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Guy Clifton

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Hypothermia, Induced

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TOP 3
Guy L Clifton; Christopher S Coffey; Sierra Fourwinds; Melisa L Frisby; Harvey S Levin; Kenneth R Smith; Alex B Valadka; Elisabeth A Wilde; David Zygun; Richard D Bucholz; David O Okonkwo
Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials.
Guy L Clifton; Alex B Valadka; David Zygun; Christopher S Coffey; Pamala Drever; Sierra Fourwinds; L Scott Janis; Elizabeth Wilde; Pauline Taylor; Kathy Harshman; Adam Conley; Ava Puccio; Harvey S Levin; Stephen R McCauley; Richard D Bucholz; Kenneth R Smith; John H Schmidt; James N Scott; Howard Yonas; David O Okonkwo
Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.
Georgene W Hergenroeder; Anthony N Moore; J Philip McCoy; Leigh Samsel; Norman H Ward; Guy L Clifton; Pramod K Dash
Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.

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All Publications

2012: Guy L Clifton; Christopher S Coffey; Sierra Fourwinds; Melisa L Frisby; Harvey S Levin; Kenneth R Smith; Alex B Valadka; Elisabeth A Wilde; David Zygun; Richard D Bucholz; David O Okonkwo
Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials.
Journal of neurosurgery 2012;117(4):714-20.
2011: Guy L Clifton; Alex B Valadka; David Zygun; Christopher S Coffey; Pamala Drever; Sierra Fourwinds; L Scott Janis; Elizabeth Wilde; Pauline Taylor; Kathy Harshman; Adam Conley; Ava Puccio; Harvey S Levin; Stephen R McCauley; Richard D Bucholz; Kenneth R Smith; John H Schmidt; James N Scott; Howard Yonas; David O Okonkwo
Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.
Lancet neurology 2011;10(2):131-9.
2010: Georgene W Hergenroeder; Anthony N Moore; J Philip McCoy; Leigh Samsel; Norman H Ward; Guy L Clifton; Pramod K Dash
Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
Journal of neuroinflammation 2010;7():19.
2009: Guy L Clifton; Pamala Drever; Alex Valadka; David Zygun; David Okonkwo
Multicenter trial of early hypothermia in severe brain injury.
Journal of neurotrauma 2009;26(3):393-7.
2008: Georgene Hergenroeder; John B Redell; Anthony N Moore; William P Dubinsky; Robert T Funk; John Crommett; Guy L Clifton; Robert Levine; Alex B Valadka; Pramod K Dash
Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure.
Journal of neurotrauma 2008;25(2):79-93.
2006: Nobuhide Kobori; Guy L Clifton; Pramod K Dash
Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction.
Journal of neurotrauma 2006;23(7):1094-102.
2005: Jing Zhao; Anthony N Moore; Guy L Clifton; Pramod K Dash
Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.
Journal of neuroscience research 2005;82(4):499-506.
2004: Pramod K Dash; Anthony N Moore; Melanie R Moody; Robyn Treadwell; Jodie L Felix; Guy L Clifton
Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in rats.
Journal of neurotrauma 2004;21(11):1573-83.
2004: Guy L Clifton
Is keeping cool still hot? An update on hypothermia in brain injury.
Current opinion in critical care 2004;10(2):116-9.
2004: Nobuhide Kobori; Jack C Waymire; John W Haycock; Guy L Clifton; Pramod K Dash
Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor.
The Journal of biological chemistry 2004;279(3):2182-91.
2002: Guy L Clifton; Paula Knudson; Marilyn McDonald
Waiver of consent in studies of acute brain injury.
Journal of neurotrauma 2002;19(10):1121-6.
2002: Nobuhide Kobori; Guy L Clifton; Pramod Dash
Altered expression of novel genes in the cerebral cortex following experimental brain injury.
Brain research. Molecular brain research 2002;104(2):148-58.
2002: Guy L Clifton; Emmy R Miller; Sung C Choi; Harvey S Levin
Fluid thresholds and outcome from severe brain injury.
Critical care medicine 2002;30(4):739-45.
2002: Guy L Clifton; Emmy R Miller; Sung C Choi; Harvey S Levin; Stephen R McCauley; Kenneth R Smith; J Paul Muizelaar; Donald W Marion; Thomas G Luerssen
Hypothermia on admission in patients with severe brain injury.
Journal of neurotrauma 2002;19(3):293-301.
2001: CG Markgraf; Guy L Clifton; M R Moody
Treatment window for hypothermia in brain injury.
Journal of neurosurgery 2001;95(6):979-83.
2001: Guy L Clifton; Sung C Choi; Emmy R Miller; Harvey S Levin; Kenneth R Smith; J Paul Muizelaar; F C Wagner; Donald W Marion; Thomas G Luerssen
Intercenter variance in clinical trials of head trauma--experience of the National Acute Brain Injury Study: Hypothermia.
Journal of neurosurgery 2001;95(5):751-5.
2001: Stephen R McCauley; Harvey S Levin; M Vanier; Jean-Michel Mazaux; Corwin Boake; P R Goldfader; D Rockers; M Butters; D A Kareken; J Lambert; Guy L Clifton
The neurobehavioural rating scale-revised: sensitivity and validity in closed head injury assessment.
Journal of neurology, neurosurgery, and psychiatry 2001;71(5):643-51.
2001: S A Brown; Stephen R McCauley; Harvey S Levin; Corwin Boake; P R Goldfader; S D McCormick; D Rockers; M Butters; D A Kareken; D Gostnell; Guy L Clifton
Factor analysis of an outcome interview for use in clinical trials of traumatically brain-injured patients: a preliminary study.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2001;80(3):196-205.
2001: Guy L Clifton; Emmy R Miller; Sung C Choi; Harvey S Levin; Stephen R McCauley; Kenneth R Smith; J Paul Muizelaar; F C Wagner; Donald W Marion; Thomas G Luerssen; R M Chesnut; M Schwartz
Lack of effect of induction of hypothermia after acute brain injury.
The New England journal of medicine 2001;344(8):556-63.
2001: CG Markgraf; Guy L Clifton; M Aguirre; S F Chaney; C Knox-Du Bois; K Kennon; N Verma
Injury severity and sensitivity to treatment after controlled cortical impact in rats.
Journal of neurotrauma 2001;18(2):175-86.
1999: L L Zou; L Huang; Ronald L Hayes; C Black; YH Qiu; J Regino Perez-Polo; Weidong Le; Guy L Clifton; Keyi Yang
Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications.
Gene therapy 1999;6(6):994-1005.
1998: RM Posmantur; Xiurong Zhao; Andreas Kampfl; Guy L Clifton; Ronald L Hayes
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
Neurochemical research 1998;23(10):1265-76.
1998: Randall S Scheibel; Harvey S Levin; Guy L Clifton
Completion rates and feasibility of outcome measures: experience in a multicenter clinical trial of systemic hypothermia for severe head injury.
Journal of neurotrauma 1998;15(9):685-92.
1998: Ronald L Hayes; Kevin Wang; Andreas Kampfl; RM Posmantur; JK Newcomb; Guy L Clifton
Potential contribution of proteases to neuronal damage.
Drug news & perspectives 1998;11(4):215-22.
1998: YH Qiu; Xiurong Zhao; Ronald L Hayes; J Regino Perez-Polo; Brian Pike; L Huang; Guy L Clifton; Keyi Yang
Activation of phosphatidylinositol 3-kinase by brain-derived neurotrophic factor gene transfection in septo-hippocampal cultures.
Journal of neuroscience research 1998;52(2):192-200.
1998: C Edward Dixon; CG Markgraf; Filippo Flavio Angileri; Brian Pike; BM Wolfson; JK Newcomb; M M Bismar; A J Blanco; Guy L Clifton; Ronald L Hayes
Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat.
Journal of neurotrauma 1998;15(2):95-103.
1998: Xiurong Zhao; RM Posmantur; Andreas Kampfl; S J Liu; Kevin Wang; JK Newcomb; Brian Pike; Guy L Clifton; Ronald L Hayes
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(2):161-7.
1997: Keyi Yang; X S Mu; Ronald L Hayes; YH Qiu; F L Sorgi; L Huang; Guy L Clifton
DC-Chol liposome-mediated gene transfer in rat spinal cord.
Neuroreport 1997;8(9-10):2355-8.
1997: JK Newcomb; Andreas Kampfl; RM Posmantur; Xiurong Zhao; Brian Pike; S J Liu; Guy L Clifton; Ronald L Hayes
Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat.
Journal of neurotrauma 1997;14(6):369-83.
1997: K Yang; Guy L Clifton; Ronald L Hayes
Gene therapy for central nervous system injury: the use of cationic liposomes: an invited review.
Journal of neurotrauma 1997;14(5):281-97.
1997: RM Posmantur; Andreas Kampfl; R Siman; J Liu; Xiurong Zhao; Guy L Clifton; Ronald L Hayes
A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat.
Neuroscience 1997;77(3):875-88.
1997: Andreas Kampfl; RM Posmantur; Xiurong Zhao; Erich Schmutzhard; Guy L Clifton; Ronald L Hayes
Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: implications for pathology and therapy: a review and update.
Journal of neurotrauma 1997;14(3):121-34.
1996: Andreas Kampfl; RM Posmantur; Ralph A. Nixon; F Grynspan; Xiurong Zhao; S J Liu; JK Newcomb; Guy L Clifton; Ronald L Hayes
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
Journal of neurochemistry 1996;67(4):1575-83.
1996: W Le; Keyi Yang; J S Whitson; Guy L Clifton; Ronald L Hayes
Liposome-mediated NGF gene transfection increases ChAT activity in CNS cell cultures.
Neuroreport 1996;7(3):710-2.
1996: Andreas Kampfl; Xiurong Zhao; J S Whitson; RM Posmantur; C Edward Dixon; Keyi Yang; Guy L Clifton; Ronald L Hayes
Calpain inhibitors protect against depolarization-induced neurofilament protein loss of septo-hippocampal neurons in culture.
The European journal of neuroscience 1996;8(2):344-52.
1996: Y Iwamoto; Keyi Yang; Guy L Clifton; Ronald L Hayes
Liposome-mediated BDNF cDNA transfer in intact and injured rat brain.
Neuroreport 1996;7(2):609-12.
1996: RM Posmantur; Andreas Kampfl; S J Liu; K Heck; W C Taft; Guy L Clifton; Ronald L Hayes
Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: an immunofluorescence study.
Journal of neuropathology and experimental neurology 1996;55(1):68-80.
1995: Guy L Clifton
Systemic hypothermia in treatment of severe brain injury: a review and update.
Journal of neurotrauma 1995;12(5):923-7.
1995: C Edward Dixon; J Bao; K M Johnson; Keyi Yang; J Whitson; Guy L Clifton; Ronald L Hayes
Basal and scopolamine-evoked release of hippocampal acetylcholine following traumatic brain injury in rats.
Neuroscience letters 1995;198(2):111-4.
1995: Andreas Kampfl; J S Whitson; Xiurong Zhao; RM Posmantur; Guy L Clifton; Ronald L Hayes
Calpain inhibitors reduce depolarization induced loss of tau protein in primary septo-hippocampal cultures.
Neuroscience letters 1995;194(3):149-52.
1995: Ronald L Hayes; Keyi Yang; J S Whitson; J J Xue; Andreas Kampfl; X S Mu; Xiurong Zhao; F Faustinella; Guy L Clifton
Rescue of injury-induced neurofilament loss by BDNF gene transfection in primary septo-hippocampal cell cultures.
Neuroscience letters 1995;191(1-2):121-5.
1993: W C Taft; Keyi Yang; C Edward Dixon; Guy L Clifton; Ronald L Hayes
Hypothermia attenuates the loss of hippocampal microtubule-associated protein 2 (MAP2) following traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(5):796-802.
1993: Guy L Clifton; Jeffrey S Kreutzer; S C Choi; C W Devany; Howard M Eisenberg; M A Foulkes; J A Jane; A Marmarou; L F Marshall
Relationship between Glasgow Outcome Scale and neuropsychological measures after brain injury.
Neurosurgery 1993;33(1):34-8; discussion 38-9.
1993: Guy L Clifton; S Allen; P Barrodale; P Plenger; J Berry; S Koch; J Fletcher; Ronald L Hayes; S C Choi
A phase II study of moderate hypothermia in severe brain injury.
Journal of neurotrauma 1993;10(3):263-71; discussion 273.
1992: Guy L Clifton; S Allen; J Berry; S M Koch
Systemic hypothermia in treatment of brain injury.
Journal of neurotrauma 1992;9 Suppl 2():S487-95.
1991: J Y Jiang; Bruce G Lyeth; Guy L Clifton; Larry W Jenkins; Robert J Hamm; Ronald L Hayes
Relationship between body and brain temperature in traumatically brain-injured rodents.
Journal of neurosurgery 1991;74(3):492-6.
1991: Guy L Clifton; J Y Jiang; Bruce G Lyeth; Larry W Jenkins; Robert J Hamm; Ronald L Hayes
Marked protection by moderate hypothermia after experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(1):114-21.
1990: Bruce G Lyeth; Larry W Jenkins; Robert J Hamm; C Edward Dixon; Linda L Phillips; Guy L Clifton; Harold F Young; Ronald L Hayes
Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat.
Brain research 1990;526(2):249-58.
1990: L P Miller; Bruce G Lyeth; Larry W Jenkins; L Oleniak; D Panchision; Robert J Hamm; Linda L Phillips; C Edward Dixon; Guy L Clifton; Ronald L Hayes
Excitatory amino acid receptor subtype binding following traumatic brain injury.
Brain research 1990;526(1):103-7.
1990: Ronald L Hayes; Bruce G Lyeth; Larry W Jenkins; R Zimmerman; T K McIntosh; Guy L Clifton; Harold F Young
Possible protective effect of endogenous opioids in traumatic brain injury.
Journal of neurosurgery 1990;72(2):252-61.
1989: Guy L Clifton; W C Taft; R E Blair; S C Choi; Robert J Delorenzo
Conditions for pharmacologic evaluation in the gerbil model of forebrain ischemia.
Stroke; a journal of cerebral circulation 1989;20(11):1545-52.
1989: W C Taft; Guy L Clifton; R E Blair; Robert J Delorenzo
Phenytoin protects against ischemia-produced neuronal cell death.
Brain research 1989;483(1):143-8.
1989: Larry W Jenkins; K Moszynski; Bruce G Lyeth; W Lewelt; D S DeWitt; A Allen; C Edward Dixon; John T Povlishock; T J Majewski; Guy L Clifton
Increased vulnerability of the mildly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury.
Brain research 1989;477(1-2):211-24.
1989: Guy L Clifton; Bruce G Lyeth; Larry W Jenkins; W C Taft; R J DeLorenzo; Ronald L Hayes
Effect of D, alpha-tocopheryl succinate and polyethylene glycol on performance tests after fluid percussion brain injury.
Journal of neurotrauma 1989;6(2):71-81.
1988: Claudia S Robertson; Guy L Clifton; Robert Grossman; C N Ou; J Clay Goodman; P Borum; S Bejot; P Barrodale
Alterations in cerebral availability of metabolic substrates after severe head injury.
The Journal of trauma 1988;28(11):1523-32.
1988: W C Taft; K A Tennes-Rees; R E Blair; Guy L Clifton; Robert J Delorenzo
Cerebral ischemia decreases endogenous calcium-dependent protein phosphorylation in gerbil brain.
Brain research 1988;447(1):159-63.
1988: A Saija; Susan E Robinson; Bruce G Lyeth; C Edward Dixon; T Yamamoto; Guy L Clifton; Ronald L Hayes
The effects of scopolamine and traumatic brain injury on central cholinergic neurons.
Journal of neurotrauma 1988;5(2):161-70.
1988: Ronald L Hayes; Y Katayama; Larry W Jenkins; Bruce G Lyeth; Guy L Clifton; J Gunter; John T Povlishock; Harold F Young
Regional rates of glucose utilization in the cat following concussive head injury.
Journal of neurotrauma 1988;5(2):121-37.
1988: Larry W Jenkins; Bruce G Lyeth; W Lewelt; K Moszynski; Douglas S DeWitt; R L Balster; L P Miller; Guy L Clifton; H F Young; Ronald L Hayes
Combined pretrauma scopolamine and phencyclidine attenuate posttraumatic increased sensitivity to delayed secondary ischemia.
Journal of neurotrauma 1988;5(4):275-87.
1988: Ronald L Hayes; Larry W Jenkins; Bruce G Lyeth; Robert L Balster; Susan E Robinson; Guy L Clifton; J F Stubbins; Harold F Young
Pretreatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury.
Journal of neurotrauma 1988;5(4):259-74.