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Miriam Cnop

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Michael Maris; Chantal Mathieu; Sofie Robert; Etienne Waelkens; Miriam Cnop; Rita Derua; Wannes D'Hertog; Miriam H Hernangomez; Lut Overbergh
Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction.
Miriam Cnop; J Mark Cooper; Chantal Depondt; Décio L Eizirik; Audrey Begu; Jean-Pierre Brion; Anne Clark; Mariana Igoillo-Esteve; Arnulf H Koeppen; Laurence Ladrière; Dionysios Lefkaditis; Piero Marchetti; Ihsane Marhfour; Xavier Moles Lopez; Fabrice Moore; Anyishai E Musuaya; Massimo Pandolfo; Myriam Rai; Anthony H V Schapira; Yasmina Serroukh; Françoise Féry
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.
Decio L Eizirik; Miriam Cnop
Mining genes in type 2 diabetic islets and finding gold.

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All Publications

2013: Michael Maris; Chantal Mathieu; Sofie Robert; Etienne Waelkens; Miriam Cnop; Rita Derua; Wannes D'Hertog; Miriam H Hernangomez; Lut Overbergh
Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction.
Journal of proteome research 2013;12(1):347-62.
2012: Miriam Cnop; J Mark Cooper; Chantal Depondt; Décio L Eizirik; Audrey Begu; Jean-Pierre Brion; Anne Clark; Mariana Igoillo-Esteve; Arnulf H Koeppen; Laurence Ladrière; Dionysios Lefkaditis; Piero Marchetti; Ihsane Marhfour; Xavier Moles Lopez; Fabrice Moore; Anyishai E Musuaya; Massimo Pandolfo; Myriam Rai; Anthony H V Schapira; Yasmina Serroukh; Françoise Féry
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.
Annals of neurology 2012;72(6):971-82.
2012: Decio L Eizirik; Miriam Cnop
Mining genes in type 2 diabetic islets and finding gold.
Cell metabolism 2012;16(5):555-7.
2012: Daniel A Cunha; Décio L Eizirik; Makiko Fukaya; Carla M Germano; Esteban N Gurzov; Conny Gysemans; Heather P Harding; Mariana Igoillo-Esteve; Piero Marchetti; Ihsane Marhfour; Lorella Marselli; Chantal Mathieu; Najib Naamane; David Ron; Jean-Marie Vanderwinden; Miriam Cnop
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
Diabetes 2012;61(11):2763-75.
2012: Michela Miani; Laurence Ladrière; Miriam Cnop; Maikel L Colli; Decio L Eizirik
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.
Endocrinology 2012;153(7):3017-28.
2012: M Maris; L Overbergh; E Verdrengh; A Waget; R Burcelin; Alessandra K Cardozo; Miriam Cnop; J P M Cunha; Decio L Eizirik; T Gotoh; Conny Gysemans; Chantal Mathieu
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.
Diabetologia 2012;55(4):1167-78.
2012: Michael Volkmar; Ute Volkmar; Mariana Igoillo-Esteve; Piero Marchetti; Matilde Masini; Najib Naamane; Matladi N Ndlovu; Marco Bugliani; Emilie Calonne; Miriam Cnop; Daniel A Cunha; Sarah Dedeurwaerder; Matthieu Defrance; Silvia Del Guerra; Rachel Deplus; Decio L Eizirik; François Fuks
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
The EMBO journal 2012;31(6):1405-26.
2012: Décio L Eizirik; Lorna Gregory; Linda Hughes; Mariana Igoillo-Esteve; Gerton Lunter; Piero Marchetti; Lorella Marselli; Mark I McCarthy; Fernanda Ortis; Michael Sammeth; Izortze Santin; Giorgia Sisino; Jenny Barthson; Guy Bottu; Thomas Bouckenooghe; Luc Bouwens; Maikel L Colli; Miriam Cnop
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.
PLoS genetics 2012;8(3):e1002552.
2011: Bente B Johansson; Stefan Johansson; Susanne Lindquist; Anders Molven; Lise Bjørkhaug; Miriam Cnop; Karianne Fjeld; Torgeir Flatmark; Olle Hernell; Dag Hoem; Helge Raeder; Anja Ragvin; Jaakko Saraste; Erling Tjora; Janniche Torsvik; Mette Vesterhus; Pål R Njølstad
Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease.
The Journal of biological chemistry 2011;286(40):34593-605.
2011: Miriam Cnop; S J Hughes; Mariana Igoillo-Esteve; J N Walker; I Cnop; A Clark
Longevity of human islet α- and β-cells.
Diabetes, obesity & metabolism 2011;13 Suppl 1():39-46.
2011: Bertrand Vos; Miriam Cnop; Jacques Devière; Françoise Féry; Christophe Moreno; Nathalie Nagy; Pierre Vereerstraeten; Michael Adler
Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease.
Acta gastro-enterologica Belgica 2011;74(3):389-94.
2011: Michael Maris; Lut Overbergh; Etienne Waelkens; Miriam Cnop; Daniel A Cunha; Wannes D'Hertog; Tatsuro Koike; Hannelie Korf; Chantal Mathieu
Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid.
Journal of proteome research 2011;10(8):3372-85.
2011: Mariana Igoillo-Esteve; Esteban N Gurzov; Decio L Eizirik; Miriam Cnop
The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.
Endocrinology 2011;152(2):447-56.
2011: Katleen Lemaire; Rodrigo F Moura; Mikaela Granvik; Mariana Igoillo-Esteve; Hans E Hohmeier; Nico Hendrickx; Christopher B Newgard; Etienne Waelkens; Miriam Cnop; Frans Schuit
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
PloS one 2011;6(4):e18517.
2010: Michael Maris; Gabriela B Ferreira; Wannes D'Hertog; Miriam Cnop; Etienne Waelkens; Lut Overbergh; Chantal Mathieu
High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach.
Journal of proteome research 2010;9(12):6274-87.
2010: Miriam Cnop; Laurence Ladrière; Mariana Igoillo-Esteve; R F Moura; Daniel Cunha
Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction.
Diabetes, obesity & metabolism 2010;12 Suppl 2():76-82.
2010: Mariana Igoillo-Esteve; L Marselli; Daniel Cunha; Laurence Ladrière; Fernanda Ortis; F A Grieco; F Dotta; G C Weir; P Marchetti; Decio L Eizirik; Miriam Cnop
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.
Diabetologia 2010;53(7):1395-405.
2010: Laurence Ladrière; Mariana Igoillo-Esteve; Daniel Cunha; Jean-Pierre Brion; Marco Bugliani; Piero Marchetti; Décio L Eizirik; Miriam Cnop
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
The Journal of clinical endocrinology and metabolism 2010;95(3):1442-9.
2010: Miriam Cnop; S J Hughes; Mariana Igoillo-Esteve; M B Hoppa; F Sayyed; L van de Laar; J H Gunter; E J P de Koning; G V Walls; D W G Gray; P R V Johnson; B C Hansen; J F Morris; Miriam Pipeleers-Marichal; I Cnop; A Clark
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.
Diabetologia 2010;53(2):321-30.
2010: Decio L Eizirik; Miriam Cnop
ER stress in pancreatic beta cells: the thin red line between adaptation and failure.
Science signaling 2010;3(110):pe7.
2010: Dana Martinovici; Valérie Ransy; Serge Vanden Eijnden; Céline Ridremont; Anne Pardou; Marie Cassart; Freddy Avni; Catherine Donner; Pierre Lingier; Anne Mathieu; Béatrice Gulbis; Véronique De Brouckère; Miriam Cnop; Marc Abramowicz; Julie Désir
Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn.
European journal of medical genetics 2010;53(1):25-8.
2009: Daniel A Cunha; Laurence Ladrière; Fernanda Ortis; Mariana Igoillo-Esteve; Esteban N Gurzov; Roberto Lupi; Piero Marchetti; Décio L Eizirik; Miriam Cnop
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
Diabetes 2009;58(12):2851-62.
2009: Ning Li; Thierry Brun; Miriam Cnop; Daniel Cunha; Decio L Eizirik; Pierre Maechler
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
The Journal of biological chemistry 2009;284(35):23602-12.
2009: Giovanni Coppola; Daniele Marmolino; Daning Lu; Qing Wang; Miriam Cnop; Myriam Rai; Fabio Acquaviva; Sergio Cocozza; Massimo Pandolfo; Daniel Geschwind
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.
Human molecular genetics 2009;18(13):2452-61.
2009: Fabrice Moore; Maikel L Colli; Miriam Cnop; Mariana Igoillo-Esteve; Alessandra K Cardozo; Daniel Cunha; Marco Bugliani; Piero Marchetti; Decio L Eizirik
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Diabetes 2009;58(6):1283-91.
2008: Miriam Cnop; Mariana Igoillo-Esteve; Daniel Cunha; Laurence Ladrière; Decio L Eizirik
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
Biochemical Society transactions 2008;36(Pt 5):909-15.
2008: Daniel Cunha; Paul Hekerman; Laurence Ladrière; Angie Bazarra-Castro; Fernanda Ortis; Marion C Wakeham; Fabrice Moore; Joanne Rasschaert; Alessandra K Cardozo; Elisa Bellomo; Lutgart Overbergh; Chantal Mathieu; Roberto Lupi; Tsonwin Hai; Andre Herchuelz; Piero Marchetti; Guy Rutter; Decio L Eizirik; Miriam Cnop
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Journal of cell science 2008;121(Pt 14):2308-18.
2008: Miriam Cnop
Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes.
Biochemical Society transactions 2008;36(Pt 3):348-52.
2008: Amir J Guri; Raquel Hontecillas; Gerardo Ferrer; Oriol Casagran; Umesh Wankhade; Alexis M Noble; Decio L Eizirik; Fernanda Ortis; Miriam Cnop; Dongmin Liu; Hongwei Si; Josep Bassaganya-Riera
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.
The Journal of nutritional biochemistry 2008;19(4):216-28.
2008: Decio L Eizirik; Alessandra K Cardozo; Miriam Cnop
The role for endoplasmic reticulum stress in diabetes mellitus.
Endocrine reviews 2008;29(1):42-61.
2007: Piero Marchetti; Marco Bugliani; ROBERTO LUPI; Lorella Marselli; Matilde Masini; Ugo Boggi; Franco Filipponi; G C Weir; Decio L Eizirik; Miriam Cnop
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.
Diabetologia 2007;50(12):2486-94.
2007: Pierre Pirot; Fernanda Ortis; Miriam Cnop; Yanjun Ma; Linda M Hendershot; Decio L Eizirik; Alessandra K Cardozo
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.
Diabetes 2007;56(4):1069-77.
2007: Miriam Cnop; Josep Vidal; Rebecca L Hull; Kristina M Utzschneider; Darcy B Carr; Todd D Schraw; Philipp E Scherer; Edward J Boyko; Wilfred Y Fujimoto; Steven E Kahn
Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.
Diabetes care 2007;30(3):677-82.
2007: Miriam Cnop; Laurence Ladriere; Paul Hekerman; Fernanda Ortis; Alessandra K Cardozo; Zeynep Dogusan; Daisy Flamez; Michael Boyce; Junying Yuan; Decio L Eizirik
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
The Journal of biological chemistry 2007;282(6):3989-97.
2006: Ilham Kharroubi; C-H Lee; Paul Hekerman; Martine I Darville; R M Evans; Decio L Eizirik; Miriam Cnop
BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Diabetologia 2006;49(10):2350-8.
2005: Miriam Cnop; Nils Welsh; Jean-Christophe Jonas; Anne Jörns; Sigurd Lenzen; Decio L Eizirik
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
Diabetes 2005;54 Suppl 2():S97-107.
2005: Nils Welsh; Miriam Cnop; Ilham Kharroubi; Marco Bugliani; ROBERTO LUPI; Piero Marchetti; Decio L Eizirik
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
Diabetes 2005;54(11):3238-44.
2004: Ilham Kharroubi; Laurence Ladrière; Alessandra K Cardozo; Zeynep Dogusan; Miriam Cnop; Decio L Eizirik
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.
Endocrinology 2004;145(11):5087-96.
2003: Ilham Kharroubi; Joanne Rasschaert; Decio L Eizirik; Miriam Cnop
Expression of adiponectin receptors in pancreatic beta cells.
Biochemical and biophysical research communications 2003;312(4):1118-22.
2003: Miriam Cnop; Peter J Havel; Kristina M Utzschneider; Darcy B Carr; M K Sinha; Edward J Boyko; Barbara M Retzlaff; Robert H Knopp; John D Brunzell; Steven E Kahn
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.
Diabetologia 2003;46(4):459-69.
2003: Rebecca L Hull; Sofianos Andrikopoulos; C Bruce Verchere; Josep Vidal; Feng Wang; Miriam Cnop; Ronald L Prigeon; Steven E Kahn
Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.
Diabetes 2003;52(2):372-9.
2003: Josep Vidal; C Bruce Verchere; Sofianos Andrikopoulos; Feng Wang; Rebecca L Hull; Miriam Cnop; Katherine L Olin; R C LeBoeuf; Kevin D O'Brien; Alan Chait; Steven E Kahn
The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
Diabetologia 2003;46(1):71-9.
2003: Delma J Nieves; Miriam Cnop; Barbara M Retzlaff; Carolyn Walden; John D Brunzell; Robert H Knopp; Steven E Kahn
The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.
Diabetes 2003;52(1):172-9.
2002: Miriam Cnop; Jean Claude Hannaert; Annick Y Grupping; Daniel G Pipeleers
Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.
Endocrinology 2002;143(9):3449-53.
2002: Christine C Jensen; Miriam Cnop; Rebecca L Hull; Wilfred Y Fujimoto; Steven E Kahn
Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.
Diabetes 2002;51(7):2170-8.
2002: Miriam Cnop; Jean Claude Hannaert; Daniel G Pipeleers
Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.
Biochemical pharmacology 2002;63(7):1281-5.
2002: Miriam Cnop; Melinda J Landchild; Josep Vidal; Peter J Havel; Negar G Knowles; Darcy R Carr; Feng Wang; Rebecca L Hull; Edward J Boyko; Barbara M Retzlaff; Carolyn Walden; Robert H Knopp; Steven E Kahn
The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.
Diabetes 2002;51(4):1005-15.
2001: Feng Wang; Rebecca L Hull; Josep Vidal; Miriam Cnop; Steven E Kahn
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Diabetes 2001;50(11):2514-20.
2001: Miriam Cnop; Jean Claude Hannaert; A Hoorens; Decio L Eizirik; Daniel G Pipeleers
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
Diabetes 2001;50(8):1771-7.
2000: Miriam Cnop; Annick Y Grupping; A Hoorens; Luc Bouwens; Miriam Pipeleers-Marichal; Daniel Pipeleers
Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.
The American journal of pathology 2000;156(1):237-44.
1997: Annick Y Grupping; Miriam Cnop; Chris Van Schravendijk; Jean Claude Hannaert; Theo Van berkel; Daniel G Pipeleers
Low density lipoprotein binding and uptake by human and rat islet beta cells.
Endocrinology 1997;138(10):4064-8.