee Parry; Nick Barker; Hans Clevers; Alan R Clarke; Owen J Sansom
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
EMBO molecular medicine 2010;2(11):472-86.
2010: Alicia M Cole; Kevin Myant; Karen R Reed; Rachel A Ridgway; Dimitris Athineos; Gijs R van den Brink; Vanesa Muncan; Hans Clevers; Alan R Clarke; Peter Sicinski; Owen J Sansom
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.
Cancer research 2010;70(20):8149-58.
2010: Hugo J Snippert; Laurens G van der Flier; Toshiro Sato; Johan H van Es; Maaike van den Born; Carla Kroon-Veenboer; Nick Barker; Allon M Klein; Jacco van Rheenen; Benjamin D Simons; Hans Clevers
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
Cell 2010;143(1):134-44.
2010: Robert G J Vries; Meritxell Huch; Hans Clevers
Stem cells and cancer of the stomach and intestine.
Molecular oncology 2010;4(5):373-84.
2010: Cynthia Kosinski; Daniel E Stange; Chuanrui Xu; Annie Sy Chan; Coral Ho; Siu Tsan Yuen; Randy C Mifflin; Don W Powell; Hans Clevers; Suet Yi Leung; Xin Chen
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.
Gastroenterology 2010;139(3):893-903.
2010: Martinus I F J Oerlemans; Marie-José Goumans; Ben van Middelaar; Hans Clevers; Pieter A Doevendans; Joost P G Sluijter
Active Wnt signaling in response to cardiac injury.
Basic research in cardiology 2010;105(5):631-41.
2010: Michael P Verzi; Pantelis Hatzis; Rita Sulahian; Juliet Philips; Jurian Schuijers; Hyunjin Shin; Ellen Freed; John P Lynch; Duyen T Dang; Myles Brown; Hans Clevers; X Shirley Liu; Ramesh A Shivdasani
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15157-62.
2010: Gabrielle H Ashton; Jennifer P Morton; Kevin Myant; Toby J Phesse; Rachel A Ridgway; Victoria Marsh; Julie A Wilkins; Dimitris Athineos; Vanesa Muncan; Richard Kemp; Kristi Neufeld; Hans Clevers; Valerie G Brunton; Douglas J Winton; Xiaoyan Wang; Rosalie C Pelz; Alan R Clarke; Margaret C Frame; Owen J Sansom
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Developmental cell 2010;19(2):259-69.
2010: Esther M Verheyen; Hans Clevers
Wnts as self-renewal factors: mammary stem cells and beyond.
Cell stem cell 2010;6(6):494-5.
2010: Nick Barker; Hans Clevers
Lineage tracing in the intestinal epithelium.
Current protocols in stem cell biology 2010;Chapter 5():Unit5A.4.
2010: Nick Barker; Hans Clevers
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.
Gastroenterology 2010;138(5):1681-96.
2010: Antoinette Hollestelle; Jord H A Nagel; Marcel Smid; Suzanne Lam; Fons Elstrodt; Marijke Wasielewski; Ser Sue Ng; Pim J French; Justine K Peeters; Marieke J Rozendaal; Muhammad Riaz; Daphne G Koopman; Timo L M ten Hagen; Bertie H C G M de Leeuw; Ellen C Zwarthoff; Amina Teunisse; Peter van der Spek; Jan G M Klijn; Winand N M Dinjens; Stephen Ethier; Hans Clevers; Aart G Jochemsen; Michael A Den Bakker; John A Foekens; John Martens; Mieke Schutte
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast cancer research and treatment 2010;121(1):53-64.
2010: Daniele V F Tauriello; Andrea Haegebarth; Ineke Kuper; Mariola J Edelmann; Marre Henraat; Marijke R Canninga-Van Dijk; Benedikt M Kessler; Hans Clevers; Madelon M Maurice
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Molecular cell 2010;37(5):607-19.
2010: Hugo J Snippert; Andrea Haegebarth; Maria Kasper; Viljar Jaks; Johan H van Es; Nick Barker; Marc van de Wetering; Maaike van den Born; Harry Begthel; Robert G Vries; Daniel E Stange; Rune Toftgård; Hans Clevers
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Science (New York, N.Y.) 2010;327(5971):1385-9.
2010: Aaron J Quyn; Paul L Appleton; Francis A Carey; Robert J C Steele; Nick Barker; Hans Clevers; Rachel A Ridgway; Owen J Sansom; Inke S Näthke
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.
Cell stem cell 2010;6(2):175-81.
2010: Ser Sue Ng; Tokameh Mahmoudi; Vivian S W Li; Pantelis Hatzis; Paul J Boersema; shabaz mohammed; Albert J Heck; Hans Clevers
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.
Biological chemistry 2010;391(2-3):171-80.
2010: Linheng Li; Hans Clevers
Coexistence of quiescent and active adult stem cells in mammals.
Science (New York, N.Y.) 2010;327(5965):542-5.
2010: Nick Barker; Meritxell Huch; Pekka Kujala; Marc van de Wetering; Hugo J Snippert; Johan H van Es; Toshiro Sato; Daniel E Stange; Harry Begthel; Maaike van den Born; Esther Danenberg; Stieneke van den Brink; Jeroen Korving; Arie Abo; Peter J Peters; Nick Wright; Richard Poulsom; Hans Clevers
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Cell stem cell 2010;6(1):25-36.
2010: Michal Mokry; Pantelis Hatzis; Ewart de Bruijn; Jan Koster; Rogier Versteeg; Jurian Schuijers; Marc van de Wetering; Victor Guryev; Hans Clevers; Edwin Cuppen
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.
PloS one 2010;5(11):e15092.
2010: Tokameh Mahmoudi; Sylvia F Boj; Pantelis Hatzis; Vivian S W Li; Nadia Taouatas; Robert G J Vries; Hans Teunissen; Harry Begthel; Jeroen Korving; shabaz mohammed; Albert J R Heck; Hans Clevers
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
PLoS biology 2010;8(11):e1000539.
2010: Johan H van Es; Natalie de Geest; Maaike van de Born; Hans Clevers; Bassem A Hassan
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.
Nature communications 2010;1():18.
2010: Vivianda Menke; Johan H van Es; Wim de Lau; Maaike van den Born; Ernst J Kuipers; Peter D Siersema; Ron W F de Bruin; Johannes G Kusters; Hans Clevers
Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.
Disease models & mechanisms 2010;3(1-2):104-10.
2010: Alex Gregorieff; Hans Clevers
In situ hybridization to identify gut stem cells.
Current protocols in stem cell biology 2010;Chapter 2():Unit 2F.1.
2009: Ser Sue Ng; Tokameh Mahmoudi; Esther Danenberg; Inés Bejaoui; Wim de Lau; Hendrik C Korswagen; Mieke Schutte; Hans Clevers
Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade.
The Journal of biological chemistry 2009;284(51):35308-13.
2009: Ana Faro; Sylvia F Boj; Hans Clevers
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish.
Zebrafish 2009;6(4):361-76.
2009: Tokameh Mahmoudi; Vivian S W Li; Ser Sue Ng; Nadia Taouatas; Robert G J Vries; shabaz mohammed; Albert J Heck; Hans Clevers
The kinase TNIK is an essential activator of Wnt target genes.
The EMBO journal 2009;28(21):3329-40.
2009: Hans Clevers
Eyeing up new Wnt pathway players.
Cell 2009;139(2):227-9.
2009: Gang Chen; Thomas R Korfhagen; Yan Xu; Joseph Kitzmiller; Susan E Wert; Yutaka Maeda; Alexander Gregorieff; Hans Clevers; Jeffrey A Whitsett
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
The Journal of clinical investigation 2009;119(10):2914-24.
2009: Yvonne Begus-Nahrmann; André Lechel; Anna C Obenauf; Kodandaramireddy Nalapareddy; Elvira Peit; Eva Hoffmann; Falk Schlaudraff; Birgit Liss; Peter Schirmacher; Hans A Kestler; Esther Danenberg; Nick Barker; Hans Clevers; Michael R Speicher; K Lenhard Rudolph
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
Nature genetics 2009;41(10):1138-43.
2009: Alex Gregorieff; Daniel E Stange; Pekka Kujala; Harry Begthel; Maaike van den Born; Jeroen Korving; Peter J Peters; Hans Clevers
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gastroenterology 2009;137(4):1333-45.e1-3.
2009: Hui Fu; Jun Cai; Hans Clevers; Eva Fast; Susan Gray; Rachel Greenberg; Mukesh K Jain; Qiufu Ma; Mengsheng Qiu; David H Rowitch; Christopher M Taylor; Charles D Stiles
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11399-408.
2009: Hans Clevers
Searching for adult stem cells in the intestine.
EMBO molecular medicine 2009;1(5):255-9.
2009: Marnix Jansen; Jean Paul ten Klooster; G Johan A Offerhaus; Hans Clevers
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
Physiological reviews 2009;89(3):777-98.
2009: Feng Ye; Ying Chen; ThaoNguyen Hoang; Rusty L Montgomery; Xian-hui Zhao; Hong Bu; Tom Hu; Makoto M Taketo; Johan H van Es; Hans Clevers; Jenny Hsieh; Rhonda Bassel-Duby; Eric N Olson; Q Richard Lu
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Nature neuroscience 2009;12(7):829-38.
2009: Laurens G van der Flier; Andrea Haegebarth; Daniel E Stange; Marc van de Wetering; Hans Clevers
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
Gastroenterology 2009;137(1):15-7.
2009: Hugo J Snippert; Johan H van Es; Maaike van den Born; Harry Begthel; Daniel E Stange; Nick Barker; Hans Clevers
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Gastroenterology 2009;136(7):2187-2194.e1.
2009: Toshiro Sato; Robert G Vries; Hugo J Snippert; Marc van de Wetering; Nick Barker; Daniel E Stange; Johan H van Es; Arie Abo; Pekka Kujala; Peter J Peters; Hans Clevers
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature 2009;459(7244):262-5.
2009: Jean Paul ten Klooster; Marnix Jansen; Jin Yuan; Viola Oorschot; Harry Begthel; Valeria Di Giacomo; Frédéric Colland; John de Koning; Madelon M Maurice; Peter Hornbeck; Hans Clevers
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
Developmental cell 2009;16(4):551-62.
2009: Laurens G van der Flier; Marielle E van Gijn; Pantelis Hatzis; Pekka Kujala; Andrea Haegebarth; Daniel E Stange; Harry Begthel; Maaike van den Born; Victor Guryev; Irma Oving; Johan H van Es; Nick Barker; Peter J Peters; Marc van de Wetering; Hans Clevers
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell 2009;136(5):903-12.
2009: Ana Faro; Sylvia F Boj; Raquel Ambrósio; Olaf van den Broek; Jeroen Korving; Hans Clevers
T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.
Zebrafish 2009;6(1):59-68.
2009: Andrea Haegebarth; Hans Clevers
Wnt signaling, lgr5, and stem cells in the intestine and skin.
The American journal of pathology 2009;174(3):715-21.
2009: Hans Clevers
Inflammatory bowel disease, stress, and the endoplasmic reticulum.
The New England journal of medicine 2009;360(7):726-7.
2009: Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2009: Laurens G van der Flier; Hans Clevers
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
Annual review of physiology 2009;71():241-60.
2008: G Johan A Offerhaus; A N A Milne; I M Oving; M E van Gijn; Ralph Hruban; Hans Clevers
A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling.
Gut 2008;57(12):1739-40.
2008: Viljar Jaks; Nick Barker; Maria Kasper; Johan H van Es; Hugo J Snippert; Hans Clevers; Rune Toftgård
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Nature genetics 2008;40(11):1291-9.
2008: Wolfram Goessling; Trista E North; Allegra M Lord; Craig Ceol; Sang Lee; Gilbert Weidinger; Caitlin Bourque; Robbert Strijbosch; Anna-Pavlina Haramis; Mark Puder; Hans Clevers; Randall T Moon; Leonard I Zon
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.
Developmental biology 2008;320(1):161-74.
2008: Nick Barker; Marc van de Wetering; Hans Clevers
The intestinal stem cell.
Genes & development 2008;22(14):1856-64.
2008: Carole J Burns; Jianmin Zhang; Erinn C Brown; Alyssa M Van Bibber; Johan Van Es; Hans Clevers; Tomo-O Ishikawa; M Mark Taketo; Monica L Vetter; Sabine Fuhrmann
Investigation of Frizzled-5 during embryonic neural development in mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(6):1614-26.
2008: Orbicia Riccio; Marielle E van Gijn; April C Bezdek; Luca Pellegrinet; Johan H van Es; Ursula Zimber-Strobl; Lothar Strobl; Tasuku Honjo; Hans Clevers; Freddy Radtke
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
EMBO reports 2008;9(4):377-83.
2008: Pantelis Hatzis; Laurens G van der Flier; Marc A van Driel; Victor Guryev; Fiona Nielsen; Sergei Denissov; Isaäc J Nijman; Jan Koster; Evan E Santo; Willem Welboren; Rogier Versteeg; Edwin Cuppen; Marc van de Wetering; Hans Clevers; Hendrik G Stunnenberg
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
Molecular and cellular biology 2008;28(8):2732-44.
2008: Nick Barker; Johan H van Es; V Jaks; M Kasper; H Snippert; R Toftgård; Hans Clevers
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():351-6.
2007: Jacob Sabates Bellver; Laurens G Van der Flier; Mariagrazia De Palo; Elisa Cattaneo; Caroline Maake; Hubert Rehrauer; Endre Laczko; Michal A Kurowski; Janusz Bujnicki; Mirco Menigatti; Judith Luz; Teresa V Ranalli; Vito Gomes; Alfredo Pastorelli; Roberto Faggiani; Marcello Anti; Josef Jiricny; Hans Clevers; Giancarlo Marra
Transcriptome profile of human colorectal adenomas.
Molecular cancer research : MCR 2007;5(12):1263-75.
2007: Nick Barker; Hans Clevers
Tracking down the stem cells of the intestine: strategies to identify adult stem cells.
Gastroenterology 2007;133(6):1755-60.
2007: Benedikt M Kessler; Elisabetta Fortunati; Monique Melis; Cornelieke E G M Pals; Hans Clevers; Madelon M Maurice
Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.
Journal of proteome research 2007;6(11):4163-72.
2007: Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Nature 2007;449(7165):1003-7.
2007: Mascha van Noort; Floor Weerkamp; Hans Clevers; Frank Staal
Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools.
Blood 2007;110(7):2778-9.
2007: Vanesa Muncan; Ana Faro; Anna-Pavlina G Haramis; Adam F L Hurlstone; Erno Wienholds; Johan H van Es; Jeroen Korving; Harry Begthel; Danica Zivkovic; Hans Clevers
T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.
EMBO reports 2007;8(10):966-73.
2007: Alex Gregorieff; Hans Clevers
Giving APCmin tumours a SPARC.
Gut 2007;56(10):1341-3.
2007: Jan Wehkamp; Guoxing Wang; Irmgard Kübler; Sabine Nuding; Alex Gregorieff; Anke Schnabel; Robert J Kays; Klaus Fellermann; Oliver Burk; Matthias Schwab; Hans Clevers; Charles L Bevins; Eduard F Stange
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3109-18.
2007: Samantha A Brugmann; L Henry Goodnough; Alex Gregorieff; Philipp Leucht; Derk ten Berge; Christophe Fuerer; Hans Clevers; Roel Nusse; Jill A Helms
Wnt signaling mediates regional specification in the vertebrate face.
Development (Cambridge, England) 2007;134(18):3283-95.
2007: Yasushi Kojima; Hiroyuki Miyoshi; Hans Clevers; Masanobu Oshima; Masahiro Aoki; Makoto M Taketo
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
The Journal of biological chemistry 2007;282(32):23532-40.
2007: Yuko Mori-Akiyama; Maaike van den Born; Johan H van Es; Stanley R Hamilton; Henry P Adams; Jiexin Zhang; Hans Clevers; Benoit de Crombrugghe
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.
Gastroenterology 2007;133(2):539-46.
2007: Owen J Sansom; Valerie Meniel; Vanesa Muncan; Toby J Phesse; Julie A Wilkins; Karen R Reed; J Keith Vass; Dimitris Athineos; Hans Clevers; Alan R Clarke
Myc deletion rescues Apc deficiency in the small intestine.
Nature 2007;446(7136):676-9.
2007: Jordane Malaterre; Marina R Carpinelli; Matthias Ernst; Warren Alexander; Michael Cooke; Susan Sutton; Sebastian Dworkin; Joan K Heath; Jon Frampton; Grant A McArthur; Hans Clevers; Douglas Hilton; Theo Mantamadiotis; Robert G Ramsay
c-Myb is required for progenitor cell homeostasis in colonic crypts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3829-34.
2007: Laurens G Van der Flier; Jacob Sabates Bellver; Irma Oving; Andrea Haegebarth; Mariagrazia De Palo; Marcello Anti; Marielle E van Gijn; Saskia Suijkerbuijk; Marc van de Wetering; Giancarlo Marra; Hans Clevers
The Intestinal Wnt/TCF Signature.
Gastroenterology 2007;132(2):628-32.
2007: Marc Vooijs; Chin-Tong Ong; Brandon K Hadland; Stacey S Huppert; Zhenyi Liu; Jeroen Korving; Maaike van den Born; Thaddeus S Stappenbeck; Yumei Wu; Hans Clevers; Raphael Kopan
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
Development (Cambridge, England) 2007;134(3):535-44.
2007: Wim de Lau; Nick Barker; Hans Clevers
WNT signaling in the normal intestine and colorectal cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():471-91.
2006: Nick Barker; Hans Clevers
Mining the Wnt pathway for cancer therapeutics.
Nature reviews. Drug discovery 2006;5(12):997-1014.
2006: Hans Clevers
Wnt/beta-catenin signaling in development and disease.
Cell 2006;127(3):469-80.
2006: Vanesa Muncan; Owen J Sansom; Leon Tertoolen; Toby J Phesse; Harry Begthel; Elena Sancho; Alicia M Cole; Alex Gregorieff; Ignacio Moreno de Alboran; Hans Clevers; Alan R Clarke
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Molecular and cellular biology 2006;26(22):8418-26.
2006: Ewa Markiewicz; Katarzyna Tilgner; Nick Barker; Mark van de Wetering; Hans Clevers; Malgorzata Dorobek; Irena Hausmanowa-Petrusewicz; Frans C S Ramaekers; Jos L V Broers; W Matthijs Blankesteijn; Georgia Salpingidou; Robert G Wilson; Juliet A Ellis; Christopher J Hutchison
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
The EMBO journal 2006;25(14):3275-85.
2006: Andrea Thiele; Yoshikuni Nagamine; Sunna Hauschildt; Hans Clevers
AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability.
Experimental cell research 2006;312(12):2367-78.
2006: Rachel H Giles; Martijn Lolkema; Cristel M J T Snijckers; M Belderbos; Petra van Der Groep; Dorus A Mans; Moniek van Beest; Mascha van Noort; roel goldschmeding; Paulus van Diest; Hans Clevers; Emile E Voest
Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis.
Oncogene 2006;25(21):3065-70.
2006: Freddy Radtke; Hans Clevers; Orbicia Riccio
From gut homeostasis to cancer.
Current molecular medicine 2006;6(3):275-89.
2006: Zhaofeng Huang; Huimin Xie; Vassilios Ioannidis; Werner Held; Hans Clevers; Maureen S Sadim; Zuoming Sun
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4880-7.
2006: Anna-Pavlina G Haramis; Adam F L Hurlstone; Yme van der Velden; Harry Begthel; Maaike van den Born; G Johan A Offerhaus; Hans Clevers
Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.
EMBO reports 2006;7(4):444-9.
2006: Hans Clevers
Colon cancer--understanding how NSAIDs work.
The New England journal of medicine 2006;354(7):761-3.
2006: Frank C P Holstege; Hans Clevers
Transcription factor target practice.
Cell 2006;124(1):21-3.
2006: Angeliki Malliri; Tomasz P Rygiel; Rob A van der Kammen; Ji-Ying Song; Rainer Engers; Adam F L Hurlstone; Hans Clevers; John G Collard
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
The Journal of biological chemistry 2006;281(1):543-8.
2006: Hans Clevers; Eduard Batlle
EphB/EphrinB receptors and Wnt signaling in colorectal cancer.
Cancer research 2006;66(1):2-5.
2005: Maria E Wilson; Katherine Y Yang; Anna Kalousova; Janet Lau; Yasuhiro Kosaka; Francis C Lynn; Juehu Wang; Caroline Mrejen; Vasso Episkopou; Hans Clevers; Michael S German
The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
Diabetes 2005;54(12):3402-9.
2005: Johan H van Es; Hans Clevers
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.
Trends in molecular medicine 2005;11(11):496-502.
2005: Hans Clevers
Stem cells, asymmetric division and cancer.
Nature genetics 2005;37(10):1027-8.
2005: Owen J Sansom; Karen R Reed; Marc van de Wetering; Vanesa Muncan; Douglas J Winton; Hans Clevers; Alan R Clarke
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.
The Journal of biological chemistry 2005;280(31):28463-7.
2005: Alex Gregorieff; Daniel Pinto; Harry Begthel; Olivier Destrée; Menno Kielman; Hans Clevers
Expression pattern of Wnt signaling components in the adult intestine.
Gastroenterology 2005;129(2):626-38.
2005: Jurgen Riedl; Dominique T Brandt; Eduard Batlle; Leo S Price; Hans Clevers; Johannes L Bos
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.
The Biochemical journal 2005;389(Pt 2):465-9.
2005: Eduard Batlle; Julinor Bacani; Harry Begthel; Suzanne Jonkheer; Suzanne Jonkeer; Alex Gregorieff; Maaike van de Born; Núria Malats; Elena Sancho; Elles Boon; Tony Pawson; Steven Gallinger; Steven T Pals; Hans Clevers
EphB receptor activity suppresses colorectal cancer progression.
Nature 2005;435(7045):1126-30.
2005: Johan H van Es; Marielle E van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J Winton; Freddy Radtke; Hans Clevers
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Nature 2005;435(7044):959-63.
2005: Daniel Pinto; Hans Clevers
Wnt control of stem cells and differentiation in the intestinal epithelium.
Experimental cell research 2005;306(2):357-63.
2005: Christelle Forcet; Sandrine Etienne-Manneville; Hélène Gaude; Laurence Fournier; Sébastien Debilly; Marko Salmi; Annette Baas; Sylviane Olschwang; Hans Clevers; Marc Billaud
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
Human molecular genetics 2005;14(10):1283-92.
2005: Donald A Glass; Peter Bialek; Jong Deok Ahn; Michael Starbuck; Millan S Patel; Hans Clevers; Mark M Taketo; Fanxin Long; Andrew P McMahon; Richard Lang; Gerard Karsenty
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Developmental cell 2005;8(5):751-64.
2005: Alex Gregorieff; Hans Clevers
Wnt signaling in the intestinal epithelium: from endoderm to cancer.
Genes & development 2005;19(8):877-90.
2005: Tannishtha Reya; Hans Clevers
Wnt signalling in stem cells and cancer.
Nature 2005;434(7035):843-50.
2005: Johan H van Es; Philippe Jay; Alex Gregorieff; Marielle E van Gijn; Suzanne Jonkheer; Pantelis Hatzis; Andrea Thiele; Maaike van den Born; Harry Begthel; Thomas Brabletz; Makoto M Taketo; Hans Clevers
Wnt signalling induces maturation of Paneth cells in intestinal crypts.
Nature cell biology 2005;7(4):381-6.
2005: Freddy Radtke; Hans Clevers
Self-renewal and cancer of the gut: two sides of a coin.
Science (New York, N.Y.) 2005;307(5717):1904-9.
2005: Daniel Pinto; Hans Clevers
Wnt, stem cells and cancer in the intestine.
Biology of the cell / under the auspices of the European Cell Biology Organization 2005;97(3):185-96.
2005: Jamila Laoukili; Matthijs R H Kooistra; Alexandra Brás; Jos J W Kauw; Ron Kerkhoven; Ashby Morrison; Hans Clevers; René H Medema
FoxM1 is required for execution of the mitotic programme and chromosome stability.
Nature cell biology 2005;7(2):126-36.
2005: Frank Staal; Hans Clevers
WNT signalling and haematopoiesis: a WNT-WNT situation.
Nature reviews. Immunology 2005;5(1):21-30.
2004: Hans Clevers
At the crossroads of inflammation and cancer.
Cell 2004;118(6):671-4.
2004: Hans Clevers
Signaling mucins in the (S)limelight.
Developmental cell 2004;7(2):150-1.
2004: Gienke R Boersma-Vreugdenhil; Jeroen Kuipers; Esther Van Stralen; Ton Peeters; Lucienne Michaux; Anne Hagemeijer; Peter L Pearson; Hans Clevers; bert bast
The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint.
British journal of haematology 2004;126(3):355-63.
2004: philippe blache; Marc van de Wetering; Isabelle Duluc; Claire Domon; Philippe Berta; Jean-Noel Freund; Hans Clevers; Philippe Jay
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.
The Journal of cell biology 2004;166(1):37-47.
2004: Ngoc Hang Le; Paola van der Bent - Klootwijk; Gerwin Huls; Marc van de Wetering; Mahmoud Loghman-Adham; Albert C M Ong; James P Calvet; Hans Clevers; Martijn H Breuning; Hans van Dam; Dorien J M Peters
Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected.
The Journal of biological chemistry 2004;279(26):27472-81.
2004: Owen J Sansom; Karen R Reed; Anthony J Hayes; Heather Ireland; Hannah Brinkmann; Ian P Newton; Eduard Batlle; Patricia Simon-Assmann; Hans Clevers; Inke S Nathke; Alan R Clarke; Douglas J Winton
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Genes & development 2004;18(12):1385-90.
2004: Hans Clevers
Wnt signaling: Ig-norrin the dogma.
Current biology : CB 2004;14(11):R436-7.
2004: Annette F Baas; Linda Smit; Hans Clevers
LKB1 tumor suppressor protein: PARtaker in cell polarity.
Trends in cell biology 2004;14(6):312-9.
2004: Linda Smit; Annette F Baas; Jeroen Kuipers; Hendrik Korswagen; Marc van de Wetering; Hans Clevers
Wnt activates the Tak1/Nemo-like kinase pathway.
The Journal of biological chemistry 2004;279(17):17232-40.
2004: Alex Gregorieff; Rudolf Grosschedl; Hans Clevers
Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.
The EMBO journal 2004;23(8):1825-33.
2004: Patrick W B Derksen; Esther P M Tjin; Helen P Meijer; Melanie D Klok; Harold D MacGillavry; Marinus H J van Oers; Henk M Lokhorst; Andries C Bloem; Hans Clevers; Roel Nusse; Ronald van der Neut; Marcel Spaargaren; Steven T Pals
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6122-7.
2004: Anna-Pavlina G Haramis; Harry Begthel; Maaike van den Born; Johan H van Es; Suzanne Jonkheer; G Johan A Offerhaus; Hans Clevers
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.
Science (New York, N.Y.) 2004;303(5664):1684-6.
2004: Annette F Baas; Jeroen Kuipers; Nicole N Van Der Wel; Eduard Batlle; Henk K Koerten; Peter J Peters; Hans Clevers
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.
Cell 2004;116(3):457-66.
2004: Elena Sancho; Eduard Batlle; Hans Clevers
Signaling pathways in intestinal development and cancer.
Annual review of cell and developmental biology 2004;20():695-723.
2004: Hans Clevers
Wnt breakers in colon cancer.
Cancer cell 2004;5(1):5-6.
2003: Elena Sancho; Eduard Batlle; Hans Clevers
Live and let die in the intestinal epithelium.
Current opinion in cell biology 2003;15(6):763-70.
2003: Markus Morkel; Joerg Huelsken; Maki Wakamiya; Jixiang Ding; Marc van de Wetering; Hans Clevers; Makoto M Taketo; Richard R Behringer; Michael M Shen; Walter Birchmeier
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Development (Cambridge, England) 2003;130(25):6283-94.
2003: Annelies Verbrugge; Talitha de Ruiter Td; Hans Clevers; Linde Meyaard
Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.
International immunology 2003;15(11):1349-58.
2003: Michelle L Brinkmeier; Mary Anne Potok; Kelly B Cha; Thomas Gridley; Stefano Stifani; Jan Meeldijk; Hans Clevers; Sally A Camper
TCF and Groucho-related genes influence pituitary growth and development.
Molecular endocrinology (Baltimore, Md.) 2003;17(11):2152-61.
2003: Adam F L Hurlstone; Anna-Pavlina G Haramis; Erno Wienholds; Harry Begthel; Jeroen Korving; Fredericus J M van Eeden; Edwin Cuppen; Danica Zivkovic; Ronald H Plasterk; Hans Clevers
The Wnt/beta-catenin pathway regulates cardiac valve formation.
Nature 2003;425(6958):633-7.
2003: Linde Meyaard; AR van der Vuurst de Vries; Talitha Eshuis - de Ruiter; Lewis L Lanier; Joseph H Phillips; Hans Clevers
Retraction.
The Journal of experimental medicine 2003;198(7):1129.
2003: Jérôme Boudeau; Annette F Baas; Maria Deak; Nick A Morrice; Agnieszka Kieloch; Mike Schutkowski; Alan R Prescott; Hans Clevers; Dario R Alessi
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
The EMBO journal 2003;22(19):5102-14.
2003: Hans Clevers
Thymocyte development: drama without Brahma.
Immunity 2003;19(2):157-8.
2003: Paul J Kim; Janet Plescia; Hans Clevers; Eric R Fearon; Dario C Altieri
Survivin and molecular pathogenesis of colorectal cancer.
Lancet 2003;362(9379):205-9.
2003: Daniel Pinto; Alex Gregorieff; Harry Begthel; Hans Clevers
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.
Genes & development 2003;17(14):1709-13.
2003: Annette F Baas; Jérôme Boudeau; Gopal P Sapkota; Linda Smit; R Medema; Nick A Morrice; Dario R Alessi; Hans Clevers
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
The EMBO journal 2003;22(12):3062-72.
2003: Rachel H Giles; Johan H van Es; Hans Clevers
Caught up in a Wnt storm: Wnt signaling in cancer.
Biochimica et biophysica acta 2003;1653(1):1-24.
2003: Marc van de Wetering; Irma Oving; Vanesa Muncan; Menno Tjon Pon Fong; Helen Brantjes; Dik van Leenen; Frank C P Holstege; Thijn R Brummelkamp; Reuven Agami; Hans Clevers
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
EMBO reports 2003;4(6):609-15.
2003: Werner Held; Hans Clevers; Rudolf Grosschedl
Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition.
European journal of immunology 2003;33(5):1393-8.
2003: Frank Staal; Hans Clevers
Wnt signaling in the thymus.
Current opinion in immunology 2003;15(2):204-8.
2003: Mariann Bienz; Hans Clevers
Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?
Nature cell biology 2003;5(3):179-82.
2003: Michael Nicolas; Anita Wolfer; Kenneth Raj; J Alain Kummer; Pleasantine Mill; Mascha van Noort; Chi-Chung Hui; Hans Clevers; G Paolo Dotto; Freddy Radtke
Notch1 functions as a tumor suppressor in mouse skin.
Nature genetics 2003;33(3):416-21.
2003: Johan H van Es; Nick Barker; Hans Clevers
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.
Current opinion in genetics & development 2003;13(1):28-33.
2002: Hans Clevers
Inflating cell numbers by Wnt.
Molecular cell 2002;10(6):1260-1.
2002: Eduard Batlle; Dr. Jeffrey Henderson; Harry Beghtel; Maaike van den Born; Elena Sancho; Gerwin Huls; Jan Meeldijk; Jennifer Robertson; Marc van de Wetering; Tony Pawson; Hans Clevers
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Cell 2002;111(2):251-63.
2002: Marc van de Wetering; Elena Sancho; Cornelis Verweij; Wim de Lau; Irma Oving; Adam F L Hurlstone; Karin van der Horn; Eduard Batlle; Damien Y M Coudreuse; Anna-Pavlina G Haramis; Menno Tjon-Pon-Fong; Petra Moerer; Maaike van den Born; Gwen Soete; Steven T Pals; Martin Eilers; Rene Medema; Hans Clevers
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Cell 2002;111(2):241-50.
2002: Ronald C J Gallagher; Trevor Hay; Valerie Meniel; Catherine Naughton; Thomas J Anderson; Hiroyuki Shibata; Masaki Ito; Hans Clevers; Tetsuo Noda; Owen J Sansom; John O Mason; Alan R Clarke
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.
Oncogene 2002;21(42):6446-57.
2002: Elles M J Boon; Ronald van der Neut; Marc van de Wetering; Hans Clevers; Steven T Pals
Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer.
Cancer research 2002;62(18):5126-8.
2002: Mascha van Noort; Marc van de Wetering; Hans Clevers
Identification of two novel regulated serines in the N terminus of beta-catenin.
Experimental cell research 2002;276(2):264-72.
2002: Irma M Oving; Hans Clevers
Molecular causes of colon cancer.
European journal of clinical investigation 2002;32(6):448-57.
2002: Mascha van Noort; Jan Meeldijk; Ruurd van der Zee; Olivier Destree; Hans Clevers
Wnt signaling controls the phosphorylation status of beta-catenin.
The Journal of biological chemistry 2002;277(20):17901-5.
2002: Hendrik C Korswagen; Damien Y M Coudreuse; Marco C Betist; Sandra van de Water; Danica Zivkovic; Hans Clevers
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
Genes & development 2002;16(10):1291-302.
2002: Adam F L Hurlstone; Hans Clevers
T-cell factors: turn-ons and turn-offs.
The EMBO journal 2002;21(10):2303-11.
2002: Adam F L Hurlstone; Ivan A Olave; Nick Barker; Mascha van Noort; Hans Clevers
Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.
The Biochemical journal 2002;364(Pt 1):255-64.
2002: Sophia S Cheon; Alexander Y L Cheah; Stefanie Turley; Puviindran Nadesan; Raymond Poon; Hans Clevers; Benjamin A Alman
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6973-8.
2002: Marc van de Wetering; Wim de Lau; Hans Clevers
WNT signaling and lymphocyte development.
Cell 2002;109 Suppl():S13-9.
2002: Mascha van Noort; Hans Clevers
TCF transcription factors, mediators of Wnt-signaling in development and cancer.
Developmental biology 2002;244(1):1-8.
2002: Helen Brantjes; Nick Barker; Johan H van Es; Hans Clevers
TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.
Biological chemistry 2002;383(2):255-61.
2002: Barbara Lustig; Boris Jerchow; Martin Sachs; Sigrid Weiler; Torsten Pietsch; Uwe Karsten; Marc van de Wetering; Hans Clevers; Peter M Schlag; Walter Birchmeier; Jürgen Behrens
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Molecular and cellular biology 2002;22(4):1184-93.
2002: Frank Staal; Mascha van Noort Mv; Ger J Strous; Hans Clevers
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
EMBO reports 2002;3(1):63-8.
2001: Riccardo Fodde; Ron Smits; Hans Clevers
APC, signal transduction and genetic instability in colorectal cancer.
Nature reviews. Cancer 2001;1(1):55-67.
2001: Sandra van de Water; M van de Wetering; Jos Joore; J Esseling; Robert J Bink; Hans Clevers; Danica Zivkovic
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.
Development (Cambridge, England) 2001;128(20):3877-88.
2001: Nick Barker; Adam F L Hurlstone; Hannah Musisi; A Miles; Mariann Bienz; Hans Clevers
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.
The EMBO journal 2001;20(17):4935-43.
2001: Vassilios Ioannidis; Friedrich Beermann; Hans Clevers; Werner Held
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
Nature immunology 2001;2(8):691-7.
2001: Linde Meyaard; AR van der Vuurst de Vries; Talitha Eshuis - de Ruiter; Lewis L Lanier; Joseph H Phillips; Hans Clevers
The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).
The Journal of experimental medicine 2001;194(1):107-12.
2001: Riccardo Fodde; J Kuipers; Carla Rosenberg; Ron Smits; Menno F Kielman; Claudia Gaspar; Johan H van Es; Cor Breukel; Joop Wiegant; Rachel H Giles; Hans Clevers
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Nature cell biology 2001;3(4):433-8.
2001: Helen Brantjes; J Roose; Marc van de Wetering; Hans Clevers
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
Nucleic acids research 2001;29(7):1410-9.
2001: Johan H van Es; Rachel H Giles; Hans Clevers
The many faces of the tumor suppressor gene APC.
Experimental cell research 2001;264(1):126-34.
2001: Frank Staal; Hans Clevers
Regulation of lineage commitment during lymphocyte development.
International reviews of immunology 2001;20(1):45-64.
2001: Frank Staal; Floor Weerkamp; Anton Langerak; Rudolf W Hendriks; Hans Clevers
Transcriptional control of t lymphocyte differentiation.
Stem cells (Dayton, Ohio) 2001;19(3):165-79.
2001: Frank Staal; Jan Meeldijk; Petra Moerer; P Jay; B C van de Weerdt; S Vainio; G P Nolan; Hans Clevers
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.
European journal of immunology 2001;31(1):285-93.
2001: Marc van de Wetering; Nick Barker; IC Harkes; Michiel van der Heyden; N J Dijk; Antoinette Hollestelle; Jan G M Klijn; Hans Clevers; Mieke Schutte
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
Cancer research 2001;61(1):278-84.
2000: Nick Barker; Hans Clevers
Catenins, Wnt signaling and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(11):961-5.
2000: Heiko Lickert; Claire Domon; G Huls; Christian Wehrle; Isabelle Duluc; Hans Clevers; B I Meyer; Jean-Noel Freund; Rolf Kemler
Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.
Development (Cambridge, England) 2000;127(17):3805-13.
2000: X Yang; Moniek van Beest; Hans Clevers; Tamara Jones; Deborah A Hursh; Mark A Mortin
decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm.
Development (Cambridge, England) 2000;127(17):3695-702.
2000: Moniek van Beest; Dennis Dooijes; Marc van de Wetering; Søren Kjaerulff; Alexandre Bonvin; Olaf Nielsen; Hans Clevers
Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.
The Journal of biological chemistry 2000;275(35):27266-73.
2000: Hendrik C Korswagen; M A Herman; Hans Clevers
Distinct beta-catenins mediate adhesion and signalling functions in C. elegans.
Nature 2000;406(6795):527-32.
2000: M Molenaar; E Brian; J Roose; Hans Clevers; Olivier Destrée
Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis.
Mechanisms of development 2000;91(1-2):311-5.
2000: Nick Barker; Patrice J Morin; Hans Clevers
The Yin-Yang of TCF/beta-catenin signaling.
Advances in cancer research 2000;77():1-24.
1999: J Roose; Hans Clevers
TCF transcription factors: molecular switches in carcinogenesis.
Biochimica et biophysica acta 1999;1424(2-3):M23-37.
1999: Werner Held; Béatrice Kunz; Bente Lowin-Kropf; M van de Wetering; Hans Clevers
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
Immunity 1999;11(4):433-42.
1999: AR van der Vuurst de Vries; Hans Clevers; Ton Logtenberg; Linde Meyaard
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.
European journal of immunology 1999;29(10):3160-7.
1999: J Roose; Gerwin Huls; Moniek van Beest; Petra Moerer; Karin van der Horn; roel goldschmeding; Ton Logtenberg; Hans Clevers
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science (New York, N.Y.) 1999;285(5435):1923-6.
1999: Linde Meyaard; J Hurenkamp; Hans Clevers; Lewis L Lanier; Joseph H Phillips
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5800-4.
1999: J Roose; W Korver; R de Boer; J Kuipers; J Hurenkamp; Hans Clevers
The Sox-13 gene: structure, promoter characterization, and chromosomal localization.
Genomics 1999;57(2):301-5.
1999: Frank Staal; Boudewijn M T Burgering; M van de Wetering; Hans Clevers
Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.
International immunology 1999;11(3):317-23.
1999: J Kuipers; J W Vaandrager; D O Weghuis; Peter L Pearson; J M J C Scheres; Henk M Lokhorst; Hans Clevers; bert bast
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
Cancer genetics and cytogenetics 1999;109(2):99-107.
1999: VJ Wielenga; Ron Smits; V Korinek; Laura A Smit; Menno F Kielman; Riccardo Fodde; Hans Clevers; Steven T Pals
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.
The American journal of pathology 1999;154(2):515-23.
1999: Johan H van Es; C Kirkpatrick; Marc van de Wetering; M Molenaar; A Miles; J Kuipers; Olivier Destrée; Mark Peifer; Hans Clevers
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Current biology : CB 1999;9(2):105-8.
1999: Hendrik C Korswagen; Hans Clevers
Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors.
Cold Spring Harbor symposia on quantitative biology 1999;64():141-7.
1999: Nick Barker; Gerwin Huls; V Korinek; Hans Clevers
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.
The American journal of pathology 1999;154(1):29-35.
1998: W Korver; Marco W Schilham; Petra Moerer; M J van den Hoff; K Dam; W H Lamers; R H Medema; Hans Clevers
Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident.
Current biology : CB 1998;8(24):1327-30.
1998: J Ya; M W Schilham; Piet A J de Boer; Antoon F M Moorman; Hans Clevers; Wouter H Lamers
Sox4-deficiency syndrome in mice is an animal model for common trunk.
Circulation research 1998;83(10):986-94.
1998: Marco W Schilham; A Wilson; Petra Moerer; B J Benaissa-Trouw; A Cumano; Hans Clevers
Critical involvement of Tcf-1 in expansion of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3984-91.
1998: J Roose; M Molenaar; J Peterson; J Hurenkamp; Helen Brantjes; Petra Moerer; Marc van de Wetering; Olivier Destrée; Hans Clevers
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.
Nature 1998;395(6702):608-12.
1998: R A Cavallo; RT Cox; MM Moline; J Roose; G A Polevoy; Hans Clevers; Mark Peifer; Amy Bejsovec
Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
Nature 1998;395(6702):604-8.
1998: Moniek van Beest; Mark A Mortin; Hans Clevers
Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF.
Nucleic acids research 1998;26(19):4471-5.
1998: V Korinek; Nick Barker; Petra Moerer; Elly van Donselaar; Gerwin Huls; Peter J Peters; Hans Clevers
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Nature genetics 1998;19(4):379-83.
1998: M Molenaar; J Roose; J Peterson; S Venanzi; Hans Clevers; Olivier Destrée
Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development.
Mechanisms of development 1998;75(1-2):151-4.
1998: Marco W Schilham; Hans Clevers
HMG box containing transcription factors in lymphocyte differentiation.
Seminars in immunology 1998;10(2):127-32.
1998: Dennis Dooijes; Moniek van Beest; Marc van de Wetering; G Boulanger; Tamara Jones; Hans Clevers; Mark A Mortin
Genomic organization of the segment polarity gene pan in Drosophila melanogaster.
Molecular & general genetics : MGG 1998;258(1-2):45-52.
1998: Hans Clevers; P Ferrier
Transcriptional control during T-cell development.
Current opinion in immunology 1998;10(2):166-71.
1998: V Korinek; Nick Barker; K Willert; M Molenaar; J Roose; G Wagenaar; M Markman; W Lamers; O Destree; Hans Clevers
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.
Molecular and cellular biology 1998;18(3):1248-56.
1998: W B de Lau; J Kuipers; Peter J Peters; Henk M Lokhorst; Hans Clevers; bert bast
Putative myeloma precursor cells expressing 2,6 sialic acid-modified antigens actually belong to the erythroid lineage.
Leukemia research 1998;22(2):163-73.
1998: J Roose; W Korver; E Oving; A Wilson; G Wagenaar; M Markman; W Lamers; Hans Clevers
High expression of the HMG box factor sox-13 in arterial walls during embryonic development.
Nucleic acids research 1998;26(2):469-76.
1997: W Korver; J Roose; K Heinen; D O Weghuis; Diederik R H de Bruijn; Ad Geurts van Kessel; Hans Clevers
The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.
Genomics 1997;46(3):435-42.
1997: W Korver; J Roose; A Wilson; Hans Clevers
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
Immunobiology 1997;198(1-3):157-61.
1997: Hans Clevers; Marc van de Wetering
TCF/LEF factor earn their wings.
Trends in genetics : TIG 1997;13(12):485-9.
1997: J Ya; M W Schilham; Hans Clevers; Antoon F M Moorman; Wouter H Lamers
Animal models of congenital defects in the ventriculoarterial connection of the heart.
Journal of molecular medicine (Berlin, Germany) 1997;75(8):551-66.
1997: Søren Kjaerulff; Dennis Dooijes; Hans Clevers; Olaf Nielsen
Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.
The EMBO journal 1997;16(13):4021-33.
1997: Dennis Dooijes; Hans Clevers
Control of gene expression during lymphoid development: targeted gene disruption provides new clues.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(5):337-44.
1997: Marco W Schilham; Petra Moerer; A Cumano; Hans Clevers
Sox-4 facilitates thymocyte differentiation.
European journal of immunology 1997;27(5):1292-5.
1997: W Korver; J Roose; Hans Clevers
The winged-helix transcription factor Trident is expressed in cycling cells.
Nucleic acids research 1997;25(9):1715-9.
1997: Marc van de Wetering; R Cavallo; Dennis Dooijes; Moniek van Beest; Johan H van Es; Joseph Loureiro; A Ypma; Deborah A Hursh; Tamara Jones; Amy Bejsovec; Mark Peifer; Mark A Mortin; Hans Clevers
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
Cell 1997;88(6):789-99.
1997: Patrice J Morin; Andrew B Sparks; V Korinek; Nick Barker; Hans Clevers; Bert Vogelstein; Kenneth W Kinzler
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Science (New York, N.Y.) 1997;275(5307):1787-90.
1997: V Korinek; Nick Barker; Patrice J Morin; D van Wichen; Roel A de Weger; Kenneth W Kinzler; Bert Vogelstein; Hans Clevers
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Science (New York, N.Y.) 1997;275(5307):1784-7.
1996: M Santos; Marco W Schilham; L H Rademakers; Joannes Marx; M de Sousa; Hans Clevers
Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.
The Journal of experimental medicine 1996;184(5):1975-85.
1996: Eefke J Petersen; Maja Rozenberg-Arska; Adriaan W Dekker; Hans Clevers; Leo F Verdonck
Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia.
Bone marrow transplantation 1996;18(4):813-5.
1996: M Molenaar; Marc van de Wetering; M Oosterwegel; J Peterson-Maduro; S Godsave; V Korinek; J Roose; Olivier Destrée; Hans Clevers
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
Cell 1996;86(3):391-9.
1996: Marco W Schilham; M A Oosterwegel; Petra Moerer; J Ya; Piet A J de Boer; Marc van de Wetering; S Verbeek; Wouter H Lamers; A M Kruisbeek; A Cumano; Hans Clevers
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4.
Nature 1996;380(6576):711-4.
1996: Marc van de Wetering; J Castrop; V Korinek; Hans Clevers
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.
Molecular and cellular biology 1996;16(3):745-52.
1996: T Ohteki; Anne Wilson; S Verbeek; H Robson MacDonald; Hans Clevers
Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice.
European journal of immunology 1996;26(2):351-5.
1995: L P van Houte; V P Chuprina; M van der Wetering; R Boelens; R Kaptein; Hans Clevers
Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4.
The Journal of biological chemistry 1995;270(51):30516-24.
1995: J Castrop; Dick F van Wichen; M Koomans-Bitter; Marc van de Wetering; Roel A de Weger; J van Dongen; Hans Clevers
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.
Blood 1995;86(8):3050-9.
1995: K Mayer; E Wolff; Hans Clevers; Wolfgang G Ballhausen
The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.
Biochimica et biophysica acta 1995;1263(2):169-72.
1995: P G Toye; M J Metzelaar; P L Wijngaard; Vishvanath Nene; K Iams; J Roose; J K Nyanjui; E Gobright; Anthony J Musoke; Hans Clevers
Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1370-81.
1995: J Castrop; S Verbeek; Frans M A Hofhuis; Hans Clevers
Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.
Immunobiology 1995;193(2-4):281-7.
1995: George L Scheffer; P L Wijngaard; Marcel J Flens; Miguel A Izquierdo; Marilyn L Slovak; HERBERT PINEDO; Chris J L M Meijer; Hans Clevers; Rik J Scheper
The drug resistance-related protein LRP is the human major vault protein.
Nature medicine 1995;1(6):578-82.
1995: S Verbeek; D Izon; Frans M A Hofhuis; Els C Robanus-Maandag; Hein te Riele; Marc van de Wetering; M Oosterwegel; Anne Wilson; H Robson MacDonald; Hans Clevers
An HMG-box-containing T-cell factor required for thymocyte differentiation.
Nature 1995;374(6517):70-4.
1994: ID Walker; MD Glew; Meredith O'Keeffe; S A Metcalfe; Hans Clevers; P L Wijngaard; Timothy E Adams; W R Hein
A novel multi-gene family of sheep gamma delta T cells.
Immunology 1994;83(4):517-23.
1994: P L Wijngaard; Niall D MacHugh; M J Metzelaar; S Romberg; Albert Bensaid; L Pepin; W C Davis; Hans Clevers
Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3476-82.
1993: Dennis Dooijes; Marc van de Wetering; L Knippels; Hans Clevers
The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.
The Journal of biological chemistry 1993;268(33):24813-7.
1993: Niall D MacHugh; P L Wijngaard; Hans Clevers; W C Davis
Clustering of monoclonal antibodies recognizing different members of the WC1 gene family.
Veterinary immunology and immunopathology 1993;39(1-3):155-60.
1993: Marc van de Wetering; M Oosterwegel; K van Norren; Hans Clevers
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.
The EMBO journal 1993;12(10):3847-54.
1993: M Oosterwegel; Marc van de Wetering; Hans Clevers
HMG box proteins in early T-cell differentiation.
Thymus 1993;22(2):67-81.
1993: L van Houte; A van Oers; Marc van de Wetering; Dennis Dooijes; R Kaptein; Hans Clevers
The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution.
The Journal of biological chemistry 1993;268(24):18083-7.
1993: W B De Lau; J Kuipers; H Voshol; Hans Clevers; bert bast
HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):4911-9.
1993: M Oosterwegel; Marc van de Wetering; J Timmerman; A Kruisbeek; O Destree; F Meijlink; Hans Clevers
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis.
Development (Cambridge, England) 1993;118(2):439-48.
1993: Marco W Schilham; M van Eijk; Marc van de Wetering; Hans Clevers
The murine Sox-4 protein is encoded on a single exon.
Nucleic acids research 1993;21(8):2009.
1993: Marc van de Wetering; Hans Clevers
Sox 15, a novel member of the murine Sox family of HMG box transcription factors.
Nucleic acids research 1993;21(7):1669.
1992: P L Wijngaard; M J Metzelaar; Niall D MacHugh; W I Morrison; Hans Clevers
Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3273-7.
1992: M J Metzelaar; Hans Clevers
Lysosomal membrane glycoproteins in platelets.
Thrombosis and haemostasis 1992;68(4):378-82.
1992: W B De Lau; S E Boom; K Heije; A W Griffioen; E Braakman; R L Bolhuis; W J Tax; Hans Clevers; bert bast
Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):1840-6.
1992: Marc van de Wetering; Hans Clevers
Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.
The EMBO journal 1992;11(8):3039-44.
1992: J Gastrop; R Hoevenagel; J R Young; Hans Clevers
A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF-1 expressed in chicken T cells.
European journal of immunology 1992;22(5):1327-30.
1992: Marc van de Wetering; M Oosterwegel; F Holstege; D Dooyes; R Suijkerbuijk; A Geurts van Kessel; Hans Clevers
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
The Journal of biological chemistry 1992;267(12):8530-6.
1992: J Castrop; K van Norren; Hans Clevers
A gene family of HMG-box transcription factors with homology to TCF-1.
Nucleic acids research 1992;20(3):611.
1992: Albert Bensaid; A Kaushal; J R Young; C L Baldwin; Hans Clevers; Alan J Teale
[Physical mapping of the major histocompatibility complex of cattle].
Annales de recherches vétérinaires. Annals of veterinary research 1992;23(3):256-8.
1992: M Oosterwegel; J Timmerman; J Leiden; Hans Clevers
Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis.
Developmental immunology 1992;3(1):1-11.
1991: E Horst; P L Wijngaard; M Metzelaar; bert bast; Hans Clevers
A method for cDNA cloning in COS cells irrespective of subcellular site of expression.
Nucleic acids research 1991;19(16):4556.
1991: M Oosterwegel; Marc van de Wetering; Dennis Dooijes; L Klomp; A Winoto; K Georgopoulos; F Meijlink; Hans Clevers
Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
The Journal of experimental medicine 1991;173(5):1133-42.
1991: M J Metzelaar; P L Wijngaard; Peter J Peters; Jan J Sixma; H Karel Nieuwenhuis; Hans Clevers
CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.
The Journal of biological chemistry 1991;266(5):3239-45.
1991: Albert Bensaid; A Kaushal; C L Baldwin; Hans Clevers; J R Young; Stephen J Kemp; Niall D MacHugh; P G Toye; Alan J Teale
Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage.
Immunogenetics 1991;33(4):247-54.
1991: Marc van de Wetering; M Oosterwegel; Dennis Dooijes; Hans Clevers
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.
The EMBO journal 1991;10(1):123-32.
1990: Hans Clevers; Niall D MacHugh; Albert Bensaid; S Dunlap; C L Baldwin; A Kaushal; K Iams; C J Howard; W I Morrison
Identification of a bovine surface antigen uniquely expressed on CD4-CD8- T cell receptor gamma/delta+ T lymphocytes.
European journal of immunology 1990;20(4):809-17.
1989: Hans Clevers; N Lonberg; S Dunlap; Elizabeth Lacy; Cox Terhorst
An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter.
The EMBO journal 1989;8(9):2527-35.
1989: Peter J Peters; Hans J Geuze; H A Van der Donk; Jan W Slot; J M Griffith; N J Stam; Hans Clevers; Jannie Borst
Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes.
European journal of immunology 1989;19(8):1469-75.
1988: Hans Clevers; S Dunlap; Haruo Saito; K Georgopoulos; T Wileman; Cox Terhorst
Characterization and expression of the murine CD3-epsilon gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8623-7.
1988: Hans Clevers; S Dunlap; Cox Terhorst
The transmembrane orientation of the epsilon chain of the TcR/CD3 complex.
European journal of immunology 1988;18(5):705-10.
1988: Hans Clevers; B Alarcon; T Wileman; Cox Terhorst
The T cell receptor/CD3 complex: a dynamic protein ensemble.
Annual review of immunology 1988;6():629-62.
1987: Haruo Saito; T Koyama; K Georgopoulos; Hans Clevers; W G Haser; T LeBien; Susumu Tonegawa; Cox Terhorst
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9131-4.
1987: D P Gold; Hans Clevers; B Alarcon; S Dunlap; J Novotny; A F Williams; Cox Terhorst
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7649-53.