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Donald Coen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

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Molecular Sequence Data

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Herpes Simplex

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Co-Publications
Name
22
Knipe, David
13
Kramer, Martha
12
Hwang, Charles
11
Hogle, James
10
Schaffer, Priscilla
9
Cook, James
8
Digard, Paul
8
Chen, Shun-Hua
8
Loregian, Arianna
7
Biron, Karen
7
Jacobson, Jennie
6
Baek, Moon-Chang
6
Filman, David
6
Weller, Sandra
5
Randell, John

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Publications

TOP 3
Baltz Jennifer L; Filman David J; Ciustea Mihai; Silverman Janice Elaine Y; Lautenschlager Catherine L; Coen Donald M; Ricciardi Robert P; Hogle James M
The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Kamil Jeremy P; Hume Adam J; Jurak Igor; Münger Karl; Kalejta Robert F; Coen Donald M
Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.
Jiang Changying; Komazin-Meredith Gloria; Tian Wang; Coen Donald M; Hwang Charles B C
Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.

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All Publications

2009: Baltz Jennifer L; Filman David J; Ciustea Mihai; Silverman Janice Elaine Y; Lautenschlager Catherine L; Coen Donald M; Ricciardi Robert P; Hogle James M
The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2009;83(23):12215-28.
2009: Kamil Jeremy P; Hume Adam J; Jurak Igor; Münger Karl; Kalejta Robert F; Coen Donald M
Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16823-8.
2009: Jiang Changying; Komazin-Meredith Gloria; Tian Wang; Coen Donald M; Hwang Charles B C
Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.
Journal of virology 2009;83(15):7573-80.
2009: Strang Blair L; Sinigalia Elisa; Silva Laurie A; Coen Donald M; Loregian Arianna
Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84.
Journal of virology 2009;83(15):7581-9.
2009: Sam My D; Evans Brady T; Coen Donald M; Hogle James M
Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex.
Journal of virology 2009;83(7):2996-3006.
2009: Hamirally Sofia; Kamil Jeremy P; Ndassa-Colday Yasmine M; Lin Alison J; Jahng Wan Jin; Baek Moon-Chang; Noton Sarah; Silva Laurie A; Simpson-Holley Martha; Knipe David M; Golan David E; Marto Jarrod A; Coen Donald M
Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.
PLoS pathogens 2009;5(1):e1000275.
2008: Sinigalia Elisa; Alvisi Gualtiero; Mercorelli Beatrice; Coen Donald M; Pari Gregory S; Jans David A; Ripalti Alessandro; Palù Giorgio; Loregian Arianna
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.
Journal of virology 2008;82(24):12574-9.
2008: Bryant Kevin F; Macari Elizabeth R; Malik Natasha; Boyce Michael; Yuan Junying; Coen Donald M
ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Virology 2008;379(2):197-204.
2008: Komazin-Meredith Gloria; Petrella Robert J; Santos Webster L; Filman David J; Hogle James M; Verdine Gregory L; Karplus Martin; Coen Donald M
The human cytomegalovirus UL44 C clamp wraps around DNA.
Structure (London, England : 1993) 2008;16(8):1214-25.
2008: Komazin-Meredith Gloria; Mirchev Rossen; Golan David E; van Oijen Antoine M; Coen Donald M
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10721-6.
2008: Komazin-Meredith Gloria; Santos Webster L; Filman David J; Hogle James M; Verdine Gregory L; Coen Donald M
The positively charged surface of herpes simplex virus UL42 mediates DNA binding.
The Journal of biological chemistry 2008;283(10):6154-61.
2008: Bryant Kevin F; Coen Donald M
Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript.
Journal of virology 2008;82(1):77-85.
2007: Jiang Changying; Hwang Ying T; Wang Guangliang; Randell John C W; Coen Donald M; Hwang Charles B C
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Journal of virology 2007;81(21):12077-9.
2007: Kamil Jeremy P; Coen Donald M
Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65.
Journal of virology 2007;81(19):10659-68.
2007: Dodson Allen W; Taylor Travis J; Knipe David M; Coen Donald M
Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Virology 2007;366(2):340-8.
2007: Besecker Michael I; Furness Caroline L; Coen Donald M; Griffiths Anthony
Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Journal of virology 2007;81(15):8356-60.
2007: Pesola Jean M; Coen Donald M
In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant.
The Journal of general virology 2007;88(Pt 5):1410-4.
2007: Jiang Changying; Hwang Ying T; Randell John C W; Coen Donald M; Hwang Charles B C
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Journal of virology 2007;81(7):3495-502.
2007: Loregian Arianna; Sinigalia Elisa; Mercorelli Beatrice; Palù Giorgio; Coen Donald M
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism.
Nucleic acids research 2007;35(14):4779-91.
2006: Kramer Martha F; Coen Donald M
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2006;Appendix 3():Appendix 3K.
2006: Griffiths Anthony; Link Malen A; Furness Caroline L; Coen Donald M
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
Journal of virology 2006;80(13):6568-74.
2006: Cui Can; Griffiths Anthony; Li Guanglin; Silva Lindsey M; Kramer Martha F; Gaasterland Terry; Wang Xiu-Jie; Coen Donald M
Prediction and identification of herpes simplex virus 1-encoded microRNAs.
Journal of virology 2006;80(11):5499-508.
2006: Shogan Benjamin; Kruse Lori; Mulamba Gilbert B; Hu André; Coen Donald M
Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.
Journal of virology 2006;80(10):4740-7.
2006: Loregian Arianna; Coen Donald M
Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase.
Chemistry & biology 2006;13(2):191-200.
2006: Appleton Brent A; Brooks Justin; Loregian Arianna; Filman David J; Coen Donald M; Hogle James M
Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
The Journal of biological chemistry 2006;281(8):5224-32.
2005: Pesola Jean M; Zhu Jia; Knipe David M; Coen Donald M
Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Journal of virology 2005;79(23):14516-25.
2005: Wang Qing-Yin; Zhou Changhong; Johnson Karen E; Colgrove Robert C; Coen Donald M; Knipe David M
Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16055-9.
2005: Randell John C W; Komazin Gloria; Jiang Changying; Hwang Charles B C; Coen Donald M
Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis.
Journal of virology 2005;79(18):12025-34.
2005: Griffiths Anthony; Coen Donald M
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9667-72.
2005: Boyce Michael; Bryant Kevin F; Jousse Céline; Long Kai; Harding Heather P; Scheuner Donalyn; Kaufman Randal J; Ma Dawei; Coen Donald M; Ron David; Yuan Junying
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: Bryant Kevin F; Cox J Colin; Wang Hongming; Hogle James M; Ellington Andrew D; Coen Donald M
Binding of herpes simplex virus-1 US11 to specific RNA sequences.
Nucleic acids research 2005;33(19):6090-100.
2004: Loregian Arianna; Appleton Brent A; Hogle James M; Coen Donald M
Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.
Journal of virology 2004;78(17):9084-92.
2004: Appleton Brent A; Loregian Arianna; Filman David J; Coen Donald M; Hogle James M
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.
Molecular cell 2004;15(2):233-44.
2004: Baek Moon-Chang; Krosky Paula M; Pearson Angela; Coen Donald M
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Virology 2004;324(1):184-93.
2004: Pilger Beatrice D; Cui Can; Coen Donald M
Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Chemistry & biology 2004;11(5):647-54.
2004: Randell John C W; Coen Donald M
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Journal of molecular biology 2004;335(2):409-13.
2004: Loregian Arianna; Appleton Brent A; Hogle James M; Coen Donald M
Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44.
Journal of virology 2004;78(1):158-67.
2004: Pearson Angela; Knipe David M; Coen Donald M
ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.
Journal of virology 2004;78(1):23-32.
2004: Cook W James; Kramer Martha F; Walker Russell M; Burwell Timothy J; Holman Holly A; Coen Donald M; Knipe David M
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Virology journal 2004;1():5.
2003: Kramer Martha F; Cook W James; Roth Frederick P; Zhu Jia; Holman Holly; Knipe David M; Coen Donald M
Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Journal of virology 2003;77(17):9533-41.
2003: Krosky Paula M; Baek Moon-Chang; Jahng Wan Jin; Barrera Imma; Harvey Robert J; Biron Karen K; Coen Donald M; Sethna Phiroze B
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.
Journal of virology 2003;77(14):7720-7.
2003: Coen Donald M; Schaffer Priscilla A
Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets.
Nature reviews. Drug discovery 2003;2(4):278-88.
2003: Griffiths Anthony; Chen Shun-Hua; Horsburgh Brian C; Coen Donald M
Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Journal of virology 2003;77(8):4703-9.
2003: Kramer Martha; Riley Jennifer; Spoering Amy; Coen Donald; Knipe David
Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Current eye research 2003;26(3-4):185-94.
2003: Griffiths Anthony; Coen Donald M
High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.
Journal of virology 2003;77(3):2282-6.
2003: Krosky Paula M; Baek Moon-Chang; Coen Donald M
The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.
Journal of virology 2003;77(2):905-14.
2002: Baek Moon-Chang; Krosky Paula M; Coen Donald M
Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase.
Journal of virology 2002;76(23):11943-52.
2002: Kramer Martha F; Coen Donald M
The polymerase chain reaction.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2002;Appendix 4():Appendix 4J.
2002: Pearson Angela; Coen Donald M
Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1.
Journal of virology 2002;76(21):10821-8.
2002: Baek Moon-Chang; Krosky Paula M; He Zuwen; Coen Donald M
Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position.
The Journal of biological chemistry 2002;277(33):29593-9.
2002: Chen Shun-Hua; Lee Lily Yeh; Garber David A; Schaffer Priscilla A; Knipe David M; Coen Donald M
Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 2002;76(10):4764-72.
2001: Coen D M
Quantitation of rare DNAs by PCR.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 15():Unit 15.7.
2001: Kramer M F; Coen D M
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 15():Unit 15.1.
2001: Randell J C; Coen D M
Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor.
Molecular cell 2001;8(4):911-20.
2001: Bridges K G; Chow C S; Coen D M
Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.
Journal of virology 2001;75(11):4990-8.
2001: Kramer M F; Coen D M
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Appendix 3():Appendix 3F.
2001: Burkham J; Coen D M; Hwang C B; Weller S K
Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.
Journal of virology 2001;75(5):2353-67.
2000: Chen S H; Garber D A; Schaffer P A; Knipe D M; Coen D M
Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Virology 2000;278(1):207-16.
2000: Zuccola H J; Filman D J; Coen D M; Hogle J M
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Molecular cell 2000;5(2):267-78.
2000: Bridges K G; Hua Q; Brigham-Burke M R; Martin J D; Hensley P; Dahl C E; Digard P; Weiss M A; Coen D M
Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase.
The Journal of biological chemistry 2000;275(1):472-8.
1999: Talarico C L; Burnette T C; Miller W H; Smith S L; Davis M G; Stanat S C; Ng T I; He Z; Coen D M; Roizman B; Biron K K
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Antimicrobial agents and chemotherapy 1999;43(8):1941-6.
1999: Huang L; Ishii K K; Zuccola H; Gehring A M; Hwang C B; Hogle J; Coen D M
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):447-52.
1999: Weisshart K; Chow C S; Coen D M
Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Journal of virology 1999;73(1):55-66.
1998: Pelosi E; Rozenberg F; Coen D M; Tyler K L
A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice.
Virology 1998;252(2):364-72.
1998: Burkham J; Coen D M; Weller S K
ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.
Journal of virology 1998;72(12):10100-7.
1998: Hann L E; Cook W J; Uprichard S L; Knipe D M; Coen D M
The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.
Journal of virology 1998;72(10):7709-14.
1998: Horsburgh B C; Chen S H; Hu A; Mulamba G B; Burns W H; Coen D M
Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?
The Journal of infectious diseases 1998;178(3):618-25.
1998: Chen S H; Cook W J; Grove K L; Coen D M
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Journal of virology 1998;72(8):6710-5.
1998: Coen D M
The persistence of (HIV in) memory (T cells).
Trends in microbiology 1998;6(4):129-30.
1998: Mulamba G B; Hu A; Azad R F; Anderson K P; Coen D M
Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).
Antimicrobial agents and chemotherapy 1998;42(4):971-3.
1998: Jacobson J G; Chen S H; Cook W J; Kramer M F; Coen D M
Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.
Virology 1998;242(1):161-9.
1998: Kramer M F; Chen S H; Knipe D M; Coen D M
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Journal of virology 1998;72(2):1177-85.
1998: Pelosi E; Mulamba G B; Coen D M
Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.
Antiviral research 1998;37(1):17-28.
1997: Hwang Y T; Liu B Y; Coen D M; Hwang C B
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Journal of virology 1997;71(10):7791-8.
1997: Chen S H; Kramer M F; Schaffer P A; Coen D M
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 1997;71(8):5878-84.
1997: He Z; He Y S; Kim Y; Chu L; Ohmstede C; Biron K K; Coen D M
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
Journal of virology 1997;71(1):405-11.
1996: Horsburgh B C; Kollmus H; Hauser H; Coen D M
Translational recoding induced by G-rich mRNA sequences that form unusual structures.
Cell 1996;86(6):949-59.
1996: Cook W J; Coen D M
Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation.
Virology 1996;218(1):204-13.
1996: Cook W J; Wobbe K K; Böni J; Coen D M
Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene.
Virology 1996;218(1):193-203.
1996: Coen D M
Wheel keeps turning for antiviral combination chemotherapy.
Trends in microbiology 1996;4(2):51-2.
1996: Coen D M
Antiviral drug resistance in herpes simplex virus.
Advances in experimental medicine and biology 1996;394():49-57.
1995: Cook W J; Lin S M; DeLuca N A; Coen D M
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Journal of virology 1995;69(11):7291-4.
1995: Chow C S; Coen D M
Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42.
Journal of virology 1995;69(11):6965-71.
1995: Cook W J; Gu B; DeLuca N A; Moynihan E B; Coen D M
Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes.
Molecular and cellular biology 1995;15(9):4998-5006.
1995: Kramer M F; Coen D M
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Journal of virology 1995;69(3):1389-99.
1995: Digard P; Williams K P; Hensley P; Brooks I S; Dahl C E; Coen D M
Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1456-60.
1995: Jacobson J; Kramer M; Rozenberg F; Hu A; Coen D M
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Virology 1995;206(1):263-8.
1995: Digard P; Bebrin W R; Coen D M
Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype.
Methods in enzymology 1995;262():303-22.
1994: Coen D M
Acyclovir-resistant, pathogenic herpesviruses.
Trends in microbiology 1994;2(12):481-5.
1994: Weisshart K; Kuo A A; Hwang C B; Kumura K; Coen D M
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
The Journal of biological chemistry 1994;269(36):22788-96.
1994: Hwang C B; Horsburgh B; Pelosi E; Roberts S; Digard P; Coen D M
A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5461-5.
1994: Davar G; Kramer M F; Garber D; Roca A L; Andersen J K; Bebrin W; Coen D M; Kosz-Vnenchak M; Knipe D M; Breakefield X O
Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.
The Journal of comparative neurology 1994;339(1):3-11.
1994: Mineta T; Markert J M; Takamiya Y; Coen D M; Rabkin S D; Martuza R L
CNS tumor therapy by attenuated herpes simplex viruses.
Gene therapy 1994;1 Suppl 1():S78.
1994: Davar G; Kramer M F; Garber D; Roca A L; Andersen J K; Bebrin W; Coen D M; Kosz-Vnenchak M; Knipe D M; Breakefield X O
Gene transfer to sensory neurons using herpes virus vectors.
Gene therapy 1994;1 Suppl 1():S24.
1993: Cai W; Astor T L; Liptak L M; Cho C; Coen D M; Schaffer P A
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
Journal of virology 1993;67(12):7501-12.
1993: Jacobson J G; Ruffner K L; Kosz-Vnenchak M; Hwang C B; Wobbe K K; Knipe D M; Coen D M
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Journal of virology 1993;67(11):6903-8.
1993: Garber D A; Beverley S M; Coen D M
Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis.
Virology 1993;197(1):459-62.
1993: Wobbe K K; Digard P; Staknis D; Coen D M
Unusual regulation of expression of the herpes simplex virus DNA polymerase gene.
Journal of virology 1993;67(9):5419-25.
1993: Kosz-Vnenchak M; Jacobson J; Coen D M; Knipe D M
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Journal of virology 1993;67(9):5383-93.
1993: Markert J M; Malick A; Coen D M; Martuza R L
Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.
Neurosurgery 1993;32(4):597-603.
1993: Digard P; Chow C S; Pirrit L; Coen D M
Functional analysis of the herpes simplex virus UL42 protein.
Journal of virology 1993;67(3):1159-68.
1993: Weisshart K; Kuo A A; Painter G R; Wright L L; Furman P A; Coen D M
Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1028-32.
1993: Sullivan V; Biron K K; Talarico C; Stanat S C; Davis M; Pozzi L M; Coen D M
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.
Antimicrobial agents and chemotherapy 1993;37(1):19-25.
1993: Digard P; Bebrin W R; Weisshart K; Coen D M
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.
Journal of virology 1993;67(1):398-406.
1992: Markert J M; Coen D M; Malick A; Mineta T; Martuza R L
Expanded spectrum of viral therapy in the treatment of nervous system tumors.
Journal of neurosurgery 1992;77(4):590-4.
1992: Sullivan V; Talarico C L; Stanat S C; Davis M; Coen D M; Biron K K
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Nature 1992;359(6390):85.
1992: Sullivan V; Talarico C L; Stanat S C; Davis M; Coen D M; Biron K K
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Nature 1992;358(6382):162-4.
1992: Hwang C B; Ruffner K L; Coen D M
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
Journal of virology 1992;66(3):1774-6.
1992: Pelosi E; Hicks K A; Sacks S L; Coen D M
Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.
Advances in experimental medicine and biology 1992;312():151-8.
1991: Sullivan V; Coen D M
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.
The Journal of infectious diseases 1991;164(4):781-4.
1991: Gibbs J S; Weisshart K; Digard P; deBruynKops A; Knipe D M; Coen D M
Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Molecular and cellular biology 1991;11(9):4786-95.
1991: Martuza R L; Malick A; Markert J M; Ruffner K L; Coen D M
Experimental therapy of human glioma by means of a genetically engineered virus mutant.
Science (New York, N.Y.) 1991;252(5007):854-6.
1991: Coen D M
The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy.
Antiviral research 1991;15(4):287-300.
1991: Bush M; Yager D R; Gao M; Weisshart K; Marcy A I; Coen D M; Knipe D M
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Journal of virology 1991;65(3):1082-9.
1991: Imbalzano A N; Coen D M; DeLuca N A
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Journal of virology 1991;65(2):565-74.
1990: Gottlieb J; Marcy A I; Coen D M; Challberg M D
The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
Journal of virology 1990;64(12):5976-87.
1990: Marcy A I; Hwang C B; Ruffner K L; Coen D M
Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
Journal of virology 1990;64(12):5883-90.
1990: Kosz-Vnenchak M; Coen D M; Knipe D M
Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.
Journal of virology 1990;64(11):5396-402.
1990: Digard P; Coen D M
A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein.
The Journal of biological chemistry 1990;265(29):17393-6.
1990: Katz J P; Bodin E T; Coen D M
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.
Journal of virology 1990;64(9):4288-95.
1990: Leib D A; Ruffner K L; Hildebrand C; Schaffer P A; Wright G E; Coen D M
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Antimicrobial agents and chemotherapy 1990;34(6):1285-6.
1990: Marcy A I; Yager D R; Coen D M
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Journal of virology 1990;64(5):2208-16.
1990: Yager D R; Marcy A I; Coen D M
Translational regulation of herpes simplex virus DNA polymerase.
Journal of virology 1990;64(5):2217-25.
1990: Marcy A I; Olivo P D; Challberg M D; Coen D M
Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Nucleic acids research 1990;18(5):1207-15.
1990: Coen D M
Antiviral drug resistance.
Annals of the New York Academy of Sciences 1990;616():224-37.
1989: Jacobson J G; Leib D A; Goldstein D J; Bogard C L; Schaffer P A; Weller S K; Coen D M
A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.
Virology 1989;173(1):276-83.
1989: Böni J; Coen D M
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Journal of virology 1989;63(9):4088-92.
1989: Coen D M; Goldstein D J; Weller S K
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
Antimicrobial agents and chemotherapy 1989;33(8):1395-9.
1989: Leib D A; Bogard C L; Kosz-Vnenchak M; Hicks K A; Coen D M; Knipe D M; Schaffer P A
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Journal of virology 1989;63(7):2893-900.
1989: Coen D M; Kosz-Vnenchak M; Jacobson J G; Leib D A; Bogard C L; Schaffer P A; Tyler K L; Knipe D M
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4736-40.
1989: Jacobson J G; Martin S L; Coen D M
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
Journal of virology 1989;63(4):1839-43.
1989: Coen D M; Irmiere A F; Jacobson J G; Kerns K M
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Virology 1989;168(2):221-31.
1989: Irmiere A F; Manos M M; Jacobson J G; Gibbs J S; Coen D M
Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability.
Virology 1989;168(2):210-20.
1989: Leib D A; Coen D M; Bogard C L; Hicks K A; Yager D R; Knipe D M; Tyler K L; Schaffer P A
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Journal of virology 1989;63(2):759-68.
1988: Gibbs J S; Chiou H C; Bastow K F; Cheng Y C; Coen D M
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6672-6.
1988: Yager D R; Coen D M
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Journal of virology 1988;62(6):2007-15.
1986: Biron K K; Fyfe J A; Stanat S C; Leslie L K; Sorrell J B; Lambe C U; Coen D M
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8769-73.
1986: Chiou H C; Kerns K M; Coen D M
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.
Antimicrobial agents and chemotherapy 1986;30(3):502-4.
1986: Hall J D; Gibbs J S; Coen D M; Mount D W
Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1.
DNA (Mary Ann Liebert, Inc.) 1986;5(4):281-8.
1985: Gibbs J S; Chiou H C; Hall J D; Mount D W; Retondo M J; Weller S K; Coen D M
Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(23):7969-73.
1985: Chiou H C; Weller S K; Coen D M
Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors.
Virology 1985;145(2):213-26.
1985: Coen D M; Fleming H E; Leslie L K; Retondo M J
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Journal of virology 1985;53(2):477-88.
1984: Hall J D; Coen D M; Fisher B L; Weisslitz M; Randall S; Almy R E; Gelep P T; Schaffer P A
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Virology 1984;132(1):26-37.
1984: Coen D M; Aschman D P; Gelep P T; Retondo M J; Weller S K; Schaffer P A
Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.
Journal of virology 1984;49(1):236-47.
1983: Weller S K; Aschman D P; Sacks W R; Coen D M; Schaffer P A
Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Virology 1983;130(2):290-305.
1983: Coen D M; Furman P A; Aschman D P; Schaffer P A
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.
Nucleic acids research 1983;11(15):5287-97.
1982: Coen D M; Furman P A; Gelep P T; Schaffer P A
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.
Journal of virology 1982;41(3):909-18.

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