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Robert Coffin

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Mirko Kummer; Nadine M Turza; Petra Muhl-Zurbes; Matthias Lechmann; Chris Boutell; Robert S Coffin; Roger D Everett; Alexander Steinkasserer; Alexander T Prechtel
Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome.
Z Q Han; M Assenberg; B L Liu; Y B Wang; G Simpson; S Thomas; Robert S Coffin
Development of a second-generation oncolytic Herpes simplex virus expressing TNFalpha for cancer therapy.
Pascal Ghislain Leclere; Emma Norman; Filitsa Groutsi; Robert S Coffin; Ulrike Mayer; John Pizzey; David A Tonge
Impaired axonal regeneration by isolectin B4-binding dorsal root ganglion neurons in vitro.

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All Publications

2007: Mirko Kummer; Nadine M Turza; Petra Muhl-Zurbes; Matthias Lechmann; Chris Boutell; Robert S Coffin; Roger D Everett; Alexander Steinkasserer; Alexander T Prechtel
Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome.
Journal of virology 2007;81(12):6326-38.
2007: Z Q Han; M Assenberg; B L Liu; Y B Wang; G Simpson; S Thomas; Robert S Coffin
Development of a second-generation oncolytic Herpes simplex virus expressing TNFalpha for cancer therapy.
The journal of gene medicine 2007;9(2):99-106.
2007: Pascal Ghislain Leclere; Emma Norman; Filitsa Groutsi; Robert S Coffin; Ulrike Mayer; John Pizzey; David A Tonge
Impaired axonal regeneration by isolectin B4-binding dorsal root ganglion neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(5):1190-9.
2006: Jennifer C Hu; Matthew J Booth; Gopichand Tripuraneni; Derek Davies; Syed A A Zaidi; Manuela Tamburo de Bella; Martin J Slade; Stephen B Marley; Myrtle Y A Gordon; Robert S Coffin; R Charles Coombes; Tahereh Kamalati
A novel HSV-1 virus, JS1/34.5-/47-, purges contaminating breast cancer cells from bone marrow.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6853-62.
2006: Jennifer C C Hu; Robert S Coffin; Ceri J Davis; Nicola J Graham; Natasha Groves; Peter J Guest; Kevin J Harrington; Nicholas James; Colin A Love; Iain McNeish; Louise C Medley; Agnieszka Michael; christopher nutting; Hardev Pandha; Claire A Shorrock; Julie Simpson; Jan Steiner; Neil M Steven; Dennis Wright; R Charles Coombes
A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6737-47.
2006: Nigel Pheasey; Justin John; Colin Love; Robert S Coffin; John M Ward; Rihab Boushaba; Mike Hoare; M Susana Levy
A capillary cytometer method to quantitate viable virus particles based on early detection of viral antigens and cellular events within single cells.
Journal of virological methods 2006;137(2):213-8.
2005: Alexander T Prechtel; Nadine M Turza; Dieter J Kobelt; Jutta Eisemann; Robert S Coffin; Yvonne McGrath; Christine Hacker; Xinsheng Ju; Martin Zenke; Alexander Steinkasserer
Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration.
The Journal of general virology 2005;86(Pt 6):1645-57.
2004: M Robinson; M C Parsons Perez; L Tébar; J Palmer; A Patel; D Marks; Anne Sheasby; Carmen De Felipe; Robert S Coffin; FJ Livesey; Stephen P Hunt
FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth.
Molecular and cellular neurosciences 2004;27(2):202-14.
2004: Gabriele Pollara; Meleri Jones; Matthew E Handley; Mansi Rajpopat; Antonia Kwan; Robert S Coffin; Graham Foster; Benjamin M Chain; David R Katz
Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):4108-19.
2004: M C P Perez; Stephen P Hunt; Robert S Coffin; JA Palmer
Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo.
Gene therapy 2004;11(13):1023-32.
2004: M J Booth; Ajay R Mistry; X Li; Adrian J Thrasher; Robert S Coffin
Transfection-free and scalable recombinant AAV vector production using HSV/AAV hybrids.
Gene therapy 2004;11(10):829-37.
2004: David Hunt; Kismet Hossain-Ibrahim; M R J Mason; Robert S Coffin; A Robert Lieberman; Julia Winterbottom; Patrick N Anderson
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter.
BMC neuroscience 2004;5():9.
2003: David Hunt; Robert S Coffin; Rab Prinjha; Gregor Campbell; Patrick N Anderson
Nogo-A expression in the intact and injured nervous system.
Molecular and cellular neurosciences 2003;24(4):1083-102.
2003: Pantea Lotfian; M Susana Levy; Robert S Coffin; John Ward; Parviz Ayazi Shamlou
Shear-induced release of disabled herpes simplex virus from baby-hamster kidney cells.
Biotechnology and applied biochemistry 2003;38(Pt 3):271-81.
2003: Stephan A Kalwy; Mohammed T Akbar; Robert S Coffin; Jackie de Belleroche; David S Latchman
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.
Brain research. Molecular brain research 2003;111(1-2):91-103.
2003: Laila Samady; Emanuela Costigliola; Luci P MacCormac; Yvonne McGrath; Steve Cleverley; Caroline E Lilley; Jill Smith; David S Latchman; Benjamin M Chain; Robert S Coffin
Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.
Journal of virology 2003;77(6):3768-76.
2003: B L Liu; M Robinson; Z-Q Han; RH Branston; C English; P Reay; Yvonne McGrath; SK Thomas; M Thornton; P Bullock; C A Love; Robert S Coffin
ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties.
Gene therapy 2003;10(4):292-303.
2003: Gabriele Pollara; Katharina Speidel; Laila Samady; Mansi Rajpopat; Yvonne McGrath; Jonathan A Ledermann; Robert S Coffin; David R Katz; Benjamin M Chain
Herpes simplex virus infection of dendritic cells: balance among activation, inhibition, and immunity.
The Journal of infectious diseases 2003;187(2):165-78.
2003: Pantea Lotfian; M Susana Levy; Robert S Coffin; Tom Fearn; Parviz Ayazi-Shamlou
Impact of process conditions on the centrifugal recovery of a disabled herpes simplex virus.
Biotechnology progress 2003;19(1):209-15.
2003: Caroline E Lilley; Robert S Coffin
Construction of multiply disabled herpes simplex viral vectors for gene delivery to the nervous system.
Methods in molecular medicine 2003;76():33-49.
2002: Yogesh Patel; Yolanda Collaco Moraes; David S Latchman; Robert S Coffin; Jackie de Belleroche
Neuroprotective effects of copper/zinc-dependent superoxide dismutase against a wide variety of death-inducing stimuli and proapoptotic effect of familial amyotrophic lateral sclerosis mutations.
Brain research. Molecular brain research 2002;109(1-2):189-97.
2002: David Hunt; M R J Mason; Gregor Campbell; Robert S Coffin; Patrick N Anderson
Nogo receptor mRNA expression in intact and regenerating CNS neurons.
Molecular and cellular neurosciences 2002;20(4):537-52.
2002: SK Thomas; Caroline E Lilley; David S Latchman; Robert S Coffin
A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome.
Journal of virology 2002;76(8):4056-67.
2002: David Hunt; Robert S Coffin; Patrick N Anderson
The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review.
Journal of neurocytology 2002;31(2):93-120.
2001: Caroline E Lilley; RH Branston; Robert S Coffin
Herpes simplex virus vectors for the nervous system.
Current gene therapy 2001;1(4):339-58.
2001: MJ Wright; LM Wightman; Caroline E Lilley; Mahesh De Alwis; Stephen Hart; A Miller; Robert S Coffin; Adrian J Thrasher; David S Latchman; Michael S Marber
In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors.
Basic research in cardiology 2001;96(3):227-36.
2001: Caroline E Lilley; F Groutsi; Z Han; JA Palmer; Patrick N Anderson; David S Latchman; Robert S Coffin
Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo.
Journal of virology 2001;75(9):4343-56.
2001: Adam Lacy-Hulbert; R Thomas; X P Li; Caroline E Lilley; Robert S Coffin; Jürgen Roes
Interruption of coding sequences by heterologous introns can enhance the functional expression of recombinant genes.
Gene therapy 2001;8(8):649-53.
2000: JA Palmer; RH Branston; Caroline E Lilley; M J Robinson; F Groutsi; Jill Smith; David S Latchman; Robert S Coffin
Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system.
Journal of virology 2000;74(12):5604-18.
2000: David S Latchman; Robert S Coffin
Viral vectors in the treatment of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(1):9-17.
1999: SK Thomas; Caroline E Lilley; David S Latchman; Robert S Coffin
Equine herpesvirus 1 gene 12 can substitute for vmw65 in the growth of herpes simplex virus (HSV) type 1, allowing the generation of optimized cell lines for the propagation of HSV vectors with multiple immediate-early gene defects.
Journal of virology 1999;73(9):7399-409.
1999: SK Thomas; G Gough; David S Latchman; Robert S Coffin
Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency.
Journal of virology 1999;73(8):6618-25.
1999: J Brownlees; G Gough; S Thomas; P Watts; J Cohen; Robert S Coffin; David S Latchman
Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b.
The international journal of biochemistry & cell biology 1999;31(3-4):451-61.
1999: MJ Wagstaff; Y Collaço-Moraes; Jill Smith; Jackie de Belleroche; Robert S Coffin; David S Latchman
Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector.
The Journal of biological chemistry 1999;274(8):5061-9.
1999: Bhawanjit K Brar; Anastasis Stephanou; MJ Wagstaff; Robert S Coffin; Michael S Marber; G Engelmann; David S Latchman
Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress.
Journal of molecular and cellular cardiology 1999;31(1):135-46.
1998: Robert S Coffin; SK Thomas; D P Thomas; David S Latchman
The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: possible function of LAT ORFs.
The Journal of general virology 1998;79 ( Pt 12)():3019-26.
1998: MJ Wagstaff; Caroline E Lilley; Jill Smith; M J Robinson; Robert S Coffin; David S Latchman
Gene transfer using a disabled herpes virus vector containing the EMCV IRES allows multiple gene expression in vitro and in vivo.
Gene therapy 1998;5(11):1566-70.
1998: MJ Wagstaff; Jill Smith; Y Collaco-Moraes; Jackie de Belleroche; R Voellmy; Robert S Coffin; David S Latchman
Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.
The European journal of neuroscience 1998;10(11):3343-50.
1998: M K Howard; T Kershaw; Barry J Gibb; N Storey; A R MacLean; Bai-Yun Zeng; Banu C Tel; Peter Jenner; S M Brown; Clifford J Woolf; Patrick N Anderson; Robert S Coffin; David S Latchman
High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5.
Gene therapy 1998;5(8):1137-47.
1998: MD Smith; E A Ensor; Robert S Coffin; LM Boxer; David S Latchman
Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor.
The Journal of biological chemistry 1998;273(27):16715-22.
1998: Y Patel; G Gough; Robert S Coffin; S Thomas; J I Cohen; David S Latchman
Cell type specific repression of the varicella zoster virus immediate early gene 62 promoter by the cellular Oct-2 transcription factor.
Biochimica et biophysica acta 1998;1397(3):268-74.
1998: Robert S Coffin; SK Thomas; N Shaun B Thomas; Caroline E Lilley; Arnold Pizzey; C H Griffiths; Barry J Gibb; MJ Wagstaff; S J Inges; Michael Binks; Benjamin M Chain; Adrian J Thrasher; Karine Rutault; David S Latchman
Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry.
Gene therapy 1998;5(5):718-22.
1998: S Thomas; Robert S Coffin; P Watts; G Gough; David S Latchman
The TAATGARAT motif in the herpes simplex virus immediate-early gene promoters can confer both positive and negative responses to cellular octamer-binding proteins when it is located within the viral genome.
Journal of virology 1998;72(4):3495-500.
1997: M K Howard; Robert S Coffin; A R Maclean; S M Brown; D Bailey; Patrick N Anderson; G Burnstock; David S Latchman
Gene delivery to rat enteric neurons using herpes simplex virus-based vectors.
Journal of molecular neuroscience : MN 1997;9(2):65-74.
1996: MJ Wagstaff; Y Collaço-Moraes; B S Aspey; Robert S Coffin; MJ Harrison; David S Latchman; Jackie de Belleroche
Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs.
Brain research. Molecular brain research 1996;42(2):236-44.
1996: Robert S Coffin; A R MacLean; David S Latchman; S M Brown
Gene delivery to the central and peripheral nervous systems of mice using HSV1 ICP34.5 deletion mutant vectors.
Gene therapy 1996;3(10):886-91.
1996: D V Cumming; R J Heads; Robert S Coffin; Derek M Yellon; David S Latchman
Pharmacological preconditioning of primary rat cardiac myocytes by FK506.
Basic research in cardiology 1996;91(5):367-73.
1996: Robert S Coffin; M K Howard; D V Cumming; C M Dollery; J McEwan; Derek M Yellon; Michael S Marber; A R MacLean; S M Brown; David S Latchman
Gene delivery to the heart in vivo and to cardiac myocytes and vascular smooth muscle cells in vitro using herpes virus vectors.
Gene therapy 1996;3(7):560-6.
1995: V Amin; D V Cumming; Robert S Coffin; David S Latchman
The degree of protection provided to neuronal cells by a pre-conditioning stress correlates with the amount of heat shock protein 70 it induces and not with the similarity of the subsequent stress.
Neuroscience letters 1995;200(2):85-8.
1995: Robert S Coffin; M K Howard; David S Latchman
Altered dinucleotide content within the latently transcribed regions of the DNA of alpha herpes viruses--implications for latent RNA expression and DNA structure.
Virology 1995;209(2):358-65.