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Martine Clozel

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Keith Morrison; Rolf Studer; Roland Ernst; Franck Haag; Katalin Kauser; Martine Clozel
Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.
Martin H Bolli; Christoph Boss; Stephan Buchmann; Daniel Bur; Martine Clozel; Walter Fischli; Patrick Hess; Marc Iglarz; Solange Meyer; Josiane Rein; Markus Rey; Alexander Treiber; Christoph A Binkert; Thomas Weller
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Luca Piali; Sylvie Froidevaux; Patrick Hess; Oliver Nayler; Martin H Bolli; Eva Schlosser; Christopher Kohl; Beat Steiner; Martine Clozel
The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.

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2012: Keith Morrison; Rolf Studer; Roland Ernst; Franck Haag; Katalin Kauser; Martine Clozel
Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.
The Journal of pharmacology and experimental therapeutics 2012;343(3):547-55.
2012: Martin H Bolli; Christoph Boss; Stephan Buchmann; Daniel Bur; Martine Clozel; Walter Fischli; Patrick Hess; Marc Iglarz; Solange Meyer; Josiane Rein; Markus Rey; Alexander Treiber; Christoph A Binkert; Thomas Weller
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Journal of medicinal chemistry 2012;55(17):7849-61.
2011: Luca Piali; Sylvie Froidevaux; Patrick Hess; Oliver Nayler; Martin H Bolli; Eva Schlosser; Christopher Kohl; Beat Steiner; Martine Clozel
The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.
The Journal of pharmacology and experimental therapeutics 2011;337(2):547-56.
2011: Yasmina Bauer; Patrick Hess; Changbin Qiu; Axel Klenk; Bérengère Renault; Daniel Wanner; Rolf Studer; Nina Killer; Anna Katharina Stalder; Manuel Stritt; Daniel Stefan Strasser; Hervé Farine; Katalin Kauser; Martine Clozel; Walter Fischli; Oliver Nayler
Identification of cathepsin L as a potential sex-specific biomarker for renal damage.
Hypertension 2011;57(4):795-801.
2011: Martine Clozel
Between confidentiality and scientific exchange: the place of publication in drug discovery and pharmaceutical research.
Science translational medicine 2011;3(67):67cm2.
2010: Keith Morrison; Roland Ernst; Patrick Hess; Rolf Studer; Martine Clozel
Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.
The Journal of pharmacology and experimental therapeutics 2010;335(1):249-55.
2009: Markus Rey; Patrick Hess; Martine Clozel
Monocrotaline-induced pulmonary hypertension in Wistar rats.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2009;Chapter 5():Unit 5.56.
2008: Douglas G Farmer; Fady Kaldas; Dean M Anselmo; Masamichi Katori; Xiu-Da Shen; Charles Lassman; Marian Kaldas; Martine Clozel; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2008;14(12):1737-44.
2008: Marc Iglarz; Christoph Binkert; Keith Morrison; Walter Fischli; John Gatfield; Alexander Treiber; Thomas Weller; Martin H Bolli; Christoph Boss; Stephan Buchmann; Bruno Capeleto; Patrick Hess; Changbin Qiu; Martine Clozel
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2008;327(3):736-45.
2007: Marc Iglarz; Martine Clozel
Mechanisms of ET-1-induced endothelial dysfunction.
Journal of cardiovascular pharmacology 2007;50(6):621-8.
2007: Patrick Hess; Markus Rey; D Wanner; B Steiner; Martine Clozel
Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects.
Laboratory animals 2007;41(4):470-80.
2007: Richard F Kefford; Jane McNeil Beith; Guy Arthur Van Hazel; Michael J Millward; James Marshall Trotter; david wyld; Rada Kusic; Revati Shreeniwas; Adele Morganti; Andrea Ballmer; Eleonor Segal; Oliver Nayler; Martine Clozel
A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma.
Investigational new drugs 2007;25(3):247-52.
2007: Alexander Treiber; O Morand; Martine Clozel
The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(3):298-314.
2007: Catherine Brisbare-Roch; Jasper Dingemanse; Ralf Koberstein; Petra Hoever; Hamed Aissaoui; Susan Flores; Celia Mueller; Oliver Nayler; J M A van Gerven; Sanne L de Haas; Patrick Hess; Changbin Qiu; Stephan Buchmann; Michael W Scherz; Thomas Weller; Walter Fischli; Martine Clozel; François Jenck
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Nature medicine 2007;13(2):150-5.
2007: David Montani; Rogerio Souza; Christoph A Binkert; Walter Fischli; Gérald Simonneau; Martine Clozel; Marc Humbert
Endothelin-1/endothelin-3 ratio: a potential prognostic factor of pulmonary arterial hypertension.
Chest 2007;131(1):101-8.
2006: Martine Clozel; Patrick Hess; Markus Rey; Marc Iglarz; Christoph A Binkert; Changbin Qiu
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):967-73.
2006: Martine Clozel; Patrick Hess; Changbin Qiu; Shuang-Shuang Ding; Markus Rey
The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1115-21.
2005: Martine Clozel; Hashem Salloukh
Role of endothelin in fibrosis and anti-fibrotic potential of bosentan.
Annals of medicine 2005;37(1):2-12.
2004: Martine Clozel; Christoph A Binkert; Magdalena Birker-Robaczewska; Céline Boukhadra; Shuang-Shuang Ding; Walter Fischli; Patrick Hess; Boris Mathys; Keith Morrison; Celia Müller; Claus Müller; Oliver Nayler; Changbin Qiu; Markus Rey; Michael W Scherz; Jörg Velker; Thomas Weller; Jian-Fei Xi; Patrick Ziltener
Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System.
The Journal of pharmacology and experimental therapeutics 2004;311(1):204-12.
2004: Martin H Bolli; Judith Marfurt; Corinna Grisostomi; Christoph Boss; Christoph A Binkert; Patrick Hess; Alexander Treiber; Eric Thorin; Keith Morrison; Stephan Buchmann; Daniel Bur; Henri Ramuz; Martine Clozel; Walter Fischli; Thomas Weller
Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.
Journal of medicinal chemistry 2004;47(11):2776-95.
2004: Alexander Treiber; Ralph Schneiter; Stephane Delahaye; Martine Clozel
Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1121-9.
2004: Cristiane F Freitas; Renato Faro; Desanka Dragosavac; Martine Clozel; Gilberto De Nucci; Edson Antunes
Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs.
Journal of cardiovascular pharmacology 2004;43(1):106-12.
2003: Shuang-Shuang Ding; Changbin Qiu; Patrick Hess; Jian-Fei Xi; Nan Zheng; Martine Clozel
Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat.
Journal of cardiovascular pharmacology 2003;42(1):48-54.
2003: Martin H Bolli; Christoph Boss; Martine Clozel; Walter Fischli; Patrick Hess; Thomas Weller
The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(5):955-9.
2003: Christoph Boss; Martin H Bolli; Thomas Weller; Walter Fischli; Martine Clozel
Bis-sulfonamides as endothelin receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(5):951-4.
2003: Martine Clozel
Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit?
Annals of medicine 2003;35(8):605-13.
2002: Marc de Gasparo; Patrick Hess; Martine Clozel; Elke Persohn; Danielle Roman; paul germann; Jean-Paul Clozel; Randy L Webb
Combination of low-dose valsartan and enalapril improves endothelial dysfunction and coronary reserve in Nomega-nitro-L-arginine methyl ester-treated spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2002;40(5):789-800.
2002: Jasper Dingemanse; Martine Clozel; Paul L M van Giersbergen
Entry-into-humans study with tezosentan, an intravenous dual endothelin receptor antagonist.
Journal of cardiovascular pharmacology 2002;39(6):795-802.
2002: Jasper Dingemanse; Martine Clozel; Paul L M van Giersbergen
Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects.
British journal of clinical pharmacology 2002;53(4):355-62.
2002: Paul L M van Giersbergen; Alexander Treiber; Martine Clozel; Frédéric Bodin; Jasper Dingemanse
In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide.
Clinical pharmacology and therapeutics 2002;71(4):253-62.
2002: Shuang-Shuang Ding; Changbin Qiu; Patrick Hess; Jian-Fei Xi; Jean-Paul Clozel; Martine Clozel
Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure.
Cardiovascular research 2002;53(4):963-70.
2002: Martine Clozel; Changbin Qiu; Chang-Shen Qiu; Patrick Hess; Jean-Paul Clozel
Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.
Journal of the American College of Cardiology 2002;39(1):142-7.
2001: Changbin Qiu; Shuang-Shuang Ding; Patrick Hess; Jean-Paul Clozel; Martine Clozel
Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure.
Journal of cardiovascular pharmacology 2001;38(2):317-24.
2001: C B Qiu; C S Qiu; Patrick Hess; Jean-Paul Clozel; Martine Clozel
Additional effects of endothelin receptor blockade and angiotensin converting enzyme inhibition in rats with chronic heart failure.
Acta pharmacologica Sinica 2001;22(6):541-8.
1999: Martine Clozel; Patrick Hess; Walter Fischli; Bernd-Michael Löffler; Ralf Michael Zwacka; A Reuter; Hans Weiher
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease.
Experimental gerontology 1999;34(8):1007-15.
1999: Martine Clozel; Henri Ramuz; Jean-Paul Clozel; V Breu; Patrick Hess; Bernd-Michael Löffler; P Coassolo; S Roux
Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use.
The Journal of pharmacology and experimental therapeutics 1999;290(2):840-6.
1999: S Roux; V Breu; S I Ertel; Martine Clozel
Endothelin antagonism with bosentan: a review of potential applications.
Journal of molecular medicine (Berlin, Germany) 1999;77(4):364-76.
1999: Martine Clozel; Changbin Qiu; R Osterwalder; A Roeckel; P Bruneval; D Heudes; Jean-Paul Clozel
Effects of nonpeptide endothelin receptor antagonists in rats with reduced renal mass.
Journal of cardiovascular pharmacology 1999;33(4):611-8.
1999: H Karam; Olivier Valdenaire; M F Belair; C Prigent-Sassy; A Rakotosalama; Martine Clozel; J Itskovitz; P Bruneval
The endothelin system in human and monkey ovaries: in situ gene expression of the different components.
Cell and tissue research 1999;295(1):101-9.
1998: V Breu; S I Ertel; S Roux; Martine Clozel
The pharmacology of bosentan.
Expert opinion on investigational drugs 1998;7(7):1173-92.
1997: S Roux; V Breu; Thomas Giller; W Neidhart; Henri Ramuz; P Coassolo; Jean-Paul Clozel; Martine Clozel
Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1110-8.
1997: Thomas Giller; V Breu; Olivier Valdenaire; Martine Clozel
Absence of ET(B)-mediated contraction in Piebald-lethal mice.
Life sciences 1997;61(3):255-63.
1996: H Karam; D Heudes; M F Gonzales; Bernd-Michael Löffler; Martine Clozel; J P Clozel
Respective role of humoral factors and blood pressure in aortic remodeling of DOCA hypertensive rats.
American journal of hypertension 1996;9(10 Pt 1):991-8.
1996: H Karam; D Heudes; P Bruneval; M F Gonzales; Bernd-Michael Löffler; Martine Clozel; J P Clozel
Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.
Hypertension 1996;28(3):379-85.
1996: Martine Clozel; V Breu
The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443.
FEBS letters 1996;383(1-2):42-5.
1996: V Breu; Martine Clozel; K Burri; G Hirth; W Neidhart; H Ramuz
In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ETB receptor.
FEBS letters 1996;383(1-2):37-41.
1996: P Brändli; Bernd-Michael Löffler; V Breu; R Osterwalder; J P Maire; Martine Clozel
Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater.
Pain 1996;64(2):315-22.
1996: H Karam; D Heudes; P Hess; M F Gonzales; Bernd-Michael Löffler; Martine Clozel; J P Clozel
Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.
Cardiovascular research 1996;31(2):287-95.
1996: P H Dagassan; V Breu; Martine Clozel; A Künzli; P Vogt; M Turina; W Kiowski; J P Clozel
Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries.
Journal of cardiovascular pharmacology 1996;27(1):147-53.
1995: S Roux; Bernd-Michael Löffler; G A Gray; U Sprecher; Martine Clozel; J P Clozel
The role of endothelin in experimental cerebral vasospasm.
Neurosurgery 1995;37(1):78-85; discussion 85-6.
1995: S Roux; Martine Clozel; R Wolfgang; U Sprecher; J P Clozel
Comparative evaluation of acute cerebral vasospasm by the microsphere and the angiography techniques.
Journal of neuroscience methods 1995;59(2):245-52.
1995: V Breu; K Hashido; C Broger; C Miyamoto; Yukio Furuichi; A Hayes; B Kalina; Bernd-Michael Löffler; H Ramuz; Martine Clozel
Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptors.
European journal of biochemistry / FEBS 1995;231(1):266-70.
1995: H Karam; P Bruneval; J P Clozel; Bernd-Michael Löffler; J Bariéty; Martine Clozel
Role of endothelin in acute renal failure due to rhabdomyolysis in rats.
The Journal of pharmacology and experimental therapeutics 1995;274(1):481-6.
1995: Martine Clozel; G A Gray
Are there different ETB receptors mediating constriction and relaxation?
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S262-4.
1995: P H Dagassan; Martine Clozel; V Breu; J P Clozel
Role of endothelin in spontaneous phasic contraction of human coronary arteries.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S200-3.
1995: G A Gray; V Breu; Martine Clozel
Endothelin receptors that modulate contraction of the rat fundus.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S126-9.
1995: J R Teerlink; J P Carteaux; U Sprecher; Bernd-Michael Löffler; Martine Clozel; J P Clozel
Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs.
The American journal of physiology 1995;268(1 Pt 2):H432-40.
1994: P H Dagassan; V Breu; Martine Clozel; J P Clozel
Role of endothelin during reperfusion after ischemia in isolated perfused rat heart.
Journal of cardiovascular pharmacology 1994;24(6):867-74.
1994: J R Teerlink; Bernd-Michael Löffler; P Hess; J P Maire; Martine Clozel; J P Clozel
Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).
Circulation 1994;90(5):2510-8.
1994: Martine Clozel; V Breu; G A Gray; B Kalina; Bernd-Michael Löffler; K Burri; J M Cassal; G Hirth; M Müller; W Neidhart
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1994;270(1):228-35.
1994: G A Gray; Bernd-Michael Löffler; Martine Clozel
Characterization of endothelin receptors mediating contraction of rabbit saphenous vein.
The American journal of physiology 1994;266(3 Pt 2):H959-66.
1994: J R Teerlink; G A Gray; Martine Clozel; J P Clozel
Increased vascular responsiveness to norepinephrine in rats with heart failure is endothelium dependent. Dissociation of basal and stimulated nitric oxide release.
Circulation 1994;89(1):393-401.
1994: J R Teerlink; V Breu; U Sprecher; Martine Clozel; J P Clozel
Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.
Circulation research 1994;74(1):105-14.
1994: M Véniant; J P Clozel; P Hess; Martine Clozel
Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs.
Life sciences 1994;55(6):445-54.
1993: V Breu; Bernd-Michael Löffler; Martine Clozel
In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors.
FEBS letters 1993;334(2):210-4.
1993: Bernd-Michael Löffler; V Breu; Martine Clozel
Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma.
FEBS letters 1993;333(1-2):108-10.
1993: Martine Clozel; V Breu; K Burri; J M Cassal; Walter Fischli; G A Gray; G Hirth; Bernd-Michael Löffler; M Müller; W Neidhart
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist.
Nature 1993;365(6448):759-61.
1993: G A Gray; Martine Clozel; J P Clozel; H R Baumgartner
Effects of calcium channel blockade on the aortic intima in spontaneously hypertensive rats.
Hypertension 1993;22(4):569-76.
1993: Martine Clozel; Bernd-Michael Löffler; V Breu; L Hilfiger; J P Maire; B Butscha
Downregulation of endothelin receptors by autocrine production of endothelin-1.
The American journal of physiology 1993;265(1 Pt 1):C188-92.
1993: Bernd-Michael Löffler; S Roux; B Kalina; Martine Clozel; J P Clozel
Influence of congestive heart failure on endothelin levels and receptors in rabbits.
Journal of molecular and cellular cardiology 1993;25(4):407-16.
1993: Martine Clozel; H Watanabe
BQ-123, a peptidic endothelin ETA receptor antagonist, prevents the early cerebral vasospasm following subarachnoid hemorrhage after intracisternal but not intravenous injection.
Life sciences 1993;52(9):825-34.
1993: Martine Clozel; V Breu; G A Gray; Bernd-Michael Löffler
In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S377-9.
1993: M Véniant; J P Clozel; H Kuhn; Martine Clozel
Protective effect of cilazapril on the cerebral circulation.
Journal of cardiovascular pharmacology 1993;22 Suppl 1():S30-5.
1992: Martine Clozel; G A Gray; V Breu; Bernd-Michael Löffler; R Osterwalder
The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo.
Biochemical and biophysical research communications 1992;186(2):867-73.
1992: M Véniant; J P Clozel; H Kuhn; Martine Clozel
Protective effect of cilazapril on the cerebral circulation.
Journal of cardiovascular pharmacology 1992;19 Suppl 6():S94-9.
1991: Martine Clozel
Mechanism of action of angiotensin converting enzyme inhibitors on endothelial function in hypertension.
Hypertension 1991;18(4 Suppl):II37-42.