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Olivier Cloarec

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TOP 3
Claire Alexandra Merrifield; Jeremy Kirk Nicholson; Jake Thomas Midwinter Pearce; Francois-Pierre Martin; Mick Bailey; Sandrine Paule Claus; Olivier Cloarec; Marc-Emmanuel Dumas; Swantje Duncker; Silke Sophie Heinzmann; Sunil Kochhar; Marie Claire Lewis; Annick Mercenier; Elaine Holmes
Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818.
Beatriz Jiménez; Hector C Keun; James Kinross; Reza Mirnezami; Olivier Cloarec; Ara Darzi; Robert D Goldin; Elaine Holmes; Paul Ziprin; Jeremy K Nicholson
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Judith M Fonville; Josephine Bunch; Claire Carter; Olivier Cloarec; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Robust data processing and normalization strategy for MALDI mass spectrometric imaging.

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All Publications

2013: Claire Alexandra Merrifield; Jeremy Kirk Nicholson; Jake Thomas Midwinter Pearce; Francois-Pierre Martin; Mick Bailey; Sandrine Paule Claus; Olivier Cloarec; Marc-Emmanuel Dumas; Swantje Duncker; Silke Sophie Heinzmann; Sunil Kochhar; Marie Claire Lewis; Annick Mercenier; Elaine Holmes
Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818.
Gut 2013;62(6):842-51.
2013: Beatriz Jiménez; Hector C Keun; James Kinross; Reza Mirnezami; Olivier Cloarec; Ara Darzi; Robert D Goldin; Elaine Holmes; Paul Ziprin; Jeremy K Nicholson
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Journal of proteome research 2013;12(2):959-68.
2012: Judith M Fonville; Josephine Bunch; Claire Carter; Olivier Cloarec; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Robust data processing and normalization strategy for MALDI mass spectrometric imaging.
Analytical chemistry 2012;84(3):1310-9.
2009: Cristina Legido-Quigley; Olivier Cloarec; David A Parker; Gerard M Murphy; Elaine Holmes; John C Lindon; Jeremy K Nicholson; Ragai R Mitry; Hector Vilca-Melendez; Mohamed Rela; Anil Dhawan; Nigel Heaton
First example of hepatocyte transplantation to alleviate ornithine transcarbamylase deficiency, monitored by NMR-based metabonomics.
Bioanalysis 2009;1(9):1527-35.
2009: Ruey Leng Loo; Muireann Coen; Timothy M D Ebbels; Olivier Cloarec; Elaine Maibaum; Magda Bictash; Ivan K S Yap; Paul Elliott; Jeremiah Stamler; Jeremy K Nicholson; Elaine Holmes
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.
Analytical chemistry 2009;81(13):5119-29.
2009: Anthony D Maher; Olivier Cloarec; Prasad Patki; Michael Craggs; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy.
Analytical chemistry 2009;81(1):288-95.
2008: Yulan Wang; Olivier Cloarec; Huiru Tang; John C Lindon; Elaine Holmes; Sunil Kochhar; Jeremy K Nicholson
Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies.
Analytical chemistry 2008;80(4):1058-66.
2008: Stephen J Bruce; Pär Jonsson; Henrik Antti; Olivier Cloarec; Johan Trygg; Stefan L Marklund; Thomas Moritz
Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis.
Analytical biochemistry 2008;372(2):237-49.
2008: Sandrine P Claus; Tsz M Tsang; Yulan Wang; Olivier Cloarec; Eleni Skordi; François-Pierre Martin; Francois-Pierre Martin; Alastair Ross; Sunil Kochhar; Elaine Holmes; Jeremy K Nicholson
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.
Molecular systems biology 2008;4():219.
2008: Jane F Fearnside; Marc-Emmanuel Dumas; Alice R Rothwell; Steven P Wilder; Olivier Cloarec; Ayo TOYE; Christine Blancher; Elaine Holmes; Roger Tatoud; Richard H Barton; James Scott; Jeremy K Nicholson; Dominique Gauguier
Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice.
PloS one 2008;3(2):e1668.
2007: Muireann Coen; Young-Shick Hong; Olivier Cloarec; Cindy M Rhode; Michael D Reily; Donald G Robertson; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.
Analytical chemistry 2007;79(23):8956-66.
2007: Eleni Skordi; Ivan K S Yap; Sandrine P Claus; Francois-Pierre Martin; Olivier Cloarec; Johan Lindberg; Ina Schuppe-Koistinen; Elaine Holmes; Jeremy K Nicholson
Analysis of time-related metabolic fluctuations induced by ethionine in the rat.
Journal of proteome research 2007;6(12):4572-81.
2007: Ayo TOYE; M E Dumas; Christine Blancher; A R Rothwell; Jane F Fearnside; Steven P Wilder; Marie-Thérèse Bihoreau; Olivier Cloarec; I Azzouzi; S Young; Richard H Barton; E Holmes; Mark I McCarthy; Roger Tatoud; J K Nicholson; J Scott; Dominique Gauguier
Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.
Diabetologia 2007;50(9):1867-79.
2007: Leon M Smith; Anthony D Maher; Olivier Cloarec; Mattias Rantalainen; Huiru Tang; Paul Elliott; Jeremiah Stamler; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples.
Analytical chemistry 2007;79(15):5682-9.
2007: Olivier Cloarec; Alison Campbell; Li-Hong Tseng; Ulrich Braumann; Manfred Spraul; Graeme Scarfe; Richard Weaver; Jeremy K Nicholson
Virtual chromatographic resolution enhancement in cryoflow LC-NMR experiments via statistical total correlation spectroscopy.
Analytical chemistry 2007;79(9):3304-11.
2007: Elaine Holmes; Ruey Leng Loo; Olivier Cloarec; Muireann Coen; Huiru Tang; Elaine Maibaum; Stephen Bruce; Queenie Chan; Paul Elliott; Jeremiah Stamler; Ian D Wilson; John C Lindon; Jeremy K Nicholson
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Analytical chemistry 2007;79(7):2629-40.
2007: Francois-Pierre Martin; Marc-Emmanuel Dumas; Yulan Wang; Cristina Legido-Quigley; Ivan K S Yap; Huiru Tang; Séverine Zirah; Gerard M Murphy; Olivier Cloarec; John C Lindon; norbert sprenger; Laurent B Fay; Sunil Kochhar; Peter van Bladeren; Elaine Holmes; Jeremy K Nicholson
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology 2007;3():112.
2006: Cinzia Stella; Bridgette M Beckwith-Hall; Olivier Cloarec; Elaine Holmes; John C Lindon; Jonathan Powell; Frans van der Ouderaa; Sheila Bingham; Amanda J Cross; Jeremy K Nicholson
Susceptibility of human metabolic phenotypes to dietary modulation.
Journal of proteome research 2006;5(10):2780-8.
2006: Mattias Rantalainen; Olivier Cloarec; Olaf Beckonert; Ian D Wilson; David Jackson; Robert Tonge; Rachel Rowlinson; Steve Rayner; Janice Nickson; Robert W Wilkinson; Jonathan D Mills; Johan Trygg; Jeremy K Nicholson; Elaine Holmes
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
Journal of proteome research 2006;5(10):2642-55.
2006: Francois-Pierre Martin; Elena F Verdu; Yulan Wang; Marc-Emmanuel Dumas; Ivan K S Yap; Olivier Cloarec; Gabriela E Bergonzelli; Irene Corthesy-Theulaz; Sunil Kochhar; Elaine Holmes; John C Lindon; Stephen Collins; Jeremy K Nicholson
Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.
Journal of proteome research 2006;5(9):2185-93.
2006: Marc-Emmanuel Dumas; Richard H Barton; Ayo TOYE; Olivier Cloarec; Christine Blancher; Alice Rothwell; Jane F Fearnside; Roger Tatoud; Véronique Blanc; John C Lindon; Stephen C Mitchell; Elaine Holmes; Mark I McCarthy; James Scott; Dominique Gauguier; Jeremy K Nicholson
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12511-6.
2006: Derek J Crockford; John C Lindon; Olivier Cloarec; Robert S Plumb; Stephen J Bruce; Séverine Zirah; Paul David Rainville; Chris L Stumpf; Kelly Johnson; Elaine Holmes; Jeremy K Nicholson
Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis.
Analytical chemistry 2006;78(13):4398-408.
2006: Elaine Holmes; Olivier Cloarec; Jeremy K Nicholson
Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids: application to HgCl2 toxicity.
Journal of proteome research 2006;5(6):1313-20.
2006: T Andrew Clayton; John C Lindon; Olivier Cloarec; Henrik Antti; Claude Charuel; Gilles Hanton; Jean-Pierre Provost; Jean-Loic Le Net; David Baker; Rosalind J Walley; Jeremy R Everett; Jeremy K Nicholson
Pharmaco-metabonomic phenotyping and personalized drug treatment.
Nature 2006;440(7087):1073-7.
2006: Andrew Craig; Olivier Cloarec; Elaine Holmes; Jeremy K Nicholson; John C Lindon
Scaling and normalization effects in NMR spectroscopic metabonomic data sets.
Analytical chemistry 2006;78(7):2262-7.
2005: Olivier Cloarec; Marc-Emmanuel Dumas; Andrew Craig; Richard H Barton; Johan Trygg; Jane Hudson; Christine Blancher; Dominique Gauguier; John C Lindon; Elaine Holmes; Jeremy Nicholson
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Analytical chemistry 2005;77(5):1282-9.
2005: Olivier Cloarec; Marc-Emmanuel Dumas; Johan Trygg; Andrew Craig; Richard H Barton; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.
Analytical chemistry 2005;77(2):517-26.
2004: Yulan Wang; Elaine Holmes; Jeremy K Nicholson; Olivier Cloarec; Jacques Chollet; Marcel Tanner; Burton H Singer; Jürg Utzinger
Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12676-81.