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Melanie Cobb

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TOP 3
Jihan K Osborne; Mitsuo Sato; David S Shames; Misty D Shields; Ignacio I Wistuba; Luc Girard; Joshua X Gonzales; Ashwinikumar Kulkarni; Jill Everland Larsen; John D Minna; Melanie H Cobb
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
Aileen M Klein; Elma Zaganjor; Melanie H Cobb
Chromatin-tethered MAPKs.
Eric M Wauson; Elma Zaganjor; Melanie H Cobb
Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

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All Publications

2013: Jihan K Osborne; Mitsuo Sato; David S Shames; Misty D Shields; Ignacio I Wistuba; Luc Girard; Joshua X Gonzales; Ashwinikumar Kulkarni; Jill Everland Larsen; John D Minna; Melanie H Cobb
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6524-9.
2013: Aileen M Klein; Elma Zaganjor; Melanie H Cobb
Chromatin-tethered MAPKs.
Current opinion in cell biology 2013;25(2):272-7.
2013: Eric M Wauson; Elma Zaganjor; Melanie H Cobb
Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.
Autophagy 2013;9(3):418-9.
2012: Samarpita Sengupta; Steve Stippec; Szu-Wei Tu; Kyle Wedin; Svetlana Earnest; Katherine Luby-Phelps; Melanie H Cobb
Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
The Journal of biological chemistry 2012;287(45):37868-79.
2012: A-Young Lee; Jon Self; Steve Stippec; Fan Yang; She Chen; Wei Chen; Xiaojun Ding; Yu-Chi Juang; Melanie H Cobb
Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16841-6.
2012: Eric M Wauson; Elma Zaganjor; Angie L Bookout; Chris P Chambers; Ralph J DeBerardinis; Anwesha B Ghosh; Marcy L Guerra; Michele R Hutchison; Arif Jivan; A-Young Lee; Kathleen McGlynn; Melanie H Cobb
The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.
Molecular cell 2012;47(6):851-62.
2011: Szu-Wei Tu; Abhijit Bugde; Katherine Luby-Phelps; Melanie H Cobb
WNK1 is required for mitosis and abscission.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1385-90.
2010: Lingling Duan; Melanie H Cobb
Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22314-9.
2010: Aileen M Klein; Elhadji DIOUM; Melanie H Cobb
Exposing contingency plans for kinase networks.
Cell 2010;143(6):867-9.
2010: Charles J Heise; Bing-e Xu; Staci L Deaton; Seung-Kuy Cha; Chih-Jen Cheng; Svetlana Earnest; Samarpita Sengupta; Yu-Chi Juang; Steve Stippec; Yingda Xu; Yingming Zhao; Chou-Long Huang; Melanie H Cobb
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.
The Journal of biological chemistry 2010;285(33):25161-7.
2010: Chunli Shao; Michael C Lawrence; Melanie H Cobb
Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells.
The Journal of biological chemistry 2010;285(26):19710-9.
2010: Arif Jivan; Aarati Ranganathan; Melanie H Cobb
Reconstitution of the nuclear transport of the MAP kinase ERK2.
Methods in molecular biology (Clifton, N.J.) 2010;661():273-85.
2009: Michael C Lawrence; Chunli Shao; Kathleen McGlynn; Bashoo Naziruddin; Marlon F Levy; Melanie H Cobb
Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22181-6.
2009: Staci L Deaton; Samarpita Sengupta; Melanie H Cobb
WNK kinases and blood pressure control.
Current hypertension reports 2009;11(6):421-6.
2009: Elhadji DIOUM; Eric M Wauson; Melanie H Cobb
MAP-ping unconventional protein-DNA interactions.
Cell 2009;139(3):462-3.
2009: Arif Jivan; Svetlana Earnest; Yu-Chi Juang; Melanie H Cobb
Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.
The Journal of biological chemistry 2009;284(43):29437-45.
2009: Yanhua Zheng; Yan Xia; David Hawke; Maxime Halle; Michel L Tremblay; Xiang Gao; Xiao Zhen Zhou; Kenneth Aldape; Melanie H Cobb; Keping Xie; Jie He; Zhimin Lu
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Molecular cell 2009;35(1):11-25.
2009: Wei Chen; Yue Chen; Bing-e Xu; Yu-Chi Juang; Steve Stippec; Yingming Zhao; Melanie H Cobb
Regulation of a third conserved phosphorylation site in SGK1.
The Journal of biological chemistry 2009;284(6):3453-60.
2009: Seung-Jae Lee; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Protein science : a publication of the Protein Society 2009;18(2):304-13.
2009: Chunli Shao; Melanie H Cobb
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
The Journal of biological chemistry 2009;284(5):3117-24.
2009: Yue Chen; Wei Chen; Melanie H Cobb; Yingming Zhao
PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):761-6.
2009: Xiaoshan Min; Radha Akella; Haixia He; John M Humphreys; Susan Tsutakawa; Seung-Jae Lee; John A Tainer; Melanie H Cobb; Elizabeth J Goldsmith
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
Structure (London, England : 1993) 2009;17(1):96-104.
2008: Michael C Lawrence; Kathleen McGlynn; Chunli Shao; Lingling Duan; Bashoo Naziruddin; Marlon F Levy; Melanie H Cobb
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13315-20.
2008: Michael C Lawrence; Arif Jivan; Chunli Shao; Lingling Duan; Daryl Goad; Elma Zaganjor; Jihan Osborne; Kathleen McGlynn; Steve Stippec; Svetlana Earnest; Wei Chen; Melanie H Cobb
The roles of MAPKs in disease.
Cell research 2008;18(4):436-42.
2008: M Lawrence; C Shao; L Duan; Kathleen McGlynn; Melanie H Cobb
The protein kinases ERK1/2 and their roles in pancreatic beta cells.
Acta physiologica (Oxford, England) 2008;192(1):11-7.
2007: Eunjin Oh; Charles J Heise; Jessie M English; Melanie H Cobb; Debbie C Thurmond
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.
The Journal of biological chemistry 2007;282(45):32613-22.
2007: Chou-Long Huang; Seung-Kuy Cha; Hao Ran Wang; Jian Xie; Melanie H Cobb
WNKs: protein kinases with a unique kinase domain.
Experimental & molecular medicine 2007;39(5):565-73.
2007: Mustafa Yazicioglu; Daryl L Goad; Aarati Ranganathan; Angelique Whitehurst; Elizabeth J Goldsmith; Melanie H Cobb
Mutations in ERK2 binding sites affect nuclear entry.
The Journal of biological chemistry 2007;282(39):28759-67.
2007: Michael C Lawrence; Kathleen McGlynn; Bashoo Naziruddin; Marlon F Levy; Melanie H Cobb
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11518-25.
2007: Byung-Hoon Lee; Wei Chen; Steve Stippec; Melanie H Cobb
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
The Journal of biological chemistry 2007;282(25):17985-96.
2007: Malavika Raman; W Chen; Melanie H Cobb
Differential regulation and properties of MAPKs.
Oncogene 2007;26(22):3100-12.
2007: Malavika Raman; Svetlana Earnest; Kai Zhang; Yingming Zhao; Melanie H Cobb
TAO kinases mediate activation of p38 in response to DNA damage.
The EMBO journal 2007;26(8):2005-14.
2007: Berta CASAR; Victoria Sanz-Moreno; Mustafa Yazicioglu; Javier Rodríguez; María T Berciano; Miguel Lafarga; Melanie H Cobb; Piero Crespo
Mxi2 promotes stimulus-independent ERK nuclear translocation.
The EMBO journal 2007;26(3):635-46.
2006: Julie L Wilsbacher; Yu-Chi Juang; Andrei V Khokhlatchev; Ewen Gallagher; Derk D Binns; Elizabeth J Goldsmith; Melanie H Cobb
Characterization of mitogen-activated protein kinase (MAPK) dimers.
Biochemistry 2006;45(44):13175-82.
2006: Charles J Heise; Melanie H Cobb
Expression and characterization of MAP kinases in bacteria.
Methods (San Diego, Calif.) 2006;40(3):209-12.
2006: Sarantis Polychronopoulos; Mihalis Verykokakis; Mustafa Yazicioglu; Maria Sakarellos-Daitsiotis; Melanie H Cobb; George Mavrothalassitis
The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs.
The Journal of biological chemistry 2006;281(35):25601-11.
2006: Jian Xie; Leonard Craig; Melanie H Cobb; Chou-Long Huang
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.
Pediatric nephrology (Berlin, Germany) 2006;21(9):1231-6.
2006: Anthony N Anselmo; Svetlana Earnest; Wei Chen; Yu-Chi Juang; Sung Chan Kim; Yingming Zhao; Melanie H Cobb
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10883-8.
2006: Aarati Ranganathan; Mustafa Yazicioglu; Melanie H Cobb
The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.
The Journal of biological chemistry 2006;281(23):15645-52.
2006: Aarati Ranganathan; Gray W Pearson; Carol A Chrestensen; Thomas W Sturgill; Melanie H Cobb
The MAP kinase ERK5 binds to and phosphorylates p90 RSK.
Archives of biochemistry and biophysics 2006;449(1-2):8-16.
2006: Gray W Pearson; Svetlana Earnest; Melanie H Cobb
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.
Molecular and cellular biology 2006;26(8):3039-47.
2006: Tara Beers Gibson; Michael C Lawrence; Craig J Gibson; Colleen A Vanderbilt; Kathleen McGlynn; Don Arnette; Wei Chen; Julie Collins; Bashoo Naziruddin; Marlon F Levy; Barbara E Ehrlich; Melanie H Cobb
Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells.
Diabetes 2006;55(4):1066-73.
2006: Malavika Raman; Melanie H Cobb
TGF-beta regulation by Emilin1: new links in the etiology of hypertension.
Cell 2006;124(5):893-5.
2006: Zhui Chen; Melanie H Cobb
Activation of MEKK1 by Rho GTPases.
Methods in enzymology 2006;406():468-78.
2005: Bing-e Xu; Steve Stippec; Ahmed Lazrak; Chou-Long Huang; Melanie H Cobb
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.
The Journal of biological chemistry 2005;280(40):34218-23.
2005: Michael C Lawrence; Kathleen McGlynn; Byung-Hyun Park; Melanie H Cobb
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.
The Journal of biological chemistry 2005;280(29):26751-9.
2005: Lisa Lenertz; Byung-Hoon Lee; Xiaoshan Min; Bing-e Xu; Kyle Wedin; Svetlana Earnest; Elizabeth J Goldsmith; Melanie H Cobb
Properties of WNK1 and implications for other family members.
The Journal of biological chemistry 2005;280(29):26653-8.
2005: Bing-e Xu; Steve Stippec; Po-Yin Chu; Ahmed Lazrak; Xin-Ji Li; Byung-Hoon Lee; Jessie M English; Bernardo Ortega; Chou-Long Huang; Melanie H Cobb
WNK1 activates SGK1 to regulate the epithelial sodium channel.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10315-20.
2005: Christopher Dufton; Edoardo Marcora; Ji Hyung Chae; James McCullough; Jennifer Eby; Melissa Hausburg; Gretchen H Stein; Shih Khoo; Melanie H Cobb; Jacqueline E Lee
Context-dependent regulation of NeuroD activity and protein accumulation.
Molecular and cellular neurosciences 2005;28(4):727-36.
2005: Bing-e Xu; Byung Hoon Lee; Xiaoshan Min; Lisa Lenertz; Charles J Heise; Steve Stippec; Elizabeth J Goldsmith; Melanie H Cobb
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Cell research 2005;15(1):6-10.
2004: Angelique Whitehurst; Melanie H Cobb; Michael A White
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.
Molecular and cellular biology 2004;24(23):10145-50.
2004: Tianjun Zhou; Malavika Raman; Yan Gao; Svetlana Earnest; Zhu Chen; Mischa Machius; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.
Structure (London, England : 1993) 2004;12(10):1891-900.
2004: Byung-Hoon Lee; Xiaoshan Min; Charles J Heise; Bing-e Xu; She Chen; Hongjun Shu; Kate Luby-Phelps; Elizabeth J Goldsmith; Melanie H Cobb
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Molecular cell 2004;15(5):741-51.
2004: Anthony N Anselmo; Melanie H Cobb
Protein kinase function and glutathionylation.
The Biochemical journal 2004;381(Pt 3):e1-2.
2004: Xiaoshan Min; Byung-Hoon Lee; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure (London, England : 1993) 2004;12(7):1303-11.
2004: Angelique Whitehurst; Fred L Robinson; Mary Shannon Moore; Melanie H Cobb
The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.
The Journal of biological chemistry 2004;279(13):12840-7.
2004: Wei Chen; Mustafa Yazicioglu; Melanie H Cobb
Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
The Journal of biological chemistry 2004;279(12):11129-36.
2004: Bing-e Xu; Steve Stippec; Lisa Lenertz; Byung-Hoon Lee; Wei Zhang; Youn-Kyoung Lee; Melanie H Cobb
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.
The Journal of biological chemistry 2004;279(9):7826-31.
2004: Ewen D Gallagher; Stephen Gutowski; Paul C Sternweis; Melanie H Cobb
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.
The Journal of biological chemistry 2004;279(3):1872-7.
2004: Shih Khoo; Tara Beers Gibson; Don Arnette; Michael Lawrence; Bridgette January; Kathleen McGlynn; Colleen A Vanderbilt; Steven C Griffen; Michael S German; Melanie H Cobb
MAP kinases and their roles in pancreatic beta-cells.
Cell biochemistry and biophysics 2004;40(3 Suppl):191-200.
2004: Elizabeth J Goldsmith; Melanie H Cobb; Chung-I Chang
Structure of MAPKs.
Methods in molecular biology (Clifton, N.J.) 2004;250():127-44.
2003: Malavika Raman; Melanie H Cobb
MAP kinase modules: many roads home.
Current biology : CB 2003;13(22):R886-8.
2003: Shih Khoo; Steven C Griffen; Ying Xia; Richard J Baer; Michael S German; Melanie H Cobb
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.
The Journal of biological chemistry 2003;278(35):32969-77.
2003: Don Arnette; Tara Beers Gibson; Michael C Lawrence; Bridgette January; Shih Khoo; Kathleen McGlynn; Colleen A Vanderbilt; Melanie H Cobb
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.
The Journal of biological chemistry 2003;278(35):32517-25.
2003: Zhu Chen; Malavika Raman; Linda Chen; Sheu-Fen Lee; Alfred G Gilman; Melanie H Cobb
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
The Journal of biological chemistry 2003;278(25):22278-83.
2002: Wei Chen; Michael A White; Melanie H Cobb
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway.
The Journal of biological chemistry 2002;277(51):49105-10.
2002: Bing-e Xu; Xiaoshan Min; Steve Stippec; Byung-Hoon Lee; Elizabeth J Goldsmith; Melanie H Cobb
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
The Journal of biological chemistry 2002;277(50):48456-62.
2002: Gray W Pearson; Melanie H Cobb
Cell condition-dependent regulation of ERK5 by cAMP.
The Journal of biological chemistry 2002;277(50):48094-8.
2002: Ewen D Gallagher; Shuichan Xu; Carolyn Moomaw; Clive A Slaughter; Melanie H Cobb
Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.
The Journal of biological chemistry 2002;277(48):45785-92.
2002: Lori B Christerson; Ewen Gallagher; Colleen A Vanderbilt; Angelique Whitehurst; Clark Wells; Roxana Kazempour; Paul C Sternweis; Melanie H Cobb
p115 Rho GTPase activating protein interacts with MEKK1.
Journal of cellular physiology 2002;192(2):200-8.
2002: Chung I Chang; Bing-e Xu; Radha Akella; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Molecular cell 2002;9(6):1241-9.
2002: Angelique Whitehurst; Julie L Wilsbacher; Youngjai You; Kate Luby-Phelps; Mary Shannon Moore; Melanie H Cobb
ERK2 enters the nucleus by a carrier-independent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7496-501.
2002: Zhimin Lu; Shuichan Xu; Claudio A P Joazeiro; Melanie H Cobb; Tony Hunter
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
Molecular cell 2002;9(5):945-56.
2002: Fred L Robinson; Angelique Whitehurst; Malavika Raman; Melanie H Cobb
Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1.
The Journal of biological chemistry 2002;277(17):14844-52.
2002: Megan J Robinson; Bing-e Xu Be; Steve Stippec; Melanie H Cobb
Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.
The Journal of biological chemistry 2002;277(7):5094-100.
2002: Kevin S Berman; Udit N Verma; Gwyndolen C Harburg; John D Minna; Melanie H Cobb; Richard B Gaynor
Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):354-60.
2002: Jessie M English; Melanie H Cobb
Pharmacological inhibitors of MAPK pathways.
Trends in pharmacological sciences 2002;23(1):40-5.
2001: KS Berman; Michele R Hutchison; Leon Avery; Melanie H Cobb
kin-18, a C. elegans protein kinase involved in feeding.
Gene 2001;279(2):137-47.
2001: Ewen D Gallagher; Melanie H Cobb
ERKs weigh in on ribosome mass.
Molecular cell 2001;8(5):932-3.
2001: Z Chen; Tara Beers Gibson; Fred L Robinson; L Silvestro; G Pearson; B Xu; A Wright; Colleen A Vanderbilt; Melanie H Cobb
MAP kinases.
Chemical reviews 2001;101(8):2449-76.
2001: Steve Stippec; Fred L Robinson; Melanie H Cobb
Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking.
The Journal of biological chemistry 2001;276(28):26509-15.
2001: Zhouji Chen; Melanie H Cobb
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.
The Journal of biological chemistry 2001;276(19):16070-5.
2001: G Pearson; Fred L Robinson; T Beers Gibson; B E Xu; M Karandikar; K Berman; Melanie H Cobb
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Endocrine reviews 2001;22(2):153-83.
2001: G Pearson; Jessie M English; Michael A White; Melanie H Cobb
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation.
The Journal of biological chemistry 2001;276(11):7927-31.
2001: Julie L Wilsbacher; Melanie H Cobb
Bacterial expression of activated mitogen-activated protein kinases.
Methods in enzymology 2001;332():387-400.
2000: M Karandikar; Shuichan Xu; Melanie H Cobb
MEKK1 binds raf-1 and the ERK2 cascade components.
The Journal of biological chemistry 2000;275(51):40120-7.
2000: G Pearson; Ron Bumeister; Dale O Henry; Melanie H Cobb; Michael A White
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation.
The Journal of biological chemistry 2000;275(48):37303-6.
2000: Jeffrey A Frost; JL Swantek; Steve Stippec; MJ Yin; Richard B Gaynor; Melanie H Cobb
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.
The Journal of biological chemistry 2000;275(26):19693-9.
2000: B Xu; Jessie M English; Julie L Wilsbacher; Steve Stippec; Elizabeth J Goldsmith; Melanie H Cobb
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
The Journal of biological chemistry 2000;275(22):16795-801.
2000: JL Swantek; May F Tsen; Melanie H Cobb; James A Thomas
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4301-6.
1999: B e Xu; Julie L Wilsbacher; T Collisson; Melanie H Cobb
The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo.
The Journal of biological chemistry 1999;274(48):34029-35.
1999: J English; G Pearson; Julie L Wilsbacher; JL Swantek; M Karandikar; Shuichan Xu; Melanie H Cobb
New insights into the control of MAP kinase pathways.
Experimental cell research 1999;253(1):255-70.
1999: M Karandikar; Melanie H Cobb
Scaffolding and protein interactions in MAP kinase modules.
Cell calcium 1999;26(5):219-26.
1999: Jin Wang; Jeffrey A Frost; Melanie H Cobb; Elliott M Ross
Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase.
The Journal of biological chemistry 1999;274(44):31641-7.
1999: Jessie M English; G Pearson; T Hockenberry; Latha Shivakumar; Michael A White; Melanie H Cobb
Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control.
The Journal of biological chemistry 1999;274(44):31588-92.
1999: Zhouji Chen; Michele R Hutchison; Melanie H Cobb
Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.
The Journal of biological chemistry 1999;274(40):28803-7.
1999: Julie L Wilsbacher; Elizabeth J Goldsmith; Melanie H Cobb
Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases.
The Journal of biological chemistry 1999;274(24):16988-94.
1999: JL Swantek; Lori B Christerson; Melanie H Cobb
Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent.
The Journal of biological chemistry 1999;274(17):11667-71.
1999: Lori B Christerson; Colleen A Vanderbilt; Melanie H Cobb
MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions.
Cell motility and the cytoskeleton 1999;43(3):186-98.
1998: Michele R Hutchison; KS Berman; Melanie H Cobb
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.
The Journal of biological chemistry 1998;273(44):28625-32.
1998: Jeffrey A Frost; Andrei V Khokhlatchev; Steve Stippec; Michael A White; Melanie H Cobb
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.
The Journal of biological chemistry 1998;273(43):28191-8.
1998: M J Robinson; Steve Stippec; Elizabeth J Goldsmith; Michael A White; Melanie H Cobb
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.
Current biology : CB 1998;8(21):1141-50.
1998: Z Wang; BJ Canagarajah; J C Boehm; S Kassisà; Melanie H Cobb; Peter Young; Sherin S Abdel-Meguid; J L Adams; Elizabeth J Goldsmith
Structural basis of inhibitor selectivity in MAP kinases.
Structure (London, England : 1993) 1998;6(9):1117-28.
1998: A Dang; Jeffrey A Frost; Melanie H Cobb
The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.
The Journal of biological chemistry 1998;273(31):19909-13.
1998: MJ Yin; Lori B Christerson; Yumi Yamamoto; Youn-Tae Kwak; Shuichan Xu; Frank Mercurio; M Barbosa; Melanie H Cobb; Richard B Gaynor
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.
Cell 1998;93(5):875-84.
1998: Andrei V Khokhlatchev; BJ Canagarajah; Julie L Wilsbacher; M Robinson; M Atkinson; Elizabeth J Goldsmith; Melanie H Cobb
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.
Cell 1998;93(4):605-15.
1998: Jessie M English; G Pearson; R Baer; Melanie H Cobb
Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.
The Journal of biological chemistry 1998;273(7):3854-60.
1997: Shuichan Xu; Melanie H Cobb
MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.
The Journal of biological chemistry 1997;272(51):32056-60.
1997: JL Swantek; Melanie H Cobb; TD Geppert
Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.
Molecular and cellular biology 1997;17(11):6274-82.
1997: Shuichan Xu; Shih Khoo; A Dang; S Witt; V Do; E Zhen; Erik M Schaefer; Melanie H Cobb
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1618-25.
1997: BJ Canagarajah; Andrei V Khokhlatchev; Melanie H Cobb; Elizabeth J Goldsmith
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell 1997;90(5):859-69.
1997: Shih Khoo; Melanie H Cobb
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5599-604.
1997: Andrei V Khokhlatchev; Shuichan Xu; J English; P Wu; Erik M Schaefer; Melanie H Cobb
Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases.
The Journal of biological chemistry 1997;272(17):11057-62.
1997: M J Robinson; Melanie H Cobb
Mitogen-activated protein kinase pathways.
Current opinion in cell biology 1997;9(2):180-6.
1997: Z w Wang; PC Harkins; R J Ulevitch; J Han; Melanie H Cobb; E J Goldsmith
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2327-32.
1996: M Gilbreth; Peirong Yang; D Wang; Jeffrey A Frost; A Polverino; Melanie H Cobb; Stevan Marcus
The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13802-7.
1996: M J Robinson; M Cheng; Andrei V Khokhlatchev; D Ebert; N Ahn; K L Guan; B Stein; Elizabeth J Goldsmith; Melanie H Cobb
Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity.
The Journal of biological chemistry 1996;271(47):29734-9.
1996: Jeffrey A Frost; Shuichan Xu; Michele R Hutchison; Stevan Marcus; Melanie H Cobb
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members.
Molecular and cellular biology 1996;16(7):3707-13.
1996: Shuichan Xu; David J. Robbins; Lori B Christerson; Jessie M English; C A Vanderbilt; Melanie H Cobb
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5291-5.
1996: M Cheng; E Zhen; M J Robinson; D Ebert; Elizabeth J Goldsmith; Melanie H Cobb
Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3.
The Journal of biological chemistry 1996;271(20):12057-62.
1996: M J Robinson; P C Harkins; J Zhang; R Baer; J W Haycock; Melanie H Cobb; Elizabeth J Goldsmith
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry 1996;35(18):5641-6.
1996: M Cheng; T G Boulton; Melanie H Cobb
ERK3 is a constitutively nuclear protein kinase.
The Journal of biological chemistry 1996;271(15):8951-8.
1996: Melanie H Cobb; Shuichan Xu; M Cheng; D Ebert; David J. Robbins; Elizabeth J Goldsmith; M Robinson
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.
Advances in pharmacology (San Diego, Calif.) 1996;36():49-65.
1995: Jessie M English; C A Vanderbilt; Shuichan Xu; Stevan Marcus; Melanie H Cobb
Isolation of MEK5 and differential expression of alternatively spliced forms.
The Journal of biological chemistry 1995;270(48):28897-902.
1995: A Polverino; Jeffrey A Frost; Peirong Yang; Michele R Hutchison; A M Neiman; Melanie H Cobb; Stevan Marcus
Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.
The Journal of biological chemistry 1995;270(44):26067-70.
1995: Shuichan Xu; David J. Robbins; Jeffrey A Frost; A Dang; C Lange-Carter; Melanie H Cobb
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6808-12.
1995: Melanie H Cobb; Elizabeth J Goldsmith
How MAP kinases are regulated.
The Journal of biological chemistry 1995;270(25):14843-6.
1995: Stevan Marcus; A Polverino; E Chang; David J. Robbins; Melanie H Cobb; Michael Wigler
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6180-4.
1995: J Zhang; F Zhang; D Ebert; Melanie H Cobb; Elizabeth J Goldsmith
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.
Structure (London, England : 1993) 1995;3(3):299-307.
1994: G L James; Michael S Brown; Melanie H Cobb; Joseph L Goldstein
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
The Journal of biological chemistry 1994;269(44):27705-14.
1994: David J. Robbins; E Zhen; M Cheng; Shuichan Xu; D Ebert; Melanie H Cobb
MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.
Advances in cancer research 1994;63():93-116.
1994: Melanie H Cobb; Shuichan Xu; J E Hepler; Michele R Hutchison; Jeffrey A Frost; David J. Robbins
Regulation of the MAP kinase cascade.
Cellular & molecular biology research 1994;40(3):253-6.
1993: David J. Robbins; E Zhen; M Cheng; Shuichan Xu; C A Vanderbilt; D Ebert; C Garcia; A Dang; Melanie H Cobb
Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3.
Journal of the American Society of Nephrology : JASN 1993;4(5):1104-10.
1993: F Zhang; David J. Robbins; Melanie H Cobb; E J Goldsmith
Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag.
Journal of molecular biology 1993;233(3):550-2.
1993: David J. Robbins; E Zhen; H Owaki; C A Vanderbilt; D Ebert; TD Geppert; Melanie H Cobb
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.
The Journal of biological chemistry 1993;268(7):5097-106.
1993: J T Cheng; Melanie H Cobb; R Baer
Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.
Molecular and cellular biology 1993;13(2):801-8.
1992: David N Drechsel; Anthony A Hyman; Melanie H Cobb; Marc W Kirschner
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
Molecular biology of the cell 1992;3(10):1141-54.
1992: David J. Robbins; M Cheng; E Zhen; C A Vanderbilt; L A Feig; Melanie H Cobb
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6924-8.
1992: R Seger; Natalie G Ahn; J Posada; E S Munar; A M Jensen; Jonathan A Cooper; Melanie H Cobb; Edwin G Krebs
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
The Journal of biological chemistry 1992;267(20):14373-81.
1992: David J. Robbins; Melanie H Cobb
Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.
Molecular biology of the cell 1992;3(3):299-308.
1992: H Owaki; R Makar; T G Boulton; Melanie H Cobb; TD Geppert
Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
Biochemical and biophysical research communications 1992;182(3):1416-22.
1991: Melanie H Cobb; T G Boulton; David J. Robbins
Extracellular signal-regulated kinases: ERKs in progress.
Cell regulation 1991;2(12):965-78.
1991: Melanie H Cobb; David J. Robbins; T G Boulton
ERKs, extracellular signal-regulated MAP-2 kinases.
Current opinion in cell biology 1991;3(6):1025-32.
1991: J Rowles; C Slaughter; Carolyn Moomaw; J Hsu; Melanie H Cobb
Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9548-52.
1991: R Seger; Natalie G Ahn; T G Boulton; George D Yancopoulos; N Panayotatos; E Radziejewska; L Ericsson; R L Bratlien; Melanie H Cobb; Edwin G Krebs
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6142-6.
1991: T G Boulton; S H Nye; David J. Robbins; Nancy Y Ip; E Radziejewska; S D Morgenbesser; Ronald A DePinho; N Panayotatos; Melanie H Cobb; George D Yancopoulos
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Cell 1991;65(4):663-75.
1991: T G Boulton; Melanie H Cobb
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.
Cell regulation 1991;2(5):357-71.
1991: T G Boulton; J S Gregory; Melanie H Cobb
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase.
Biochemistry 1991;30(1):278-86.
1990: T G Boulton; George D Yancopoulos; J S Gregory; C Slaughter; Carolyn Moomaw; J Hsu; Melanie H Cobb
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control.
Science (New York, N.Y.) 1990;249(4964):64-7.
1990: T G Boulton; J S Gregory; S M Jong; L H Wang; L Ellis; Melanie H Cobb
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.
The Journal of biological chemistry 1990;265(5):2713-9.
1989: Melanie H Cobb; B C Sang; R Gonzalez; Elizabeth J Goldsmith; L Ellis
Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction.
The Journal of biological chemistry 1989;264(31):18701-6.
1989: J S Gregory; T G Boulton; B C Sang; Melanie H Cobb
An insulin-stimulated ribosomal protein S6 kinase from rabbit liver.
The Journal of biological chemistry 1989;264(31):18397-401.
1988: L Ellis; A Levitan; Melanie H Cobb; P Ramos
Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector.
Journal of virology 1988;62(5):1634-9.
1986: Melanie H Cobb; J G Burr; Maurine E Linder; T B Gray; J S Gregory
A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus.
Biochemical and biophysical research communications 1986;137(2):702-8.