Melanie Cobb

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Deaton Staci L; Sengupta Samarpita; Cobb Melanie H
WNK Kinases and Blood Pressure Control.
Dioum Elhadji M; Wauson Eric M; Cobb Melanie H
MAP-ping unconventional protein-DNA interactions.
Jivan Arif; Earnest Svetlana; Juang Yu-Chi; Cobb Melanie H
Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.

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All Publications

2009: Deaton Staci L; Sengupta Samarpita; Cobb Melanie H
WNK Kinases and Blood Pressure Control.
Current hypertension reports 2009;11(6):421-6.
2009: Dioum Elhadji M; Wauson Eric M; Cobb Melanie H
MAP-ping unconventional protein-DNA interactions.
Cell 2009;139(3):462-3.
2009: Jivan Arif; Earnest Svetlana; Juang Yu-Chi; Cobb Melanie H
Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.
The Journal of biological chemistry 2009;284(43):29437-45.
2009: Zheng Yanhua; Xia Yan; Hawke David; Halle Maxime; Tremblay Michel L; Gao Xiang; Zhou Xiao Zhen; Aldape Kenneth; Cobb Melanie H; Xie Keping; He Jie; Lu Zhimin
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Molecular cell 2009;35(1):11-25.
2009: Lee Seung-Jae; Cobb Melanie H; Goldsmith Elizabeth J
Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Protein science : a publication of the Protein Society 2009;18(2):304-13.
2009: Chen Wei; Chen Yue; Xu Bing-e; Juang Yu-Chi; Stippec Steve; Zhao Yingming; Cobb Melanie H
Regulation of a third conserved phosphorylation site in SGK1.
The Journal of biological chemistry 2009;284(6):3453-60.
2009: Min Xiaoshan; Akella Radha; He Haixia; Humphreys John M; Tsutakawa Susan E; Lee Seung-Jae; Tainer John A; Cobb Melanie H; Goldsmith Elizabeth J
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
Structure (London, England : 1993) 2009;17(1):96-104.
2009: Chen Yue; Chen Wei; Cobb Melanie H; Zhao Yingming
PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):761-6.
2009: Shao Chunli; Cobb Melanie H
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
The Journal of biological chemistry 2009;284(5):3117-24.
2008: Lawrence Michael C; McGlynn Kathleen; Shao Chunli; Duan Lingling; Naziruddin Bashoo; Levy Marlon F; Cobb Melanie H
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13315-20.
2008: Lawrence Michael C; Jivan Arif; Shao Chunli; Duan Lingling; Goad Daryl; Zaganjor Elma; Osborne Jihan; McGlynn Kathleen; Stippec Steve; Earnest Svetlana; Chen Wei; Cobb Melanie H
The roles of MAPKs in disease.
Cell research 2008;18(4):436-42.
2008: Lawrence M; Shao C; Duan L; McGlynn K; Cobb M H
The protein kinases ERK1/2 and their roles in pancreatic beta cells.
Acta physiologica (Oxford, England) 2008;192(1):11-7.
2007: Oh Eunjin; Heise Charles J; English Jessie M; Cobb Melanie H; Thurmond Debbie C
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.
The Journal of biological chemistry 2007;282(45):32613-22.
2007: Huang Chou Long; Cha Seung Kuy; Wang Hao Ran; Xie Jian; Cobb Melanie H
WNKs: protein kinases with a unique kinase domain.
Experimental & molecular medicine 2007;39(5):565-73.
2007: Yazicioglu Mustafa N; Goad Daryl L; Ranganathan Aarati; Whitehurst Angelique W; Goldsmith Elizabeth J; Cobb Melanie H
Mutations in ERK2 binding sites affect nuclear entry.
The Journal of biological chemistry 2007;282(39):28759-67.
2007: Lawrence Michael C; McGlynn Kathleen; Naziruddin Bashoo; Levy Marlon F; Cobb Melanie H
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11518-25.
2007: Lee Byung-Hoon; Chen Wei; Stippec Steve; Cobb Melanie H
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
The Journal of biological chemistry 2007;282(25):17985-96.
2007: Raman M; Chen W; Cobb M H
Differential regulation and properties of MAPKs.
Oncogene 2007;26(22):3100-12.
2007: Raman Malavika; Earnest Svetlana; Zhang Kai; Zhao Yingming; Cobb Melanie H
TAO kinases mediate activation of p38 in response to DNA damage.
The EMBO journal 2007;26(8):2005-14.
2007: Casar Berta; Sanz-Moreno Victoria; Yazicioglu Mustafa N; Rodríguez Javier; Berciano María T; Lafarga Miguel; Cobb Melanie H; Crespo Piero
Mxi2 promotes stimulus-independent ERK nuclear translocation.
The EMBO journal 2007;26(3):635-46.
2006: Wilsbacher Julie L; Juang Yu-Chi; Khokhlatchev Andrei V; Gallagher Ewen; Binns Derk; Goldsmith Elizabeth J; Cobb Melanie H
Characterization of mitogen-activated protein kinase (MAPK) dimers.
Biochemistry 2006;45(44):13175-82.
2006: Heise Charles J; Cobb Melanie H
Expression and characterization of MAP kinases in bacteria.
Methods (San Diego, Calif.) 2006;40(3):209-12.
2006: Polychronopoulos Sarantis; Verykokakis Mihalis; Yazicioglu Mustafa N; Sakarellos-Daitsiotis Maria; Cobb Melanie H; Mavrothalassitis George
The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs.
The Journal of biological chemistry 2006;281(35):25601-11.
2006: Xie Jian; Craig Leonard; Cobb Melanie H; Huang Chou-Long
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.
Pediatric nephrology (Berlin, Germany) 2006;21(9):1231-6.
2006: Anselmo Anthony N; Earnest Svetlana; Chen Wei; Juang Yu-Chi; Kim Sung Chan; Zhao Yingming; Cobb Melanie H
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10883-8.
2006: Ranganathan Aarati; Yazicioglu Mustafa N; Cobb Melanie H
The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.
The Journal of biological chemistry 2006;281(23):15645-52.
2006: Ranganathan Aarati; Pearson Gray W; Chrestensen Carol A; Sturgill Thomas W; Cobb Melanie H
The MAP kinase ERK5 binds to and phosphorylates p90 RSK.
Archives of biochemistry and biophysics 2006;449(1-2):8-16.
2006: Pearson Gray W; Earnest Svetlana; Cobb Melanie H
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.
Molecular and cellular biology 2006;26(8):3039-47.
2006: Gibson Tara Beers; Lawrence Michael C; Gibson Craig J; Vanderbilt Colleen A; McGlynn Kathleen; Arnette Don; Chen Wei; Collins Julie; Naziruddin Bashoo; Levy Marlon F; Ehrlich Barbara E; Cobb Melanie H
Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells.
Diabetes 2006;55(4):1066-73.
2006: Raman Malavika; Cobb Melanie H
TGF-beta regulation by Emilin1: new links in the etiology of hypertension.
Cell 2006;124(5):893-5.
2006: Chen Zhui; Cobb Melanie H
Activation of MEKK1 by Rho GTPases.
Methods in enzymology 2006;406():468-78.
2005: Xu Bing-E; Stippec Steve; Lazrak Ahmed; Huang Chou-Long; Cobb Melanie H
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.
The Journal of biological chemistry 2005;280(40):34218-23.
2005: Xu Bing-e; Stippec Steve; Chu Po-Yin; Lazrak Ahmed; Li Xin-Ji; Lee Byung-Hoon; English Jessie M; Ortega Bernardo; Huang Chou-Long; Cobb Melanie H
WNK1 activates SGK1 to regulate the epithelial sodium channel.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10315-20.
2005: Lawrence Michael C; McGlynn Kathleen; Park Byung-Hyun; Cobb Melanie H
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.
The Journal of biological chemistry 2005;280(29):26751-9.
2005: Lenertz Lisa Y; Lee Byung-Hoon; Min Xiaoshan; Xu Bing-e; Wedin Kyle; Earnest Svetlana; Goldsmith Elizabeth J; Cobb Melanie H
Properties of WNK1 and implications for other family members.
The Journal of biological chemistry 2005;280(29):26653-8.
2005: Dufton Christopher; Marcora Edoardo; Chae Ji Hyung; McCullough James; Eby Jennifer; Hausburg Melissa; Stein Gretchen H; Khoo Shih; Cobb Melanie H; Lee Jacqueline E
Context-dependent regulation of NeuroD activity and protein accumulation.
Molecular and cellular neurosciences 2005;28(4):727-36.
2005: Xu Bing E; Lee Byung Hoon; Min Xiaoshan; Lenertz Lisa; Heise Charles J; Stippec Steve; Goldsmith Elizabeth J; Cobb Melanie H
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Cell research 2005;15(1):6-10.
2004: Whitehurst Angelique; Cobb Melanie H; White Michael A
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.
Molecular and cellular biology 2004;24(23):10145-50.
2004: Zhou Tianjun; Raman Malavika; Gao Yan; Earnest Svetlana; Chen Zhu; Machius Mischa; Cobb Melanie H; Goldsmith Elizabeth J
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.
Structure (London, England : 1993) 2004;12(10):1891-900.
2004: Lee Byung-Hoon; Min Xiaoshan; Heise Charles J; Xu Bing-E; Chen She; Shu Hongjun; Luby-Phelps Kate; Goldsmith Elizabeth J; Cobb Melanie H
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Molecular cell 2004;15(5):741-51.
2004: Anselmo Anthony N; Cobb Melanie H
Protein kinase function and glutathionylation.
The Biochemical journal 2004;381(Pt 3):e1-2.
2004: Min Xiaoshan; Lee Byung-Hoon; Cobb Melanie H; Goldsmith Elizabeth J
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure (London, England : 1993) 2004;12(7):1303-11.
2004: Whitehurst Angelique W; Robinson Fred L; Moore Mary Shannon; Cobb Melanie H
The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.
The Journal of biological chemistry 2004;279(13):12840-7.
2004: Chen Wei; Yazicioglu Mustafa; Cobb Melanie H
Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
The Journal of biological chemistry 2004;279(12):11129-36.
2004: Xu Bing-E; Stippec Steve; Lenertz Lisa; Lee Byung-Hoon; Zhang Wei; Lee Youn-Kyoung; Cobb Melanie H
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.
The Journal of biological chemistry 2004;279(9):7826-31.
2004: Gallagher Ewen D; Gutowski Stephen; Sternweis Paul C; Cobb Melanie H
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.
The Journal of biological chemistry 2004;279(3):1872-7.
2004: Khoo Shih; Gibson Tara Beers; Arnette Don; Lawrence Michael; January Bridgette; McGlynn Kathleen; Vanderbilt Colleen A; Griffen Steven C; German Michael S; Cobb Melanie H
MAP kinases and their roles in pancreatic beta-cells.
Cell biochemistry and biophysics 2004;40(3 Suppl):191-200.
2004: Goldsmith Elizabeth J; Cobb Melanie H; Chang Chung-I
Structure of MAPKs.
Methods in molecular biology (Clifton, N.J.) 2004;250():127-44.
2003: Raman Malavika; Cobb Melanie H
MAP kinase modules: many roads home.
Current biology : CB 2003;13(22):R886-8.
2003: Khoo Shih; Griffen Steven C; Xia Ying; Baer Richard J; German Michael S; Cobb Melanie H
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.
The Journal of biological chemistry 2003;278(35):32969-77.
2003: Arnette Don; Gibson Tara Beers; Lawrence Michael C; January Bridgette; Khoo Shih; McGlynn Kathleen; Vanderbilt Colleen A; Cobb Melanie H
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.
The Journal of biological chemistry 2003;278(35):32517-25.
2003: Chen Zhu; Raman Malavika; Chen Linda; Lee Sheu Fen; Gilman Alfred G; Cobb Melanie H
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
The Journal of biological chemistry 2003;278(25):22278-83.
2002: Xu Bing-e; Min Xiaoshan; Stippec Steve; Lee Byung-Hoon; Goldsmith Elizabeth J; Cobb Melanie H
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
The Journal of biological chemistry 2002;277(50):48456-62.
2002: Chen Wei; White Michael A; Cobb Melanie H
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway.
The Journal of biological chemistry 2002;277(51):49105-10.
2002: Pearson Gray W; Cobb Melanie H
Cell condition-dependent regulation of ERK5 by cAMP.
The Journal of biological chemistry 2002;277(50):48094-8.
2002: Gallagher Ewen D; Xu Shuichan; Moomaw Carolyn; Slaughter Clive A; Cobb Melanie H
Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.
The Journal of biological chemistry 2002;277(48):45785-92.
2002: Christerson Lori B; Gallagher Ewen; Vanderbilt Colleen A; Whitehurst Angelique W; Wells Clark; Kazempour Roxana; Sternweis Paul C; Cobb Melanie H
p115 Rho GTPase activating protein interacts with MEKK1.
Journal of cellular physiology 2002;192(2):200-8.
2002: Chang Chung I; Xu Bing-e; Akella Radha; Cobb Melanie H; Goldsmith Elizabeth J
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Molecular cell 2002;9(6):1241-9.
2002: Lu Zhimin; Xu Shuichan; Joazeiro Claudio; Cobb Melanie H; Hunter Tony
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
Molecular cell 2002;9(5):945-56.
2002: Whitehurst Angelique W; Wilsbacher Julie L; You Youngjai; Luby-Phelps Kate; Moore Mary Shannon; Cobb Melanie H
ERK2 enters the nucleus by a carrier-independent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7496-501.
2002: Robinson Fred L; Whitehurst Angelique W; Raman Malavika; Cobb Melanie H
Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1.
The Journal of biological chemistry 2002;277(17):14844-52.
2002: Berman Kevin S; Verma Udit N; Harburg Gwyndolen; Minna John D; Cobb Melanie H; Gaynor Richard B
Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):354-60.
2002: Robinson Megan J; Xu Be Bing-e; Stippec Stephen; Cobb Melanie H
Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.
The Journal of biological chemistry 2002;277(7):5094-100.
2002: English Jessie M; Cobb Melanie H
Pharmacological inhibitors of MAPK pathways.
Trends in pharmacological sciences 2002;23(1):40-5.
2001: Gallagher E D; Cobb M H
ERKs weigh in on ribosome mass.
Molecular cell 2001;8(5):932-3.
2001: Berman K S; Hutchison M; Avery L; Cobb M H
kin-18, a C. elegans protein kinase involved in feeding.
Gene 2001;279(2):137-47.
2001: Chen Z; Gibson T B; Robinson F; Silvestro L; Pearson G; Xu B; Wright A; Vanderbilt C; Cobb M H
MAP kinases.
Chemical reviews 2001;101(8):2449-76.
2001: Xu Be; Stippec S; Robinson F L; Cobb M H
Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking.
The Journal of biological chemistry 2001;276(28):26509-15.
2001: Chen Z; Cobb M H
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.
The Journal of biological chemistry 2001;276(19):16070-5.
2001: Pearson G; Robinson F; Beers Gibson T; Xu B E; Karandikar M; Berman K; Cobb M H
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Endocrine reviews 2001;22(2):153-83.
2001: Pearson G; English J M; White M A; Cobb M H
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation.
The Journal of biological chemistry 2001;276(11):7927-31.
2001: Wilsbacher J L; Cobb M H
Bacterial expression of activated mitogen-activated protein kinases.
Methods in enzymology 2001;332():387-400.
2000: Pearson G; Bumeister R; Henry D O; Cobb M H; White M A
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation.
The Journal of biological chemistry 2000;275(48):37303-6.
2000: Karandikar M; Xu S; Cobb M H
MEKK1 binds raf-1 and the ERK2 cascade components.
The Journal of biological chemistry 2000;275(51):40120-7.
2000: Xu B; English J M; Wilsbacher J L; Stippec S; Goldsmith E J; Cobb M H
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
The Journal of biological chemistry 2000;275(22):16795-801.
2000: Frost J A; Swantek J L; Stippec S; Yin M J; Gaynor R; Cobb M H
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.
The Journal of biological chemistry 2000;275(26):19693-9.
2000: Swantek J L; Tsen M F; Cobb M H; Thomas J A
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4301-6.
1999: Karandikar M; Cobb M H
Scaffolding and protein interactions in MAP kinase modules.
Cell calcium 1999;26(5):219-26.
1999: English J; Pearson G; Wilsbacher J; Swantek J; Karandikar M; Xu S; Cobb M H
New insights into the control of MAP kinase pathways.
Experimental cell research 1999;253(1):255-70.
1999: Xu B e; Wilsbacher J L; Collisson T; Cobb M H
The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo.
The Journal of biological chemistry 1999;274(48):34029-35.
1999: Wang J; Frost J A; Cobb M H; Ross E M
Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase.
The Journal of biological chemistry 1999;274(44):31641-7.
1999: English J M; Pearson G; Hockenberry T; Shivakumar L; White M A; Cobb M H
Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control.
The Journal of biological chemistry 1999;274(44):31588-92.
1999: Chen Z; Hutchison M; Cobb M H
Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.
The Journal of biological chemistry 1999;274(40):28803-7.
1999: Wilsbacher J L; Goldsmith E J; Cobb M H
Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases.
The Journal of biological chemistry 1999;274(24):16988-94.
1999: Swantek J L; Christerson L; Cobb M H
Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent.
The Journal of biological chemistry 1999;274(17):11667-71.
1999: Christerson L B; Vanderbilt C A; Cobb M H
MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions.
Cell motility and the cytoskeleton 1999;43(3):186-98.
1998: Robinson M J; Stippec S A; Goldsmith E; White M A; Cobb M H
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.
Current biology : CB 1998;8(21):1141-50.
1998: Hutchison M; Berman K S; Cobb M H
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.
The Journal of biological chemistry 1998;273(44):28625-32.
1998: Frost J A; Khokhlatchev A; Stippec S; White M A; Cobb M H
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.
The Journal of biological chemistry 1998;273(43):28191-8.
1998: Wang Z; Canagarajah B J; Boehm J C; Kassisà S; Cobb M H; Young P R; Abdel-Meguid S; Adams J L; Goldsmith E J
Structural basis of inhibitor selectivity in MAP kinases.
Structure (London, England : 1993) 1998;6(9):1117-28.
1998: Dang A; Frost J A; Cobb M H
The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.
The Journal of biological chemistry 1998;273(31):19909-13.
1998: Yin M J; Christerson L B; Yamamoto Y; Kwak Y T; Xu S; Mercurio F; Barbosa M; Cobb M H; Gaynor R B
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.
Cell 1998;93(5):875-84.
1998: Khokhlatchev A V; Canagarajah B; Wilsbacher J; Robinson M; Atkinson M; Goldsmith E; Cobb M H
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.
Cell 1998;93(4):605-15.
1998: English J M; Pearson G; Baer R; Cobb M H
Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.
The Journal of biological chemistry 1998;273(7):3854-60.
1997: Xu S; Cobb M H
MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.
The Journal of biological chemistry 1997;272(51):32056-60.
1997: Swantek J L; Cobb M H; Geppert T D
Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.
Molecular and cellular biology 1997;17(11):6274-82.
1997: Xu S; Khoo S; Dang A; Witt S; Do V; Zhen E; Schaefer E M; Cobb M H
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1618-25.
1997: Canagarajah B J; Khokhlatchev A; Cobb M H; Goldsmith E J
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell 1997;90(5):859-69.
1997: Khoo S; Cobb M H
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5599-604.
1997: Khokhlatchev A; Xu S; English J; Wu P; Schaefer E; Cobb M H
Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases.
The Journal of biological chemistry 1997;272(17):11057-62.
1997: Robinson M J; Cobb M H
Mitogen-activated protein kinase pathways.
Current opinion in cell biology 1997;9(2):180-6.
1997: Wang Z; Harkins P C; Ulevitch R J; Han J; Cobb M H; Goldsmith E J
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2327-32.
1996: Gilbreth M; Yang P; Wang D; Frost J; Polverino A; Cobb M H; Marcus S
The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13802-7.
1996: Robinson M J; Cheng M; Khokhlatchev A; Ebert D; Ahn N; Guan K L; Stein B; Goldsmith E; Cobb M H
Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity.
The Journal of biological chemistry 1996;271(47):29734-9.
1996: Frost J A; Xu S; Hutchison M R; Marcus S; Cobb M H
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members.
Molecular and cellular biology 1996;16(7):3707-13.
1996: Cheng M; Zhen E; Robinson M J; Ebert D; Goldsmith E; Cobb M H
Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3.
The Journal of biological chemistry 1996;271(20):12057-62.
1996: Xu S; Robbins D J; Christerson L B; English J M; Vanderbilt C A; Cobb M H
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5291-5.
1996: Robinson M J; Harkins P C; Zhang J; Baer R; Haycock J W; Cobb M H; Goldsmith E J
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry 1996;35(18):5641-6.
1996: Cheng M; Boulton T G; Cobb M H
ERK3 is a constitutively nuclear protein kinase.
The Journal of biological chemistry 1996;271(15):8951-8.
1996: Cobb M H; Xu S; Cheng M; Ebert D; Robbins D; Goldsmith E; Robinson M
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.
Advances in pharmacology (San Diego, Calif.) 1996;36():49-65.
1995: English J M; Vanderbilt C A; Xu S; Marcus S; Cobb M H
Isolation of MEK5 and differential expression of alternatively spliced forms.
The Journal of biological chemistry 1995;270(48):28897-902.
1995: Polverino A; Frost J; Yang P; Hutchison M; Neiman A M; Cobb M H; Marcus S
Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.
The Journal of biological chemistry 1995;270(44):26067-70.
1995: Xu S; Robbins D; Frost J; Dang A; Lange-Carter C; Cobb M H
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6808-12.
1995: Cobb M H; Goldsmith E J
How MAP kinases are regulated.
The Journal of biological chemistry 1995;270(25):14843-6.
1995: Marcus S; Polverino A; Chang E; Robbins D; Cobb M H; Wigler M H
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6180-4.
1995: Zhang J; Zhang F; Ebert D; Cobb M H; Goldsmith E J
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.
Structure (London, England : 1993) 1995;3(3):299-307.
1994: James G L; Brown M S; Cobb M H; Goldstein J L
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
The Journal of biological chemistry 1994;269(44):27705-14.
1994: Robbins D J; Zhen E; Cheng M; Xu S; Ebert D; Cobb M H
MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.
Advances in cancer research 1994;63():93-116.
1994: Cobb M H; Xu S; Hepler J E; Hutchison M; Frost J; Robbins D J
Regulation of the MAP kinase cascade.
Cellular & molecular biology research 1994;40(3):253-6.
1993: Robbins D J; Zhen E; Cheng M; Xu S; Vanderbilt C A; Ebert D; Garcia C; Dang A; Cobb M H
Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3.
Journal of the American Society of Nephrology : JASN 1993;4(5):1104-10.
1993: Zhang F; Robbins D J; Cobb M H; Goldsmith E J
Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag.
Journal of molecular biology 1993;233(3):550-2.
1993: Robbins D J; Zhen E; Owaki H; Vanderbilt C A; Ebert D; Geppert T D; Cobb M H
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.
The Journal of biological chemistry 1993;268(7):5097-106.
1993: Cheng J T; Cobb M H; Baer R
Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.
Molecular and cellular biology 1993;13(2):801-8.
1992: Drechsel D N; Hyman A A; Cobb M H; Kirschner M W
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
Molecular biology of the cell 1992;3(10):1141-54.
1992: Robbins D J; Cheng M; Zhen E; Vanderbilt C A; Feig L A; Cobb M H
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6924-8.
1992: Seger R; Ahn N G; Posada J; Munar E S; Jensen A M; Cooper J A; Cobb M H; Krebs E G
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
The Journal of biological chemistry 1992;267(20):14373-81.
1992: Robbins D J; Cobb M H
Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.
Molecular biology of the cell 1992;3(3):299-308.
1992: Owaki H; Makar R; Boulton T G; Cobb M H; Geppert T D
Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
Biochemical and biophysical research communications 1992;182(3):1416-22.
1991: Cobb M H; Boulton T G; Robbins D J
Extracellular signal-regulated kinases: ERKs in progress.
Cell regulation 1991;2(12):965-78.
1991: Cobb M H; Robbins D J; Boulton T G
ERKs, extracellular signal-regulated MAP-2 kinases.
Current opinion in cell biology 1991;3(6):1025-32.
1991: Rowles J; Slaughter C; Moomaw C; Hsu J; Cobb M H
Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9548-52.
1991: Seger R; Ahn N G; Boulton T G; Yancopoulos G D; Panayotatos N; Radziejewska E; Ericsson L; Bratlien R L; Cobb M H; Krebs E G
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6142-6.
1991: Boulton T G; Nye S H; Robbins D J; Ip N Y; Radziejewska E; Morgenbesser S D; DePinho R A; Panayotatos N; Cobb M H; Yancopoulos G D
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Cell 1991;65(4):663-75.
1991: Boulton T G; Cobb M H
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.
Cell regulation 1991;2(5):357-71.
1991: Boulton T G; Gregory J S; Cobb M H
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase.
Biochemistry 1991;30(1):278-86.
1990: Boulton T G; Yancopoulos G D; Gregory J S; Slaughter C; Moomaw C; Hsu J; Cobb M H
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control.
Science (New York, N.Y.) 1990;249(4964):64-7.
1990: Boulton T G; Gregory J S; Jong S M; Wang L H; Ellis L; Cobb M H
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.
The Journal of biological chemistry 1990;265(5):2713-9.
1989: Cobb M H; Sang B C; Gonzalez R; Goldsmith E; Ellis L
Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction.
The Journal of biological chemistry 1989;264(31):18701-6.
1989: Gregory J S; Boulton T G; Sang B C; Cobb M H
An insulin-stimulated ribosomal protein S6 kinase from rabbit liver.
The Journal of biological chemistry 1989;264(31):18397-401.
1988: Ellis L; Levitan A; Cobb M H; Ramos P
Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector.
Journal of virology 1988;62(5):1634-9.
1986: Cobb M H; Burr J G; Linder M E; Gray T B; Gregory J S
A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus.
Biochemical and biophysical research communications 1986;137(2):702-8.

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