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Moreno Cocchietto

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Marta Vadori; Francesca Vita; Sonia Zorzet; Moreno Cocchietto; Sabrina Pacor; Gianni Sava
Features and full reversibility of the renal toxicity of the ruthenium-based drug NAMI-A in mice.
Moreno Cocchietto; L Zorzin; B Toffoli; R Candido; B Fabris; M Stebel; G Sava
Orally administered microencapsulated lysozyme downregulates serum AGE and reduces the severity of early-stage diabetic nephropathy.
Moreno Cocchietto; Laura Zorzin; Paolo Alberto Veronesi; Gianni Sava
Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice.

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All Publications

2013: Marta Vadori; Francesca Vita; Sonia Zorzet; Moreno Cocchietto; Sabrina Pacor; Gianni Sava
Features and full reversibility of the renal toxicity of the ruthenium-based drug NAMI-A in mice.
Journal of inorganic biochemistry 2013;118():21-7.
2008: Moreno Cocchietto; L Zorzin; B Toffoli; R Candido; B Fabris; M Stebel; G Sava
Orally administered microencapsulated lysozyme downregulates serum AGE and reduces the severity of early-stage diabetic nephropathy.
Diabetes & metabolism 2008;34(6 Pt 1):587-94.
2008: Moreno Cocchietto; Laura Zorzin; Paolo Alberto Veronesi; Gianni Sava
Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice.
Molecular medicine reports 2008;1(6):847-50.
2007: Claudine Scolaro; Adrian B Chaplin; Christian G. Hartinger; Alberta Bergamo; Moreno Cocchietto; Bernhard K Keppler; Gianni Sava; Paul J Dyson
Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5065-72.
2006: Barbara Gava; Sonia Zorzet; Paola Spessotto; Moreno Cocchietto; Gianni Sava
Inhibition of B16 melanoma metastases with the ruthenium complex imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate and down-regulation of tumor cell invasion.
The Journal of pharmacology and experimental therapeutics 2006;317(1):284-91.
2005: Claudine Scolaro; Alberta Bergamo; Laura Brescacin; Riccarda Delfino; Moreno Cocchietto; Gábor Laurenczy; Tilmann J Geldbach; Gianni Sava; Paul J Dyson
In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes.
Journal of medicinal chemistry 2005;48(12):4161-71.
2005: Fabiana Frausin; Vito Scarcia; Moreno Cocchietto; Ariella Furlani; Barbara Serli; Enzo Alessio; Gianni Sava
Free exchange across cells, and echistatin-sensitive membrane target for the metastasis inhibitor NAMI-A (imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate) on KB tumor cells.
The Journal of pharmacology and experimental therapeutics 2005;313(1):227-33.
2004: Sabrina Pacor; Sonia Zorzet; Moreno Cocchietto; Marina Bacac; Marta Vadori; Claudia Turrin; Barbara Gava; Anna Castellarin; Gianni Sava
Intratumoral NAMI-A treatment triggers metastasis reduction, which correlates to CD44 regulation and tumor infiltrating lymphocyte recruitment.
The Journal of pharmacology and experimental therapeutics 2004;310(2):737-44.
2004: Gianni Sava; Fabiana Frausin; Moreno Cocchietto; Francesca Vita; Elena Podda; Paola Spessotto; Ariella Furlani; Vito Scarcia; Giuliano Zabucchi
Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A.
European journal of cancer (Oxford, England : 1990) 2004;40(9):1383-96.
2004: Aldrik H Velders; Alberta Bergamo; Enzo Alessio; Ennio Zangrando; Jaap G Haasnoot; Claudia Casarsa; Moreno Cocchietto; Sonia Zorzet; Gianni Sava
Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine).
Journal of medicinal chemistry 2004;47(5):1110-21.
2004: Alberta Bergamo; Gabriele Stocco; Claudia Casarsa; Moreno Cocchietto; Enzo Alessio; Barbara Serli; Sonia Zorzet; Gianni Sava
Reduction of in vivo lung metastases by dinuclear ruthenium complexes is coupled to inhibition of in vitro tumour invasion.
International journal of oncology 2004;24(2):373-9.
2003: Alberta Bergamo; Luigi Messori; Francesca Piccioli; Moreno Cocchietto; Gianni Sava
Biological role of adduct formation of the ruthenium(III) complex NAMI-A with serum albumin and serum transferrin.
Investigational new drugs 2003;21(4):401-11.
2003: Gianni Sava; Sonia Zorzet; Claudia Turrin; Francesca Vita; Maria Rosa Soranzo; Giuliano Zabucchi; Moreno Cocchietto; Alberta Bergamo; Stefano DiGiovine; Gabriella Pezzoni; Luigi Sartor; Spiridione Garbisa
Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1898-905.
2003: Alberta Bergamo; Gabriele Stocco; Barbara Gava; Moreno Cocchietto; Enzo Alessio; Barbara Serli; Elisabetta Iengo; Gianni Sava
Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines.
The Journal of pharmacology and experimental therapeutics 2003;305(2):725-32.
2003: Moreno Cocchietto; Sonia Zorzet; Alenka Sorc; Gianni Sava
Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration.
Investigational new drugs 2003;21(1):55-62.
2002: Alberta Bergamo; Barbara Gava; Enzo Alessio; Giovanni Mestroni; Barbara Serli; Moreno Cocchietto; Sonia Zorzet; Gianni Sava
Ruthenium-based NAMI-A type complexes with in vivo selective metastasis reduction and in vitro invasion inhibition unrelated to cell cytotoxicity.
International journal of oncology 2002;21(6):1331-8.
2002: Fabiana Frausin; Moreno Cocchietto; Alberta Bergamo; Vito Scarcia; Ariella Furlani; Gianni Sava
Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells.
Cancer chemotherapy and pharmacology 2002;50(5):405-11.
2002: Moreno Cocchietto; skert nicola; Pier Luigi Nimis; Gianni Sava
A review on usnic acid, an interesting natural compound.
Die Naturwissenschaften 2002;89(4):137-46.
2002: Gianni Sava; Alberta Bergamo; Sonia Zorzet; Barbara Gava; Claudia Casarsa; Moreno Cocchietto; Ariella Furlani; Vito Scarcia; Barbara Serli; Elisabetta Iengo; Enzo Alessio; Giovanni Mestroni
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A.
European journal of cancer (Oxford, England : 1990) 2002;38(3):427-35.
2001: Alberta Bergamo; Sonia Zorzet; Moreno Cocchietto; ME Carotenuto; Monica Magnarin; Gianni Sava
Tumour cell uptake G2-M accumulation and cytotoxicity of NAMI-A on TS/A adenocarcinoma cells.
Anticancer research 2001;21(3B):1893-8.
2001: Sonia Zorzet; A Sorc; Claudia Casarsa; Moreno Cocchietto; Gianni Sava
Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma.
Metal-based drugs 2001;8(1):1-7.
2000: Sonia Zorzet; Alberta Bergamo; Moreno Cocchietto; Alenka Sorc; Barbara Gava; Enzo Alessio; Elisabetta Iengo; Gianni Sava
Lack of In vitro cytotoxicity, associated to increased G(2)-M cell fraction and inhibition of matrigel invasion, may predict In vivo-selective antimetastasis activity of ruthenium complexes.
The Journal of pharmacology and experimental therapeutics 2000;295(3):927-33.
2000: Gianni Sava; Moreno Cocchietto
Blood levels of ruthenium following repeated treatments with the antimetastatic compound NAMI-A in healthy beagle dogs.
In vivo (Athens, Greece) 2000;14(6):741-4.
2000: Moreno Cocchietto; Gianni Sava
Blood concentration and toxicity of the antimetastasis agent NAMI-A following repeated intravenous treatment in mice.
Pharmacology & toxicology 2000;87(5):193-7.
2000: Moreno Cocchietto; G Salerno; Enzo Alessio; Giovanni Mestroni; Gianni Sava
Fate of the antimetastatic ruthenium complex ImH [trans-RuCl4(DMSO)Im] after acute i.v. treatment in mice.
Anticancer research 2000;20(1A):197-202.
1999: Gianni Sava; K Clerici; I Capozzi; Moreno Cocchietto; R Gagliardi; Enzo Alessio; Giovanni Mestroni; Alberto Perbellini
Reduction of lung metastasis by ImH[trans-RuCl4(DMSO)Im]: mechanism of the selective action investigated on mouse tumors.
Anti-cancer drugs 1999;10(1):129-38.
1998: I Capozzi; K Clerici; Moreno Cocchietto; G Salerno; Alberta Bergamo; Gianni Sava
Modification of cell cycle and viability of TLX5 lymphoma in vitro by sulfoxide-ruthenium compounds and cisplatin detected by flow cytometry.
Chemico-biological interactions 1998;113(1):51-64.
1998: Gianni Sava; R Gagliardi; Moreno Cocchietto; K Clerici; I Capozzi; M Marrella; Enzo Alessio; Giovanni Mestroni; R Milanino
Comparison of the effects of the antimetastatic compound ImH[trans-RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice.
Pathology oncology research : POR 1998;4(1):30-6.
1996: Gianni Sava; I Capozzi; Alberta Bergamo; R Gagliardi; Moreno Cocchietto; L Masiero; Maurizio Onisto; Enzo Alessio; Giovanni Mestroni; Spiridione Garbisa
Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex.
International journal of cancer. Journal international du cancer 1996;68(1):60-6.
1996: Alberta Bergamo; Moreno Cocchietto; I Capozzi; Giovanni Mestroni; Enzo Alessio; Gianni Sava
Treatment of residual metastases with Na[trans-RuCl4 (DMSO)lm] and ruthenium uptake by tumor cells.
Anti-cancer drugs 1996;7(6):697-702.
1996: Sabrina Pacor; E Giacomello; Alberta Bergamo; R Gagliardi; Moreno Cocchietto; Gianni Sava
Cytofluorimetric analysis of gut-intraepithelial and mesenteric lymph node lymphocytes of tumour bearing mice fed with egg-white lysozyme.
Anticancer research 1996;16(1):145-9.
1995: Gianni Sava; Sabrina Pacor; Alberta Bergamo; Moreno Cocchietto; Giovanni Mestroni; Enzo Alessio
Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition.
Chemico-biological interactions 1995;95(1-2):109-26.