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Alexander Clowes

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Kathleen R Braun; Steven L Bressler; Lihua Chen; Alexander W Clowes; Allison M DeWispelaere; Nozomi Fukai; Richard D Kenagy; Michael G Kinsella
Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.
Priya Handa; Alan Chait; Andrew M Cheng; Alexander W Clowes; Guenter Daum; Chang Yeop Han; Vicki Morgan-Stevenson; Kevin D O'Brien; Norma O Rizzo; Michael W Schwartz; Sanshiro Tateya; Francis Kim
Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding.
Richard D Kenagy; Seung-Kee Min; Eileen R Mulvihill; Alexander W Clowes
A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.

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2012: Kathleen R Braun; Steven L Bressler; Lihua Chen; Alexander W Clowes; Allison M DeWispelaere; Nozomi Fukai; Richard D Kenagy; Michael G Kinsella
Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.
PloS one 2012;7(8):e43701.
2011: Priya Handa; Alan Chait; Andrew M Cheng; Alexander W Clowes; Guenter Daum; Chang Yeop Han; Vicki Morgan-Stevenson; Kevin D O'Brien; Norma O Rizzo; Michael W Schwartz; Sanshiro Tateya; Francis Kim
Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2827-35.
2011: Richard D Kenagy; Seung-Kee Min; Eileen R Mulvihill; Alexander W Clowes
A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.
Journal of vascular surgery 2011;54(1):182-191.e24.
2010: Olivier D Defawe; Sarah Kim; Lihua Chen; Daming Huang; Richard D Kenagy; Thomas Renné; Ulrich Walter; Günter Daum; Alexander W Clowes
VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen.
Journal of cellular physiology 2010;222(1):230-7.
2009: Nozomi Fukai; Richard D Kenagy; Lihua Chen; Lu Gao; Günter Daum; Alexander W Clowes
Syndecan-1: an inhibitor of arterial smooth muscle cell growth and intimal hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1356-62.
2009: Richard D Kenagy; Seung-Kee Min; Alexander W Clowes; John D Sandy
Cell death-associated ADAMTS4 and versican degradation in vascular tissue.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(9):889-97.
2009: Richard D Kenagy; Nozomi Fukai; Seung-Kee Min; Florencia Jalikis; Ted R Kohler; Alexander W Clowes
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
Journal of vascular surgery 2009;49(5):1282-8.
2009: Louis L Nguyen; Nathanael Hevelone; Selwyn O Rogers; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Stuart R Lipsitz; Michael S Conte
Disparity in outcomes of surgical revascularization for limb salvage: race and gender are synergistic determinants of vein graft failure and limb loss.
Circulation 2009;119(1):123-30.
2008: Jin-Yong Hwang; Pamela Y Johnson; Kathleen R Braun; Aleksander Hinek; Jens W Fischer; Kevin D O'Brien; Barry Starcher; Alexander W Clowes; Mervyn J Merrilees; Thomas N Wight
Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury.
The American journal of pathology 2008;173(6):1919-28.
2008: William H Pearce; John A Mannick; Alexander W Clowes; James S T Yao
Twentieth anniversary of American Vascular Association/Lifeline Foundation: a celebration.
Journal of vascular surgery 2008;47(6):1351-5.
2008: Seog-Ki Min; Richard D Kenagy; Joseph P Jeanette; Alexander W Clowes
Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery.
Journal of vascular surgery 2008;47(5):1039-47.
2008: Seung-Kee Min; Richard D Kenagy; Alexander W Clowes
Induction of vascular atrophy as a novel approach to treating restenosis. A review.
Journal of vascular surgery 2008;47(3):662-70.
2007: Louis L Nguyen; Soma Brahmanandam; Dennis F Bandyk; Michael Belkin; Alexander W Clowes; Gregory L Moneta; Michael S Conte
Female gender and oral anticoagulants are associated with wound complications in lower extremity vein bypass: an analysis of 1404 operations for critical limb ischemia.
Journal of vascular surgery 2007;46(6):1191-1197.
2007: Andres Schanzer; Nathanael Hevelone; Christopher D Owens; Michael Belkin; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Michael S Conte
Technical factors affecting autogenous vein graft failure: observations from a large multicenter trial.
Journal of vascular surgery 2007;46(6):1180-90; discussion 1190.
2007: Scott A Berceli; Nathanael Hevelone; Stuart R Lipsitz; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Michael S Conte
Surgical and endovascular revision of infrainguinal vein bypass grafts: analysis of midterm outcomes from the PREVENT III trial.
Journal of vascular surgery 2007;46(6):1173-1179.
2007: Robert W Thompson; Beth Schucker; K Kent; Alexander W Clowes; Larry W Kraiss; John A Mannick; James S T Yao
Reviving the vascular surgeon-scientist: an interim assessment of the jointly sponsored Lifeline Foundation/National Heart, Lung, and Blood Institute William J. von Liebig Mentored Clinical Scientist Development (K08) Program.
Journal of vascular surgery 2007;45 Suppl A():A2-7.
2006: Louis L Nguyen; Gregory L Moneta; Michael S Conte; Dennis F Bandyk; Alexander W Clowes; B Lynn Seely
Prospective multicenter study of quality of life before and after lower extremity vein bypass in 1404 patients with critical limb ischemia.
Journal of vascular surgery 2006;44(5):977-83; discussion 983-4.
2006: Louis L Nguyen; Stuart R Lipsitz; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Michael Belkin; Michael S Conte
Resource utilization in the treatment of critical limb ischemia: The effect of tissue loss, comorbidities, and graft-related events.
Journal of vascular surgery 2006;44(5):971-5; discussion 975-6.
2006: Shyam Krishnan; Alexander W Clowes
Dacron patch infection after carotid endarterectomy: case report and review of the literature.
Annals of vascular surgery 2006;20(5):672-7.
2006: Michael S Conte; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Lynn Seely; Todd J Lorenz; Hamid Namini; Allen D Hamdan; Sean P Roddy; Michael Belkin; Scott A Berceli; Richard J DeMasi; Russell H Samson; Scott S Berman
Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery.
Journal of vascular surgery 2006;43(4):742-751; discussion 751.
2006: Baocheng Chu; Chun Yuan; Norihide Takaya; Jason R Shewchuk; Alexander W Clowes; Thomas S Hatsukami
Images in cardiovascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaque.
Circulation 2006;113(12):e660-1.
2006: Robert Huang; Mervyn J Merrilees; Kathleen Braun; Brent W Beaumont; Joan M Lemire; Alexander W Clowes; Aleksander Hinek; Thomas N Wight
Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury.
Circulation research 2006;98(3):370-7.
2006: Patrick C H Hsieh; Richard D Kenagy; Eileen R Mulvihill; Joseph P Jeanette; Xi Wang; Cindy M C Chang; Zizhen Yao; Walter L Ruzzo; Suzanne Justice; Kelly Hudkins; Charles E Alpers; Scott A Berceli; Alexander W Clowes
Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy.
Journal of vascular surgery 2006;43(1):150-8.
2006: Esther Millette; Bernhard H Rauch; Richard D Kenagy; Günter Daum; Alexander W Clowes
Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells.
Trends in cardiovascular medicine 2006;16(1):25-8.
2005: Michael S Conte; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; Hamid Namini; Lynn Seely
Risk factors, medical therapies and perioperative events in limb salvage surgery: observations from the PREVENT III multicenter trial.
Journal of vascular surgery 2005;42(3):456-64; discussion 464-5.
2005: Olivier D Defawe; Richard D Kenagy; Chun Choi; Samuel Y C Wan; Christophe Deroanne; Betty Nusgens; Natzi Sakalihasan; Alain Colige; Alexander W Clowes
MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9.
Cardiovascular research 2005;66(2):402-9.
2005: Bernhard H Rauch; Esther Millette; Richard D Kenagy; Günter Daum; Jens W Fischer; Alexander W Clowes
Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells.
The Journal of biological chemistry 2005;280(17):17507-11.
2005: Alexander W Clowes
Commentary. Circulating monocytes and in-stent neointima after coronary stent implantation.
Perspectives in vascular surgery and endovascular therapy 2005;17(1):60-2.
2005: Esther Millette; Bernhard H Rauch; Olivier D Defawe; Richard D Kenagy; Günter Daum; Alexander W Clowes
Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.
Circulation research 2005;96(2):172-9.
2005: Michael S Conte; Todd J Lorenz; Dennis F Bandyk; Alexander W Clowes; Gregory L Moneta; B Lynn Seely
Design and rationale of the PREVENT III clinical trial: edifoligide for the prevention of infrainguinal vein graft failure.
Vascular and endovascular surgery 2005;39(1):15-23.
2005: Richard D Kenagy; Jens W Fischer; Stephanie L Lara; John D Sandy; Alexander W Clowes; Thomas N Wight
Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(1):131-40.
2004: Lihua Chen; Günter Daum; Kanchan Chitaley; Scott A Coats; Daniel F Bowen-Pope; Martin Eigenthaler; Thumati Naresh; Ulrich Walter; Alexander W Clowes
Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1403-8.
2004: Jens W Fischer; Suzanne Hawkins; Alexander W Clowes
Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries.
Journal of vascular surgery 2004;40(1):115-22.
2004: Michael J Englesbe; Mark G Davies; Suzanne M Hawkins; Patrick C H Hsieh; Günter Daum; Richard D Kenagy; Alexander W Clowes
Arterial injury repair in nonhuman primates-the role of PDGF receptor-beta.
The Journal of surgical research 2004;119(1):80-4.
2004: Michael J Englesbe; Jessie Deou; Brenda D Bourns; Alexander W Clowes; Günter Daum
Interleukin-1beta inhibits PDGF-BB-induced migration by cooperating with PDGF-BB to induce cyclooxygenase-2 expression in baboon aortic smooth muscle cells.
Journal of vascular surgery 2004;39(5):1091-6.
2004: Tomoko Shofuda; Ken-ichi Shofuda; Nicola Ferri; Richard D Kenagy; Elaine W Raines; Alexander W Clowes
Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(5):839-44.
2004: Bernhard H Rauch; Esther Millette; Richard D Kenagy; Günter Daum; Alexander W Clowes
Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.
Circulation research 2004;94(3):340-5.
2004: Michael J Englesbe; Suzanne M Hawkins; Patrick C H Hsieh; Günter Daum; Richard D Kenagy; Alexander W Clowes
Concomitant blockade of platelet-derived growth factor receptors alpha and beta induces intimal atrophy in baboon PTFE grafts.
Journal of vascular surgery 2004;39(2):440-6.
2004: Kanchan Chitaley; L Chen; A Galler; U Walter; Günter Daum; Alexander W Clowes
Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C.
FEBS letters 2004;556(1-3):211-5.
2003: Allen K Chan; Andreas Kalmes; Suzanne Hawkins; Günter Daum; Alexander W Clowes
Blockade of the epidermal growth factor receptor decreases intimal hyperplasia in balloon-injured rat carotid artery.
Journal of vascular surgery 2003;37(3):644-9.
2003: Michael J Englesbe; Audrey H Wu; Alexander W Clowes; R Eugene Zierler
The prevalence and natural history of aortic aneurysms in heart and abdominal organ transplant patients.
Journal of vascular surgery 2003;37(1):27-31.
2002: Bodo Levkau; Richard D Kenagy; Aly Karsan; B Weitkamp; Alexander W Clowes; Russell Ross; Elaine W Raines
Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells.
Cell death and differentiation 2002;9(12):1360-7.
2002: Scott A Berceli; Mark G Davies; Richard D Kenagy; Alexander W Clowes
Flow-induced neointimal regression in baboon polytetrafluoroethylene grafts is associated with decreased cell proliferation and increased apoptosis.
Journal of vascular surgery 2002;36(6):1248-55.
2002: Tyler J Nathe; Jessie Deou; Bethany Walsh; Brenda Bourns; Alexander W Clowes; Günter Daum
Interleukin-1beta inhibits expression of p21(WAF1/CIP1) and p27(KIP1) and enhances proliferation in response to platelet-derived growth factor-BB in smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1293-8.
2002: Richard D Kenagy; BR Vesti; Alexander W Clowes
The urokinase receptor mediates basic fibroblast growth factor-dependent smooth muscle cell migration through baboon aortic explants.
Atherosclerosis 2002;162(1):63-7.
2002: Mervyn J Merrilees; Joan M Lemire; Jens W Fischer; Michael G Kinsella; Kathleen R Braun; Alexander W Clowes; Thomas N Wight
Retrovirally mediated overexpression of versican v3 by arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointima after vascular injury.
Circulation research 2002;90(4):481-7.
2002: Richard D Kenagy; Jens W Fischer; Mark G Davies; Scott A Berceli; Suzanne M Hawkins; Thomas N Wight; Alexander W Clowes
Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):400-4.
2001: Andreas Kalmes; Günter Daum; Alexander W Clowes
EGFR transactivation in the regulation of SMC function.
Annals of the New York Academy of Sciences 2001;947():42-54; discussion 54-5.
2001: Ken-ichi Shofuda; D Hasenstab; Tomoko Shofuda; Richard D Kenagy; Alexander W Clowes
Control of smooth muscle cell function by membrane-type matrix metalloproteinases.
Annals of the New York Academy of Sciences 2001;947():337-40.
2001: S Lepidi; Richard D Kenagy; Elaine W Raines; E S Chiu; Alan Chait; Russell Ross; Alexander W Clowes
MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen.
Journal of vascular surgery 2001;34(6):1111-8.
2001: Ken-ichi Shofuda; D Hasenstab; Richard D Kenagy; Tomoko Shofuda; Zong-Yi Li; André Lieber; Alexander W Clowes
Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2010-2.
2001: Karin Lundmark; Phan-Kiet Tran; Michael G Kinsella; Alexander W Clowes; Thomas N Wight; Ulf Hedin
Perlecan inhibits smooth muscle cell adhesion to fibronectin: role of heparan sulfate.
Journal of cellular physiology 2001;188(1):67-74.
2001: Marie-Luce Bochaton-Piallat; Alexander W Clowes; MM Clowes; Jens W Fischer; M Redard; F Gabbiani; Giulio Gabbiani
Cultured arterial smooth muscle cells maintain distinct phenotypes when implanted into carotid artery.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(6):949-54.
2001: Jens W Fischer; Michael G Kinsella; Bodo Levkau; Alexander W Clowes; Thomas N Wight
Retroviral overexpression of decorin differentially affects the response of arterial smooth muscle cells to growth factors.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):777-84.
2001: John D Sandy; Jennifer Westling; Richard D Kenagy; M Luisa Iruela-Arispe; C Verscharen; J C Rodriguez-Mazaneque; D R Zimmermann; Joan M Lemire; Jens W Fischer; Thomas N Wight; Alexander W Clowes
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
The Journal of biological chemistry 2001;276(16):13372-8.
2001: Mark G Davies; DP Mason; Phan-Kiet Tran; Jessie Deou; Suzanne Hawkins; Alexander W Clowes
G-protein expression and intimal hyperplasia after arterial injury: a role for Galpha(i) proteins.
Journal of vascular surgery 2001;33(2):408-18.
2001: Jens W Fischer; Michael G Kinsella; D Hasenstab; Alexander W Clowes; Thomas N Wight
Cell-mediated transfer of proteoglycan genes.
Methods in molecular biology (Clifton, N.J.) 2001;171():261-9.
2000: Richard D Kenagy; Alexander W Clowes
Blockade of smooth muscle cell migration and proliferation in baboon aortic explants by interleukin-1beta and tumor necrosis factor-alpha is nitric oxide-dependent and nitric oxide-independent.
Journal of vascular research 2000;37(5):381-9.
2000: Andreas Kalmes; BR Vesti; Günter Daum; J A Abraham; Alexander W Clowes
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
Circulation research 2000;87(2):92-8.
2000: D Hasenstab; H Lea; CE Hart; S Lok; Alexander W Clowes
Tissue factor overexpression in rat arterial neointima models thrombosis and progression of advanced atherosclerosis.
Circulation 2000;101(22):2651-7.
2000: Alexander W Clowes; Scott A Berceli
Mechanisms of vascular atrophy and fibrous cap disruption.
Annals of the New York Academy of Sciences 2000;902():153-61; discussion 161-2.
2000: Mark G Davies; E L Owens; DP Mason; H Lea; Phan-Kiet Tran; SM Vergel; S A Hawkins; CE Hart; Alexander W Clowes
Effect of platelet-derived growth factor receptor-alpha and -beta blockade on flow-induced neointimal formation in endothelialized baboon vascular grafts.
Circulation research 2000;86(7):779-86.
2000: Jens W Fischer; Michael G Kinsella; MM Clowes; Stephanie L Lara; Alexander W Clowes; Thomas N Wight
Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats.
Circulation research 2000;86(6):676-83.
2000: L Chen; Günter Daum; Jens W Fischer; Suzanne Hawkins; Marie-Luce Bochaton-Piallat; G Gabbiani; Alexander W Clowes
Loss of expression of the beta subunit of soluble guanylyl cyclase prevents nitric oxide-mediated inhibition of DNA synthesis in smooth muscle cells of old rats.
Circulation research 2000;86(5):520-5.
2000: D Hasenstab; H Lea; Alexander W Clowes
Local plasminogen activator inhibitor type 1 overexpression in rat carotid artery enhances thrombosis and endothelial regeneration while inhibiting intimal thickening.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):853-9.
1999: DP Mason; Richard D Kenagy; D Hasenstab; Daniel F Bowen-Pope; Ronald A Seifert; Stephen R Coats; Suzanne M Hawkins; Alexander W Clowes
Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery.
Circulation research 1999;85(12):1179-85.
1999: Andreas Kalmes; Jessie Deou; Alexander W Clowes; Günter Daum
Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580.
FEBS letters 1999;444(1):71-4.
1999: CE Hart; Larry W Kraiss; SM Vergel; Debra G Gilbertson; Richard D Kenagy; T Kirkman; D L Crandall; S Tickle; H Finney; G Yarranton; Alexander W Clowes
PDGFbeta receptor blockade inhibits intimal hyperplasia in the baboon.
Circulation 1999;99(4):564-9.
1999: Alexander W Clowes
Regulation of smooth muscle cell proliferation and migration.
Transplantation proceedings 1999;31(1-2):810-1.
1998: E Allaire; R Forough; MM Clowes; B Starcher; Alexander W Clowes
Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model.
The Journal of clinical investigation 1998;102(7):1413-20.
1998: E J Mattsson; R L Geary; Larry W Kraiss; SM Vergel; J K Liao; M A Corson; Y P Au; Stephen R Hanson; Alexander W Clowes
Is smooth muscle growth in primate arteries regulated by endothelial nitric oxide synthase?
Journal of vascular surgery 1998;28(3):514-21.
1998: N Koyama; Michael G Kinsella; Thomas N Wight; Ulf Hedin; Alexander W Clowes
Heparan sulfate proteoglycans mediate a potent inhibitory signal for migration of vascular smooth muscle cells.
Circulation research 1998;83(3):305-13.
1998: E Allaire; D Hasenstab; Richard D Kenagy; B Starcher; MM Clowes; Alexander W Clowes
Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1.
Circulation 1998;98(3):249-55.
1998: Günter Daum; B Levkau; N L Chamberlain; Y Wang; Alexander W Clowes
The mitogen-activated protein kinase pathway contributes to vanadate toxicity in vascular smooth muscle cells.
Molecular and cellular biochemistry 1998;183(1-2):97-103.
1998: Günter Daum; Andreas Kalmes; B Levkau; Y Wang; Mark G Davies; Alexander W Clowes
Pervanadate inhibits mitogen-activated protein kinase kinase-1 in a p38MAPK-dependent manner.
FEBS letters 1998;427(2):271-4.
1998: L Chen; Günter Daum; R Forough; MM Clowes; U Walter; Alexander W Clowes
Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery.
Circulation research 1998;82(8):862-70.
1998: R Forough; H Lea; B Starcher; E Allaire; MM Clowes; D Hasenstab; Alexander W Clowes
Metalloproteinase blockade by local overexpression of TIMP-1 increases elastin accumulation in rat carotid artery intima.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(5):803-7.
1998: Ulf Hedin; Günter Daum; Alexander W Clowes
Heparin inhibits thrombin-induced mitogen-activated protein kinase signaling in arterial smooth muscle cells.
Journal of vascular surgery 1998;27(3):512-20.
1997: Richard D Kenagy; CE Hart; William Stetler-Stevenson; Alexander W Clowes
Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9.
Circulation 1997;96(10):3555-60.
1997: E J Mattsson; Ted R Kohler; SM Vergel; Alexander W Clowes
Increased blood flow induces regression of intimal hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):2245-9.
1997: Sean Lille; Günter Daum; MM Clowes; Alexander W Clowes
The regulation of p42/p44 mitogen-activated protein kinases in the injured rat carotid artery.
The Journal of surgical research 1997;70(2):178-86.
1997: Ulf Hedin; Günter Daum; Alexander W Clowes
Disruption of integrin alpha 5 beta 1 signaling does not impair PDGF-BB-mediated stimulation of the extracellular signal-regulated kinase pathway in smooth muscle cells.
Journal of cellular physiology 1997;172(1):109-16.
1997: Günter Daum; Ulf Hedin; Y Wang; T Wang; Alexander W Clowes
Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells.
Circulation research 1997;81(1):17-23.
1997: Alexander W Clowes
Vascular gene transfer using smooth muscle cells.
Annals of the New York Academy of Sciences 1997;811():293-7; discussion 297-8.
1997: D Hasenstab; R Forough; Alexander W Clowes
Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinases-2 increase after arterial injury in rats.
Circulation research 1997;80(4):490-6.
1997: CE Hart; Alexander W Clowes
Platelet-derived growth factor and arterial response to injury.
Circulation 1997;95(3):555-6.
1996: Denis deBlois; DM Lombardi; Enming Joseph Su; Alexander W Clowes; Stephen M Schwartz; Cecilia M Giachelli
Angiotensin II induction of osteopontin expression and DNA replication in rat arteries.
Hypertension 1996;28(6):1055-63.
1996: Richard D Kenagy; SM Vergel; E Mattsson; M Bendeck; Michael A Reidy; Alexander W Clowes
The role of plasminogen, plasminogen activators, and matrix metalloproteinases in primate arterial smooth muscle cell migration.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(11):1373-82.
1996: Jean-Marc Herbert; M Clowes; H J Lea; M Pascal; Alexander W Clowes
Protein kinase C alpha expression is required for heparin inhibition of rat smooth muscle cell proliferation in vitro and in vivo.
The Journal of biological chemistry 1996;271(42):25928-35.
1996: R Forough; N Koyama; D Hasenstab; H Lea; MM Clowes; S T Nikkari; Alexander W Clowes
Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo.
Circulation research 1996;79(4):812-20.
1996: Denis deBlois; M Viswanathan; Enming Joseph Su; Alexander W Clowes; J M Saavedra; Stephen M Schwartz
Smooth muscle DNA replication in response to angiotensin II is regulated differently in the neointima and media at different times after balloon injury in the rat carotid artery. Role of AT1 receptor expression.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(9):1130-7.
1996: Larry W Kraiss; Randolph L Geary; E J Mattsson; SM Vergel; Y P Au; Alexander W Clowes
Acute reductions in blood flow and shear stress induce platelet-derived growth factor-A expression in baboon prosthetic grafts.
Circulation research 1996;79(1):45-53.
1996: R Forough; D Hasenstab; N Koyama; H Lea; MM Clowes; Alexander W Clowes
Generating antibodies against secreted proteins using vascular smooth muscle cells transduced with replication-defective retrovirus.
BioTechniques 1996;20(4):694-701.
1996: J Seki; N Koyama; N L Kovach; T Yednock; Alexander W Clowes; John M Harlan
Regulation of beta1-integrin function in cultured human vascular smooth muscle cells.
Circulation research 1996;78(4):596-605.
1996: S T Nikkari; Randolph L Geary; Thomas S Hatsukami; M Ferguson; R Forough; Charles E Alpers; Alexander W Clowes
Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy.
The American journal of pathology 1996;148(3):777-83.
1996: N Koyama; J Seki; SM Vergel; E J Mattsson; T Yednock; N L Kovach; John M Harlan; Alexander W Clowes
Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro.
The American journal of pathology 1996;148(3):749-61.
1996: F Frank Isik; S R Coughlin; Nicolas Nelken; Alexander W Clowes; David F Gordon
JE gene expression in an animal model of acute arterial graft rejection.
The Journal of surgical research 1996;60(1):224-31.
1996: N Zempo; N Koyama; Richard D Kenagy; H J Lea; Alexander W Clowes
Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(1):28-33.
1995: R Forough; S T Nikkari; D Hasenstab; H Lea; Alexander W Clowes
Cloning and characterization of a cDNA encoding the baboon tissue inhibitor of matrix metalloproteinase-1 (TIMP-1).
Gene 1995;163(2):267-71.
1995: S T Nikkari; Kevin D O'Brien; M Ferguson; Thomas S Hatsukami; H G Welgus; Charles E Alpers; Alexander W Clowes
Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis.
Circulation 1995;92(6):1393-8.
1995: E Mattsson; Alexander W Clowes
Current concepts in restenosis following balloon angioplasty.
Trends in cardiovascular medicine 1995;5(5):200-4.
1995: William R A Osborne; N Ramesh; S Lau; MM Clowes; D C Dale; Alexander W Clowes
Gene therapy for long-term expression of erythropoietin in rats.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8055-8.
1995: Randolph L Geary; N Koyama; T W Wang; SM Vergel; Alexander W Clowes
Failure of heparin to inhibit intimal hyperplasia in injured baboon arteries. The role of heparin-sensitive and -insensitive pathways in the stimulation of smooth muscle cell migration and proliferation.
Circulation 1995;91(12):2972-81.
1995: M H Wu; Qun Shi; AR Wechezak; Alexander W Clowes; I L Gordon; Lester R Sauvage
Definitive proof of endothelialization of a Dacron arterial prosthesis in a human being.
Journal of vascular surgery 1995;21(5):862-7.
1995: Richard D Kenagy; Alexander W Clowes
Regulation of baboon arterial smooth muscle cell plasminogen activators by heparin and growth factors.
Thrombosis research 1995;77(1):55-61.
1994: F Frank Isik; Alexander W Clowes; David F Gordon
Elastin expression in a model of acute arterial graft rejection.
Transplantation 1994;58(11):1246-51.
1994: Qun Shi; MH Wu; N Hayashida; AR Wechezak; Alexander W Clowes; Lester R Sauvage
Proof of fallout endothelialization of impervious Dacron grafts in the aorta and inferior vena cava of the dog.
Journal of vascular surgery 1994;20(4):546-56; discussion 556-7.
1994: N Koyama; CE Hart; Alexander W Clowes
Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells.
Circulation research 1994;75(4):682-91.
1994: Randolph L Geary; Alexander W Clowes; S Lau; SM Vergel; D C Dale; William R A Osborne
Gene transfer in baboons using prosthetic vascular grafts seeded with retrovirally transduced smooth muscle cells: a model for local and systemic gene therapy.
Human gene therapy 1994;5(10):1211-6.
1994: R Forough; D Hasenstab; N Zempo; K Langley; Y De Clerck; Alexander W Clowes
Induction of tissue inhibitor of metalloproteinase-2 in injured rat artery.
Annals of the New York Academy of Sciences 1994;732():384-8.
1994: Richard D Kenagy; Alexander W Clowes
A possible role for MMP-2 and MMP-9 in the migration of primate arterial smooth muscle cells through native matrix.
Annals of the New York Academy of Sciences 1994;732():462-5.
1994: M P Bendeck; N Zempo; Alexander W Clowes; R E Galardy; Michael A Reidy
Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat.
Circulation research 1994;75(3):539-45.
1994: N Zempo; Richard D Kenagy; Y P Au; M Bendeck; MM Clowes; Michael A Reidy; Alexander W Clowes
Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery.
Journal of vascular surgery 1994;20(2):209-17.
1994: Y P Au; G Dobrowolska; David R Morris; Alexander W Clowes
Heparin decreases activator protein-1 binding to DNA in part by posttranslational modification of Jun B.
Circulation research 1994;75(1):15-22.
1994: S T Nikkari; Hannu Järveläinen; Thomas N Wight; M Ferguson; Alexander W Clowes
Smooth muscle cell expression of extracellular matrix genes after arterial injury.
The American journal of pathology 1994;144(6):1348-56.
1994: Alexander W Clowes; Randolph L Geary
Kinmonth Memorial Lecture. Vascular Surgical Society of Great Britain and Northern Ireland. London, November 1992. Vascular biology--the new frontier.
Cardiovascular surgery (London, England) 1994;2(3):301-7.
1994: Richard D Kenagy; S T Nikkari; H G Welgus; Alexander W Clowes
Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells.
The Journal of clinical investigation 1994;93(5):1987-93.
1994: S T Nikkari; Alexander W Clowes
Restenosis after vascular reconstruction.
Annals of medicine 1994;26(2):95-100.
1994: MM Clowes; C M Lynch; A Dusty Miller; D G Miller; William R A Osborne; Alexander W Clowes
Long-term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes.
The Journal of clinical investigation 1994;93(2):644-51.
1994: Randolph L Geary; Ted R Kohler; SM Vergel; T R Kirkman; Alexander W Clowes
Time course of flow-induced smooth muscle cell proliferation and intimal thickening in endothelialized baboon vascular grafts.
Circulation research 1994;74(1):14-23.
1993: Larry W Kraiss; Elaine W Raines; Josiah N Wilcox; Ronald A Seifert; T B Barrett; T R Kirkman; CE Hart; Daniel F Bowen-Pope; Russell Ross; Alexander W Clowes
Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly.
The Journal of clinical investigation 1993;92(1):338-48.
1993: S Mutoh; MM Clowes; Alexander W Clowes
Heparin increased cell membrane-associated heparan sulfate proteoglycan in balloon-injured rat carotid artery.
Journal of vascular research 1993;30(3):161-8.
1993: Y P Au; Richard D Kenagy; MM Clowes; Alexander W Clowes
Mechanisms of inhibition by heparin of vascular smooth muscle cell proliferation and migration.
Haemostasis 1993;23 Suppl 1():177-82.
1992: J Fingerle; A Faulmüller; G Müller; D F Bowen-Pope; MM Clowes; Michael A Reidy; Alexander W Clowes
Pituitary factors in blood plasma are necessary for smooth muscle cell proliferation in response to injury in vivo.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(12):1488-95.
1992: Ted R Kohler; J R Stratton; T R Kirkman; K H Johansen; Brenda K Zierler; Alexander W Clowes
Conventional versus high-porosity polytetrafluoroethylene grafts: clinical evaluation.
Surgery 1992;112(5):901-7.
1992: V Lindner; NE Olson; Alexander W Clowes; Michael A Reidy
Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor.
The Journal of clinical investigation 1992;90(5):2044-9.
1992: Brenda K Zierler; T R Kirkman; Larry W Kraiss; W G Reiss; J R Horn; L A Bauer; Alexander W Clowes; Ted R Kohler
Accuracy of duplex scanning for measurement of arterial volume flow.
Journal of vascular surgery 1992;16(4):520-6.
1992: Alexander W Clowes; MM Clowes; T R Kirkman; C L Jackson; Y P Au; Richard D Kenagy
Heparin inhibits the expression of tissue-type plasminogen activator by smooth muscle cells in injured rat carotid artery.
Circulation research 1992;70(6):1128-36.
1992: Y P Au; K F Montgomery; Alexander W Clowes
Heparin inhibits collagenase gene expression mediated by phorbol ester-responsive element in primate arterial smooth muscle cells.
Circulation research 1992;70(5):1062-9.
1992: Y P Au; Richard D Kenagy; Alexander W Clowes
Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis.
The Journal of biological chemistry 1992;267(5):3438-44.
1992: C M Lynch; MM Clowes; William R A Osborne; Alexander W Clowes; A Dusty Miller
Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1138-42.
1992: Arkadiusz Jawien; Daniel F Bowen-Pope; V Lindner; Stephen M Schwartz; Alexander W Clowes
Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.
The Journal of clinical investigation 1992;89(2):507-11.
1991: Ted R Kohler; T R Kirkman; Larry W Kraiss; Brenda K Zierler; Alexander W Clowes
Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Circulation research 1991;69(6):1557-65.
1991: Larry W Kraiss; T R Kirkman; Ted R Kohler; Brenda K Zierler; Alexander W Clowes
Shear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(6):1844-52.
1991: Alexander W Clowes; MM Clowes; SM Vergel; R K Müller; Jerry S Powell; F Hefti; H R Baumgartner
Heparin and cilazapril together inhibit injury-induced intimal hyperplasia.
Hypertension 1991;18(4 Suppl):II65-9.
1991: Alexander W Clowes; Michael A Reidy
Prevention of stenosis after vascular reconstruction: pharmacologic control of intimal hyperplasia--a review.
Journal of vascular surgery 1991;13(6):885-91.
1991: Alexander W Clowes; Ted R Kohler
Graft endothelialization: the role of angiogenic mechanisms.
Journal of vascular surgery 1991;13(5):734-6.
1991: K Johansen; Ted R Kohler; Stephen C Nicholls; R Eugene Zierler; Alexander W Clowes; Andris Kazmers
Ruptured abdominal aortic aneurysm: the Harborview experience.
Journal of vascular surgery 1991;13(2):240-5; discussion 245-7.
1991: M A Golden; Y P Au; T R Kirkman; Josiah N Wilcox; Elaine W Raines; Russell Ross; Alexander W Clowes
Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation.
The Journal of clinical investigation 1991;87(2):406-14.
1990: J Fingerle; Y P Au; Alexander W Clowes; Michael A Reidy
Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury.
Arteriosclerosis (Dallas, Tex.) 1990;10(6):1082-7.
1990: Ted R Kohler; T R Kirkman; David F Gordon; Alexander W Clowes
Mechanism of long-term degeneration of arterialized vein grafts.
American journal of surgery 1990;160(3):257-61.
1990: AD Snow; R P Bolender; Thomas N Wight; Alexander W Clowes
Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells.
The American journal of pathology 1990;137(2):313-30.
1990: Alexander W Clowes; MM Clowes; Y P Au; Michael A Reidy; D Belin
Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery.
Circulation research 1990;67(1):61-7.
1990: Y P Au; T W Wang; Alexander W Clowes
Nucleotide and deduced amino acid sequences of baboon urokinase-type plasminogen activator.
Nucleic acids research 1990;18(11):3411.
1990: M A Golden; Stephen R Hanson; T R Kirkman; P A Schneider; Alexander W Clowes
Healing of polytetrafluoroethylene arterial grafts is influenced by graft porosity.
Journal of vascular surgery 1990;11(6):838-44; discussion 845.
1990: M A Golden; Y P Au; Richard D Kenagy; Alexander W Clowes
Growth factor gene expression by intimal cells in healing polytetrafluoroethylene grafts.
Journal of vascular surgery 1990;11(4):580-5.
1989: D A Healy; R Eugene Zierler; Stephen C Nicholls; Alexander W Clowes; Jean F Primozich; Robert O Bergelin; D Eugene Strandness
Long-term follow-up and clinical outcome of carotid restenosis.
Journal of vascular surgery 1989;10(6):662-8; discussion 668-9.
1989: J Fingerle; R Johnson; Alexander W Clowes; Mark W Majesky; Michael A Reidy
Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8412-6.
1989: D A Healy; Alexander W Clowes; R Eugene Zierler; Stephen C Nicholls; Robert O Bergelin; Jean F Primozich; D Eugene Strandness
Immediate and long-term results of carotid endarterectomy.
Stroke; a journal of cerebral circulation 1989;20(9):1138-42.
1989: Alexander W Clowes; MM Clowes
Inhibition of smooth muscle cell proliferation by heparin molecules.
Transplantation proceedings 1989;21(4):3700-1.
1989: Ted R Kohler; T Kirkman; Alexander W Clowes
Effect of heparin on adaptation of vein grafts to arterial circulation.
Arteriosclerosis (Dallas, Tex.) 1989;9(4):523-8.
1989: R M Zwolak; T R Kirkman; Alexander W Clowes
Atherosclerosis in rabbit vein grafts.
Arteriosclerosis (Dallas, Tex.) 1989;9(3):374-9.
1989: Alexander W Clowes; MM Clowes; J Fingerle; Michael A Reidy
Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation.
Laboratory investigation; a journal of technical methods and pathology 1989;60(3):360-4.
1989: Andris Kazmers; Gregory L Moneta; J D Harley; M L Goldman; Alexander W Clowes
Treatment of acute renal artery occlusion after percutaneous transluminal angioplasty.
Journal of vascular surgery 1989;9(3):487-92.
1989: Ted R Kohler; T R Kirkman; Alexander W Clowes
The effect of rigid external support on vein graft adaptation to the arterial circulation.
Journal of vascular surgery 1989;9(2):277-85.
1989: Alexander W Clowes; MM Clowes; J Fingerle; Michael A Reidy
Regulation of smooth muscle cell growth in injured artery.
Journal of cardiovascular pharmacology 1989;14 Suppl 6():S12-15.
1988: R K Zacharias; T R Kirkman; Richard D Kenagy; Daniel F Bowen-Pope; Alexander W Clowes
Growth factor production by polytetrafluoroethylene vascular grafts.
Journal of vascular surgery 1988;7(4):606-10.
1988: K H Sprugel; J M McPherson; Alexander W Clowes; Russell Ross
The effects of different growth factors in subcutaneous wound chambers.
Progress in clinical and biological research 1988;266():77-91.
1987: K H Sprugel; J M McPherson; Alexander W Clowes; Russell Ross
Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.
The American journal of pathology 1987;129(3):601-13.
1987: Gregory L Moneta; D C Taylor; Stephen C Nicholls; Robert O Bergelin; R Eugene Zierler; Andris Kazmers; Alexander W Clowes; D Eugene Strandness
Operative versus nonoperative management of asymptomatic high-grade internal carotid artery stenosis: improved results with endarterectomy.
Stroke; a journal of cerebral circulation 1987;18(6):1005-10.
1987: R K Zacharias; T R Kirkman; Alexander W Clowes
Mechanisms of healing in synthetic grafts.
Journal of vascular surgery 1987;6(5):429-36.
1987: Alexander W Clowes; R K Zacharias; T R Kirkman
Early endothelial coverage of synthetic arterial grafts: porosity revisited.
American journal of surgery 1987;153(5):501-4.
1987: Alexander W Clowes; Michael A Reidy
Mechanisms of arterial graft failure: the role of cellular proliferation.
Annals of the New York Academy of Sciences 1987;516():673-8.
1986: Alexander W Clowes; T R Kirkman; MM Clowes
Mechanisms of arterial graft failure. II. Chronic endothelial and smooth muscle cell proliferation in healing polytetrafluoroethylene prostheses.
Journal of vascular surgery 1986;3(6):877-84.