FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Timothy Cloughesy

Research Profile

Disorders

Chemicals & Drugs

Concepts & Ideas

Physiology

Procedures

Antineoplastic Combined Chemotherapy Protocols

Co-author Network

Publications

TOP 3
Maxwell Lewis Neal; Jason K Rockhill; Russell C Rockne; Rita Sodt; Andrew D Trister; Sunyoung Ahn; Anne Baldock; Carly A Bridge; Tyler Cloke; Timothy F Cloughesy; Laura Guyman; Albert Lai; Jordan Lange; Maciej M Mrugala; Kristin Swanson
Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression.
Olivier L Chinot; Yannick Kerloëguen; David R Macdonald; Gudrun Zahlmann; Lauren E Abrey; Timothy F Cloughesy
Response assessment criteria for glioblastoma: practical adaptation and implementation in clinical trials of antiangiogenic therapy.
Kourosh M Naeini; Phioanh L Nghiemphu; Heidi S Phillips; Whitney B Pope; Yalda Behbahanian; Reshmi Chowdhury; Timothy F Cloughesy; Ascia Eskin; Robert J Harris; Albert Lai; Benjamin M Ellingson
Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Timothy Cloughesy (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Maxwell Lewis Neal; Jason K Rockhill; Russell C Rockne; Rita Sodt; Andrew D Trister; Sunyoung Ahn; Anne Baldock; Carly A Bridge; Tyler Cloke; Timothy F Cloughesy; Laura Guyman; Albert Lai; Jordan Lange; Maciej M Mrugala; Kristin Swanson
Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression.
Cancer research 2013;73(10):2976-86.
2013: Olivier L Chinot; Yannick Kerloëguen; David R Macdonald; Gudrun Zahlmann; Lauren E Abrey; Timothy F Cloughesy
Response assessment criteria for glioblastoma: practical adaptation and implementation in clinical trials of antiangiogenic therapy.
Current neurology and neuroscience reports 2013;13(5):347.
2013: Kourosh M Naeini; Phioanh L Nghiemphu; Heidi S Phillips; Whitney B Pope; Yalda Behbahanian; Reshmi Chowdhury; Timothy F Cloughesy; Ascia Eskin; Robert J Harris; Albert Lai; Benjamin M Ellingson
Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images.
Neuro-oncology 2013;15(5):626-34.
2013: Robert J Harris; Albert Lai; Heiko Meyer; Yutaka Natsuaki; Phioanh L Nghiemphu; Dominik Paul; Whitney B Pope; Yalda Behbahanian; Timothy F Cloughesy; Sergio Godinez; Benjamin M Ellingson
Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastoma.
Journal of neuro-oncology 2013;112(2):257-66.
2013: Akio Iwanami; Issay Kitabayashi; Jun Kohyama; Tomoo Matsutani; Alvaro Assuncao; Webster K Cavenee; Timothy F Cloughesy; Julie Dang; Frank B Furnari; Beatrice Gini; Ali Nael; Masaya Nakamura; Hideyuki Okano; Yoshiaki Toyama; Huijun Yang; Ciro Zanca; Shaojun Zhu; Paul S Mischel
PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(11):4339-44.
2013: Benjamin M Ellingson; Albert Lai; Linda M Liau; Phioanh L Nghiemphu; Timothy F Cloughesy; Whitney B Pope
Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy.
Neuro-oncology 2013;15(3):382-90.
2013: Robert M Prins; Horacio Soto; Xiaoyan Wang; William H Yong; Emma Young; Timothy F Cloughesy; Richard Everson; Brendan Fong; Albert Lai; Gang Li; Dominique N Lisiero; Linda M Liau
Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013;36(2):152-7.
2013: Maxwell Neal; Jason K Rockhill; Russell C Rockne; Rita Sodt; Sunyoung Ahn; Anne L Baldock; Carly A Bridge; Tyler Cloke; Timothy F Cloughesy; Albert Lai; Maciej M Mrugala; Andrew D Trister; Kristin Swanson
Discriminating survival outcomes in patients with glioblastoma using a simulation-based, patient-specific response metric.
PloS one 2013;8(1):e51951.
2012: Eudocia Q Lee; Victor A Levin; Frank Lieberman; Minesh Mehta; Michael D Prados; H Ian Robins; John J Wright; W K Alfred Yung; Lauren Abrey; Kenneth Aldape; Susan M Chang; Timothy F Cloughesy; Janet E Dancey; Lisa M DeAngelis; Jan Drappatz; Mark R Gilbert; John Kuhn; Kathleen R Lamborn; Patrick Y Wen
Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02.
Neuro-oncology 2012;14(12):1511-8.
2012: Jelena Lazovic; Sichen Li; Linda M Liau; Leili Mirsadraei; David Piccioni; Robert Prins; Horacio Soto; William Yong; Jerry R Lou; Timothy F Cloughesy; Benjamin M Ellingson; Albert Lai; Whitney B Pope
Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation.
Neuro-oncology 2012;14(12):1465-72.
2012: Eudocia Q Lee; Frank S Lieberman; Renee M McGovern; Michael D Prados; Vinay K Puduvalli; Joel M Reid; H Ian Robins; Matthew M Ames; Susan M Chang; Timothy F Cloughesy; Serena Desideri; Jan Drappatz; Igor Espinoza-Delgado; Mark R Gilbert; John G Kuhn; Kathleen R Lamborn; Andrew B Lassman; Jihong Xu; Xiabu Ye; W K Alfred Yung; Patrick Y Wen
Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(21):6032-9.
2012: Robert J Harris; Albert Lai; Phioanh L Nghiemphu; Michael E Phelps; Whitney B Pope; Taryar Zaw; Wei Chen; Timothy F Cloughesy; Johannes Czernin; Benjamin M Ellingson
18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab.
Neuro-oncology 2012;14(8):1079-89.
2012: Whitney B Pope; Michael Prados; Vinay K Puduvalli; Xin Joe Qiao; Patricia Lada Rn; David Schiff; James Vredenburgh; Patrick Y Wen; Jing Wu; Xi Xue; Geoffrey S Young; Wai-Kwan A Yung; Benjamin M Ellingson; Jonathan Goldin; Rajan Jain; Hyun J Kim; Albert Lai; Tom Mikkelsen; Phioanh Nghiemphu; Nina Paleologos; Lauren E Abrey; Dawit Aregawi; Dan Barboriak; Soonmee Cha; Timothy F Cloughesy
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study.
Journal of neuro-oncology 2012;108(3):491-8.
2012: Katherine S Panageas; Andreana L Rivera; H Ian Robins; Brandon G Rocque; Gloria B Roldán Urgoiti; Marc K Rosenblum; David Schiff; Susan A Weaver; Patrick Y Wen; Lauren E Abrey; Kenneth D Aldape; Lynn S Ashby; J Gregory Cairncross; Marc C Chamberlain; Timothy F Cloughesy; Lisa De Angelis; April F Eichler; Barbara J Fisher; Richard M Green; Fabio M Iwamoto; Suresh C Jhanwar; Francois G. Kamar; Keith L Ligon; David N Louis; Warren P Mason; Nina Paleologos; Andrew B Lassman
Initial treatment patterns over time for anaplastic oligodendroglial tumors.
Neuro-oncology 2012;14(6):761-7.
2012: Benjamin M Ellingson; Albert Lai; Shadi Lalezari; Sandy Mong; Kourosh M Naeini; Phioanh L Nghiemphu; Timothy F Cloughesy; Taryar Zaw; Whitney B Pope
Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)-MRI estimates of cerebral blood volume (CBV) in human gliomas.
Journal of magnetic resonance imaging : JMRI 2012;35(6):1472-7.
2012: Franziska Walter; Martin A Walter; Timothy F Cloughesy; Barbara J Fueger; Albert Lai; Phioanh Nghiemphu; Michael E Phelps; Nagichettiar Satyamurthy; Naveed Wagle; Johannes Czernin
Impact of 3,4-dihydroxy-6-18F-fluoro-L-phenylalanine PET/CT on managing patients with brain tumors: the referring physician's perspective.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(3):393-8.
2012: Benjamin M Ellingson; Robert Harris; Albert Lai; Shadi Lalezari; Linda M Liau; Kourosh M Naeini; Phioanh L Nghiemphu; Jose Carrillo; Timothy F Cloughesy; Naveed Wagle; Taryar Zaw; Whitney B Pope
Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma.
Neuro-oncology 2012;14(3):333-43.
2012: Whitney B Pope; Robert M Prins; Noriko Salamon; David P Schenkein; Horacio Soto; Shinsan M Su; Neil Wilson; Hong Wu; Katharine E Yen; William H Yong; M Albert Thomas; Mark A Bittinger; Arthur P Chou; Timothy F Cloughesy; Edward Driggers; Valeria R Fantin; Hyun G Jang; Harley I Kornblum; Albert Lai; Rajakumar Nagarajan; Linda M Liau
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.
Journal of neuro-oncology 2012;107(1):197-205.
2012: Benjamin M Ellingson; Robert J Harris; Hassana Ibrahim; Shadi Lalezari; Kourosh M Naeini; Phioanh L Nghiemphu; Heidi Phillips; Whitney B Pope; Taryar M Zaw; Timothy F Cloughesy; Albert Lai
Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas.
NeuroImage 2012;59(2):908-16.
2012: Ingo K Mellinghoff; Paul S Mischel; Nikolaus Schultz; Timothy F Cloughesy
Will kinase inhibitors make it as glioblastoma drugs?
Current topics in microbiology and immunology 2012;355():135-69.
2012: Benjamin M Ellingson; Albert Lai; Shadi Lalezari; Paul S Mischel; Kourosh Motevalibashinaeini; Phioanh L Nghiemphu; Timothy F Cloughesy; Taryar Zaw; Whitney B Pope
Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab.
Journal of neuro-oncology 2012;106(1):111-9.
2011: Phioanh Leia Nghiemphu; Michael D Prados; H Ian Robins; Alejandro Torres-Trejo; Patrick Y Wen; Lauren E Abrey; Susan M Chang; Timothy F Cloughesy; Lisa M DeAngelis; Alexis Demopoulos; Jan Drappatz; Howard A Fine; Karen Fink; Santosh Kesari; Kathleen R Lamborn; Andrew B Lassman; Frank S Lieberman; Mark G Malkin; Minesh Mehta
A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma.
International journal of radiation oncology, biology, physics 2011;81(5):1422-7.
2011: Kazuhiro Tanaka; Harry V Vinters; Huijun Yang; William H Yong; Yinan Zhang; Shaojun Zhu; David Nathanson; Amanda Rinkenbaugh; David Akhavan; Ali Nael Amzajerdi; Ivan Babic; Albert S Baldwin; Webster K Cavenee; Timothy F Cloughesy; Hancai Dan; Julie Dang; Jason De Jesus; Christian C Dibble; Joseph F Gera; Beatrice Gini; Deliang Guo; Brendan D Manning; Paul S Mischel
Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance.
Cancer discovery 2011;1(6):524-38.
2011: Deliang Guo; Cynthia Hong; Tiffany T Huang; Akio Iwanami; C David James; Daisuke Kuga; Dominique D Lisiero; Minesh Mehta; Ingo K Mellinghoff; David Akhavan; Ali Nael Amzajerdi; Ivan Babic; Arnab Chakravarti; Timothy F Cloughesy; Julie Dang; Lisa M Deangelis; Jason Dejesus; Beatrice Gini; David Nathanson; Michael D Prados; Robert M Prins; Felicia Reinitz; H Ian Robins; Horacio Soto; Kazuhiro Tanaka; Peter Tontonoz; Patrick Y Wen; Mary Youssef; Shaojun Zhu; Paul S Mischel
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.
Cancer discovery 2011;1(5):442-56.
2011: Benjamin M Ellingson; Albert Lai; Shadi Lalezari; Paul Mischel; Phioanh L Nghiemphu; Timothy F Cloughesy; Kathleen M Schmainda; Whitney B Pope
Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab.
Neuro-oncology 2011;13(10):1151-61.
2011: Jennifer L Clarke; Michele M Ennis; Lauren Abrey; Kenneth Aldape; Susan M Chang; Timothy F Cloughesy; Lisa M Deangelis; Howard A Fine; Mark R Gilbert; John Kuhn; Kathleen R Lamborn; Frank S Lieberman; Minesh Mehta; Michael D Prados; H Ian Robins; Patrick Y Wen; W K Alfred Yung
Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?
Neuro-oncology 2011;13(10):1118-24.
2011: Benjamin M Ellingson; Albert Lai; Phioanh L Nghiemphu; Timothy F Cloughesy; Whitney B Pope
Cell invasion, motility, and proliferation level estimate (CIMPLE) maps derived from serial diffusion MR images in recurrent glioblastoma treated with bevacizumab.
Journal of neuro-oncology 2011;105(1):91-101.
2011: Patrick Y Wen; W K Alfred Yung; Tracy T Batchelor; Bruce A Chabner; Susan M Chang; Timothy F Cloughesy; John F de Groot; Keith Flaherty; Evanthia Galanis; Mark R Gilbert; Stuart A Grossman; Minesh Mehta; David Peereboom; Michael D Prados; David A Reardon; David Schiff; Gary K Schwartz; Lisa M DeAngelis
It is time to include patients with brain tumors in phase I trials in oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(24):3211-3.
2011: Benjamin M Ellingson; Albert Lai; Linda M Liau; Phioanh L Nghiemphu; Timothy F Cloughesy; Whitney B Pope
High order diffusion tensor imaging in human glioblastoma.
Academic radiology 2011;18(8):947-54.
2011: John F de Groot; Lisa De Angelis; Mark Gilbert; B Nebiyou Bekele; Kevin A Camphausen; Alice Chen; Timothy F Cloughesy; Andrew Lassman; Jun Liu; Minesh Mehta; Yuji Piao; Michael Prados; H Ian Robins; Hai Tran; Patrick Y Wen; Hua-Kang Wu; W K A Yung; John V Heymach
Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(14):4872-81.
2011: John F de Groot; Lisa De Angelis; Mark R Gilbert; Edward F Jackson; Kathleen R Lamborn; Andrew B Lassman; Frank S Lieberman; Minesh Mehta; Michael D Prados; H Ian Robins; Kenneth Aldape; Susan M Chang; Alice Chen; Timothy F Cloughesy; Jun Yao; W K Alfred Yung; Patrick Y Wen
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(19):2689-95.
2011: Andrew B Kay; Clara E Magyar; Sergey Mareninov; Steven S Silver; Timothy F Cloughesy; Sarah Dry; Daniel K Estrada; William H Yong
Considerations for uniform and accurate biospecimen labelling in a biorepository and research environment.
Journal of clinical pathology 2011;64(7):634-6.
2011: Andrew B Lassman; Fabio M Iwamoto; Timothy F Cloughesy; Kenneth D Aldape; Andreana L Rivera; April F Eichler; David N Louis; Nina Paleologos; Barbara J Fisher; Lynn S Ashby; J Gregory Cairncross; Gloria B Roldán; Patrick Y Wen; Keith L Ligon; David Schiff; H Ian Robins; Brandon G Rocque; Marc C Chamberlain; Warren P Mason; Susan A Weaver; Richard M Green; Francois G. Kamar; Lauren E Abrey; Lisa De Angelis; Suresh C Jhanwar; Marc K Rosenblum; Katherine S Panageas
International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors.
Neuro-oncology 2011;13(6):649-59.
2011: Orestes E Solis; Rupal Mehta; Albert Lai; Rashi I Mehta; Lama O Farchoukh; Richard M Green; Jerry C Cheng; Sathima Natarajan; Harry V Vinters; Timothy F Cloughesy; William H Yong
Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases.
Journal of neuro-oncology 2011;102(3):477-84.
2011: Benjamin M Ellingson; Timothy F Cloughesy; Albert Lai; Phioanh L Nghiemphu; Paul Mischel; Whitney B Pope
Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab.
Neuro-oncology 2011;13(4):401-9.
2011: Patrick Y Wen; David Schiff; Timothy F Cloughesy; Jeffrey J Raizer; John Laterra; Melanie Smitt; Michael Wolf; Kelly S Oliner; Abraham Anderson; Min Zhu; Elwyn Loh; David A Reardon
A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma.
Neuro-oncology 2011;13(4):437-46.
2011: David A Reardon; Evanthia Galanis; John F DeGroot; Timothy F Cloughesy; Jeffrey S Wefel; Kathleen R Lamborn; Andrew B Lassman; Mark R Gilbert; John H Sampson; Wolfgang Wick; Marc C Chamberlain; David R Macdonald; Minesh Mehta; Michael A Vogelbaum; Susan M Chang; Martin J van den Bent; Patrick Y Wen
Clinical trial end points for high-grade glioma: the evolving landscape.
Neuro-oncology 2011;13(3):353-61.
2011: Whitney B Pope; Q Xia; Virginia Paton; A Das; J Hambleton; H J Kim; J Huo; M S Brown; J Goldin; Timothy F Cloughesy
Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab.
Neurology 2011;76(5):432-7.
2011: Albert Lai; Anh Tran; Phioanh L Nghiemphu; Whitney B Pope; Orestes E Solis; Michael T Selch; Emese Filka; William H Yong; Paul Mischel; Linda M Liau; Surasak Phuphanich; Keith Black; Scott Peak; Richard M Green; Cynthia E Spier; Tatjana Kolevska; Jonathan Polikoff; Louis Fehrenbacher; Robert Elashoff; Timothy F Cloughesy
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(2):142-8.
2011: Timothy F Cloughesy; Paul Mischel
New strategies in the molecular targeting of glioblastoma: how do you hit a moving target?
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(1):6-11.
2011: Michael Prados; Timothy F Cloughesy; Meghna Samant; Liang Fang; Patrick Y Wen; Tom Mikkelsen; David Schiff; Lauren E Abrey; W K Alfred Yung; Nina Paleologos; M Kelly Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S Friedman
Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab.
Neuro-oncology 2011;13(1):143-51.
2010: Barbara J Fueger; Johannes Czernin; Timothy F Cloughesy; Daniel H S Silverman; Cheri L Geist; Martin A Walter; Christiaan Schiepers; Phioanh Nghiemphu; Albert Lai; Michael E Phelps; Wei Chen
Correlation of 6-18F-fluoro-L-dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(10):1532-8.
2010: W K Alfred Yung; James J Vredenburgh; Timothy F Cloughesy; Phioanh Nghiemphu; Barbara Klencke; Mark R Gilbert; David A Reardon; Michael D Prados
Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study.
Neuro-oncology 2010;12(10):1061-70.
2010: Eduard H Panosyan; Dan R Laks; Michael Masterman-Smith; Jack Mottahedeh; William H Yong; Timothy F Cloughesy; Jorge A Lazareff; Paul Mischel; Theodore B Moore; Harley I Kornblum
Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation.
Pediatric blood & cancer 2010;55(4):644-51.
2010: David Akhavan; Timothy F Cloughesy; Paul Mischel
mTOR signaling in glioblastoma: lessons learned from bench to bedside.
Neuro-oncology 2010;12(8):882-9.
2010: Yohan Lee; Jason Liu; Shilpa Patel; Timothy F Cloughesy; Albert Lai; Haumith Farooqi; David Seligson; Jun Dong; Linda Liau; Donald Becker; Paul Mischel; Soheil Shams; Stanley Nelson
Genomic landscape of meningiomas.
Brain pathology (Zurich, Switzerland) 2010;20(4):751-62.
2010: Patrick Y Wen; David R Macdonald; David A Reardon; Timothy F Cloughesy; A Gregory Sorensen; Evanthia Galanis; John Degroot; Wolfgang Wick; Mark R Gilbert; Andrew B Lassman; Christina Tsien; Tom Mikkelsen; Eric T Wong; Marc C Chamberlain; Roger Stupp; Kathleen R Lamborn; Michael A Vogelbaum; Martin J van den Bent; Susan M Chang
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(11):1963-72.
2010: Igor Vivanco; Daniel Rohle; Matthias Versele; Akio Iwanami; Daisuke Kuga; Barbara Oldrini; Kazuhiro Tanaka; Julie Dang; Sara Kubek; NICOLAOS PALASKAS; Teli Hsueh; Michael Evans; David Mulholland; Daniel Wolle; Sigrid Rajasekaran; Ayyappan Rajasekaran; Linda M Liau; Timothy F Cloughesy; Ivan Dikic; Cameron Brennan; Hong Wu; Paul Mischel; Timothy Perera; Ingo K Mellinghoff
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6459-64.
2010: Melanie Kappadakunnel; Ascia Eskin; Jun Dong; Stanley F Nelson; Paul S Mischel; Linda M Liau; Phioanh Ngheimphu; Albert Lai; Timothy F Cloughesy; Jonathan Goldin; Whitney B Pope
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone.
Journal of neuro-oncology 2010;96(3):359-67.
2010: Deliang Guo; Timothy F Cloughesy; Caius G Radu; Paul Mischel
AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas.
Cell cycle (Georgetown, Tex.) 2010;9(2):211-2.
2010: James J Vredenburgh; Timothy F Cloughesy; Meghna Samant; Michael Prados; Patrick Y Wen; Tom Mikkelsen; David Schiff; Lauren E Abrey; W K Alfred Yung; Nina Paleologos; Martin K Nicholas; Randy Jensen; Asha Das; Henry S Friedman
Corticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN study.
The oncologist 2010;15(12):1329-34.
2010: Jeffrey J Raizer; Lauren E Abrey; Andrew B Lassman; Susan M Chang; Kathleen R Lamborn; John Kuhn; W K Alfred Yung; Mark R Gilbert; Kenneth A Aldape; Patrick Y Wen; Howard A Fine; Minesh Mehta; Lisa De Angelis; Frank Lieberman; Timothy F Cloughesy; H Ian Robins; Janet Dancey; Michael D Prados
A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy.
Neuro-oncology 2010;12(1):95-103.
2010: Jeffrey J Raizer; Lauren E Abrey; Andrew B Lassman; Susan M Chang; Kathleen R Lamborn; John Kuhn; W K Alfred Yung; Mark R Gilbert; Kenneth Aldape; Patrick Y Wen; Howard A Fine; Minesh Mehta; Lisa De Angelis; Frank Lieberman; Timothy F Cloughesy; H Ian Robins; Janet Dancey; Michael D Prados
A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas.
Neuro-oncology 2010;12(1):87-94.
2010: Selvaraju Veeriah; Barry S Taylor; Shasha Meng; Fang Fang; Emrullah Yilmaz; Igor Vivanco; Manickam Janakiraman; Nikolaus Schultz; Aphrothiti J Hanrahan; William Pao; Marc Ladanyi; Chris Sander; Adriana Heguy; Eric C Holland; Philip B Paty; Paul Mischel; Linda Liau; Timothy F Cloughesy; Ingo K Mellinghoff; David B Solit; Timothy Chan
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
Nature genetics 2010;42(1):77-82.
2010: Andrew D Norden; Jeffrey J Raizer; Lauren E Abrey; Kathleen R Lamborn; Andrew B Lassman; Susan M Chang; W K Alfred Yung; Mark R Gilbert; Howard A Fine; Minesh Mehta; Lisa De Angelis; Timothy F Cloughesy; H Ian Robins; Kenneth Aldape; Janet Dancey; Michael D Prados; Frank Lieberman; Patrick Y Wen
Phase II trials of erlotinib or gefitinib in patients with recurrent meningioma.
Journal of neuro-oncology 2010;96(2):211-7.
2009: Patrick Y Wen; W K Alfred Yung; Kathleen R Lamborn; Andrew D Norden; Timothy F Cloughesy; Lauren E Abrey; Howard A Fine; Susan M Chang; H Ian Robins; Karen Fink; Lisa De Angelis; Minesh Mehta; Emmanuelle di Tomaso; Jan Drappatz; Santosh kesari; Keith L Ligon; Ken Aldape; Rakesh K Jain; Charles D Stiles; Merrill J Egorin; Michael D Prados
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).
Neuro-oncology 2009;11(6):853-60.
2009: Henry S Friedman; Michael D Prados; Patrick Y Wen; Tom Mikkelsen; David Schiff; Lauren E Abrey; W K Alfred Yung; Nina Paleologos; Martin K Nicholas; Randy Jensen; James J Vredenburgh; Jane Huang; Maoxia Zheng; Timothy F Cloughesy
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(28):4733-40.
2009: Kan V Lu; Shaojun Zhu; Anna Cvrljevic; Tiffany T Huang; Shawn Sarkaria; David Ahkavan; Jeff Dang; Eduard B Dinca; Seema B Plaisier; Isaac Oderberg; Yohan Lee; Zugen Chen; Jeremy S Caldwell; Yongmin Xie; Joseph A Loo; David Seligson; Arnab Chakravari; Francis Y Lee; Roberto Weinmann; Timothy F Cloughesy; Stanley F Nelson; Gabriele Bergers; Thomas Graeber; Frank B Furnari; C David James; Webster K Cavenee; Terrance G Johns; Paul S Mischel
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
Cancer research 2009;69(17):6889-98.
2009: Deliang Guo; Isabel J Hildebrandt; Robert M Prins; Horacio Soto; Mary M Mazzotta; Julie Dang; Johannes Czernin; John Y-J Shyy; Andrew D Watson; Michael Phelps; Caius G Radu; Timothy F Cloughesy; Paul S Mischel
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12932-7.
2009: Akio Iwanami; Timothy F Cloughesy; Paul S Mischel
Striking the balance between PTEN and PDK1: it all depends on the cell context.
Genes & development 2009;23(15):1699-704.
2009: Qinghai Liu; David H Nguyen; Qinghua Dong; Peter Shitaku; Kenneth Chung; On Ying Liu; Jonathan L Tso; Jason Y Liu; Veerauo Konkankit; Timothy F Cloughesy; Paul S Mischel; Timothy F Lane; Linda M Liau; Stanley F Nelson; Cho-Lea Tso
Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors.
Journal of neuro-oncology 2009;94(1):1-19.
2009: Whitney B Pope; Hyun J Kim; Jing Huo; Jeffry R Alger; Matthew S Brown; David Gjertson; Victor Sai; Jonathan R Young; Leena Tekchandani; Timothy F Cloughesy; Paul S Mischel; Albert Lai; Phioanh Nghiemphu; Syed Rahmanuddin; Jonathan G Goldin
Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment.
Radiology 2009;252(1):182-9.
2009: Tiffany T Huang; Shawn M Sarkaria; Timothy F Cloughesy; Paul S Mischel
Targeted therapy for malignant glioma patients: lessons learned and the road ahead.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(3):500-12.
2009: P L Nghiemphu; Wei Liu; Yohan Lee; T Than; C Graham; Albert Lai; R M Green; Whitney B Pope; Linda M Liau; Paul S Mischel; Stanley F Nelson; Robert Elashoff; Timothy F Cloughesy
Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience.
Neurology 2009;72(14):1217-22.
2009: Dan R Laks; Michael Masterman-Smith; Koppany Visnyei; brigitte Angénieux; Nicholas M Orozco; Ian Foran; William H Yong; Harry V Vinters; Linda M Liau; Jorge A Lazareff; Paul S Mischel; Timothy F Cloughesy; Steve Horvath; Harley I Kornblum
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.
Stem cells (Dayton, Ohio) 2009;27(4):980-7.
2009: Maya Remington; Jana Chtchetinin; Karen Ancheta; Phioanh Leia Nghiemphu; Timothy F Cloughesy; Albert Lai
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Neuro-oncology 2009;11(1):22-32.
2009: Deliang Guo; Robert M Prins; Julie Dang; Daisuke Kuga; Akio Iwanami; Horacio Soto; Kelly Y Lin; Tiffany T Huang; David Akhavan; M Benjamin Hock; Shaojun Zhu; Ava A Kofman; Steve J Bensinger; William H Yong; Harry V Vinters; Steve Horvath; Andrew D Watson; John Kuhn; H Ian Robins; Minesh Mehta; Patrick Y Wen; Lisa De Angelis; Michael D Prados; Ingo K Mellinghoff; Timothy F Cloughesy; Paul S Mischel
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Science signaling 2009;2(101):ra82.
2009: Nicholas Butowski; Kathleen R Lamborn; Bee L Lee; Michael D Prados; Timothy F Cloughesy; Lisa De Angelis; Lauren E Abrey; Karen Fink; Frank S Lieberman; Minesh Mehta; H Ian Robins; Larry Junck; Andres M Salazar; Susan M Chang
A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas.
Journal of neuro-oncology 2009;91(2):183-9.
2009: Nicholas Butowski; Susan M Chang; Larry Junck; Lisa De Angelis; Lauren E Abrey; Karen Fink; Timothy F Cloughesy; Kathleen R Lamborn; Andres M Salazar; Michael D Prados
A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05).
Journal of neuro-oncology 2009;91(2):175-82.
2008: David A Reardon; Karen L Fink; Tom Mikkelsen; Timothy F Cloughesy; Alison O'Neill; Scott Plotkin; Michael Glantz; Paula Ravin; Jeffrey J Raizer; Keith M Rich; David Schiff; William R Shapiro; Susan Burdette-Radoux; Edward J Dropcho; Sabine M Wittemer; Johannes Nippgen; Martin Picard; L Burt Nabors
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(34):5610-7.
2008: Whitney B Pope; Jenny H Chen; Jun Dong; Marc R J Carlson; Alla Perlina; Timothy F Cloughesy; Linda M Liau; Paul S Mischel; Phioanh Nghiemphu; Albert Lai; Stanley F Nelson
Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis.
Radiology 2008;249(1):268-77.
2008: Susan M Chang; Kathleen R Lamborn; John Kuhn; W K Alfred Yung; Mark R Gilbert; Patrick Y Wen; Howard A Fine; Minesh Mehta; Lisa De Angelis; Frank S Lieberman; Timothy F Cloughesy; H Ian Robins; Lauren E Abrey; Michael D Prados
Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium.
Neuro-oncology 2008;10(4):631-42.
2008: Robert M Prins; Timothy F Cloughesy; Linda M Liau
Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate.
The New England journal of medicine 2008;359(5):539-41.
2008: Suchitra Ananthnarayan; Jennie Bahng; James Roring; Phioanh Nghiemphu; Albert Lai; Timothy F Cloughesy; Whitney B Pope
Time course of imaging changes of GBM during extended bevacizumab treatment.
Journal of neuro-oncology 2008;88(3):339-47.
2008: Phioanh Leia Nghiemphu; Richard M Green; Whitney B Pope; Albert Lai; Timothy F Cloughesy
Safety of anticoagulation use and bevacizumab in patients with glioma.
Neuro-oncology 2008;10(3):355-60.
2008: Michael D Prados; W K A Yung; Patrick Y Wen; Larry Junck; Timothy F Cloughesy; Karen Fink; Susan Chang; H Ian Robins; Janet Dancey; John Kuhn
Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study.
Cancer chemotherapy and pharmacology 2008;61(6):1059-67.
2008: Kathleen R Lamborn; W K Alfred Yung; Susan M Chang; Patrick Y Wen; Timothy F Cloughesy; Lisa De Angelis; H Ian Robins; Frank S Lieberman; Howard A Fine; Karen L Fink; Larry Junck; Lauren E Abrey; Mark R Gilbert; Minesh Mehta; John Kuhn; Kenneth Aldape; Janelle Hibberts; Pamela M Peterson; Michael D Prados
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.
Neuro-oncology 2008;10(2):162-70.
2008: Timothy F Cloughesy; Koji Yoshimoto; Phioanh Nghiemphu; Kevin Brown; Julie Dang; Shaojun Zhu; Teli Hsueh; Yinan Chen; Wei Wang; David Youngkin; Linda M Liau; Neil Martin; Don Becker; Marvin Bergsneider; Albert Lai; Richard Green; Tom Oglesby; Michael Koleto; Jeffrey M. Trent; Steve Horvath; Paul S Mischel; Ingo K Mellinghoff; Charles L Sawyers
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.
PLoS medicine 2008;5(1):e8.
2008: Koji Yoshimoto; Julie Dang; Shaojun Zhu; David Nathanson; Tiffany Huang; Rebecca Dumont; David Seligson; William H Yong; Zhenggang Xiong; Nagesh Rao; Henrik Winther; Arnab Chakravarti; Darell D Bigner; Ingo K Mellinghoff; Steve Horvath; Webster K Cavenee; Timothy F Cloughesy; Paul S Mischel
Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):488-93.
2008: Yohan Lee; Adrienne C Scheck; Timothy F Cloughesy; Albert Lai; Jun Dong; Haumith K Farooqi; Linda M Liau; Steve Horvath; Paul S Mischel; Stanley F Nelson
Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age.
BMC medical genomics 2008;1():52.
2008: Ichiro Nakano; Michael Masterman-Smith; Kuniyasu Saigusa; Andres A Paucar; Steve Horvath; Lorelei Shoemaker; Momoko Watanabe; Alejandra Negro; ruchi bajpai; Amy Howes; Vincent Lelievre; James A Waschek; Jorge A Lazareff; William A Freije; Linda M Liau; Richard J Gilbertson; Timothy F Cloughesy; Daniel Geschwind; Stanley F Nelson; Paul S Mischel; Alexey V Terskikh; Harley I Kornblum
Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.
Journal of neuroscience research 2008;86(1):48-60.
2007: John Kuhn; Susan M Chang; Patrick Y Wen; Timothy F Cloughesy; Harry S Greenberg; David Schiff; Charles Conrad; Karen L Fink; H Ian Robins; Minesh Mehta; Lisa De Angelis; Jeffrey J Raizer; Kenneth Hess; Kathleen R Lamborn; Janet Dancey; Michael D Prados
Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(24):7401-6.
2007: Monica E Loghin; Michael D Prados; Patrick Y Wen; Larry Junck; Frank S Lieberman; Howard A Fine; Karen L Fink; Minesh Metha; John Kuhn; Kathleen R Lamborn; Susan M Chang; Timothy F Cloughesy; Lisa De Angelis; Ian H Robins; Kenneth Aldape; W K Alfred Yung
Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):7133-8.
2007: Wei Chen; Sibylle Delaloye; Daniel H S Silverman; Cheri Geist; Johannes Czernin; James Sayre; Nagichettiar Satyamurthy; Whitney B Pope; Albert Lai; Michael E Phelps; Timothy F Cloughesy
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4714-21.
2007: Christiaan Schiepers; Wei Chen; Timothy F Cloughesy; Magnus Dahlbom; Sung-Cheng Huang
18F-FDOPA kinetics in brain tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(10):1651-61.
2007: Christiaan Schiepers; Wei Chen; Magnus Dahlbom; Timothy F Cloughesy; Carl K Hoh; Sung-Cheng Huang
18F-fluorothymidine kinetics of malignant brain tumors.
European journal of nuclear medicine and molecular imaging 2007;34(7):1003-11.
2007: Marc R J Carlson; Whitney B Pope; Steve Horvath; Jerome G Braunstein; Phioanh Nghiemphu; Cho-Lea Tso; Ingo K Mellinghoff; Albert Lai; Linda M Liau; Paul S Mischel; Jun Dong; Stanley F Nelson; Timothy F Cloughesy
Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2592-8.
2007: Morris D Groves; Vinay K Puduvalli; Susan M Chang; Charles A Conrad; Mark R Gilbert; Ivo W Tremont-Lukats; Ta-Jen Liu; Pamela Peterson; David Schiff; Timothy F Cloughesy; Patrick Y Wen; Harry S Greenberg; Lauren E Abrey; Lisa De Angelis; Kenneth R Hess; Kathleen R Lamborn; Michael D Prados; W K Alfred Yung
A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme.
Journal of neuro-oncology 2007;81(3):271-7.
2007: Ingo K Mellinghoff; Timothy F Cloughesy; Paul S Mischel
PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 1):378-81.
2006: Steve Horvath; Bin Zhang; M Carlson; Kan V Lu; Shaojun Zhu; Felciano Ramon; M F Laurance; W Zhao; S Qi; Z Chen; Y Lee; A C Scheck; Linda M Liau; Hong Wu; Daniel Geschwind; P G Febbo; Harley I Kornblum; Timothy F Cloughesy; Stanley F Nelson; Paul S Mischel
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17402-7.
2006: Cho-Lea Tso; Peter Shintaku; James Chen; Qinghai Liu; Jason Liu; Zugen Chen; Koji Yoshimoto; Paul S Mischel; Timothy F Cloughesy; Linda M Liau; Stanley F Nelson
Primary glioblastomas express mesenchymal stem-like properties.
Molecular cancer research : MCR 2006;4(9):607-19.
2006: Maria Y Wang; Kan V Lu; Shaojun Zhu; Ederlyn Q Dia; Igor Vivanco; Gregory M Shackleford; Webster K Cavenee; Ingo K Mellinghoff; Timothy F Cloughesy; Charles L Sawyers; Paul S Mischel
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.
Cancer research 2006;66(16):7864-9.
2006: Timothy F Cloughesy; Patrick Y Wen; H Ian Robins; Susan M Chang; Morris D Groves; Karen L Fink; Larry Junck; David Schiff; Lauren E Abrey; Mark R Gilbert; Frank S Lieberman; John Kuhn; Lisa De Angelis; Minesh Mehta; Jeffrey J Raizer; W K Alfred Yung; Kenneth Aldape; John Wright; Kathleen R Lamborn; Michael D Prados
Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(22):3651-6.
2006: Wei Chen; Daniel H S Silverman; Sibylle Delaloye; Johannes Czernin; Nirav Kamdar; Whitney B Pope; Nagichettiar Satyamurthy; Christiaan Schiepers; Timothy F Cloughesy
18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):904-11.
2006: Paul S Mischel; Timothy F Cloughesy
Using molecular information to guide brain tumor therapy.
Nature clinical practice. Neurology 2006;2(5):232-3.
2006: Whitney B Pope; Albert Lai; P Nghiemphu; Paul S Mischel; Timothy F Cloughesy
MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy.
Neurology 2006;66(8):1258-60.
2006: Michael D Prados; Kathleen R Lamborn; W K Alfred Yung; Kurt A Jaeckle; H Ian Robins; Minesh Mehta; Howard A Fine; Patrick Y Wen; Timothy F Cloughesy; Susan Chang; M Kelly Nicholas; David Schiff; Harry S Greenberg; Larry Junck; Karen Fink; Kenneth Hess; John Kuhn
A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study.
Neuro-oncology 2006;8(2):189-93.
2006: Cho-Lea Tso; William A Freije; Allen Day; Zugen Chen; Barry Merriman; Ally Perlina; Yohan Lee; Ederlyn Q Dia; Koji Yoshimoto; Paul S Mischel; Linda M Liau; Timothy F Cloughesy; Stanley F Nelson
Distinct transcription profiles of primary and secondary glioblastoma subgroups.
Cancer research 2006;66(1):159-67.
2005: Ingo K Mellinghoff; Maria Y Wang; Igor Vivanco; Daphne A Haas-Kogan; Shaojun Zhu; Ederlyn Q Dia; Kan V Lu; Koji Yoshimoto; Julie H Y Huang; Dennis J Chute; Bridget L Riggs; Steve Horvath; Linda M Liau; Webster K Cavenee; P Nagesh Rao; Rameen Beroukhim; Timothy C Peck; Jeffrey C Lee; William R Sellers; David Stokoe; Michael Prados; Timothy F Cloughesy; Charles L Sawyers; Paul S Mischel
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
The New England journal of medicine 2005;353(19):2012-24.
2005: Whitney B Pope; James Sayre; Alla Perlina; J Pablo Villablanca; Paul S Mischel; Timothy F Cloughesy
MR imaging correlates of survival in patients with high-grade gliomas.
AJNR. American journal of neuroradiology 2005;26(10):2466-74.
2005: Timothy F Cloughesy; John Kuhn; H Ian Robins; Lauren E Abrey; Patrick Y Wen; Karen Fink; Frank S Lieberman; Minesh Mehta; Susan Chang; Alfred Yung; Lisa De Angelis; David Schiff; Larry Junck; Morris Groves; Steve Paquette; John Wright; Kathleen R Lamborn; Said M Sebti; Michael Prados
Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6647-56.
2005: Linda M Liau; Robert M Prins; Sylvia M Kiertscher; Sylvia K Odesa; Thomas J Kremen; Adrian J Giovannone; Jia-Wei Lin; Dennis J Chute; Paul S Mischel; Timothy F Cloughesy; Michael D Roth
Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5515-25.
2005: Susan M Chang; Patrick Y Wen; Timothy F Cloughesy; Harry S Greenberg; David Schiff; Charles Conrad; Karen Fink; H Ian Robins; Lisa De Angelis; Jeffrey J Raizer; Kenneth Hess; Kenneth Aldape; Kathleen R Lamborn; John Kuhn; Janet Dancey; Michael D Prados
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.
Investigational new drugs 2005;23(4):357-61.
2005: Kan V Lu; Kimberly A Jong; Gloria Y Kim; Jatinder Singh; Ederlyn Q Dia; Koji Yoshimoto; Maria Y Wang; Timothy F Cloughesy; Stanley F Nelson; Paul S Mischel
Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.
The Journal of biological chemistry 2005;280(29):26953-64.
2005: Wei Chen; Timothy F Cloughesy; Nirav Kamdar; Nagichettiar Satyamurthy; Marvin Bergsneider; Linda M Liau; Paul S Mischel; Johannes Czernin; Michael E Phelps; Daniel H S Silverman
Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(6):945-52.
2005: Ruty Mehrian-Shai; Juergen K V Reichardt; Hsu Ya-Hsuan; Thomas J Kremen; Linda M Liau; Timothy F Cloughesy; Paul S Mischel; Stanley F Nelson
Robustness of gene expression profiling in glioma specimen samplings and derived cell lines.
Brain research. Molecular brain research 2005;136(1-2):99-103.
2004: Joshua A Bryant; Richard S Finn; Dennis J Slamon; Timothy F Cloughesy; Andrew C Charles
EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells.
Cancer biology & therapy 2004;3(12):1243-9.
2004: Carrie Anne Graham; Timothy F Cloughesy
Brain tumor treatment: chemotherapy and other new developments.
Seminars in oncology nursing 2004;20(4):260-72.
2004: Vinay K Puduvalli; W K Alfred Yung; Kenneth R Hess; John Kuhn; Morris D Groves; Victor Levin; James Zwiebel; Susan M Chang; Timothy F Cloughesy; Larry Junck; Patrick Y Wen; Frank S Lieberman; Charles A Conrad; Mark R Gilbert; Christina A Meyers; Vivien Liu; Minesh Mehta; M Kelly Nicholas; Michael Prados
Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(21):4282-9.
2004: Susan M Chang; John Kuhn; Patrick Y Wen; Harry S Greenberg; David Schiff; Charles Conrad; Karen Fink; H Ian Robins; Timothy F Cloughesy; Lisa De Angelis; Jeffrey Razier; Kenneth Hess; Janet Dancey; Michael D Prados
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs.
Investigational new drugs 2004;22(4):427-35.
2004: Paul S Mischel; Timothy F Cloughesy; Stanley F Nelson
DNA-microarray analysis of brain cancer: molecular classification for therapy.
Nature reviews. Neuroscience 2004;5(10):782-92.
2004: William A Freije; F Edmundo Castro-Vargas; Zixing Fang; Steve Horvath; Timothy F Cloughesy; Linda M Liau; Paul S Mischel; Stanley F Nelson
Gene expression profiling of gliomas strongly predicts survival.
Cancer research 2004;64(18):6503-10.
2004: Thomas A Kaleita; David K Wellisch; Timothy F Cloughesy; Judith M Ford; Donald Freeman; Thomas R Belin; Jeffrey Goldman
Prediction of neurocognitive outcome in adult brain tumor patients.
Journal of neuro-oncology 2004;67(1-2):245-53.
2004: Yinglin Wang; Shaojun Zhu; Timothy F Cloughesy; Linda M Liau; Paul S Mischel
p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition.
Oncogene 2004;23(6):1283-90.
2004: Ricardo J Parker; John P Fruehauf; Rita Mehta; Emese Filka; Timothy F Cloughesy
A prospective blinded study of the predictive value of an extreme drug resistance assay in patients receiving CPT-11 for recurrent glioma.
Journal of neuro-oncology 2004;66(3):365-75.
2004: Michael D Prados; W K Alfred Yung; Kurt A Jaeckle; H Ian Robins; Minesh Mehta; Howard A Fine; Patrick Y Wen; Timothy F Cloughesy; Susan M Chang; M Kelly Nicholas; David Schiff; Harry S Greenberg; Larry Junck; Karen L Fink; Kenneth R Hess; John Kuhn
Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study.
Neuro-oncology 2004;6(1):44-54.
2004: Kan V Lu; Kimberly A Jong; Ayyappan K Rajasekaran; Timothy F Cloughesy; Paul S Mischel
Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line.
Laboratory investigation; a journal of technical methods and pathology 2004;84(1):8-20.
2003: Paul D. Brown; John T Wald; Mike W McDermott; Glen S Baumann; Timothy F Cloughesy
Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma.
Radiographics : a review publication of the Radiological Society of North America, Inc 2003;23(6):1591-611.
2003: Paul D. Brown; John T Wald; Mike W McDermott; Glen S Baumann; Timothy F Cloughesy
Oncodiagnosis panel: 2002. Primary glial neoplasm or less likely an intracranial abscess.
Radiographics : a review publication of the Radiological Society of North America, Inc 2003;23(6):1591-611.
2003: Paul D. Brown; John T Wald; Mike W McDermott; Glen S Baumann; Timothy F Cloughesy
Oncodiagnosis panel: 2002. Patient's symptoms not related to the lesion seen in the MR images.
Radiographics : a review publication of the Radiological Society of North America, Inc 2003;23(6):1591-611.
2003: Paul D. Brown; John T Wald; Mike W McDermott; Glen S Baumann; Timothy F Cloughesy
Oncodiagnosis panel: 2002. Metastatic NSCLC.
Radiographics : a review publication of the Radiological Society of North America, Inc 2003;23(6):1591-611.
2003: Ruty Shai; Tao Shi; Thomas J Kremen; Steve Horvath; Linda M Liau; Timothy F Cloughesy; Paul S Mischel; Stanley F Nelson
Gene expression profiling identifies molecular subtypes of gliomas.
Oncogene 2003;22(31):4918-23.
2003: Kurt A Jaeckle; Kenneth R Hess; W K Alfred Yung; Harry S Greenberg; Howard A Fine; David Schiff; Ian F Pollack; John Kuhn; Karen Fink; Minesh Mehta; Timothy F Cloughesy; M Kelly Nicholas; Susan Chang; Michael Prados
Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(12):2305-11.
2003: Gheeyoung Choe; Steve Horvath; Timothy F Cloughesy; Katherine Crosby; David Seligson; Aarno Palotie; Landon Inge; Bradley L Smith; Charles L Sawyers; Paul S Mischel
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.
Cancer research 2003;63(11):2742-6.
2003: Paul S Mischel; Stanley F Nelson; Timothy F Cloughesy
Molecular analysis of glioblastoma: pathway profiling and its implications for patient therapy.
Cancer biology & therapy 2003;2(3):242-7.
2003: Timothy F Cloughesy; Emese Filka; John Kuhn; Gillian Nelson; Fairooz Kabbinavar; Henry Friedman; Langdon L Miller; Gary L Elfring
Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen.
Cancer 2003;97(9 Suppl):2381-6.
2003: Paul S Mischel; Ruty Shai; Tao Shi; Steve Horvath; Kan V Lu; Gheeyoung Choe; David Seligson; Thomas J Kremen; Aarno Palotie; Linda M Liau; Timothy F Cloughesy; Stanley F Nelson
Identification of molecular subtypes of glioblastoma by gene expression profiling.
Oncogene 2003;22(15):2361-73.
2003: Paul S Mischel; Timothy F Cloughesy
Targeted molecular therapy of GBM.
Brain pathology (Zurich, Switzerland) 2003;13(1):52-61.
2002: Gheeyoung Choe; Jun K Park; Lisa Jouben-Steele; Thomas J Kremen; Linda M Liau; Harry V Vinters; Timothy F Cloughesy; Paul S Mischel
Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(9):2894-901.
2002: Jeffry R Alger; Andrew J Frew; Timothy F Cloughesy; Walter Del Vecchio; J Pablo Villablanca; John G Curran
Novel methodology for the archiving and interactive reading of clinical magnetic resonance spectroscopic imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;48(3):411-8.
2002: David K Wellisch; Thomas A Kaleita; Donald Freeman; Timothy F Cloughesy; Jeffrey Goldman
Predicting major depression in brain tumor patients.
Psycho-oncology 2002;11(3):230-8.
2002: Timothy F Cloughesy; Emese Filka; Gillian Nelson; Fairooz Kabbinavar; Henry Friedman; Langdon L Miller; Gary L Elfring
Irinotecan treatment for recurrent malignant glioma using an every-3-week regimen.
American journal of clinical oncology 2002;25(2):204-8.
2002: H Ian Robins; Susan M Chang; Michael D Prados; W K Alfred Yung; Kenneth Hess; David Schiff; Harry S Greenberg; Karen Fink; Kelly Nicolas; John Kuhn; Timothy F Cloughesy; Larry Junck; Minesh Mehta
A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study.
Neuro-oncology 2002;4(2):109-14.
2001: S M Haney; Paul M Thompson; Timothy F Cloughesy; Jeffry R Alger; A J Frew; A Torres-Trejo; John C Mazziotta; Arthur W Toga
Mapping therapeutic response in a patient with malignant glioma.
Journal of computer assisted tomography 2001;25(4):529-36.
2001: Yves Gobin; Timothy F Cloughesy; K L Chow; Gary R Duckwiler; James W Sayre; K Milanese; Fernando Viñuela
Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery.
Radiology 2001;218(3):724-32.
2001: S M Haney; P M Thompson; Timothy F Cloughesy; Jeffry R Alger; Arthur W Toga
Tracking tumor growth rates in patients with malignant gliomas: a test of two algorithms.
AJNR. American journal of neuroradiology 2001;22(1):73-82.
2000: R K Gupta; Timothy F Cloughesy; Usha Sinha; Justine Garakian; Jorge A Lazareff; Gregory Rubino; Louis Rubino; Donald P Becker; Harry V Vinters; Jeffry R Alger
Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma.
Journal of neuro-oncology 2000;50(3):215-26.
2000: K L Chow; Yves Gobin; Timothy F Cloughesy; James W Sayre; J P Villablanca; Fernando Viñuela
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy.
AJNR. American journal of neuroradiology 2000;21(3):471-8.
1999: Linda M Liau; K L Black; Robert M Prins; Steven N Sykes; P L DiPatre; Timothy F Cloughesy; Donald P Becker; Jeff M Bronstein
Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens.
Journal of neurosurgery 1999;90(6):1115-24.
1999: Timothy F Cloughesy; KL Black; Yves Gobin; Keyvan Farahani; G Nelson; Pablo Villablanca; Fairooz Kabbinavar; F Viñeula; C H Wortel
Intra-arterial Cereport (RMP-7) and carboplatin: a dose escalation study for recurrent malignant gliomas.
Neurosurgery 1999;44(2):270-8; discussion 278-9.
1999: R K Gupta; Usha Sinha; Timothy F Cloughesy; Jeffry R Alger
Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(1):2-7.
1998: Andrew F Cannestra; K L Black; Neil A Martin; Timothy F Cloughesy; J S Burton; E Rubinstein; Roger P Woods; Arthur W Toga
Topographical and temporal specificity of human intraoperative optical intrinsic signals.
Neuroreport 1998;9(11):2557-63.
1997: Timothy F Cloughesy; Yves Gobin; KL Black; Fernando Viñuela; F Taft; B Kadkhoda; Fairooz Kabbinavar
Intra-arterial carboplatin chemotherapy for brain tumors: a dose escalation study based on cerebral blood flow.
Journal of neuro-oncology 1997;35(2):121-31.
1997: Timothy F Cloughesy; Roger P Woods; KL Black; W T Couldwell; R E Law; D R Hinton
Prolonged treatment with biologic agents for malignant glioma: a case study with high dose tamoxifen.
Journal of neuro-oncology 1997;35(1):39-45.
1997: KL Black; Timothy F Cloughesy; S C Huang; Yves Gobin; Y Zhou; J Grous; G Nelson; Keyvan Farahani; Carl K Hoh; Michael Phelps
Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas.
Journal of neurosurgery 1997;86(4):603-9.
1995: Timothy F Cloughesy; K L Black
Pharmacological blood-brain barrier modification for selective drug delivery.
Journal of neuro-oncology 1995;26(2):125-32.
1995: Daniel Geschwind; Marco Iacoboni; Michael S Mega; Dahlia W Zaidel; Timothy F Cloughesy; Eran Zaidel
Alien hand syndrome: interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum.
Neurology 1995;45(4):802-8.
1993: Robert W Baloh; S E DeRossett; Timothy F Cloughesy; R W Kuncl; Neil R Miller; J Merrill; Jerome B Posner
Novel brainstem syndrome associated with prostate carcinoma.
Neurology 1993;43(12):2591-6.
1993: Timothy F Cloughesy; Marc R Nuwer; D Hoch; Fernando Vinuela; Gary R Duckwiler; Neil Martin
Monitoring carotid test occlusions with continuous EEG and clinical examination.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 1993;10(3):363-9.
1992: Marc R Nuwer; W R Banoczi; Timothy F Cloughesy; D B Hoch; W Peacock; michel levesque; K L Black; Neil A Martin; Donald P Becker
Topographic mapping of somatosensory evoked potentials helps identify motor cortex more quickly in the operating room.
Brain topography 1992;5(1):53-8.