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Paul Coffer

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Tessa A M Steevels; Kristof van Avondt; Jona Walk; Geertje H A Westerlaken; Louis Bont; Paul J Coffer; Femke Stalpers; Linde Meyaard
Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes.
Ismayil Tasdelen; Olivier van Beekum; Niels J F van den Broek; Arjen Koppen; Ruud Berger; Arjan B Brenkman; Paul J Coffer; Veerle Fleskens; Olena Gorbenko; Nicole Hamers; Eric Kalkhoven
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.
Dietmar M W Zaiss; Paul M P van Bergen en Henegouwen; Jorg van Loosdregt; Cornelis P J Bekker; Paul J Coffer; Andrea Gorlani; Andrea Gröne; Rob C Roovers; Maria Sibilia; Alice J A M Sijts
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.

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All Publications

2013: Tessa A M Steevels; Kristof van Avondt; Jona Walk; Geertje H A Westerlaken; Louis Bont; Paul J Coffer; Femke Stalpers; Linde Meyaard
Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes.
European journal of immunology 2013;43(5):1297-308.
2013: Ismayil Tasdelen; Olivier van Beekum; Niels J F van den Broek; Arjen Koppen; Ruud Berger; Arjan B Brenkman; Paul J Coffer; Veerle Fleskens; Olena Gorbenko; Nicole Hamers; Eric Kalkhoven
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.
The Biochemical journal 2013;451(1):45-53.
2013: Dietmar M W Zaiss; Paul M P van Bergen en Henegouwen; Jorg van Loosdregt; Cornelis P J Bekker; Paul J Coffer; Andrea Gorlani; Andrea Gröne; Rob C Roovers; Maria Sibilia; Alice J A M Sijts
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Immunity 2013;38(2):275-84.
2013: Stephin J Vervoort; Ana Rita Lourenço; Ria van Boxtel; Paul J Coffer
SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.
PloS one 2013;8(1):e53238.
2012: Marije Bartels; Marc B Bierings; Paul J Coffer; Hanneke J den Breeijen; Wouter W van Solinge; Toine C G Egberts
Valproic acid treatment is associated with altered leukocyte subset development.
Journal of clinical psychopharmacology 2012;32(6):832-4.
2012: Kristan E van der Vos; Iris J van Zutphen; Liesbeth P Verhagen; Stephin J Vervoort; Sebastian Zellmer; A Koen Braat; Boudewijn M T Burgering; Tobias B Dansen; Pernilla Eliasson; Rolf Gebhardt; Marian J A Groot Koerkamp; Frank C P Holstege; Mario Mauthe; CM Pals; Tassula Proikas-Cezanne; Marrit Putker; Ruben van Boxtel; Paul J Coffer
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
Nature cell biology 2012;14(8):829-37.
2012: J M Beekman; A K Braat; A Brugulat-Panès; F Dekkers; J van Loosdregt; M E van Vessem; S Vendelbosch; S J Vervoort; Paul J Coffer
Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output.
Oncogene 2012;31(21):2668-79.
2012: Lianne van de Laar; Paul J Coffer; Andrea M Woltman
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy.
Blood 2012;119(15):3383-93.
2012: Gepke Visser; Frits A Wijburg; Paul J Coffer; Wilco de Jager; Berent J Prakken; G Peter A Smit; Liesbeth P Verhagen; Miranda Buitenhuis
Survival, but not maturation, is affected in neutrophil progenitors from GSD-1b patients.
Journal of inherited metabolic disease 2012;35(2):287-300.
2012: Petrus De Jong; Jeffrey M Beekman; Paul J Coffer; Berent J Prakken; Alvin W L Schadenberg; Theo van den Broek; Femke van Wijk; Nicolaas J G Jansen
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.
PloS one 2012;7(4):e35070.
2011: Lianne van de Laar; Aniek van den Bosch; Albertus T J Wierenga; Paul J Coffer; Harry L A Janssen; Andrea M Woltman
Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):7016-24.
2011: Kristan E van der Vos; Paul J Coffer
The extending network of FOXO transcriptional target genes.
Antioxidants & redox signaling 2011;14(4):579-92.
2011: Jorg van Loosdregt; Diede Brunen; Veerle Fleskens; Cornelieke E G M Pals; Eric W-F Lam; Paul J Coffer
Rapid temporal control of Foxp3 protein degradation by sirtuin-1.
PloS one 2011;6(4):e19047.
2010: Lianne van de Laar; Aniek van den Bosch; Sandra W van der Kooij; Harry L A Janssen; Paul J Coffer; Cees van Kooten; Andrea M Woltman
A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7252-61.
2010: Tessa A M Steevels; Geertje H A Westerlaken; Marloes R Tijssen; Paul J Coffer; Peter J Lenting; Jan-Willem N Akkerman; Linde Meyaard
Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts.
Haematologica 2010;95(12):2005-12.
2010: Miranda Buitenhuis; Edwin van der Linden; Laurien H Ulfman; Frans M Hofhuis; Marc Bierings; Paul J Coffer
Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties.
Blood 2010;116(13):2373-84.
2010: Jantine E Bakema; Ida H Hiemstra; Johanna Bakker; Simone de Haij; Yvonne Kok; Gosse Adema; Marjolein van Egmond; Paul J Coffer; Jan G J van de Winkel; Jeanette Leusen
c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain.
European journal of immunology 2010;40(7):2035-40.
2010: Marije Bartels; Christian R Geest; Marc Bierings; Miranda Buitenhuis; Paul J Coffer
Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation.
Haematologica 2010;95(7):1052-60.
2010: Lianne van de Laar; Miranda Buitenhuis; Felix M Wensveen; Harry L A Janssen; Paul J Coffer; Andrea M Woltman
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):6600-11.
2010: Jorg van Loosdregt; Yvonne Vercoulen; Teun Guichelaar; Yoony Y J Gent; Jeffrey M Beekman; Olivier van Beekum; Arjan B Brenkman; Dirk Hijnen; Tuna Mutis; Eric Kalkhoven; Berent J Prakken; Paul J Coffer
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
Blood 2010;115(5):965-74.
2009: Jeffrey M Beekman; Liesbeth P Verhagen; Niels Geijsen; Paul J Coffer
Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output.
Blood 2009;114(18):3917-27.
2009: Christian R Geest; Miranda Buitenhuis; Marian J A Groot Koerkamp; Frank C P Holstege; Edo Vellenga; Paul J Coffer
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors.
Blood 2009;114(16):3402-12.
2009: Wilco de Jager; Sebastiaan J Vastert; Jeffrey M Beekman; Nico M Wulffraat; Wietse Kuis; Paul J Coffer; Berent J Prakken
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.
Arthritis and rheumatism 2009;60(9):2782-93.
2009: Christian R Geest; Miranda Buitenhuis; Annemieke G Laarhoven; Marc Bierings; Marrie C A Bruin; Edo Vellenga; Paul J Coffer
p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21.
Stem cells (Dayton, Ohio) 2009;27(9):2271-82.
2009: Christian R Geest; Miranda Buitenhuis; Edo Vellenga; Paul J Coffer
Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia.
Haematologica 2009;94(8):1075-84.
2009: Christian R Geest; Paul J Coffer
MAPK signaling pathways in the regulation of hematopoiesis.
Journal of leukocyte biology 2009;86(2):237-50.
2009: Paul J Coffer
When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction.
Cell research 2009;19(7):797-9.
2009: Miranda Buitenhuis; Paul J Coffer
The role of the PI3K-PKB signaling module in regulation of hematopoiesis.
Cell cycle (Georgetown, Tex.) 2009;8(4):560-6.
2009: A G M van Gorp; K E van der Vos; Arjan B Brenkman; A Bremer; N van den Broek; Fried J T Zwartkruis; J W Hershey; Boudewijn M T Burgering; C F Calkhoven; Paul J Coffer
AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.
Oncogene 2009;28(1):95-106.
2008: Loes M Kuijk; Jeffrey M Beekman; Janet Koster; Hans R Waterham; Joost Frenkel; Paul J Coffer
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation.
Blood 2008;112(9):3563-73.
2008: Jeffrey M Beekman; Paul J Coffer
The ins and outs of syntenin, a multifunctional intracellular adaptor protein.
Journal of cell science 2008;121(Pt 9):1349-55.
2008: K E van der Vos; Paul J Coffer
FOXO-binding partners: it takes two to tango.
Oncogene 2008;27(16):2289-99.
2008: Loes M Kuijk; Saskia H L Mandey; Ingrid Schellens; Hans R Waterham; Ger T Rijkers; Paul J Coffer; Joost Frenkel
Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1.
Molecular immunology 2008;45(8):2158-65.
2008: Gwenny M Fuhler; A Lyndsay Drayer; Sandra G M Olthof; Jan Jacob Schuringa; Paul J Coffer; Edo Vellenga
Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia.
Blood 2008;111(1):359-68.
2008: Miranda Buitenhuis; Liesbeth P Verhagen; Hanneke W M van Deutekom; Anders Castor; Sandra Verploegen; Leo Koenderman; Sten Eirik W Jacobsen; Paul J Coffer
Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis.
Blood 2008;111(1):112-21.
2007: Miranda Buitenhuis; Liesbeth P Verhagen; Jan Cools; Paul J Coffer
Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation.
Cancer research 2007;67(8):3759-66.
2007: Paul J Coffer; Boudewijn M T Burgering
Stressed marrow: FoxOs stem tumour growth.
Nature cell biology 2007;9(3):251-3.
2007: Gwenny M Fuhler; Nel R Blom; Paul J Coffer; A Lyndsay Drayer; Edo Vellenga
The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation.
Journal of leukocyte biology 2007;81(2):449-57.
2007: Kim U Birkenkamp; Abdelkader Essafi; Kristan E van der Vos; Marco da Costa; Rosaline C-Y Hui; Frank Holstege; Leo Koenderman; Eric W-F Lam; Paul J Coffer
FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1.
The Journal of biological chemistry 2007;282(4):2211-20.
2006: Ankie G M van Gorp; Karen M Pomeranz; Kim U Birkenkamp; Rosaline C-Y Hui; Eric W-F Lam; Paul J Coffer
Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation.
Cancer research 2006;66(22):10760-9.
2006: Marcela Rosas; Pascale F Dijkers; Caroline L Lindemans; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization.
Journal of leukocyte biology 2006;80(1):186-95.
2006: Caroline A Lindemans; Paul J Coffer; Ingrid M M Schellens; Patricia M A De Graaff; Jan L L Kimpen; Leo Koenderman
Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5529-37.
2006: Annelies Verbrugge; Talitha Eshuis - de Ruiter; Christian Geest; Paul J Coffer; Linde Meyaard
Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation.
Journal of leukocyte biology 2006;79(4):828-36.
2005: Pedro J Real; Adalberto Benito; Jorge Cuevas; María T Berciano; Ana de Juan; Paul J Coffer; Javier Gomez-Roman; Miguel Lafarga; Jose M Lopez-Vega; Jose L Fernandez-Luna
Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L.
Cancer research 2005;65(18):8151-7.
2005: Sandra Verploegen; Laurien H Ulfman; Hanneke W M van Deutekom; Corneli W van Aalst; Henk Honing; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function.
Blood 2005;106(3):1076-83.
2005: Miranda Buitenhuis; Hanneke W M van Deutekom; Liesbeth P Verhagen; Anders Castor; Sten Eirik W Jacobsen; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2.
Blood 2005;105(11):4272-81.
2005: Jun-Wei Liu; Dhyan Chandra; Michael D Rudd; Andrew Butler; Vincent Pallotta; David Brown; Paul J Coffer; Ding "Dean" G. Tang
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS.
Oncogene 2005;24(12):2020-31.
2005: Marcela Rosas; Kim U Birkenkamp; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression.
FEBS letters 2005;579(1):191-8.
2004: Paul J Coffer; Boudewijn M T Burgering
Forkhead-box transcription factors and their role in the immune system.
Nature reviews. Immunology 2004;4(11):889-99.
2004: Silvia Fernández de Mattos; Abdelkader Essafi; Inês Soeiro; Alexandra M Pietersen; Kim U Birkenkamp; Corinne S Edwards; Anthony Martino; Brad H Nelson; Julia M Francis; Marius C Jones; Jan J Brosens; Paul J Coffer; Eric W-F Lam
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.
Molecular and cellular biology 2004;24(22):10058-71.
2004: Miranda Buitenhuis; Paul J Coffer; Leo Koenderman
Signal transducer and activator of transcription 5 (STAT5).
The international journal of biochemistry & cell biology 2004;36(11):2120-4.
2004: P H J Remans; Sonja I Gringhuis; Jacob M van Laar; Marjolein E Sanders; Ellen A M Papendrecht-van der Voort; Fried J T Zwartkruis; E W Nivine Levarht; Marcela Rosas; Paul J Coffer; Ferdinand C Breedveld; Johannes L Bos; Paul P Tak; Cornelis L Verweij; Kris A Reedquist
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):920-31.
2004: Marcela Rosas; Iain Uings; Corneli W van Aalst; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748.
Cytokine 2004;26(6):247-54.
2004: Caroline A Lindemans; Paul J Coffer
Regulation of granulocyte apoptosis by phosphatidylinositol 3-kinase.
Biochemical Society transactions 2004;32(Pt3):480-4.
2004: Petra de Graaf; Wilbert T Zwart; Remco A J van Dijken; Magdalena Deneka; Thomas K F Schulz; Niels Geijsen; Paul J Coffer; Bart M Gadella; Arie J Verkleij; Peter van Der Sluijs; Paul M P van Bergen en Henegouwen
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.
Molecular biology of the cell 2004;15(4):2038-47.
2004: Walbert J Bakker; Montserrat Blázquez-Domingo; Andrea Kolbus; Janey Besooyen; Peter Steinlein; Hartmut Beug; Paul J Coffer; Bob Löwenberg; Marieke von Lindern; Thamar B van Dijk
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
The Journal of cell biology 2004;164(2):175-84.
2003: Andrew Sunters; Silvia Fernández de Mattos; Marie Stahl; Jan J Brosens; Georgia Zoumpoulidou; Catherine A Saunders; Paul J Coffer; René H Medema; R Charles Coombes; Eric W-F Lam
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
The Journal of biological chemistry 2003;278(50):49795-805.
2003: Paul J Coffer
OutFOXing the grim reaper: novel mechanisms regulating longevity by forkhead transcription factors.
Science's STKE : signal transduction knowledge environment 2003;2003(201):PE39.
2003: Paul J Coffer
Transcriptional regulation of lymphocyte quiescence: as cunning as a FOX.
Trends in immunology 2003;24(9):470-1; author reply 471.
2003: Jonathan Gilley; Paul J Coffer; Jonathan Ham
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
The Journal of cell biology 2003;162(4):613-22.
2003: Kim U Birkenkamp; Paul J Coffer
FOXO transcription factors as regulators of immune homeostasis: molecules to die for?
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1623-9.
2003: Andrea M Woltman; Sandra W van der Kooij; Paul J Coffer; Rienk Offringa; Mohamed R Daha; Cees van Kooten
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression.
Blood 2003;101(4):1439-45.
2003: Kim U Birkenkamp; Paul J Coffer
Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors.
Biochemical Society transactions 2003;31(Pt 1):292-7.
2003: Miranda Buitenhuis; Belinda Baltus; Jan-Willem J Lammers; Paul J Coffer; Leo Koenderman
Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells.
Blood 2003;101(1):134-42.
2002: Geert J P L Kops; Tobias B Dansen; Paulien E Polderman; Ingrid Saarloos; Karel W A Wirtz; Paul J Coffer; Ting-T Huang; Johannes L Bos; René H Medema; Boudewijn M T Burgering
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature 2002;419(6904):316-21.
2002: Sandra Verploegen; Caroline M van Leeuwen; Hanneke W M van Deutekom; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase.
European journal of biochemistry / FEBS 2002;269(18):4625-34.
2002: Marie Stahl; Pascale F Dijkers; Geert J P L Kops; Susanne M A Lens; Paul J Coffer; Boudewijn M T Burgering; René H Medema
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5024-31.
2002: Geert J P L Kops; René H Medema; Janet Glassford; Marieke A G Essers; Pascale F Dijkers; Paul J Coffer; Eric W-F Lam; Boudewijn M T Burgering
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.
Molecular and cellular biology 2002;22(7):2025-36.
2002: Pascale F Dijkers; Kim U Birkenkamp; Eric W-F Lam; N Shaun B Thomas; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity.
The Journal of cell biology 2002;156(3):531-42.
2002: Evert H J Nijhuis; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning.
Journal of leukocyte biology 2002;71(1):115-24.
2001: Niels Geijsen; Iain Uings; CM Pals; J Armstrong; Murray McKinnon; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.
Science (New York, N.Y.) 2001;293(5532):1136-8.
2001: Madelon Bracke; Jan-Willem J Lammers; Paul J Coffer; Leo Koenderman
Cytokine-induced inside-out activation of FcalphaR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor.
Blood 2001;97(11):3478-83.
2001: Niels Geijsen; Leo Koenderman; Paul J Coffer
Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.
Cytokine & growth factor reviews 2001;12(1):19-25.
2001: Leo Koenderman; J van der Linden; Laurien H Ulfman; Paul J Coffer
Eosinophils : collection, separation, and activation.
Methods in molecular medicine 2001;56():217-26.
2000: Pascale F Dijkers; René H Medema; CM Pals; Lolita Banerji; N Shaun B Thomas; Eric W-F Lam; Boudewijn M T Burgering; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Molecular and cellular biology 2000;20(24):9138-48.
2000: Madelon Bracke; Ed A van de Graaf; Jan-Willem J Lammers; Paul J Coffer; Leo Koenderman
In vivo priming of FcalphaR functioning on eosinophils of allergic asthmatics.
Journal of leukocyte biology 2000;68(5):655-61.
2000: Sandra Verploegen; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase.
Blood 2000;96(9):3215-23.
2000: Pascale F Dijkers; René H Medema; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.
Current biology : CB 2000;10(19):1201-4.
2000: Henri H Versteeg; Evert H J Nijhuis; Gijs R van den Brink; M Evertzen; Gwenda Pynaert; Sander J H van Deventer; Paul J Coffer; Maikel Peppelenbosch
A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein.
The Biochemical journal 2000;350 Pt 3():717-22.
2000: Paul J Coffer; Leo Koenderman; RP de Groot
The role of STATs in myeloid differentiation and leukemia.
Oncogene 2000;19(21):2511-22.
2000: Niels Geijsen; Pascale F Dijkers; J J Lammers; Leo Koenderman; Paul J Coffer
Cytokine-mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members.
FEBS letters 2000;471(1):83-8.
2000: CM Pals; Sandra Verploegen; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Identification of cytokine-regulated genes in human leukocytes in vivo.
The Journal of allergy and clinical immunology 2000;105(4):760-8.
2000: Madelon Bracke; Evert H J Nijhuis; Jan-Willem J Lammers; Paul J Coffer; Leo Koenderman
A critical role for PI 3-kinase in cytokine-induced Fcalpha-receptor activation.
Blood 2000;95(6):2037-43.
1999: Niels Geijsen; M Spaargaren; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.
Oncogene 1999;18(36):5126-30.
1999: Niels Geijsen; S van Delft; Jan A M Raaijmakers; Jan-Willem J Lammers; John G Collard; Leo Koenderman; Paul J Coffer
Regulation of p21rac activation in human neutrophils.
Blood 1999;94(3):1121-30.
1999: L M'Rabet; Paul J Coffer; RM Wolthuis; Fried J T Zwartkruis; Leo Koenderman; Johannes L Bos
Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.
The Journal of biological chemistry 1999;274(31):21847-52.
1999: Pascale F Dijkers; Thamar B van Dijk; RP de Groot; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.
Oncogene 1999;18(22):3334-42.
1998: Madelon Bracke; Paul J Coffer; Jan-Willem J Lammers; Leo Koenderman
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6768-74.
1998: RP de Groot; Paul J Coffer; Leo Koenderman
Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family.
Cellular signalling 1998;10(9):619-28.
1998: Paul J Coffer; J Jin; J R Woodgett
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
The Biochemical journal 1998;335 ( Pt 1)():1-13.
1998: L M'Rabet; Paul J Coffer; Fried J T Zwartkruis; B Franke; A W Segal; Leo Koenderman; Johannes L Bos
Activation of the small GTPase rap1 in human neutrophils.
Blood 1998;92(6):2133-40.
1998: Paul J Coffer; René C Schweizer; G R Dubois; T Maikoe; Jan-Willem J Lammers; Leo Koenderman
Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5.
Blood 1998;91(7):2547-57.
1998: Sonja I Gringhuis; Lou F M H De Leij; Paul J Coffer; Edo Vellenga
Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes.
Molecular and cellular biology 1998;18(3):1725-35.
1998: Keisuke Ueki; Ritsuko Yamamoto-Honda; Yasushi Kaburagi; Toshimasa Yamauchi; Kazuyuki Tobe; Boudewijn M T Burgering; Paul J Coffer; Issei Komuro; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis.
The Journal of biological chemistry 1998;273(9):5315-22.
1998: Paul J Coffer; Niels Geijsen; L M'Rabet; René C Schweizer; T Maikoe; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
The Biochemical journal 1998;329 ( Pt 1)():121-30.
1997: Paul J Coffer; AA van Puijenbroek; Boudewijn M T Burgering; M Klop-de Jonge; Leo Koenderman; Johannes L Bos; Wiebe Kruijer
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction.
Oncogene 1997;15(21):2529-39.
1997: Paul J Coffer; Leo Koenderman
Granulocyte signal transduction and priming: cause without effect?
Immunology letters 1997;57(1-3):27-31.
1997: RP de Groot; Thamar B van Dijk; E Caldenhoven; Paul J Coffer; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman
Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases.
The Journal of biological chemistry 1997;272(4):2319-25.
1996: Leo Koenderman; T van der Bruggen; René C Schweizer; R A Warringa; Paul J Coffer; E Caldenhoven; Jan-Willem J Lammers; Jan A M Raaijmakers
Eosinophil priming by cytokines: from cellular signal to in vivo modulation.
The European respiratory journal. Supplement 1996;22():119s-125s.
1996: R Magun; Boudewijn M T Burgering; Paul J Coffer; D Pardasani; Y Lin; J Chabot; Alexander Sorisky
Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation.
Endocrinology 1996;137(8):3590-3.
1995: Boudewijn M T Burgering; Paul J Coffer
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.
Nature 1995;376(6541):599-602.
1995: Paul J Coffer; Boudewijn M T Burgering; Maikel Peppelenbosch; Johannes L Bos; Wiebe Kruijer
UV activation of receptor tyrosine kinase activity.
Oncogene 1995;11(3):561-9.
1995: Paul J Coffer; Wiebe Kruijer
EGF receptor deletions define a region specifically mediating STAT transcription factor activation.
Biochemical and biophysical research communications 1995;210(1):74-81.
1995: T van der Bruggen; E Caldenhoven; D Kanters; Paul J Coffer; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman
Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.
Blood 1995;85(6):1442-8.
1995: Paul J Coffer; C Lutticken; AA van Puijenbroek; M Klop-de Jonge; Friedemann Horn; Wiebe Kruijer
Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction.
Oncogene 1995;10(5):985-94.
1995: C Lütticken; Paul J Coffer; J Yuan; C Schwartz; E Caldenhoven; Christian Schindler; Wiebe Kruijer; Peter C Heinrich; Friedemann Horn
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
FEBS letters 1995;360(2):137-43.
1994: E Caldenhoven; Paul J Coffer; J Yuan; A Van de Stolpe; Friedemann Horn; Wiebe Kruijer; Paul T van der Saag
Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element.
The Journal of biological chemistry 1994;269(33):21146-54.
1994: Paul J Coffer; M de Jonge; A Mettouchi; B Binetruy; J Ghysdael; Wiebe Kruijer
junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2.
Oncogene 1994;9(3):911-21.
1993: S van Delft; Paul J Coffer; Wiebe Kruijer; Roeland Van Wijk
c-fos induction by stress can be mediated by the SRE.
Biochemical and biophysical research communications 1993;197(2):542-8.