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Donald Coen

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Natalia I Reim; Mayuri Sharma; Depeng Wang; Maria Ericsson; David E Golan; Jeremy P Kamil; Alison Lin; Jean M Pesola; Donald M Coen
Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.
Anna R Cliffe; Donald M Coen; David M Knipe
Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
Shariya L Terrell; Donald M Coen
The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.

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2013: Natalia I Reim; Mayuri Sharma; Depeng Wang; Maria Ericsson; David E Golan; Jeremy P Kamil; Alison Lin; Jean M Pesola; Donald M Coen
Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.
Journal of virology 2013;87(9):5019-27.
2013: Anna R Cliffe; Donald M Coen; David M Knipe
Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
mBio 2013;4(1):.
2012: Shariya L Terrell; Donald M Coen
The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.
Journal of virology 2012;86(20):11057-65.
2012: Blair L Strang; Brian J Bender; Jean M Pesola; Rebecca L Sanders; Mayuri Sharma; Deborah H Spector; Donald M Coen
A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.
Journal of virology 2012;86(20):11066-77.
2012: Dongli Pan; Donald M Coen
Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):14852-7.
2012: Sandra K Weller; Donald M Coen
Herpes simplex viruses: mechanisms of DNA replication.
Cold Spring Harbor perspectives in biology 2012;4(9):a013011.
2012: Igor Jurak; Mayuri Sharma; Leah B Silverstein; Donald M Coen
Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity.
Journal of virology 2012;86(18):10093-102.
2012: Blair L Strang; Tomas Kirchhausen; Steeve Boulant; Donald M Coen
Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.
mBio 2012;3(1):.
2011: Donald M Coen; Richard J Whitley
Antiviral drugs and antiviral drug resistance.
Current opinion in virology 2011;1(6):545-7.
2011: Igor Jurak; Anthony Griffiths; Donald M Coen
Mammalian alphaherpesvirus miRNAs.
Biochimica et biophysica acta 2011;1809(11-12):641-53.
2011: Martha F Kramer; Jean M Pesola; Sandrine Boissel; Igor Jurak; David M Knipe; Donald M Coen
Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.
Virology 2011;417(2):239-47.
2010: Laurie A Silva; Arianna Loregian; Gregory S Pari; Blair L Strang; Donald M Coen
The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.
Journal of virology 2010;84(21):11563-8.
2010: Blair L Strang; Adam P Geballe; Donald M Coen
Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44.
The Journal of general virology 2010;91(Pt 9):2167-75.
2010: Blair L Strang; Donald M Coen
Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54.
The Journal of general virology 2010;91(Pt 8):2029-33.
2010: Igor Jurak; Martha F Kramer; Joseph C Mellor; Alison L van Lint; Frederick P Roth; David M Knipe; Donald M Coen
Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.
Journal of virology 2010;84(9):4659-72.
2010: Blair L Strang; Steeve Boulant; Donald M Coen
Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.
Journal of virology 2010;84(4):1771-84.
2009: Jennifer L Baltz; David J Filman; Mihai Ciustea; Janice Elaine Y Silverman; Catherine L Lautenschlager; Donald M Coen; Robert P Ricciardi; James M Hogle
The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2009;83(23):12215-28.
2009: Jeremy P Kamil; Adam J Hume; Igor Jurak; Karl Münger; Robert F Kalejta; Donald M Coen
Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16823-8.
2009: Changying Jiang; Gloria Komazin-Meredith; Wang Tian; Donald M Coen; Charles B C Hwang
Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.
Journal of virology 2009;83(15):7573-80.
2009: Blair L Strang; Elisa Sinigalia; Laurie A Silva; Donald M Coen; Arianna Loregian
Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84.
Journal of virology 2009;83(15):7581-9.
2009: My D Sam; Brady T Evans; Donald M Coen; James M Hogle
Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex.
Journal of virology 2009;83(7):2996-3006.
2009: Sofia Hamirally; Jeremy P Kamil; Yasmine M Ndassa-Colday; Alison J Lin; Wan Jin Jahng; Moon-Chang Baek; Sarah Noton; Laurie A Silva; Martha Simpson-Holley; David M Knipe; David E Golan; Jarrod A Marto; Donald M Coen
Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.
PLoS pathogens 2009;5(1):e1000275.
2008: Elisa Sinigalia; Gualtiero Alvisi; Beatrice Mercorelli; Donald M Coen; Gregory S Pari; David A Jans; Alessandro Ripalti; Giorgio Palù; Arianna Loregian
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.
Journal of virology 2008;82(24):12574-9.
2008: Kevin F Bryant; Elizabeth R Macari; Natasha Malik; Michael Boyce; Junying Yuan; Donald M Coen
ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Virology 2008;379(2):197-204.
2008: Gloria Komazin-Meredith; Robert J Petrella; Webster L Santos; David J Filman; James M Hogle; Gregory L Verdine; Martin Karplus; Donald M Coen
The human cytomegalovirus UL44 C clamp wraps around DNA.
Structure (London, England : 1993) 2008;16(8):1214-25.
2008: Gloria Komazin-Meredith; Rossen Mirchev; David E Golan; Antoine M van Oijen; Donald M Coen
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10721-6.
2008: Gloria Komazin-Meredith; Webster L Santos; David J Filman; James M Hogle; Gregory L Verdine; Donald M Coen
The positively charged surface of herpes simplex virus UL42 mediates DNA binding.
The Journal of biological chemistry 2008;283(10):6154-61.
2008: Kevin F Bryant; Donald M Coen
Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript.
Journal of virology 2008;82(1):77-85.
2007: Changying Jiang; Ying T Hwang; Guangliang Wang; John C W Randell; Donald M Coen; Charles B C Hwang
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Journal of virology 2007;81(21):12077-9.
2007: Jeremy P Kamil; Donald M Coen
Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65.
Journal of virology 2007;81(19):10659-68.
2007: Allen W Dodson; Travis J Taylor; David M Knipe; Donald M Coen
Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Virology 2007;366(2):340-8.
2007: Michael I Besecker; Caroline L Furness; Donald M Coen; Anthony Griffiths
Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Journal of virology 2007;81(15):8356-60.
2007: Jean M Pesola; Donald M Coen
In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant.
The Journal of general virology 2007;88(Pt 5):1410-4.
2007: Changying Jiang; Ying T Hwang; John C W Randell; Donald M Coen; Charles B C Hwang
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Journal of virology 2007;81(7):3495-502.
2007: Arianna Loregian; Elisa Sinigalia; Beatrice Mercorelli; Giorgio Palù; Donald M Coen
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism.
Nucleic acids research 2007;35(14):4779-91.
2006: Martha F Kramer; Donald M Coen
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2006;Appendix 3():Appendix 3K.
2006: Anthony Griffiths; Malen A Link; Caroline L Furness; Donald M Coen
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
Journal of virology 2006;80(13):6568-74.
2006: Can Cui; Anthony Griffiths; Guanglin Li; Lindsey M Silva; Martha F Kramer; Terry Gaasterland; Xiu-Jie Wang; Donald M Coen
Prediction and identification of herpes simplex virus 1-encoded microRNAs.
Journal of virology 2006;80(11):5499-508.
2006: Benjamin Shogan; Lori Kruse; Gilbert B Mulamba; André Hu; Donald M Coen
Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.
Journal of virology 2006;80(10):4740-7.
2006: Brent A Appleton; Justin Brooks; Arianna Loregian; David J Filman; Donald M Coen; James M Hogle
Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
The Journal of biological chemistry 2006;281(8):5224-32.
2006: Arianna Loregian; Donald M Coen
Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase.
Chemistry & biology 2006;13(2):191-200.
2005: Jean M Pesola; Jia Zhu; David M Knipe; Donald M Coen
Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Journal of virology 2005;79(23):14516-25.
2005: Qing-Yin Wang; Changhong Zhou; Karen E Johnson; Robert C Colgrove; Donald M Coen; David M Knipe
Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16055-9.
2005: John C W Randell; Gloria Komazin; Changying Jiang; Charles B C Hwang; Donald M Coen
Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis.
Journal of virology 2005;79(18):12025-34.
2005: Anthony Griffiths; Donald M Coen
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9667-72.
2005: Michael Boyce; Kevin F Bryant; Céline Jousse; Kai Long; Heather P Harding; Donalyn Scheuner; Randal J Kaufman; Dawei Ma; Donald M Coen; David Ron; Junying Yuan
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: Kevin F Bryant; J Colin Cox; Hongming Wang; James M Hogle; Andrew D Ellington; Donald M Coen
Binding of herpes simplex virus-1 US11 to specific RNA sequences.
Nucleic acids research 2005;33(19):6090-100.
2004: Arianna Loregian; Brent A Appleton; James M Hogle; Donald M Coen
Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.
Journal of virology 2004;78(17):9084-92.
2004: Brent A Appleton; Arianna Loregian; David J Filman; Donald M Coen; James M Hogle
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.
Molecular cell 2004;15(2):233-44.
2004: Moon-Chang Baek; Paula M Krosky; Angela Pearson; Donald M Coen
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Virology 2004;324(1):184-93.
2004: Beatrice D Pilger; Can Cui; Donald M Coen
Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Chemistry & biology 2004;11(5):647-54.
2004: John C W Randell; Donald M Coen
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Journal of molecular biology 2004;335(2):409-13.
2004: W James Cook; Martha F Kramer; Russell M Walker; Timothy J Burwell; Holly Ann Holman; Donald M Coen; David M Knipe
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Virology journal 2004;1():5.
2004: Arianna Loregian; Brent A Appleton; James M Hogle; Donald M Coen
Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44.
Journal of virology 2004;78(1):158-67.
2004: Angela Pearson; David M Knipe; Donald M Coen
ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.
Journal of virology 2004;78(1):23-32.
2003: Martha F Kramer; W James Cook; Frederick P Roth; Jia Zhu; Holly Holman; David M Knipe; Donald M Coen
Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Journal of virology 2003;77(17):9533-41.
2003: Paula M Krosky; Moon-Chang Baek; Wan Jin Jahng; Imma Barrera; Robert J Harvey; Karen K Biron; Donald M Coen; Phiroze B Sethna
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.
Journal of virology 2003;77(14):7720-7.
2003: Donald M Coen; Priscilla A Schaffer
Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets.
Nature reviews. Drug discovery 2003;2(4):278-88.
2003: Anthony Griffiths; Shun-Hua Chen; Brian C Horsburgh; Donald M Coen
Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Journal of virology 2003;77(8):4703-9.
2003: Martha Kramer; Jennifer Riley; Amy Spoering; Donald M Coen; David M Knipe
Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Current eye research 2003;26(3-4):185-94.
2003: Anthony Griffiths; Donald M Coen
High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.
Journal of virology 2003;77(3):2282-6.
2003: Paula M Krosky; Moon-Chang Baek; Donald M Coen
The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.
Journal of virology 2003;77(2):905-14.
2002: Moon-Chang Baek; Paula M Krosky; Donald M Coen
Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase.
Journal of virology 2002;76(23):11943-52.
2002: Martha F Kramer; Donald M Coen
The polymerase chain reaction.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2002;Appendix 4():Appendix 4J.
2002: Angela Pearson; Donald M Coen
Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1.
Journal of virology 2002;76(21):10821-8.
2002: Moon-Chang Baek; Paula M Krosky; Zuwen He; Donald M Coen
Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position.
The Journal of biological chemistry 2002;277(33):29593-9.
2002: Shun-Hua Chen; Lily Yeh Lee; David A Garber; Priscilla A Schaffer; David M Knipe; Donald M Coen
Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 2002;76(10):4764-72.
2001: Donald M Coen
Quantitation of rare DNAs by PCR.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 15():Unit 15.7.
2001: Martha F Kramer; Donald M Coen
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 15():Unit 15.1.
2001: John C W Randell; Donald M Coen
Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor.
Molecular cell 2001;8(4):911-20.
2001: Kristie Bridges; C S Chow; Donald M Coen
Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.
Journal of virology 2001;75(11):4990-8.
2001: Martha F Kramer; Donald M Coen
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Appendix 3():A.3C.1-14.
2001: Martha F Kramer; Donald M Coen
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Appendix 3():Appendix 3F.
2001: J Burkham; Donald M Coen; Charles B C Hwang; Sandra K Weller
Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.
Journal of virology 2001;75(5):2353-67.
2000: Shun-Hua Chen; David A Garber; Priscilla A Schaffer; David M Knipe; Donald M Coen
Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Virology 2000;278(1):207-16.
2000: Harmon J Zuccola; David J Filman; Donald M Coen; James M Hogle
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Molecular cell 2000;5(2):267-78.
2000: Kristie Bridges; Q Hua; Michael Brigham-Burke; J D Martin; Preston Hensley; C E Dahl; P Digard; M A Weiss; Donald M Coen
Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase.
The Journal of biological chemistry 2000;275(1):472-8.
1999: Christine L Talarico; T C Burnette; Wayne H Miller; S L Smith; Michelle G Davis; Sylvia C Stanat; T I Ng; Z He; Donald M Coen; B Roizman; Karen K Biron
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Antimicrobial agents and chemotherapy 1999;43(8):1941-6.
1999: L Huang; K K Ishii; Harmon J Zuccola; AM Gehring; Charles B C Hwang; James M Hogle; Donald M Coen
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):447-52.
1999: K Weisshart; C S Chow; Donald M Coen
Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Journal of virology 1999;73(1):55-66.
1998: E Pelosi; F Rozenberg; Donald M Coen; K L Tyler
A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice.
Virology 1998;252(2):364-72.
1998: J Burkham; Donald M Coen; Sandra K Weller
ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.
Journal of virology 1998;72(12):10100-7.
1998: L E Hann; W James Cook; Susan L Uprichard; David M Knipe; Donald M Coen
The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.
Journal of virology 1998;72(10):7709-14.
1998: B C Horsburgh; Shun-Hua Chen; André Hu; Gilbert B Mulamba; W H Burns; Donald M Coen
Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?
The Journal of infectious diseases 1998;178(3):618-25.
1998: Shun-Hua Chen; W James Cook; K L Grove; Donald M Coen
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Journal of virology 1998;72(8):6710-5.
1998: Donald M Coen
The persistence of (HIV in) memory (T cells).
Trends in microbiology 1998;6(4):129-30.
1998: Gilbert B Mulamba; André Hu; R F Azad; K P Anderson; Donald M Coen
Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).
Antimicrobial agents and chemotherapy 1998;42(4):971-3.
1998: Jennie Jacobson; Shun-Hua Chen; W James Cook; Martha F Kramer; Donald M Coen
Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.
Virology 1998;242(1):161-9.
1998: Martha F Kramer; Shun-Hua Chen; David M Knipe; Donald M Coen
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Journal of virology 1998;72(2):1177-85.
1998: E Pelosi; Gilbert B Mulamba; Donald M Coen
Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.
Antiviral research 1998;37(1):17-28.
1997: Ying T Hwang; Bu-Yuan Liu; Donald M Coen; Charles B C Hwang
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Journal of virology 1997;71(10):7791-8.
1997: Shun-Hua Chen; Martha F Kramer; Priscilla A Schaffer; Donald M Coen
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 1997;71(8):5878-84.
1997: Z He; Y S He; Y Kim; L Chu; C Ohmstede; Karen K Biron; Donald M Coen
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
Journal of virology 1997;71(1):405-11.
1996: B C Horsburgh; H Kollmus; H Hauser; Donald M Coen
Translational recoding induced by G-rich mRNA sequences that form unusual structures.
Cell 1996;86(6):949-59.
1996: W James Cook; Donald M Coen
Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation.
Virology 1996;218(1):204-13.
1996: W James Cook; K K Wobbe; J Böni; Donald M Coen
Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene.
Virology 1996;218(1):193-203.
1996: Donald M Coen
Wheel keeps turning for antiviral combination chemotherapy.
Trends in microbiology 1996;4(2):51-2.
1996: Donald M Coen
Antiviral drug resistance in herpes simplex virus.
Advances in experimental medicine and biology 1996;394():49-57.
1995: W James Cook; S M Lin; Neal A DeLuca; Donald M Coen
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Journal of virology 1995;69(11):7291-4.
1995: C S Chow; Donald M Coen
Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42.
Journal of virology 1995;69(11):6965-71.
1995: W James Cook; B Gu; Neal A DeLuca; E B Moynihan; Donald M Coen
Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes.
Molecular and cellular biology 1995;15(9):4998-5006.
1995: Martha F Kramer; Donald M Coen
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 1995;69(3):1389-99.
1995: Paul Digard; K P Williams; P Hensley; Ian S. Brooks; C E Dahl; Donald M Coen
Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1456-60.
1995: J Jacobson; M Kramer; F Rozenberg; A Hu; Donald M Coen
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Virology 1995;206(1):263-8.
1995: Paul Digard; W R Bebrin; Donald M Coen
Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype.
Methods in enzymology 1995;262():303-22.
1994: Donald M Coen
Acyclovir-resistant, pathogenic herpesviruses.
Trends in microbiology 1994;2(12):481-5.
1994: K Weisshart; A A Kuo; Charles B C Hwang; K Kumura; Donald M Coen
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
The Journal of biological chemistry 1994;269(36):22788-96.
1994: Charles B C Hwang; B Horsburgh; E Pelosi; S Roberts; Paul Digard; Donald M Coen
A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5461-5.
1994: T Mineta; J M Markert; Y Takamiya; Donald M Coen; samuel rabkin; Robert L Martuza
CNS tumor therapy by attenuated herpes simplex viruses.
Gene therapy 1994;1 Suppl 1():S78.
1994: G Davar; Martha F Kramer; D Garber; A L Roca; J K Andersen; W Bebrin; Donald M Coen; M Kosz-Vnenchak; David M Knipe; Xandra O Breakefield
Gene transfer to sensory neurons using herpes virus vectors.
Gene therapy 1994;1 Suppl 1():S24.
1994: G Davar; Martha F Kramer; D Garber; A L Roca; J K Andersen; W Bebrin; Donald M Coen; M Kosz-Vnenchak; David M Knipe; Xandra O Breakefield
Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.
The Journal of comparative neurology 1994;339(1):3-11.
1993: W Cai; T L Astor; L M Liptak; C Cho; Donald M Coen; Priscilla A Schaffer
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
Journal of virology 1993;67(12):7501-12.
1993: Jennie Jacobson; K L Ruffner; M Kosz-Vnenchak; Charles B C Hwang; K K Wobbe; David M Knipe; Donald M Coen
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Journal of virology 1993;67(11):6903-8.
1993: D A Garber; Stephen M Beverley; Donald M Coen
Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis.
Virology 1993;197(1):459-62.
1993: K K Wobbe; Paul Digard; David Staknis; Donald M Coen
Unusual regulation of expression of the herpes simplex virus DNA polymerase gene.
Journal of virology 1993;67(9):5419-25.
1993: M Kosz-Vnenchak; J Jacobson; Donald M Coen; David M Knipe
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Journal of virology 1993;67(9):5383-93.
1993: J M Markert; A Malick; Donald M Coen; Robert L Martuza
Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.
Neurosurgery 1993;32(4):597-603.
1993: Paul Digard; C S Chow; L Pirrit; Donald M Coen
Functional analysis of the herpes simplex virus UL42 protein.
Journal of virology 1993;67(3):1159-68.
1993: K Weisshart; A A Kuo; G R Painter; L L Wright; P A Furman; Donald M Coen
Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1028-32.
1993: V Sullivan; Karen K Biron; Christine L Talarico; S C Stanat; M Davis; L M Pozzi; Donald M Coen
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.
Antimicrobial agents and chemotherapy 1993;37(1):19-25.
1993: Paul Digard; W R Bebrin; K Weisshart; Donald M Coen
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.
Journal of virology 1993;67(1):398-406.
1992: J M Markert; Donald M Coen; A Malick; T Mineta; Robert L Martuza
Expanded spectrum of viral therapy in the treatment of nervous system tumors.
Journal of neurosurgery 1992;77(4):590-4.
1992: V Sullivan; Christine L Talarico; S C Stanat; M Davis; Donald M Coen; Karen K Biron
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Nature 1992;359(6390):85.
1992: V Sullivan; Christine L Talarico; S C Stanat; M Davis; Donald M Coen; Karen K Biron
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Nature 1992;358(6382):162-4.
1992: Charles B C Hwang; K L Ruffner; Donald M Coen
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
Journal of virology 1992;66(3):1774-6.
1992: E Pelosi; K A Hicks; Stephen L Sacks; Donald M Coen
Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.
Advances in experimental medicine and biology 1992;312():151-8.
1991: V Sullivan; Donald M Coen
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.
The Journal of infectious diseases 1991;164(4):781-4.
1991: J S Gibbs; K Weisshart; Paul Digard; A deBruynKops; David M Knipe; Donald M Coen
Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Molecular and cellular biology 1991;11(9):4786-95.
1991: Robert L Martuza; A Malick; J M Markert; K L Ruffner; Donald M Coen
Experimental therapy of human glioma by means of a genetically engineered virus mutant.
Science (New York, N.Y.) 1991;252(5007):854-6.
1991: Donald M Coen
The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy.
Antiviral research 1991;15(4):287-300.
1991: M Bush; D R Yager; M Gao; K Weisshart; A I Marcy; Donald M Coen; David M Knipe
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Journal of virology 1991;65(3):1082-9.
1991: A N Imbalzano; Donald M Coen; Neal A DeLuca
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Journal of virology 1991;65(2):565-74.
1990: J Gottlieb; A I Marcy; Donald M Coen; M D Challberg
The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
Journal of virology 1990;64(12):5976-87.
1990: A I Marcy; Charles B C Hwang; K L Ruffner; Donald M Coen
Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
Journal of virology 1990;64(12):5883-90.
1990: M Kosz-Vnenchak; Donald M Coen; David M Knipe
Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.
Journal of virology 1990;64(11):5396-402.
1990: Paul Digard; Donald M Coen
A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein.
The Journal of biological chemistry 1990;265(29):17393-6.
1990: J P Katz; E T Bodin; Donald M Coen
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.
Journal of virology 1990;64(9):4288-95.
1990: D A Leib; K L Ruffner; C Hildebrand; Priscilla A Schaffer; G E Wright; Donald M Coen
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Antimicrobial agents and chemotherapy 1990;34(6):1285-6.
1990: A I Marcy; D R Yager; Donald M Coen
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Journal of virology 1990;64(5):2208-16.
1990: D R Yager; A I Marcy; Donald M Coen
Translational regulation of herpes simplex virus DNA polymerase.
Journal of virology 1990;64(5):2217-25.
1990: A I Marcy; Paul David Olivo; M D Challberg; Donald M Coen
Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Nucleic acids research 1990;18(5):1207-15.
1990: Donald M Coen
Antiviral drug resistance.
Annals of the New York Academy of Sciences 1990;616():224-37.
1989: Jennie Jacobson; D A Leib; D J Goldstein; C L Bogard; Priscilla A Schaffer; S K Weller; Donald M Coen
A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.
Virology 1989;173(1):276-83.
1989: J Böni; Donald M Coen
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Journal of virology 1989;63(9):4088-92.
1989: Donald M Coen; D J Goldstein; S K Weller
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
Antimicrobial agents and chemotherapy 1989;33(8):1395-9.
1989: D A Leib; C L Bogard; M Kosz-Vnenchak; K A Hicks; Donald M Coen; David M Knipe; Priscilla A Schaffer
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Journal of virology 1989;63(7):2893-900.
1989: Donald M Coen; M Kosz-Vnenchak; Jennie Jacobson; D A Leib; C L Bogard; Priscilla A Schaffer; Kenneth L Tyler; David M Knipe
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4736-40.
1989: Jennie Jacobson; S L Martin; Donald M Coen
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
Journal of virology 1989;63(4):1839-43.
1989: Donald M Coen; A F Irmiere; Jennie Jacobson; K M Kerns
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Virology 1989;168(2):221-31.
1989: A F Irmiere; M M Manos; Jennie Jacobson; J S Gibbs; Donald M Coen
Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability.
Virology 1989;168(2):210-20.
1989: D A Leib; Donald M Coen; C L Bogard; K A Hicks; D R Yager; David M Knipe; Kenneth L Tyler; Priscilla A Schaffer
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Journal of virology 1989;63(2):759-68.
1988: J S Gibbs; H C Chiou; Kenneth F Bastow; Y C Cheng; Donald M Coen
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6672-6.
1988: D R Yager; Donald M Coen
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Journal of virology 1988;62(6):2007-15.
1986: Karen K Biron; J A Fyfe; S C Stanat; L K Leslie; J B Sorrell; C U Lambe; Donald M Coen
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8769-73.
1986: H C Chiou; K M Kerns; Donald M Coen
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.
Antimicrobial agents and chemotherapy 1986;30(3):502-4.
1986: J D Hall; J S Gibbs; Donald M Coen; D W Mount
Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1.
DNA (Mary Ann Liebert, Inc.) 1986;5(4):281-8.
1985: J S Gibbs; H C Chiou; J D Hall; D W Mount; M J Retondo; Sandra K Weller; Donald M Coen
Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(23):7969-73.
1985: H C Chiou; Sandra K Weller; Donald M Coen
Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors.
Virology 1985;145(2):213-26.
1985: Donald M Coen; H E Fleming; L K Leslie; M J Retondo
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Journal of virology 1985;53(2):477-88.
1984: J D Hall; Donald M Coen; B L Fisher; M Weisslitz; S Randall; R E Almy; P T Gelep; P A Schaffer
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Virology 1984;132(1):26-37.
1984: Donald M Coen; D P Aschman; P T Gelep; M J Retondo; Sandra K Weller; P A Schaffer
Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.
Journal of virology 1984;49(1):236-47.
1983: Sandra K Weller; D P Aschman; W R Sacks; Donald M Coen; P A Schaffer
Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Virology 1983;130(2):290-305.
1983: Donald M Coen; P A Furman; D P Aschman; P A Schaffer
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.
Nucleic acids research 1983;11(15):5287-97.
1982: Donald M Coen; P A Furman; P T Gelep; P A Schaffer
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.
Journal of virology 1982;41(3):909-18.